CCNJL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.02410635
2positive regulation by organism of defense response of other organism involved in symbiotic interact7.02410635
3modulation by symbiont of host immune response (GO:0052553)7.02410635
4positive regulation by symbiont of host defense response (GO:0052509)7.02410635
5modulation by symbiont of host defense response (GO:0052031)7.02410635
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.02410635
7neutrophil activation involved in immune response (GO:0002283)6.49310663
8leukocyte migration involved in inflammatory response (GO:0002523)6.46672434
9antigen processing and presentation via MHC class Ib (GO:0002475)6.19374430
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.96977312
11paraxial mesoderm development (GO:0048339)5.45383702
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.44457119
13neutrophil activation (GO:0042119)5.37604927
14antigen processing and presentation of endogenous antigen (GO:0019883)5.37261182
15negative regulation of cell killing (GO:0031342)5.03021257
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.03021257
17macrophage activation involved in immune response (GO:0002281)4.96496445
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.82979530
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80850999
20DNA strand renaturation (GO:0000733)4.78688347
21regulation of interferon-beta biosynthetic process (GO:0045357)4.78483626
22response to host immune response (GO:0052572)4.68295405
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.68295405
24granulocyte activation (GO:0036230)4.62972560
25respiratory burst (GO:0045730)4.48466830
26detection of molecule of bacterial origin (GO:0032490)4.41130008
27leukocyte aggregation (GO:0070486)4.38363946
28central nervous system myelination (GO:0022010)4.37862393
29axon ensheathment in central nervous system (GO:0032291)4.37862393
30negative regulation of phagocytosis (GO:0050765)4.28398589
31response to interleukin-15 (GO:0070672)4.25327980
32response to host (GO:0075136)4.24395867
33response to host defenses (GO:0052200)4.24395867
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.24395867
35detection of other organism (GO:0098543)4.15149471
36cellular response to interleukin-15 (GO:0071350)4.12720278
37microglial cell activation (GO:0001774)4.12421757
38negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.07637443
39regulation of posttranscriptional gene silencing (GO:0060147)4.06587001
40regulation of gene silencing by miRNA (GO:0060964)4.06587001
41regulation of gene silencing by RNA (GO:0060966)4.06587001
42cellular extravasation (GO:0045123)3.92142776
43positive regulation of mast cell activation (GO:0033005)3.83138515
44detection of external biotic stimulus (GO:0098581)3.80469446
45myeloid cell activation involved in immune response (GO:0002275)3.73579879
46neutrophil mediated immunity (GO:0002446)3.70765307
47detection of bacterium (GO:0016045)3.65219225
48production of molecular mediator involved in inflammatory response (GO:0002532)3.60625505
49kinetochore assembly (GO:0051382)3.60033773
50response to peptidoglycan (GO:0032494)3.59533674
51DNA unwinding involved in DNA replication (GO:0006268)3.53905251
52kinetochore organization (GO:0051383)3.50384424
53regulation of B cell receptor signaling pathway (GO:0050855)3.48609949
54macrophage activation (GO:0042116)3.45780776
55thrombin receptor signaling pathway (GO:0070493)3.45353136
56heterochromatin organization (GO:0070828)3.44751209
57leukocyte degranulation (GO:0043299)3.43610148
58detection of biotic stimulus (GO:0009595)3.42618883
59dendritic cell migration (GO:0036336)3.39775118
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.39668098
61mitotic metaphase plate congression (GO:0007080)3.38918684
62negative regulation of B cell proliferation (GO:0030889)3.38043223
63dendritic cell chemotaxis (GO:0002407)3.37600751
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.36444802
65positive regulation of interleukin-8 secretion (GO:2000484)3.35473763
66B cell mediated immunity (GO:0019724)3.34422590
67determination of adult lifespan (GO:0008340)3.34089403
68positive regulation of toll-like receptor signaling pathway (GO:0034123)3.30854680
69establishment of integrated proviral latency (GO:0075713)3.29354296
70regulation of interleukin-6 biosynthetic process (GO:0045408)3.15582797
71regulation of exit from mitosis (GO:0007096)3.15302889
72apical protein localization (GO:0045176)3.14017511
73regulation of B cell differentiation (GO:0045577)3.13849362
74regulation of mast cell degranulation (GO:0043304)3.08120955
75immunoglobulin mediated immune response (GO:0016064)3.07460226
76positive regulation of Cdc42 GTPase activity (GO:0043089)3.06822391
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06740718
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.06475321
79positive regulation of mast cell degranulation (GO:0043306)3.06475321
80adaptation of signaling pathway (GO:0023058)3.02243066
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01089774
82negative regulation of T-helper cell differentiation (GO:0045623)3.01089774
83pantothenate metabolic process (GO:0015939)3.00792640
84metaphase plate congression (GO:0051310)3.00420416
85myelination (GO:0042552)2.98734123
86positive regulation of gamma-delta T cell activation (GO:0046645)2.98402168
87axon ensheathment (GO:0008366)2.97313036
88ensheathment of neurons (GO:0007272)2.97313036
89myeloid leukocyte mediated immunity (GO:0002444)2.97269271
90protein localization to kinetochore (GO:0034501)2.95959099
91positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.95917212
92phagocytosis, engulfment (GO:0006911)2.93615279
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92238127
94regulation of cardioblast differentiation (GO:0051890)2.92184399
95CENP-A containing nucleosome assembly (GO:0034080)2.90630835
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89752389
97regulation of translation, ncRNA-mediated (GO:0045974)2.89194480
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.89194480
99negative regulation of translation, ncRNA-mediated (GO:0040033)2.89194480
100regulation of DNA methylation (GO:0044030)2.86689148
101positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.85051278
102regulation of mast cell activation involved in immune response (GO:0033006)2.84052828
103negative regulation of interleukin-12 production (GO:0032695)2.82546038
104positive regulation of interferon-alpha production (GO:0032727)2.80973724
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80953806
106regulation of leukocyte degranulation (GO:0043300)2.80947301
107positive regulation of B cell differentiation (GO:0045579)2.80748531
108chromatin remodeling at centromere (GO:0031055)2.78559568
109somite development (GO:0061053)2.77664779
110positive regulation of regulated secretory pathway (GO:1903307)2.76426846
111negative regulation of interleukin-1 production (GO:0032692)2.75243348
112mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74200950
113protein neddylation (GO:0045116)2.72455759
114regulation of mast cell activation (GO:0033003)2.71512808
115lateral sprouting from an epithelium (GO:0060601)2.71400515
116asymmetric protein localization (GO:0008105)2.71133960
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69599942
118protein localization to chromosome, centromeric region (GO:0071459)2.68412906
119negative regulation of leukocyte mediated immunity (GO:0002704)2.67725540
120embryonic hindlimb morphogenesis (GO:0035116)2.67360855
121regulation of somitogenesis (GO:0014807)2.66771005
122negative regulation of interleukin-6 production (GO:0032715)2.66270296
123positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.64920859
124positive regulation of cell cycle G2/M phase transition (GO:1902751)2.64920859
125pre-miRNA processing (GO:0031054)2.64495209
126enteric nervous system development (GO:0048484)2.64394653
127neutrophil chemotaxis (GO:0030593)2.64237382
128regulation of regulated secretory pathway (GO:1903305)2.62971286
129viral mRNA export from host cell nucleus (GO:0046784)2.62881898
130positive regulation of cell cycle checkpoint (GO:1901978)2.62700618
131mesenchymal cell proliferation (GO:0010463)2.61945399
132regulation of stem cell maintenance (GO:2000036)2.61845412
133negative regulation of alpha-beta T cell activation (GO:0046636)2.61157890
134DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.57169789
135hindlimb morphogenesis (GO:0035137)2.56398426
136embryonic foregut morphogenesis (GO:0048617)2.56153507
137establishment of mitotic spindle orientation (GO:0000132)2.55525822
138establishment of tissue polarity (GO:0007164)2.54806032
139establishment of planar polarity (GO:0001736)2.54806032
140establishment of mitotic spindle localization (GO:0040001)2.50325530
141neuronal stem cell maintenance (GO:0097150)2.48846691
142DNA ligation (GO:0006266)2.48251829
143protein-DNA complex disassembly (GO:0032986)2.47904479
144nucleosome disassembly (GO:0006337)2.47904479
145DNA damage response, signal transduction resulting in transcription (GO:0042772)2.46128046
146spliceosomal complex assembly (GO:0000245)2.45128445
147notochord development (GO:0030903)2.43956734
148fatty acid elongation (GO:0030497)2.42689312
149meiotic chromosome segregation (GO:0045132)2.42614905
150histone exchange (GO:0043486)2.42602468
151mitotic chromosome condensation (GO:0007076)2.40408041
152establishment of viral latency (GO:0019043)2.39916037
153negative regulation of striated muscle cell apoptotic process (GO:0010664)2.39588743
154DNA replication-independent nucleosome organization (GO:0034724)2.37354827
155DNA replication-independent nucleosome assembly (GO:0006336)2.37354827
156nephron tubule formation (GO:0072079)2.36655709
157mesenchyme development (GO:0060485)2.35919907
158spindle checkpoint (GO:0031577)2.35732505
159cranial nerve morphogenesis (GO:0021602)2.35648952
160positive regulation of actin filament depolymerization (GO:0030836)2.35256511
161single strand break repair (GO:0000012)2.34274019
162establishment of chromosome localization (GO:0051303)2.33552260
163mitotic spindle checkpoint (GO:0071174)2.31222820
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30675018
165viral transcription (GO:0019083)2.29532406
166epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.28488221
167heart valve formation (GO:0003188)2.27794735
168mitotic sister chromatid segregation (GO:0000070)2.26681744
169regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.26414083
170DNA damage response, detection of DNA damage (GO:0042769)2.26401468
171negative regulation of mRNA processing (GO:0050686)2.25673805
172cholesterol biosynthetic process (GO:0006695)2.24866976
173regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.24721688
174ribosomal small subunit biogenesis (GO:0042274)2.21911973
175establishment of spindle orientation (GO:0051294)2.21498083
176atrial cardiac muscle cell action potential (GO:0086014)2.20987318
177ATP-dependent chromatin remodeling (GO:0043044)2.20906042
178negative regulation of axon extension involved in axon guidance (GO:0048843)2.20880823
179RNA splicing, via transesterification reactions (GO:0000375)2.20764536
180mitotic spindle assembly checkpoint (GO:0007094)2.20361222
181cardiac myofibril assembly (GO:0055003)2.19292462
182RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.19127644
183mRNA splicing, via spliceosome (GO:0000398)2.19127644
184negative regulation of mitotic sister chromatid separation (GO:2000816)2.18848274
185negative regulation of mitotic sister chromatid segregation (GO:0033048)2.18848274
186negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.18848274
187negative regulation of sister chromatid segregation (GO:0033046)2.18848274
188translational termination (GO:0006415)2.18199849
189histone H2A acetylation (GO:0043968)2.18178374
190regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.17837589
191regulation of mitotic spindle checkpoint (GO:1903504)2.17837589
192cerebral cortex radially oriented cell migration (GO:0021799)2.17616489
193heart contraction (GO:0060047)2.17238214
194heart process (GO:0003015)2.17238214
195microtubule polymerization or depolymerization (GO:0031109)2.16713057
196endocardial cushion development (GO:0003197)2.16440137
197sister chromatid segregation (GO:0000819)2.16434289
198sympathetic nervous system development (GO:0048485)2.15768830
199ventricular septum morphogenesis (GO:0060412)2.15764675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.17896424
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.16134172
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.99894240
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.71189315
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34162205
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26721181
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14017927
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01146028
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96542904
10SPI1_23547873_ChIP-Seq_NB4_Human2.81608985
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70301115
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65558971
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65025226
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.62411506
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.54994797
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.41153702
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27776249
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27662708
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.27156274
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.21727749
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15928980
22SPI1_23127762_ChIP-Seq_K562_Human2.15670970
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.15261673
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11454883
25POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09615822
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.08529801
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07420980
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04830324
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.01984282
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.01558423
31AR_21909140_ChIP-Seq_LNCAP_Human2.01169523
32CBX2_27304074_Chip-Seq_ESCs_Mouse2.00887768
33SOX2_16153702_ChIP-ChIP_HESCs_Human2.00682155
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00021683
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97046874
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94611763
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91022784
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90468283
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88099893
40XRN2_22483619_ChIP-Seq_HELA_Human1.87489004
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86782387
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86166073
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.85983035
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82793075
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82793075
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82793075
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82691382
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81138450
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80678168
50VDR_24763502_ChIP-Seq_THP-1_Human1.78009470
51UTX_26944678_Chip-Seq_JUKART_Human1.77999335
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.76618430
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.75349750
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73996395
55MAF_26560356_Chip-Seq_TH1_Human1.73607890
56FUS_26573619_Chip-Seq_HEK293_Human1.72018415
57* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70085806
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.63833050
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63676230
60TTF2_22483619_ChIP-Seq_HELA_Human1.63229115
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.62817182
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60604147
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59917213
64TCF7_22412390_ChIP-Seq_EML_Mouse1.59092201
65RUNX_20019798_ChIP-Seq_JUKART_Human1.58770801
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56607415
67SCL_19346495_ChIP-Seq_HPC-7_Human1.53507367
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53173568
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.52643468
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51281838
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51226270
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49609243
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47784277
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46895887
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46463131
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46347574
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45247407
78MYB_26560356_Chip-Seq_TH2_Human1.45244056
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44945257
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.44108431
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43115439
82* ISL1_27105846_Chip-Seq_CPCs_Mouse1.43019202
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42336015
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41818944
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41264655
86* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41181156
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40745635
88RNF2_27304074_Chip-Seq_NSC_Mouse1.39743481
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37886319
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37291512
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37090337
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36146295
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33859555
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32720176
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.32703213
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32314702
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32243238
98MYC_22102868_ChIP-Seq_BL_Human1.30452402
99MYB_26560356_Chip-Seq_TH1_Human1.30439909
100EWS_26573619_Chip-Seq_HEK293_Human1.28391503
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.27173279
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25794762
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25794762
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25334033
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.23949518
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22639996
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22261568
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20511593
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20311058
110* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19794521
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19747484
112RING1B_27294783_Chip-Seq_NPCs_Mouse1.19310562
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17540169
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16415688
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16290619
116NANOG_16153702_ChIP-ChIP_HESCs_Human1.15331295
117MYC_18940864_ChIP-ChIP_HL60_Human1.14881229
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14504898
119NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13555976
120SOX9_26525672_Chip-Seq_HEART_Mouse1.13105392
121VDR_21846776_ChIP-Seq_THP-1_Human1.12506566
122KDM2B_26808549_Chip-Seq_DND41_Human1.11851744
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09974638
124ELK3_25401928_ChIP-Seq_HUVEC_Human1.09116919
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08983830
126MAF_26560356_Chip-Seq_TH2_Human1.07787006
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07128982
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06713993
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06175831
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05983538
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05288727
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03835894
133SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03647731
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03524573
135SOX17_20123909_ChIP-Seq_XEN_Mouse1.03088580
136* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02937731
137RNF2_27304074_Chip-Seq_ESCs_Mouse1.02216559
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01216558
139NANOG_20526341_ChIP-Seq_ESCs_Human1.00275676
140JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00232836
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00006450
142POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99288094
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97886244
144ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97652458
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.97418766
146NANOG_21062744_ChIP-ChIP_HESCs_Human0.97238592
147RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96735093
148EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96403460
149E2F1_21310950_ChIP-Seq_MCF-7_Human0.96240927
150NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95265259
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.94956975
152GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94665402
153* GATA3_27048872_Chip-Seq_THYMUS_Human0.94307082
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94057572
155RING1B_27294783_Chip-Seq_ESCs_Mouse0.93842088
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93461874
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92949544
158TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92792475
159SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92454534
160E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91983848
161SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90503656
162POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89198343
163SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88759493
164* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88317882
165STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87753510
166EZH2_27294783_Chip-Seq_ESCs_Mouse0.87737175
167POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86770785
168MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85849217
169* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85072659
170YY1_21170310_ChIP-Seq_MESCs_Mouse0.85023791
171* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84770468
172ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84042641
173TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82655159
174POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82655159
175GATA1_26923725_Chip-Seq_HPCs_Mouse0.81876970
176CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81165345
177TP53_20018659_ChIP-ChIP_R1E_Mouse0.81112608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.57530428
2MP0002653_abnormal_ependyma_morphology3.54636990
3MP0005464_abnormal_platelet_physiology2.90311500
4MP0010030_abnormal_orbit_morphology2.86639876
5MP0003436_decreased_susceptibility_to2.76951262
6MP0001835_abnormal_antigen_presentation2.58445502
7MP0003122_maternal_imprinting2.53943169
8MP0003123_paternal_imprinting2.53150256
9MP0002277_abnormal_respiratory_mucosa2.51466769
10MP0003937_abnormal_limbs/digits/tail_de2.33931033
11MP0003303_peritoneal_inflammation2.33371182
12MP0002254_reproductive_system_inflammat2.20480890
13MP0008260_abnormal_autophagy2.20369051
14MP0000566_synostosis2.20349420
15MP0003121_genomic_imprinting2.18117085
16MP0002419_abnormal_innate_immunity2.16548963
17MP0008057_abnormal_DNA_replication2.07848087
18MP0001485_abnormal_pinna_reflex2.01116327
19MP0000537_abnormal_urethra_morphology2.00869909
20MP0000049_abnormal_middle_ear1.98069665
21MP0008877_abnormal_DNA_methylation1.95776054
22MP0002938_white_spotting1.92682588
23MP0003385_abnormal_body_wall1.90947637
24MP0009053_abnormal_anal_canal1.89921703
25MP0002102_abnormal_ear_morphology1.88499418
26MP0005671_abnormal_response_to1.88395102
27MP0003878_abnormal_ear_physiology1.88023689
28MP0005377_hearing/vestibular/ear_phenot1.88023689
29MP0002132_abnormal_respiratory_system1.81540645
30MP0000685_abnormal_immune_system1.80575596
31MP0003315_abnormal_perineum_morphology1.76921721
32MP0005025_abnormal_response_to1.72345563
33MP0003119_abnormal_digestive_system1.72232350
34MP0003111_abnormal_nucleus_morphology1.70276041
35MP0003938_abnormal_ear_development1.69452437
36MP0008932_abnormal_embryonic_tissue1.69379553
37MP0003077_abnormal_cell_cycle1.67910337
38MP0001819_abnormal_immune_cell1.67237003
39MP0003828_pulmonary_edema1.66947067
40MP0003890_abnormal_embryonic-extraembry1.66550360
41MP0001293_anophthalmia1.66241532
42MP0008007_abnormal_cellular_replicative1.66179547
43MP0002420_abnormal_adaptive_immunity1.65838909
44MP0003566_abnormal_cell_adhesion1.64895002
45MP0001188_hyperpigmentation1.64811126
46MP0001730_embryonic_growth_arrest1.64103988
47MP0002396_abnormal_hematopoietic_system1.63061633
48MP0009250_abnormal_appendicular_skeleto1.60853982
49MP0004957_abnormal_blastocyst_morpholog1.53605681
50MP0010094_abnormal_chromosome_stability1.51170691
51MP0002249_abnormal_larynx_morphology1.50844297
52MP0008789_abnormal_olfactory_epithelium1.50379904
53MP0002085_abnormal_embryonic_tissue1.49748901
54MP0002723_abnormal_immune_serum1.49238232
55MP0009278_abnormal_bone_marrow1.48645043
56MP0002751_abnormal_autonomic_nervous1.47342250
57MP0001529_abnormal_vocalization1.47173322
58MP0000778_abnormal_nervous_system1.46099455
59MP0006292_abnormal_olfactory_placode1.45016824
60MP0001800_abnormal_humoral_immune1.45015157
61MP0002932_abnormal_joint_morphology1.42862858
62MP0003861_abnormal_nervous_system1.42185099
63MP0000462_abnormal_digestive_system1.41355611
64MP0004272_abnormal_basement_membrane1.40814295
65MP0000490_abnormal_crypts_of1.40608491
66MP0003866_abnormal_defecation1.39605050
67MP0002452_abnormal_antigen_presenting1.38316251
68MP0003942_abnormal_urinary_system1.38280769
69MP0003693_abnormal_embryo_hatching1.36563665
70MP0000465_gastrointestinal_hemorrhage1.36232476
71MP0002398_abnormal_bone_marrow1.34551573
72MP0003567_abnormal_fetal_cardiomyocyte1.34374522
73MP0005387_immune_system_phenotype1.34246230
74MP0001790_abnormal_immune_system1.34246230
75MP0000762_abnormal_tongue_morphology1.33694524
76MP0003191_abnormal_cellular_cholesterol1.33273581
77MP0001533_abnormal_skeleton_physiology1.33110150
78MP0009672_abnormal_birth_weight1.31557445
79MP0005451_abnormal_body_composition1.30075918
80MP0008058_abnormal_DNA_repair1.28923489
81MP0002233_abnormal_nose_morphology1.28707143
82MP0003115_abnormal_respiratory_system1.28649372
83MP0002084_abnormal_developmental_patter1.28263661
84MP0003755_abnormal_palate_morphology1.27676509
85MP0000703_abnormal_thymus_morphology1.27363570
86MP0003935_abnormal_craniofacial_develop1.27127411
87MP0005623_abnormal_meninges_morphology1.24442268
88MP0000716_abnormal_immune_system1.23597770
89MP0004084_abnormal_cardiac_muscle1.23026314
90MP0009785_altered_susceptibility_to1.23008003
91MP0000858_altered_metastatic_potential1.22988641
92MP0010368_abnormal_lymphatic_system1.21512624
93MP0002127_abnormal_cardiovascular_syste1.21237802
94MP0005380_embryogenesis_phenotype1.19070645
95MP0001672_abnormal_embryogenesis/_devel1.19070645
96MP0001697_abnormal_embryo_size1.18864622
97MP0000534_abnormal_ureter_morphology1.18841066
98MP0006138_congestive_heart_failure1.18111258
99MP0004133_heterotaxia1.17315024
100MP0002722_abnormal_immune_system1.16322372
101MP0001286_abnormal_eye_development1.15866607
102MP0006082_CNS_inflammation1.14865392
103MP0002116_abnormal_craniofacial_bone1.12709374
104MP0000689_abnormal_spleen_morphology1.11530861
105MP0002429_abnormal_blood_cell1.10598833
106MP0000350_abnormal_cell_proliferation1.09423818
107MP0005000_abnormal_immune_tolerance1.07755786
108MP0005171_absent_coat_pigmentation1.07516392
109MP0002111_abnormal_tail_morphology1.07133463
110MP0001346_abnormal_lacrimal_gland1.05868241
111MP0000428_abnormal_craniofacial_morphol1.05824372
112MP0005084_abnormal_gallbladder_morpholo1.04934383
113MP0003984_embryonic_growth_retardation1.04415919
114MP0000613_abnormal_salivary_gland1.04328510
115MP0005499_abnormal_olfactory_system1.03806440
116MP0005394_taste/olfaction_phenotype1.03806440
117MP0002752_abnormal_somatic_nervous1.03452449
118MP0001849_ear_inflammation1.02928070
119MP0005083_abnormal_biliary_tract1.02700087
120MP0009764_decreased_sensitivity_to1.02360458
121MP0002088_abnormal_embryonic_growth/wei1.01606277
122MP0000026_abnormal_inner_ear1.01599465
123MP0002405_respiratory_system_inflammati1.01388701
124MP0003283_abnormal_digestive_organ1.00952455
125MP0000516_abnormal_urinary_system1.00010115
126MP0005367_renal/urinary_system_phenotyp1.00010115
127MP0002697_abnormal_eye_size0.98664452
128MP0004381_abnormal_hair_follicle0.97949011
129MP0000631_abnormal_neuroendocrine_gland0.97313188
130MP0003137_abnormal_impulse_conducting0.96946512
131MP0004197_abnormal_fetal_growth/weight/0.96781134
132MP0004233_abnormal_muscle_weight0.96284359
133MP0003941_abnormal_skin_development0.96199602
134MP0002092_abnormal_eye_morphology0.95811114
135MP0002114_abnormal_axial_skeleton0.95326948
136MP0002282_abnormal_trachea_morphology0.95295216
137MP0002148_abnormal_hypersensitivity_rea0.95157328
138MP0005409_darkened_coat_color0.95059062
139MP0004883_abnormal_blood_vessel0.94671613
140MP0000432_abnormal_head_morphology0.93585320
141MP0004510_myositis0.93417526
142MP0000383_abnormal_hair_follicle0.92797828
143MP0002638_abnormal_pupillary_reflex0.91139138
144MP0010155_abnormal_intestine_physiology0.90866269
145MP0003787_abnormal_imprinting0.90418864
146MP0001851_eye_inflammation0.89731907
147MP0002152_abnormal_brain_morphology0.89601340
148MP0003183_abnormal_peptide_metabolism0.88818554
149MP0005248_abnormal_Harderian_gland0.88292501
150MP0009703_decreased_birth_body0.87886034
151MP0005391_vision/eye_phenotype0.85563123
152MP0001879_abnormal_lymphatic_vessel0.85308001
153MP0003943_abnormal_hepatobiliary_system0.85296763
154MP0001663_abnormal_digestive_system0.83125980
155MP0001845_abnormal_inflammatory_respons0.82741291
156MP0008004_abnormal_stomach_pH0.81005485
157MP0003448_altered_tumor_morphology0.80791546
158MP0002086_abnormal_extraembryonic_tissu0.76005073
159MP0004264_abnormal_extraembryonic_tissu0.73441735
160MP0003638_abnormal_response/metabolism_0.70162188
161MP0001915_intracranial_hemorrhage0.67028173
162MP0001545_abnormal_hematopoietic_system0.66202418
163MP0005397_hematopoietic_system_phenotyp0.66202418
164MP0002736_abnormal_nociception_after0.65456866

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.84923730
2Elevated erythrocyte sedimentation rate (HP:0003565)4.98341352
3Eczematoid dermatitis (HP:0000976)4.64989949
4Orchitis (HP:0100796)4.54899259
5Myositis (HP:0100614)4.46443927
6Recurrent abscess formation (HP:0002722)4.18695924
7Stomatitis (HP:0010280)4.14664573
8Retrobulbar optic neuritis (HP:0100654)4.10990007
9Optic neuritis (HP:0100653)4.10990007
10Prolonged bleeding time (HP:0003010)3.98922787
11Abnormality of macrophages (HP:0004311)3.98252885
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.95768369
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.95768369
14Chronic otitis media (HP:0000389)3.95117693
15Abnormal platelet volume (HP:0011876)3.94973569
16Recurrent bacterial skin infections (HP:0005406)3.88861323
17Hypochromic anemia (HP:0001931)3.64695666
18Encephalitis (HP:0002383)3.40206011
19Recurrent gram-negative bacterial infections (HP:0005420)3.25606033
20Anomalous pulmonary venous return (HP:0010772)3.23944531
21Increased mean platelet volume (HP:0011877)3.14287186
22Spontaneous hematomas (HP:0007420)3.11779503
23Abnormality of the pulmonary veins (HP:0011718)3.11650162
24Microcytic anemia (HP:0001935)3.09239601
25Abnormal lung lobation (HP:0002101)3.01431314
26Menorrhagia (HP:0000132)2.96123515
27Metaphyseal cupping (HP:0003021)2.86263071
28Keratoconjunctivitis sicca (HP:0001097)2.82614553
29Rib fusion (HP:0000902)2.81978672
30Septo-optic dysplasia (HP:0100842)2.79648972
31Gastrointestinal infarctions (HP:0005244)2.79019869
32Abnormality of the corticospinal tract (HP:0002492)2.78472133
33Chronic obstructive pulmonary disease (HP:0006510)2.77579571
34Obstructive lung disease (HP:0006536)2.77579571
35Bifid tongue (HP:0010297)2.75860650
36Episodic fever (HP:0001954)2.75645728
37Increased IgM level (HP:0003496)2.74731338
38Hypoplastic left heart (HP:0004383)2.73685986
39Hypoplastic pelvis (HP:0008839)2.73575353
40Subacute progressive viral hepatitis (HP:0006572)2.73551474
41Short 4th metacarpal (HP:0010044)2.72827388
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.72827388
43Esophageal atresia (HP:0002032)2.70705800
44Aplasia/Hypoplasia of the patella (HP:0006498)2.69574869
45Keratoconjunctivitis (HP:0001096)2.65236440
46Urticaria (HP:0001025)2.64018270
47Midline defect of the nose (HP:0004122)2.60080325
48Anorexia (HP:0002039)2.55576566
49Nasal polyposis (HP:0100582)2.53517419
50Anophthalmia (HP:0000528)2.52735603
51Gingival bleeding (HP:0000225)2.51966332
52Meningitis (HP:0001287)2.50315709
53Nephroblastoma (Wilms tumor) (HP:0002667)2.50150449
54Aqueductal stenosis (HP:0002410)2.47506825
55Abnormal vertebral ossification (HP:0100569)2.47119951
56Epistaxis (HP:0000421)2.46509056
57Gingivitis (HP:0000230)2.43601103
58Petechiae (HP:0000967)2.43127238
59Chest pain (HP:0100749)2.35546058
60Breast aplasia (HP:0100783)2.34977595
61Myelomeningocele (HP:0002475)2.33347737
62Ectopic kidney (HP:0000086)2.32404142
63Embryonal renal neoplasm (HP:0011794)2.30805927
64Chronic sinusitis (HP:0011109)2.30376910
65Supernumerary spleens (HP:0009799)2.27311174
66Recurrent skin infections (HP:0001581)2.26166189
67Osteomalacia (HP:0002749)2.25378548
68Abnormality of the phalanges of the hallux (HP:0010057)2.24869881
69Absent septum pellucidum (HP:0001331)2.24803264
70Recurrent fungal infections (HP:0002841)2.24561361
71Intestinal atresia (HP:0011100)2.22887685
72Abnormality of the fingertips (HP:0001211)2.22215968
73Shawl scrotum (HP:0000049)2.20321719
74Patellar aplasia (HP:0006443)2.20263106
75Renal hypoplasia (HP:0000089)2.18870328
76Arterial thrombosis (HP:0004420)2.18836137
77Aplasia/Hypoplasia of the breasts (HP:0010311)2.18496930
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.17794423
79Decreased lacrimation (HP:0000633)2.16941230
80Colon cancer (HP:0003003)2.16399771
81Increased IgE level (HP:0003212)2.15680469
82Abnormal auditory evoked potentials (HP:0006958)2.15350070
83Abnormality of the parathyroid morphology (HP:0011766)2.15187981
84Abnormality of the distal phalanx of the thumb (HP:0009617)2.14958933
85Abnormality of the septum pellucidum (HP:0007375)2.13163670
86Skull defect (HP:0001362)2.12308078
87Alacrima (HP:0000522)2.11876721
88Neoplasm of the adrenal cortex (HP:0100641)2.10067404
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09557368
90Adrenal hypoplasia (HP:0000835)2.09459531
91Peritonitis (HP:0002586)2.08872598
92Erectile abnormalities (HP:0100639)2.08851632
93Gastrointestinal atresia (HP:0002589)2.08242842
94Hemivertebrae (HP:0002937)2.07467275
95Double outlet right ventricle (HP:0001719)2.07393221
96Congenital malformation of the right heart (HP:0011723)2.07393221
97Agnosia (HP:0010524)2.06911823
98Cerebral hypomyelination (HP:0006808)2.05420086
99Hypoplastic heart (HP:0001961)2.03968518
100Pseudobulbar signs (HP:0002200)2.03035468
101Hypogonadotrophic hypogonadism (HP:0000044)2.02992150
102Medulloblastoma (HP:0002885)2.02571152
103Rectal fistula (HP:0100590)2.02511602
104Rectovaginal fistula (HP:0000143)2.02511602
105Renal duplication (HP:0000075)2.00766385
106T lymphocytopenia (HP:0005403)1.99770706
107Abnormal hemoglobin (HP:0011902)1.99710211
108Mediastinal lymphadenopathy (HP:0100721)1.99452258
109Meningocele (HP:0002435)1.99297668
110Abnormal delayed hypersensitivity skin test (HP:0002963)1.98617887
111Morphological abnormality of the inner ear (HP:0011390)1.98520418
112Abnormality of the parietal bone (HP:0002696)1.96194404
113Partial duplication of the phalanx of hand (HP:0009999)1.95876675
114Abnormality of the fetal cardiovascular system (HP:0010948)1.93765568
115Abnormal umbilical cord blood vessels (HP:0011403)1.93765568
116Single umbilical artery (HP:0001195)1.93765568
117Abnormality of the 4th metacarpal (HP:0010012)1.93485838
118Bilateral microphthalmos (HP:0007633)1.93018897
119Vertebral clefting (HP:0008428)1.92584987
120Diastasis recti (HP:0001540)1.92069387
121Toxemia of pregnancy (HP:0100603)1.91650130
122Abnormality of the labia minora (HP:0012880)1.91437777
123Aplasia involving forearm bones (HP:0009822)1.90730770
124Absent forearm bone (HP:0003953)1.90730770
125Absent radius (HP:0003974)1.90373047
126Amaurosis fugax (HP:0100576)1.90076059
127Abnormal number of incisors (HP:0011064)1.89568333
128Recurrent cutaneous fungal infections (HP:0011370)1.89062424
129Chronic mucocutaneous candidiasis (HP:0002728)1.89062424
130Horseshoe kidney (HP:0000085)1.88393469
131Premature loss of primary teeth (HP:0006323)1.88299657
132Partial duplication of thumb phalanx (HP:0009944)1.87882787
133Oligodactyly (hands) (HP:0001180)1.87573818
134Reticulocytopenia (HP:0001896)1.86945055
135Bicornuate uterus (HP:0000813)1.86587422
136Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.85698434
137Short phalanx of the thumb (HP:0009660)1.85232481
138Choroideremia (HP:0001139)1.84506460
139Atresia of the external auditory canal (HP:0000413)1.83752606
140Cupped ear (HP:0000378)1.83400626
141Malignant gastrointestinal tract tumors (HP:0006749)1.81693907
142Gastrointestinal carcinoma (HP:0002672)1.81693907
143Large earlobe (HP:0009748)1.80732309
144Intestinal fistula (HP:0100819)1.80479202
145Abnormality of the aortic arch (HP:0012303)1.79268052
146Growth hormone deficiency (HP:0000824)1.78135142
147Abnormality of the nasal mucosa (HP:0000433)1.77987502
148Breast hypoplasia (HP:0003187)1.76575276
149Abnormality of the lacrimal duct (HP:0011481)1.76056939
150Abnormality of the nasolacrimal system (HP:0000614)1.75172893
151Abnormality of T cell number (HP:0011839)1.74024783
152Abnormality of glycolysis (HP:0004366)1.72909919
153Increased serum pyruvate (HP:0003542)1.72909919
154Hepatoblastoma (HP:0002884)1.72490732
155Abnormality of the 1st metacarpal (HP:0010009)1.72449242
156Prominent occiput (HP:0000269)1.71690657
157Sepsis (HP:0100806)1.71182712
158Neonatal hypoglycemia (HP:0001998)1.70057423
159Difficulty running (HP:0009046)1.69482356
160Supernumerary ribs (HP:0005815)1.69415544
161Transitional cell carcinoma of the bladder (HP:0006740)1.69069358
162Upper motor neuron abnormality (HP:0002127)1.68776990
163Cutaneous finger syndactyly (HP:0010554)1.68709028
164Pancreatic islet-cell hyperplasia (HP:0004510)1.67105937
165Pulmonary embolism (HP:0002204)1.67086485
166Preauricular pit (HP:0004467)1.66914528
167Periauricular skin pits (HP:0100277)1.66914528
168Supernumerary bones of the axial skeleton (HP:0009144)1.66745087
169Cellulitis (HP:0100658)1.66488755
170Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66351703
171Absent eyebrow (HP:0002223)1.65935473
172Tracheoesophageal fistula (HP:0002575)1.65471384
173Leukocytosis (HP:0001974)1.65351378
174Abnormal hair whorl (HP:0010721)1.64897680
175Abnormality of the intervertebral disk (HP:0005108)1.64007283
176Stenosis of the external auditory canal (HP:0000402)1.63427925
177Duplication of thumb phalanx (HP:0009942)1.63170654
178Coarctation of aorta (HP:0001680)1.62985130
179Ectopic anus (HP:0004397)1.62889127
180Respiratory difficulties (HP:0002880)1.62796470
181Aplasia/Hypoplasia of the sternum (HP:0006714)1.62488357
182Abnormal pancreas size (HP:0012094)1.62022784
183Coronal craniosynostosis (HP:0004440)1.61269081
184Cellular immunodeficiency (HP:0005374)1.61072525
185Oligodactyly (HP:0012165)1.60668134
186Muscle fiber atrophy (HP:0100295)1.59985639
187Broad distal phalanx of finger (HP:0009836)1.59659286
188Absent eyelashes (HP:0000561)1.59484243
189Preaxial foot polydactyly (HP:0001841)1.59352437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.65731255
2STK393.26603443
3MKNK13.11849497
4MAP2K32.72289900
5RIPK42.72221435
6CSK2.71021666
7ICK2.41296904
8BUB12.40297036
9EPHB22.25612499
10TAF12.22547984
11OXSR12.15920765
12TAOK12.15514986
13CDK192.14109902
14CLK12.11443990
15BCR2.10401042
16SIK32.08220504
17STK102.06789629
18MKNK22.00129135
19GRK61.95336291
20MAP3K111.93950213
21SRPK11.88655384
22WEE11.84670446
23FES1.82889043
24CDC71.81822239
25HCK1.78688189
26TGFBR21.77983395
27NEK21.77826336
28PTK61.77790628
29CDK121.76829830
30MAP4K11.75903250
31MET1.73452067
32SMG11.72770864
33UHMK11.62975506
34TIE11.62258130
35KDR1.58014220
36PLK41.55849179
37PTK2B1.55289837
38TNIK1.52555297
39TNK21.49453826
40CDK71.46255720
41BTK1.44787161
42STK161.42727944
43OBSCN1.41880469
44LIMK11.40661945
45LATS11.39617908
46TLK11.38525746
47LATS21.37931311
48PLK31.37419079
49MAP3K31.35963013
50STK38L1.33778030
51WNK41.32699799
52BRD41.31698263
53CSNK1G31.31475991
54LRRK21.30796712
55ZAP701.29827298
56GRK51.27511435
57TSSK61.27479617
58CSNK1A1L1.26456753
59TGFBR11.26197681
60IRAK21.23929405
61BMX1.23408637
62IRAK11.22987971
63NEK61.22405448
64BLK1.20998261
65DYRK21.19510774
66CHEK21.18479172
67MATK1.16216879
68ERN11.16106451
69AURKA1.15953778
70MAPK131.15047855
71VRK21.14985207
72TESK21.14817856
73TYRO31.14787901
74TTK1.13336748
75CDK81.11442373
76PRKD21.11286320
77PLK11.10542182
78MAP2K41.10200272
79CSNK1G11.09568174
80BRSK21.09551027
81MARK31.08224005
82PRPF4B1.05142805
83PTK21.04185097
84NUAK11.03648802
85PBK1.00490909
86MARK20.99903180
87STK110.99020007
88RAF10.97656872
89PASK0.97350060
90MAP3K60.96256188
91MAP3K80.96107776
92TRIM280.95465882
93PKN10.94815551
94BRSK10.94570326
95EIF2AK20.93945858
96WNK30.93090415
97CHEK10.91845560
98ALK0.91150421
99MAP3K20.88306207
100VRK10.87794308
101KSR20.87686244
102TXK0.87434608
103EPHA20.86243066
104JAK20.86219718
105PAK40.86004784
106LYN0.82913628
107RPS6KB20.82461740
108CDK140.81834759
109GRK70.81424930
110PNCK0.80797297
111ROCK20.80583048
112MOS0.79796135
113MELK0.78114869
114MAP3K10.77652894
115PRKG20.77507449
116ERBB30.77357717
117WNK10.76828403
118LCK0.76155726
119AURKB0.73788995
120MAP3K100.73535389
121DYRK30.70192516
122PIK3CA0.68697187
123CDK150.68581111
124CDK10.68323985
125CDK180.68160775
126TYK20.67058828
127CDK11A0.66592261
128MAPKAPK20.64791573
129BMPR1B0.64089521
130KSR10.62645465
131PAK10.61094191
132EPHB10.60961068
133FGR0.60838069
134PRKCZ0.59954367
135DMPK0.59639809
136CDK20.59085269
137NTRK20.57413070
138ZAK0.56315123
139CDK90.55646320
140ILK0.55256060
141CSNK1G20.55008534
142CSF1R0.53939868
143DYRK1A0.53629469
144PRKD30.53283235
145YES10.53101541
146ATM0.53001438
147NME20.52991190
148DYRK1B0.52334130
149FGFR20.50334319
150SYK0.48745818
151NME10.48049769
152FYN0.48018107
153ADRBK10.46098193
154RPS6KA10.45644638
155MAP3K50.45102867
156CSNK1D0.44780677
157CAMK2D0.44584504
158ERBB40.44215265
159TEC0.44173134
160STK30.43684860
161CSNK1E0.42894437
162FGFR10.42266837
163ERBB20.42204626
164PRKCD0.41726997
165ROCK10.40569624
166ITK0.40326127
167JAK30.39954460
168PRKACB0.37912061
169STK380.36261714
170PAK20.36144325
171ATR0.36039450

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.88701456
2Spliceosome_Homo sapiens_hsa030402.98927498
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.70610276
4Homologous recombination_Homo sapiens_hsa034402.66388384
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58227709
6Basal cell carcinoma_Homo sapiens_hsa052172.57356178
7RNA polymerase_Homo sapiens_hsa030202.56110263
8Ribosome_Homo sapiens_hsa030102.54078552
9Cell cycle_Homo sapiens_hsa041102.53536361
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.49710355
11DNA replication_Homo sapiens_hsa030302.45108370
12Basal transcription factors_Homo sapiens_hsa030222.37382087
13Osteoclast differentiation_Homo sapiens_hsa043802.31177363
14Mismatch repair_Homo sapiens_hsa034302.31006316
15Hedgehog signaling pathway_Homo sapiens_hsa043402.20510224
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16259645
17mRNA surveillance pathway_Homo sapiens_hsa030152.14470575
18RNA transport_Homo sapiens_hsa030132.01043811
19Hippo signaling pathway_Homo sapiens_hsa043902.00951242
20Chemokine signaling pathway_Homo sapiens_hsa040621.96589478
21Steroid biosynthesis_Homo sapiens_hsa001001.91422285
22Fatty acid elongation_Homo sapiens_hsa000621.89080494
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.87843737
24Leishmaniasis_Homo sapiens_hsa051401.86887542
25Malaria_Homo sapiens_hsa051441.83897353
26Base excision repair_Homo sapiens_hsa034101.82859089
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81041600
28Nucleotide excision repair_Homo sapiens_hsa034201.78340197
29Non-homologous end-joining_Homo sapiens_hsa034501.76965250
30Platelet activation_Homo sapiens_hsa046111.76515915
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73358213
32Notch signaling pathway_Homo sapiens_hsa043301.71914312
33Shigellosis_Homo sapiens_hsa051311.70393800
34Primary immunodeficiency_Homo sapiens_hsa053401.65593928
35Oocyte meiosis_Homo sapiens_hsa041141.64028007
36Axon guidance_Homo sapiens_hsa043601.58563954
37Tight junction_Homo sapiens_hsa045301.58485603
38Acute myeloid leukemia_Homo sapiens_hsa052211.56335307
39Cardiac muscle contraction_Homo sapiens_hsa042601.54592717
40RNA degradation_Homo sapiens_hsa030181.54083964
41Huntingtons disease_Homo sapiens_hsa050161.51428136
42Measles_Homo sapiens_hsa051621.49964142
43Fanconi anemia pathway_Homo sapiens_hsa034601.49873698
44Parkinsons disease_Homo sapiens_hsa050121.44634060
45B cell receptor signaling pathway_Homo sapiens_hsa046621.44271291
46Legionellosis_Homo sapiens_hsa051341.41469838
47African trypanosomiasis_Homo sapiens_hsa051431.40746003
48TGF-beta signaling pathway_Homo sapiens_hsa043501.37771752
49Oxidative phosphorylation_Homo sapiens_hsa001901.35792940
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34895129
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33454012
52Tuberculosis_Homo sapiens_hsa051521.32743591
53Proteasome_Homo sapiens_hsa030501.29896569
54Wnt signaling pathway_Homo sapiens_hsa043101.28377218
55Ether lipid metabolism_Homo sapiens_hsa005651.24635487
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21590428
57Hematopoietic cell lineage_Homo sapiens_hsa046401.19347700
58Non-small cell lung cancer_Homo sapiens_hsa052231.19185072
59Salmonella infection_Homo sapiens_hsa051321.17225154
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15946244
61Pancreatic cancer_Homo sapiens_hsa052121.15227406
62Endocytosis_Homo sapiens_hsa041441.11968439
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11078505
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10989454
65T cell receptor signaling pathway_Homo sapiens_hsa046601.10348308
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10029090
67Pyrimidine metabolism_Homo sapiens_hsa002401.09657732
68Chronic myeloid leukemia_Homo sapiens_hsa052201.09462082
69MicroRNAs in cancer_Homo sapiens_hsa052061.07892076
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07393144
71Renal cell carcinoma_Homo sapiens_hsa052111.07218429
72Herpes simplex infection_Homo sapiens_hsa051681.06834822
73Staphylococcus aureus infection_Homo sapiens_hsa051501.06666450
74Apoptosis_Homo sapiens_hsa042101.05328004
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02092085
76Sulfur relay system_Homo sapiens_hsa041221.01131896
77VEGF signaling pathway_Homo sapiens_hsa043701.00079241
78Phagosome_Homo sapiens_hsa041450.99937839
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98737276
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.95307334
81Adherens junction_Homo sapiens_hsa045200.95165750
82Regulation of autophagy_Homo sapiens_hsa041400.94545557
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92770768
84Alzheimers disease_Homo sapiens_hsa050100.92423936
85Hepatitis B_Homo sapiens_hsa051610.90060546
86Antigen processing and presentation_Homo sapiens_hsa046120.88149225
87Melanogenesis_Homo sapiens_hsa049160.87227410
88Hepatitis C_Homo sapiens_hsa051600.86444309
89Purine metabolism_Homo sapiens_hsa002300.84240875
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81196174
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79850825
92Inositol phosphate metabolism_Homo sapiens_hsa005620.75423119
93Viral carcinogenesis_Homo sapiens_hsa052030.75092348
94Pathways in cancer_Homo sapiens_hsa052000.73594380
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71422853
96Thyroid cancer_Homo sapiens_hsa052160.70931792
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.70070107
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67709452
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.67154441
100Viral myocarditis_Homo sapiens_hsa054160.66167128
101Influenza A_Homo sapiens_hsa051640.63689316
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63419326
103FoxO signaling pathway_Homo sapiens_hsa040680.62773858
104One carbon pool by folate_Homo sapiens_hsa006700.62309446
105Dilated cardiomyopathy_Homo sapiens_hsa054140.60426000
106Long-term depression_Homo sapiens_hsa047300.59557381
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.58522947
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57223983
109Sphingolipid metabolism_Homo sapiens_hsa006000.54390580
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53531222
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52324906
112Alcoholism_Homo sapiens_hsa050340.52267527
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51798006
114Proteoglycans in cancer_Homo sapiens_hsa052050.50643291
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50355694
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50157736
117Linoleic acid metabolism_Homo sapiens_hsa005910.50133486
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50033359
119HTLV-I infection_Homo sapiens_hsa051660.48382267
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47889032
121Arginine and proline metabolism_Homo sapiens_hsa003300.47883564
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47660144
123Toxoplasmosis_Homo sapiens_hsa051450.46613752
124Protein export_Homo sapiens_hsa030600.45689307
125Epstein-Barr virus infection_Homo sapiens_hsa051690.45516066
126Rap1 signaling pathway_Homo sapiens_hsa040150.45498003
127Ras signaling pathway_Homo sapiens_hsa040140.45386394
128Phototransduction_Homo sapiens_hsa047440.44856498
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44028234
130Melanoma_Homo sapiens_hsa052180.43527267
131Small cell lung cancer_Homo sapiens_hsa052220.42303152
132Pentose phosphate pathway_Homo sapiens_hsa000300.40621232
133ErbB signaling pathway_Homo sapiens_hsa040120.40079215
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.39860905
135MAPK signaling pathway_Homo sapiens_hsa040100.39642975
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39584680
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.39536749
138ECM-receptor interaction_Homo sapiens_hsa045120.39011049
139Colorectal cancer_Homo sapiens_hsa052100.38573967
140Lysine degradation_Homo sapiens_hsa003100.38295251
141p53 signaling pathway_Homo sapiens_hsa041150.38143072
142Focal adhesion_Homo sapiens_hsa045100.37849875
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.37737055
144Serotonergic synapse_Homo sapiens_hsa047260.37691276
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37487251
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37285537
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.36307851
148Systemic lupus erythematosus_Homo sapiens_hsa053220.35892271
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35702738
150Prostate cancer_Homo sapiens_hsa052150.33850084
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33610617
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32538043
153Biosynthesis of amino acids_Homo sapiens_hsa012300.31356004
154Gap junction_Homo sapiens_hsa045400.31177064
155HIF-1 signaling pathway_Homo sapiens_hsa040660.29205660
156Choline metabolism in cancer_Homo sapiens_hsa052310.28963043
157Arachidonic acid metabolism_Homo sapiens_hsa005900.28739068
158Butanoate metabolism_Homo sapiens_hsa006500.28733850
159Sulfur metabolism_Homo sapiens_hsa009200.27851798
160Endometrial cancer_Homo sapiens_hsa052130.24959368

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »