CCND3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.58735173
2negative regulation of cell killing (GO:0031342)5.58735173
3antigen processing and presentation of endogenous antigen (GO:0019883)5.54225066
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.42489377
5viral transcription (GO:0019083)5.05180255
6neutrophil activation involved in immune response (GO:0002283)5.04406876
7ribosomal small subunit assembly (GO:0000028)4.99914340
8translational termination (GO:0006415)4.83718513
9regulation of B cell receptor signaling pathway (GO:0050855)4.72709426
10DNA strand elongation involved in DNA replication (GO:0006271)4.68783319
11DNA unwinding involved in DNA replication (GO:0006268)4.59336642
12telomere maintenance via semi-conservative replication (GO:0032201)4.53212251
13DNA strand elongation (GO:0022616)4.46007576
14negative thymic T cell selection (GO:0045060)4.43271175
15negative T cell selection (GO:0043383)4.40743120
16translational elongation (GO:0006414)4.33052152
17positive thymic T cell selection (GO:0045059)4.30630165
18DNA replication initiation (GO:0006270)4.25590515
19maturation of SSU-rRNA (GO:0030490)4.22114941
20positive regulation by symbiont of host defense response (GO:0052509)4.20017781
21modulation by symbiont of host defense response (GO:0052031)4.20017781
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.20017781
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.20017781
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.20017781
25modulation by symbiont of host immune response (GO:0052553)4.20017781
26positive regulation of granulocyte differentiation (GO:0030854)4.15120393
27ribosomal small subunit biogenesis (GO:0042274)4.11218395
28detection of bacterium (GO:0016045)4.08964165
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.04988390
30detection of other organism (GO:0098543)4.04292834
31DNA deamination (GO:0045006)3.94557426
32cotranslational protein targeting to membrane (GO:0006613)3.93640002
33protein targeting to ER (GO:0045047)3.93315163
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92328092
35response to interleukin-15 (GO:0070672)3.88795062
36translational initiation (GO:0006413)3.87884079
37B cell receptor signaling pathway (GO:0050853)3.84552727
38thymic T cell selection (GO:0045061)3.83051407
39telomere maintenance via recombination (GO:0000722)3.80762572
40viral life cycle (GO:0019058)3.78920305
41T cell selection (GO:0045058)3.77895224
42positive T cell selection (GO:0043368)3.77684633
43immunoglobulin mediated immune response (GO:0016064)3.74169677
44response to peptidoglycan (GO:0032494)3.73250854
45cellular protein complex disassembly (GO:0043624)3.72847195
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.71176853
47protein localization to endoplasmic reticulum (GO:0070972)3.65590874
48neutrophil activation (GO:0042119)3.64007163
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.60718080
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.58534439
51mitotic recombination (GO:0006312)3.57506412
52regulation of mast cell degranulation (GO:0043304)3.56548073
53regulation of B cell differentiation (GO:0045577)3.53502973
54cellular response to interleukin-15 (GO:0071350)3.51572058
55T cell migration (GO:0072678)3.49700069
56protein complex disassembly (GO:0043241)3.48521101
57antigen processing and presentation via MHC class Ib (GO:0002475)3.47778038
58tolerance induction (GO:0002507)3.46757054
59DNA replication checkpoint (GO:0000076)3.45420736
60protein localization to kinetochore (GO:0034501)3.41144595
61leukocyte degranulation (GO:0043299)3.40038056
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36837746
63negative regulation of leukocyte mediated immunity (GO:0002704)3.36627595
64granulocyte activation (GO:0036230)3.33879738
65formation of translation preinitiation complex (GO:0001731)3.32773579
66myeloid cell activation involved in immune response (GO:0002275)3.30382548
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.29794171
68telomere maintenance via telomere lengthening (GO:0010833)3.29316893
69negative regulation of T cell mediated immunity (GO:0002710)3.28450422
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26351584
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.25744881
72mucosal-associated lymphoid tissue development (GO:0048537)3.24105766
73Peyers patch development (GO:0048541)3.24105766
74regulation of alpha-beta T cell proliferation (GO:0046640)3.22585202
75respiratory burst (GO:0045730)3.21703654
76macrophage activation involved in immune response (GO:0002281)3.21504240
77macromolecular complex disassembly (GO:0032984)3.20905491
78regulation of mast cell activation involved in immune response (GO:0033006)3.19736493
79regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18724886
80response to muramyl dipeptide (GO:0032495)3.16997848
81N-acetylneuraminate metabolic process (GO:0006054)3.16366757
82leukocyte migration involved in inflammatory response (GO:0002523)3.14902904
83regulation of protein heterodimerization activity (GO:0043497)3.13807636
84protein localization to chromosome, centromeric region (GO:0071459)3.13758971
85regulation of leukocyte degranulation (GO:0043300)3.13178502
86regulation of natural killer cell mediated immunity (GO:0002715)3.12686841
87regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.12686841
88ribosomal large subunit biogenesis (GO:0042273)3.11921391
89regulation of granulocyte differentiation (GO:0030852)3.11804205
90B cell mediated immunity (GO:0019724)3.11459284
91regulation of T cell tolerance induction (GO:0002664)3.11130902
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10813734
93response to host immune response (GO:0052572)3.10813734
94negative regulation of interleukin-12 production (GO:0032695)3.08076983
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07788925
96detection of external biotic stimulus (GO:0098581)3.07114039
97megakaryocyte development (GO:0035855)3.06520429
98positive regulation of gamma-delta T cell activation (GO:0046645)3.06216904
99type I interferon signaling pathway (GO:0060337)3.03879886
100cellular response to type I interferon (GO:0071357)3.03879886
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03770667
102nuclear-transcribed mRNA catabolic process (GO:0000956)3.02711611
103mast cell activation (GO:0045576)3.02167724
104Arp2/3 complex-mediated actin nucleation (GO:0034314)3.02162139
1053-UTR-mediated mRNA stabilization (GO:0070935)3.02003300
106response to type I interferon (GO:0034340)3.01726536
107positive regulation of mast cell activation (GO:0033005)2.96965353
108regulation of interferon-beta biosynthetic process (GO:0045357)2.96037546
109antigen receptor-mediated signaling pathway (GO:0050851)2.95709696
110regulation of tolerance induction (GO:0002643)2.93791769
111negative regulation of RNA splicing (GO:0033119)2.93649117
112negative regulation of phagocytosis (GO:0050765)2.91887237
113response to host (GO:0075136)2.91834592
114response to host defenses (GO:0052200)2.91834592
115response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91834592
116V(D)J recombination (GO:0033151)2.90003172
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89016202
118mRNA catabolic process (GO:0006402)2.86378391
119regulation of mast cell activation (GO:0033003)2.85615990
120RNA catabolic process (GO:0006401)2.83889106
121regulation of regulatory T cell differentiation (GO:0045589)2.79505998
122amino sugar catabolic process (GO:0046348)2.79015543
123DNA replication-dependent nucleosome organization (GO:0034723)2.78391972
124DNA replication-dependent nucleosome assembly (GO:0006335)2.78391972
125translation (GO:0006412)2.77885712
126defense response to protozoan (GO:0042832)2.76708099
127leukocyte aggregation (GO:0070486)2.76673577
128germinal center formation (GO:0002467)2.76529809
129negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76366825
130negative regulation of T-helper cell differentiation (GO:0045623)2.76366825
131regulation of platelet aggregation (GO:0090330)2.76185160
132positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75601106
133positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75543407
134regulation of T cell mediated cytotoxicity (GO:0001914)2.75351295
135negative regulation of innate immune response (GO:0045824)2.73364463
136positive regulation of isotype switching (GO:0045830)2.73048120
137establishment of integrated proviral latency (GO:0075713)2.72824341
138regulation of interleukin-2 biosynthetic process (GO:0045076)2.71424674
139folic acid-containing compound biosynthetic process (GO:0009396)2.70661097
140lymphocyte homeostasis (GO:0002260)2.69564172
141regulation of gamma-delta T cell differentiation (GO:0045586)2.68920796
142T cell receptor signaling pathway (GO:0050852)2.68724867
143DNA ligation (GO:0006266)2.65603832
144mitotic nuclear envelope disassembly (GO:0007077)2.64538599
145ribonucleoprotein complex biogenesis (GO:0022613)2.62117975
146mitotic sister chromatid segregation (GO:0000070)2.60821554
147sequestering of actin monomers (GO:0042989)2.58920123
148IMP biosynthetic process (GO:0006188)2.58768407
149GMP metabolic process (GO:0046037)2.58752673
150erythrocyte maturation (GO:0043249)2.58645686
151protein targeting to membrane (GO:0006612)2.57088342
152peptidyl-arginine omega-N-methylation (GO:0035247)2.57065327
153DNA duplex unwinding (GO:0032508)2.54417273
154DNA geometric change (GO:0032392)2.53427515
155antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52844405
156antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52844405
157negative regulation of mRNA processing (GO:0050686)2.52684931
158negative regulation of erythrocyte differentiation (GO:0045647)2.52676329
159morphogenesis of an endothelium (GO:0003159)2.52251787
160endothelial tube morphogenesis (GO:0061154)2.52251787
161heterochromatin organization (GO:0070828)2.52130493
162T cell apoptotic process (GO:0070231)2.50884472
163DNA damage response, detection of DNA damage (GO:0042769)2.50402528
164positive regulation of B cell differentiation (GO:0045579)2.49971070
165T cell homeostasis (GO:0043029)2.49891220
166translesion synthesis (GO:0019985)2.48328900
167rRNA processing (GO:0006364)2.46840236
168base-excision repair (GO:0006284)2.46031676
169regulation of histone H3-K9 methylation (GO:0051570)2.45592168
170regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44646487
171telomere organization (GO:0032200)2.44254185
172telomere maintenance (GO:0000723)2.42876435
173RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.40308809
174mRNA splicing, via spliceosome (GO:0000398)2.40308809
175transcription-coupled nucleotide-excision repair (GO:0006283)2.40067883
176spliceosomal snRNP assembly (GO:0000387)2.39979850
177somatic cell DNA recombination (GO:0016444)2.39886289
178somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.39886289
179RNA splicing, via transesterification reactions (GO:0000375)2.39294426
180rRNA metabolic process (GO:0016072)2.38366835
181cellular extravasation (GO:0045123)2.37961269
182sister chromatid segregation (GO:0000819)2.37724768
183membrane disassembly (GO:0030397)2.37714414
184nuclear envelope disassembly (GO:0051081)2.37714414
185regulation of gamma-delta T cell activation (GO:0046643)2.35183224
186CENP-A containing nucleosome assembly (GO:0034080)2.33760892
187regulation of double-strand break repair via homologous recombination (GO:0010569)2.33241014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83122463
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94223590
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.64649725
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.14407559
5MYC_22102868_ChIP-Seq_BL_Human3.02967272
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95133212
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76193688
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64419392
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.59970075
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55993804
11VDR_21846776_ChIP-Seq_THP-1_Human2.38062474
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35124244
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28410887
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23899684
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20881326
16* RUNX_20019798_ChIP-Seq_JUKART_Human2.20622033
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20301991
18SPI1_23127762_ChIP-Seq_K562_Human2.19350786
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19336557
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11084067
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.02094033
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01743620
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.00104734
24XRN2_22483619_ChIP-Seq_HELA_Human1.99262811
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97993894
26* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.95984148
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.95151812
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.94961265
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90239751
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88751016
31CIITA_25753668_ChIP-Seq_RAJI_Human1.83292573
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82220905
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81953474
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81896711
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81127566
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.77807595
37* SCL_19346495_ChIP-Seq_HPC-7_Human1.76399498
38* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75489313
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73006605
40VDR_23849224_ChIP-Seq_CD4+_Human1.70830796
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70807686
42MAF_26560356_Chip-Seq_TH1_Human1.69929472
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69185806
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68348105
45* LXR_22292898_ChIP-Seq_THP-1_Human1.67941699
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65903112
47* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65840986
48* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64020706
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63839397
50* GATA1_19941826_ChIP-Seq_K562_Human1.62348384
51* UTX_26944678_Chip-Seq_JUKART_Human1.61598866
52FOXP3_21729870_ChIP-Seq_TREG_Human1.60858107
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.59932362
54* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54741565
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.53091397
56* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50590895
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49123184
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48450499
59GATA3_27048872_Chip-Seq_THYMUS_Human1.48002956
60SPI1_23547873_ChIP-Seq_NB4_Human1.46858356
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46580070
62NCOR1_26117541_ChIP-Seq_K562_Human1.45184847
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45075968
64DCP1A_22483619_ChIP-Seq_HELA_Human1.43124977
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41945654
66TTF2_22483619_ChIP-Seq_HELA_Human1.40974716
67* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40670585
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40131813
69* MYB_26560356_Chip-Seq_TH2_Human1.39680887
70GABP_19822575_ChIP-Seq_HepG2_Human1.37913865
71* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37654843
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37522257
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36934899
74GATA1_22025678_ChIP-Seq_K562_Human1.36911287
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36300517
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34825832
77* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33046699
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33002531
79* VDR_24763502_ChIP-Seq_THP-1_Human1.31922885
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31775370
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31768741
82* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31265823
83* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30755817
84* TCF7_22412390_ChIP-Seq_EML_Mouse1.29645213
85BCL6_27268052_Chip-Seq_Bcells_Human1.29090601
86* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28724704
87* MYB_26560356_Chip-Seq_TH1_Human1.28425025
88* RUNX1_22412390_ChIP-Seq_EML_Mouse1.27729387
89* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27661337
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.27380066
91MAF_26560356_Chip-Seq_TH2_Human1.27099749
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25628079
93BCOR_27268052_Chip-Seq_Bcells_Human1.25173931
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23643151
95* KDM2B_26808549_Chip-Seq_JURKAT_Human1.23493676
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23127859
97* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21950715
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21576760
99* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21422059
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20681848
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20665913
102AR_21909140_ChIP-Seq_LNCAP_Human1.20103242
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19851400
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19412458
105THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18361941
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.17891074
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16244158
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15733764
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15264064
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12013856
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11866039
112P68_20966046_ChIP-Seq_HELA_Human1.11859776
113* GATA2_19941826_ChIP-Seq_K562_Human1.11217819
114* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10389240
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10163149
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09403786
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09356466
118* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08783420
119* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08010447
120IRF8_22096565_ChIP-ChIP_GC-B_Human1.07831831
121KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07776206
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06929826
123RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06773664
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06753205
125* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06301540
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.06123442
127ELK1_19687146_ChIP-ChIP_HELA_Human1.05475698
128KDM5A_27292631_Chip-Seq_BREAST_Human1.05394677
129* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05310315
130* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03937552
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03531472
132CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02570351
133SA1_27219007_Chip-Seq_ERYTHROID_Human1.01788858
134* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01695698
135RACK7_27058665_Chip-Seq_MCF-7_Human1.01541301
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01389671
137* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00690743
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00322501
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99327524
140BP1_19119308_ChIP-ChIP_Hs578T_Human0.99141841
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98273444
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.97870188
143KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96957538
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96890055
145* KDM2B_26808549_Chip-Seq_DND41_Human0.94751622
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94731587
147PU_27001747_Chip-Seq_BMDM_Mouse0.94663350
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94519887
149* GATA3_26560356_Chip-Seq_TH2_Human0.93817224
150CTCF_26484167_Chip-Seq_Bcells_Mouse0.93470065
151Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92619483
152IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92616750
153SPI1_20517297_ChIP-Seq_HL60_Human0.92019997
154CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89997859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.64047007
2MP0010094_abnormal_chromosome_stability3.03460674
3MP0003111_abnormal_nucleus_morphology2.93491255
4MP0002396_abnormal_hematopoietic_system2.85944019
5MP0004957_abnormal_blastocyst_morpholog2.75155487
6MP0003763_abnormal_thymus_physiology2.68282587
7MP0003077_abnormal_cell_cycle2.61115133
8MP0000685_abnormal_immune_system2.38442004
9MP0005397_hematopoietic_system_phenotyp2.32940902
10MP0001545_abnormal_hematopoietic_system2.32940902
11MP0009278_abnormal_bone_marrow2.32355181
12MP0000490_abnormal_crypts_of2.32128008
13MP0004808_abnormal_hematopoietic_stem2.24911368
14MP0009333_abnormal_splenocyte_physiolog2.19675253
15* MP0002398_abnormal_bone_marrow2.17793039
16MP0003191_abnormal_cellular_cholesterol2.01463567
17* MP0002722_abnormal_immune_system1.96548398
18MP0000689_abnormal_spleen_morphology1.95655076
19MP0008007_abnormal_cellular_replicative1.94702318
20MP0001800_abnormal_humoral_immune1.93186028
21MP0008057_abnormal_DNA_replication1.92630239
22MP0005671_abnormal_response_to1.89727783
23* MP0000703_abnormal_thymus_morphology1.87829000
24MP0006082_CNS_inflammation1.86889076
25MP0003436_decreased_susceptibility_to1.81935059
26MP0003656_abnormal_erythrocyte_physiolo1.81593642
27MP0002132_abnormal_respiratory_system1.73364645
28MP0009785_altered_susceptibility_to1.72588027
29MP0008058_abnormal_DNA_repair1.72473014
30MP0005451_abnormal_body_composition1.70024838
31MP0003172_abnormal_lysosome_physiology1.68139979
32* MP0002420_abnormal_adaptive_immunity1.66090811
33* MP0002429_abnormal_blood_cell1.65309877
34* MP0000716_abnormal_immune_system1.64920266
35* MP0001819_abnormal_immune_cell1.63784195
36MP0005058_abnormal_lysosome_morphology1.60364483
37MP0000465_gastrointestinal_hemorrhage1.60351386
38MP0002452_abnormal_antigen_presenting1.60012716
39MP0001835_abnormal_antigen_presentation1.58004411
40* MP0002019_abnormal_tumor_incidence1.55922889
41MP0002405_respiratory_system_inflammati1.53076486
42MP0003303_peritoneal_inflammation1.52061591
43MP0010352_gastrointestinal_tract_polyps1.48807306
44MP0002723_abnormal_immune_serum1.48340395
45MP0005025_abnormal_response_to1.47396042
46MP0006054_spinal_hemorrhage1.46884792
47MP0000350_abnormal_cell_proliferation1.44097490
48MP0005464_abnormal_platelet_physiology1.40702490
49MP0001851_eye_inflammation1.40623179
50MP0008932_abnormal_embryonic_tissue1.38949984
51MP0000858_altered_metastatic_potential1.38789637
52MP0005000_abnormal_immune_tolerance1.37611100
53MP0001730_embryonic_growth_arrest1.34616844
54MP0003786_premature_aging1.33141579
55MP0010155_abnormal_intestine_physiology1.32155771
56MP0010307_abnormal_tumor_latency1.31204435
57MP0005387_immune_system_phenotype1.26062586
58MP0001790_abnormal_immune_system1.26062586
59MP0008469_abnormal_protein_level1.24887401
60MP0005310_abnormal_salivary_gland1.21064056
61MP0005409_darkened_coat_color1.19844648
62MP0000313_abnormal_cell_death1.19579097
63MP0002166_altered_tumor_susceptibility1.19574089
64MP0004510_myositis1.18885686
65MP0003724_increased_susceptibility_to1.17360962
66MP0002080_prenatal_lethality1.11048850
67MP0005075_abnormal_melanosome_morpholog1.09747349
68MP0003567_abnormal_fetal_cardiomyocyte1.08037831
69MP0009764_decreased_sensitivity_to1.07864566
70MP0001853_heart_inflammation1.06950785
71MP0002998_abnormal_bone_remodeling1.04916464
72MP0002419_abnormal_innate_immunity1.04225823
73MP0001697_abnormal_embryo_size1.03995730
74MP0008004_abnormal_stomach_pH1.03038838
75MP0005023_abnormal_wound_healing1.01794915
76MP0005174_abnormal_tail_pigmentation1.01488669
77MP0005083_abnormal_biliary_tract1.01011722
78MP0003075_altered_response_to1.00588895
79MP0002933_joint_inflammation1.00185089
80MP0003866_abnormal_defecation0.98021564
81MP0001672_abnormal_embryogenesis/_devel0.96125234
82MP0005380_embryogenesis_phenotype0.96125234
83MP0003566_abnormal_cell_adhesion0.95378660
84MP0004381_abnormal_hair_follicle0.94261235
85MP0003984_embryonic_growth_retardation0.93884043
86MP0000343_altered_response_to0.93565151
87MP0009379_abnormal_foot_pigmentation0.93305794
88MP0009763_increased_sensitivity_to0.92929873
89MP0002086_abnormal_extraembryonic_tissu0.91736151
90MP0002088_abnormal_embryonic_growth/wei0.91187738
91MP0003123_paternal_imprinting0.90328089
92MP0003136_yellow_coat_color0.88678867
93MP0003828_pulmonary_edema0.88601464
94MP0000477_abnormal_intestine_morphology0.88374644
95MP0001845_abnormal_inflammatory_respons0.88362759
96MP0001873_stomach_inflammation0.87900534
97MP0004147_increased_porphyrin_level0.87142819
98MP0001915_intracranial_hemorrhage0.86725402
99MP0002085_abnormal_embryonic_tissue0.86393122
100MP0002095_abnormal_skin_pigmentation0.86392152
101MP0004197_abnormal_fetal_growth/weight/0.85527854
102MP0005166_decreased_susceptibility_to0.85398585
103MP0004883_abnormal_blood_vessel0.84309718
104MP0000015_abnormal_ear_pigmentation0.83618963
105MP0004947_skin_inflammation0.83456626
106MP0002877_abnormal_melanocyte_morpholog0.83371491
107MP0002006_tumorigenesis0.81946386
108MP0001663_abnormal_digestive_system0.80706073
109MP0002009_preneoplasia0.80213677
110MP0003300_gastrointestinal_ulcer0.79220992
111MP0002148_abnormal_hypersensitivity_rea0.77628729
112MP0009840_abnormal_foam_cell0.75751662
113MP0002160_abnormal_reproductive_system0.72677796
114MP0005390_skeleton_phenotype0.71566811
115MP0001533_abnormal_skeleton_physiology0.71047514
116MP0003448_altered_tumor_morphology0.70656182
117MP0003795_abnormal_bone_structure0.70122612
118MP0009765_abnormal_xenobiotic_induced0.69929578
119MP0009931_abnormal_skin_appearance0.68705762
120MP0000249_abnormal_blood_vessel0.67629655
121MP0003183_abnormal_peptide_metabolism0.67081623
122MP0008874_decreased_physiological_sensi0.66956068
123MP0003315_abnormal_perineum_morphology0.66567395
124MP0008260_abnormal_autophagy0.64489749
125MP0003279_aneurysm0.62162931
126MP0003806_abnormal_nucleotide_metabolis0.62123627
127MP0003045_fibrosis0.61815906
128MP0005076_abnormal_cell_differentiation0.61078670
129MP0005164_abnormal_response_to0.60254088
130MP0002084_abnormal_developmental_patter0.59298433
131MP0004185_abnormal_adipocyte_glucose0.57010661
132MP0001849_ear_inflammation0.54459906
133MP0003091_abnormal_cell_migration0.51900151
134MP0005621_abnormal_cell_physiology0.51179064
135MP0000609_abnormal_liver_physiology0.50191619
136MP0000604_amyloidosis0.47169728
137MP0004130_abnormal_muscle_cell0.46194230
138MP0005381_digestive/alimentary_phenotyp0.45529009
139MP0003453_abnormal_keratinocyte_physiol0.45228127

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.87460539
2Abnormality of cells of the erythroid lineage (HP:0012130)4.70760830
3Abnormality of macrophages (HP:0004311)4.56990003
4Recurrent bacterial skin infections (HP:0005406)4.55054602
5Abnormal number of erythroid precursors (HP:0012131)4.54067346
6Myositis (HP:0100614)4.35799209
7Stomatitis (HP:0010280)4.14881479
8Reticulocytopenia (HP:0001896)3.96212448
9Cellulitis (HP:0100658)3.76382590
10Increased IgE level (HP:0003212)3.66829983
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.59639140
12Orchitis (HP:0100796)3.56812511
13IgM deficiency (HP:0002850)3.53268291
14Agammaglobulinemia (HP:0004432)3.49050054
15Gastrointestinal infarctions (HP:0005244)3.42035886
16Purpura (HP:0000979)3.36617697
17Recurrent gram-negative bacterial infections (HP:0005420)3.33955339
18Encephalitis (HP:0002383)3.33284722
19Panhypogammaglobulinemia (HP:0003139)3.28578051
20Abnormal platelet volume (HP:0011876)3.27574683
21Optic neuritis (HP:0100653)3.22320586
22Retrobulbar optic neuritis (HP:0100654)3.22320586
23Abnormality of B cell number (HP:0010975)3.18308566
24B lymphocytopenia (HP:0010976)3.18308566
25Meningitis (HP:0001287)3.06956612
26Recurrent skin infections (HP:0001581)3.04319565
27Combined immunodeficiency (HP:0005387)3.02031951
28Papilloma (HP:0012740)3.00882731
29Verrucae (HP:0200043)3.00882731
30T lymphocytopenia (HP:0005403)3.00293844
31Petechiae (HP:0000967)2.97811894
32Severe combined immunodeficiency (HP:0004430)2.96949316
33Increased IgM level (HP:0003496)2.96357567
34Vasculitis (HP:0002633)2.96214289
35Gingival bleeding (HP:0000225)2.96097287
36Thyroiditis (HP:0100646)2.90635649
37Pallor (HP:0000980)2.87865168
38Recurrent bronchitis (HP:0002837)2.84622227
39Macrocytic anemia (HP:0001972)2.84224468
40Autoimmune hemolytic anemia (HP:0001890)2.83517510
41Recurrent viral infections (HP:0004429)2.81371205
42Microcytic anemia (HP:0001935)2.81281905
43Type I transferrin isoform profile (HP:0003642)2.80786381
44Abnormality of T cell number (HP:0011839)2.80248839
45Menorrhagia (HP:0000132)2.80230697
46Abnormality of T cells (HP:0002843)2.76600935
47Prolonged bleeding time (HP:0003010)2.76285198
48Urticaria (HP:0001025)2.74093723
49Chest pain (HP:0100749)2.69760204
50Gingivitis (HP:0000230)2.68088858
51Increased mean platelet volume (HP:0011877)2.66346489
52Spontaneous hematomas (HP:0007420)2.64172364
53Thrombocytosis (HP:0001894)2.57217545
54Recurrent fungal infections (HP:0002841)2.55703072
55Hepatosplenomegaly (HP:0001433)2.54765380
56Basal cell carcinoma (HP:0002671)2.53495718
57Episodic fever (HP:0001954)2.51503017
58Hypertensive crisis (HP:0100735)2.49475307
59Hypergammaglobulinemia (HP:0010702)2.47118547
60Reduced antithrombin III activity (HP:0001976)2.46510712
61Keratoconjunctivitis sicca (HP:0001097)2.46106805
62Colitis (HP:0002583)2.45464783
63Lymphoma (HP:0002665)2.40283841
64Abnormality of the nasal mucosa (HP:0000433)2.40163376
65Increased serum ferritin (HP:0003281)2.39572285
66Elevated erythrocyte sedimentation rate (HP:0003565)2.38905577
67Hypochromic microcytic anemia (HP:0004840)2.35731430
68Pulmonary infiltrates (HP:0002113)2.32152666
69Birth length less than 3rd percentile (HP:0003561)2.31178022
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30878864
71Absent thumb (HP:0009777)2.29973937
72Abnormality of reticulocytes (HP:0004312)2.29733595
73Abnormality of T cell physiology (HP:0011840)2.28979291
74Aplastic anemia (HP:0001915)2.26852385
75Arterial thrombosis (HP:0004420)2.26591484
76Keratoconjunctivitis (HP:0001096)2.21755711
77Selective tooth agenesis (HP:0001592)2.20202794
78Fatigue (HP:0012378)2.19635035
79Patellar aplasia (HP:0006443)2.15603539
80Muscle fiber atrophy (HP:0100295)2.15428939
81Abnormality of iron homeostasis (HP:0011031)2.15428384
82Hemoptysis (HP:0002105)2.14675060
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.14511532
84Chronic otitis media (HP:0000389)2.14403148
85Amaurosis fugax (HP:0100576)2.12603231
86Hypoplasia of the thymus (HP:0000778)2.12354077
87Skin ulcer (HP:0200042)2.11979096
88Breast hypoplasia (HP:0003187)2.09664451
89Epistaxis (HP:0000421)2.07131072
90Autoimmune thrombocytopenia (HP:0001973)2.07077041
91Recurrent abscess formation (HP:0002722)2.06899850
92Acute hepatic failure (HP:0006554)2.06387121
93Anorexia (HP:0002039)2.05963274
94Aplasia/Hypoplasia of the patella (HP:0006498)2.04594339
95Gastrointestinal inflammation (HP:0004386)2.04471975
96Aplasia/Hypoplasia of the thymus (HP:0010515)2.04163336
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03736545
98IgG deficiency (HP:0004315)2.02765592
99Granulocytopenia (HP:0001913)2.01713075
100Nasal polyposis (HP:0100582)2.00922154
101Myelodysplasia (HP:0002863)2.00388939
102Gastrointestinal stroma tumor (HP:0100723)1.99371842
103Abnormal platelet function (HP:0011869)1.98197551
104Impaired platelet aggregation (HP:0003540)1.98197551
105Microretrognathia (HP:0000308)1.96933466
106Pulmonary embolism (HP:0002204)1.96799461
107Trismus (HP:0000211)1.96667852
108Joint swelling (HP:0001386)1.96476491
109Abnormality of cells of the lymphoid lineage (HP:0012140)1.96428319
110Chronic obstructive pulmonary disease (HP:0006510)1.95875121
111Obstructive lung disease (HP:0006536)1.95875121
112Meckel diverticulum (HP:0002245)1.95529686
113Abnormality of the ileum (HP:0001549)1.94303444
114Eosinophilia (HP:0001880)1.93732161
115Hypochromic anemia (HP:0001931)1.93430601
116Slow saccadic eye movements (HP:0000514)1.91797122
117Progressive muscle weakness (HP:0003323)1.89975954
118Lymphopenia (HP:0001888)1.89883118
119Hypertriglyceridemia (HP:0002155)1.89472383
120Increased density of long bones (HP:0006392)1.88041238
121Hypoproteinemia (HP:0003075)1.87804743
122Abnormal protein glycosylation (HP:0012346)1.86631074
123Abnormal glycosylation (HP:0012345)1.86631074
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86631074
125Abnormal protein N-linked glycosylation (HP:0012347)1.86631074
126Abnormality of the fingertips (HP:0001211)1.85369477
127Polycythemia (HP:0001901)1.84891542
128Skin rash (HP:0000988)1.82800128
129Inflammation of the large intestine (HP:0002037)1.81261178
130Recurrent cutaneous fungal infections (HP:0011370)1.80859104
131Chronic mucocutaneous candidiasis (HP:0002728)1.80859104
132High pitched voice (HP:0001620)1.80630889
133Abnormality of eosinophils (HP:0001879)1.79614626
134Mediastinal lymphadenopathy (HP:0100721)1.78701666
135Leukocytosis (HP:0001974)1.78637524
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78619414
137Sepsis (HP:0100806)1.78036979
138Bone marrow hypocellularity (HP:0005528)1.77489087
139Type 2 muscle fiber atrophy (HP:0003554)1.76563868
140Hypercortisolism (HP:0001578)1.76120275
141Neoplasm of the pancreas (HP:0002894)1.74049612
142Pustule (HP:0200039)1.73747228
143Osteomyelitis (HP:0002754)1.72101863
144Acute lymphatic leukemia (HP:0006721)1.71374880
145Poikilocytosis (HP:0004447)1.70361902
14611 pairs of ribs (HP:0000878)1.69164739
147Multiple enchondromatosis (HP:0005701)1.68564391
148Abnormal number of incisors (HP:0011064)1.67317471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.54749216
2MAP3K103.62033641
3NME23.55895316
4PRPF4B3.19511415
5EEF2K3.17930447
6MAP4K12.90106280
7BUB12.66961097
8WEE12.52392341
9TLK12.45408064
10KDR2.39452071
11PKN22.30206628
12TESK22.18872751
13NEK22.14645489
14STK102.11594190
15CDC72.09190117
16PASK1.89374990
17TRIB31.87756226
18BTK1.82450348
19TAOK31.72534413
20BLK1.71591714
21GRK61.69397024
22RPS6KB21.68698743
23MKNK21.65496581
24CLK11.62465918
25ERN11.60025264
26ZAP701.59966946
27MAP3K131.58344173
28MAP3K31.51818348
29SMG11.49510643
30CDK41.48150944
31FLT31.46589749
32RPS6KA41.45335406
33MAP3K141.44581720
34LRRK21.43816838
35TEC1.41863683
36PIM21.39014547
37NLK1.38822620
38DYRK31.38295721
39EPHB11.36526118
40SIK31.34444648
41TAOK21.34245971
42CDK71.33086630
43STK41.26278628
44MAPKAPK31.26191759
45PIM11.25938531
46MKNK11.25400966
47EIF2AK11.24543014
48JAK11.18994713
49MAP3K81.17579746
50TAOK11.14992496
51MAP3K111.14468925
52SRPK11.13403288
53MAP3K11.13266136
54JAK21.11245277
55TGFBR11.07736521
56BMPR21.07284740
57AURKB1.05423722
58IRAK41.04737486
59KSR21.02491807
60EIF2AK31.01132669
61PAK41.00889189
62MARK30.98477414
63SYK0.98236044
64SIK20.96447176
65VRK10.95504521
66PDK10.92071482
67SIK10.89333003
68CSK0.88533965
69FES0.87364300
70MAP2K30.86650246
71PLK10.86586776
72JAK30.86528977
73TTK0.84677927
74FGR0.84500807
75BMX0.83221206
76MARK20.81710617
77TESK10.80292165
78TGFBR20.78721961
79CDK120.77378220
80TIE10.77274537
81PDPK10.76890374
82ATR0.76462738
83FGFR40.75840289
84TXK0.75395100
85LCK0.74811502
86TYK20.71951465
87AURKA0.70959319
88PTK60.70503206
89LYN0.70235945
90MAPK40.70173786
91CSF1R0.69826452
92IRAK30.69702547
93ITK0.69475009
94ACVR1B0.69130362
95STK160.68386193
96BRSK20.63883691
97PRKD20.62087352
98PRKCQ0.61492757
99HCK0.59355309
100CAMKK10.58514334
101CDK60.58289627
102RAF10.57551496
103MAP3K60.56460395
104SCYL20.56244039
105ARAF0.55648875
106CHEK20.54994343
107FYN0.54938550
108BCKDK0.54864262
109IKBKE0.54351398
110MAP3K70.53830754
111PAK10.51873497
112MAPKAPK20.50695822
113MST40.50180581
114ILK0.49764312
115PIK3CG0.49730384
116HIPK20.49697432
117TBK10.48867186
118RPS6KC10.48220717
119RPS6KL10.48220717
120RPS6KA60.47863165
121PRKG20.47612541
122MAP2K20.47344184
123CDC42BPA0.46993952
124BRSK10.46359458
125KIT0.46182097
126RET0.45740732
127CAMKK20.45720311
128IRAK20.44379275
129ICK0.43780406
130IKBKB0.43386239
131PTK2B0.42908383
132CHEK10.42177698
133YES10.41938125
134MOS0.41906603
135PLK40.41795977
136TNK20.40378003
137IRAK10.39644420
138MAPK70.39348587
139NEK10.37548689
140MATK0.37420357
141CDK90.36574944
142CSNK2A20.36467854
143DYRK1B0.36285353
144CDK80.36091895
145RPS6KA50.36085463
146CDK20.35416591
147CSNK2A10.34950752
148FGFR30.34485535
149MAP3K50.33570062

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92797409
2Ribosome_Homo sapiens_hsa030104.01042137
3Mismatch repair_Homo sapiens_hsa034303.84437680
4Base excision repair_Homo sapiens_hsa034103.12393781
5Primary immunodeficiency_Homo sapiens_hsa053402.96644511
6Spliceosome_Homo sapiens_hsa030402.79897961
7Homologous recombination_Homo sapiens_hsa034402.73175652
8Allograft rejection_Homo sapiens_hsa053302.44207732
9Nucleotide excision repair_Homo sapiens_hsa034202.42477633
10Autoimmune thyroid disease_Homo sapiens_hsa053202.33618518
11* Cell cycle_Homo sapiens_hsa041102.22910555
12Proteasome_Homo sapiens_hsa030502.07218427
13One carbon pool by folate_Homo sapiens_hsa006702.00964535
14Pyrimidine metabolism_Homo sapiens_hsa002401.99583579
15RNA transport_Homo sapiens_hsa030131.95866573
16RNA polymerase_Homo sapiens_hsa030201.86940653
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86013714
18Non-homologous end-joining_Homo sapiens_hsa034501.78837089
19Staphylococcus aureus infection_Homo sapiens_hsa051501.78788629
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69910347
21Type I diabetes mellitus_Homo sapiens_hsa049401.68594162
22Tuberculosis_Homo sapiens_hsa051521.67204809
23Fanconi anemia pathway_Homo sapiens_hsa034601.65247250
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61304189
25* p53 signaling pathway_Homo sapiens_hsa041151.57931043
26Chemokine signaling pathway_Homo sapiens_hsa040621.48772441
27Asthma_Homo sapiens_hsa053101.46588870
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22273391
29B cell receptor signaling pathway_Homo sapiens_hsa046621.22229151
30Antigen processing and presentation_Homo sapiens_hsa046121.21856183
31Sulfur relay system_Homo sapiens_hsa041221.20256856
32Hematopoietic cell lineage_Homo sapiens_hsa046401.15139960
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14883066
34RNA degradation_Homo sapiens_hsa030181.14479424
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.12572411
36Herpes simplex infection_Homo sapiens_hsa051681.12107593
37Acute myeloid leukemia_Homo sapiens_hsa052211.11476357
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11103291
39Basal transcription factors_Homo sapiens_hsa030221.09826741
40TNF signaling pathway_Homo sapiens_hsa046681.09480684
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08183456
42mRNA surveillance pathway_Homo sapiens_hsa030151.07962017
43Epstein-Barr virus infection_Homo sapiens_hsa051691.06466174
44Thyroid cancer_Homo sapiens_hsa052161.02796462
45* Measles_Homo sapiens_hsa051621.02185242
46Purine metabolism_Homo sapiens_hsa002301.01897942
47Phagosome_Homo sapiens_hsa041451.01328726
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01076290
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00964182
50* HTLV-I infection_Homo sapiens_hsa051661.00846348
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98182950
52Pentose phosphate pathway_Homo sapiens_hsa000300.96958772
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96452930
54Small cell lung cancer_Homo sapiens_hsa052220.96332783
55Chronic myeloid leukemia_Homo sapiens_hsa052200.96130106
56Systemic lupus erythematosus_Homo sapiens_hsa053220.95895115
57Leishmaniasis_Homo sapiens_hsa051400.94365606
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93496097
59* Viral carcinogenesis_Homo sapiens_hsa052030.91370813
60Hepatitis C_Homo sapiens_hsa051600.91192235
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.91086248
62Endocytosis_Homo sapiens_hsa041440.89580789
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87497522
64Salmonella infection_Homo sapiens_hsa051320.87251033
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85316976
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.85235707
67Rheumatoid arthritis_Homo sapiens_hsa053230.84446854
68Hepatitis B_Homo sapiens_hsa051610.83748934
69Apoptosis_Homo sapiens_hsa042100.82841965
70Shigellosis_Homo sapiens_hsa051310.82839271
71African trypanosomiasis_Homo sapiens_hsa051430.77822677
72Pertussis_Homo sapiens_hsa051330.77498069
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76711462
74Renal cell carcinoma_Homo sapiens_hsa052110.76394022
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75363020
76Bladder cancer_Homo sapiens_hsa052190.74378139
77Endometrial cancer_Homo sapiens_hsa052130.74108050
78Prolactin signaling pathway_Homo sapiens_hsa049170.73031050
79Notch signaling pathway_Homo sapiens_hsa043300.72358868
80Other glycan degradation_Homo sapiens_hsa005110.72084908
81Folate biosynthesis_Homo sapiens_hsa007900.71672182
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71627247
83T cell receptor signaling pathway_Homo sapiens_hsa046600.71586950
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71440241
85Colorectal cancer_Homo sapiens_hsa052100.70798811
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.69731847
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.67537179
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.66451475
89MicroRNAs in cancer_Homo sapiens_hsa052060.65521194
90* Jak-STAT signaling pathway_Homo sapiens_hsa046300.63271221
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62430722
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62229996
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60846506
94Platelet activation_Homo sapiens_hsa046110.60728989
95N-Glycan biosynthesis_Homo sapiens_hsa005100.60147655
96Non-small cell lung cancer_Homo sapiens_hsa052230.59504144
97Choline metabolism in cancer_Homo sapiens_hsa052310.57574765
98Viral myocarditis_Homo sapiens_hsa054160.57353792
99Lysosome_Homo sapiens_hsa041420.55524283
100Inositol phosphate metabolism_Homo sapiens_hsa005620.55380605
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53458887
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53346238
103Osteoclast differentiation_Homo sapiens_hsa043800.53176324
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.53044606
105Glioma_Homo sapiens_hsa052140.52808553
106mTOR signaling pathway_Homo sapiens_hsa041500.51253140
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.50313649
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50123257
109Pancreatic cancer_Homo sapiens_hsa052120.49063570
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48975152
111Pathways in cancer_Homo sapiens_hsa052000.47698541
112Toxoplasmosis_Homo sapiens_hsa051450.47467556
113Malaria_Homo sapiens_hsa051440.47180555
114FoxO signaling pathway_Homo sapiens_hsa040680.46725543
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46260527
116Prostate cancer_Homo sapiens_hsa052150.45798767
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45308893
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45021901
119Legionellosis_Homo sapiens_hsa051340.45000591
120Protein export_Homo sapiens_hsa030600.42058503
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.41416979
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41034477
123HIF-1 signaling pathway_Homo sapiens_hsa040660.40600238
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38750618
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.38692238
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38352858
127GnRH signaling pathway_Homo sapiens_hsa049120.37439557
128Amoebiasis_Homo sapiens_hsa051460.36703922
129Insulin resistance_Homo sapiens_hsa049310.35412398
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35012596
131MAPK signaling pathway_Homo sapiens_hsa040100.34898193
132Influenza A_Homo sapiens_hsa051640.34163983
133VEGF signaling pathway_Homo sapiens_hsa043700.34157517
134Basal cell carcinoma_Homo sapiens_hsa052170.32124497
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.31786743
136Biosynthesis of amino acids_Homo sapiens_hsa012300.27505596
137Glutathione metabolism_Homo sapiens_hsa004800.26116840
138Selenocompound metabolism_Homo sapiens_hsa004500.25974371
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23712783
140Arachidonic acid metabolism_Homo sapiens_hsa005900.23680090
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23182994
142Graft-versus-host disease_Homo sapiens_hsa053320.22795022
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.22636619
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22150955
145Alcoholism_Homo sapiens_hsa050340.21592987

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