CCNE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.37808214
2regulation of retinoic acid receptor signaling pathway (GO:0048385)7.07553845
3mitotic metaphase plate congression (GO:0007080)5.04402309
4purine nucleobase biosynthetic process (GO:0009113)4.99090560
5nucleobase biosynthetic process (GO:0046112)4.92927335
6DNA replication checkpoint (GO:0000076)4.82805082
7ribosome assembly (GO:0042255)4.73559575
8DNA strand elongation involved in DNA replication (GO:0006271)4.57468465
9* DNA replication initiation (GO:0006270)4.56290572
10ribosome biogenesis (GO:0042254)4.39389313
11formation of translation preinitiation complex (GO:0001731)4.34463460
12DNA strand elongation (GO:0022616)4.34097466
13DNA deamination (GO:0045006)4.29698405
14protein localization to kinetochore (GO:0034501)4.26353743
15telomere maintenance via semi-conservative replication (GO:0032201)4.22826726
16DNA replication-dependent nucleosome assembly (GO:0006335)4.17172461
17DNA replication-dependent nucleosome organization (GO:0034723)4.17172461
18DNA unwinding involved in DNA replication (GO:0006268)4.10765468
19metaphase plate congression (GO:0051310)4.10122781
20mitotic nuclear envelope disassembly (GO:0007077)4.08181233
21* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.04846464
22regulation of spindle organization (GO:0090224)3.98439370
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.92296965
24folic acid-containing compound biosynthetic process (GO:0009396)3.91958486
25IMP biosynthetic process (GO:0006188)3.88117621
26maturation of SSU-rRNA (GO:0030490)3.85383745
27protein localization to chromosome, centromeric region (GO:0071459)3.79219008
28membrane disassembly (GO:0030397)3.78584365
29nuclear envelope disassembly (GO:0051081)3.78584365
30nuclear pore organization (GO:0006999)3.77541741
31telomere maintenance via recombination (GO:0000722)3.74730005
32ribonucleoprotein complex biogenesis (GO:0022613)3.71730069
33establishment of integrated proviral latency (GO:0075713)3.71566302
34mitotic sister chromatid segregation (GO:0000070)3.71490536
35positive regulation of chromosome segregation (GO:0051984)3.70010263
36chromatin remodeling at centromere (GO:0031055)3.66784469
37spliceosomal snRNP assembly (GO:0000387)3.66550397
38CENP-A containing nucleosome assembly (GO:0034080)3.65511002
39folic acid metabolic process (GO:0046655)3.65193339
40mitotic recombination (GO:0006312)3.53284790
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.50410275
42rRNA processing (GO:0006364)3.49994397
43rRNA modification (GO:0000154)3.48893531
44DNA replication-independent nucleosome assembly (GO:0006336)3.48096653
45DNA replication-independent nucleosome organization (GO:0034724)3.48096653
46pore complex assembly (GO:0046931)3.47748295
47telomere maintenance via telomere lengthening (GO:0010833)3.46182748
48regulation of posttranscriptional gene silencing (GO:0060147)3.45985968
49regulation of gene silencing by miRNA (GO:0060964)3.45985968
50regulation of gene silencing by RNA (GO:0060966)3.45985968
51ribosomal small subunit biogenesis (GO:0042274)3.45950893
52kinetochore assembly (GO:0051382)3.45373595
53mitotic sister chromatid cohesion (GO:0007064)3.44271138
54establishment of chromosome localization (GO:0051303)3.42958574
55somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42163575
56somatic hypermutation of immunoglobulin genes (GO:0016446)3.42163575
57kinetochore organization (GO:0051383)3.40922908
58heterochromatin organization (GO:0070828)3.40406549
59rRNA metabolic process (GO:0016072)3.39927311
60protein K6-linked ubiquitination (GO:0085020)3.36865537
61chromatin assembly or disassembly (GO:0006333)3.34811233
62regulation of translational fidelity (GO:0006450)3.34784490
63regulation of mitotic spindle organization (GO:0060236)3.34154182
64nuclear pore complex assembly (GO:0051292)3.33161796
65ribosomal large subunit biogenesis (GO:0042273)3.32945510
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.32544175
67proteasome assembly (GO:0043248)3.29297736
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29277813
69negative regulation of chromosome segregation (GO:0051985)3.27137464
70maturation of 5.8S rRNA (GO:0000460)3.26457457
71IMP metabolic process (GO:0046040)3.26402132
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.23549581
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.23400652
74spindle checkpoint (GO:0031577)3.23377087
75regulation of centrosome cycle (GO:0046605)3.22450991
76regulation of chromosome segregation (GO:0051983)3.22418302
77attachment of spindle microtubules to kinetochore (GO:0008608)3.21221955
78transcription-coupled nucleotide-excision repair (GO:0006283)3.19536167
79pseudouridine synthesis (GO:0001522)3.19193865
80histone exchange (GO:0043486)3.18557320
81chromosome condensation (GO:0030261)3.18186444
82DNA topological change (GO:0006265)3.17423590
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16586892
84sister chromatid segregation (GO:0000819)3.15383298
85protein complex localization (GO:0031503)3.14254475
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13936038
87negative regulation of sister chromatid segregation (GO:0033046)3.13936038
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.13936038
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13936038
90mitotic spindle checkpoint (GO:0071174)3.11597680
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.11038521
92termination of RNA polymerase III transcription (GO:0006386)3.11038521
93regulation of helicase activity (GO:0051095)3.10048156
94negative regulation of mRNA processing (GO:0050686)3.09679009
95transcription from mitochondrial promoter (GO:0006390)3.08856228
96regulation of histone H3-K9 methylation (GO:0051570)3.07783479
97regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05410182
98mitotic spindle assembly checkpoint (GO:0007094)3.04876725
99chromosome segregation (GO:0007059)3.04401684
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04122881
101spindle assembly checkpoint (GO:0071173)3.03741723
102mitotic chromosome condensation (GO:0007076)3.02182755
103nuclear envelope organization (GO:0006998)3.01963368
104* G1/S transition of mitotic cell cycle (GO:0000082)3.01864195
105* cell cycle G1/S phase transition (GO:0044843)3.01864195
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00888417
107chromatin assembly (GO:0031497)2.99724852
108regulation of translational termination (GO:0006449)2.98546705
109histone arginine methylation (GO:0034969)2.98231273
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98021058
111translational initiation (GO:0006413)2.94625328
112negative regulation of RNA splicing (GO:0033119)2.94468188
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94145492
114protein localization to chromosome (GO:0034502)2.93158024
115negative regulation of mRNA metabolic process (GO:1903312)2.92602768
116establishment of protein localization to mitochondrial membrane (GO:0090151)2.91504903
117DNA duplex unwinding (GO:0032508)2.91004035
118DNA geometric change (GO:0032392)2.90163892
119replication fork processing (GO:0031297)2.89956492
120spliceosomal complex assembly (GO:0000245)2.89447260
121regulation of RNA export from nucleus (GO:0046831)2.87258610
122regulation of mitochondrial translation (GO:0070129)2.86450192
123ATP-dependent chromatin remodeling (GO:0043044)2.86057727
124ribosomal small subunit assembly (GO:0000028)2.85815283
125termination of RNA polymerase II transcription (GO:0006369)2.84904235
126DNA synthesis involved in DNA repair (GO:0000731)2.83481318
127cellular protein complex localization (GO:0034629)2.83132616
128viral mRNA export from host cell nucleus (GO:0046784)2.82082629
129deoxyribonucleotide biosynthetic process (GO:0009263)2.80966560
130translesion synthesis (GO:0019985)2.80098486
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77967277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.28383148
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.37809161
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.09423206
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53190937
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47991946
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24345482
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05083644
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95396451
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94339964
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90691129
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79991656
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.79268051
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.71480922
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.59937638
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59791707
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47084848
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42728358
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33797892
19XRN2_22483619_ChIP-Seq_HELA_Human2.25755149
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24805724
21AR_21909140_ChIP-Seq_LNCAP_Human2.17110818
22* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.14730907
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10901168
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05822206
25VDR_23849224_ChIP-Seq_CD4+_Human2.05669113
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01243209
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00873477
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99846366
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.95652657
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.95603126
31* E2F1_21310950_ChIP-Seq_MCF-7_Human1.87980031
32DCP1A_22483619_ChIP-Seq_HELA_Human1.86178804
33GABP_19822575_ChIP-Seq_HepG2_Human1.84353510
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82642758
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78826030
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71641204
37FOXP3_21729870_ChIP-Seq_TREG_Human1.70988821
38TTF2_22483619_ChIP-Seq_HELA_Human1.70496868
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61550724
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61324348
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61324348
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61324348
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.58843605
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58062834
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57814790
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.57379815
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56375737
48* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54236255
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50226572
50KDM5A_27292631_Chip-Seq_BREAST_Human1.48217373
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48132641
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44600674
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42907918
54* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40909084
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39918543
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38939622
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38006133
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37028584
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34467518
60MYC_22102868_ChIP-Seq_BL_Human1.32477295
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30033254
62ELK1_19687146_ChIP-ChIP_HELA_Human1.29577721
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28429499
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27135918
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26504991
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.26261814
67CIITA_25753668_ChIP-Seq_RAJI_Human1.24778314
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24048702
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23036141
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19282254
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18622899
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16587276
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.15675445
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14656462
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.14337373
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10657368
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.09277533
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09243425
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07924267
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07872753
81TFEB_21752829_ChIP-Seq_HELA_Human1.07593131
82* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06729766
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05478704
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05413532
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04988075
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04774548
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02051324
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01661503
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01423172
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01189153
91* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01026545
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00713881
93ZNF263_19887448_ChIP-Seq_K562_Human0.99721045
94* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98402534
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.98099719
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97145562
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96609381
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96304006
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96214966
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94891465
101POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92540381
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91742596
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91474686
104SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90039784
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89567999
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.89528956
107* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89495712
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88156100
109MYC_18940864_ChIP-ChIP_HL60_Human0.86581490
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82346787
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82073958
112CHD1_26751641_Chip-Seq_LNCaP_Human0.81322666
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81140118
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80718420
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.78907490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.88647623
2MP0003111_abnormal_nucleus_morphology4.98841190
3MP0004957_abnormal_blastocyst_morpholog4.71795677
4* MP0010094_abnormal_chromosome_stability4.56549180
5MP0008057_abnormal_DNA_replication4.51165566
6MP0003077_abnormal_cell_cycle4.21494679
7MP0008058_abnormal_DNA_repair3.47141199
8MP0003123_paternal_imprinting3.04518170
9MP0008932_abnormal_embryonic_tissue2.84676843
10MP0008007_abnormal_cellular_replicative2.67816893
11MP0001730_embryonic_growth_arrest2.66298860
12MP0003718_maternal_effect2.57580546
13* MP0000350_abnormal_cell_proliferation2.40452040
14MP0008877_abnormal_DNA_methylation2.19153240
15MP0003786_premature_aging2.18424150
16MP0010352_gastrointestinal_tract_polyps2.07562700
17* MP0001672_abnormal_embryogenesis/_devel2.05741722
18* MP0005380_embryogenesis_phenotype2.05741722
19* MP0001697_abnormal_embryo_size1.94503813
20MP0002085_abnormal_embryonic_tissue1.85869996
21MP0004185_abnormal_adipocyte_glucose1.83738891
22* MP0002080_prenatal_lethality1.78586444
23* MP0003984_embryonic_growth_retardation1.75149757
24MP0002084_abnormal_developmental_patter1.71167391
25* MP0002088_abnormal_embryonic_growth/wei1.70746460
26MP0002653_abnormal_ependyma_morphology1.67502202
27MP0003806_abnormal_nucleotide_metabolis1.64664308
28* MP0002086_abnormal_extraembryonic_tissu1.61117753
29MP0010030_abnormal_orbit_morphology1.60143253
30MP0003567_abnormal_fetal_cardiomyocyte1.58026017
31MP0004197_abnormal_fetal_growth/weight/1.52906594
32MP0000490_abnormal_crypts_of1.52207163
33MP0002796_impaired_skin_barrier1.47018682
34MP0009697_abnormal_copulation1.45246703
35MP0000313_abnormal_cell_death1.44532864
36MP0006292_abnormal_olfactory_placode1.42853920
37MP0001293_anophthalmia1.41793606
38MP0003119_abnormal_digestive_system1.40304701
39* MP0010307_abnormal_tumor_latency1.40071676
40MP0003941_abnormal_skin_development1.37456822
41MP0003890_abnormal_embryonic-extraembry1.35577261
42MP0002396_abnormal_hematopoietic_system1.33371289
43MP0006035_abnormal_mitochondrial_morpho1.33314257
44* MP0002210_abnormal_sex_determination1.32462785
45MP0002019_abnormal_tumor_incidence1.31774819
46MP0003136_yellow_coat_color1.26438986
47MP0005076_abnormal_cell_differentiation1.24451197
48MP0004133_heterotaxia1.24290474
49MP0001346_abnormal_lacrimal_gland1.22383511
50* MP0001145_abnormal_male_reproductive1.22096032
51MP0003315_abnormal_perineum_morphology1.18006098
52MP0003121_genomic_imprinting1.16186772
53MP0001545_abnormal_hematopoietic_system1.15145487
54MP0005397_hematopoietic_system_phenotyp1.15145487
55MP0009379_abnormal_foot_pigmentation1.14848275
56MP0004233_abnormal_muscle_weight1.14803471
57MP0002697_abnormal_eye_size1.11591487
58MP0001929_abnormal_gametogenesis1.04989453
59MP0005394_taste/olfaction_phenotype1.01990140
60MP0005499_abnormal_olfactory_system1.01990140
61* MP0000653_abnormal_sex_gland1.01487241
62MP0002098_abnormal_vibrissa_morphology0.99021836
63MP0002877_abnormal_melanocyte_morpholog0.98567461
64MP0005451_abnormal_body_composition0.97542325
65MP0000003_abnormal_adipose_tissue0.96399593
66MP0002111_abnormal_tail_morphology0.95472686
67MP0003937_abnormal_limbs/digits/tail_de0.92726844
68MP0008260_abnormal_autophagy0.91294204
69MP0003221_abnormal_cardiomyocyte_apopto0.90746948
70MP0009053_abnormal_anal_canal0.90689443
71MP0002132_abnormal_respiratory_system0.87964780
72MP0009672_abnormal_birth_weight0.86288693
73MP0004147_increased_porphyrin_level0.85880978
74* MP0009333_abnormal_splenocyte_physiolog0.83411742
75MP0001119_abnormal_female_reproductive0.82079971
76MP0003186_abnormal_redox_activity0.80305045
77* MP0005384_cellular_phenotype0.80026279
78MP0004808_abnormal_hematopoietic_stem0.78548128
79MP0005377_hearing/vestibular/ear_phenot0.78065909
80MP0003878_abnormal_ear_physiology0.78065909
81MP0000537_abnormal_urethra_morphology0.77733169
82MP0000647_abnormal_sebaceous_gland0.77492558
83MP0008995_early_reproductive_senescence0.77457633
84MP0002163_abnormal_gland_morphology0.77444796
85* MP0001881_abnormal_mammary_gland0.76745354
86MP0003656_abnormal_erythrocyte_physiolo0.76698739
87* MP0005621_abnormal_cell_physiology0.76318466
88* MP0000358_abnormal_cell_content/0.75807753
89MP0009278_abnormal_bone_marrow0.75667840
90MP0010234_abnormal_vibrissa_follicle0.75175390
91MP0005395_other_phenotype0.74832588
92MP0000750_abnormal_muscle_regeneration0.74430168
93* MP0002160_abnormal_reproductive_system0.74149666
94MP0002254_reproductive_system_inflammat0.72961760
95MP0000428_abnormal_craniofacial_morphol0.72514360
96MP0003943_abnormal_hepatobiliary_system0.72494059
97MP0006036_abnormal_mitochondrial_physio0.72491488
98MP0009703_decreased_birth_body0.71622343
99MP0002092_abnormal_eye_morphology0.71024711
100MP0003566_abnormal_cell_adhesion0.70850435
101MP0004264_abnormal_extraembryonic_tissu0.70097587
102MP0001286_abnormal_eye_development0.69906148
103MP0000566_synostosis0.69592563
104MP0001661_extended_life_span0.68966608
105MP0002102_abnormal_ear_morphology0.68692833
106MP0000703_abnormal_thymus_morphology0.68541005
107* MP0005389_reproductive_system_phenotype0.67275763
108MP0001849_ear_inflammation0.66921179
109MP0000049_abnormal_middle_ear0.66701452
110MP0003705_abnormal_hypodermis_morpholog0.66589346
111MP0003699_abnormal_female_reproductive0.65579079
112MP0000762_abnormal_tongue_morphology0.65025416
113MP0002233_abnormal_nose_morphology0.64278978
114MP0002089_abnormal_postnatal_growth/wei0.63602832
115MP0000858_altered_metastatic_potential0.62975826
116MP0000432_abnormal_head_morphology0.62923918
117MP0001216_abnormal_epidermal_layer0.62081532
118MP0003938_abnormal_ear_development0.61731817
119MP0005266_abnormal_metabolism0.61322309
120MP0001919_abnormal_reproductive_system0.61311586
121MP0003861_abnormal_nervous_system0.60364393
122* MP0002722_abnormal_immune_system0.60060530
123MP0005023_abnormal_wound_healing0.59245418
124MP0001915_intracranial_hemorrhage0.59239667
125MP0008789_abnormal_olfactory_epithelium0.57939614
126* MP0002161_abnormal_fertility/fecundity0.57642841
127MP0008770_decreased_survivor_rate0.56150482
128* MP0000689_abnormal_spleen_morphology0.55939343
129MP0005501_abnormal_skin_physiology0.55853016
130MP0003755_abnormal_palate_morphology0.55671907
131MP0003935_abnormal_craniofacial_develop0.53974630

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.31199846
2Breast hypoplasia (HP:0003187)5.28171616
3Patellar aplasia (HP:0006443)4.14301779
4Aplasia/Hypoplasia of the patella (HP:0006498)3.93875225
5Impulsivity (HP:0100710)3.79930324
6Abnormality of the labia minora (HP:0012880)3.76545104
7Carpal bone hypoplasia (HP:0001498)3.65741241
8Absent radius (HP:0003974)3.64489343
9Ependymoma (HP:0002888)3.55457269
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54420590
11Selective tooth agenesis (HP:0001592)3.49664333
12Chromsome breakage (HP:0040012)3.46723211
13Cerebral hypomyelination (HP:0006808)3.45040004
14Absent forearm bone (HP:0003953)3.41068076
15Aplasia involving forearm bones (HP:0009822)3.41068076
16Meckel diverticulum (HP:0002245)3.34989237
17Rough bone trabeculation (HP:0100670)3.34876483
18Oral leukoplakia (HP:0002745)3.28937682
19Abnormality of the ileum (HP:0001549)3.27712359
20Supernumerary spleens (HP:0009799)3.23469711
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.19292346
22Microvesicular hepatic steatosis (HP:0001414)3.15778165
23Abnormality of the preputium (HP:0100587)3.12497767
24Absent thumb (HP:0009777)3.11764440
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.09110057
26Abnormality of the anterior horn cell (HP:0006802)3.06413196
27Degeneration of anterior horn cells (HP:0002398)3.06413196
28Abnormality of chromosome stability (HP:0003220)3.02038503
29Aplasia/Hypoplasia of the uvula (HP:0010293)3.01722807
30Reticulocytopenia (HP:0001896)3.00504374
31Medulloblastoma (HP:0002885)2.97147648
32Abnormality of cells of the erythroid lineage (HP:0012130)2.94455152
33Agnosia (HP:0010524)2.83951415
34Colon cancer (HP:0003003)2.78353920
35Abnormal number of erythroid precursors (HP:0012131)2.76918658
36Facial hemangioma (HP:0000329)2.75979492
37Premature ovarian failure (HP:0008209)2.68511418
38Rhabdomyosarcoma (HP:0002859)2.66662907
39Small intestinal stenosis (HP:0012848)2.59533374
40Duodenal stenosis (HP:0100867)2.59533374
41Facial cleft (HP:0002006)2.58795004
42Aplasia/hypoplasia of the humerus (HP:0006507)2.57501331
43Abnormality of the fetal cardiovascular system (HP:0010948)2.56586984
44Abnormal umbilical cord blood vessels (HP:0011403)2.56586984
45Single umbilical artery (HP:0001195)2.56586984
46Neoplasm of the pancreas (HP:0002894)2.55277335
47Trismus (HP:0000211)2.50360529
48Breast aplasia (HP:0100783)2.45846920
49Horseshoe kidney (HP:0000085)2.45242358
50Premature graying of hair (HP:0002216)2.44682082
51Abnormal trabecular bone morphology (HP:0100671)2.43726489
52Multiple enchondromatosis (HP:0005701)2.40260192
53Abnormal number of incisors (HP:0011064)2.39976714
54Microretrognathia (HP:0000308)2.36501556
55Secondary amenorrhea (HP:0000869)2.36244172
56Nephroblastoma (Wilms tumor) (HP:0002667)2.35846235
57Bone marrow hypocellularity (HP:0005528)2.34468447
58Myelodysplasia (HP:0002863)2.33753107
59Increased nuchal translucency (HP:0010880)2.32999994
60Macrocytic anemia (HP:0001972)2.29009612
61Progressive muscle weakness (HP:0003323)2.28650178
62Tracheoesophageal fistula (HP:0002575)2.28390554
63Rib fusion (HP:0000902)2.28237339
64Basal cell carcinoma (HP:0002671)2.27873503
65Aplasia/Hypoplasia of the breasts (HP:0010311)2.27645917
66Progressive external ophthalmoplegia (HP:0000590)2.27541618
67Atresia of the external auditory canal (HP:0000413)2.24427045
68Astrocytoma (HP:0009592)2.23927071
69Abnormality of the astrocytes (HP:0100707)2.23927071
70Glioma (HP:0009733)2.23611712
71Triphalangeal thumb (HP:0001199)2.19984235
72Abnormality of the duodenum (HP:0002246)2.19100185
73Short thumb (HP:0009778)2.18687049
74Embryonal renal neoplasm (HP:0011794)2.15617099
75Abnormality of cochlea (HP:0000375)2.15420181
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.14767574
77Sloping forehead (HP:0000340)2.13729408
78Duplication of thumb phalanx (HP:0009942)2.12748864
79Male infertility (HP:0003251)2.11985017
80Squamous cell carcinoma (HP:0002860)2.10749056
81Ectopic kidney (HP:0000086)2.10623598
82Cleft eyelid (HP:0000625)2.10395786
83Short humerus (HP:0005792)2.10183973
84Abnormality of abdominal situs (HP:0011620)2.10158421
85Abdominal situs inversus (HP:0003363)2.10158421
86Ureteral duplication (HP:0000073)2.08001377
87Choanal atresia (HP:0000453)2.06142979
88Sparse lateral eyebrow (HP:0005338)2.06041155
89Cafe-au-lait spot (HP:0000957)2.05449913
90Hypergonadotropic hypogonadism (HP:0000815)2.05378872
91CNS hypomyelination (HP:0003429)2.05338216
92Hypoplasia of the radius (HP:0002984)2.04262323
93Cellular immunodeficiency (HP:0005374)2.03490606
94Neoplasm of the oral cavity (HP:0100649)2.00754379
95Microglossia (HP:0000171)1.99989619
96Slender long bone (HP:0003100)1.99811147
97Hyperglycinemia (HP:0002154)1.99253412
98Deviation of the thumb (HP:0009603)1.98317160
99Prominent nose (HP:0000448)1.98129502
100Megaloblastic anemia (HP:0001889)1.97458735
101Abnormality of glycolysis (HP:0004366)1.96149048
102Neoplasm of striated muscle (HP:0009728)1.95151454
103Aplastic anemia (HP:0001915)1.94752026
104Duplicated collecting system (HP:0000081)1.94687513
105Oligodactyly (HP:0012165)1.92232262
106Capillary hemangiomas (HP:0005306)1.90961135
107Pallor (HP:0000980)1.90874476
108Abnormality of reticulocytes (HP:0004312)1.89785981
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.89653483
110Short middle phalanx of the 5th finger (HP:0004220)1.88485799
111Increased serum pyruvate (HP:0003542)1.88322986
112Rectal fistula (HP:0100590)1.87948760
113Rectovaginal fistula (HP:0000143)1.87948760
114Abnormal lung lobation (HP:0002101)1.86240471
115Spinal muscular atrophy (HP:0007269)1.85779515
116Abnormality of the umbilical cord (HP:0010881)1.84758306
117Personality changes (HP:0000751)1.84560823
118Abnormality of the carotid arteries (HP:0005344)1.83591263
119Pancreatic islet-cell hyperplasia (HP:0004510)1.83558677
120Proximal placement of thumb (HP:0009623)1.83141752
121Dysphonia (HP:0001618)1.82564011
122Pancytopenia (HP:0001876)1.82267956
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.80624556
124Clubbing of toes (HP:0100760)1.79090063
125Abnormalities of placenta or umbilical cord (HP:0001194)1.77673642
126Sparse eyelashes (HP:0000653)1.77079372
127Shawl scrotum (HP:0000049)1.75793592
128Abnormality of the septum pellucidum (HP:0007375)1.74133151
129Cholecystitis (HP:0001082)1.73785360
130Abnormal gallbladder physiology (HP:0012438)1.73785360
131Hypoplasia of the pons (HP:0012110)1.73020986
132Abnormality of DNA repair (HP:0003254)1.71696322
133Abnormality of pyrimidine metabolism (HP:0004353)1.70854728
134Type I transferrin isoform profile (HP:0003642)1.67816340
135Septate vagina (HP:0001153)1.66685989
136Arteriovenous malformation (HP:0100026)1.66313386
137Poikiloderma (HP:0001029)1.66027477
138Absent septum pellucidum (HP:0001331)1.65793550
139Abnormality of the pons (HP:0007361)1.63962254
140Reduced antithrombin III activity (HP:0001976)1.63255605
141Nonimmune hydrops fetalis (HP:0001790)1.62208228
142Ankle contracture (HP:0006466)1.61270508
143Abnormality of methionine metabolism (HP:0010901)1.60876209
144Abnormality of the renal collecting system (HP:0004742)1.60368548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.59372459
2WEE15.03352615
3CDC73.56160627
4EIF2AK13.07164507
5NEK22.91776893
6PLK42.66226220
7TTK2.56066138
8TSSK62.54917377
9SRPK12.45934781
10VRK22.37578226
11SMG12.34682067
12EPHA22.34134971
13NEK12.30213980
14PLK12.25412919
15ACVR1B2.10997080
16NME22.09416332
17DYRK32.03166168
18BRSK21.98890615
19CDK71.87256721
20MKNK21.82011874
21PLK31.73752567
22CHEK21.67805424
23TESK21.65990321
24LATS21.65499151
25MKNK11.65092402
26EIF2AK31.64838781
27AURKB1.63777502
28TLK11.53480854
29VRK11.53174836
30AURKA1.51754271
31STK161.51687006
32MST41.44602260
33ATR1.44242265
34RPS6KB21.43185615
35AKT31.41971114
36CDK121.40473808
37MAP3K81.33857688
38TAF11.33685389
39CDK41.33551034
40BRSK11.33523151
41RPS6KA41.29820105
42TRIB31.28496140
43PNCK1.27750008
44CHEK11.21222046
45ZAK1.18277830
46STK38L1.05372458
47MAP3K91.04739403
48STK101.00430738
49PIM10.99178667
50BRAF0.95734821
51ALK0.94586427
52MAP3K110.90891849
53* CDK20.87623643
54CDK190.87313365
55STK40.85705001
56PASK0.85616483
57SCYL20.85229643
58CCNB10.84188932
59PAK40.81595776
60ATM0.81029652
61PIM20.80186929
62PRKCI0.79171570
63PAK10.78720441
64CDK90.76808802
65STK30.75607893
66DYRK20.72219282
67STK240.71203815
68BMX0.70938429
69CSNK2A20.69557401
70CSNK2A10.66888817
71CDK10.63417063
72MAPKAPK30.62479611
73CDK60.60452660
74MELK0.57464918
75EIF2AK20.53214480
76TRIM280.51928174
77PRPF4B0.49619749
78CLK10.49333656
79CSNK1E0.48476121
80RAF10.44032282
81CDK11A0.43580931
82AKT20.43255162
83MTOR0.42945310
84BRD40.41947781
85TAOK20.41713934
86LRRK20.40317588
87RPS6KA50.40100806
88NUAK10.37385987
89PDK30.36928540
90PDK40.36928540
91CDK80.36822744
92NEK60.36527019
93FLT30.36479084
94EEF2K0.36082652
95LATS10.35471903
96KDR0.35371385
97PDK20.35108313
98ILK0.34834916
99CDK150.33127192
100MET0.32942129
101CDK180.30800550
102PAK20.29849654
103ABL20.28297857
104MAP3K50.28012246
105MARK30.27989370
106PRKDC0.27818035
107MAP3K60.27744129
108TGFBR10.26798064
109ARAF0.26600252
110PTK20.26411848
111PBK0.25905680
112DAPK10.25220769
113MAPK110.24117188
114MAP3K100.23942841
115ICK0.23921747
116NME10.23890786
117CSNK1D0.22453845
118ERBB40.21807025
119YES10.20534868
120DDR20.20406586
121* MAPK140.18779795
122IRAK30.17453224
123TESK10.16423547

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82995043
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28014326
3Mismatch repair_Homo sapiens_hsa034304.27986851
4RNA polymerase_Homo sapiens_hsa030203.73842203
5RNA transport_Homo sapiens_hsa030133.47123679
6Spliceosome_Homo sapiens_hsa030403.33999655
7Proteasome_Homo sapiens_hsa030503.06828259
8Base excision repair_Homo sapiens_hsa034102.97734784
9Nucleotide excision repair_Homo sapiens_hsa034202.91284908
10* Cell cycle_Homo sapiens_hsa041102.88126079
11Homologous recombination_Homo sapiens_hsa034402.87663494
12Ribosome_Homo sapiens_hsa030102.81912261
13One carbon pool by folate_Homo sapiens_hsa006702.64062368
14Pyrimidine metabolism_Homo sapiens_hsa002402.57064539
15Vitamin B6 metabolism_Homo sapiens_hsa007502.42748740
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36475880
17Fanconi anemia pathway_Homo sapiens_hsa034602.34858530
18Basal transcription factors_Homo sapiens_hsa030222.06095875
19* p53 signaling pathway_Homo sapiens_hsa041151.80645079
20mRNA surveillance pathway_Homo sapiens_hsa030151.79407290
21RNA degradation_Homo sapiens_hsa030181.72555747
22Non-homologous end-joining_Homo sapiens_hsa034501.54748884
23Folate biosynthesis_Homo sapiens_hsa007901.50070996
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43562247
25Purine metabolism_Homo sapiens_hsa002301.41081898
26Epstein-Barr virus infection_Homo sapiens_hsa051691.20939431
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.20814478
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18636649
29Biosynthesis of amino acids_Homo sapiens_hsa012301.17663646
30* Oocyte meiosis_Homo sapiens_hsa041141.12164270
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10619432
32Protein export_Homo sapiens_hsa030601.06261188
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05872503
34Pentose phosphate pathway_Homo sapiens_hsa000301.04062408
35Sulfur relay system_Homo sapiens_hsa041221.04013586
36Fatty acid elongation_Homo sapiens_hsa000621.01516471
37N-Glycan biosynthesis_Homo sapiens_hsa005100.97000725
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96381117
39Systemic lupus erythematosus_Homo sapiens_hsa053220.96079650
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94586736
41Pyruvate metabolism_Homo sapiens_hsa006200.87360915
42Parkinsons disease_Homo sapiens_hsa050120.85242761
43Steroid biosynthesis_Homo sapiens_hsa001000.83811286
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.82016940
45Selenocompound metabolism_Homo sapiens_hsa004500.81604520
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81570363
47* Viral carcinogenesis_Homo sapiens_hsa052030.79875734
48Herpes simplex infection_Homo sapiens_hsa051680.75560252
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68639603
50Oxidative phosphorylation_Homo sapiens_hsa001900.68016528
51Glutathione metabolism_Homo sapiens_hsa004800.64524471
52Thyroid cancer_Homo sapiens_hsa052160.62116993
53Hippo signaling pathway_Homo sapiens_hsa043900.60165180
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.59981295
55Antigen processing and presentation_Homo sapiens_hsa046120.59623869
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59033005
57HTLV-I infection_Homo sapiens_hsa051660.57661218
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56016760
59Fructose and mannose metabolism_Homo sapiens_hsa000510.54093552
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53254249
61* MicroRNAs in cancer_Homo sapiens_hsa052060.50775362
62Carbon metabolism_Homo sapiens_hsa012000.49525772
63TGF-beta signaling pathway_Homo sapiens_hsa043500.47892299
64Regulation of autophagy_Homo sapiens_hsa041400.46512215
65Bladder cancer_Homo sapiens_hsa052190.44614601
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43828127
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42924281
68Basal cell carcinoma_Homo sapiens_hsa052170.42461224
69Lysine degradation_Homo sapiens_hsa003100.40696159
70Hedgehog signaling pathway_Homo sapiens_hsa043400.37911901
71Huntingtons disease_Homo sapiens_hsa050160.37425965
72mTOR signaling pathway_Homo sapiens_hsa041500.36911271
73Arginine and proline metabolism_Homo sapiens_hsa003300.34763361
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32856631
75* Small cell lung cancer_Homo sapiens_hsa052220.32780571
76Apoptosis_Homo sapiens_hsa042100.31358041
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30746394
78Legionellosis_Homo sapiens_hsa051340.29954558
79Colorectal cancer_Homo sapiens_hsa052100.29909976
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27988452
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27150947
82Alcoholism_Homo sapiens_hsa050340.26878294
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26715847
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.25762443
85HIF-1 signaling pathway_Homo sapiens_hsa040660.25574905
86Metabolic pathways_Homo sapiens_hsa011000.25137244
87Notch signaling pathway_Homo sapiens_hsa043300.24552025
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23878623
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22502848
90Alzheimers disease_Homo sapiens_hsa050100.21696238
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.20984935
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18601716
93Arginine biosynthesis_Homo sapiens_hsa002200.18341823
94Vitamin digestion and absorption_Homo sapiens_hsa049770.18321747
95Galactose metabolism_Homo sapiens_hsa000520.17355899
96Pancreatic cancer_Homo sapiens_hsa052120.16576055
97Tight junction_Homo sapiens_hsa045300.15615539
98Propanoate metabolism_Homo sapiens_hsa006400.15441785
99Adherens junction_Homo sapiens_hsa045200.15274179
100Wnt signaling pathway_Homo sapiens_hsa043100.14326271
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14030881
102* Pathways in cancer_Homo sapiens_hsa052000.13107465
103Sulfur metabolism_Homo sapiens_hsa009200.12493397
104Ovarian steroidogenesis_Homo sapiens_hsa049130.12424750
105Shigellosis_Homo sapiens_hsa051310.12150425
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11710661
107FoxO signaling pathway_Homo sapiens_hsa040680.11371296
108Melanoma_Homo sapiens_hsa052180.10575106
109* Hepatitis B_Homo sapiens_hsa051610.10122874
110Circadian rhythm_Homo sapiens_hsa047100.09961296
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.08556566
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07973772
113Arachidonic acid metabolism_Homo sapiens_hsa005900.07026973
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05962244
115Linoleic acid metabolism_Homo sapiens_hsa005910.03423881
116* Prostate cancer_Homo sapiens_hsa052150.02904218
117Acute myeloid leukemia_Homo sapiens_hsa052210.02309519
118Chronic myeloid leukemia_Homo sapiens_hsa052200.01263738
119Influenza A_Homo sapiens_hsa051640.00543040
120Renin-angiotensin system_Homo sapiens_hsa04614-0.0082271

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