CCND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)5.41798523
2hippo signaling (GO:0035329)4.48297583
3mesodermal cell differentiation (GO:0048333)4.25037883
4basement membrane organization (GO:0071711)4.15883368
5protein retention in ER lumen (GO:0006621)4.07908232
6hemidesmosome assembly (GO:0031581)4.07032224
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.05767126
8paraxial mesoderm development (GO:0048339)4.04588579
9chondrocyte proliferation (GO:0035988)3.97185936
10endodermal cell differentiation (GO:0035987)3.86332532
11renal filtration (GO:0097205)3.80617319
12regulation of hippo signaling (GO:0035330)3.78669881
13negative regulation of smooth muscle cell migration (GO:0014912)3.69866387
14protein heterotrimerization (GO:0070208)3.69862746
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.66963917
16cellular response to vitamin D (GO:0071305)3.63157247
17lens fiber cell development (GO:0070307)3.62667163
18type B pancreatic cell proliferation (GO:0044342)3.56695425
19focal adhesion assembly (GO:0048041)3.47260124
20cell-substrate adherens junction assembly (GO:0007045)3.47260124
21heterochromatin organization (GO:0070828)3.42512090
22polarized epithelial cell differentiation (GO:0030859)3.41094262
23desmosome organization (GO:0002934)3.40364452
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38705019
25positive regulation of endothelial cell apoptotic process (GO:2000353)3.29979455
26positive regulation of blood vessel endothelial cell migration (GO:0043536)3.25917256
27muscle cell migration (GO:0014812)3.24282589
28cell migration involved in sprouting angiogenesis (GO:0002042)3.23540468
29collagen fibril organization (GO:0030199)3.23461620
30regulation of SMAD protein import into nucleus (GO:0060390)3.20749812
31kidney mesenchyme development (GO:0072074)3.20681403
32cellular response to vitamin (GO:0071295)3.20313070
33apoptotic cell clearance (GO:0043277)3.19317441
34glomerular basement membrane development (GO:0032836)3.18328294
35negative regulation of chondrocyte differentiation (GO:0032331)3.17215212
36regulation of cell fate specification (GO:0042659)3.16571926
37hypotonic response (GO:0006971)3.15571493
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.13005658
39skin morphogenesis (GO:0043589)3.09623109
40epithelial cell-cell adhesion (GO:0090136)3.08607860
41negative regulation of fatty acid transport (GO:2000192)3.06988443
42neuron projection extension involved in neuron projection guidance (GO:1902284)3.06850535
43axon extension involved in axon guidance (GO:0048846)3.06850535
44endothelial cell morphogenesis (GO:0001886)3.06850039
45vascular endothelial growth factor signaling pathway (GO:0038084)3.06147094
46lung-associated mesenchyme development (GO:0060484)3.05656761
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03172199
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.02689596
49barbed-end actin filament capping (GO:0051016)3.01814104
50cell-substrate junction assembly (GO:0007044)3.01432606
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.01109275
52DNA unwinding involved in DNA replication (GO:0006268)2.99746499
53renal system development (GO:0072001)2.97545203
54embryonic camera-type eye development (GO:0031076)2.97223314
55bone trabecula formation (GO:0060346)2.95319241
56substrate adhesion-dependent cell spreading (GO:0034446)2.95172096
57regulation of glucose import in response to insulin stimulus (GO:2001273)2.91366351
58wound healing, spreading of epidermal cells (GO:0035313)2.90550773
59protein maturation by protein folding (GO:0022417)2.90446908
60Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90445110
61retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89722856
62positive regulation of epithelial to mesenchymal transition (GO:0010718)2.89231975
63mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.88951154
64branching involved in salivary gland morphogenesis (GO:0060445)2.88700596
65collecting duct development (GO:0072044)2.87577714
66positive regulation of SMAD protein import into nucleus (GO:0060391)2.85387166
67COPI coating of Golgi vesicle (GO:0048205)2.82449174
68Golgi transport vesicle coating (GO:0048200)2.82449174
69stress fiber assembly (GO:0043149)2.82243322
70regulation of glomerular filtration (GO:0003093)2.80583128
71plasma membrane repair (GO:0001778)2.80251654
72embryonic foregut morphogenesis (GO:0048617)2.80145536
73regulation of establishment of planar polarity (GO:0090175)2.79753028
74glial cell proliferation (GO:0014009)2.79504680
75adherens junction assembly (GO:0034333)2.78552532
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.78180733
77substrate-dependent cell migration (GO:0006929)2.77820721
78regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.77211899
79protein hydroxylation (GO:0018126)2.76584101
80cell migration involved in heart development (GO:0060973)2.75186413
81NLS-bearing protein import into nucleus (GO:0006607)2.73661613
82heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.73001802
83sequestering of extracellular ligand from receptor (GO:0035581)2.72891098
84G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71312216
85semaphorin-plexin signaling pathway (GO:0071526)2.71186629
86blood vessel endothelial cell migration (GO:0043534)2.69171164
87vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67618327
88chromatin assembly (GO:0031497)2.67285020
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67017838
90respiratory tube development (GO:0030323)2.63620919
91extracellular matrix disassembly (GO:0022617)2.62956219
92peptidyl-proline hydroxylation (GO:0019511)2.62929696
93dorsal/ventral axis specification (GO:0009950)2.62782966
94positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.62439465
95extracellular matrix assembly (GO:0085029)2.61475645
96regulation of cellular senescence (GO:2000772)2.61392402
97vesicle coating (GO:0006901)2.60740938
98activation of Rac GTPase activity (GO:0032863)2.60102758
99protein localization to cell surface (GO:0034394)2.60008419
100COPII vesicle coating (GO:0048208)2.59756658
101apoptotic process involved in morphogenesis (GO:0060561)2.59147321
102regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58858940
103endocardial cushion development (GO:0003197)2.58199812
104cellular response to interferon-alpha (GO:0035457)2.57906856
105negative regulation of stem cell proliferation (GO:2000647)2.57515044
106regulation of cell aging (GO:0090342)2.56752319
107regulation of heart morphogenesis (GO:2000826)2.55901570
108cochlea morphogenesis (GO:0090103)2.55720491
109regulation of mitotic spindle organization (GO:0060236)2.55171555
110wound healing, spreading of cells (GO:0044319)2.55168210
111establishment of apical/basal cell polarity (GO:0035089)2.55110064
112multicellular organismal macromolecule metabolic process (GO:0044259)2.53983563
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.53699940
114notochord development (GO:0030903)2.53509003
115collagen metabolic process (GO:0032963)2.53481404
116negative regulation of cartilage development (GO:0061037)2.52935065
117adhesion of symbiont to host cell (GO:0044650)2.52257727
118virion attachment to host cell (GO:0019062)2.52257727
119negative regulation of catenin import into nucleus (GO:0035414)2.51654169
120axis elongation (GO:0003401)2.51483774
121glomerular filtration (GO:0003094)2.51361427
122anatomical structure regression (GO:0060033)2.50422566
123positive regulation of osteoblast proliferation (GO:0033690)2.49658676
124regulation of early endosome to late endosome transport (GO:2000641)2.49380169
125endothelial cell chemotaxis (GO:0035767)2.49138225
126labyrinthine layer blood vessel development (GO:0060716)2.48474920
127outer ear morphogenesis (GO:0042473)2.48431028
128positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.48403656
129protein localization to endosome (GO:0036010)2.47901805
130branching involved in mammary gland duct morphogenesis (GO:0060444)2.47846585
131pattern specification involved in kidney development (GO:0061004)2.47767602
132mesenchymal-epithelial cell signaling (GO:0060638)2.47587839
133membrane protein ectodomain proteolysis (GO:0006509)2.47213860
134negative regulation of osteoblast proliferation (GO:0033689)2.46498244
135membrane raft organization (GO:0031579)2.46306429
136regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.46015353
137actin filament depolymerization (GO:0030042)2.45204299
138positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.44806831
139negative regulation of anoikis (GO:2000811)2.44662863
140regulation of plasminogen activation (GO:0010755)2.44065033
141endocytic recycling (GO:0032456)2.43769665
142collagen catabolic process (GO:0030574)2.43157882
143mitotic cytokinesis (GO:0000281)2.43113875
144negative regulation of axon extension involved in axon guidance (GO:0048843)2.42942489
145positive regulation of endothelial cell migration (GO:0010595)2.42762754
146lung vasculature development (GO:0060426)2.42126552
147organ formation (GO:0048645)2.41704768
148positive regulation of protein localization to plasma membrane (GO:1903078)2.40524947
149germ cell migration (GO:0008354)2.40341540
150multicellular organismal metabolic process (GO:0044236)2.36719099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.91074772
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.20645244
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.69241378
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.69010985
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.61934426
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44857442
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.33586343
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18086568
9CLOCK_20551151_ChIP-Seq_293T_Human3.01232914
10* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.69768274
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67958339
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.64237867
13E2F7_22180533_ChIP-Seq_HELA_Human2.49655612
14AR_21909140_ChIP-Seq_LNCAP_Human2.45025717
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29442924
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.21426510
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.13266821
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02976861
19SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.94584094
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94276272
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94276272
22* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90337023
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89646741
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.87878005
25* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83268637
26ZNF263_19887448_ChIP-Seq_K562_Human1.83008223
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.79631518
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76770679
29* BRD4_25478319_ChIP-Seq_HGPS_Human1.76369167
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71616999
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71264316
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69842064
33* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.63187763
34* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63158089
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62975629
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62838920
37ATF3_27146783_Chip-Seq_COLON_Human1.61845528
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.58352440
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55364307
40* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52517404
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.52365421
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52215643
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49414523
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.49238998
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47461319
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47056974
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47036188
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45805270
49CJUN_26792858_Chip-Seq_BT549_Human1.41925385
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40790153
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.40004724
52* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38875131
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37181355
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.36509161
55LXR_22292898_ChIP-Seq_THP-1_Human1.35888024
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35529204
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35395793
58* RACK7_27058665_Chip-Seq_MCF-7_Human1.32767392
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31083648
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30876250
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30410645
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30303753
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26491481
64* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26197305
65* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25462349
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24588040
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23707379
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22314824
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21731205
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20555936
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19053315
72SOX2_20726797_ChIP-Seq_SW620_Human1.18859461
73TP53_22127205_ChIP-Seq_IMR90_Human1.18709481
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17780423
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.17560975
76* KDM2B_26808549_Chip-Seq_K562_Human1.17288277
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.16913148
78CHD1_26751641_Chip-Seq_LNCaP_Human1.16905872
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15995787
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15082096
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14561437
82* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14204431
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12005230
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11511593
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.10476866
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.10359786
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09908800
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.09313115
89GATA6_25053715_ChIP-Seq_YYC3_Human1.08147341
90MYC_22102868_ChIP-Seq_BL_Human1.07997325
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07750834
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07640739
93* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07546689
94KDM2B_26808549_Chip-Seq_DND41_Human1.05738886
95* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05511410
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05193237
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04858065
98* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04061379
99P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02827380
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02442888
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.01691292
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00843186
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00795918
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99566050
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98764487
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98224804
107NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97766889
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97664430
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.97552219
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97442453
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95994408
112* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95673704
113* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95404757
114MYC_18555785_ChIP-Seq_MESCs_Mouse0.95322225
115* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95309308
116* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95116563
117* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94473864
118TP53_16413492_ChIP-PET_HCT116_Human0.93573325
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.93353728
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91409631
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91045228
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.90796661
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.90796661
124* TCF7_22412390_ChIP-Seq_EML_Mouse0.90359943
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.89449275
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88446997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.26704694
2MP0004272_abnormal_basement_membrane3.55848707
3MP0008438_abnormal_cutaneous_collagen3.54524438
4MP0000537_abnormal_urethra_morphology3.09825612
5MP0005623_abnormal_meninges_morphology2.95903892
6MP0010352_gastrointestinal_tract_polyps2.95056816
7MP0009053_abnormal_anal_canal2.71650988
8MP0005275_abnormal_skin_tensile2.50077434
9MP0010234_abnormal_vibrissa_follicle2.38240583
10MP0009780_abnormal_chondrocyte_physiolo2.24815477
11MP0003566_abnormal_cell_adhesion2.23470673
12MP0003950_abnormal_plasma_membrane2.23413921
13MP0005076_abnormal_cell_differentiation2.10152640
14MP0003300_gastrointestinal_ulcer2.04445720
15MP0010030_abnormal_orbit_morphology2.02715336
16MP0003283_abnormal_digestive_organ1.93310743
17MP0000733_abnormal_muscle_development1.88376698
18MP0005503_abnormal_tendon_morphology1.86283273
19MP0001958_emphysema1.84057747
20MP0003091_abnormal_cell_migration1.81251364
21MP0005257_abnormal_intraocular_pressure1.79406270
22MP0000751_myopathy1.77086630
23MP0003279_aneurysm1.73640947
24MP0005248_abnormal_Harderian_gland1.68602081
25MP0001542_abnormal_bone_strength1.67847172
26MP0006054_spinal_hemorrhage1.65133481
27MP0001849_ear_inflammation1.63301453
28MP0009384_cardiac_valve_regurgitation1.61757077
29MP0003942_abnormal_urinary_system1.61377698
30MP0005023_abnormal_wound_healing1.61208859
31MP0002282_abnormal_trachea_morphology1.60233127
32MP0010368_abnormal_lymphatic_system1.59531362
33MP0003115_abnormal_respiratory_system1.58702878
34MP0000534_abnormal_ureter_morphology1.55381241
35MP0002697_abnormal_eye_size1.50248517
36MP0002877_abnormal_melanocyte_morpholog1.47918826
37MP0002896_abnormal_bone_mineralization1.46733347
38MP0000428_abnormal_craniofacial_morphol1.46217664
39MP0001299_abnormal_eye_distance/1.42499297
40MP0005409_darkened_coat_color1.42290884
41MP0003385_abnormal_body_wall1.36068236
42MP0003941_abnormal_skin_development1.32439417
43MP0002060_abnormal_skin_morphology1.31160893
44MP0003937_abnormal_limbs/digits/tail_de1.28675030
45MP0002796_impaired_skin_barrier1.26130037
46MP0005508_abnormal_skeleton_morphology1.25656427
47MP0004197_abnormal_fetal_growth/weight/1.25104586
48MP0010678_abnormal_skin_adnexa1.24442245
49MP0001348_abnormal_lacrimal_gland1.23803827
50MP0001915_intracranial_hemorrhage1.21672364
51MP0009250_abnormal_appendicular_skeleto1.18239250
52MP0003453_abnormal_keratinocyte_physiol1.17418498
53MP0002092_abnormal_eye_morphology1.17107717
54MP0005501_abnormal_skin_physiology1.16542219
55MP0000516_abnormal_urinary_system1.15131584
56MP0005367_renal/urinary_system_phenotyp1.15131584
57MP0003755_abnormal_palate_morphology1.13653252
58MP0009278_abnormal_bone_marrow1.12602048
59MP0000013_abnormal_adipose_tissue1.11600200
60MP0010307_abnormal_tumor_latency1.11274794
61MP0002089_abnormal_postnatal_growth/wei1.08923282
62MP0001293_anophthalmia1.08540548
63* MP0000432_abnormal_head_morphology1.08489760
64MP0008007_abnormal_cellular_replicative1.08458558
65MP0003191_abnormal_cellular_cholesterol1.08290710
66MP0002084_abnormal_developmental_patter1.08254053
67MP0005171_absent_coat_pigmentation1.07569005
68MP0000569_abnormal_digit_pigmentation1.07282353
69MP0003935_abnormal_craniofacial_develop1.06543044
70MP0000767_abnormal_smooth_muscle1.06421806
71MP0002925_abnormal_cardiovascular_devel1.05321083
72MP0000163_abnormal_cartilage_morphology1.04789190
73MP0003045_fibrosis1.04253933
74MP0002932_abnormal_joint_morphology1.03580470
75MP0000003_abnormal_adipose_tissue1.03208438
76MP0005197_abnormal_uvea_morphology1.02186686
77MP0005187_abnormal_penis_morphology1.01608150
78MP0004858_abnormal_nervous_system1.00849818
79MP0002108_abnormal_muscle_morphology1.00532496
80MP0002111_abnormal_tail_morphology0.99433527
81MP0002086_abnormal_extraembryonic_tissu0.98828162
82MP0001879_abnormal_lymphatic_vessel0.97481073
83MP0002085_abnormal_embryonic_tissue0.97331478
84MP0004233_abnormal_muscle_weight0.97112770
85MP0002168_other_aberrant_phenotype0.96508644
86MP0001614_abnormal_blood_vessel0.96047618
87MP0005193_abnormal_anterior_eye0.96018197
88MP0005595_abnormal_vascular_smooth0.95417347
89MP0000759_abnormal_skeletal_muscle0.94932950
90MP0000383_abnormal_hair_follicle0.93975889
91MP0003119_abnormal_digestive_system0.93796635
92MP0000762_abnormal_tongue_morphology0.93796523
93MP0001730_embryonic_growth_arrest0.93185670
94MP0000858_altered_metastatic_potential0.93052867
95MP0000467_abnormal_esophagus_morphology0.92617383
96MP0003984_embryonic_growth_retardation0.91883448
97* MP0001286_abnormal_eye_development0.91545987
98MP0002088_abnormal_embryonic_growth/wei0.91434883
99MP0008932_abnormal_embryonic_tissue0.91315757
100MP0000749_muscle_degeneration0.89091061
101MP0000750_abnormal_muscle_regeneration0.88024489
102MP0002233_abnormal_nose_morphology0.87893513
103MP0004185_abnormal_adipocyte_glucose0.86665473
104MP0005380_embryogenesis_phenotype0.86618652
105MP0001672_abnormal_embryogenesis/_devel0.86618652
106MP0000579_abnormal_nail_morphology0.86556353
107MP0001697_abnormal_embryo_size0.86396336
108MP0002234_abnormal_pharynx_morphology0.85032400
109MP0002177_abnormal_outer_ear0.84974661
110MP0006138_congestive_heart_failure0.84725461
111MP0002113_abnormal_skeleton_development0.83993873
112MP0002115_abnormal_skeleton_extremities0.83651430
113MP0000462_abnormal_digestive_system0.82665753
114MP0000049_abnormal_middle_ear0.82539572
115MP0005451_abnormal_body_composition0.81829543
116MP0002128_abnormal_blood_circulation0.80985647
117MP0000350_abnormal_cell_proliferation0.80967728
118MP0001243_abnormal_dermal_layer0.79323182
119MP0002295_abnormal_pulmonary_circulatio0.79203332
120* MP0002116_abnormal_craniofacial_bone0.79140501
121MP0001216_abnormal_epidermal_layer0.77925427
122MP0005621_abnormal_cell_physiology0.77747127
123MP0002109_abnormal_limb_morphology0.77266171
124MP0010771_integument_phenotype0.76981023
125MP0002249_abnormal_larynx_morphology0.76627870
126MP0003448_altered_tumor_morphology0.70793155
127MP0005164_abnormal_response_to0.70340574
128* MP0000627_abnormal_mammary_gland0.69547668
129MP0009840_abnormal_foam_cell0.66429765
130MP0004087_abnormal_muscle_fiber0.66241361
131MP0005058_abnormal_lysosome_morphology0.65825356
132MP0002098_abnormal_vibrissa_morphology0.63679124

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.92286320
2Shallow orbits (HP:0000586)4.39055402
3Premature rupture of membranes (HP:0001788)4.28574601
4Atrophic scars (HP:0001075)3.69574534
5Cerebral aneurysm (HP:0004944)3.58158388
6Ankle contracture (HP:0006466)3.26065645
7Follicular hyperkeratosis (HP:0007502)3.13518551
8Buphthalmos (HP:0000557)3.01166802
9Mildly elevated creatine phosphokinase (HP:0008180)2.89598976
10Short 4th metacarpal (HP:0010044)2.88339107
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88339107
12Hyperacusis (HP:0010780)2.86088168
13Subacute progressive viral hepatitis (HP:0006572)2.84899829
14Cervical subluxation (HP:0003308)2.78379274
15Type 1 muscle fiber predominance (HP:0003803)2.72463386
16Distal lower limb amyotrophy (HP:0008944)2.72106224
17Aortic aneurysm (HP:0004942)2.71514748
18Aortic dissection (HP:0002647)2.71170075
19Achilles tendon contracture (HP:0001771)2.66634529
20Natal tooth (HP:0000695)2.64390318
21Fragile skin (HP:0001030)2.63103013
22Elbow flexion contracture (HP:0002987)2.63025394
23Coronal craniosynostosis (HP:0004440)2.57434053
24Rectal prolapse (HP:0002035)2.52805931
25Broad metatarsal (HP:0001783)2.47151418
26Mitral valve prolapse (HP:0001634)2.45565463
27Lymphangioma (HP:0100764)2.44175914
28Focal segmental glomerulosclerosis (HP:0000097)2.44152036
29Increased density of long bones (HP:0006392)2.42290566
30Dilatation of the ascending aorta (HP:0005111)2.42095812
31Bladder diverticulum (HP:0000015)2.41692657
32Genu recurvatum (HP:0002816)2.37175084
33Spondylolisthesis (HP:0003302)2.35559051
34Disproportionate tall stature (HP:0001519)2.35169709
35Soft skin (HP:0000977)2.34948769
36Abnormality of the Achilles tendon (HP:0005109)2.34934826
37Abnormality of the 4th metacarpal (HP:0010012)2.34264075
38Deviation of the hallux (HP:0010051)2.33907549
39Wormian bones (HP:0002645)2.30710025
40Abnormality of the distal phalanges of the toes (HP:0010182)2.30673743
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.29671239
42Osteolytic defects of the hand bones (HP:0009699)2.29671239
43Blue sclerae (HP:0000592)2.29324614
44Milia (HP:0001056)2.26817534
45Long toe (HP:0010511)2.26222856
46Joint laxity (HP:0001388)2.25888854
47Wrist flexion contracture (HP:0001239)2.24615278
48Peritonitis (HP:0002586)2.23082439
49Generalized amyotrophy (HP:0003700)2.22156943
50Arterial tortuosity (HP:0005116)2.22077391
51Vascular tortuosity (HP:0004948)2.22039259
52Congenital glaucoma (HP:0001087)2.20943899
53Short nail (HP:0001799)2.20709480
54Hallux valgus (HP:0001822)2.19742158
55Slender build (HP:0001533)2.19436119
56Aneurysm (HP:0002617)2.19342527
57Distal lower limb muscle weakness (HP:0009053)2.17657300
58Enlarged penis (HP:0000040)2.15260992
59Biconcave vertebral bodies (HP:0004586)2.14608540
60Spinal rigidity (HP:0003306)2.13522269
61Cardiovascular calcification (HP:0011915)2.13451665
62Abnormality of the umbilical cord (HP:0010881)2.10660002
63Lower limb amyotrophy (HP:0007210)2.10317931
64Absent frontal sinuses (HP:0002688)2.09587566
65Bronchomalacia (HP:0002780)2.09386559
66Insomnia (HP:0100785)2.09250977
67Spinal cord lesions (HP:0100561)2.09011876
68Syringomyelia (HP:0003396)2.09011876
69Increased variability in muscle fiber diameter (HP:0003557)2.08597176
70Radial bowing (HP:0002986)2.07954823
71Neonatal short-limb short stature (HP:0008921)2.07556045
72Thin bony cortex (HP:0002753)2.05795982
73Overgrowth (HP:0001548)2.04633463
74Abnormality of dentin (HP:0010299)2.03875793
75Asymmetry of the thorax (HP:0001555)2.03593867
76Hematochezia (HP:0002573)2.03483552
77Entropion (HP:0000621)2.03121994
78Hypoventilation (HP:0002791)2.02066337
79Selective tooth agenesis (HP:0001592)2.01727318
80Spastic diplegia (HP:0001264)2.01600586
81Glomerulosclerosis (HP:0000096)2.00832128
82Ulnar bowing (HP:0003031)2.00831152
83Deviation of the thumb (HP:0009603)1.99533567
84Back pain (HP:0003418)1.99367439
85Reduced subcutaneous adipose tissue (HP:0003758)1.97917724
86Turricephaly (HP:0000262)1.97474626
87Increased connective tissue (HP:0009025)1.97208510
88Advanced eruption of teeth (HP:0006288)1.96786777
89Malignant gastrointestinal tract tumors (HP:0006749)1.96769418
90Gastrointestinal carcinoma (HP:0002672)1.96769418
91Vertebral hypoplasia (HP:0008417)1.96360949
92Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.96360949
93Mitral stenosis (HP:0001718)1.94502592
94Bowel diverticulosis (HP:0005222)1.93804743
95Scapular winging (HP:0003691)1.92913084
96Difficulty climbing stairs (HP:0003551)1.92595052
97Aortic regurgitation (HP:0001659)1.92556181
98Hand muscle atrophy (HP:0009130)1.92261232
99Abnormality of oral frenula (HP:0000190)1.90265734
100Broad thumb (HP:0011304)1.90005779
101Abnormal ossification of hand bones (HP:0005921)1.88996982
102Ankyloglossia (HP:0010296)1.88250654
103Germ cell neoplasia (HP:0100728)1.86733106
104Micronodular cirrhosis (HP:0001413)1.85285651
105Abnormality of skeletal muscle fiber size (HP:0012084)1.84664331
106Exostoses (HP:0100777)1.84539775
107Broad face (HP:0000283)1.83417605
108Camptodactyly of toe (HP:0001836)1.83362919
109Protruding ear (HP:0000411)1.82341128
110Bowing of the arm (HP:0006488)1.81759069
111Bowed forearm bones (HP:0003956)1.81759069
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.81320900
113Wide anterior fontanel (HP:0000260)1.81067159
114Abnormal delivery (HP:0001787)1.80885148
115Arnold-Chiari malformation (HP:0002308)1.80345683
116Abnormality of carpal bone ossification (HP:0006257)1.79802695
117Interstitial pulmonary disease (HP:0006530)1.77567527
118Flat acetabular roof (HP:0003180)1.75862669
119Pterygium (HP:0001059)1.75029474
120Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74902598
121Abnormal vertebral ossification (HP:0100569)1.74819814
122Abnormality of the calcaneus (HP:0008364)1.74804711
123Abnormality of the acetabulum (HP:0003170)1.74737525
124Delayed cranial suture closure (HP:0000270)1.73618103
125Vertebral arch anomaly (HP:0008438)1.73502056
126Coxa vara (HP:0002812)1.72271195
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71408463
128Distal upper limb amyotrophy (HP:0007149)1.70583593
129Upper limb amyotrophy (HP:0009129)1.70583593
130Missing ribs (HP:0000921)1.68977927
131Renal duplication (HP:0000075)1.68906873
132Trismus (HP:0000211)1.68093688
133Abnormality of the anterior chamber (HP:0000593)1.67661681
134Uterine neoplasm (HP:0010784)1.67469078
135Colon cancer (HP:0003003)1.67182114
136Nuclear cataract (HP:0100018)1.66828281
137Hyperextensible skin (HP:0000974)1.66791550
138Broad long bones (HP:0005622)1.66594415
139Right ventricular cardiomyopathy (HP:0011663)1.66581557
140Joint stiffness (HP:0001387)1.66191943
141Vertebral compression fractures (HP:0002953)1.66079261
142Esophageal atresia (HP:0002032)1.64124476
143Leiomyosarcoma (HP:0100243)1.64015698
144Uterine leiomyosarcoma (HP:0002891)1.64015698
145Spinal cord compression (HP:0002176)1.63823816
146Mitral regurgitation (HP:0001653)1.63778215
147Mesomelia (HP:0003027)1.63661554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.70660116
2TRIB33.49266397
3TTN3.12812079
4PKN23.09926491
5LATS13.08444993
6MYLK2.37227025
7SIK12.34598224
8PAK42.33032217
9EPHB22.32547851
10PDGFRA2.32348104
11DDR22.32247251
12PTK62.15099652
13LRRK22.12431851
14NEK12.07177437
15RIPK12.01309288
16FER1.91779775
17PAK21.91774021
18EEF2K1.88287341
19PTK21.87489372
20BMX1.82419002
21MOS1.79587188
22IRAK31.76615605
23SMG11.76175696
24STK101.71053783
25TESK11.68482305
26TGFBR11.66647897
27CDK61.58118923
28MET1.52042596
29LATS21.48199526
30NEK91.41130251
31LMTK21.39798352
32SCYL21.31444006
33STK31.29301267
34RPS6KA41.28280349
35MAP3K81.27867217
36PRKD21.25988958
37MAP3K101.25650707
38FRK1.23675713
39STK381.23295597
40FGFR11.22299171
41LIMK11.19041281
42ERN11.14437653
43CDC71.11805328
44TGFBR21.08563185
45MTOR1.07840353
46PDGFRB1.06547437
47NEK21.04688041
48PAK31.04581798
49ILK1.04467320
50PASK1.04412679
51TESK21.03714729
52ERBB21.03206576
53PAK60.97913602
54AKT30.96545835
55CDK80.95765177
56RPS6KB20.93584123
57ROCK20.91317525
58ROCK10.88575435
59NTRK10.83833940
60ARAF0.83496746
61ABL20.83444080
62RPS6KA20.83048290
63PIM20.82182990
64ERBB40.80866689
65CDK70.79471485
66AURKB0.77143112
67NME20.76715208
68DMPK0.74663483
69CDK120.73257368
70EPHB10.71468506
71ERBB30.66210639
72TAOK20.65491105
73STK38L0.64755524
74CDC42BPA0.62507298
75TRPM70.62487918
76RET0.60462491
77MAP2K10.60240044
78MAPKAPK30.60063417
79MST1R0.57757659
80PBK0.57060325
81MKNK10.55744065
82EIF2AK10.54814592
83MUSK0.52815803
84PTK2B0.52105472
85BUB10.51704520
86EPHA30.50601116
87KDR0.50463848
88PRKD30.50388009
89PAK10.49654678
90FLT30.49531044
91MAP3K120.49473164
92TLK10.49070275
93CAMK1D0.48506318
94AKT20.47840691
95INSR0.47087662
96MAP3K20.46463723
97CDK140.46117259
98PLK30.44922734
99MAP3K60.44403735
100TTK0.44341465
101ICK0.43981791
102EGFR0.43914340
103ALK0.43241655
104AURKA0.43029653
105PRPF4B0.42630255
106BRSK20.42434492
107MELK0.41865691
108BRAF0.41043544
109PRKG20.41032222
110TYRO30.40597592
111DAPK30.40190220
112PLK20.40030297
113SRC0.39805338
114MAPKAPK20.38514184
115CDK150.37012834
116FGFR40.36637013
117MAP3K30.36454716
118MST40.35757942
119CDK90.35653145
120BRSK10.35601014
121PLK10.35276141
122CAMK2G0.33351940
123FGFR20.33022993
124PIK3CA0.32948451
125KSR10.32896378
126STK40.32871033
127CDK180.32745998
128CDK11A0.31665343
129MAP2K30.31417040
130HIPK20.29997903
131CHEK20.29720483
132CDK40.29643619

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.36360281
2Adherens junction_Homo sapiens_hsa045202.85699628
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.77680053
4* Small cell lung cancer_Homo sapiens_hsa052222.73067785
5* Focal adhesion_Homo sapiens_hsa045102.65078891
6* Proteoglycans in cancer_Homo sapiens_hsa052052.45004641
7* Hippo signaling pathway_Homo sapiens_hsa043902.24254606
8* Bladder cancer_Homo sapiens_hsa052192.17672554
9* MicroRNAs in cancer_Homo sapiens_hsa052062.14906027
10Basal cell carcinoma_Homo sapiens_hsa052172.06391635
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.02567190
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98205706
13* Chronic myeloid leukemia_Homo sapiens_hsa052201.84075906
14Amoebiasis_Homo sapiens_hsa051461.73116509
15* p53 signaling pathway_Homo sapiens_hsa041151.68386227
16TGF-beta signaling pathway_Homo sapiens_hsa043501.64193597
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.64003749
18Tight junction_Homo sapiens_hsa045301.63276148
19Hedgehog signaling pathway_Homo sapiens_hsa043401.59227491
20Systemic lupus erythematosus_Homo sapiens_hsa053221.56537526
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50974180
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50185519
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44751817
24* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44515925
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.42233802
26* Viral carcinogenesis_Homo sapiens_hsa052031.40245339
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37132500
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33153770
29Dilated cardiomyopathy_Homo sapiens_hsa054141.30584644
30* Pancreatic cancer_Homo sapiens_hsa052121.27291958
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24351087
32One carbon pool by folate_Homo sapiens_hsa006701.22265059
33Shigellosis_Homo sapiens_hsa051311.22035242
34* Viral myocarditis_Homo sapiens_hsa054161.21761252
35* Pathways in cancer_Homo sapiens_hsa052001.20688616
36* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20062459
37Vibrio cholerae infection_Homo sapiens_hsa051101.18272997
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.16133146
39* Cell cycle_Homo sapiens_hsa041101.15301367
40* Endometrial cancer_Homo sapiens_hsa052131.14574695
41Pentose phosphate pathway_Homo sapiens_hsa000301.14263827
42* Glioma_Homo sapiens_hsa052141.11768606
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11163814
44* Melanoma_Homo sapiens_hsa052181.08589757
45* Colorectal cancer_Homo sapiens_hsa052101.07440318
46Notch signaling pathway_Homo sapiens_hsa043301.07382372
47Protein digestion and absorption_Homo sapiens_hsa049741.06240626
48* Prostate cancer_Homo sapiens_hsa052151.04640941
49* HTLV-I infection_Homo sapiens_hsa051661.01672725
50Toxoplasmosis_Homo sapiens_hsa051451.00869218
51Other glycan degradation_Homo sapiens_hsa005110.98803699
52Nitrogen metabolism_Homo sapiens_hsa009100.98223804
53Renal cell carcinoma_Homo sapiens_hsa052110.97990110
54Axon guidance_Homo sapiens_hsa043600.97523883
55Rap1 signaling pathway_Homo sapiens_hsa040150.96186524
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92660197
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89404881
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88144591
59* Wnt signaling pathway_Homo sapiens_hsa043100.87023338
60mTOR signaling pathway_Homo sapiens_hsa041500.84402650
61* Thyroid cancer_Homo sapiens_hsa052160.82496481
62Galactose metabolism_Homo sapiens_hsa000520.82436645
63Platelet activation_Homo sapiens_hsa046110.81886221
64Selenocompound metabolism_Homo sapiens_hsa004500.78168579
65Melanogenesis_Homo sapiens_hsa049160.75844689
66Apoptosis_Homo sapiens_hsa042100.75568777
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.75522616
68HIF-1 signaling pathway_Homo sapiens_hsa040660.73876049
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73672230
70Alcoholism_Homo sapiens_hsa050340.70614567
71RNA transport_Homo sapiens_hsa030130.70062453
72VEGF signaling pathway_Homo sapiens_hsa043700.69648663
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.68951193
74Estrogen signaling pathway_Homo sapiens_hsa049150.68911276
75Lysine degradation_Homo sapiens_hsa003100.68881027
76Vitamin B6 metabolism_Homo sapiens_hsa007500.67702467
77Fructose and mannose metabolism_Homo sapiens_hsa000510.65801217
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.65743570
79* Non-small cell lung cancer_Homo sapiens_hsa052230.65135347
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64785380
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63733552
82Gap junction_Homo sapiens_hsa045400.62429043
83Salmonella infection_Homo sapiens_hsa051320.61470273
84* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59448660
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58691667
86Endocytosis_Homo sapiens_hsa041440.55406250
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55266366
88* Hepatitis B_Homo sapiens_hsa051610.55106185
89Sphingolipid metabolism_Homo sapiens_hsa006000.54065738
90ErbB signaling pathway_Homo sapiens_hsa040120.53224203
91N-Glycan biosynthesis_Homo sapiens_hsa005100.52586719
92Phagosome_Homo sapiens_hsa041450.52335723
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49939025
94Malaria_Homo sapiens_hsa051440.48234442
95Insulin resistance_Homo sapiens_hsa049310.47959470
96TNF signaling pathway_Homo sapiens_hsa046680.47527238
97Hepatitis C_Homo sapiens_hsa051600.47417005
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46467673
99GnRH signaling pathway_Homo sapiens_hsa049120.45297362
100Inositol phosphate metabolism_Homo sapiens_hsa005620.44622741
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43821728
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43603239
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.43465807
104Nucleotide excision repair_Homo sapiens_hsa034200.42283224
105Lysosome_Homo sapiens_hsa041420.41330353
106Glucagon signaling pathway_Homo sapiens_hsa049220.40661094
107Biosynthesis of amino acids_Homo sapiens_hsa012300.40027121
108Ras signaling pathway_Homo sapiens_hsa040140.39549895
109* FoxO signaling pathway_Homo sapiens_hsa040680.39542585
110Pertussis_Homo sapiens_hsa051330.39005333
111Prion diseases_Homo sapiens_hsa050200.37694282
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36396347
113Insulin signaling pathway_Homo sapiens_hsa049100.35958350
114* AMPK signaling pathway_Homo sapiens_hsa041520.35640266
115Legionellosis_Homo sapiens_hsa051340.33570738
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32239845
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32207890
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31824719
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31131672
120Thyroid hormone synthesis_Homo sapiens_hsa049180.31033724
121* Prolactin signaling pathway_Homo sapiens_hsa049170.30979806
122Renin-angiotensin system_Homo sapiens_hsa046140.30648161

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