CCNHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.82379894
2mannosylation (GO:0097502)6.19733983
3tolerance induction (GO:0002507)5.87385873
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.51272278
5protein K11-linked deubiquitination (GO:0035871)4.90151968
6somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.81939589
7isotype switching (GO:0045190)4.81939589
8somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.81939589
9regulation of mitotic spindle checkpoint (GO:1903504)4.79393500
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.79393500
11preassembly of GPI anchor in ER membrane (GO:0016254)4.63888507
12cytidine metabolic process (GO:0046087)4.62226683
13cytidine catabolic process (GO:0006216)4.62226683
14cytidine deamination (GO:0009972)4.62226683
15negative regulation of telomere maintenance (GO:0032205)4.38295212
16regulation of chronic inflammatory response (GO:0002676)4.25453660
17GPI anchor metabolic process (GO:0006505)4.25323457
18pyrimidine dimer repair (GO:0006290)4.14178403
19signal peptide processing (GO:0006465)4.08523920
20GPI anchor biosynthetic process (GO:0006506)4.00545516
21pyrimidine ribonucleoside catabolic process (GO:0046133)3.90248719
22regulation of immunoglobulin secretion (GO:0051023)3.85241828
23cellular response to ATP (GO:0071318)3.84207339
24wound healing, spreading of epidermal cells (GO:0035313)3.82759223
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73681356
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.64921772
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.64921772
28negative regulation of acute inflammatory response (GO:0002674)3.62329179
29positive regulation of endothelial cell differentiation (GO:0045603)3.60411276
30regulation of isotype switching to IgG isotypes (GO:0048302)3.57883656
31regulation of DNA damage checkpoint (GO:2000001)3.56655383
32nucleotide transmembrane transport (GO:1901679)3.49619574
33nucleotide-excision repair, DNA damage removal (GO:0000718)3.44947847
34DNA excision (GO:0044349)3.44947847
35protein neddylation (GO:0045116)3.40112926
36kynurenine metabolic process (GO:0070189)3.36484980
37peptidyl-threonine dephosphorylation (GO:0035970)3.35570851
38endoderm formation (GO:0001706)3.34903799
39positive regulation of oligodendrocyte differentiation (GO:0048714)3.32697719
40histone H2A ubiquitination (GO:0033522)3.32481649
41positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.28648614
42cell wall macromolecule catabolic process (GO:0016998)3.28424622
43gamma-aminobutyric acid transport (GO:0015812)3.21041280
44positive regulation of T cell differentiation in thymus (GO:0033089)3.20751786
45C-terminal protein amino acid modification (GO:0018410)3.18823853
46negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.18523051
47adaptation of signaling pathway (GO:0023058)3.17702043
48regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.13667881
49cellular response to interleukin-15 (GO:0071350)3.11728168
50regulation of endothelial cell differentiation (GO:0045601)3.05748597
51response to gravity (GO:0009629)3.04795633
52sleep (GO:0030431)3.02162564
53C-terminal protein lipidation (GO:0006501)3.01651522
54negative T cell selection (GO:0043383)2.99893925
55somatic recombination of immunoglobulin gene segments (GO:0016447)2.97754750
56GTP biosynthetic process (GO:0006183)2.96235958
57somatic diversification of immunoglobulins (GO:0016445)2.94790032
58response to interleukin-15 (GO:0070672)2.93915069
59positive regulation of T cell cytokine production (GO:0002726)2.92563844
60B cell activation involved in immune response (GO:0002312)2.92014375
61T-helper cell differentiation (GO:0042093)2.87886334
62CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.87886334
63negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.87494910
64iron-sulfur cluster assembly (GO:0016226)2.87057511
65metallo-sulfur cluster assembly (GO:0031163)2.87057511
66dendritic cell chemotaxis (GO:0002407)2.86323248
67protein targeting to Golgi (GO:0000042)2.85069531
68negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.78078899
69chemokine-mediated signaling pathway (GO:0070098)2.76915938
70mitotic cell cycle arrest (GO:0071850)2.76331760
71cell wall macromolecule metabolic process (GO:0044036)2.73164669
72transcription elongation from RNA polymerase I promoter (GO:0006362)2.72892759
73termination of RNA polymerase I transcription (GO:0006363)2.71651506
74detection of light stimulus involved in sensory perception (GO:0050962)2.71114111
75detection of light stimulus involved in visual perception (GO:0050908)2.71114111
76indole-containing compound catabolic process (GO:0042436)2.66843048
77indolalkylamine catabolic process (GO:0046218)2.66843048
78tryptophan catabolic process (GO:0006569)2.66843048
79establishment of protein localization to Golgi (GO:0072600)2.66402555
80peptidyl-histidine modification (GO:0018202)2.61142519
81multicellular organism reproduction (GO:0032504)2.60796693
82alpha-beta T cell differentiation involved in immune response (GO:0002293)2.60071365
83alpha-beta T cell activation involved in immune response (GO:0002287)2.60071365
84T cell differentiation involved in immune response (GO:0002292)2.60071365
85regulation of immunoglobulin production (GO:0002637)2.55849818
86negative regulation of bone resorption (GO:0045779)2.55605618
87RNA destabilization (GO:0050779)2.53632706
88indolalkylamine metabolic process (GO:0006586)2.53304421
89piRNA metabolic process (GO:0034587)2.52390137
90regulation of germinal center formation (GO:0002634)2.52052546
91signal complex assembly (GO:0007172)2.51783491
92actin nucleation (GO:0045010)2.50983131
93tumor necrosis factor-mediated signaling pathway (GO:0033209)2.50931353
94negative regulation of systemic arterial blood pressure (GO:0003085)2.50344525
95negative regulation of interleukin-1 beta production (GO:0032691)2.49507117
96regulation of T cell receptor signaling pathway (GO:0050856)2.49428701
97regulation of defense response to virus by host (GO:0050691)2.48693268
98tryptophan metabolic process (GO:0006568)2.47249300
99dendritic cell migration (GO:0036336)2.46804608
100regulation of cell cycle checkpoint (GO:1901976)2.45972011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.49926795
2FLI1_27457419_Chip-Seq_LIVER_Mouse3.07569907
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.05795782
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93717200
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92079570
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.91275000
7ZNF274_21170338_ChIP-Seq_K562_Hela2.81690957
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64626776
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.43147958
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35856555
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32131776
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.18981326
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.16646677
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16602446
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09121771
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05695756
17RUNX_20019798_ChIP-Seq_JUKART_Human2.05503691
18IGF1R_20145208_ChIP-Seq_DFB_Human1.95977997
19VDR_23849224_ChIP-Seq_CD4+_Human1.95935013
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95807520
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.90326638
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88930120
23MYC_18940864_ChIP-ChIP_HL60_Human1.88671002
24MYB_26560356_Chip-Seq_TH2_Human1.84069146
25TP53_22573176_ChIP-Seq_HFKS_Human1.79828613
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78932726
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77457612
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73620093
29TAF15_26573619_Chip-Seq_HEK293_Human1.69848418
30GATA3_26560356_Chip-Seq_TH2_Human1.69197261
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69000460
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67739945
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65649706
34IRF1_19129219_ChIP-ChIP_H3396_Human1.63870582
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60653766
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.59275589
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51589667
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49950029
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.49709386
40ER_23166858_ChIP-Seq_MCF-7_Human1.49306175
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.48142278
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45830400
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.45145015
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.44787937
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44223782
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.42508038
47ELK1_19687146_ChIP-ChIP_HELA_Human1.40184881
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.32692407
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31683519
50RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.30497529
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29413884
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29059543
53GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.28864354
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28501712
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28499083
56FOXP3_21729870_ChIP-Seq_TREG_Human1.26579137
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.25849538
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25849538
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.23664017
60GATA3_27048872_Chip-Seq_THYMUS_Human1.23260540
61P300_19829295_ChIP-Seq_ESCs_Human1.22974012
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19636034
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19308330
64CBP_20019798_ChIP-Seq_JUKART_Human1.19308330
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.18707196
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18265668
67GATA3_26560356_Chip-Seq_TH1_Human1.17766287
68TAF2_19829295_ChIP-Seq_ESCs_Human1.17149375
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14299891
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14109897
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13639755
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12644848
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.12582173
74CDX2_22108803_ChIP-Seq_LS180_Human1.12442539
75ERA_21632823_ChIP-Seq_H3396_Human1.12264450
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.11979751
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.11618669
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09866086
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04972412
80KDM5A_27292631_Chip-Seq_BREAST_Human1.04428526
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03629273
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03422197
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.02472207
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01561470
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01467017
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00983941
87MYC_19829295_ChIP-Seq_ESCs_Human0.98133249
88NCOR_22424771_ChIP-Seq_293T_Human0.97920139
89FLI1_21867929_ChIP-Seq_TH2_Mouse0.96540371
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96299761
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95660538
92P300_27268052_Chip-Seq_Bcells_Human0.95306439
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94988650
94P53_21459846_ChIP-Seq_SAOS-2_Human0.93429735
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92079357
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90172910
97AR_20517297_ChIP-Seq_VCAP_Human0.89192623
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88651978
99SOX2_19829295_ChIP-Seq_ESCs_Human0.88223659
100NANOG_19829295_ChIP-Seq_ESCs_Human0.88223659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.05689731
2MP0004147_increased_porphyrin_level3.99590546
3MP0003724_increased_susceptibility_to3.82038098
4MP0002102_abnormal_ear_morphology3.28521427
5MP0006072_abnormal_retinal_apoptosis3.11918270
6MP0005671_abnormal_response_to3.07542626
7MP0008877_abnormal_DNA_methylation3.06292940
8MP0001986_abnormal_taste_sensitivity2.67695461
9MP0006276_abnormal_autonomic_nervous2.47810267
10MP0002009_preneoplasia2.22429120
11MP0003195_calcinosis2.14973640
12MP0001835_abnormal_antigen_presentation2.10937088
13MP0001800_abnormal_humoral_immune1.99575339
14MP0000465_gastrointestinal_hemorrhage1.97537332
15MP0005000_abnormal_immune_tolerance1.90270077
16MP0004043_abnormal_pH_regulation1.87329944
17MP0008872_abnormal_physiological_respon1.77934536
18MP0003436_decreased_susceptibility_to1.77049857
19MP0002837_dystrophic_cardiac_calcinosis1.77027808
20MP0001501_abnormal_sleep_pattern1.76906756
21MP0000685_abnormal_immune_system1.74302093
22MP0002138_abnormal_hepatobiliary_system1.71008974
23MP0008875_abnormal_xenobiotic_pharmacok1.69707406
24MP0001968_abnormal_touch/_nociception1.67354506
25MP0002736_abnormal_nociception_after1.60251434
26MP0003646_muscle_fatigue1.59896067
27MP0002723_abnormal_immune_serum1.59459690
28MP0001919_abnormal_reproductive_system1.58993193
29MP0009785_altered_susceptibility_to1.53834521
30MP0002148_abnormal_hypersensitivity_rea1.51814067
31MP0002166_altered_tumor_susceptibility1.48292076
32MP0003787_abnormal_imprinting1.46117426
33MP0008058_abnormal_DNA_repair1.45471448
34MP0002452_abnormal_antigen_presenting1.44444556
35MP0005253_abnormal_eye_physiology1.42490398
36MP0001348_abnormal_lacrimal_gland1.39230586
37MP0003763_abnormal_thymus_physiology1.38331770
38MP0009780_abnormal_chondrocyte_physiolo1.38303308
39MP0001819_abnormal_immune_cell1.36746804
40MP0004145_abnormal_muscle_electrophysio1.36230594
41MP0006036_abnormal_mitochondrial_physio1.35434323
42MP0005387_immune_system_phenotype1.33175037
43MP0001790_abnormal_immune_system1.33175037
44MP0002420_abnormal_adaptive_immunity1.29591410
45MP0009764_decreased_sensitivity_to1.29207820
46MP0002876_abnormal_thyroid_physiology1.28127227
47MP0002653_abnormal_ependyma_morphology1.27446392
48MP0004885_abnormal_endolymph1.24425170
49MP0009046_muscle_twitch1.24035639
50MP0005551_abnormal_eye_electrophysiolog1.21313714
51MP0006035_abnormal_mitochondrial_morpho1.17183370
52MP0002272_abnormal_nervous_system1.15180595
53MP0004130_abnormal_muscle_cell1.14422964
54MP0005670_abnormal_white_adipose1.14049392
55MP0001533_abnormal_skeleton_physiology1.12974178
56MP0001873_stomach_inflammation1.12382835
57MP0003656_abnormal_erythrocyte_physiolo1.10674129
58MP0005389_reproductive_system_phenotype1.08872868
59MP0000689_abnormal_spleen_morphology1.06374646
60MP0004742_abnormal_vestibular_system1.05955101
61MP0009333_abnormal_splenocyte_physiolog1.05925044
62MP0009765_abnormal_xenobiotic_induced1.05061820
63MP0005167_abnormal_blood-brain_barrier1.04572904
64MP0005025_abnormal_response_to1.00965082
65MP0002419_abnormal_innate_immunity1.00386426
66MP0000703_abnormal_thymus_morphology0.98708601
67MP0009745_abnormal_behavioral_response0.98541577
68MP0005257_abnormal_intraocular_pressure0.97802531
69MP0002006_tumorigenesis0.96431856
70MP0000427_abnormal_hair_cycle0.95964524
71MP0003718_maternal_effect0.91728187
72MP0002398_abnormal_bone_marrow0.91585614
73MP0000716_abnormal_immune_system0.90620928
74MP0002405_respiratory_system_inflammati0.90611139
75MP0005645_abnormal_hypothalamus_physiol0.89406001
76MP0002722_abnormal_immune_system0.88354375
77MP0005310_abnormal_salivary_gland0.87029478
78MP0002735_abnormal_chemical_nociception0.86860885
79MP0001845_abnormal_inflammatory_respons0.86262210
80MP0000372_irregular_coat_pigmentation0.85771249
81MP0001765_abnormal_ion_homeostasis0.84068191
82MP0000013_abnormal_adipose_tissue0.83142724
83MP0005646_abnormal_pituitary_gland0.82567088
84MP0004142_abnormal_muscle_tone0.81563497
85MP0003252_abnormal_bile_duct0.81543136
86MP0000015_abnormal_ear_pigmentation0.79634991
87MP0002396_abnormal_hematopoietic_system0.78840488
88MP0003786_premature_aging0.77977119
89MP0002234_abnormal_pharynx_morphology0.76682340
90MP0004782_abnormal_surfactant_physiolog0.75593777
91MP0002909_abnormal_adrenal_gland0.75486480
92MP0002095_abnormal_skin_pigmentation0.75025213
93MP0002098_abnormal_vibrissa_morphology0.74184400
94MP0003011_delayed_dark_adaptation0.72125580
95MP0003866_abnormal_defecation0.71192384
96MP0003795_abnormal_bone_structure0.70653572
97MP0002429_abnormal_blood_cell0.70213805
98MP0002136_abnormal_kidney_physiology0.68952822
99MP0002163_abnormal_gland_morphology0.68167806
100MP0005636_abnormal_mineral_homeostasis0.67666607

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.73107228
2IgG deficiency (HP:0004315)5.08849613
3Large eyes (HP:0001090)4.31814309
4Absent/shortened dynein arms (HP:0200106)3.91724076
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.91724076
6Anteriorly placed anus (HP:0001545)3.14246180
7Large for gestational age (HP:0001520)3.13746461
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13611313
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13611313
10Inability to walk (HP:0002540)3.05430579
11Prostate neoplasm (HP:0100787)3.04394566
12Facial diplegia (HP:0001349)3.00716437
13Progressive microcephaly (HP:0000253)2.89630879
14Type II lissencephaly (HP:0007260)2.69218574
15Attenuation of retinal blood vessels (HP:0007843)2.68952318
16Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66159719
17Stomach cancer (HP:0012126)2.65287675
18Elevated erythrocyte sedimentation rate (HP:0003565)2.59526798
19Poikiloderma (HP:0001029)2.58092501
20Progressive inability to walk (HP:0002505)2.56370088
21Abnormal respiratory motile cilium morphology (HP:0005938)2.52955516
22Abnormal respiratory epithelium morphology (HP:0012253)2.52955516
23Type I transferrin isoform profile (HP:0003642)2.52877903
24Bilateral microphthalmos (HP:0007633)2.46941145
25Abnormality of T cells (HP:0002843)2.46105972
26Myositis (HP:0100614)2.43042000
27Abolished electroretinogram (ERG) (HP:0000550)2.39800038
28Methylmalonic acidemia (HP:0002912)2.38625676
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38392391
30Constricted visual fields (HP:0001133)2.37393171
31Retrobulbar optic neuritis (HP:0100654)2.37252357
32Optic neuritis (HP:0100653)2.37252357
33Optic disc pallor (HP:0000543)2.36680978
34Mitochondrial inheritance (HP:0001427)2.34544597
35Keratitis (HP:0000491)2.33568578
36Abnormality of the renal cortex (HP:0011035)2.32901765
37Acute necrotizing encephalopathy (HP:0006965)2.32087154
38Acute encephalopathy (HP:0006846)2.30192777
39Tented upper lip vermilion (HP:0010804)2.29634592
40Gaze-evoked nystagmus (HP:0000640)2.27585458
41Severe visual impairment (HP:0001141)2.27377201
42Pendular nystagmus (HP:0012043)2.25863480
43Increased CSF lactate (HP:0002490)2.24545341
44Ketoacidosis (HP:0001993)2.22918635
45Absent speech (HP:0001344)2.22131478
46Renal cortical cysts (HP:0000803)2.20587389
47Abnormal mitochondria in muscle tissue (HP:0008316)2.17110962
48Abnormality of T cell physiology (HP:0011840)2.14104216
49Neutropenia (HP:0001875)2.11288284
50Abnormal hand bone ossification (HP:0010660)2.10952707
51Esophageal neoplasm (HP:0100751)2.09792463
52Neoplasm of head and neck (HP:0012288)2.09792463
53T lymphocytopenia (HP:0005403)2.09604563
54Orchitis (HP:0100796)2.08966490
55Progressive macrocephaly (HP:0004481)2.08509242
56Abnormal drinking behavior (HP:0030082)2.05755829
57Polydipsia (HP:0001959)2.05755829
58Chromsome breakage (HP:0040012)2.04843793
59Keratoconjunctivitis sicca (HP:0001097)2.04199442
60Bony spicule pigmentary retinopathy (HP:0007737)2.02011093
61Concave nail (HP:0001598)2.01356543
62Abnormality of the pons (HP:0007361)2.00747088
63Hyperglycinuria (HP:0003108)1.99426819
64Severe combined immunodeficiency (HP:0004430)1.98837071
65Abnormal ciliary motility (HP:0012262)1.98777599
66Keratoconjunctivitis (HP:0001096)1.98606823
67Disproportionate short-trunk short stature (HP:0003521)1.98152209
68Methylmalonic aciduria (HP:0012120)1.94976413
69Conjunctival hamartoma (HP:0100780)1.94431303
70Hypomagnesemia (HP:0002917)1.94126760
71Abnormality of cochlea (HP:0000375)1.93143138
72Abnormality of T cell number (HP:0011839)1.92722877
73Tetany (HP:0001281)1.90681233
74Aplastic anemia (HP:0001915)1.88756813
75Chronic hepatic failure (HP:0100626)1.87988919
76Genetic anticipation (HP:0003743)1.87437655
77Conical tooth (HP:0000698)1.85404800
78Hypoplasia of the pons (HP:0012110)1.83899239
79Polyuria (HP:0000103)1.82344823
80Abnormality of carpal bone ossification (HP:0006257)1.81590495
81Thyroiditis (HP:0100646)1.81318604
82Humeroradial synostosis (HP:0003041)1.80344236
83Synostosis involving the elbow (HP:0003938)1.80344236
84Bone cyst (HP:0012062)1.77935632
85Prominent metopic ridge (HP:0005487)1.77207263
86Abnormal protein glycosylation (HP:0012346)1.76353185
87Abnormal glycosylation (HP:0012345)1.76353185
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76353185
89Abnormal protein N-linked glycosylation (HP:0012347)1.76353185
90Increased serum lactate (HP:0002151)1.76012780
91Abnormality of the prostate (HP:0008775)1.75194067
92Absent thumb (HP:0009777)1.74860723
93Abnormality of midbrain morphology (HP:0002418)1.74521634
94Molar tooth sign on MRI (HP:0002419)1.74521634
95Hepatocellular necrosis (HP:0001404)1.74175661
96Increased IgM level (HP:0003496)1.74092827
97Hypoplasia of the thymus (HP:0000778)1.73587429
98Alveolar cell carcinoma (HP:0006519)1.73166392
99Hepatic necrosis (HP:0002605)1.72699496
100Abnormal rod and cone electroretinograms (HP:0008323)1.71359726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK86.57056941
2TAOK36.02810611
3FRK4.45950789
4MAP2K23.42575224
5MAP4K23.19826138
6PLK43.03223825
7KDR2.56025035
8PINK12.41295274
9ADRBK22.19177193
10PDK22.11952689
11TXK2.11939970
12GRK62.11514694
13MAP4K12.08209556
14ZAK1.83112856
15TESK21.77038152
16IKBKB1.71340341
17MAP3K141.69127645
18TLK11.57246938
19TNK21.38522090
20IKBKE1.27988843
21GRK11.25681924
22TBK11.24950644
23PLK21.24461217
24MAP3K121.23110220
25MST41.19897356
26GRK71.19443403
27WNK41.10517547
28MAP2K11.02776457
29STK38L0.95427368
30DYRK30.93559770
31KIT0.91907900
32NEK60.88896313
33EIF2AK30.87882676
34PRKD20.83443910
35ZAP700.81651048
36EIF2AK20.79291102
37ITK0.76369300
38FLT30.76358387
39MAPK130.74954783
40JAK30.72802170
41MATK0.71610998
42LCK0.70938001
43SYK0.67523521
44WNK30.66953472
45PIM10.66785682
46MAP2K70.66613314
47MAPK70.65709582
48BCKDK0.60936275
49MAP3K70.58083483
50PRKCI0.58081949
51INSRR0.54811070
52STK390.54180836
53PRKCE0.53988733
54TRPM70.52417383
55BMPR1B0.50697289
56TIE10.49742197
57PBK0.49414040
58CSF1R0.48412624
59RPS6KB20.47143177
60MYLK0.46809283
61MAPK120.45841463
62EIF2AK10.45815822
63ADRBK10.45498105
64RPS6KA60.44917032
65DAPK20.44217746
66IGF1R0.41458525
67PRKCG0.41295829
68CAMK40.41172373
69BTK0.40967295
70NME10.40320870
71CAMKK20.40067612
72ABL10.39883672
73SIK20.38849739
74NUAK10.38845998
75CHUK0.37105045
76LIMK10.36848403
77PRKACA0.35454537
78RPS6KA50.34210630
79CAMK10.33400230
80OXSR10.32877237
81ERBB30.32671289
82CSNK1G30.32146785
83BLK0.32111258
84TEC0.31820831
85PRKCA0.30173545
86RPS6KL10.29629023
87RPS6KC10.29629023
88IRAK30.29255678
89EGFR0.28651216
90ILK0.28429133
91PRKCQ0.28200851
92FGR0.26840063
93LYN0.26379777
94CAMK2A0.26179205
95CSNK2A10.23047378
96PRKCD0.22961302
97OBSCN0.22631935
98PRKCH0.22365427
99PRKCB0.22153357
100RPS6KA40.21988899

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.30133308
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.83775182
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.80799608
4Primary immunodeficiency_Homo sapiens_hsa053402.54268858
5Oxidative phosphorylation_Homo sapiens_hsa001902.49459473
6Non-homologous end-joining_Homo sapiens_hsa034502.22992710
7Asthma_Homo sapiens_hsa053102.21038348
8Proteasome_Homo sapiens_hsa030502.17495162
9Basal transcription factors_Homo sapiens_hsa030222.09112698
10Graft-versus-host disease_Homo sapiens_hsa053322.05705078
11Allograft rejection_Homo sapiens_hsa053302.01304650
12RNA polymerase_Homo sapiens_hsa030201.99477422
13Protein export_Homo sapiens_hsa030601.99067113
14Parkinsons disease_Homo sapiens_hsa050121.90762488
15Autoimmune thyroid disease_Homo sapiens_hsa053201.88632988
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.82663707
17Tryptophan metabolism_Homo sapiens_hsa003801.75874187
18Phototransduction_Homo sapiens_hsa047441.72371196
19Caffeine metabolism_Homo sapiens_hsa002321.71417194
20Nucleotide excision repair_Homo sapiens_hsa034201.61004406
21Antigen processing and presentation_Homo sapiens_hsa046121.51186068
22Nitrogen metabolism_Homo sapiens_hsa009101.49869537
23T cell receptor signaling pathway_Homo sapiens_hsa046601.48108198
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47397580
25Linoleic acid metabolism_Homo sapiens_hsa005911.45406721
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43730528
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40594091
28RNA degradation_Homo sapiens_hsa030181.36766484
29Sulfur metabolism_Homo sapiens_hsa009201.35621106
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35435610
31Collecting duct acid secretion_Homo sapiens_hsa049661.32414771
32Fatty acid biosynthesis_Homo sapiens_hsa000611.31143620
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28882713
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26613072
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21553949
36Homologous recombination_Homo sapiens_hsa034401.20866562
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19617182
38Alzheimers disease_Homo sapiens_hsa050101.17059096
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14307164
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12142398
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10154720
42Type I diabetes mellitus_Homo sapiens_hsa049401.09480657
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08303943
44Rheumatoid arthritis_Homo sapiens_hsa053231.08093308
45ABC transporters_Homo sapiens_hsa020101.05519443
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03857102
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00651425
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96608026
49Butanoate metabolism_Homo sapiens_hsa006500.96454207
50Nicotine addiction_Homo sapiens_hsa050330.96155823
51Hematopoietic cell lineage_Homo sapiens_hsa046400.94496001
52Huntingtons disease_Homo sapiens_hsa050160.93820039
53Olfactory transduction_Homo sapiens_hsa047400.93493165
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.89225061
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88437632
56TNF signaling pathway_Homo sapiens_hsa046680.86751204
57Cardiac muscle contraction_Homo sapiens_hsa042600.83783260
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82226874
59Peroxisome_Homo sapiens_hsa041460.79115882
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78188269
61Ether lipid metabolism_Homo sapiens_hsa005650.76948499
62Phenylalanine metabolism_Homo sapiens_hsa003600.76843452
63One carbon pool by folate_Homo sapiens_hsa006700.73677685
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73574093
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.72691815
66Mineral absorption_Homo sapiens_hsa049780.71159593
67N-Glycan biosynthesis_Homo sapiens_hsa005100.70751082
68Pyrimidine metabolism_Homo sapiens_hsa002400.69857515
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67162324
70Retinol metabolism_Homo sapiens_hsa008300.66943705
71Morphine addiction_Homo sapiens_hsa050320.63399526
72Fanconi anemia pathway_Homo sapiens_hsa034600.63300012
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.60866133
74Circadian rhythm_Homo sapiens_hsa047100.60700534
75Fatty acid metabolism_Homo sapiens_hsa012120.58311672
76Taste transduction_Homo sapiens_hsa047420.57330401
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56411285
78Arachidonic acid metabolism_Homo sapiens_hsa005900.54138603
79Metabolic pathways_Homo sapiens_hsa011000.51625509
80Chemical carcinogenesis_Homo sapiens_hsa052040.47169949
81Fatty acid degradation_Homo sapiens_hsa000710.46317378
82Measles_Homo sapiens_hsa051620.43088704
83GABAergic synapse_Homo sapiens_hsa047270.40560184
84Leishmaniasis_Homo sapiens_hsa051400.39918812
85Ovarian steroidogenesis_Homo sapiens_hsa049130.39547211
86Tyrosine metabolism_Homo sapiens_hsa003500.39538858
87Fat digestion and absorption_Homo sapiens_hsa049750.39255656
88Shigellosis_Homo sapiens_hsa051310.37051509
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35984093
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.33960830
91Circadian entrainment_Homo sapiens_hsa047130.33960009
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32222731
93Serotonergic synapse_Homo sapiens_hsa047260.31677345
94Purine metabolism_Homo sapiens_hsa002300.31251212
95Sulfur relay system_Homo sapiens_hsa041220.28867783
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28770149
97Osteoclast differentiation_Homo sapiens_hsa043800.27849750
98RNA transport_Homo sapiens_hsa030130.25874375
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24541793
100Amphetamine addiction_Homo sapiens_hsa050310.23670346

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