

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | kinetochore organization (GO:0051383) | 4.63543616 |
| 2 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.12485344 |
| 3 | regulation of development, heterochronic (GO:0040034) | 4.11985549 |
| 4 | kinetochore assembly (GO:0051382) | 4.11304836 |
| 5 | nuclear pore organization (GO:0006999) | 4.01569697 |
| 6 | protein-DNA complex disassembly (GO:0032986) | 3.93722898 |
| 7 | nucleosome disassembly (GO:0006337) | 3.93722898 |
| 8 | DNA unwinding involved in DNA replication (GO:0006268) | 3.87897542 |
| 9 | nuclear pore complex assembly (GO:0051292) | 3.85615020 |
| 10 | establishment of integrated proviral latency (GO:0075713) | 3.83520059 |
| 11 | mitotic metaphase plate congression (GO:0007080) | 3.82581418 |
| 12 | mitotic chromosome condensation (GO:0007076) | 3.79452678 |
| 13 | DNA ligation (GO:0006266) | 3.74339199 |
| 14 | histone H2A acetylation (GO:0043968) | 3.74147295 |
| 15 | paraxial mesoderm development (GO:0048339) | 3.70082006 |
| 16 | sister chromatid segregation (GO:0000819) | 3.69958317 |
| 17 | regulation of timing of cell differentiation (GO:0048505) | 3.60279381 |
| 18 | meiotic chromosome segregation (GO:0045132) | 3.55605061 |
| 19 | mitotic sister chromatid segregation (GO:0000070) | 3.54167341 |
| 20 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.51398190 |
| 21 | protein localization to kinetochore (GO:0034501) | 3.44160874 |
| 22 | CENP-A containing nucleosome assembly (GO:0034080) | 3.41617255 |
| 23 | IMP biosynthetic process (GO:0006188) | 3.35191513 |
| 24 | regulation of sister chromatid cohesion (GO:0007063) | 3.33954221 |
| 25 | regulation of DNA methylation (GO:0044030) | 3.31441767 |
| 26 | chromatin remodeling at centromere (GO:0031055) | 3.30366015 |
| 27 | protein localization to chromosome, centromeric region (GO:0071459) | 3.26248949 |
| 28 | regulation of helicase activity (GO:0051095) | 3.25969102 |
| 29 | establishment of chromosome localization (GO:0051303) | 3.25397493 |
| 30 | olfactory bulb development (GO:0021772) | 3.25338463 |
| 31 | metaphase plate congression (GO:0051310) | 3.25215512 |
| 32 | mitotic sister chromatid cohesion (GO:0007064) | 3.24385615 |
| 33 | non-recombinational repair (GO:0000726) | 3.24170620 |
| 34 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.24170620 |
| 35 | mitotic nuclear envelope disassembly (GO:0007077) | 3.18544288 |
| 36 | ATP-dependent chromatin remodeling (GO:0043044) | 3.17484531 |
| 37 | pore complex assembly (GO:0046931) | 3.16811053 |
| 38 | protein localization to chromosome (GO:0034502) | 3.13789707 |
| 39 | proximal/distal pattern formation (GO:0009954) | 3.10790731 |
| 40 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.10274514 |
| 41 | DNA replication-independent nucleosome organization (GO:0034724) | 3.10274514 |
| 42 | DNA replication checkpoint (GO:0000076) | 3.08365638 |
| 43 | regulation of centriole replication (GO:0046599) | 3.07509145 |
| 44 | positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145) | 3.06657442 |
| 45 | dosage compensation (GO:0007549) | 3.06517287 |
| 46 | chromosome segregation (GO:0007059) | 3.05962314 |
| 47 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.04907037 |
| 48 | termination of RNA polymerase II transcription (GO:0006369) | 3.04852415 |
| 49 | DNA topological change (GO:0006265) | 3.03899334 |
| 50 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.03695920 |
| 51 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.03393049 |
| 52 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.03393049 |
| 53 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.03393049 |
| 54 | chromatin assembly or disassembly (GO:0006333) | 3.03357358 |
| 55 | cornea development in camera-type eye (GO:0061303) | 3.02690533 |
| 56 | DNA replication initiation (GO:0006270) | 3.02311665 |
| 57 | negative regulation of DNA recombination (GO:0045910) | 3.01983742 |
| 58 | neural tube formation (GO:0001841) | 3.01961232 |
| 59 | spindle checkpoint (GO:0031577) | 3.01820602 |
| 60 | negative regulation of mRNA processing (GO:0050686) | 3.01635184 |
| 61 | regulation of histone H3-K9 methylation (GO:0051570) | 2.99689229 |
| 62 | establishment of viral latency (GO:0019043) | 2.99570203 |
| 63 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 2.99373806 |
| 64 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.98653097 |
| 65 | negative regulation of RNA splicing (GO:0033119) | 2.98591838 |
| 66 | dorsal/ventral axis specification (GO:0009950) | 2.98155662 |
| 67 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.93400864 |
| 68 | regulation of spindle organization (GO:0090224) | 2.90981976 |
| 69 | pre-miRNA processing (GO:0031054) | 2.90132268 |
| 70 | replication fork processing (GO:0031297) | 2.89341180 |
| 71 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.89210576 |
| 72 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.89210576 |
| 73 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.89210576 |
| 74 | negative regulation of sister chromatid segregation (GO:0033046) | 2.89210576 |
| 75 | DNA double-strand break processing (GO:0000729) | 2.88649301 |
| 76 | histone H3-K9 methylation (GO:0051567) | 2.88232708 |
| 77 | chromatin assembly (GO:0031497) | 2.88126877 |
| 78 | histone exchange (GO:0043486) | 2.87848220 |
| 79 | regulation of chromosome segregation (GO:0051983) | 2.87122495 |
| 80 | membrane disassembly (GO:0030397) | 2.85360601 |
| 81 | nuclear envelope disassembly (GO:0051081) | 2.85360601 |
| 82 | negative regulation of chromosome segregation (GO:0051985) | 2.85287869 |
| 83 | centriole replication (GO:0007099) | 2.85238123 |
| 84 | DNA damage response, detection of DNA damage (GO:0042769) | 2.84102126 |
| 85 | mitotic spindle checkpoint (GO:0071174) | 2.83937454 |
| 86 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.82739522 |
| 87 | spliceosomal snRNP assembly (GO:0000387) | 2.82559447 |
| 88 | RNA splicing, via transesterification reactions (GO:0000375) | 2.82240233 |
| 89 | mitotic spindle assembly checkpoint (GO:0007094) | 2.81428100 |
| 90 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 2.81289111 |
| 91 | spindle assembly checkpoint (GO:0071173) | 2.80465708 |
| 92 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.80235330 |
| 93 | regulation of centrosome cycle (GO:0046605) | 2.79274363 |
| 94 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.78913998 |
| 95 | mRNA splicing, via spliceosome (GO:0000398) | 2.78913998 |
| 96 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.78489434 |
| 97 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.77763641 |
| 98 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.77763641 |
| 99 | nucleobase biosynthetic process (GO:0046112) | 2.77532878 |
| 100 | spliceosomal complex assembly (GO:0000245) | 2.77263045 |
| 101 | heterochromatin organization (GO:0070828) | 2.77216563 |
| 102 | neuron fate commitment (GO:0048663) | 2.77117422 |
| 103 | mitotic G2/M transition checkpoint (GO:0044818) | 2.76976241 |
| 104 | mRNA splice site selection (GO:0006376) | 2.76444074 |
| 105 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.76154856 |
| 106 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.76154856 |
| 107 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.76154856 |
| 108 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.75951174 |
| 109 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.73831149 |
| 110 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.73831149 |
| 111 | regulation of sister chromatid segregation (GO:0033045) | 2.73831149 |
| 112 | DNA strand elongation (GO:0022616) | 2.73497960 |
| 113 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.72972899 |
| 114 | purine nucleobase biosynthetic process (GO:0009113) | 2.72843257 |
| 115 | viral mRNA export from host cell nucleus (GO:0046784) | 2.71401632 |
| 116 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.69958972 |
| 117 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.69604560 |
| 118 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.69115517 |
| 119 | negative regulation of DNA-templated transcription, elongation (GO:0032785) | 2.69115517 |
| 120 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.68368073 |
| 121 | mitotic recombination (GO:0006312) | 2.67923285 |
| 122 | RNA export from nucleus (GO:0006405) | 2.65427117 |
| 123 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.65300633 |
| 124 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.65300633 |
| 125 | maturation of 5.8S rRNA (GO:0000460) | 2.64312523 |
| 126 | microtubule depolymerization (GO:0007019) | 2.63202677 |
| 127 | positive regulation of chromosome segregation (GO:0051984) | 2.62749888 |
| 128 | sister chromatid cohesion (GO:0007062) | 2.62635647 |
| 129 | mRNA export from nucleus (GO:0006406) | 2.61746129 |
| 130 | mRNA transport (GO:0051028) | 2.61719079 |
| 131 | negative regulation of DNA repair (GO:0045738) | 2.61538435 |
| 132 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.61243809 |
| 133 | regulation of DNA damage checkpoint (GO:2000001) | 2.59407613 |
| 134 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 2.58960735 |
| 135 | cell proliferation involved in metanephros development (GO:0072203) | 2.58913432 |
| 136 | embryonic foregut morphogenesis (GO:0048617) | 2.58733651 |
| 137 | DNA duplex unwinding (GO:0032508) | 2.57082024 |
| 138 | regulation of transcription from RNA polymerase I promoter (GO:0006356) | 2.56055384 |
| 139 | positive regulation of male gonad development (GO:2000020) | 2.55251333 |
| 140 | negative regulation of histone acetylation (GO:0035067) | 2.53840183 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.42975837 |
| 2 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 4.55194738 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.47129145 |
| 4 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 4.05223613 |
| 5 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 3.53009158 |
| 6 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.01830735 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.88893888 |
| 8 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.81958072 |
| 9 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.67810493 |
| 10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.51875651 |
| 11 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.46727584 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.46584079 |
| 13 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.39329113 |
| 14 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.37213581 |
| 15 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.36594852 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.35570168 |
| 17 | CIITA_25753668_ChIP-Seq_RAJI_Human | 2.28615065 |
| 18 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 2.25953882 |
| 19 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.24646045 |
| 20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.18076495 |
| 21 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.14974552 |
| 22 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.13229583 |
| 23 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.11061103 |
| 24 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 2.08819628 |
| 25 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.07383015 |
| 26 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.05056844 |
| 27 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.03330403 |
| 28 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.01494662 |
| 29 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 2.00291851 |
| 30 | E2F7_22180533_ChIP-Seq_HELA_Human | 11.0547063 |
| 31 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.94963107 |
| 32 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.94713221 |
| 33 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.93169907 |
| 34 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.91674000 |
| 35 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.90836318 |
| 36 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.89013313 |
| 37 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.85109579 |
| 38 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.84567097 |
| 39 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.84185544 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.81531268 |
| 41 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.76337622 |
| 42 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.73894642 |
| 43 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.70210157 |
| 44 | MYC_22102868_ChIP-Seq_BL_Human | 1.64663107 |
| 45 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.63288188 |
| 46 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.62820311 |
| 47 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.62586943 |
| 48 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.61705201 |
| 49 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.61231806 |
| 50 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.60496054 |
| 51 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.59998323 |
| 52 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.59242526 |
| 53 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.58582138 |
| 54 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.56943530 |
| 55 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.55784727 |
| 56 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.54263510 |
| 57 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.51902409 |
| 58 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.50489483 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.49304835 |
| 60 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.46936832 |
| 61 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.46285670 |
| 62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.45201750 |
| 63 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.45021058 |
| 64 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.43888180 |
| 65 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.43212861 |
| 66 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.42705556 |
| 67 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.42462018 |
| 68 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.38391058 |
| 69 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.38391058 |
| 70 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.38391058 |
| 71 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.35916370 |
| 72 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.34601508 |
| 73 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.33253925 |
| 74 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.32266257 |
| 75 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.31337556 |
| 76 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.31231275 |
| 77 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.29288129 |
| 78 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.28223635 |
| 79 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.24879010 |
| 80 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.23016534 |
| 81 | EWS_26573619_Chip-Seq_HEK293_Human | 1.22299446 |
| 82 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.21826430 |
| 83 | P300_19829295_ChIP-Seq_ESCs_Human | 1.20757288 |
| 84 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.20269320 |
| 85 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.20002949 |
| 86 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.18729394 |
| 87 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.16474977 |
| 88 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.14961296 |
| 89 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.13138164 |
| 90 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.11754951 |
| 91 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.11000151 |
| 92 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.05650549 |
| 93 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.01385375 |
| 94 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.01022192 |
| 95 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.99934031 |
| 96 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.98033631 |
| 97 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.97760433 |
| 98 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.97179194 |
| 99 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.96354187 |
| 100 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.95653091 |
| 101 | * GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.95505101 |
| 102 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95154303 |
| 103 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95111750 |
| 104 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.95111750 |
| 105 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 0.94235083 |
| 106 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.92684577 |
| 107 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.92537447 |
| 108 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.92259008 |
| 109 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.90504765 |
| 110 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.89825605 |
| 111 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.89294585 |
| 112 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.89294585 |
| 113 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.88252373 |
| 114 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.87193566 |
| 115 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.85936869 |
| 116 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85329410 |
| 117 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.84830452 |
| 118 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84367098 |
| 119 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.83690219 |
| 120 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.79796491 |
| 121 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.77745226 |
| 122 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.75443030 |
| 123 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.74896344 |
| 124 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.74070807 |
| 125 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.73603738 |
| 126 | FUS_26573619_Chip-Seq_HEK293_Human | 0.73168333 |
| 127 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.72063584 |
| 128 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.71993159 |
| 129 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.71971376 |
| 130 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.71177063 |
| 131 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.69897241 |
| 132 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.69582696 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003123_paternal_imprinting | 3.34743100 |
| 2 | MP0003121_genomic_imprinting | 3.19640100 |
| 3 | MP0010030_abnormal_orbit_morphology | 3.12039673 |
| 4 | MP0010094_abnormal_chromosome_stability | 2.85891298 |
| 5 | MP0000566_synostosis | 2.80130660 |
| 6 | MP0009053_abnormal_anal_canal | 2.74752751 |
| 7 | MP0003122_maternal_imprinting | 2.64860898 |
| 8 | MP0003077_abnormal_cell_cycle | 2.62110492 |
| 9 | MP0003111_abnormal_nucleus_morphology | 2.51301491 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.38933184 |
| 11 | MP0000537_abnormal_urethra_morphology | 2.37528525 |
| 12 | MP0002249_abnormal_larynx_morphology | 2.35004097 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.33852882 |
| 14 | MP0000049_abnormal_middle_ear | 2.27862677 |
| 15 | MP0008058_abnormal_DNA_repair | 2.26483659 |
| 16 | MP0003693_abnormal_embryo_hatching | 2.23770940 |
| 17 | MP0003315_abnormal_perineum_morphology | 2.10742141 |
| 18 | MP0008789_abnormal_olfactory_epithelium | 2.07012117 |
| 19 | MP0004957_abnormal_blastocyst_morpholog | 2.04233270 |
| 20 | MP0002234_abnormal_pharynx_morphology | 1.96801339 |
| 21 | MP0003937_abnormal_limbs/digits/tail_de | 1.94373322 |
| 22 | MP0003115_abnormal_respiratory_system | 1.92153469 |
| 23 | MP0005257_abnormal_intraocular_pressure | 1.72570398 |
| 24 | MP0005499_abnormal_olfactory_system | 1.71090050 |
| 25 | MP0005394_taste/olfaction_phenotype | 1.71090050 |
| 26 | MP0003941_abnormal_skin_development | 1.70804239 |
| 27 | MP0008932_abnormal_embryonic_tissue | 1.68332541 |
| 28 | MP0003385_abnormal_body_wall | 1.66372411 |
| 29 | MP0003942_abnormal_urinary_system | 1.65759373 |
| 30 | MP0003938_abnormal_ear_development | 1.59210787 |
| 31 | MP0000350_abnormal_cell_proliferation | 1.57208418 |
| 32 | MP0003221_abnormal_cardiomyocyte_apopto | 1.53196461 |
| 33 | MP0004197_abnormal_fetal_growth/weight/ | 1.52582213 |
| 34 | MP0001293_anophthalmia | 1.52479637 |
| 35 | MP0001730_embryonic_growth_arrest | 1.52371009 |
| 36 | MP0008057_abnormal_DNA_replication | 1.50717785 |
| 37 | MP0003787_abnormal_imprinting | 1.50496099 |
| 38 | MP0008877_abnormal_DNA_methylation | 1.49994491 |
| 39 | MP0000516_abnormal_urinary_system | 1.49231947 |
| 40 | MP0005367_renal/urinary_system_phenotyp | 1.49231947 |
| 41 | MP0001672_abnormal_embryogenesis/_devel | 1.48963186 |
| 42 | MP0005380_embryogenesis_phenotype | 1.48963186 |
| 43 | MP0003943_abnormal_hepatobiliary_system | 1.48841588 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.47548411 |
| 45 | MP0006072_abnormal_retinal_apoptosis | 1.46563422 |
| 46 | MP0003755_abnormal_palate_morphology | 1.44405611 |
| 47 | MP0002638_abnormal_pupillary_reflex | 1.44223904 |
| 48 | MP0002085_abnormal_embryonic_tissue | 1.43890265 |
| 49 | MP0003935_abnormal_craniofacial_develop | 1.42721128 |
| 50 | MP0001697_abnormal_embryo_size | 1.40857987 |
| 51 | MP0003984_embryonic_growth_retardation | 1.40484672 |
| 52 | MP0002088_abnormal_embryonic_growth/wei | 1.40462577 |
| 53 | MP0002653_abnormal_ependyma_morphology | 1.40080903 |
| 54 | MP0002938_white_spotting | 1.39248230 |
| 55 | MP0001286_abnormal_eye_development | 1.37597129 |
| 56 | MP0005248_abnormal_Harderian_gland | 1.37383526 |
| 57 | MP0004782_abnormal_surfactant_physiolog | 1.36929237 |
| 58 | MP0003119_abnormal_digestive_system | 1.35838876 |
| 59 | MP0003890_abnormal_embryonic-extraembry | 1.31663010 |
| 60 | MP0010307_abnormal_tumor_latency | 1.29298771 |
| 61 | MP0002084_abnormal_developmental_patter | 1.28280727 |
| 62 | MP0002177_abnormal_outer_ear | 1.26745814 |
| 63 | MP0004808_abnormal_hematopoietic_stem | 1.25619434 |
| 64 | MP0009697_abnormal_copulation | 1.24273337 |
| 65 | MP0004133_heterotaxia | 1.23859660 |
| 66 | MP0005391_vision/eye_phenotype | 1.23725149 |
| 67 | MP0001879_abnormal_lymphatic_vessel | 1.21558888 |
| 68 | MP0009672_abnormal_birth_weight | 1.21295803 |
| 69 | MP0005187_abnormal_penis_morphology | 1.20259299 |
| 70 | MP0002277_abnormal_respiratory_mucosa | 1.17766856 |
| 71 | MP0003136_yellow_coat_color | 1.17584129 |
| 72 | MP0002697_abnormal_eye_size | 1.17403008 |
| 73 | MP0002751_abnormal_autonomic_nervous | 1.16489843 |
| 74 | MP0002932_abnormal_joint_morphology | 1.16292275 |
| 75 | MP0001529_abnormal_vocalization | 1.15614989 |
| 76 | MP0002116_abnormal_craniofacial_bone | 1.13613468 |
| 77 | MP0003861_abnormal_nervous_system | 1.11183536 |
| 78 | MP0002233_abnormal_nose_morphology | 1.10888676 |
| 79 | MP0005076_abnormal_cell_differentiation | 1.06966860 |
| 80 | MP0002009_preneoplasia | 1.06824943 |
| 81 | MP0002111_abnormal_tail_morphology | 1.06424273 |
| 82 | MP0005253_abnormal_eye_physiology | 1.05116274 |
| 83 | MP0001119_abnormal_female_reproductive | 1.04878154 |
| 84 | MP0000432_abnormal_head_morphology | 1.03960653 |
| 85 | MP0002160_abnormal_reproductive_system | 1.02802242 |
| 86 | MP0002080_prenatal_lethality | 1.02618443 |
| 87 | MP0002282_abnormal_trachea_morphology | 1.02198204 |
| 88 | MP0002102_abnormal_ear_morphology | 1.02013947 |
| 89 | MP0010368_abnormal_lymphatic_system | 1.01747501 |
| 90 | MP0000778_abnormal_nervous_system | 0.99308074 |
| 91 | MP0000534_abnormal_ureter_morphology | 0.99292170 |
| 92 | MP0002086_abnormal_extraembryonic_tissu | 0.99163195 |
| 93 | MP0002092_abnormal_eye_morphology | 0.98933770 |
| 94 | MP0003786_premature_aging | 0.98057888 |
| 95 | MP0000428_abnormal_craniofacial_morphol | 0.93257517 |
| 96 | MP0003718_maternal_effect | 0.91584629 |
| 97 | MP0009250_abnormal_appendicular_skeleto | 0.91508901 |
| 98 | MP0001915_intracranial_hemorrhage | 0.91335177 |
| 99 | MP0000647_abnormal_sebaceous_gland | 0.88276881 |
| 100 | MP0004858_abnormal_nervous_system | 0.87384409 |
| 101 | MP0002925_abnormal_cardiovascular_devel | 0.87181758 |
| 102 | MP0001929_abnormal_gametogenesis | 0.86814062 |
| 103 | MP0002109_abnormal_limb_morphology | 0.84883681 |
| 104 | MP0000653_abnormal_sex_gland | 0.84112125 |
| 105 | MP0002081_perinatal_lethality | 0.83921021 |
| 106 | MP0002114_abnormal_axial_skeleton | 0.82849761 |
| 107 | MP0001270_distended_abdomen | 0.82739920 |
| 108 | MP0001145_abnormal_male_reproductive | 0.82157099 |
| 109 | MP0000313_abnormal_cell_death | 0.82019401 |
| 110 | MP0010234_abnormal_vibrissa_follicle | 0.80890251 |
| 111 | MP0002127_abnormal_cardiovascular_syste | 0.80542998 |
| 112 | MP0000631_abnormal_neuroendocrine_gland | 0.79504333 |
| 113 | MP0000015_abnormal_ear_pigmentation | 0.79144865 |
| 114 | MP0002210_abnormal_sex_determination | 0.78485782 |
| 115 | MP0008995_early_reproductive_senescence | 0.78394047 |
| 116 | MP0002098_abnormal_vibrissa_morphology | 0.76298296 |
| 117 | MP0009703_decreased_birth_body | 0.75925697 |
| 118 | MP0002152_abnormal_brain_morphology | 0.74965675 |
| 119 | MP0010678_abnormal_skin_adnexa | 0.74448651 |
| 120 | MP0005647_abnormal_sex_gland | 0.73108174 |
| 121 | MP0003699_abnormal_female_reproductive | 0.72450373 |
| 122 | MP0005195_abnormal_posterior_eye | 0.72264272 |
| 123 | MP0006054_spinal_hemorrhage | 0.71005619 |
| 124 | MP0001324_abnormal_eye_pigmentation | 0.70536810 |
| 125 | MP0006276_abnormal_autonomic_nervous | 0.70326717 |
| 126 | MP0004811_abnormal_neuron_physiology | 0.69351728 |
| 127 | MP0001984_abnormal_olfaction | 0.68640966 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.86927793 |
| 2 | Cortical dysplasia (HP:0002539) | 3.65228151 |
| 3 | Chromsome breakage (HP:0040012) | 3.62722151 |
| 4 | Abnormal lung lobation (HP:0002101) | 3.51466902 |
| 5 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.49034346 |
| 6 | Short 4th metacarpal (HP:0010044) | 3.49034346 |
| 7 | Patellar aplasia (HP:0006443) | 3.46052525 |
| 8 | Ectopic kidney (HP:0000086) | 3.44363336 |
| 9 | Birth length less than 3rd percentile (HP:0003561) | 3.38403725 |
| 10 | Abnormality of the anterior horn cell (HP:0006802) | 3.36024744 |
| 11 | Degeneration of anterior horn cells (HP:0002398) | 3.36024744 |
| 12 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.23492208 |
| 13 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 3.08183520 |
| 14 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.03080244 |
| 15 | Intestinal atresia (HP:0011100) | 3.02122163 |
| 16 | Embryonal renal neoplasm (HP:0011794) | 2.94075856 |
| 17 | Bilateral microphthalmos (HP:0007633) | 2.91499514 |
| 18 | Septo-optic dysplasia (HP:0100842) | 2.89798811 |
| 19 | Abnormal number of incisors (HP:0011064) | 2.88708425 |
| 20 | Syringomyelia (HP:0003396) | 2.84127557 |
| 21 | Spinal cord lesions (HP:0100561) | 2.84127557 |
| 22 | Anophthalmia (HP:0000528) | 2.79716493 |
| 23 | Short middle phalanx of the 5th finger (HP:0004220) | 2.69463708 |
| 24 | Meckel diverticulum (HP:0002245) | 2.61516871 |
| 25 | Hepatoblastoma (HP:0002884) | 2.60049759 |
| 26 | Abnormality of the intervertebral disk (HP:0005108) | 2.57811736 |
| 27 | Oligodactyly (hands) (HP:0001180) | 2.57554561 |
| 28 | Midline defect of the nose (HP:0004122) | 2.55261163 |
| 29 | Renal duplication (HP:0000075) | 2.51208401 |
| 30 | Abnormality of the ileum (HP:0001549) | 2.47065364 |
| 31 | Oligodactyly (HP:0012165) | 2.43439307 |
| 32 | Rhabdomyosarcoma (HP:0002859) | 2.41794957 |
| 33 | Abnormality of chromosome segregation (HP:0002916) | 2.41216823 |
| 34 | Trigonocephaly (HP:0000243) | 2.40542505 |
| 35 | Small intestinal stenosis (HP:0012848) | 2.40076304 |
| 36 | Duodenal stenosis (HP:0100867) | 2.40076304 |
| 37 | Abnormality of the aortic arch (HP:0012303) | 2.39865401 |
| 38 | Abnormality of the 4th metacarpal (HP:0010012) | 2.39833720 |
| 39 | Abnormality of the labia minora (HP:0012880) | 2.36056424 |
| 40 | Supernumerary spleens (HP:0009799) | 2.35522672 |
| 41 | Papillary thyroid carcinoma (HP:0002895) | 2.34175301 |
| 42 | Colon cancer (HP:0003003) | 2.33654366 |
| 43 | Optic nerve coloboma (HP:0000588) | 2.33636494 |
| 44 | Diastasis recti (HP:0001540) | 2.28879024 |
| 45 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.28776451 |
| 46 | Hypoplasia of the fovea (HP:0007750) | 2.28776451 |
| 47 | Optic nerve hypoplasia (HP:0000609) | 2.26678541 |
| 48 | Long eyelashes (HP:0000527) | 2.23943398 |
| 49 | Morphological abnormality of the middle ear (HP:0008609) | 2.23867443 |
| 50 | Abnormality of the septum pellucidum (HP:0007375) | 2.22621452 |
| 51 | Renal hypoplasia (HP:0000089) | 2.20859329 |
| 52 | Deep philtrum (HP:0002002) | 2.19158806 |
| 53 | Abnormality of the metopic suture (HP:0005556) | 2.15685828 |
| 54 | Volvulus (HP:0002580) | 2.15627962 |
| 55 | Asymmetry of the thorax (HP:0001555) | 2.14771961 |
| 56 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.14559787 |
| 57 | Absent eyebrow (HP:0002223) | 2.13256997 |
| 58 | Abnormality of the fovea (HP:0000493) | 2.13058021 |
| 59 | Selective tooth agenesis (HP:0001592) | 2.12753766 |
| 60 | Absent septum pellucidum (HP:0001331) | 2.12600230 |
| 61 | Long palpebral fissure (HP:0000637) | 2.12374833 |
| 62 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.12024580 |
| 63 | Hypoplastic pelvis (HP:0008839) | 2.11752016 |
| 64 | Split foot (HP:0001839) | 2.11188261 |
| 65 | Breast hypoplasia (HP:0003187) | 2.10361340 |
| 66 | Sloping forehead (HP:0000340) | 2.09410502 |
| 67 | Hypoplastic left heart (HP:0004383) | 2.09027893 |
| 68 | Abnormality of the duodenum (HP:0002246) | 2.05840898 |
| 69 | Hemivertebrae (HP:0002937) | 2.05695796 |
| 70 | Broad alveolar ridges (HP:0000187) | 2.05247726 |
| 71 | Medulloblastoma (HP:0002885) | 2.04579385 |
| 72 | Bifid tongue (HP:0010297) | 2.04318628 |
| 73 | Hyperglycinemia (HP:0002154) | 2.01787506 |
| 74 | Facial hemangioma (HP:0000329) | 2.01683339 |
| 75 | Dandy-Walker malformation (HP:0001305) | 2.00754302 |
| 76 | Abnormal pancreas size (HP:0012094) | 1.99107484 |
| 77 | Shawl scrotum (HP:0000049) | 1.95470909 |
| 78 | Gonadotropin excess (HP:0000837) | 1.95049885 |
| 79 | Progressive sensorineural hearing impairment (HP:0000408) | 1.94796481 |
| 80 | Vitreoretinal degeneration (HP:0000655) | 1.94762246 |
| 81 | Deviation of the thumb (HP:0009603) | 1.93738953 |
| 82 | Rib fusion (HP:0000902) | 1.93034273 |
| 83 | Abnormality of abdominal situs (HP:0011620) | 1.91224402 |
| 84 | Abdominal situs inversus (HP:0003363) | 1.91224402 |
| 85 | Increased nuchal translucency (HP:0010880) | 1.89306041 |
| 86 | Stenosis of the external auditory canal (HP:0000402) | 1.88912065 |
| 87 | Heterochromia iridis (HP:0001100) | 1.87991078 |
| 88 | Skull defect (HP:0001362) | 1.87723481 |
| 89 | Multiple enchondromatosis (HP:0005701) | 1.86378244 |
| 90 | Slow-growing hair (HP:0002217) | 1.86287678 |
| 91 | Abnormality of hair growth rate (HP:0011363) | 1.86287678 |
| 92 | Long clavicles (HP:0000890) | 1.85590518 |
| 93 | Abnormality of the carotid arteries (HP:0005344) | 1.85447181 |
| 94 | Bicornuate uterus (HP:0000813) | 1.85404480 |
| 95 | Myelomeningocele (HP:0002475) | 1.85330103 |
| 96 | Biliary tract neoplasm (HP:0100574) | 1.84240884 |
| 97 | Coarctation of aorta (HP:0001680) | 1.84140820 |
| 98 | Horseshoe kidney (HP:0000085) | 1.82792651 |
| 99 | Embryonal neoplasm (HP:0002898) | 1.82528339 |
| 100 | Micropenis (HP:0000054) | 1.82236346 |
| 101 | Atresia of the external auditory canal (HP:0000413) | 1.82069633 |
| 102 | Cutis marmorata (HP:0000965) | 1.81853205 |
| 103 | Abnormality of the incisor (HP:0000676) | 1.79731282 |
| 104 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.79369194 |
| 105 | Leiomyosarcoma (HP:0100243) | 1.79114915 |
| 106 | Uterine leiomyosarcoma (HP:0002891) | 1.79114915 |
| 107 | Proximal placement of thumb (HP:0009623) | 1.78651537 |
| 108 | Abnormality of chromosome stability (HP:0003220) | 1.77256036 |
| 109 | 11 pairs of ribs (HP:0000878) | 1.77070053 |
| 110 | Aqueductal stenosis (HP:0002410) | 1.76009123 |
| 111 | Amyotrophic lateral sclerosis (HP:0007354) | 1.75656407 |
| 112 | Pendular nystagmus (HP:0012043) | 1.75508192 |
| 113 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.75107827 |
| 114 | High anterior hairline (HP:0009890) | 1.74365838 |
| 115 | Neoplasm of striated muscle (HP:0009728) | 1.73547458 |
| 116 | Drooling (HP:0002307) | 1.73053415 |
| 117 | Abnormality of the parathyroid morphology (HP:0011766) | 1.72795495 |
| 118 | Tetralogy of Fallot (HP:0001636) | 1.72719841 |
| 119 | Congenital diaphragmatic hernia (HP:0000776) | 1.72677534 |
| 120 | Intestinal fistula (HP:0100819) | 1.71162799 |
| 121 | Overlapping toe (HP:0001845) | 1.71093462 |
| 122 | Abnormality of the preputium (HP:0100587) | 1.70381288 |
| 123 | Short 5th finger (HP:0009237) | 1.70315850 |
| 124 | Shoulder girdle muscle weakness (HP:0003547) | 1.69035305 |
| 125 | Absent radius (HP:0003974) | 1.68836891 |
| 126 | Growth hormone deficiency (HP:0000824) | 1.68783666 |
| 127 | Carpal bone hypoplasia (HP:0001498) | 1.68571978 |
| 128 | Short thumb (HP:0009778) | 1.68336050 |
| 129 | Broad foot (HP:0001769) | 1.68054841 |
| 130 | Gastrointestinal atresia (HP:0002589) | 1.67834386 |
| 131 | Postaxial foot polydactyly (HP:0001830) | 1.67643892 |
| 132 | Neoplasm of the colon (HP:0100273) | 1.66279376 |
| 133 | Abnormality of the fingertips (HP:0001211) | 1.66122638 |
| 134 | Hypoplastic heart (HP:0001961) | 1.65749304 |
| 135 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.64762069 |
| 136 | Ependymoma (HP:0002888) | 1.64628280 |
| 137 | Anal stenosis (HP:0002025) | 1.64315545 |
| 138 | Prominent metopic ridge (HP:0005487) | 1.64088645 |
| 139 | Preaxial hand polydactyly (HP:0001177) | 1.63848028 |
| 140 | Aplasia involving forearm bones (HP:0009822) | 1.63662466 |
| 141 | Absent forearm bone (HP:0003953) | 1.63662466 |
| 142 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.63565715 |
| 143 | Pancreatic fibrosis (HP:0100732) | 1.63396779 |
| 144 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.63106620 |
| 145 | Triphalangeal thumb (HP:0001199) | 1.62812431 |
| 146 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 1.62628096 |
| 147 | Anencephaly (HP:0002323) | 1.62526910 |
| 148 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.62378611 |
| 149 | Chin dimple (HP:0010751) | 1.61502582 |
| 150 | Thyroid carcinoma (HP:0002890) | 1.60589916 |
| 151 | Congenital primary aphakia (HP:0007707) | 1.60019413 |
| 152 | Cutaneous syndactyly (HP:0012725) | 1.59979377 |
| 153 | Gastrointestinal carcinoma (HP:0002672) | 1.59429045 |
| 154 | Neoplasm of the oral cavity (HP:0100649) | 1.58256229 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SRPK1 | 3.99309237 |
| 2 | MKNK1 | 3.49624775 |
| 3 | CDC7 | 3.28073558 |
| 4 | AKT3 | 3.24187695 |
| 5 | BUB1 | 2.81539679 |
| 6 | CCNB1 | 2.68863467 |
| 7 | TRIM28 | 2.67118254 |
| 8 | MAP3K4 | 2.58143185 |
| 9 | EIF2AK1 | 2.44519182 |
| 10 | SIK3 | 2.38533725 |
| 11 | WNK3 | 2.30748399 |
| 12 | TSSK6 | 2.21542001 |
| 13 | MKNK2 | 2.19692869 |
| 14 | EPHB2 | 2.17477723 |
| 15 | ERBB3 | 2.01579501 |
| 16 | WEE1 | 1.99802924 |
| 17 | PLK3 | 1.92426707 |
| 18 | LATS1 | 1.90132433 |
| 19 | STK24 | 1.86868363 |
| 20 | CDK12 | 1.83395190 |
| 21 | SGK2 | 1.83222558 |
| 22 | MAP3K10 | 1.82010337 |
| 23 | CDK8 | 1.80966363 |
| 24 | PASK | 1.74638069 |
| 25 | NUAK1 | 1.70240094 |
| 26 | TGFBR1 | 1.58678963 |
| 27 | TAF1 | 1.55488794 |
| 28 | CSNK1G3 | 1.55325513 |
| 29 | CSNK1A1L | 1.53137758 |
| 30 | ACVR1B | 1.52570062 |
| 31 | PRPF4B | 1.51469292 |
| 32 | CASK | 1.49918014 |
| 33 | CSNK1G1 | 1.48477581 |
| 34 | CHEK2 | 1.45658919 |
| 35 | ATR | 1.43450849 |
| 36 | NEK2 | 1.42801779 |
| 37 | KSR1 | 1.42770239 |
| 38 | PLK1 | 1.39294914 |
| 39 | YES1 | 1.37418715 |
| 40 | BRSK2 | 1.36530600 |
| 41 | BRSK1 | 1.35597857 |
| 42 | CSNK1G2 | 1.35408556 |
| 43 | BRAF | 1.33168143 |
| 44 | TTK | 1.29544019 |
| 45 | TNIK | 1.29244408 |
| 46 | VRK2 | 1.29060903 |
| 47 | CLK1 | 1.27061764 |
| 48 | CDK7 | 1.26295168 |
| 49 | BRD4 | 1.24419110 |
| 50 | NEK1 | 1.23189078 |
| 51 | TAOK2 | 1.17869531 |
| 52 | SGK3 | 1.15669666 |
| 53 | DYRK2 | 1.12892602 |
| 54 | STK3 | 1.12672550 |
| 55 | IRAK2 | 1.11184908 |
| 56 | STK38L | 1.10893290 |
| 57 | CDK19 | 1.08785090 |
| 58 | STK4 | 1.06896021 |
| 59 | MAPK13 | 1.04188153 |
| 60 | AURKB | 1.03665908 |
| 61 | VRK1 | 1.03425520 |
| 62 | CAMK1D | 1.01607461 |
| 63 | MAP3K9 | 0.99920151 |
| 64 | CHEK1 | 0.98731979 |
| 65 | CDK4 | 0.98444257 |
| 66 | MAP4K2 | 0.98267841 |
| 67 | MARK1 | 0.97730285 |
| 68 | SGK223 | 0.97642508 |
| 69 | SGK494 | 0.97642508 |
| 70 | MELK | 0.91380966 |
| 71 | PLK4 | 0.89534821 |
| 72 | TLK1 | 0.86739228 |
| 73 | BCR | 0.86129243 |
| 74 | CAMK1G | 0.82544919 |
| 75 | EIF2AK2 | 0.81935328 |
| 76 | TIE1 | 0.81747507 |
| 77 | PBK | 0.80526802 |
| 78 | DYRK1B | 0.76938977 |
| 79 | CDK3 | 0.76463352 |
| 80 | CDK1 | 0.75445305 |
| 81 | PIM1 | 0.74512598 |
| 82 | CDK2 | 0.73568444 |
| 83 | PLK2 | 0.73161491 |
| 84 | ATM | 0.68815106 |
| 85 | AURKA | 0.62777341 |
| 86 | MAP2K7 | 0.62388690 |
| 87 | CHUK | 0.61690380 |
| 88 | ZAK | 0.61024229 |
| 89 | RPS6KA4 | 0.60805841 |
| 90 | LATS2 | 0.56063746 |
| 91 | CSNK1E | 0.55057668 |
| 92 | FGFR1 | 0.54798016 |
| 93 | CDK14 | 0.54589412 |
| 94 | RPS6KB1 | 0.54296571 |
| 95 | CDK18 | 0.53398064 |
| 96 | CDK9 | 0.51954298 |
| 97 | INSRR | 0.51446145 |
| 98 | PIM2 | 0.49104998 |
| 99 | CDK6 | 0.48381365 |
| 100 | MAP3K8 | 0.48081815 |
| 101 | DYRK3 | 0.47450218 |
| 102 | BMPR1B | 0.46526015 |
| 103 | NEK6 | 0.46135783 |
| 104 | EIF2AK3 | 0.46061207 |
| 105 | MINK1 | 0.45785931 |
| 106 | UHMK1 | 0.45506069 |
| 107 | MAP3K14 | 0.45252976 |
| 108 | CDK15 | 0.44941594 |
| 109 | RPS6KL1 | 0.44822444 |
| 110 | RPS6KC1 | 0.44822444 |
| 111 | MAP3K5 | 0.44680768 |
| 112 | MAP2K4 | 0.44177678 |
| 113 | CDK11A | 0.43589214 |
| 114 | MAPK14 | 0.43338697 |
| 115 | MARK3 | 0.42652301 |
| 116 | STK10 | 0.41807178 |
| 117 | ARAF | 0.40722935 |
| 118 | MATK | 0.40568952 |
| 119 | CSNK2A1 | 0.39651666 |
| 120 | EEF2K | 0.38914943 |
| 121 | TAOK1 | 0.38803384 |
| 122 | MAP2K6 | 0.38686744 |
| 123 | RPS6KA2 | 0.38539405 |
| 124 | RPS6KA6 | 0.38003626 |
| 125 | AKT2 | 0.37835636 |
| 126 | AKT1 | 0.37057096 |
| 127 | EPHA4 | 0.36585984 |
| 128 | CSNK1D | 0.36533171 |
| 129 | NTRK2 | 0.35282848 |
| 130 | NEK9 | 0.34947037 |
| 131 | DMPK | 0.34216264 |
| 132 | DYRK1A | 0.34140133 |
| 133 | CSNK2A2 | 0.32366535 |
| 134 | IRAK1 | 0.31587959 |
| 135 | PAK4 | 0.30446637 |
| 136 | GSK3B | 0.29584943 |
| 137 | PRKDC | 0.29493999 |
| 138 | MAP4K1 | 0.28334374 |
| 139 | ALK | 0.27694764 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 3.45647194 |
| 2 | Steroid biosynthesis_Homo sapiens_hsa00100 | 3.42601540 |
| 3 | Spliceosome_Homo sapiens_hsa03040 | 3.34033264 |
| 4 | Cell cycle_Homo sapiens_hsa04110 | 3.32276622 |
| 5 | Base excision repair_Homo sapiens_hsa03410 | 2.91271053 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.90886328 |
| 7 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.87747707 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.76084002 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.75755765 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.64451846 |
| 11 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.60603887 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.34859235 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 2.23156849 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.17282001 |
| 15 | Protein export_Homo sapiens_hsa03060 | 2.11878933 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.03666718 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.96220621 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.91776843 |
| 19 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.90506062 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.86582528 |
| 21 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.73733351 |
| 22 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.62006013 |
| 23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.60112396 |
| 24 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.55727701 |
| 25 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.52339502 |
| 26 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.48540708 |
| 27 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.48041312 |
| 28 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.44602159 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.44266230 |
| 30 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.43206117 |
| 31 | Proteasome_Homo sapiens_hsa03050 | 1.41384208 |
| 32 | Colorectal cancer_Homo sapiens_hsa05210 | 1.38993778 |
| 33 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.37777733 |
| 34 | Endometrial cancer_Homo sapiens_hsa05213 | 1.36741834 |
| 35 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.36504907 |
| 36 | Thyroid cancer_Homo sapiens_hsa05216 | 1.31993237 |
| 37 | HTLV-I infection_Homo sapiens_hsa05166 | 1.28394726 |
| 38 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.27179724 |
| 39 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.25459965 |
| 40 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.24564747 |
| 41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.16602917 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.15722674 |
| 43 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.13238650 |
| 44 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.10277900 |
| 45 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.07528468 |
| 46 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.05963263 |
| 47 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.04501618 |
| 48 | Purine metabolism_Homo sapiens_hsa00230 | 1.04091431 |
| 49 | Adherens junction_Homo sapiens_hsa04520 | 1.02534039 |
| 50 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.01770582 |
| 51 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.99830941 |
| 52 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.99361261 |
| 53 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.98740627 |
| 54 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.97009904 |
| 55 | Hepatitis B_Homo sapiens_hsa05161 | 0.94636962 |
| 56 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.94345800 |
| 57 | Influenza A_Homo sapiens_hsa05164 | 0.89229739 |
| 58 | Prostate cancer_Homo sapiens_hsa05215 | 0.89080562 |
| 59 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.87873086 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.85179972 |
| 61 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.79323086 |
| 62 | Viral myocarditis_Homo sapiens_hsa05416 | 0.79319147 |
| 63 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.76772348 |
| 64 | Axon guidance_Homo sapiens_hsa04360 | 0.75760668 |
| 65 | Pathways in cancer_Homo sapiens_hsa05200 | 0.74716045 |
| 66 | Measles_Homo sapiens_hsa05162 | 0.73971924 |
| 67 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.72982199 |
| 68 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.72396587 |
| 69 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.72260797 |
| 70 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.69777623 |
| 71 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.69398822 |
| 72 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.67064176 |
| 73 | Lysine degradation_Homo sapiens_hsa00310 | 0.63942671 |
| 74 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.63605182 |
| 75 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.62134757 |
| 76 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.62114023 |
| 77 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.60669064 |
| 78 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.58722382 |
| 79 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.57520434 |
| 80 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57501934 |
| 81 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.57009857 |
| 82 | Shigellosis_Homo sapiens_hsa05131 | 0.56939919 |
| 83 | Apoptosis_Homo sapiens_hsa04210 | 0.55973848 |
| 84 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.55764266 |
| 85 | Alcoholism_Homo sapiens_hsa05034 | 0.55732231 |
| 86 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.55051681 |
| 87 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.53888655 |
| 88 | Melanoma_Homo sapiens_hsa05218 | 0.53478511 |
| 89 | Ribosome_Homo sapiens_hsa03010 | 0.52121206 |
| 90 | Phototransduction_Homo sapiens_hsa04744 | 0.51204692 |
| 91 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.51002767 |
| 92 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.48290989 |
| 93 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.48032053 |
| 94 | Huntingtons disease_Homo sapiens_hsa05016 | 0.45447342 |
| 95 | Nicotine addiction_Homo sapiens_hsa05033 | 0.45353481 |
| 96 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.45280667 |
| 97 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.41732824 |
| 98 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.41281188 |
| 99 | Legionellosis_Homo sapiens_hsa05134 | 0.40320935 |
| 100 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.39596114 |
| 101 | Melanogenesis_Homo sapiens_hsa04916 | 0.38590914 |
| 102 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.37610325 |
| 103 | Bladder cancer_Homo sapiens_hsa05219 | 0.37442702 |
| 104 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.37377787 |
| 105 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.37141166 |
| 106 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.37082352 |
| 107 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.35831260 |
| 108 | Tight junction_Homo sapiens_hsa04530 | 0.35372677 |
| 109 | Hepatitis C_Homo sapiens_hsa05160 | 0.34564536 |
| 110 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.34063607 |
| 111 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.32543168 |
| 112 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.32180563 |
| 113 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.31642210 |
| 114 | Carbon metabolism_Homo sapiens_hsa01200 | 0.30204167 |
| 115 | Glioma_Homo sapiens_hsa05214 | 0.30026817 |
| 116 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.28895355 |
| 117 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.28752447 |
| 118 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.27325519 |
| 119 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.27111474 |
| 120 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.26908191 |
| 121 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.26216112 |
| 122 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.25051263 |
| 123 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.24218708 |
| 124 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.24182349 |
| 125 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.23215097 |
| 126 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.19529775 |
| 127 | Gap junction_Homo sapiens_hsa04540 | 0.18968841 |
| 128 | Metabolic pathways_Homo sapiens_hsa01100 | 0.18750998 |
| 129 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.18232793 |
| 130 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.17986250 |
| 131 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.17696792 |
| 132 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.17270429 |
| 133 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.15229853 |
| 134 | Parkinsons disease_Homo sapiens_hsa05012 | 0.13774855 |
| 135 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.13081045 |

