CCNH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76203309
2cullin deneddylation (GO:0010388)4.74103484
3protein deneddylation (GO:0000338)4.56412486
4chaperone-mediated protein transport (GO:0072321)4.52849595
5protein complex biogenesis (GO:0070271)4.52393657
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.50788874
7NADH dehydrogenase complex assembly (GO:0010257)4.50788874
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.50788874
9exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.42265679
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33224617
11ATP synthesis coupled proton transport (GO:0015986)4.33224617
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.29049858
13proteasome assembly (GO:0043248)4.28139589
14mitochondrial respiratory chain complex assembly (GO:0033108)4.18650435
15DNA deamination (GO:0045006)4.00431152
16RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.97456327
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83965139
18termination of RNA polymerase III transcription (GO:0006386)3.76611531
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.76611531
20regulation of mitotic spindle checkpoint (GO:1903504)3.75471087
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.75471087
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74222663
23regulation of mitochondrial translation (GO:0070129)3.67243386
24negative regulation of mast cell activation (GO:0033004)3.66647763
25telomere maintenance via semi-conservative replication (GO:0032201)3.58799052
26* 7-methylguanosine mRNA capping (GO:0006370)3.58128248
27respiratory chain complex IV assembly (GO:0008535)3.57868685
28establishment of integrated proviral latency (GO:0075713)3.53361542
29* RNA capping (GO:0036260)3.52483406
30* 7-methylguanosine RNA capping (GO:0009452)3.52483406
31preassembly of GPI anchor in ER membrane (GO:0016254)3.51043783
32purine nucleobase biosynthetic process (GO:0009113)3.50407759
33respiratory electron transport chain (GO:0022904)3.49560037
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48032185
35nucleobase biosynthetic process (GO:0046112)3.47948707
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.46939876
37protein neddylation (GO:0045116)3.45202030
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43403192
39regulation of cellular amino acid metabolic process (GO:0006521)3.43334792
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42472950
41protein-cofactor linkage (GO:0018065)3.42116957
42electron transport chain (GO:0022900)3.41401078
43oxidative phosphorylation (GO:0006119)3.41308674
44DNA strand elongation involved in DNA replication (GO:0006271)3.41110409
45mannosylation (GO:0097502)3.41034451
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40351890
47negative regulation of ligase activity (GO:0051352)3.40351890
48peptidyl-histidine modification (GO:0018202)3.40323922
49pseudouridine synthesis (GO:0001522)3.35912024
50metallo-sulfur cluster assembly (GO:0031163)3.35154740
51iron-sulfur cluster assembly (GO:0016226)3.35154740
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35146238
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31285364
54DNA strand elongation (GO:0022616)3.30294623
55cytochrome complex assembly (GO:0017004)3.29452444
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29281836
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29281836
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27021226
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27021226
60organelle disassembly (GO:1903008)3.26804100
61telomere maintenance via recombination (GO:0000722)3.26226912
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25232073
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25232073
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25232073
65neural tube formation (GO:0001841)3.23990894
66amino acid salvage (GO:0043102)3.23516385
67L-methionine salvage (GO:0071267)3.23516385
68L-methionine biosynthetic process (GO:0071265)3.23516385
69DNA replication initiation (GO:0006270)3.22067253
70guanosine-containing compound biosynthetic process (GO:1901070)3.22000054
71CENP-A containing nucleosome assembly (GO:0034080)3.21932950
72ribosomal small subunit assembly (GO:0000028)3.19613705
73centriole replication (GO:0007099)3.19567555
74dopamine transport (GO:0015872)3.19343688
75maturation of 5.8S rRNA (GO:0000460)3.18462123
76viral mRNA export from host cell nucleus (GO:0046784)3.18326642
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.17006566
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.17006566
79isotype switching (GO:0045190)3.17006566
80protein targeting to mitochondrion (GO:0006626)3.16421382
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.11431861
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11431861
832-deoxyribonucleotide biosynthetic process (GO:0009265)3.11287017
84deoxyribose phosphate biosynthetic process (GO:0046385)3.11287017
85signal transduction involved in cell cycle checkpoint (GO:0072395)3.08890010
86establishment of protein localization to mitochondrion (GO:0072655)3.08432696
87signal peptide processing (GO:0006465)3.06416945
88DNA replication checkpoint (GO:0000076)3.04636276
89chromatin remodeling at centromere (GO:0031055)3.04510616
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04354710
91GPI anchor metabolic process (GO:0006505)3.02433413
92establishment of viral latency (GO:0019043)3.01206754
93GTP biosynthetic process (GO:0006183)2.99762041
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.97845464
95positive regulation of mRNA catabolic process (GO:0061014)2.97828734
96replication fork processing (GO:0031297)2.97568732
97aerobic respiration (GO:0009060)2.95387152
98histone mRNA metabolic process (GO:0008334)2.95106524
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93286462
100deoxyribonucleotide biosynthetic process (GO:0009263)2.93073419
101* transcription-coupled nucleotide-excision repair (GO:0006283)2.91629095
102positive regulation of mRNA metabolic process (GO:1903313)2.90531753
103mitotic recombination (GO:0006312)2.88615988
104cellular component biogenesis (GO:0044085)2.88293765
105rRNA modification (GO:0000154)2.87544178
106protein localization to mitochondrion (GO:0070585)2.87535923
107regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.87246159
108positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.87246159
109attachment of spindle microtubules to kinetochore (GO:0008608)2.86942558
110prenylation (GO:0097354)2.84907463
111protein prenylation (GO:0018342)2.84907463
112positive regulation of ligase activity (GO:0051351)2.82917315
113C-terminal protein lipidation (GO:0006501)2.82033350
114ribosomal large subunit biogenesis (GO:0042273)2.81654604
115positive regulation of protein homodimerization activity (GO:0090073)2.80353209
116rRNA catabolic process (GO:0016075)2.80321690
117platelet dense granule organization (GO:0060155)2.79895898
118GMP metabolic process (GO:0046037)2.79385485
119positive regulation of mRNA processing (GO:0050685)2.78785543
120telomere maintenance via telomere lengthening (GO:0010833)2.77843995
121double-strand break repair via homologous recombination (GO:0000724)2.77801159
122positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.76989761
123regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.76989761
124formation of translation preinitiation complex (GO:0001731)2.76756125
125DNA double-strand break processing (GO:0000729)2.76545623
126ribonucleoprotein complex disassembly (GO:0032988)2.76384911
127recombinational repair (GO:0000725)2.75867903
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75396431
129spliceosomal snRNP assembly (GO:0000387)2.73829757
130ribosome biogenesis (GO:0042254)2.71752832
131* G1/S transition of mitotic cell cycle (GO:0000082)2.71353408
132* cell cycle G1/S phase transition (GO:0044843)2.71353408
133NADH metabolic process (GO:0006734)2.70904126
134kinetochore assembly (GO:0051382)2.70497979
135neuron cell-cell adhesion (GO:0007158)2.70342294
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69898898
137water-soluble vitamin biosynthetic process (GO:0042364)2.67368844
138protein K11-linked deubiquitination (GO:0035871)2.66304815
139GPI anchor biosynthetic process (GO:0006506)2.65934889
140C-terminal protein amino acid modification (GO:0018410)2.65010114
141positive regulation of mRNA 3-end processing (GO:0031442)2.63385824
142nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.63318091
143regulation of centriole replication (GO:0046599)2.62525715
144DNA ligation (GO:0006266)2.61971115
145kinetochore organization (GO:0051383)2.61057332
146positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59862423
147ribosome assembly (GO:0042255)2.59533956
148regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.57322947
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.54966732
150protein K11-linked ubiquitination (GO:0070979)2.54204173
151negative regulation of DNA recombination (GO:0045910)2.53440154
152pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.51804314
153reciprocal DNA recombination (GO:0035825)2.50949784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.77657890
2E2F7_22180533_ChIP-Seq_HELA_Human4.55138305
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.82891007
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.76383085
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74756832
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39142296
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.36055851
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34761559
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09586845
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.07472323
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01555474
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87054088
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78832412
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65543691
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61672706
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58443872
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.56422248
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53225807
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52761396
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51821430
21VDR_23849224_ChIP-Seq_CD4+_Human2.45051203
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37722906
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37260672
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.33711230
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.31622610
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31330409
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24831405
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18569835
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.13709852
30ZNF274_21170338_ChIP-Seq_K562_Hela2.10290588
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.08736793
32DCP1A_22483619_ChIP-Seq_HELA_Human2.06998787
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05928892
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03691583
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02271636
36YY1_21170310_ChIP-Seq_MESCs_Mouse2.01268794
37* ELK1_19687146_ChIP-ChIP_HELA_Human1.97130281
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96550020
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92272182
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85431372
41FUS_26573619_Chip-Seq_HEK293_Human1.84735821
42GBX2_23144817_ChIP-Seq_PC3_Human1.84644172
43TAF15_26573619_Chip-Seq_HEK293_Human1.84104647
44GABP_19822575_ChIP-Seq_HepG2_Human1.82971307
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82619580
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79948531
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79326612
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78358011
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76386911
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68275532
51XRN2_22483619_ChIP-Seq_HELA_Human1.66442543
52GATA1_22025678_ChIP-Seq_K562_Human1.65070281
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64127595
54TTF2_22483619_ChIP-Seq_HELA_Human1.61803667
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60310276
56* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52383636
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52086809
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50671743
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47771253
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47450943
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.45740652
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44455717
63IRF1_19129219_ChIP-ChIP_H3396_Human1.40820083
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39768431
65* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37503801
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36618481
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.34359040
68EWS_26573619_Chip-Seq_HEK293_Human1.32672874
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31086791
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29959698
71* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28189946
72MYC_18940864_ChIP-ChIP_HL60_Human1.24485800
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22599420
74TP53_22573176_ChIP-Seq_HFKS_Human1.22116212
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21006364
76CBP_20019798_ChIP-Seq_JUKART_Human1.21006364
77SALL4_22934838_ChIP-ChIP_CD34+_Human1.15751368
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14089163
79GATA3_26560356_Chip-Seq_TH2_Human1.13419913
80EZH2_22144423_ChIP-Seq_EOC_Human1.13241270
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13122721
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12919007
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11024463
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.10732959
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.10406904
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09830775
87* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08539992
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.08534357
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06413342
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06226959
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.05825805
92VDR_22108803_ChIP-Seq_LS180_Human1.05258858
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04654637
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04618650
95SMAD4_21799915_ChIP-Seq_A2780_Human1.04582037
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04314022
97P53_22387025_ChIP-Seq_ESCs_Mouse1.03975878
98IGF1R_20145208_ChIP-Seq_DFB_Human1.03946977
99* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03073569
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02118250
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00277171
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99847988
103NANOG_19829295_ChIP-Seq_ESCs_Human0.99492497
104SOX2_19829295_ChIP-Seq_ESCs_Human0.99492497
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98541383
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98434615
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97281552
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97157995
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97124441
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.97077947
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96812694
112SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96416625
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96082558
114TCF4_23295773_ChIP-Seq_U87_Human0.96022022
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.95162438
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94746473
117FOXM1_23109430_ChIP-Seq_U2OS_Human0.94403836
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93427296
119* FLI1_21867929_ChIP-Seq_TH2_Mouse0.93037401
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92989714
121STAT3_18555785_Chip-Seq_ESCs_Mouse0.92849996
122OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92058194
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91649909
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91630106
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91617485
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91428797
127TCF4_22108803_ChIP-Seq_LS180_Human0.91349626
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.91158270
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.90456841
130* P300_19829295_ChIP-Seq_ESCs_Human0.90388005
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90220562
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89243556
133CIITA_25753668_ChIP-Seq_RAJI_Human0.88828477
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88034783
135* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83216194
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82330457
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81939124
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.81317279
139* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80452540
140AR_21909140_ChIP-Seq_LNCAP_Human0.80432646
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79898044
142KDM5A_27292631_Chip-Seq_BREAST_Human0.79323310
143JUN_21703547_ChIP-Seq_K562_Human0.78255879
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76968986
145ER_23166858_ChIP-Seq_MCF-7_Human0.76269067
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75297536
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74235275
148REST_19997604_ChIP-ChIP_NEURONS_Mouse0.74225597
149SOX9_26525672_Chip-Seq_HEART_Mouse0.74093333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.92005767
2MP0003880_abnormal_central_pattern3.72873892
3MP0008877_abnormal_DNA_methylation3.14697118
4MP0001529_abnormal_vocalization3.08671000
5MP0002102_abnormal_ear_morphology3.02987910
6MP0010094_abnormal_chromosome_stability2.66005024
7MP0006072_abnormal_retinal_apoptosis2.65116353
8MP0005646_abnormal_pituitary_gland2.55306663
9MP0008058_abnormal_DNA_repair2.49576827
10MP0001188_hyperpigmentation2.46352960
11MP0001986_abnormal_taste_sensitivity2.45234950
12MP0004957_abnormal_blastocyst_morpholog2.43289067
13MP0003693_abnormal_embryo_hatching2.39595640
14MP0001905_abnormal_dopamine_level2.23010034
15MP0009745_abnormal_behavioral_response2.15920763
16MP0004147_increased_porphyrin_level2.14600692
17MP0009046_muscle_twitch2.13083983
18MP0002822_catalepsy2.05389491
19MP0002736_abnormal_nociception_after2.02114650
20MP0003806_abnormal_nucleotide_metabolis1.97966318
21MP0002272_abnormal_nervous_system1.97665000
22MP0003635_abnormal_synaptic_transmissio1.94448082
23MP0002064_seizures1.94192476
24MP0001984_abnormal_olfaction1.90567533
25MP0008057_abnormal_DNA_replication1.90359140
26MP0003787_abnormal_imprinting1.83887624
27MP0006036_abnormal_mitochondrial_physio1.80263062
28MP0001968_abnormal_touch/_nociception1.76243160
29MP0002572_abnormal_emotion/affect_behav1.76116361
30MP0003136_yellow_coat_color1.76082787
31MP0004142_abnormal_muscle_tone1.74866897
32MP0004859_abnormal_synaptic_plasticity1.73460371
33MP0006276_abnormal_autonomic_nervous1.72482675
34MP0002876_abnormal_thyroid_physiology1.70084350
35MP0003123_paternal_imprinting1.69341016
36MP0008932_abnormal_embryonic_tissue1.69237970
37MP0003786_premature_aging1.66697482
38MP0002396_abnormal_hematopoietic_system1.65921364
39MP0002063_abnormal_learning/memory/cond1.65833412
40MP0002735_abnormal_chemical_nociception1.65808120
41MP0003111_abnormal_nucleus_morphology1.65436706
42MP0005253_abnormal_eye_physiology1.62445069
43MP0001919_abnormal_reproductive_system1.62040431
44MP0006292_abnormal_olfactory_placode1.60869547
45MP0003077_abnormal_cell_cycle1.60546147
46MP0009697_abnormal_copulation1.60102843
47MP0005171_absent_coat_pigmentation1.57648498
48MP0003121_genomic_imprinting1.56530718
49MP0008995_early_reproductive_senescence1.55973111
50MP0002638_abnormal_pupillary_reflex1.51220921
51MP0006035_abnormal_mitochondrial_morpho1.49454536
52MP0003122_maternal_imprinting1.49183583
53MP0008007_abnormal_cellular_replicative1.47527800
54MP0003195_calcinosis1.44937884
55MP0003724_increased_susceptibility_to1.44334351
56MP0005389_reproductive_system_phenotype1.40195543
57MP0001486_abnormal_startle_reflex1.39259856
58MP0003656_abnormal_erythrocyte_physiolo1.37261929
59MP0003718_maternal_effect1.31428093
60MP0000015_abnormal_ear_pigmentation1.29383678
61MP0002734_abnormal_mechanical_nocicepti1.29009287
62MP0000372_irregular_coat_pigmentation1.27605405
63MP0002067_abnormal_sensory_capabilities1.27269534
64MP0000427_abnormal_hair_cycle1.26836634
65MP0005075_abnormal_melanosome_morpholog1.24957602
66MP0002095_abnormal_skin_pigmentation1.24326666
67MP0005174_abnormal_tail_pigmentation1.23805145
68MP0003763_abnormal_thymus_physiology1.17873095
69MP0005386_behavior/neurological_phenoty1.17138028
70MP0004924_abnormal_behavior1.17138028
71MP0001501_abnormal_sleep_pattern1.15932061
72MP0002837_dystrophic_cardiac_calcinosis1.12276697
73MP0004215_abnormal_myocardial_fiber1.08981008
74MP0008260_abnormal_autophagy1.08538900
75MP0001764_abnormal_homeostasis1.05143657
76MP0002163_abnormal_gland_morphology1.04300482
77MP0009379_abnormal_foot_pigmentation1.03847504
78MP0001970_abnormal_pain_threshold1.02953524
79MP0002009_preneoplasia1.01233986
80MP0003879_abnormal_hair_cell1.00731462
81MP0002938_white_spotting1.00064271
82MP0001800_abnormal_humoral_immune0.99801346
83MP0001835_abnormal_antigen_presentation0.99184353
84MP0004270_analgesia0.97666552
85MP0001440_abnormal_grooming_behavior0.97639141
86MP0000689_abnormal_spleen_morphology0.96253637
87MP0002148_abnormal_hypersensitivity_rea0.95826963
88MP0002160_abnormal_reproductive_system0.95810295
89MP0005409_darkened_coat_color0.94171542
90MP0002751_abnormal_autonomic_nervous0.93773202
91MP0005397_hematopoietic_system_phenotyp0.92859246
92MP0001545_abnormal_hematopoietic_system0.92859246
93MP0005266_abnormal_metabolism0.92533442
94MP0002277_abnormal_respiratory_mucosa0.92327681
95MP0002184_abnormal_innervation0.92214165
96MP0000631_abnormal_neuroendocrine_gland0.91873226
97MP0002557_abnormal_social/conspecific_i0.90739268
98MP0002210_abnormal_sex_determination0.89894311
99MP0002234_abnormal_pharynx_morphology0.89673059
100MP0005379_endocrine/exocrine_gland_phen0.88284755
101MP0000681_abnormal_thyroid_gland0.88108947
102MP0005551_abnormal_eye_electrophysiolog0.87923419
103MP0005499_abnormal_olfactory_system0.87848791
104MP0005394_taste/olfaction_phenotype0.87848791
105MP0001485_abnormal_pinna_reflex0.86872214
106MP0001963_abnormal_hearing_physiology0.86840903
107MP0003011_delayed_dark_adaptation0.86201145
108MP0003950_abnormal_plasma_membrane0.85120890
109MP0001119_abnormal_female_reproductive0.83925898
110MP0002398_abnormal_bone_marrow0.83179422
111MP0005645_abnormal_hypothalamus_physiol0.82191979
112MP0002166_altered_tumor_susceptibility0.82032915
113MP0008872_abnormal_physiological_respon0.80507974
114MP0005423_abnormal_somatic_nervous0.80308510
115MP0008789_abnormal_olfactory_epithelium0.79685510
116MP0010386_abnormal_urinary_bladder0.79054440
117MP0002733_abnormal_thermal_nociception0.77902903
118MP0009765_abnormal_xenobiotic_induced0.77232688
119MP0003646_muscle_fatigue0.77113312
120MP0005671_abnormal_response_to0.77055470
121MP0004742_abnormal_vestibular_system0.76629090
122MP0002723_abnormal_immune_serum0.76256802
123MP0002006_tumorigenesis0.76055858
124MP0002066_abnormal_motor_capabilities/c0.75546048
125MP0008569_lethality_at_weaning0.75143626
126MP0001929_abnormal_gametogenesis0.74808654
127MP0001145_abnormal_male_reproductive0.73862596
128MP0004145_abnormal_muscle_electrophysio0.73024120
129MP0005000_abnormal_immune_tolerance0.72564829
130MP0003698_abnormal_male_reproductive0.72560759
131MP0002722_abnormal_immune_system0.71693265
132MP0002132_abnormal_respiratory_system0.70889644
133MP0005367_renal/urinary_system_phenotyp0.70470410
134MP0000516_abnormal_urinary_system0.70470410
135MP0000703_abnormal_thymus_morphology0.69866775
136MP0000653_abnormal_sex_gland0.69472968
137MP0002452_abnormal_antigen_presenting0.68607392
138MP0000358_abnormal_cell_content/0.68319978
139MP0002882_abnormal_neuron_morphology0.66353327
140MP0001819_abnormal_immune_cell0.66150229
141MP0004811_abnormal_neuron_physiology0.64966830
142MP0002420_abnormal_adaptive_immunity0.64596056
143MP0003186_abnormal_redox_activity0.63732668

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.32322073
2Abnormal mitochondria in muscle tissue (HP:0008316)5.00782771
3Mitochondrial inheritance (HP:0001427)4.77854604
4Increased CSF lactate (HP:0002490)4.43685188
5Hepatocellular necrosis (HP:0001404)4.37330316
6Progressive macrocephaly (HP:0004481)4.37170700
7Acute encephalopathy (HP:0006846)4.11560425
8Focal motor seizures (HP:0011153)3.88779778
9Birth length less than 3rd percentile (HP:0003561)3.82473834
10Increased serum pyruvate (HP:0003542)3.69963598
11Abnormality of glycolysis (HP:0004366)3.69963598
12Hepatic necrosis (HP:0002605)3.68109840
13Increased serum lactate (HP:0002151)3.26392691
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22050577
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22050577
163-Methylglutaconic aciduria (HP:0003535)3.21134973
17Increased hepatocellular lipid droplets (HP:0006565)3.21052189
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.07174436
19Abnormality of alanine metabolism (HP:0010916)3.07174436
20Hyperalaninemia (HP:0003348)3.07174436
21Lactic acidosis (HP:0003128)2.99295180
22Cerebral hypomyelination (HP:0006808)2.92587456
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91816602
24Atonic seizures (HP:0010819)2.91382703
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.90868201
26Microvesicular hepatic steatosis (HP:0001414)2.89360974
27Exercise intolerance (HP:0003546)2.89031683
28Abnormal hair whorl (HP:0010721)2.88334004
29Methylmalonic aciduria (HP:0012120)2.84707440
30Medial flaring of the eyebrow (HP:0010747)2.82411370
31Molar tooth sign on MRI (HP:0002419)2.81916993
32Abnormality of midbrain morphology (HP:0002418)2.81916993
33Hypothermia (HP:0002045)2.79551513
34Nephrogenic diabetes insipidus (HP:0009806)2.78269123
35Methylmalonic acidemia (HP:0002912)2.77773480
36Neuroendocrine neoplasm (HP:0100634)2.77469520
37Respiratory failure (HP:0002878)2.75051235
38Lipid accumulation in hepatocytes (HP:0006561)2.73183276
39Congenital primary aphakia (HP:0007707)2.72498589
40Chronic hepatic failure (HP:0100626)2.71545207
41Gait imbalance (HP:0002141)2.70623001
42Optic disc pallor (HP:0000543)2.70328610
43IgG deficiency (HP:0004315)2.66538477
44Epileptic encephalopathy (HP:0200134)2.65153310
45Type I transferrin isoform profile (HP:0003642)2.59869818
46Hyperventilation (HP:0002883)2.56926831
47Leukodystrophy (HP:0002415)2.56830476
48Aplastic anemia (HP:0001915)2.56408225
49Pancreatic fibrosis (HP:0100732)2.55095012
50Type 2 muscle fiber atrophy (HP:0003554)2.55034560
51Renal cortical cysts (HP:0000803)2.51327463
52Renal Fanconi syndrome (HP:0001994)2.50538090
53Cerebral edema (HP:0002181)2.49112457
54Pheochromocytoma (HP:0002666)2.47945415
55Abnormality of the renal cortex (HP:0011035)2.46295820
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.42045544
57Respiratory difficulties (HP:0002880)2.41178257
58Stomatitis (HP:0010280)2.39339368
59Poor suck (HP:0002033)2.36483953
60Increased intramyocellular lipid droplets (HP:0012240)2.35363787
61Short middle phalanx of the 5th finger (HP:0004220)2.30741061
62Chromsome breakage (HP:0040012)2.29593744
63Abnormality of chromosome stability (HP:0003220)2.28730962
64Nephronophthisis (HP:0000090)2.27732173
65Volvulus (HP:0002580)2.24543736
66Muscle fiber atrophy (HP:0100295)2.21284594
67Abnormality of the labia minora (HP:0012880)2.20843560
68Poor coordination (HP:0002370)2.19613804
69Abnormal number of erythroid precursors (HP:0012131)2.18434930
70Febrile seizures (HP:0002373)2.17847366
71Emotional lability (HP:0000712)2.15016133
72Unsteady gait (HP:0002317)2.13420023
73CNS demyelination (HP:0007305)2.12165608
74Thyroiditis (HP:0100646)2.09897422
75Abnormal protein glycosylation (HP:0012346)2.09643756
76Abnormal glycosylation (HP:0012345)2.09643756
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09643756
78Abnormal protein N-linked glycosylation (HP:0012347)2.09643756
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.07274565
80Abnormality of the renal medulla (HP:0100957)2.03917691
81Abnormality of the pons (HP:0007361)2.03177497
82Congenital, generalized hypertrichosis (HP:0004540)2.03001672
83CNS hypomyelination (HP:0003429)2.02929802
84Exertional dyspnea (HP:0002875)2.02634845
85Pancreatic cysts (HP:0001737)2.01849827
86Abnormality of cells of the erythroid lineage (HP:0012130)2.01405536
87Abnormality of methionine metabolism (HP:0010901)1.99885034
88Oral leukoplakia (HP:0002745)1.99248228
89True hermaphroditism (HP:0010459)1.98932063
90Severe visual impairment (HP:0001141)1.95138365
91Absence seizures (HP:0002121)1.93229805
92Genital tract atresia (HP:0001827)1.92392563
93Metaphyseal dysplasia (HP:0100255)1.92089159
94Vaginal atresia (HP:0000148)1.91723246
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.91561959
96Macrocytic anemia (HP:0001972)1.91177790
97Postnatal microcephaly (HP:0005484)1.91017160
98Neutropenia (HP:0001875)1.89876246
99Hypoplasia of the pons (HP:0012110)1.89381094
100Inability to walk (HP:0002540)1.89191400
101Gaze-evoked nystagmus (HP:0000640)1.87789758
102Attenuation of retinal blood vessels (HP:0007843)1.87757063
103Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.87293135
104Lethargy (HP:0001254)1.86881930
105Stomach cancer (HP:0012126)1.86331449
106IgM deficiency (HP:0002850)1.85971746
107Abnormality of homocysteine metabolism (HP:0010919)1.84648891
108Homocystinuria (HP:0002156)1.84648891
109Degeneration of anterior horn cells (HP:0002398)1.84571954
110Abnormality of the anterior horn cell (HP:0006802)1.84571954
111Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84398824
112Severe combined immunodeficiency (HP:0004430)1.84077893
113Abnormality of the vitamin B12 metabolism (HP:0004341)1.84014052
114Delusions (HP:0000746)1.83919350
115Short tibia (HP:0005736)1.83465770
116Premature graying of hair (HP:0002216)1.83385682
117Breast hypoplasia (HP:0003187)1.82370133
118Reduced antithrombin III activity (HP:0001976)1.82111038
119Abnormality of vitamin B metabolism (HP:0004340)1.81938011
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.81255651
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79566465
122Small intestinal stenosis (HP:0012848)1.79411922
123Duodenal stenosis (HP:0100867)1.79411922
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.77637640
125Absent/shortened dynein arms (HP:0200106)1.77637640
126Visual hallucinations (HP:0002367)1.76016477
127Increased muscle lipid content (HP:0009058)1.75882293
128X-linked dominant inheritance (HP:0001423)1.74502702
129Abnormality of the prostate (HP:0008775)1.72540753
130Intestinal atresia (HP:0011100)1.72323916
131Progressive inability to walk (HP:0002505)1.72142284
132Fair hair (HP:0002286)1.71994361
133Sloping forehead (HP:0000340)1.71058419
134Dialeptic seizures (HP:0011146)1.70444422
135Large for gestational age (HP:0001520)1.70274901
136Rough bone trabeculation (HP:0100670)1.69767709
137Neoplasm of the peripheral nervous system (HP:0100007)1.69055470
138Patchy hypopigmentation of hair (HP:0011365)1.68788262
139Gliosis (HP:0002171)1.67778545
140Pancytopenia (HP:0001876)1.65373404
141Abnormality of renal resorption (HP:0011038)1.64618765
142Microretrognathia (HP:0000308)1.63797446
143Limb dystonia (HP:0002451)1.63253466
144Protruding tongue (HP:0010808)1.62934801
145Agnosia (HP:0010524)1.54724302
146Broad foot (HP:0001769)1.54554315
147Supernumerary spleens (HP:0009799)1.53443026
148White forelock (HP:0002211)1.52974767
149Abnormality of the columella (HP:0009929)1.52228495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.22556436
2CASK3.69043452
3FRK3.27542707
4BUB13.15184627
5MAP3K123.03399617
6EIF2AK12.80477706
7MAP4K22.64113887
8TSSK62.61851566
9TAOK32.57796373
10WEE12.56138828
11EIF2AK32.37864254
12ACVR1B2.34871648
13CCNB12.33882107
14MAP2K72.32878337
15CDC72.08674958
16TNIK2.08290134
17MKNK22.05761486
18VRK12.01918460
19SRPK11.95057039
20MKNK11.94990082
21ERBB31.81479674
22PLK21.69080484
23DAPK11.60159101
24BRSK21.59736086
25CDK191.56332197
26NME11.53824893
27AKT31.51986449
28PRPF4B1.36127767
29TRIM281.32424047
30PLK31.31753377
31SIK31.23277932
32NTRK31.23046217
33BRAF1.22562115
34ARAF1.20197963
35PDK31.14721824
36PDK41.14721824
37BRSK11.12941072
38MAPK131.12783682
39ADRBK21.12492522
40MYLK1.12012355
41MAP3K41.08062454
42VRK21.06246085
43PLK41.03328784
44MUSK1.00133650
45BCR0.98992659
46GRK10.96565452
47MST40.96274925
48BMPR1B0.95964842
49PIM20.91126380
50NME20.89825029
51TXK0.88956603
52CLK10.85101547
53PLK10.82991591
54RPS6KA50.79515388
55NEK10.78337841
56BMPR20.78278764
57PRKCG0.77706794
58YES10.77118805
59OXSR10.76787513
60MINK10.76337187
61GRK50.74225278
62FES0.72195435
63NEK60.70682139
64ATR0.69627599
65AURKA0.68330738
66ZAK0.68114687
67EPHA40.67574906
68PDK20.64871244
69CSNK1G10.64497858
70TLK10.63360101
71PNCK0.63155059
72CAMK2B0.62138353
73PAK30.62117877
74CSNK1A1L0.60142024
75PASK0.59469505
76PINK10.58167587
77EIF2AK20.57787422
78IKBKB0.57692304
79CSNK1G30.57289987
80* CSNK2A10.56308726
81TNK20.55423873
82STK390.54529941
83RAF10.54327050
84BRD40.54087665
85CDK180.53760727
86ATM0.53067736
87KIT0.51654359
88MAPKAPK50.51440284
89BCKDK0.51168984
90ITK0.50354276
91TEC0.50241043
92PIK3CA0.49379446
93* CSNK2A20.48506873
94CAMKK20.48216267
95CAMK2A0.47690779
96ADRBK10.47516053
97PIM10.47427277
98CDK140.47406131
99STK38L0.47174463
100PKN10.46883897
101RPS6KB10.46303376
102CDK30.45709828
103PRKCE0.45556159
104LIMK10.45259635
105INSRR0.44325310
106CDK150.43531349
107AURKB0.42914846
108GRK70.42603808
109PIK3CG0.42224714
110TRPM70.40873160
111CDK11A0.40871182
112TTK0.40815623
113DYRK1A0.40628387
114ERBB40.39097988
115CHEK20.39020577
116DYRK30.38667859
117DYRK20.37164499
118STK40.36741628
119NLK0.35833604
120RPS6KA40.35645752
121CAMK2G0.35338478
122ILK0.35119871
123IKBKE0.34736493
124TAOK20.34521740
125MARK10.34337669
126IRAK10.33680322
127WNK30.33492042
128PBK0.33449800
129CSNK1G20.33065453
130MARK30.31721649
131NUAK10.31270344
132MAP2K40.31231149
133CAMK2D0.30893473
134CDK70.30739990
135SYK0.30295102
136IGF1R0.29702671
137EPHA30.29148451
138LCK0.29048838
139PRKG10.26453453

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.21867255
2Oxidative phosphorylation_Homo sapiens_hsa001903.67726972
3DNA replication_Homo sapiens_hsa030303.49114842
4RNA polymerase_Homo sapiens_hsa030203.44687263
5Mismatch repair_Homo sapiens_hsa034303.23260676
6Parkinsons disease_Homo sapiens_hsa050123.18440492
7Protein export_Homo sapiens_hsa030602.69489118
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61950410
9Ribosome_Homo sapiens_hsa030102.61232722
10Huntingtons disease_Homo sapiens_hsa050162.40495683
11Homologous recombination_Homo sapiens_hsa034402.40244709
12Spliceosome_Homo sapiens_hsa030402.31663018
13Pyrimidine metabolism_Homo sapiens_hsa002402.25941251
14Alzheimers disease_Homo sapiens_hsa050102.24561784
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18143691
16* Nucleotide excision repair_Homo sapiens_hsa034202.14359597
17Collecting duct acid secretion_Homo sapiens_hsa049661.99975127
18Nicotine addiction_Homo sapiens_hsa050331.96650513
19Propanoate metabolism_Homo sapiens_hsa006401.94086568
20Base excision repair_Homo sapiens_hsa034101.93756980
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90195346
22RNA transport_Homo sapiens_hsa030131.72423982
23* Basal transcription factors_Homo sapiens_hsa030221.69797193
24Non-homologous end-joining_Homo sapiens_hsa034501.68174200
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67089834
26Purine metabolism_Homo sapiens_hsa002301.63372308
27RNA degradation_Homo sapiens_hsa030181.62219977
28Synaptic vesicle cycle_Homo sapiens_hsa047211.62020106
29Vibrio cholerae infection_Homo sapiens_hsa051101.46373638
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46020815
31Fanconi anemia pathway_Homo sapiens_hsa034601.40689094
32* Cell cycle_Homo sapiens_hsa041101.31081338
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20791083
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20258090
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.16660207
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15031690
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12918204
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11692887
39Butanoate metabolism_Homo sapiens_hsa006501.06345690
40Nitrogen metabolism_Homo sapiens_hsa009101.05877629
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98961768
42Asthma_Homo sapiens_hsa053100.98845307
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97713284
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97170996
45Cardiac muscle contraction_Homo sapiens_hsa042600.93938349
46Vitamin B6 metabolism_Homo sapiens_hsa007500.92599574
47GABAergic synapse_Homo sapiens_hsa047270.91418108
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90042273
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.85569700
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85476605
51Amphetamine addiction_Homo sapiens_hsa050310.84659413
52Regulation of autophagy_Homo sapiens_hsa041400.84427356
53mRNA surveillance pathway_Homo sapiens_hsa030150.82955031
54Morphine addiction_Homo sapiens_hsa050320.82445819
55Circadian rhythm_Homo sapiens_hsa047100.80595440
56Allograft rejection_Homo sapiens_hsa053300.79260071
57Serotonergic synapse_Homo sapiens_hsa047260.77370629
58Oocyte meiosis_Homo sapiens_hsa041140.77343094
59Linoleic acid metabolism_Homo sapiens_hsa005910.74998464
60Circadian entrainment_Homo sapiens_hsa047130.74751888
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73890060
62Olfactory transduction_Homo sapiens_hsa047400.73334363
63Phototransduction_Homo sapiens_hsa047440.72854380
64Taste transduction_Homo sapiens_hsa047420.72782146
65Pyruvate metabolism_Homo sapiens_hsa006200.72245831
66Graft-versus-host disease_Homo sapiens_hsa053320.71690404
67Tryptophan metabolism_Homo sapiens_hsa003800.70915454
68Selenocompound metabolism_Homo sapiens_hsa004500.68226944
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67663699
70Long-term potentiation_Homo sapiens_hsa047200.66544711
71Dopaminergic synapse_Homo sapiens_hsa047280.66223063
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.66126573
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66073022
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66022184
75N-Glycan biosynthesis_Homo sapiens_hsa005100.65568860
76One carbon pool by folate_Homo sapiens_hsa006700.64776011
77Rheumatoid arthritis_Homo sapiens_hsa053230.64397497
78Epstein-Barr virus infection_Homo sapiens_hsa051690.63882933
79Peroxisome_Homo sapiens_hsa041460.62711805
80Type I diabetes mellitus_Homo sapiens_hsa049400.60699268
81Metabolic pathways_Homo sapiens_hsa011000.60430848
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59628805
83Glutamatergic synapse_Homo sapiens_hsa047240.58542891
84Caffeine metabolism_Homo sapiens_hsa002320.56759673
85Legionellosis_Homo sapiens_hsa051340.55596490
86Fatty acid elongation_Homo sapiens_hsa000620.54700753
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53009825
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.52084383
89Hematopoietic cell lineage_Homo sapiens_hsa046400.51284381
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50886655
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50816616
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50487975
93Steroid biosynthesis_Homo sapiens_hsa001000.50395308
94Calcium signaling pathway_Homo sapiens_hsa040200.49233762
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49199670
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48276808
97Phagosome_Homo sapiens_hsa041450.46000631
98Alcoholism_Homo sapiens_hsa050340.43952800
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43655976
100Carbon metabolism_Homo sapiens_hsa012000.42714865
101Folate biosynthesis_Homo sapiens_hsa007900.39935995
102Ether lipid metabolism_Homo sapiens_hsa005650.39022692
103T cell receptor signaling pathway_Homo sapiens_hsa046600.38397348
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37912159
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37456110
106Long-term depression_Homo sapiens_hsa047300.37400439
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36697879
108Fatty acid biosynthesis_Homo sapiens_hsa000610.35568010
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.34449718
110Pentose phosphate pathway_Homo sapiens_hsa000300.33591011
111Biosynthesis of amino acids_Homo sapiens_hsa012300.33447309
112Chemical carcinogenesis_Homo sapiens_hsa052040.33007901
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32658169
114Measles_Homo sapiens_hsa051620.31905290
115Sulfur metabolism_Homo sapiens_hsa009200.31829539
116p53 signaling pathway_Homo sapiens_hsa041150.29787211
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26156654
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25708936
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.24052773
120Primary immunodeficiency_Homo sapiens_hsa053400.24028563
121Insulin secretion_Homo sapiens_hsa049110.23448185
122Fructose and mannose metabolism_Homo sapiens_hsa000510.21580906
123Cholinergic synapse_Homo sapiens_hsa047250.21170018
124Antigen processing and presentation_Homo sapiens_hsa046120.20505740
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20159934
126Glutathione metabolism_Homo sapiens_hsa004800.18952253
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18397715
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17595272
129Cocaine addiction_Homo sapiens_hsa050300.15728236
130Salivary secretion_Homo sapiens_hsa049700.14549276
131Arachidonic acid metabolism_Homo sapiens_hsa005900.13102569
132Sphingolipid metabolism_Homo sapiens_hsa006000.13046045
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12904110
134Autoimmune thyroid disease_Homo sapiens_hsa053200.11673478
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09293996
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08746055
137Systemic lupus erythematosus_Homo sapiens_hsa053220.08635685

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