CCNE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)6.31127974
2DNA unwinding involved in DNA replication (GO:0006268)6.16544855
3telomere maintenance via semi-conservative replication (GO:0032201)6.11407394
4DNA strand elongation (GO:0022616)5.96773290
5* DNA replication initiation (GO:0006270)5.86994075
6DNA replication checkpoint (GO:0000076)5.76282183
7telomere maintenance via recombination (GO:0000722)5.62336576
8mitotic recombination (GO:0006312)5.47619787
9CENP-A containing nucleosome assembly (GO:0034080)5.06890618
10chromatin remodeling at centromere (GO:0031055)5.00899213
11regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.91675470
12protein localization to kinetochore (GO:0034501)4.87405351
13DNA replication-dependent nucleosome organization (GO:0034723)4.86936163
14DNA replication-dependent nucleosome assembly (GO:0006335)4.86936163
15mitotic chromosome condensation (GO:0007076)4.77561021
16nucleotide-excision repair, DNA gap filling (GO:0006297)4.77491949
17kinetochore organization (GO:0051383)4.69920720
18proteasome assembly (GO:0043248)4.69236674
19DNA replication-independent nucleosome organization (GO:0034724)4.66096484
20DNA replication-independent nucleosome assembly (GO:0006336)4.66096484
21telomere maintenance via telomere lengthening (GO:0010833)4.61347582
22nuclear pore complex assembly (GO:0051292)4.30239544
23translesion synthesis (GO:0019985)4.27846758
24DNA catabolic process, exonucleolytic (GO:0000738)4.26280595
25mitotic metaphase plate congression (GO:0007080)4.21143978
26mitotic sister chromatid cohesion (GO:0007064)4.20995590
27protein localization to chromosome, centromeric region (GO:0071459)4.19800919
28histone exchange (GO:0043486)4.18992777
29nuclear pore organization (GO:0006999)4.18471868
30folic acid-containing compound biosynthetic process (GO:0009396)4.11157861
31DNA ligation (GO:0006266)4.09098652
32mitotic nuclear envelope disassembly (GO:0007077)4.05034575
33mitotic sister chromatid segregation (GO:0000070)4.04188841
34sister chromatid segregation (GO:0000819)4.02205414
35IMP biosynthetic process (GO:0006188)3.99636427
36regulation of double-strand break repair via homologous recombination (GO:0010569)3.97493943
37kinetochore assembly (GO:0051382)3.90958611
38attachment of spindle microtubules to kinetochore (GO:0008608)3.90517431
39postreplication repair (GO:0006301)3.86654721
40metaphase plate congression (GO:0051310)3.85261240
41nucleobase biosynthetic process (GO:0046112)3.82367509
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80055142
43nuclear envelope disassembly (GO:0051081)3.77750749
44membrane disassembly (GO:0030397)3.77750749
45establishment of integrated proviral latency (GO:0075713)3.76212569
46chromatin assembly or disassembly (GO:0006333)3.73657577
47deoxyribonucleotide biosynthetic process (GO:0009263)3.70483225
48meiotic chromosome segregation (GO:0045132)3.68247580
49establishment of chromosome localization (GO:0051303)3.67308940
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65265093
51telomere maintenance (GO:0000723)3.62680667
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.61464538
53telomere organization (GO:0032200)3.59275758
54purine nucleobase biosynthetic process (GO:0009113)3.57745823
55DNA duplex unwinding (GO:0032508)3.57150653
56DNA geometric change (GO:0032392)3.55953175
57IMP metabolic process (GO:0046040)3.55799178
58ribosome assembly (GO:0042255)3.54322032
59regulation of centrosome cycle (GO:0046605)3.49020712
60double-strand break repair via nonhomologous end joining (GO:0006303)3.48892251
61non-recombinational repair (GO:0000726)3.48892251
62regulation of centriole replication (GO:0046599)3.47607868
63DNA topological change (GO:0006265)3.47258590
64mismatch repair (GO:0006298)3.45872861
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.44761327
66microtubule depolymerization (GO:0007019)3.44534987
67chromosome segregation (GO:0007059)3.41944942
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39746894
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38829203
70recombinational repair (GO:0000725)3.37563697
71double-strand break repair via homologous recombination (GO:0000724)3.37055167
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34620761
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34189782
74regulation of DNA endoreduplication (GO:0032875)3.33894344
75chromosome condensation (GO:0030261)3.33179906
76DNA double-strand break processing (GO:0000729)3.32860626
77protein K6-linked ubiquitination (GO:0085020)3.32212934
78regulation of centrosome duplication (GO:0010824)3.31363256
79transcription-coupled nucleotide-excision repair (GO:0006283)3.29470863
80pore complex assembly (GO:0046931)3.29338374
81* G1/S transition of mitotic cell cycle (GO:0000082)3.29135818
82* cell cycle G1/S phase transition (GO:0044843)3.29135818
83* mitotic cell cycle (GO:0000278)3.26480063
84DNA conformation change (GO:0071103)3.26446170
85dosage compensation (GO:0007549)3.25738051
86DNA replication (GO:0006260)3.25252024
87ATP-dependent chromatin remodeling (GO:0043044)3.22673750
88spindle checkpoint (GO:0031577)3.18229587
89somatic hypermutation of immunoglobulin genes (GO:0016446)3.17592740
90somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17592740
91DNA synthesis involved in DNA repair (GO:0000731)3.17269693
92maturation of 5.8S rRNA (GO:0000460)3.16573005
93negative regulation of mRNA processing (GO:0050686)3.15979272
94base-excision repair (GO:0006284)3.15859239
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14754891
96negative regulation of ligase activity (GO:0051352)3.14754891
97protein localization to chromosome (GO:0034502)3.11695283
98regulation of chromosome segregation (GO:0051983)3.11361378
99regulation of mitotic spindle checkpoint (GO:1903504)3.10831393
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10831393
101regulation of sister chromatid cohesion (GO:0007063)3.09107521
102regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08603393
103regulation of spindle organization (GO:0090224)3.08093116
104DNA recombination (GO:0006310)3.07830989
105synapsis (GO:0007129)3.07830438
106DNA packaging (GO:0006323)3.07535639
107mitotic spindle checkpoint (GO:0071174)3.05856014
108regulation of double-strand break repair (GO:2000779)3.05602285
109positive regulation of chromosome segregation (GO:0051984)3.03349839
110regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02760140
111replication fork processing (GO:0031297)3.01597133
112formation of translation preinitiation complex (GO:0001731)3.00728012
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99949393
114negative regulation of sister chromatid segregation (GO:0033046)2.99949393
115negative regulation of mitotic sister chromatid separation (GO:2000816)2.99949393
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99949393
117regulation of nuclear cell cycle DNA replication (GO:0033262)2.98521695
118spindle assembly checkpoint (GO:0071173)2.98114196
119negative regulation of chromosome segregation (GO:0051985)2.98102490
120mitotic G2/M transition checkpoint (GO:0044818)2.97586831
121mitotic DNA integrity checkpoint (GO:0044774)2.94914487
122ribosomal small subunit assembly (GO:0000028)2.94640231
123intra-S DNA damage checkpoint (GO:0031573)2.93051833
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.92642066
125chromosome organization (GO:0051276)2.90834080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.93973827
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.78077023
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.70454678
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56106091
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39791228
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07431054
7* AR_21909140_ChIP-Seq_LNCAP_Human2.85807739
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.73349494
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.61893935
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51592438
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.40827957
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40283957
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40174854
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37147108
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33947905
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26072559
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.08337993
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07018652
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04933238
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03231036
21E2F7_22180533_ChIP-Seq_HELA_Human12.7954466
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99905884
23VDR_23849224_ChIP-Seq_CD4+_Human1.99585907
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97007713
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.96635010
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96015941
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94864326
28XRN2_22483619_ChIP-Seq_HELA_Human1.94348742
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90521964
30DCP1A_22483619_ChIP-Seq_HELA_Human1.90182461
31ELK1_19687146_ChIP-ChIP_HELA_Human1.85431311
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80591265
33FOXP3_21729870_ChIP-Seq_TREG_Human1.78055702
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72531892
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69772695
36TTF2_22483619_ChIP-Seq_HELA_Human1.67120055
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66042167
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62828305
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62542525
40* GABP_19822575_ChIP-Seq_HepG2_Human1.61277549
41* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57884397
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56809358
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51545254
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50144269
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41381090
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40805936
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38099900
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37801371
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36183458
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35019352
51MYC_22102868_ChIP-Seq_BL_Human1.32002219
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31422233
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30885470
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30398353
55KDM5A_27292631_Chip-Seq_BREAST_Human1.27441865
56CIITA_25753668_ChIP-Seq_RAJI_Human1.24703756
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.22740112
58IRF1_19129219_ChIP-ChIP_H3396_Human1.21870739
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21321798
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18791836
61EWS_26573619_Chip-Seq_HEK293_Human1.18407309
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16029155
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.13798197
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13573332
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12016871
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10158211
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.09799915
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09379363
69MYC_18940864_ChIP-ChIP_HL60_Human1.08666105
70VDR_22108803_ChIP-Seq_LS180_Human1.05330920
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04183025
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03142803
73* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02709933
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02463378
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01700078
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01032296
77FUS_26573619_Chip-Seq_HEK293_Human1.00126117
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97517981
79TFEB_21752829_ChIP-Seq_HELA_Human0.97279973
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94088610
81* NANOG_16153702_ChIP-ChIP_HESCs_Human0.93661695
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93577612
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93471745
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92717930
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90724943
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.89459772
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88694715
88SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87032781
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85995638
90IGF1R_20145208_ChIP-Seq_DFB_Human0.84315603
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83927151
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.83670172
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.82569939
94SPI1_23547873_ChIP-Seq_NB4_Human0.81765080
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79184769
96* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77527285
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77389104
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.76286473
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75787288
100VDR_21846776_ChIP-Seq_THP-1_Human0.74728144
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74705060
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74493263
103ZNF274_21170338_ChIP-Seq_K562_Hela0.72583541
104* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68599426
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.68046765
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.66674183
107MYB_21317192_ChIP-Seq_ERMYB_Mouse0.64974726
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.64466931
109* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64290812
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.64277028
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.63505981
112* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.62230458
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.60633531
114CHD1_26751641_Chip-Seq_LNCaP_Human0.59939060
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56252492
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.53294386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.61165527
2MP0003693_abnormal_embryo_hatching4.88272996
3MP0008057_abnormal_DNA_replication4.79492083
4MP0003111_abnormal_nucleus_morphology4.50629575
5MP0003077_abnormal_cell_cycle4.08915507
6MP0004957_abnormal_blastocyst_morpholog4.06689301
7MP0008058_abnormal_DNA_repair3.41412532
8MP0008007_abnormal_cellular_replicative3.01553102
9MP0003123_paternal_imprinting2.99401707
10MP0003806_abnormal_nucleotide_metabolis2.76371355
11MP0008932_abnormal_embryonic_tissue2.72863339
12MP0002396_abnormal_hematopoietic_system2.57721151
13MP0010307_abnormal_tumor_latency2.55171703
14MP0008877_abnormal_DNA_methylation2.55102317
15MP0000350_abnormal_cell_proliferation2.24337654
16MP0001730_embryonic_growth_arrest2.17617343
17MP0006054_spinal_hemorrhage2.16908335
18MP0003121_genomic_imprinting1.97437867
19MP0010352_gastrointestinal_tract_polyps1.91318495
20MP0000490_abnormal_crypts_of1.83922893
21MP0006292_abnormal_olfactory_placode1.71380726
22MP0004808_abnormal_hematopoietic_stem1.70920474
23MP0003786_premature_aging1.68302631
24MP0001697_abnormal_embryo_size1.66459367
25MP0001672_abnormal_embryogenesis/_devel1.65877596
26MP0005380_embryogenesis_phenotype1.65877596
27MP0003984_embryonic_growth_retardation1.51742532
28MP0002019_abnormal_tumor_incidence1.47547125
29MP0002088_abnormal_embryonic_growth/wei1.47109922
30MP0002080_prenatal_lethality1.45468479
31MP0000313_abnormal_cell_death1.40706871
32MP0004197_abnormal_fetal_growth/weight/1.40642170
33MP0005076_abnormal_cell_differentiation1.37816002
34MP0003890_abnormal_embryonic-extraembry1.37655888
35MP0003567_abnormal_fetal_cardiomyocyte1.33817704
36MP0002085_abnormal_embryonic_tissue1.33640572
37MP0001529_abnormal_vocalization1.32036101
38MP0006072_abnormal_retinal_apoptosis1.30489164
39* MP0002210_abnormal_sex_determination1.30115948
40MP0002086_abnormal_extraembryonic_tissu1.29524386
41MP0006035_abnormal_mitochondrial_morpho1.27271773
42MP0000372_irregular_coat_pigmentation1.26423238
43MP0003656_abnormal_erythrocyte_physiolo1.25316524
44MP0003315_abnormal_perineum_morphology1.24532668
45MP0009333_abnormal_splenocyte_physiolog1.24152145
46MP0004147_increased_porphyrin_level1.23469247
47MP0002084_abnormal_developmental_patter1.22704643
48MP0005397_hematopoietic_system_phenotyp1.17010276
49MP0001545_abnormal_hematopoietic_system1.17010276
50MP0003941_abnormal_skin_development1.16303720
51MP0008789_abnormal_olfactory_epithelium1.14693546
52MP0003718_maternal_effect1.13623755
53MP0000703_abnormal_thymus_morphology1.13451696
54MP0002398_abnormal_bone_marrow1.12299026
55MP0005171_absent_coat_pigmentation1.12207792
56MP0009697_abnormal_copulation1.11938140
57MP0003763_abnormal_thymus_physiology1.10793469
58MP0002751_abnormal_autonomic_nervous1.10221100
59* MP0001145_abnormal_male_reproductive1.09770623
60MP0001119_abnormal_female_reproductive1.06423996
61* MP0001929_abnormal_gametogenesis1.03014173
62* MP0000653_abnormal_sex_gland1.01286974
63MP0001286_abnormal_eye_development0.99101804
64MP0002722_abnormal_immune_system0.98088381
65MP0000689_abnormal_spleen_morphology0.97258151
66MP0006036_abnormal_mitochondrial_physio0.97248789
67MP0008995_early_reproductive_senescence0.94170050
68MP0010030_abnormal_orbit_morphology0.93254536
69MP0002697_abnormal_eye_size0.90804409
70MP0003221_abnormal_cardiomyocyte_apopto0.88876946
71MP0001346_abnormal_lacrimal_gland0.88641385
72MP0009053_abnormal_anal_canal0.84459165
73MP0005384_cellular_phenotype0.83455003
74MP0009672_abnormal_birth_weight0.83136477
75MP0002429_abnormal_blood_cell0.82020084
76MP0002234_abnormal_pharynx_morphology0.81611582
77MP0003136_yellow_coat_color0.81488235
78* MP0002160_abnormal_reproductive_system0.80191796
79MP0002095_abnormal_skin_pigmentation0.79471188
80MP0003937_abnormal_limbs/digits/tail_de0.78443164
81MP0005621_abnormal_cell_physiology0.78348990
82MP0001915_intracranial_hemorrhage0.75967420
83MP0004215_abnormal_myocardial_fiber0.74284632
84MP0001727_abnormal_embryo_implantation0.73627088
85MP0000647_abnormal_sebaceous_gland0.73561282
86MP0000749_muscle_degeneration0.72402217
87MP0005391_vision/eye_phenotype0.72018333
88MP0000358_abnormal_cell_content/0.71321331
89MP0002092_abnormal_eye_morphology0.70912622
90MP0002102_abnormal_ear_morphology0.70830528
91MP0005408_hypopigmentation0.70673620
92MP0000858_altered_metastatic_potential0.70521272
93MP0005253_abnormal_eye_physiology0.70438531
94* MP0005389_reproductive_system_phenotype0.70252077
95MP0003705_abnormal_hypodermis_morpholog0.69670079
96MP0000631_abnormal_neuroendocrine_gland0.69150375
97MP0001293_anophthalmia0.68853379
98MP0009703_decreased_birth_body0.68395715
99MP0002111_abnormal_tail_morphology0.66905978
100MP0003943_abnormal_hepatobiliary_system0.66568864
101MP0002009_preneoplasia0.66448729
102* MP0003698_abnormal_male_reproductive0.66368489
103MP0003566_abnormal_cell_adhesion0.66353111
104MP0005266_abnormal_metabolism0.66233477
105MP0002233_abnormal_nose_morphology0.65358714
106MP0003755_abnormal_palate_morphology0.64995215
107MP0003787_abnormal_imprinting0.64820567
108MP0005501_abnormal_skin_physiology0.64640829
109MP0005394_taste/olfaction_phenotype0.64527403
110MP0005499_abnormal_olfactory_system0.64527403
111MP0003115_abnormal_respiratory_system0.64118173
112MP0000716_abnormal_immune_system0.63225984
113MP0002006_tumorigenesis0.63098666
114MP0003186_abnormal_redox_activity0.61205446
115MP0001919_abnormal_reproductive_system0.60426596
116MP0002877_abnormal_melanocyte_morpholog0.59731900
117MP0002177_abnormal_outer_ear0.57046895
118MP0002090_abnormal_vision0.56439442
119MP0001853_heart_inflammation0.56238353
120MP0009379_abnormal_foot_pigmentation0.56157995
121MP0000627_abnormal_mammary_gland0.55892923
122* MP0002161_abnormal_fertility/fecundity0.55844412
123MP0003861_abnormal_nervous_system0.54706682
124MP0003699_abnormal_female_reproductive0.54338906
125MP0002163_abnormal_gland_morphology0.54282574
126MP0003936_abnormal_reproductive_system0.53639589
127MP0002938_white_spotting0.51953076
128MP0005023_abnormal_wound_healing0.51953026
129MP0000427_abnormal_hair_cycle0.51110323
130MP0003942_abnormal_urinary_system0.51047600
131MP0003119_abnormal_digestive_system0.50115682
132MP0002420_abnormal_adaptive_immunity0.49504522
133MP0000537_abnormal_urethra_morphology0.49178632
134MP0002132_abnormal_respiratory_system0.48694679
135MP0001243_abnormal_dermal_layer0.48679098
136MP0000477_abnormal_intestine_morphology0.48393999
137MP0001819_abnormal_immune_cell0.47605742
138MP0002452_abnormal_antigen_presenting0.47576205
139MP0002405_respiratory_system_inflammati0.47023592

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.55794734
2Chromsome breakage (HP:0040012)4.90804466
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.62259532
4Abnormality of chromosome stability (HP:0003220)4.52344715
5Breast hypoplasia (HP:0003187)3.89089802
6Meckel diverticulum (HP:0002245)3.80753322
7Patellar aplasia (HP:0006443)3.63077042
8Abnormality of the ileum (HP:0001549)3.58576245
9Abnormality of the preputium (HP:0100587)3.57600089
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.52123652
11Reticulocytopenia (HP:0001896)3.46240989
12Aplasia/Hypoplasia of the patella (HP:0006498)3.39031014
13Colon cancer (HP:0003003)3.25250673
14Selective tooth agenesis (HP:0001592)3.19496579
15Duodenal stenosis (HP:0100867)3.09759291
16Small intestinal stenosis (HP:0012848)3.09759291
17Aplastic anemia (HP:0001915)2.97833930
18Increased serum pyruvate (HP:0003542)2.95195715
19Impulsivity (HP:0100710)2.93777886
20Myelodysplasia (HP:0002863)2.91346276
21Oral leukoplakia (HP:0002745)2.90314389
22Abnormality of the anterior horn cell (HP:0006802)2.88922277
23Degeneration of anterior horn cells (HP:0002398)2.88922277
24Ectopic kidney (HP:0000086)2.88591267
25Abnormal number of erythroid precursors (HP:0012131)2.85488739
26Agnosia (HP:0010524)2.83115474
27Abnormality of cells of the erythroid lineage (HP:0012130)2.82544973
28High pitched voice (HP:0001620)2.81875752
2911 pairs of ribs (HP:0000878)2.77848222
30Abnormality of the carotid arteries (HP:0005344)2.75340939
31Abnormality of glycolysis (HP:0004366)2.72768209
32Slender long bone (HP:0003100)2.71988878
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.67696587
34Medulloblastoma (HP:0002885)2.66062228
35Volvulus (HP:0002580)2.63457740
36Bone marrow hypocellularity (HP:0005528)2.55966575
37Absent thumb (HP:0009777)2.53444628
38Sloping forehead (HP:0000340)2.49581564
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.48489773
40Embryonal renal neoplasm (HP:0011794)2.48057390
41Abnormality of the duodenum (HP:0002246)2.47513237
42Nephroblastoma (Wilms tumor) (HP:0002667)2.42867324
43Increased nuchal translucency (HP:0010880)2.41865535
44Atresia of the external auditory canal (HP:0000413)2.41297141
45Microvesicular hepatic steatosis (HP:0001414)2.41039480
46Clubbing of toes (HP:0100760)2.39275263
47Acute encephalopathy (HP:0006846)2.38739770
48Glioma (HP:0009733)2.35495997
49Abnormal lung lobation (HP:0002101)2.34911415
50Papilledema (HP:0001085)2.32193413
51Short 4th metacarpal (HP:0010044)2.29127808
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29127808
53Premature graying of hair (HP:0002216)2.27955208
54Choanal atresia (HP:0000453)2.25926373
55Cafe-au-lait spot (HP:0000957)2.25048887
56Microretrognathia (HP:0000308)2.24746340
57Deviation of the thumb (HP:0009603)2.24704008
58Absent radius (HP:0003974)2.23578618
59Abnormal number of incisors (HP:0011064)2.22498038
60Astrocytoma (HP:0009592)2.18173958
61Abnormality of the astrocytes (HP:0100707)2.18173958
62Neoplasm of the pancreas (HP:0002894)2.16473508
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15324209
64Abnormality of alanine metabolism (HP:0010916)2.15324209
65Hyperalaninemia (HP:0003348)2.15324209
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.14506189
67Rhabdomyosarcoma (HP:0002859)2.12898311
68Pancytopenia (HP:0001876)2.12846448
69Proximal placement of thumb (HP:0009623)2.12692375
70Cortical dysplasia (HP:0002539)2.12084578
71Postnatal microcephaly (HP:0005484)2.11738109
72Absent epiphyses (HP:0010577)2.10991261
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.10991261
74Facial hemangioma (HP:0000329)2.09945055
75Lymphoma (HP:0002665)2.09616746
76IgM deficiency (HP:0002850)2.07306134
77Aplasia involving forearm bones (HP:0009822)2.07295091
78Absent forearm bone (HP:0003953)2.07295091
79Horseshoe kidney (HP:0000085)2.07192917
80Pallor (HP:0000980)2.06883940
81Triphalangeal thumb (HP:0001199)2.06403615
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04145697
83Acute necrotizing encephalopathy (HP:0006965)2.03010235
84Prominent nose (HP:0000448)2.02622017
85Embryonal neoplasm (HP:0002898)2.01857882
86Short thumb (HP:0009778)2.01235209
87Tracheoesophageal fistula (HP:0002575)2.01005694
88Abnormal spermatogenesis (HP:0008669)2.00995326
89Abnormality of the labia minora (HP:0012880)1.99410094
90Thrombocytosis (HP:0001894)1.98131523
91Squamous cell carcinoma (HP:0002860)1.97310521
92Tubulointerstitial nephritis (HP:0001970)1.96187527
93Cutaneous melanoma (HP:0012056)1.94872946
94Missing ribs (HP:0000921)1.93579620
95Short middle phalanx of the 5th finger (HP:0004220)1.93162498
96Cellular immunodeficiency (HP:0005374)1.92931411
97Hyperglycinemia (HP:0002154)1.92174156
98Increased CSF lactate (HP:0002490)1.91593220
99Abnormality of the calcaneus (HP:0008364)1.91334612
100Secondary amenorrhea (HP:0000869)1.91264281
101Pulmonary fibrosis (HP:0002206)1.90764199
102Basal cell carcinoma (HP:0002671)1.90246026
103Abnormality of serum amino acid levels (HP:0003112)1.89811758
104Irregular epiphyses (HP:0010582)1.89462593
105Rough bone trabeculation (HP:0100670)1.88840240
106Macrocytic anemia (HP:0001972)1.86223106
107Duplicated collecting system (HP:0000081)1.86201252
108Ependymoma (HP:0002888)1.86082669
109Abnormal mitochondria in muscle tissue (HP:0008316)1.85937314
110Acute myeloid leukemia (HP:0004808)1.85800843
111Small hand (HP:0200055)1.82974223
112Abnormality of the prostate (HP:0008775)1.82387167
113Hepatocellular necrosis (HP:0001404)1.82322168
114Neoplasm of the colon (HP:0100273)1.82267704
115Abnormality of cochlea (HP:0000375)1.82216592
116Oligohydramnios (HP:0001562)1.81517856
117Arteriovenous malformation (HP:0100026)1.80327129
118Poor head control (HP:0002421)1.79934894
119Poikilocytosis (HP:0004447)1.79524828
120Microtia (HP:0008551)1.79296369
121Increased serum lactate (HP:0002151)1.79137392
122Carpal bone hypoplasia (HP:0001498)1.79056623
123Oligodactyly (hands) (HP:0001180)1.78754894
124Abnormality of DNA repair (HP:0003254)1.77760894
125Breast carcinoma (HP:0003002)1.77566023
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76599964
127Deep philtrum (HP:0002002)1.75522592
128Mitochondrial inheritance (HP:0001427)1.73928777
129Hypoplasia of the pons (HP:0012110)1.73147954
130Abnormality of reticulocytes (HP:0004312)1.73042212
131Breast aplasia (HP:0100783)1.70929153
132Abnormality of the renal collecting system (HP:0004742)1.70800967
133Prominent metopic ridge (HP:0005487)1.70763116
134Astigmatism (HP:0000483)1.70736948
135Abnormality of the pons (HP:0007361)1.69700522
136Facial cleft (HP:0002006)1.69601452
137Congenital, generalized hypertrichosis (HP:0004540)1.69370991
138Ovarian neoplasm (HP:0100615)1.68661285
139Supernumerary spleens (HP:0009799)1.67156749
140Multiple enchondromatosis (HP:0005701)1.66420721
141Abnormality of methionine metabolism (HP:0010901)1.65589949
142Increased hepatocellular lipid droplets (HP:0006565)1.64129354
143Progressive macrocephaly (HP:0004481)1.63544032
144External ear malformation (HP:0008572)1.63389209
145Hepatic necrosis (HP:0002605)1.63039344
146Megaloblastic anemia (HP:0001889)1.61541602
147High anterior hairline (HP:0009890)1.56680553
148Cerebral edema (HP:0002181)1.55419394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC76.10283405
2WEE14.18092775
3EIF2AK13.66280314
4ACVR1B3.12608381
5BUB12.96954789
6NEK22.70174905
7SRPK12.65564233
8PLK42.55321294
9TLK12.31366723
10TTK2.31335363
11NEK12.22989666
12CCNB12.15294747
13BRSK22.13901225
14VRK12.13379824
15VRK22.11193224
16EIF2AK32.07063418
17PLK12.00248846
18ATR1.93993488
19AURKB1.86517993
20SCYL21.83948179
21MST41.82172584
22ZAK1.81128018
23MKNK11.76370175
24TRIM281.75499015
25PASK1.70851422
26NME21.65796857
27PLK31.65449776
28BRSK11.62839864
29BMPR1B1.54284185
30CHEK21.53140563
31CDK71.50397480
32RPS6KA41.46360958
33TAF11.41023624
34MAP3K81.38650727
35CDK81.32361675
36STK101.30245916
37DYRK31.27769279
38MKNK21.26051844
39STK41.25233569
40CHEK11.23005257
41CDK41.20691274
42TSSK61.19865531
43STK161.14854553
44AURKA1.13472677
45RPS6KB21.10270917
46NEK91.05941820
47MELK1.05418281
48PIM11.04748125
49CSNK1G30.99778858
50ATM0.99723321
51EEF2K0.99533175
52PLK20.99365444
53BCR0.99221845
54TGFBR10.95845769
55CSNK1A1L0.95728845
56TESK20.95589175
57STK30.94297254
58CLK10.93226497
59PNCK0.92270222
60EIF2AK20.91046232
61MAP4K20.83787887
62CSNK1G10.83255066
63CDK20.80458046
64FLT30.79564571
65CSNK1G20.77507593
66TESK10.77478421
67MAPKAPK30.76157026
68STK390.71625084
69CDK10.70208841
70BRAF0.68975306
71DAPK10.68805397
72NME10.68483046
73CDK60.68130303
74CDK120.64030514
75SIK30.62954115
76CSNK2A10.62184879
77ERBB30.60209638
78LRRK20.59881610
79WNK30.55898675
80MAP2K30.55072911
81YES10.54832677
82RPS6KA50.53036300
83CSNK2A20.52805500
84PBK0.52338006
85PIM20.52154450
86PAK40.51626267
87MAPKAPK50.49509226
88NUAK10.49279333
89PDK20.48566091
90MAP3K100.47790010
91FRK0.44697041
92LATS10.44693479
93TRPM70.42201830
94PRKD30.39387035
95PKN20.39334695
96CDK30.39238288
97MAP2K70.36601331
98MAP4K10.36051791
99CDK90.36046042
100TEC0.35502249
101PRKDC0.35282418
102RAF10.34374967
103ALK0.34218447
104CSF1R0.34020956
105CSNK1E0.32318054
106PAK10.31367985
107MST1R0.30614391
108JAK30.30572767
109MAP3K50.30202836
110IRAK40.30139196
111KDR0.29947413
112MUSK0.29469056
113LIMK10.29350733
114MAP3K60.29346019
115OXSR10.29025638
116STK38L0.26780808
117MAPK130.26437970
118CDK180.25967672
119CSNK1D0.25368622
120SMG10.24669453
121CDK150.24589467
122BTK0.24079954
123AKT10.24000568
124RPS6KB10.23207442
125MAPK140.22769664
126BRD40.22711355
127ERBB40.22079458
128ILK0.22074493
129CDK11A0.21925074
130STK240.21458798
131MINK10.20989977
132KIT0.20969561
133DYRK20.20807600
134CDK140.20398727
135INSRR0.20366388

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.26161706
2Mismatch repair_Homo sapiens_hsa034304.99961932
3Homologous recombination_Homo sapiens_hsa034403.55702396
4Base excision repair_Homo sapiens_hsa034103.45485561
5* Cell cycle_Homo sapiens_hsa041103.39161508
6Nucleotide excision repair_Homo sapiens_hsa034203.24986785
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94256696
8RNA transport_Homo sapiens_hsa030132.84521026
9Spliceosome_Homo sapiens_hsa030402.82313533
10Fanconi anemia pathway_Homo sapiens_hsa034602.78007368
11One carbon pool by folate_Homo sapiens_hsa006702.71313096
12RNA polymerase_Homo sapiens_hsa030202.45925401
13Pyrimidine metabolism_Homo sapiens_hsa002402.43902304
14Non-homologous end-joining_Homo sapiens_hsa034502.37674447
15Proteasome_Homo sapiens_hsa030502.36953367
16Ribosome_Homo sapiens_hsa030102.12433758
17Systemic lupus erythematosus_Homo sapiens_hsa053222.05327920
18RNA degradation_Homo sapiens_hsa030181.96582401
19Basal transcription factors_Homo sapiens_hsa030221.81042223
20* p53 signaling pathway_Homo sapiens_hsa041151.79707273
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76969757
22mRNA surveillance pathway_Homo sapiens_hsa030151.60033755
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35899408
24Purine metabolism_Homo sapiens_hsa002301.33267431
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29385638
26Propanoate metabolism_Homo sapiens_hsa006401.25749265
27Parkinsons disease_Homo sapiens_hsa050121.25466812
28* Viral carcinogenesis_Homo sapiens_hsa052031.21249703
29Oxidative phosphorylation_Homo sapiens_hsa001901.17962106
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13008391
31Epstein-Barr virus infection_Homo sapiens_hsa051691.09031695
32Steroid biosynthesis_Homo sapiens_hsa001001.07222530
33Pyruvate metabolism_Homo sapiens_hsa006201.05220533
34* Oocyte meiosis_Homo sapiens_hsa041141.05117988
35Herpes simplex infection_Homo sapiens_hsa051681.01259587
36Alcoholism_Homo sapiens_hsa050340.99379158
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96670073
38Fatty acid elongation_Homo sapiens_hsa000620.96121576
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89877512
40Antigen processing and presentation_Homo sapiens_hsa046120.89541646
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88705658
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86037453
43HTLV-I infection_Homo sapiens_hsa051660.84537215
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84369317
45Protein export_Homo sapiens_hsa030600.76938136
46Pentose phosphate pathway_Homo sapiens_hsa000300.76283997
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75816282
48* MicroRNAs in cancer_Homo sapiens_hsa052060.75598276
49* Small cell lung cancer_Homo sapiens_hsa052220.75334557
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69271914
51Selenocompound metabolism_Homo sapiens_hsa004500.68243777
52Legionellosis_Homo sapiens_hsa051340.67674440
53Alzheimers disease_Homo sapiens_hsa050100.65785062
54N-Glycan biosynthesis_Homo sapiens_hsa005100.62779445
55Sulfur relay system_Homo sapiens_hsa041220.62210207
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60707577
57Folate biosynthesis_Homo sapiens_hsa007900.60589654
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59883971
59* Hepatitis B_Homo sapiens_hsa051610.59621090
60Thyroid cancer_Homo sapiens_hsa052160.57787214
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56635069
62TGF-beta signaling pathway_Homo sapiens_hsa043500.54048816
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.53033313
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52874678
65Apoptosis_Homo sapiens_hsa042100.52265081
66Biosynthesis of amino acids_Homo sapiens_hsa012300.50946879
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49202278
68Colorectal cancer_Homo sapiens_hsa052100.44394300
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43564503
70Shigellosis_Homo sapiens_hsa051310.43005917
71Chronic myeloid leukemia_Homo sapiens_hsa052200.42532885
72Glutathione metabolism_Homo sapiens_hsa004800.41848209
73Pancreatic cancer_Homo sapiens_hsa052120.39534902
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.39021354
75Bladder cancer_Homo sapiens_hsa052190.38570083
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38217606
77* Measles_Homo sapiens_hsa051620.37387759
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35222885
79Viral myocarditis_Homo sapiens_hsa054160.35083717
80Primary immunodeficiency_Homo sapiens_hsa053400.34263015
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34066935
82Regulation of autophagy_Homo sapiens_hsa041400.32561286
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.32148843
84Fatty acid metabolism_Homo sapiens_hsa012120.31978728
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31528384
86Hematopoietic cell lineage_Homo sapiens_hsa046400.29753959
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29338777
88Influenza A_Homo sapiens_hsa051640.28927653
89Adherens junction_Homo sapiens_hsa045200.27362434
90Huntingtons disease_Homo sapiens_hsa050160.27310530
91Peroxisome_Homo sapiens_hsa041460.27027526
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.26820336
93HIF-1 signaling pathway_Homo sapiens_hsa040660.26414051
94Butanoate metabolism_Homo sapiens_hsa006500.25498314
95* Prostate cancer_Homo sapiens_hsa052150.23290368
96Non-small cell lung cancer_Homo sapiens_hsa052230.23040027
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22840995
98Hippo signaling pathway_Homo sapiens_hsa043900.22630947
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21448334
100Carbon metabolism_Homo sapiens_hsa012000.21055782
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20465901
102Basal cell carcinoma_Homo sapiens_hsa052170.20310981
103* Pathways in cancer_Homo sapiens_hsa052000.17756923
104Sulfur metabolism_Homo sapiens_hsa009200.17563949
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17441054
106FoxO signaling pathway_Homo sapiens_hsa040680.15807924
107Renin-angiotensin system_Homo sapiens_hsa046140.15037044
108Caffeine metabolism_Homo sapiens_hsa002320.13860963
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.12496664
110Melanoma_Homo sapiens_hsa052180.12155105
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10570324
112Hedgehog signaling pathway_Homo sapiens_hsa043400.10277431
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.10206506
114Wnt signaling pathway_Homo sapiens_hsa043100.09526164
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.08870209
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08584927
117Leishmaniasis_Homo sapiens_hsa051400.06521474
118* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05466850
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.05416089
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.05005721
121Fatty acid degradation_Homo sapiens_hsa000710.04937915
122Proteoglycans in cancer_Homo sapiens_hsa052050.04015661
123Vitamin B6 metabolism_Homo sapiens_hsa007500.03877316
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.03690284
125Toxoplasmosis_Homo sapiens_hsa051450.03339372
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03303027
127Lysine degradation_Homo sapiens_hsa003100.03236124
128Metabolic pathways_Homo sapiens_hsa011000.03045668
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.02797628
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.02030087
131Phototransduction_Homo sapiens_hsa047440.01817472
132Fructose and mannose metabolism_Homo sapiens_hsa000510.00949274
133Arginine and proline metabolism_Homo sapiens_hsa003300.00697208
134Cardiac muscle contraction_Homo sapiens_hsa04260-0.0016124

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