CCNF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.50059926
2DNA unwinding involved in DNA replication (GO:0006268)5.15725661
3mitotic sister chromatid segregation (GO:0000070)5.11771714
4mitotic metaphase plate congression (GO:0007080)4.91158633
5protein localization to chromosome, centromeric region (GO:0071459)4.77462212
6sister chromatid segregation (GO:0000819)4.70337932
7DNA replication initiation (GO:0006270)4.67685730
8DNA topological change (GO:0006265)4.65188308
9DNA strand elongation involved in DNA replication (GO:0006271)4.58834486
10DNA replication-dependent nucleosome organization (GO:0034723)4.56694284
11DNA replication-dependent nucleosome assembly (GO:0006335)4.56694284
12nuclear pore organization (GO:0006999)4.52795779
13mitotic nuclear envelope disassembly (GO:0007077)4.49305251
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.44715249
15mitotic chromosome condensation (GO:0007076)4.42825018
16regulation of spindle organization (GO:0090224)4.39689555
17DNA strand elongation (GO:0022616)4.35518433
18metaphase plate congression (GO:0051310)4.28493635
19nuclear pore complex assembly (GO:0051292)4.25109560
20DNA ligation (GO:0006266)4.22833367
21kinetochore organization (GO:0051383)4.19167514
22nuclear envelope disassembly (GO:0051081)4.17068858
23membrane disassembly (GO:0030397)4.17068858
24DNA replication checkpoint (GO:0000076)4.15674181
25telomere maintenance via semi-conservative replication (GO:0032201)4.11919172
26folic acid-containing compound biosynthetic process (GO:0009396)4.11488420
27attachment of spindle microtubules to kinetochore (GO:0008608)4.11423071
28nucleobase biosynthetic process (GO:0046112)4.10905150
29positive regulation of chromosome segregation (GO:0051984)4.07708742
30establishment of chromosome localization (GO:0051303)3.96488013
31IMP biosynthetic process (GO:0006188)3.90755808
32chromatin remodeling at centromere (GO:0031055)3.89549658
33CENP-A containing nucleosome assembly (GO:0034080)3.87611294
34formation of translation preinitiation complex (GO:0001731)3.82474275
35establishment of integrated proviral latency (GO:0075713)3.81470439
36regulation of mitotic spindle organization (GO:0060236)3.81406912
37regulation of gene silencing by RNA (GO:0060966)3.74967821
38regulation of posttranscriptional gene silencing (GO:0060147)3.74967821
39regulation of gene silencing by miRNA (GO:0060964)3.74967821
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.73763899
41purine nucleobase biosynthetic process (GO:0009113)3.70859671
42kinetochore assembly (GO:0051382)3.70440070
43mitotic recombination (GO:0006312)3.69601448
44DNA replication-independent nucleosome assembly (GO:0006336)3.68633927
45DNA replication-independent nucleosome organization (GO:0034724)3.68633927
46telomere maintenance via recombination (GO:0000722)3.68305012
47regulation of chromosome segregation (GO:0051983)3.66118286
48DNA geometric change (GO:0032392)3.60230789
49DNA duplex unwinding (GO:0032508)3.60029128
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.58965722
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58965722
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58965722
53protein complex localization (GO:0031503)3.56017946
54spindle checkpoint (GO:0031577)3.54987220
55negative regulation of chromosome segregation (GO:0051985)3.54536150
56protein localization to chromosome (GO:0034502)3.52656358
57DNA packaging (GO:0006323)3.52076469
58negative regulation of mitotic sister chromatid separation (GO:2000816)3.45211879
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.45211879
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.45211879
61negative regulation of sister chromatid segregation (GO:0033046)3.45211879
62maturation of SSU-rRNA (GO:0030490)3.44388215
63telomere maintenance via telomere lengthening (GO:0010833)3.44097342
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.43823387
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43823387
66spindle assembly checkpoint (GO:0071173)3.43561489
67meiotic chromosome segregation (GO:0045132)3.43225992
68regulation of centriole replication (GO:0046599)3.41002635
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40246066
70chromosome segregation (GO:0007059)3.37872245
71IMP metabolic process (GO:0046040)3.36530204
72mitotic spindle assembly checkpoint (GO:0007094)3.36376812
73histone exchange (GO:0043486)3.35566446
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34197095
75mitotic spindle checkpoint (GO:0071174)3.32953152
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31847501
77chromatin assembly or disassembly (GO:0006333)3.31329641
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.30302447
79pore complex assembly (GO:0046931)3.26814322
80regulation of mitotic sister chromatid separation (GO:0010965)3.25996636
81regulation of mitotic sister chromatid segregation (GO:0033047)3.25996636
82regulation of sister chromatid segregation (GO:0033045)3.25996636
83heterochromatin organization (GO:0070828)3.25414990
84regulation of histone H3-K9 methylation (GO:0051570)3.24693791
85protein K6-linked ubiquitination (GO:0085020)3.23301582
86nuclear envelope organization (GO:0006998)3.21704903
87DNA strand renaturation (GO:0000733)3.21504557
88ribosome biogenesis (GO:0042254)3.20972625
89regulation of sister chromatid cohesion (GO:0007063)3.18936115
90DNA synthesis involved in DNA repair (GO:0000731)3.18382052
91ribosome assembly (GO:0042255)3.16327046
92double-strand break repair via nonhomologous end joining (GO:0006303)3.14712516
93non-recombinational repair (GO:0000726)3.14712516
94pre-miRNA processing (GO:0031054)3.14589489
95DNA conformation change (GO:0071103)3.12977570
96regulation of translational fidelity (GO:0006450)3.12053287
97chromosome condensation (GO:0030261)3.09269536
98negative regulation of histone methylation (GO:0031061)3.08099311
99regulation of telomere maintenance via telomerase (GO:0032210)3.04407842
100microtubule depolymerization (GO:0007019)3.04372948
101V(D)J recombination (GO:0033151)3.04015652
102* regulation of centrosome cycle (GO:0046605)3.02212529
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01185001
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00444587
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00063408
106chromatin assembly (GO:0031497)2.98392526
107spindle organization (GO:0007051)2.98087711
108regulation of spindle checkpoint (GO:0090231)2.97490263
109negative regulation of mitosis (GO:0045839)2.97461010
110regulation of helicase activity (GO:0051095)2.95256170
111ribosomal small subunit assembly (GO:0000028)2.94574740
112ATP-dependent chromatin remodeling (GO:0043044)2.94189647
113spindle assembly involved in mitosis (GO:0090307)2.93467586
114chromosome organization (GO:0051276)2.93040785
115viral mRNA export from host cell nucleus (GO:0046784)2.92790659
116mitotic sister chromatid cohesion (GO:0007064)2.92758510
117ribonucleoprotein complex biogenesis (GO:0022613)2.92616588
118mitotic cell cycle (GO:0000278)2.90588982
119regulation of double-strand break repair via homologous recombination (GO:0010569)2.88511719
120establishment of viral latency (GO:0019043)2.86770084
121negative regulation of mRNA processing (GO:0050686)2.83416552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.14653768
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.66835661
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03461706
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.93423327
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.60206444
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48784210
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94933979
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69117433
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51450197
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40443443
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39725530
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.37508574
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31118592
14AR_21909140_ChIP-Seq_LNCAP_Human2.30864965
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.21206345
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19932461
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15494541
18XRN2_22483619_ChIP-Seq_HELA_Human2.14174779
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.12146838
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06077138
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.05651095
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05371661
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03679977
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01286567
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98449172
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.96288843
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.90781649
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84525643
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83334728
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82569004
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82402218
32VDR_23849224_ChIP-Seq_CD4+_Human1.74322594
33MYC_22102868_ChIP-Seq_BL_Human1.69368553
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64486888
35FOXP3_21729870_ChIP-Seq_TREG_Human1.63223979
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62997181
37DCP1A_22483619_ChIP-Seq_HELA_Human1.61008979
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57243849
39TTF2_22483619_ChIP-Seq_HELA_Human1.56008834
40CIITA_25753668_ChIP-Seq_RAJI_Human1.51824582
41GABP_19822575_ChIP-Seq_HepG2_Human1.51750039
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49774589
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49774589
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49774589
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49662886
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47436628
47KDM5A_27292631_Chip-Seq_BREAST_Human1.42331072
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41628781
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40943347
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40329572
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38590194
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35497528
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34055226
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33553521
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.32051624
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30162304
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29912956
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29754851
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28487755
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26242420
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25735477
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25114299
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22316881
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20619929
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20241229
66ELK1_19687146_ChIP-ChIP_HELA_Human1.20131615
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.19194612
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17975162
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16471760
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14039560
71TFEB_21752829_ChIP-Seq_HELA_Human1.13328218
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12683851
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.10303901
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08907456
75* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08616229
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06359476
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04754787
78* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04140352
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02491081
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.01515789
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01491504
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99855823
83VDR_21846776_ChIP-Seq_THP-1_Human0.99296247
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98088437
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97606703
86ZNF263_19887448_ChIP-Seq_K562_Human0.97424245
87SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97168700
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97108745
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96172156
90MYC_18940864_ChIP-ChIP_HL60_Human0.95898293
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95739820
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94528084
93* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91868948
94SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91738225
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91190052
96SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91177638
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90874686
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90258601
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89908969
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.89367005
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89302593
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88071302
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86716738
104CHD1_26751641_Chip-Seq_LNCaP_Human0.86211652
105SRF_21415370_ChIP-Seq_HL-1_Mouse0.85770548
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85491462
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.85475096
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85276598
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84283884
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84003325
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.81739351
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81315346
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81174554
114* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80714709
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78483008
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76803188
117FOXP1_21924763_ChIP-Seq_HESCs_Human0.75764248
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74296007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.32594504
2MP0003111_abnormal_nucleus_morphology5.06894884
3MP0010094_abnormal_chromosome_stability4.86046899
4MP0004957_abnormal_blastocyst_morpholog4.53740630
5* MP0003077_abnormal_cell_cycle4.15501645
6MP0008057_abnormal_DNA_replication4.06244211
7MP0008058_abnormal_DNA_repair3.02419853
8MP0001730_embryonic_growth_arrest2.73715670
9MP0008007_abnormal_cellular_replicative2.63866960
10MP0008932_abnormal_embryonic_tissue2.58835405
11MP0003123_paternal_imprinting2.58015185
12MP0010352_gastrointestinal_tract_polyps2.54856762
13* MP0000350_abnormal_cell_proliferation2.44059653
14MP0010307_abnormal_tumor_latency2.34144669
15MP0005380_embryogenesis_phenotype2.10248479
16MP0001672_abnormal_embryogenesis/_devel2.10248479
17* MP0001697_abnormal_embryo_size2.00232812
18MP0008877_abnormal_DNA_methylation1.92232381
19MP0003984_embryonic_growth_retardation1.85505225
20* MP0002085_abnormal_embryonic_tissue1.85457724
21MP0002088_abnormal_embryonic_growth/wei1.82091277
22MP0005076_abnormal_cell_differentiation1.82003263
23* MP0002080_prenatal_lethality1.81115510
24MP0003806_abnormal_nucleotide_metabolis1.79980186
25MP0004197_abnormal_fetal_growth/weight/1.78766313
26* MP0002084_abnormal_developmental_patter1.77176517
27* MP0002086_abnormal_extraembryonic_tissu1.76836772
28MP0003786_premature_aging1.75821986
29MP0002396_abnormal_hematopoietic_system1.70579652
30MP0010030_abnormal_orbit_morphology1.60659196
31MP0009697_abnormal_copulation1.60626436
32MP0003121_genomic_imprinting1.55223247
33MP0000490_abnormal_crypts_of1.51801872
34MP0003718_maternal_effect1.51429127
35MP0003705_abnormal_hypodermis_morpholog1.50593362
36MP0000313_abnormal_cell_death1.46277312
37MP0003567_abnormal_fetal_cardiomyocyte1.46120258
38MP0003890_abnormal_embryonic-extraembry1.44372962
39MP0001346_abnormal_lacrimal_gland1.41222539
40MP0002019_abnormal_tumor_incidence1.40491335
41MP0002653_abnormal_ependyma_morphology1.37324033
42MP0004133_heterotaxia1.35379653
43MP0004233_abnormal_muscle_weight1.33483336
44MP0003119_abnormal_digestive_system1.30711358
45MP0001293_anophthalmia1.27001467
46MP0006035_abnormal_mitochondrial_morpho1.25864191
47MP0009053_abnormal_anal_canal1.21411895
48MP0003941_abnormal_skin_development1.16593322
49MP0002210_abnormal_sex_determination1.14988585
50MP0000537_abnormal_urethra_morphology1.13372660
51MP0004808_abnormal_hematopoietic_stem1.11706408
52MP0009672_abnormal_birth_weight1.08924171
53MP0001545_abnormal_hematopoietic_system1.08324045
54MP0005397_hematopoietic_system_phenotyp1.08324045
55MP0001145_abnormal_male_reproductive1.07517605
56MP0005171_absent_coat_pigmentation1.06750054
57MP0004264_abnormal_extraembryonic_tissu1.05416363
58MP0001661_extended_life_span1.04762307
59MP0001849_ear_inflammation1.04365194
60MP0002111_abnormal_tail_morphology1.00867967
61MP0003566_abnormal_cell_adhesion0.99958327
62MP0002877_abnormal_melanocyte_morpholog0.98535360
63MP0003315_abnormal_perineum_morphology0.97598629
64MP0005023_abnormal_wound_healing0.93795684
65MP0009703_decreased_birth_body0.93434210
66MP0005623_abnormal_meninges_morphology0.93289315
67MP0009278_abnormal_bone_marrow0.91462751
68MP0001915_intracranial_hemorrhage0.90296829
69MP0001929_abnormal_gametogenesis0.90137595
70MP0005083_abnormal_biliary_tract0.89411425
71MP0009333_abnormal_splenocyte_physiolog0.88961148
72MP0002938_white_spotting0.88854027
73MP0002009_preneoplasia0.88624348
74MP0000703_abnormal_thymus_morphology0.88292444
75MP0004185_abnormal_adipocyte_glucose0.87207867
76MP0003136_yellow_coat_color0.87197220
77MP0005384_cellular_phenotype0.86867064
78MP0000653_abnormal_sex_gland0.86493891
79MP0001529_abnormal_vocalization0.86436453
80MP0010234_abnormal_vibrissa_follicle0.85436902
81MP0005621_abnormal_cell_physiology0.84344251
82MP0000358_abnormal_cell_content/0.81562651
83MP0003656_abnormal_erythrocyte_physiolo0.81015354
84MP0002722_abnormal_immune_system0.79800147
85MP0005501_abnormal_skin_physiology0.78683612
86MP0006292_abnormal_olfactory_placode0.77671803
87MP0002092_abnormal_eye_morphology0.75447843
88MP0000566_synostosis0.75229653
89MP0003385_abnormal_body_wall0.74826084
90MP0000689_abnormal_spleen_morphology0.73220159
91MP0000858_altered_metastatic_potential0.72926386
92MP0002160_abnormal_reproductive_system0.72714527
93MP0003755_abnormal_palate_morphology0.72239367
94MP0003943_abnormal_hepatobiliary_system0.72229873
95MP0001286_abnormal_eye_development0.72213752
96MP0000428_abnormal_craniofacial_morphol0.72206807
97* MP0003937_abnormal_limbs/digits/tail_de0.71366973
98MP0002163_abnormal_gland_morphology0.71121581
99MP0002398_abnormal_bone_marrow0.71058257
100MP0003942_abnormal_urinary_system0.70778887
101MP0001727_abnormal_embryo_implantation0.69757789
102MP0002697_abnormal_eye_size0.69535074
103MP0000049_abnormal_middle_ear0.66714445
104MP0002233_abnormal_nose_morphology0.66307200
105MP0008770_decreased_survivor_rate0.66272230
106MP0002098_abnormal_vibrissa_morphology0.66195363
107MP0000477_abnormal_intestine_morphology0.66189214
108MP0002796_impaired_skin_barrier0.66080870
109MP0005389_reproductive_system_phenotype0.65405540
110MP0008995_early_reproductive_senescence0.64111373
111MP0003115_abnormal_respiratory_system0.64062650
112MP0003186_abnormal_redox_activity0.63750164
113MP0001119_abnormal_female_reproductive0.62398812
114MP0000432_abnormal_head_morphology0.62157814
115MP0005266_abnormal_metabolism0.61879802
116* MP0002925_abnormal_cardiovascular_devel0.60772792
117MP0003221_abnormal_cardiomyocyte_apopto0.60322898
118* MP0003861_abnormal_nervous_system0.59863854
119MP0002249_abnormal_larynx_morphology0.59514438
120MP0003935_abnormal_craniofacial_develop0.55319709
121MP0002429_abnormal_blood_cell0.54768476
122MP0003283_abnormal_digestive_organ0.52282112
123MP0004147_increased_porphyrin_level0.51919150
124MP0000266_abnormal_heart_morphology0.51502959
125MP0000733_abnormal_muscle_development0.50657954
126MP0003699_abnormal_female_reproductive0.47953513
127MP0002161_abnormal_fertility/fecundity0.47827655
128MP0006054_spinal_hemorrhage0.47099724

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.50345720
2Ependymoma (HP:0002888)4.31051576
3Chromsome breakage (HP:0040012)3.96434030
4Breast hypoplasia (HP:0003187)3.95643622
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87736047
6Medulloblastoma (HP:0002885)3.60300373
7Selective tooth agenesis (HP:0001592)3.56969640
8Patellar aplasia (HP:0006443)3.43456048
9Colon cancer (HP:0003003)3.42913289
10Reticulocytopenia (HP:0001896)3.38542573
11Abnormality of the labia minora (HP:0012880)3.35556214
12Agnosia (HP:0010524)3.23436865
13Impulsivity (HP:0100710)3.21433810
14Aplasia/Hypoplasia of the patella (HP:0006498)3.18693621
15Carpal bone hypoplasia (HP:0001498)3.17181828
16Absent radius (HP:0003974)3.15507411
17Oral leukoplakia (HP:0002745)3.12927989
18Meckel diverticulum (HP:0002245)3.10717551
19Rhabdomyosarcoma (HP:0002859)3.08648040
20Abnormality of chromosome stability (HP:0003220)3.02105169
21Abnormality of the ileum (HP:0001549)2.97723684
22Aplasia involving forearm bones (HP:0009822)2.93693186
23Absent forearm bone (HP:0003953)2.93693186
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.87387482
25Astrocytoma (HP:0009592)2.86069151
26Abnormality of the astrocytes (HP:0100707)2.86069151
27Abnormality of the preputium (HP:0100587)2.81663426
28Small intestinal stenosis (HP:0012848)2.79977622
29Duodenal stenosis (HP:0100867)2.79977622
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.76729249
31Supernumerary spleens (HP:0009799)2.74677627
32Abnormality of the anterior horn cell (HP:0006802)2.74151492
33Degeneration of anterior horn cells (HP:0002398)2.74151492
34Absent thumb (HP:0009777)2.73651931
35Cortical dysplasia (HP:0002539)2.72718180
36Basal cell carcinoma (HP:0002671)2.67602634
37Abnormal lung lobation (HP:0002101)2.67555766
38Poikiloderma (HP:0001029)2.62541668
39Broad distal phalanx of finger (HP:0009836)2.61794387
40Increased nuchal translucency (HP:0010880)2.60099771
41Myelodysplasia (HP:0002863)2.57174395
42Abnormality of cells of the erythroid lineage (HP:0012130)2.55880891
43Proximal placement of thumb (HP:0009623)2.53566435
44Missing ribs (HP:0000921)2.51746843
45Deviation of the thumb (HP:0009603)2.49519850
46Rough bone trabeculation (HP:0100670)2.48324133
47Abnormal number of incisors (HP:0011064)2.48089967
48Neoplasm of the pancreas (HP:0002894)2.47995208
49Glioma (HP:0009733)2.47392881
50Progressive muscle weakness (HP:0003323)2.46874369
51Neoplasm of the oral cavity (HP:0100649)2.45926978
52Neoplasm of striated muscle (HP:0009728)2.45291174
53Abnormality of abdominal situs (HP:0011620)2.41395232
54Abdominal situs inversus (HP:0003363)2.41395232
55Abnormality of the duodenum (HP:0002246)2.41092145
56Microvesicular hepatic steatosis (HP:0001414)2.38761299
57Sloping forehead (HP:0000340)2.37192079
58Abnormal number of erythroid precursors (HP:0012131)2.36243706
59Aplasia/hypoplasia of the humerus (HP:0006507)2.35901709
60Cafe-au-lait spot (HP:0000957)2.35221253
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33159866
6211 pairs of ribs (HP:0000878)2.33129076
63Abnormality of DNA repair (HP:0003254)2.32834006
64Ectopic kidney (HP:0000086)2.29737294
65Bone marrow hypocellularity (HP:0005528)2.27058656
66Abnormality of reticulocytes (HP:0004312)2.26076438
67Tracheoesophageal fistula (HP:0002575)2.25986044
68Horseshoe kidney (HP:0000085)2.22738155
69Abnormality of pyrimidine metabolism (HP:0004353)2.22205433
70Atresia of the external auditory canal (HP:0000413)2.21918662
71Embryonal neoplasm (HP:0002898)2.19112816
72Nephroblastoma (Wilms tumor) (HP:0002667)2.18134442
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.16642476
74Duplicated collecting system (HP:0000081)2.16376276
75Squamous cell carcinoma (HP:0002860)2.16197768
76Clubbing of toes (HP:0100760)2.14994856
77Trismus (HP:0000211)2.14305581
78Rib fusion (HP:0000902)2.12234919
79Hyperacusis (HP:0010780)2.10874419
80Absent epiphyses (HP:0010577)2.10865794
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.10865794
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09711332
83Biliary tract neoplasm (HP:0100574)2.08646582
84High pitched voice (HP:0001620)2.08588501
85Short humerus (HP:0005792)2.08223958
86Arteriovenous malformation (HP:0100026)2.07417759
87Facial hemangioma (HP:0000329)2.06765712
88Multiple enchondromatosis (HP:0005701)2.06243634
89Cerebral hypomyelination (HP:0006808)2.05410074
90Cellular immunodeficiency (HP:0005374)2.04769672
91Choanal atresia (HP:0000453)2.04330221
92Duplication of thumb phalanx (HP:0009942)2.04256165
93Volvulus (HP:0002580)2.03176461
94Abnormality of cochlea (HP:0000375)2.02432910
95Embryonal renal neoplasm (HP:0011794)2.02169208
96Amaurosis fugax (HP:0100576)2.00870791
97Premature ovarian failure (HP:0008209)2.00593442
98Premature graying of hair (HP:0002216)2.00470881
99Macrocytic anemia (HP:0001972)2.00094631
100Insomnia (HP:0100785)1.98763275
101Neoplasm of the colon (HP:0100273)1.97263288
102Short thumb (HP:0009778)1.96654785
103Septate vagina (HP:0001153)1.96652564
104Prominent nose (HP:0000448)1.96532739
105Abnormality of the carotid arteries (HP:0005344)1.95708952
106Ovarian neoplasm (HP:0100615)1.94532679
107Abnormality of the heme biosynthetic pathway (HP:0010472)1.94035768
108Short 4th metacarpal (HP:0010044)1.90694360
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90694360
110High anterior hairline (HP:0009890)1.90437985
111Overlapping toe (HP:0001845)1.89243821
112Hypoplasia of the pons (HP:0012110)1.88163063
113Gastrointestinal carcinoma (HP:0002672)1.88055415
114Malignant gastrointestinal tract tumors (HP:0006749)1.88055415
115Progressive external ophthalmoplegia (HP:0000590)1.87259720
116Triphalangeal thumb (HP:0001199)1.86310149
117Entropion (HP:0000621)1.85114018
118Adenoma sebaceum (HP:0009720)1.84641164
119Angiofibromas (HP:0010615)1.84641164
120Cholecystitis (HP:0001082)1.82583007
121Abnormal gallbladder physiology (HP:0012438)1.82583007
122Small epiphyses (HP:0010585)1.82355204
123Pallor (HP:0000980)1.81924893
124Shawl scrotum (HP:0000049)1.81478249
125Abnormality of the renal collecting system (HP:0004742)1.81474195
126Aplastic anemia (HP:0001915)1.80584488
127Overriding aorta (HP:0002623)1.79611083
128Abnormality of chromosome segregation (HP:0002916)1.79559463
129Ureteral duplication (HP:0000073)1.75942893
130Ulnar bowing (HP:0003031)1.75195535
131Hypoplastic pelvis (HP:0008839)1.72696420
132Abnormality of the pons (HP:0007361)1.71425441
133Facial cleft (HP:0002006)1.70512173
134Abnormality of the fetal cardiovascular system (HP:0010948)1.70324557
135Abnormal umbilical cord blood vessels (HP:0011403)1.70324557
136Single umbilical artery (HP:0001195)1.70324557
137Abnormality of the umbilical cord (HP:0010881)1.69576318
138Deep philtrum (HP:0002002)1.66225295
139Neoplasm of the adrenal cortex (HP:0100641)1.65028241
140Abnormality of glycolysis (HP:0004366)1.63764385
141Capillary hemangiomas (HP:0005306)1.63024052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.14033792
2CDC74.31301323
3WEE14.15852083
4NEK23.30773957
5CDK122.98494473
6TTK2.91817429
7NEK12.85927718
8SMG12.50872046
9EIF2AK12.40794190
10VRK22.25158439
11PLK12.24318679
12EPHA22.10329271
13TSSK62.09455641
14BRSK22.02412210
15RPS6KB21.97351410
16SRPK11.97185211
17EEF2K1.94551449
18PLK41.85157597
19AURKB1.83863189
20TLK11.82661812
21STK101.78773350
22CDK71.78648918
23MAP3K81.66639613
24PASK1.65478357
25PLK31.61801354
26STK41.61403526
27CHEK21.60969520
28BRSK11.59474256
29ATR1.59058878
30CDK41.58320783
31TESK21.56081216
32MAP3K101.53719153
33TAF11.53205043
34AURKA1.51480692
35CHEK11.38137126
36VRK11.35560049
37MKNK11.29829896
38ACVR1B1.28440732
39BRD41.23657491
40PAK41.15970230
41DYRK31.15135567
42PKN21.12875629
43SCYL21.08489277
44NME21.04076730
45MELK1.02993432
46CDK80.97209206
47CDK20.97129752
48CDK60.96676788
49ATM0.96576459
50EIF2AK30.96544648
51RPS6KA40.93530365
52PIM10.92365192
53ZAK0.90169952
54CCNB10.90092829
55MKNK20.89785363
56ALK0.89361046
57FLT30.88438935
58TRIM280.87153536
59PNCK0.77141277
60TGFBR10.76431295
61CDK10.75337681
62NME10.73168395
63IRAK30.72921683
64PAK10.72601672
65MST1R0.71629134
66GRK60.71026079
67MST40.69664000
68MAPKAPK30.68975495
69STK30.68220078
70PRKCI0.67110696
71MTOR0.67049718
72CSNK2A20.61124152
73PBK0.60036088
74LATS20.59569370
75AKT20.54966399
76BRAF0.54868952
77CSNK2A10.53972284
78AKT30.53919195
79STK160.51351127
80NUAK10.50660570
81LRRK20.50272318
82CLK10.50271027
83CDK180.47555850
84ICK0.47295981
85TESK10.46748764
86STK38L0.44520214
87RPS6KA50.44261187
88CSNK1G30.41422564
89CSNK1A1L0.40996074
90CSNK1E0.40109968
91CDK140.39151587
92PRKDC0.37935881
93CSNK1D0.37708963
94EIF2AK20.35818636
95MAPK110.33945445
96CDK90.33524039
97MAP2K30.33495750
98SIK10.32429136
99MAPK140.31786302
100CSNK1G10.31467922
101MAP3K110.30554551
102KDR0.29876008
103MARK30.29699781
104RAF10.25958063
105MAP4K10.25581337
106AKT10.25499345
107MET0.25472843
108LATS10.24629534
109MAPK10.24541567
110BMX0.24506118
111CDK11A0.24187680
112TRIB30.24162261
113PAK20.23702346
114PDK30.22860218
115PDK40.22860218
116CDK150.22433999
117FGFR10.22412469
118MAPKAPK50.22253537
119GSK3B0.22202286
120ERBB40.22166167
121CAMK1D0.21997131
122CDK30.19969554
123IRAK20.19942245

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02266662
2Mismatch repair_Homo sapiens_hsa034304.54566161
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57128677
4RNA transport_Homo sapiens_hsa030133.28612421
5Spliceosome_Homo sapiens_hsa030403.28109145
6One carbon pool by folate_Homo sapiens_hsa006703.16752420
7Base excision repair_Homo sapiens_hsa034103.15692267
8Cell cycle_Homo sapiens_hsa041103.15163705
9Homologous recombination_Homo sapiens_hsa034403.04418541
10Nucleotide excision repair_Homo sapiens_hsa034202.90749637
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75196029
12RNA polymerase_Homo sapiens_hsa030202.61938744
13Ribosome_Homo sapiens_hsa030102.55745682
14Proteasome_Homo sapiens_hsa030502.42885663
15Fanconi anemia pathway_Homo sapiens_hsa034602.36182525
16Pyrimidine metabolism_Homo sapiens_hsa002402.09780457
17Non-homologous end-joining_Homo sapiens_hsa034502.04289433
18mRNA surveillance pathway_Homo sapiens_hsa030151.97169882
19p53 signaling pathway_Homo sapiens_hsa041151.81849567
20Systemic lupus erythematosus_Homo sapiens_hsa053221.80597046
21RNA degradation_Homo sapiens_hsa030181.78162318
22Basal transcription factors_Homo sapiens_hsa030221.65138224
23Oocyte meiosis_Homo sapiens_hsa041141.25811940
24Biosynthesis of amino acids_Homo sapiens_hsa012301.25174362
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23747541
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20481369
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19977380
28Viral carcinogenesis_Homo sapiens_hsa052031.18494218
29Epstein-Barr virus infection_Homo sapiens_hsa051691.10294926
30Selenocompound metabolism_Homo sapiens_hsa004501.09341986
31Vitamin B6 metabolism_Homo sapiens_hsa007501.04276831
32Purine metabolism_Homo sapiens_hsa002301.00510924
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.98664805
34Steroid biosynthesis_Homo sapiens_hsa001000.97159581
35Pentose phosphate pathway_Homo sapiens_hsa000300.95883360
36Pyruvate metabolism_Homo sapiens_hsa006200.95326828
37N-Glycan biosynthesis_Homo sapiens_hsa005100.95198482
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.93480684
39MicroRNAs in cancer_Homo sapiens_hsa052060.86255473
40Folate biosynthesis_Homo sapiens_hsa007900.80274101
41HTLV-I infection_Homo sapiens_hsa051660.79658888
42Herpes simplex infection_Homo sapiens_hsa051680.78682020
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75380104
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74697578
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74518194
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72796000
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.72514333
48Antigen processing and presentation_Homo sapiens_hsa046120.71539423
49Alcoholism_Homo sapiens_hsa050340.70455488
50Small cell lung cancer_Homo sapiens_hsa052220.70351814
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70203137
52Carbon metabolism_Homo sapiens_hsa012000.70167961
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68893454
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68342686
55Thyroid cancer_Homo sapiens_hsa052160.65485907
56Hippo signaling pathway_Homo sapiens_hsa043900.64757492
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60680302
58Basal cell carcinoma_Homo sapiens_hsa052170.60346838
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57451600
60Bladder cancer_Homo sapiens_hsa052190.56160369
61Sulfur relay system_Homo sapiens_hsa041220.55977862
62Fatty acid elongation_Homo sapiens_hsa000620.54567634
63Fructose and mannose metabolism_Homo sapiens_hsa000510.52916348
64Glutathione metabolism_Homo sapiens_hsa004800.50979851
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50435122
66TGF-beta signaling pathway_Homo sapiens_hsa043500.48004962
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45898406
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.45645566
69Lysine degradation_Homo sapiens_hsa003100.45539678
70Apoptosis_Homo sapiens_hsa042100.45423198
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45097164
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44093294
73Notch signaling pathway_Homo sapiens_hsa043300.43933925
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43200402
75Colorectal cancer_Homo sapiens_hsa052100.42609079
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41859357
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40374643
78Legionellosis_Homo sapiens_hsa051340.40005327
79mTOR signaling pathway_Homo sapiens_hsa041500.37983195
80Adherens junction_Homo sapiens_hsa045200.37813725
81Hedgehog signaling pathway_Homo sapiens_hsa043400.37109821
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36770016
83Chronic myeloid leukemia_Homo sapiens_hsa052200.35493782
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32612848
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31654232
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31426196
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30838580
88Pancreatic cancer_Homo sapiens_hsa052120.29882252
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29445848
90HIF-1 signaling pathway_Homo sapiens_hsa040660.28859132
91Pathways in cancer_Homo sapiens_hsa052000.27757366
92Protein export_Homo sapiens_hsa030600.26801027
93Parkinsons disease_Homo sapiens_hsa050120.26489470
94Galactose metabolism_Homo sapiens_hsa000520.26204618
95Hepatitis B_Homo sapiens_hsa051610.25655529
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24642547
97Non-small cell lung cancer_Homo sapiens_hsa052230.24020968
98Prostate cancer_Homo sapiens_hsa052150.23414214
99Glioma_Homo sapiens_hsa052140.22643745
100Tight junction_Homo sapiens_hsa045300.22234845
101AMPK signaling pathway_Homo sapiens_hsa041520.20268270
102Shigellosis_Homo sapiens_hsa051310.17812477
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16222588
104Fatty acid metabolism_Homo sapiens_hsa012120.15292900
105Melanoma_Homo sapiens_hsa052180.13234203
106Primary immunodeficiency_Homo sapiens_hsa053400.13072625
107Acute myeloid leukemia_Homo sapiens_hsa052210.12437136
108Proteoglycans in cancer_Homo sapiens_hsa052050.11930997
109Arginine and proline metabolism_Homo sapiens_hsa003300.11176245
110FoxO signaling pathway_Homo sapiens_hsa040680.10660366
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09762584
112Influenza A_Homo sapiens_hsa051640.09638563
113Viral myocarditis_Homo sapiens_hsa054160.09324139
114Endometrial cancer_Homo sapiens_hsa052130.08644183
115Metabolic pathways_Homo sapiens_hsa011000.08551420
116Huntingtons disease_Homo sapiens_hsa050160.07434687
117Wnt signaling pathway_Homo sapiens_hsa043100.07383264
118Measles_Homo sapiens_hsa051620.06767695
119Renin-angiotensin system_Homo sapiens_hsa046140.06221911

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »