CCNG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.27817482
2positive regulation of gamma-delta T cell activation (GO:0046645)5.02950333
3NIK/NF-kappaB signaling (GO:0038061)3.84685574
4regulation of gamma-delta T cell activation (GO:0046643)3.82803371
5regulation of gamma-delta T cell differentiation (GO:0045586)3.81351970
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.80615531
7negative regulation of cell killing (GO:0031342)3.80615531
8response to muramyl dipeptide (GO:0032495)3.53332884
9neutrophil activation (GO:0042119)3.42742470
10axonal fasciculation (GO:0007413)3.41527427
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41188122
12neutrophil activation involved in immune response (GO:0002283)3.40383095
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38609083
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36771976
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.36771976
16modulation by symbiont of host immune response (GO:0052553)3.36771976
17positive regulation by symbiont of host defense response (GO:0052509)3.36771976
18modulation by symbiont of host defense response (GO:0052031)3.36771976
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36771976
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34195411
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34195411
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.31848571
23natural killer cell differentiation (GO:0001779)3.31684000
24antigen processing and presentation of endogenous antigen (GO:0019883)3.29452136
25positive regulation of B cell differentiation (GO:0045579)3.29157027
26histone H3-K9 demethylation (GO:0033169)3.26197138
27granulocyte activation (GO:0036230)3.25099465
28B cell receptor signaling pathway (GO:0050853)3.15227721
29cell migration in hindbrain (GO:0021535)3.14381316
30neuron recognition (GO:0008038)3.14028627
31macrophage activation involved in immune response (GO:0002281)3.10517598
32positive regulation of interleukin-2 production (GO:0032743)3.08467166
33regulation of B cell receptor signaling pathway (GO:0050855)3.08147508
34growth hormone receptor signaling pathway (GO:0060396)3.07154711
35regulation of T-helper 1 cell differentiation (GO:0045625)3.04840311
36myeloid dendritic cell differentiation (GO:0043011)2.99583692
37positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.98890505
38myeloid dendritic cell activation (GO:0001773)2.96798623
39Peyers patch development (GO:0048541)2.96459935
40mucosal-associated lymphoid tissue development (GO:0048537)2.96459935
41pyrimidine nucleobase catabolic process (GO:0006208)2.91456536
42apical protein localization (GO:0045176)2.89570533
43histone lysine demethylation (GO:0070076)2.89158033
44regulation of T cell tolerance induction (GO:0002664)2.88634591
45central nervous system projection neuron axonogenesis (GO:0021952)2.88460569
46mature B cell differentiation (GO:0002335)2.82899583
47negative T cell selection (GO:0043383)2.81076025
48B cell homeostasis (GO:0001782)2.80917344
49regulation of B cell differentiation (GO:0045577)2.80041590
50cellular response to zinc ion (GO:0071294)2.79832247
51positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.79357025
52cerebellar granule cell differentiation (GO:0021707)2.75722145
53neuronal stem cell maintenance (GO:0097150)2.75668034
54cerebral cortex radially oriented cell migration (GO:0021799)2.75118994
55negative thymic T cell selection (GO:0045060)2.74876069
56mating behavior (GO:0007617)2.74844948
57positive regulation of natural killer cell differentiation (GO:0032825)2.73588548
58T-helper cell differentiation (GO:0042093)2.72958179
59CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.72958179
60JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.72157686
61histone demethylation (GO:0016577)2.70601775
62hepatocyte apoptotic process (GO:0097284)2.70081048
63leukocyte aggregation (GO:0070486)2.69702252
64positive regulation of interleukin-12 production (GO:0032735)2.66402315
65response to interleukin-15 (GO:0070672)2.63237991
66dendritic spine morphogenesis (GO:0060997)2.62856294
67ionotropic glutamate receptor signaling pathway (GO:0035235)2.62719351
68regulation of synaptic vesicle exocytosis (GO:2000300)2.62194500
69suckling behavior (GO:0001967)2.60496567
70regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.59103076
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.59082028
72regulation of clathrin-mediated endocytosis (GO:2000369)2.58844547
73cellular response to growth hormone stimulus (GO:0071378)2.58604320
74T cell selection (GO:0045058)2.57066141
75nerve growth factor signaling pathway (GO:0038180)2.56745159
76dendritic cell differentiation (GO:0097028)2.56120862
77positive regulation of T cell cytokine production (GO:0002726)2.55705614
78negative regulation of glial cell proliferation (GO:0060253)2.53735644
79positive regulation of T-helper cell differentiation (GO:0045624)2.53036485
80regulation of alpha-beta T cell proliferation (GO:0046640)2.52794207
81tolerance induction (GO:0002507)2.49899190
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48554447
83locomotory exploration behavior (GO:0035641)2.48525999
84myeloid cell activation involved in immune response (GO:0002275)2.48414319
85germ cell migration (GO:0008354)2.47248382
86negative regulation of neurotransmitter secretion (GO:0046929)2.47027837
87leukocyte cell-cell adhesion (GO:0007159)2.45994068
88negative regulation of interleukin-17 production (GO:0032700)2.45885613
89lymphocyte homeostasis (GO:0002260)2.45574634
90dendrite morphogenesis (GO:0048813)2.45303405
91T cell costimulation (GO:0031295)2.44828195
92positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.43894298
93regulation of memory T cell differentiation (GO:0043380)2.43832189
94germinal center formation (GO:0002467)2.43710789
95nucleobase catabolic process (GO:0046113)2.43309061
96layer formation in cerebral cortex (GO:0021819)2.43046133
97microglial cell activation (GO:0001774)2.42277637
98positive regulation of interferon-alpha production (GO:0032727)2.41832827
99lymphocyte costimulation (GO:0031294)2.40560813
100negative regulation of Rho protein signal transduction (GO:0035024)2.39658623
101serine transport (GO:0032329)2.39436240
102T cell homeostasis (GO:0043029)2.39173504
103regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.38955605
104interferon-gamma-mediated signaling pathway (GO:0060333)2.38871334
105phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.38796815
106regulation of glycogen (starch) synthase activity (GO:2000465)2.38683391
107positive regulation of alpha-beta T cell differentiation (GO:0046638)2.38660062
108regulation of ARF protein signal transduction (GO:0032012)2.38336965
109regulation of RIG-I signaling pathway (GO:0039535)2.38269356
110histone H3-K36 demethylation (GO:0070544)2.38236293
111protein dealkylation (GO:0008214)2.38114324
112protein demethylation (GO:0006482)2.38114324
113camera-type eye morphogenesis (GO:0048593)2.37378953
114establishment of tissue polarity (GO:0007164)2.37074316
115establishment of planar polarity (GO:0001736)2.37074316
116antigen receptor-mediated signaling pathway (GO:0050851)2.36984341
117response to host (GO:0075136)2.36448899
118response to host defenses (GO:0052200)2.36448899
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36448899
120positive regulation of antigen processing and presentation (GO:0002579)2.36292521
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.34495760
122central nervous system neuron axonogenesis (GO:0021955)2.34452385
123positive thymic T cell selection (GO:0045059)2.34338839
124T-helper 1 type immune response (GO:0042088)2.34021765
125cerebellar Purkinje cell differentiation (GO:0021702)2.33473013
126negative regulation of B cell proliferation (GO:0030889)2.33380468
127regulation of interleukin-17 production (GO:0032660)2.32627239
128natural killer cell activation (GO:0030101)2.31626650
129regulation of interleukin-2 biosynthetic process (GO:0045076)2.30974539
130myeloid leukocyte activation (GO:0002274)2.30717428
131T cell migration (GO:0072678)2.30359103
132response to host immune response (GO:0052572)2.30336432
133response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30336432
134cellular response to interleukin-15 (GO:0071350)2.29754677
135regulation of interferon-beta biosynthetic process (GO:0045357)2.29585436
136presynaptic membrane organization (GO:0097090)2.28911005
137response to type I interferon (GO:0034340)2.28762086
138regulation of interferon-alpha production (GO:0032647)2.28524388
139presynaptic membrane assembly (GO:0097105)2.27328034
140auditory receptor cell differentiation (GO:0042491)2.26514779
141neuron cell-cell adhesion (GO:0007158)2.26250576
142epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.25694165
143embryonic retina morphogenesis in camera-type eye (GO:0060059)2.24985335
144cellular response to catecholamine stimulus (GO:0071870)2.24724238
145cellular response to monoamine stimulus (GO:0071868)2.24724238
146limb bud formation (GO:0060174)2.22920216
147asymmetric protein localization (GO:0008105)2.22230101
148cell differentiation in hindbrain (GO:0021533)2.18353667
149Notch signaling involved in heart development (GO:0061314)2.17122040
150glutamate secretion (GO:0014047)2.16439767
151glomerulus development (GO:0032835)2.15720021
152cytoplasmic mRNA processing body assembly (GO:0033962)2.14505914
153synapse assembly (GO:0007416)2.10401313
154planar cell polarity pathway involved in neural tube closure (GO:0090179)2.09898472
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.09722199
156regulation of Rac protein signal transduction (GO:0035020)2.08838473
157peptidyl-tyrosine autophosphorylation (GO:0038083)2.08397427
158regulation of synaptic vesicle transport (GO:1902803)2.08017055
159histone H3-K9 modification (GO:0061647)2.07809932
160synaptic vesicle exocytosis (GO:0016079)2.06637023
161regulation of axon guidance (GO:1902667)2.05721566
162protein localization to synapse (GO:0035418)2.05629512
163regulation of somitogenesis (GO:0014807)2.05525329
164postsynaptic membrane organization (GO:0001941)2.04927339
165lateral sprouting from an epithelium (GO:0060601)2.04578193
166chondrocyte development (GO:0002063)2.03777071
167neural tube formation (GO:0001841)2.03565131
168forebrain neuron differentiation (GO:0021879)2.01071004
169histone H3-K4 trimethylation (GO:0080182)2.00652976
170embryonic camera-type eye morphogenesis (GO:0048596)2.00517975
171activated T cell proliferation (GO:0050798)2.00323804
172dendrite development (GO:0016358)1.99622894
173negative regulation of dendrite morphogenesis (GO:0050774)1.99156178
174establishment of nucleus localization (GO:0040023)1.98831110
175insulin-like growth factor receptor signaling pathway (GO:0048009)1.98461902
176histone H3-K9 methylation (GO:0051567)1.98233039
177adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)1.97967805
178negative regulation of type 2 immune response (GO:0002829)1.96524899
179radial glial cell differentiation (GO:0060019)1.95936403
180neuron remodeling (GO:0016322)1.95910795
181cerebral cortex cell migration (GO:0021795)1.95601979
182positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003601.95491882
183forebrain development (GO:0030900)1.95448592
184synaptic vesicle maturation (GO:0016188)1.94237316
185vesicle transport along microtubule (GO:0047496)1.92940050
186retinal ganglion cell axon guidance (GO:0031290)1.92267240
187regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.91778032
188vocalization behavior (GO:0071625)1.91686920
189telencephalon cell migration (GO:0022029)1.91511753
190glutamate receptor signaling pathway (GO:0007215)1.90126663
191calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)1.89529768
192exploration behavior (GO:0035640)1.89484450
193axon extension (GO:0048675)1.89043051
194myoblast fusion (GO:0007520)1.88326535
195negative regulation of B cell mediated immunity (GO:0002713)1.87823601
196negative regulation of immunoglobulin mediated immune response (GO:0002890)1.87823601
197membrane depolarization during cardiac muscle cell action potential (GO:0086012)1.86627111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.43181281
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.09662419
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.63804195
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.54288856
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.34134502
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.32371361
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.31779829
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95295647
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.92873444
10EZH2_22144423_ChIP-Seq_EOC_Human2.85041375
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.84886833
12RUNX_20019798_ChIP-Seq_JUKART_Human2.76752564
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64224174
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46621107
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44437014
16* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44020645
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.42512916
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32222654
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30198990
20SCL_19346495_ChIP-Seq_HPC-7_Human2.28111085
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15644280
22MYB_26560356_Chip-Seq_TH2_Human2.09045406
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02925082
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00307542
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00128395
26* TCF7_22412390_ChIP-Seq_EML_Mouse1.96602944
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90078321
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.86266430
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84277969
30VDR_24787735_ChIP-Seq_THP-1_Human1.83734881
31* FOXM1_23109430_ChIP-Seq_U2OS_Human1.82210044
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.82130883
33MAF_26560356_Chip-Seq_TH1_Human1.81947442
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.79428127
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78747736
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.76615308
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75316727
38MYC_22102868_ChIP-Seq_BL_Human1.73675213
39VDR_24763502_ChIP-Seq_THP-1_Human1.73658212
40* PIAS1_25552417_ChIP-Seq_VCAP_Human1.73619773
41VDR_21846776_ChIP-Seq_THP-1_Human1.72507372
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72281123
43AHR_22903824_ChIP-Seq_MCF-7_Human1.70716549
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70459770
45KDM2B_26808549_Chip-Seq_DND41_Human1.69311846
46* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63132799
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63008359
48MYB_26560356_Chip-Seq_TH1_Human1.60144627
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59842770
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59271477
51UTX_26944678_Chip-Seq_JUKART_Human1.57684559
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56281233
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53501088
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53501088
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.52381829
56SPI1_23127762_ChIP-Seq_K562_Human1.51941801
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49865823
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49705990
59GBX2_23144817_ChIP-Seq_PC3_Human1.47794364
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47479790
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47409038
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46161479
63GATA3_27048872_Chip-Seq_THYMUS_Human1.45515896
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45453073
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.42527915
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.39723930
67DROSHA_22980978_ChIP-Seq_HELA_Human1.39318071
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39142217
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.38722855
70* CLOCK_20551151_ChIP-Seq_293T_Human1.38235823
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37826695
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37622959
73TAF15_26573619_Chip-Seq_HEK293_Human1.37462391
74PU_27001747_Chip-Seq_BMDM_Mouse1.35855873
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34757577
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.34606395
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34348398
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.34334784
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.33961095
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33871404
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.33821867
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32862495
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30294307
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.30026199
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29944875
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29540349
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29458578
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28682679
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28280267
90RNF2_27304074_Chip-Seq_NSC_Mouse1.27092159
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26224758
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.25765444
93AR_21572438_ChIP-Seq_LNCaP_Human1.25385847
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23836920
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22590630
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22058197
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.21471306
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.20453123
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.20079624
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19867059
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19460929
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19358431
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.17156248
104REST_21632747_ChIP-Seq_MESCs_Mouse1.16429870
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16350546
106* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14852889
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14497651
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14491694
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14066166
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13428833
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13336627
112GATA1_22025678_ChIP-Seq_K562_Human1.12353573
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.12067400
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.11594890
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11543060
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11356975
117SPI1_23547873_ChIP-Seq_NB4_Human1.11045240
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10915160
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09747851
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08565836
121NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08565836
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08170658
123ELK3_25401928_ChIP-Seq_HUVEC_Human1.07826155
124* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07803758
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07311441
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06764109
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05219888
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05219888
129CDX2_20551321_ChIP-Seq_CACO-2_Human1.04865907
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04731615
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03920039
132SMAD4_21799915_ChIP-Seq_A2780_Human1.02259809
133RARB_27405468_Chip-Seq_BRAIN_Mouse0.99571786
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.98262521
135KDM2B_26808549_Chip-Seq_K562_Human0.98216154
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98085237
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97643440
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97403789
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97074243
140GATA2_19941826_ChIP-Seq_K562_Human0.96876712
141* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96385580
142* RXR_22108803_ChIP-Seq_LS180_Human0.96300735
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95698488
144* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95663635
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95586039
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94941066
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94412479
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94139500
149GATA1_19941826_ChIP-Seq_K562_Human0.93504211
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93145041
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93095271
152SMRT_27268052_Chip-Seq_Bcells_Human0.93019170
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92844058
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92818714
155TRIM28_21343339_ChIP-Seq_HEK293_Human0.92306387
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.91598804
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91116681
158EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90865193
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89637238
160* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89297486
161* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88794846
162TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88595814
163* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88305160
164FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87510970
165* TP53_16413492_ChIP-PET_HCT116_Human0.87453594
166* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87233508
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86899899
168GATA3_26560356_Chip-Seq_TH2_Human0.84570792
169ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84503240
170GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82582023
171THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82135605
172TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81721882
173CJUN_26792858_Chip-Seq_BT549_Human0.81719640
174TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81282778
175GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79983784
176MAF_26560356_Chip-Seq_TH2_Human0.78640421
177IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78528445
178KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76311465
179SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75921358
180SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75921358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.49799464
2MP0001835_abnormal_antigen_presentation3.43879967
3MP0000778_abnormal_nervous_system2.90600009
4MP0002166_altered_tumor_susceptibility2.89079715
5MP0004510_myositis2.87367621
6MP0005671_abnormal_response_to2.80670373
7MP0001800_abnormal_humoral_immune2.79736708
8MP0005387_immune_system_phenotype2.78202090
9MP0001790_abnormal_immune_system2.78202090
10MP0000569_abnormal_digit_pigmentation2.76810622
11MP0004859_abnormal_synaptic_plasticity2.75978222
12MP0009785_altered_susceptibility_to2.75078541
13MP0005248_abnormal_Harderian_gland2.73458833
14MP0002452_abnormal_antigen_presenting2.64932312
15MP0005000_abnormal_immune_tolerance2.64293231
16MP0003303_peritoneal_inflammation2.62460929
17MP0003436_decreased_susceptibility_to2.59893536
18MP0002006_tumorigenesis2.58673811
19MP0003880_abnormal_central_pattern2.42851102
20MP0001819_abnormal_immune_cell2.39739060
21MP0002723_abnormal_immune_serum2.39578157
22MP0002420_abnormal_adaptive_immunity2.37837006
23MP0003300_gastrointestinal_ulcer2.37286620
24MP0002148_abnormal_hypersensitivity_rea2.36313794
25MP0004270_analgesia2.35737530
26MP0006054_spinal_hemorrhage2.29901865
27MP0004858_abnormal_nervous_system2.28145822
28MP0002419_abnormal_innate_immunity2.24507861
29MP0000566_synostosis2.22739549
30MP0003122_maternal_imprinting2.22376770
31MP0005409_darkened_coat_color2.20475428
32MP0004885_abnormal_endolymph2.14936964
33MP0010155_abnormal_intestine_physiology2.12571308
34MP0005025_abnormal_response_to2.11900622
35MP0002254_reproductive_system_inflammat2.11682463
36MP0002009_preneoplasia2.05797434
37MP0002398_abnormal_bone_marrow2.03390627
38MP0004947_skin_inflammation2.02976973
39MP0010234_abnormal_vibrissa_follicle1.99600423
40MP0000716_abnormal_immune_system1.91152114
41MP0002653_abnormal_ependyma_morphology1.88131031
42MP0003183_abnormal_peptide_metabolism1.82966737
43MP0005076_abnormal_cell_differentiation1.81691937
44MP0002822_catalepsy1.77095777
45MP0001879_abnormal_lymphatic_vessel1.75373096
46MP0003938_abnormal_ear_development1.71295330
47MP0004381_abnormal_hair_follicle1.71035014
48MP0005464_abnormal_platelet_physiology1.70317944
49MP0005423_abnormal_somatic_nervous1.68106143
50MP0009278_abnormal_bone_marrow1.68007600
51MP0006082_CNS_inflammation1.66424742
52MP0003635_abnormal_synaptic_transmissio1.65127673
53MP0003763_abnormal_thymus_physiology1.62812213
54MP0005275_abnormal_skin_tensile1.60815360
55MP0001873_stomach_inflammation1.57280380
56MP0000537_abnormal_urethra_morphology1.55073597
57MP0002063_abnormal_learning/memory/cond1.52923098
58MP0002405_respiratory_system_inflammati1.51915951
59MP0003121_genomic_imprinting1.50997146
60MP0000955_abnormal_spinal_cord1.50004575
61MP0002429_abnormal_blood_cell1.46943439
62MP0001533_abnormal_skeleton_physiology1.46405791
63MP0002138_abnormal_hepatobiliary_system1.45923649
64MP0000703_abnormal_thymus_morphology1.44434387
65MP0003123_paternal_imprinting1.44369225
66MP0005310_abnormal_salivary_gland1.43793687
67MP0002722_abnormal_immune_system1.43657629
68MP0003448_altered_tumor_morphology1.41911828
69MP0004185_abnormal_adipocyte_glucose1.41141830
70MP0001845_abnormal_inflammatory_respons1.40471428
71MP0001188_hyperpigmentation1.40049962
72MP0003453_abnormal_keratinocyte_physiol1.38717441
73MP0000534_abnormal_ureter_morphology1.35405632
74MP0000689_abnormal_spleen_morphology1.35137794
75MP0001958_emphysema1.34428672
76MP0002998_abnormal_bone_remodeling1.34280511
77MP0001502_abnormal_circadian_rhythm1.32209283
78MP0002234_abnormal_pharynx_morphology1.31129499
79MP0004808_abnormal_hematopoietic_stem1.31127428
80MP0005394_taste/olfaction_phenotype1.29220585
81MP0005499_abnormal_olfactory_system1.29220585
82MP0003091_abnormal_cell_migration1.28306771
83MP0003866_abnormal_defecation1.27322830
84MP0003705_abnormal_hypodermis_morpholog1.26972520
85MP0010352_gastrointestinal_tract_polyps1.25781354
86MP0002184_abnormal_innervation1.24862317
87MP0005397_hematopoietic_system_phenotyp1.24769578
88MP0001545_abnormal_hematopoietic_system1.24769578
89MP0001486_abnormal_startle_reflex1.23398199
90MP0002909_abnormal_adrenal_gland1.22407007
91MP0004264_abnormal_extraembryonic_tissu1.20796996
92MP0005174_abnormal_tail_pigmentation1.20331299
93MP0005377_hearing/vestibular/ear_phenot1.18920694
94MP0003878_abnormal_ear_physiology1.18920694
95MP0001851_eye_inflammation1.18760829
96MP0003724_increased_susceptibility_to1.18085437
97MP0000465_gastrointestinal_hemorrhage1.17109173
98MP0002735_abnormal_chemical_nociception1.16358493
99MP0001853_heart_inflammation1.15759306
100MP0002933_joint_inflammation1.14040537
101MP0003942_abnormal_urinary_system1.12850569
102MP0002152_abnormal_brain_morphology1.12225768
103MP0003890_abnormal_embryonic-extraembry1.11882480
104MP0002877_abnormal_melanocyte_morpholog1.11006149
105MP0003315_abnormal_perineum_morphology1.10453511
106MP0003191_abnormal_cellular_cholesterol1.09335374
107MP0000858_altered_metastatic_potential1.08533545
108MP0010030_abnormal_orbit_morphology1.08227443
109MP0008789_abnormal_olfactory_epithelium1.07119351
110MP0003755_abnormal_palate_morphology1.06777460
111MP0003045_fibrosis1.06343708
112MP0002882_abnormal_neuron_morphology1.05533492
113MP0002396_abnormal_hematopoietic_system1.05439921
114MP0004811_abnormal_neuron_physiology1.04849948
115MP0005167_abnormal_blood-brain_barrier1.04845433
116MP0003861_abnormal_nervous_system1.04192479
117MP0005503_abnormal_tendon_morphology1.02677929
118MP0008569_lethality_at_weaning1.02669716
119MP0000631_abnormal_neuroendocrine_gland1.02259455
120MP0002557_abnormal_social/conspecific_i1.01806861
121MP0005187_abnormal_penis_morphology1.01433935
122MP0005367_renal/urinary_system_phenotyp1.00956874
123MP0000516_abnormal_urinary_system1.00956874
124MP0002277_abnormal_respiratory_mucosa1.00902017
125MP0002734_abnormal_mechanical_nocicepti1.00458176
126MP0001348_abnormal_lacrimal_gland0.98031517
127MP0009379_abnormal_foot_pigmentation0.97923251
128MP0002572_abnormal_emotion/affect_behav0.97098429
129MP0002928_abnormal_bile_duct0.97063159
130MP0003787_abnormal_imprinting0.96841517
131MP0009764_decreased_sensitivity_to0.95618428
132MP0000733_abnormal_muscle_development0.94417584
133MP0002249_abnormal_larynx_morphology0.94371103
134MP0000026_abnormal_inner_ear0.94268080
135MP0000383_abnormal_hair_follicle0.91213454
136MP0008961_abnormal_basal_metabolism0.91105723
137MP0003115_abnormal_respiratory_system0.91067415
138MP0005058_abnormal_lysosome_morphology0.90854899
139MP0000762_abnormal_tongue_morphology0.90641342
140MP0001286_abnormal_eye_development0.90056070
141MP0001485_abnormal_pinna_reflex0.89895181
142MP0001849_ear_inflammation0.89573956
143MP0002064_seizures0.89481369
144MP0002116_abnormal_craniofacial_bone0.88980870
145MP0002233_abnormal_nose_morphology0.88414997
146MP0003935_abnormal_craniofacial_develop0.87989993
147MP0004043_abnormal_pH_regulation0.87808486
148MP0005166_decreased_susceptibility_to0.87724068
149MP0004742_abnormal_vestibular_system0.86226812
150MP0002067_abnormal_sensory_capabilities0.85607538
151MP0009333_abnormal_splenocyte_physiolog0.85279026
152MP0000249_abnormal_blood_vessel0.83558242
153MP0000377_abnormal_hair_follicle0.82795680
154MP0001440_abnormal_grooming_behavior0.82502241
155MP0000049_abnormal_middle_ear0.82185577
156MP0008469_abnormal_protein_level0.81408904
157MP0004130_abnormal_muscle_cell0.81299684
158MP0010678_abnormal_skin_adnexa0.80948323
159MP0000767_abnormal_smooth_muscle0.80117605
160MP0003075_altered_response_to0.79890439
161MP0002098_abnormal_vibrissa_morphology0.77487718
162MP0001346_abnormal_lacrimal_gland0.76396557
163MP0002752_abnormal_somatic_nervous0.75943092
164MP0003119_abnormal_digestive_system0.75380202
165MP0000490_abnormal_crypts_of0.74978140
166MP0003329_amyloid_beta_deposits0.74315286
167MP0002108_abnormal_muscle_morphology0.73829192
168MP0009745_abnormal_behavioral_response0.73821122
169MP0002081_perinatal_lethality0.73750771
170MP0002751_abnormal_autonomic_nervous0.72921090
171MP0005666_abnormal_adipose_tissue0.72420870
172MP0000343_altered_response_to0.72329642
173MP0003632_abnormal_nervous_system0.72110401
174MP0002896_abnormal_bone_mineralization0.72028879
175MP0003828_pulmonary_edema0.70365145
176MP0000604_amyloidosis0.68416580
177MP0000920_abnormal_myelination0.65160828
178MP0001663_abnormal_digestive_system0.64414893
179MP0005390_skeleton_phenotype0.59846220
180MP0003795_abnormal_bone_structure0.58384426
181MP0005164_abnormal_response_to0.58271328
182MP0002971_abnormal_brown_adipose0.57951740
183MP0002925_abnormal_cardiovascular_devel0.57096426
184MP0000477_abnormal_intestine_morphology0.55980476
185MP0000015_abnormal_ear_pigmentation0.54848348

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)4.00806036
2Recurrent fungal infections (HP:0002841)3.98010902
3Recurrent abscess formation (HP:0002722)3.97704605
4Thyroiditis (HP:0100646)3.91057486
5Eczematoid dermatitis (HP:0000976)3.85454425
6Myositis (HP:0100614)3.78034157
7Recurrent bacterial skin infections (HP:0005406)3.76271293
8Optic neuritis (HP:0100653)3.56187763
9Retrobulbar optic neuritis (HP:0100654)3.56187763
10Orchitis (HP:0100796)3.45741948
11B lymphocytopenia (HP:0010976)3.25443132
12Abnormality of B cell number (HP:0010975)3.25443132
13Hematochezia (HP:0002573)3.23936095
14Cellulitis (HP:0100658)3.22385442
15Elevated erythrocyte sedimentation rate (HP:0003565)3.20729231
16Papillary thyroid carcinoma (HP:0002895)3.14790052
17Mediastinal lymphadenopathy (HP:0100721)3.11904211
18Agammaglobulinemia (HP:0004432)3.03497331
19Colitis (HP:0002583)3.03194687
20Panhypogammaglobulinemia (HP:0003139)2.97197719
21Severe combined immunodeficiency (HP:0004430)2.91986841
22Curly hair (HP:0002212)2.91186923
23Chronic otitis media (HP:0000389)2.90278557
24T lymphocytopenia (HP:0005403)2.87520892
25Arterial tortuosity (HP:0005116)2.86917069
26Disinhibition (HP:0000734)2.86202943
27Abnormality of T cell number (HP:0011839)2.86086679
28Vasculitis (HP:0002633)2.82432706
29Chronic mucocutaneous candidiasis (HP:0002728)2.79229925
30Recurrent cutaneous fungal infections (HP:0011370)2.79229925
31Recurrent skin infections (HP:0001581)2.75533553
32Overgrowth (HP:0001548)2.71246490
33Gastrointestinal stroma tumor (HP:0100723)2.70396840
34Abnormality of the fingertips (HP:0001211)2.69919161
35Verrucae (HP:0200043)2.69173517
36Papilloma (HP:0012740)2.69173517
37Eosinophilia (HP:0001880)2.63579359
38Abnormality of macrophages (HP:0004311)2.62811447
39Vascular tortuosity (HP:0004948)2.58905474
40Inflammation of the large intestine (HP:0002037)2.58262103
41Leukocytosis (HP:0001974)2.57572142
42Meningitis (HP:0001287)2.57549903
43Fatigue (HP:0012378)2.56257180
44Combined immunodeficiency (HP:0005387)2.55909546
45Neonatal short-limb short stature (HP:0008921)2.53674895
46Autoimmune thrombocytopenia (HP:0001973)2.53667675
47Pulmonary infiltrates (HP:0002113)2.53239564
48Papilledema (HP:0001085)2.52962676
49Aortic aneurysm (HP:0004942)2.52463071
50Abnormality of eosinophils (HP:0001879)2.52285030
51Gastrointestinal inflammation (HP:0004386)2.47121428
52Recurrent gram-negative bacterial infections (HP:0005420)2.46637203
53Germ cell neoplasia (HP:0100728)2.45826356
54Recurrent bronchitis (HP:0002837)2.45196803
55Neoplasm of the heart (HP:0100544)2.43315007
56Increased IgE level (HP:0003212)2.42037414
57Obstructive sleep apnea (HP:0002870)2.40635565
58Osteomyelitis (HP:0002754)2.40403777
59Arterial thrombosis (HP:0004420)2.39467617
60Keratoconjunctivitis sicca (HP:0001097)2.38103005
61Persistence of primary teeth (HP:0006335)2.35192137
62Chronic diarrhea (HP:0002028)2.31614646
63Subacute progressive viral hepatitis (HP:0006572)2.28806136
64Interstitial pulmonary disease (HP:0006530)2.28218469
65Increased density of long bones (HP:0006392)2.25596696
66Keratoconjunctivitis (HP:0001096)2.23812285
67Cystic hygroma (HP:0000476)2.23266395
68Febrile seizures (HP:0002373)2.21181651
69Vitreoretinal degeneration (HP:0000655)2.20045336
70Viral hepatitis (HP:0006562)2.18300197
71Neonatal hypoglycemia (HP:0001998)2.16097633
72Lip pit (HP:0100267)2.15758208
73Abnormality of incisor morphology (HP:0011063)2.15108826
74Vertebral arch anomaly (HP:0008438)2.14268200
75Lymphopenia (HP:0001888)2.13946899
76Abnormality of the ischium (HP:0003174)2.13341429
77Gingivitis (HP:0000230)2.13073600
78Hepatoblastoma (HP:0002884)2.12891260
79Inappropriate behavior (HP:0000719)2.10961375
80Neurofibrillary tangles (HP:0002185)2.09454664
81Granulocytopenia (HP:0001913)2.08200392
82Hemoptysis (HP:0002105)2.08113086
83Genetic anticipation (HP:0003743)2.07566861
84Peritonitis (HP:0002586)2.07408425
85Cerebral aneurysm (HP:0004944)2.06935586
86Abnormality of the parietal bone (HP:0002696)2.06897031
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.06626443
88Action tremor (HP:0002345)2.05186879
89Increased cerebral lipofuscin (HP:0011813)2.03998407
90Morphological abnormality of the middle ear (HP:0008609)2.03633355
91Tetraparesis (HP:0002273)2.03095113
92Hypoplastic ischia (HP:0003175)2.01480982
93Short 4th metacarpal (HP:0010044)2.00856619
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00856619
95Abnormality of the corticospinal tract (HP:0002492)1.98516251
96Sepsis (HP:0100806)1.96285312
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.95771848
98Thyroid carcinoma (HP:0002890)1.95204189
99Spontaneous hematomas (HP:0007420)1.94681948
100Autoimmune hemolytic anemia (HP:0001890)1.93540253
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.92212888
102Bicuspid aortic valve (HP:0001647)1.90655354
103Emphysema (HP:0002097)1.90345875
104Septo-optic dysplasia (HP:0100842)1.89972624
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89262979
106Striae distensae (HP:0001065)1.87307831
107Periodontitis (HP:0000704)1.85713560
108Pustule (HP:0200039)1.85603816
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.83828333
110Recurrent pneumonia (HP:0006532)1.82330372
111Spondylolisthesis (HP:0003302)1.82121306
112Hamartoma (HP:0010566)1.80789792
113Abnormality of T cells (HP:0002843)1.80721568
114Atonic seizures (HP:0010819)1.80007403
115Aortic dissection (HP:0002647)1.79782946
116Hypergammaglobulinemia (HP:0010702)1.79644041
117Atrophic scars (HP:0001075)1.79084359
118Epileptic encephalopathy (HP:0200134)1.78660070
119Stomatitis (HP:0010280)1.78472890
120Progressive cerebellar ataxia (HP:0002073)1.78300333
121Megalencephaly (HP:0001355)1.77609073
122Thick nail (HP:0001805)1.77172629
123Absent frontal sinuses (HP:0002688)1.76512783
124Mitral valve prolapse (HP:0001634)1.76403866
125Narrow palate (HP:0000189)1.75831438
126Excessive salivation (HP:0003781)1.75591413
127Gastrointestinal infarctions (HP:0005244)1.73252647
128Ankle clonus (HP:0011448)1.73054609
129Thickened calvaria (HP:0002684)1.72705524
130Macroorchidism (HP:0000053)1.71960958
131Encephalitis (HP:0002383)1.71064688
132Drooling (HP:0002307)1.70424418
133Chronic sinusitis (HP:0011109)1.70310870
134Abnormality of the pubic bones (HP:0003172)1.69980969
135Abnormality of the lower motor neuron (HP:0002366)1.69754671
136Dilatation of the ascending aorta (HP:0005111)1.69298292
137Large earlobe (HP:0009748)1.69026437
138Cortical dysplasia (HP:0002539)1.68586452
139Diminished motivation (HP:0000745)1.68471510
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.68214019
141Broad nasal tip (HP:0000455)1.68037710
142Depressed nasal tip (HP:0000437)1.67767466
143Recurrent lower respiratory tract infections (HP:0002783)1.67185641
144Cubitus valgus (HP:0002967)1.66943034
145Tapered finger (HP:0001182)1.66577446
146Midline defect of the nose (HP:0004122)1.66380504
147Fetal akinesia sequence (HP:0001989)1.66104227
148Hip dysplasia (HP:0001385)1.66032275
149Exotropia (HP:0000577)1.65780293
150Wide anterior fontanel (HP:0000260)1.65364936
151Chest pain (HP:0100749)1.65277072
152Transitional cell carcinoma of the bladder (HP:0006740)1.64243982
153Thin bony cortex (HP:0002753)1.64110191
154Hypoproteinemia (HP:0003075)1.64030975
155Exostoses (HP:0100777)1.63811506
156Tented upper lip vermilion (HP:0010804)1.63470167
157Amyotrophic lateral sclerosis (HP:0007354)1.62663454
158Absent speech (HP:0001344)1.62356301
159Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62080263
160Degeneration of the lateral corticospinal tracts (HP:0002314)1.62080263
161Milia (HP:0001056)1.62039606
162Aqueductal stenosis (HP:0002410)1.61893792
163Truncal obesity (HP:0001956)1.61779899
164Hyperventilation (HP:0002883)1.61179187
165Bladder carcinoma (HP:0002862)1.60177756
166Bladder neoplasm (HP:0009725)1.60177756
167Shawl scrotum (HP:0000049)1.59696660
168Broad metatarsal (HP:0001783)1.59307664
169Abnormality of the axillary hair (HP:0100134)1.58256189
170Abnormality of secondary sexual hair (HP:0009888)1.58256189
171Broad palm (HP:0001169)1.57676671
172Focal seizures (HP:0007359)1.56550255
173Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.56341135
174Testicular neoplasm (HP:0010788)1.55430514
175Cerebral inclusion bodies (HP:0100314)1.55197305
176Hypoplasia of the iris (HP:0007676)1.54735328
177Sporadic (HP:0003745)1.54517997
178Supernumerary ribs (HP:0005815)1.52677635
179Abnormal hair whorl (HP:0010721)1.52277060
180Hemiplegia (HP:0002301)1.50705302
181Bronchomalacia (HP:0002780)1.49934699
182Buphthalmos (HP:0000557)1.49712887
183Hypoplastic nipples (HP:0002557)1.49054609
184Sleep apnea (HP:0010535)1.47896549
185Anterior segment dysgenesis (HP:0007700)1.47465475
186Absent eyebrow (HP:0002223)1.47139180
187Asymmetry of the thorax (HP:0001555)1.47110163
188Thickened nuchal skin fold (HP:0000474)1.46605492
189Hyperextensible skin (HP:0000974)1.45750505
190Hyperactive renin-angiotensin system (HP:0000841)1.45624854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.87163999
2MAP3K143.13587397
3RIPK42.98776677
4CASK2.80832235
5AKT32.72041946
6TYK22.71833255
7MARK12.51429498
8TBK12.42163513
9MAP3K132.39473126
10SGK22.37612346
11MAP4K12.31412992
12TGFBR22.28376988
13BRD42.22514530
14JAK32.19039634
15GRK62.17018812
16JAK12.10623648
17SGK4942.03786269
18SGK2232.03786269
19EPHB12.00271310
20KIT1.80307842
21IKBKE1.79887241
22PTK61.77937141
23SIK21.71657978
24STK101.68649640
25ITK1.66111160
26LATS11.65639722
27IKBKB1.65192173
28TXK1.62184410
29CSF1R1.56574343
30EEF2K1.54470685
31FGFR31.49894862
32CHUK1.46779884
33NTRK21.43952309
34CDK191.42673821
35SYK1.42257668
36PRKD31.36688569
37HCK1.34085646
38RIPK11.32721747
39TRIB31.31721784
40MAP2K41.31657658
41BTK1.31623208
42MARK21.31497138
43IRAK41.31334794
44WNK11.27857554
45SIK11.27174409
46MELK1.23195293
47PKN21.22740134
48LATS21.17464940
49MAP3K91.16267832
50DYRK1B1.14713010
51FGR1.14343462
52CDK61.14231333
53DMPK1.14177406
54CDK91.11208874
55TNK21.10174110
56EPHA31.10150394
57CAMKK11.09667051
58RET1.09591699
59LRRK21.09288162
60BCR1.08666525
61PIK3CA1.06976058
62LCK1.06350120
63NTRK31.03976998
64CLK11.02658468
65PDGFRB0.99703304
66DAPK20.99322277
67UHMK10.99088100
68FRK0.98174579
69MST40.97896603
70JAK20.97847075
71NTRK10.94907071
72FGFR40.94078072
73ERBB20.93525786
74SIK30.92743562
75FGFR20.92132169
76KSR20.91813436
77IRAK10.90902708
78STK240.90698961
79IRAK20.90160364
80ERBB30.89384379
81TNIK0.88505545
82FLT30.87882057
83CSK0.87011766
84MARK30.86690222
85RPS6KA20.85406059
86DYRK1A0.84867392
87ZAP700.84689985
88CAMKK20.84259660
89TAOK30.83497002
90STK380.82655536
91OXSR10.81898450
92FES0.81297617
93PRKCQ0.81215549
94RPS6KA40.81138758
95STK40.80947537
96PAK30.80871201
97NUAK10.80511239
98EPHB20.79835882
99PRPF4B0.79625284
100MAP3K40.79417763
101TEC0.78901233
102PIM10.78099027
103STK390.77344325
104KSR10.77160386
105STK30.76949214
106FER0.74717843
107CDK50.74087237
108TAOK10.73592724
109NLK0.73123787
110CDK120.69761205
111LYN0.69439587
112PRKD20.68217677
113ERN10.67569865
114PRKCZ0.66679130
115CAMK1D0.66556367
116MAPK70.66179827
117MATK0.66030104
118MAP2K70.65727179
119SCYL20.65574203
120STK38L0.65067033
121MAP3K70.63577784
122HIPK20.62825249
123RPS6KL10.59251538
124RPS6KC10.59251538
125MAP3K20.58157300
126MINK10.57725631
127YES10.56932708
128PRKAA20.56564481
129PAK60.55827789
130ABL10.54724673
131MAPKAPK20.54232316
132RPS6KA60.54145316
133TYRO30.53722835
134NEK20.53680542
135RPS6KB10.53173625
136TGFBR10.51665608
137STK110.51604040
138BLK0.50945233
139BMPR20.50090514
140PRKCH0.49522664
141TRPM70.47049636
142CAMK40.46263995
143FYN0.45461387
144PDGFRA0.45448986
145DYRK30.45018185
146EGFR0.44794771
147EPHA40.43499003
148CAMK1G0.43099104
149MAPK130.42640137
150BMX0.42249116
151INSR0.41545717
152SGK30.41373540
153PKN10.38938366
154MAP3K60.36572866
155SGK10.33609987

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.34817145
2Leishmaniasis_Homo sapiens_hsa051402.33842851
3B cell receptor signaling pathway_Homo sapiens_hsa046622.19369199
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.11698215
5Primary immunodeficiency_Homo sapiens_hsa053401.98072893
6T cell receptor signaling pathway_Homo sapiens_hsa046601.73132784
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71833995
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71275569
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.69204606
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68864285
11Measles_Homo sapiens_hsa051621.67704615
12Toxoplasmosis_Homo sapiens_hsa051451.67606670
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67354569
14TNF signaling pathway_Homo sapiens_hsa046681.66100321
15Nicotine addiction_Homo sapiens_hsa050331.53162015
16Chronic myeloid leukemia_Homo sapiens_hsa052201.52947597
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47336766
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46328893
19Long-term potentiation_Homo sapiens_hsa047201.46158505
20Chemokine signaling pathway_Homo sapiens_hsa040621.44954300
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40933811
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40545362
23Tuberculosis_Homo sapiens_hsa051521.36903017
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36530139
25Pancreatic cancer_Homo sapiens_hsa052121.36372551
26Hematopoietic cell lineage_Homo sapiens_hsa046401.33367442
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30947075
28Dopaminergic synapse_Homo sapiens_hsa047281.30842319
29Long-term depression_Homo sapiens_hsa047301.30272254
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.27916577
31Graft-versus-host disease_Homo sapiens_hsa053321.27319905
32Influenza A_Homo sapiens_hsa051641.25056203
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24910283
34Glutamatergic synapse_Homo sapiens_hsa047241.24137124
35Pertussis_Homo sapiens_hsa051331.23651903
36Cocaine addiction_Homo sapiens_hsa050301.23567869
37Circadian entrainment_Homo sapiens_hsa047131.21588282
38Allograft rejection_Homo sapiens_hsa053301.20311428
39Hepatitis B_Homo sapiens_hsa051611.20003653
40Shigellosis_Homo sapiens_hsa051311.19755848
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.17280105
42Colorectal cancer_Homo sapiens_hsa052101.17191151
43Apoptosis_Homo sapiens_hsa042101.14949373
44Platelet activation_Homo sapiens_hsa046111.14502343
45Amphetamine addiction_Homo sapiens_hsa050311.14172735
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13188511
47Hedgehog signaling pathway_Homo sapiens_hsa043401.13039699
48Salmonella infection_Homo sapiens_hsa051321.10140757
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.08905226
50Circadian rhythm_Homo sapiens_hsa047101.08099522
51Viral myocarditis_Homo sapiens_hsa054161.07735130
52Acute myeloid leukemia_Homo sapiens_hsa052211.07607309
53VEGF signaling pathway_Homo sapiens_hsa043701.06995691
54Legionellosis_Homo sapiens_hsa051341.05620471
55Small cell lung cancer_Homo sapiens_hsa052221.05228691
56Melanogenesis_Homo sapiens_hsa049161.04675486
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01790475
58Herpes simplex infection_Homo sapiens_hsa051681.01672195
59Morphine addiction_Homo sapiens_hsa050321.00923072
60Gap junction_Homo sapiens_hsa045400.99276539
61Antigen processing and presentation_Homo sapiens_hsa046120.98403735
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98024988
63African trypanosomiasis_Homo sapiens_hsa051430.97744002
64Prolactin signaling pathway_Homo sapiens_hsa049170.96571706
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95842457
66Renal cell carcinoma_Homo sapiens_hsa052110.95114375
67GABAergic synapse_Homo sapiens_hsa047270.94420804
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94198434
69Malaria_Homo sapiens_hsa051440.94068928
70Basal cell carcinoma_Homo sapiens_hsa052170.93221635
71Inositol phosphate metabolism_Homo sapiens_hsa005620.91784967
72Oxytocin signaling pathway_Homo sapiens_hsa049210.91685763
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91498692
74Non-small cell lung cancer_Homo sapiens_hsa052230.91305515
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90875179
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89844795
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89715332
78cAMP signaling pathway_Homo sapiens_hsa040240.88462259
79Ras signaling pathway_Homo sapiens_hsa040140.88444295
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88222085
81MicroRNAs in cancer_Homo sapiens_hsa052060.87408447
82Hepatitis C_Homo sapiens_hsa051600.86501854
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85776652
84Type II diabetes mellitus_Homo sapiens_hsa049300.84900629
85Serotonergic synapse_Homo sapiens_hsa047260.84851359
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83737521
87AMPK signaling pathway_Homo sapiens_hsa041520.82985240
88Endometrial cancer_Homo sapiens_hsa052130.82348507
89Proteoglycans in cancer_Homo sapiens_hsa052050.80406386
90* FoxO signaling pathway_Homo sapiens_hsa040680.78236809
91Glioma_Homo sapiens_hsa052140.77871651
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.77365273
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77185401
94Insulin resistance_Homo sapiens_hsa049310.77086806
95Hippo signaling pathway_Homo sapiens_hsa043900.76782412
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76159375
97MAPK signaling pathway_Homo sapiens_hsa040100.75987252
98mTOR signaling pathway_Homo sapiens_hsa041500.75866109
99Wnt signaling pathway_Homo sapiens_hsa043100.75359657
100Amoebiasis_Homo sapiens_hsa051460.75109826
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75062764
102Rheumatoid arthritis_Homo sapiens_hsa053230.74918396
103Insulin signaling pathway_Homo sapiens_hsa049100.74711423
104Viral carcinogenesis_Homo sapiens_hsa052030.74475177
105Synaptic vesicle cycle_Homo sapiens_hsa047210.74374688
106Gastric acid secretion_Homo sapiens_hsa049710.74183669
107Taste transduction_Homo sapiens_hsa047420.73141455
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72981431
109Adherens junction_Homo sapiens_hsa045200.72444557
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.71799563
111Thyroid cancer_Homo sapiens_hsa052160.71405637
112Dorso-ventral axis formation_Homo sapiens_hsa043200.70906382
113Choline metabolism in cancer_Homo sapiens_hsa052310.70890233
114Endocytosis_Homo sapiens_hsa041440.70868973
115Salivary secretion_Homo sapiens_hsa049700.69791499
116Prostate cancer_Homo sapiens_hsa052150.68059762
117Focal adhesion_Homo sapiens_hsa045100.68019939
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.67823652
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67256647
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66947658
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66786530
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66452739
123HTLV-I infection_Homo sapiens_hsa051660.66179888
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65472455
125ErbB signaling pathway_Homo sapiens_hsa040120.64838219
126Renin secretion_Homo sapiens_hsa049240.64597720
127Axon guidance_Homo sapiens_hsa043600.63090972
128Insulin secretion_Homo sapiens_hsa049110.62860199
129Protein digestion and absorption_Homo sapiens_hsa049740.62178589
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62172740
131Staphylococcus aureus infection_Homo sapiens_hsa051500.61728865
132Alcoholism_Homo sapiens_hsa050340.60358654
133Estrogen signaling pathway_Homo sapiens_hsa049150.59285743
134Autoimmune thyroid disease_Homo sapiens_hsa053200.59206231
135Rap1 signaling pathway_Homo sapiens_hsa040150.58626585
136GnRH signaling pathway_Homo sapiens_hsa049120.57653493
137Type I diabetes mellitus_Homo sapiens_hsa049400.55442526
138Notch signaling pathway_Homo sapiens_hsa043300.55184008
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54923869
140Pathways in cancer_Homo sapiens_hsa052000.54315819
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53709390
142HIF-1 signaling pathway_Homo sapiens_hsa040660.49843026
143Cholinergic synapse_Homo sapiens_hsa047250.48514022

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