ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.61181327
2	respiratory chain complex IV assembly (GO:0008535)	4.22569923
3	cytochrome complex assembly (GO:0017004)	4.12167058
4	melanin biosynthetic process (GO:0042438)	4.09398976
5	platelet dense granule organization (GO:0060155)	4.04537519
6	secondary metabolite biosynthetic process (GO:0044550)	4.03716181
7	replication fork processing (GO:0031297)	4.00398226
8	cullin deneddylation (GO:0010388)	3.78733839
9	ketone body metabolic process (GO:1902224)	3.76549160
10	proteasome assembly (GO:0043248)	3.70900700
11	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.59349513
12	mitotic sister chromatid cohesion (GO:0007064)	3.51791103
13	anterograde synaptic vesicle transport (GO:0048490)	3.49263128
14	protein deneddylation (GO:0000338)	3.48793569
15	coenzyme catabolic process (GO:0009109)	3.46986550
16	melanin metabolic process (GO:0006582)	3.46356341
17	developmental pigmentation (GO:0048066)	3.46209823
18	melanosome organization (GO:0032438)	3.45266196
19	dopamine transport (GO:0015872)	3.42297981
20	histone H2A acetylation (GO:0043968)	3.40617025
21	lactate metabolic process (GO:0006089)	3.37684598
22	response to pheromone (GO:0019236)	3.31844223
23	positive regulation of amino acid transport (GO:0051957)	3.29594773
24	protein K11-linked deubiquitination (GO:0035871)	3.29585695
25	positive regulation of glycolytic process (GO:0045821)	3.26398515
26	keratinocyte development (GO:0003334)	3.25442035
27	endosome to pigment granule transport (GO:0043485)	3.24284951
28	endosome to melanosome transport (GO:0035646)	3.24284951
29	protein prenylation (GO:0018342)	3.22727391
30	prenylation (GO:0097354)	3.22727391
31	kinetochore assembly (GO:0051382)	3.22700612
32	protein K6-linked ubiquitination (GO:0085020)	3.21308802
33	regulation of centriole replication (GO:0046599)	3.14904159
34	pigment granule organization (GO:0048753)	3.13794431
35	epithelial cilium movement (GO:0003351)	3.13659973
36	CENP-A containing nucleosome assembly (GO:0034080)	3.12552823
37	cellular ketone body metabolic process (GO:0046950)	3.10538937
38	proline transport (GO:0015824)	3.05428263
39	histone exchange (GO:0043486)	3.04077776
40	chromatin remodeling at centromere (GO:0031055)	3.04020731
41	response to redox state (GO:0051775)	3.02741600
42	protein complex biogenesis (GO:0070271)	3.02677828
43	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.01372892
44	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.00149275
45	intraciliary transport (GO:0042073)	2.99265657
46	positive regulation of protein autophosphorylation (GO:0031954)	2.98794721
47	attachment of spindle microtubules to kinetochore (GO:0008608)	2.98598408
48	inositol phosphate catabolic process (GO:0071545)	2.95836219
49	double-strand break repair via homologous recombination (GO:0000724)	2.92949567
50	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.90602793
51	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.90602793
52	regulation of translation, ncRNA-mediated (GO:0045974)	2.90602793
53	mitotic G2/M transition checkpoint (GO:0044818)	2.88585590
54	recombinational repair (GO:0000725)	2.87236066
55	regulation of DNA endoreduplication (GO:0032875)	2.84762097
56	kinetochore organization (GO:0051383)	2.82690721
57	olfactory bulb development (GO:0021772)	2.81602652
58	mitotic G2 DNA damage checkpoint (GO:0007095)	2.81284317
59	branched-chain amino acid catabolic process (GO:0009083)	2.79476087
60	female gonad development (GO:0008585)	2.71523286
61	cellular response to oxygen radical (GO:0071450)	2.71035142
62	removal of superoxide radicals (GO:0019430)	2.71035142
63	cellular response to superoxide (GO:0071451)	2.71035142
64	cornea development in camera-type eye (GO:0061303)	2.69008059
65	pigmentation (GO:0043473)	2.67248194
66	negative regulation of execution phase of apoptosis (GO:1900118)	2.64822129
67	negative regulation of neurological system process (GO:0031645)	2.64678468
68	regulation of Rac protein signal transduction (GO:0035020)	2.64059987
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.62864086
70	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.62697118
71	reciprocal DNA recombination (GO:0035825)	2.61498252
72	reciprocal meiotic recombination (GO:0007131)	2.61498252
73	protein polyglutamylation (GO:0018095)	2.60964844
74	DNA strand renaturation (GO:0000733)	2.60583364
75	cilium assembly (GO:0042384)	2.58982797
76	DNA catabolic process, exonucleolytic (GO:0000738)	2.58471508
77	heme transport (GO:0015886)	2.58366510
78	cilium organization (GO:0044782)	2.56957633
79	pyrimidine nucleobase catabolic process (GO:0006208)	2.56268916
80	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.53052221
81	cilium movement (GO:0003341)	2.52932681
82	negative regulation of neurotransmitter transport (GO:0051589)	2.50084887
83	aldehyde catabolic process (GO:0046185)	2.49340024
84	photoreceptor cell maintenance (GO:0045494)	2.48578429
85	inositol phosphate dephosphorylation (GO:0046855)	2.47093559
86	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.47093559
87	DNA replication-dependent nucleosome organization (GO:0034723)	2.46471624
88	DNA replication-dependent nucleosome assembly (GO:0006335)	2.46471624
89	S-adenosylmethionine metabolic process (GO:0046500)	2.43555701
90	polyol catabolic process (GO:0046174)	2.42819227
91	glycosphingolipid biosynthetic process (GO:0006688)	2.42582636
92	ribosome assembly (GO:0042255)	2.42314710
93	synapsis (GO:0007129)	2.42268139
94	regulation of meiosis I (GO:0060631)	2.42003352
95	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.39135303
96	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.38978058
97	melanosome transport (GO:0032402)	2.38175980
98	retinal ganglion cell axon guidance (GO:0031290)	2.38116000
99	positive regulation of glycoprotein metabolic process (GO:1903020)	2.37542240
100	single strand break repair (GO:0000012)	2.37278616

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.09461119
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.91995017
3	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.85511439
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.80881553
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79420127
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67567027
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.63426505
8	FUS_26573619_Chip-Seq_HEK293_Human	2.50802032
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.43538464
10	EWS_26573619_Chip-Seq_HEK293_Human	2.40304041
11	VDR_22108803_ChIP-Seq_LS180_Human	2.35655978
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27296001
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.23220615
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.13399858
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11749067
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09261306
17	P300_19829295_ChIP-Seq_ESCs_Human	2.06079209
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.05700584
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.02185419
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98302222
21	E2F7_22180533_ChIP-Seq_HELA_Human	1.95491384
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93492813
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.83807964
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79663799
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79632719
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74784490
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73877428
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.70761344
29	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.69001361
30	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66142076
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.65070398
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64101309
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.61285060
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58941770
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57357819
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55040933
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.54083434
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53930627
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.53630849
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53630849
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53027354
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47645212
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45463345
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45136189
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42905121
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.41565454
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40639695
48	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.39922459
49	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.39043388
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38645000
51	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.37309001
52	AR_25329375_ChIP-Seq_VCAP_Human	1.36021812
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35733993
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35401229
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34155324
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32362247
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.32013398
58	TCF4_23295773_ChIP-Seq_U87_Human	1.30852787
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30812742
60	STAT3_23295773_ChIP-Seq_U87_Human	1.27869454
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27780015
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.27415850
63	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.26907859
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.26680289
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25716885
66	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.25532449
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23924727
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23924727
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23426426
70	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.22875561
71	VDR_23849224_ChIP-Seq_CD4+_Human	1.20376007
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.19434237
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16619286
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16577685
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13862664
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12816719
77	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.11870351
78	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11690574
79	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.11058271
80	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.10542216
81	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.10542216
82	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.08455560
83	MYC_18940864_ChIP-ChIP_HL60_Human	1.08342217
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08213020
85	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08015241
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06712628
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06184491
88	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.05646735
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04442856
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03011239
91	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.02931715
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02474734
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01038980
94	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.00673032
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.99175768
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98951920
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98698522
98	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98567939
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97434899
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97034259

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	5.30143637
2	MP0005171_absent_coat_pigmentation	5.19887856
3	MP0000569_abnormal_digit_pigmentation	4.49540884
4	MP0000015_abnormal_ear_pigmentation	3.86903121
5	MP0005408_hypopigmentation	3.68612570
6	MP0003136_yellow_coat_color	3.56513666
7	MP0005174_abnormal_tail_pigmentation	3.36382063
8	MP0005075_abnormal_melanosome_morpholog	3.27725579
9	MP0002938_white_spotting	2.87713440
10	MP0002102_abnormal_ear_morphology	2.82952589
11	MP0005248_abnormal_Harderian_gland	2.58783817
12	MP0003195_calcinosis	2.37429654
13	MP0002095_abnormal_skin_pigmentation	2.25729322
14	MP0000427_abnormal_hair_cycle	2.15095346
15	MP0010094_abnormal_chromosome_stability	2.14674760
16	MP0002837_dystrophic_cardiac_calcinosis	1.99611071
17	MP0002254_reproductive_system_inflammat	1.89868985
18	MP0005253_abnormal_eye_physiology	1.89852934
19	MP0003890_abnormal_embryonic-extraembry	1.86475855
20	MP0000371_diluted_coat_color	1.80286025
21	MP0001324_abnormal_eye_pigmentation	1.78903087
22	MP0006054_spinal_hemorrhage	1.77508425
23	MP0002090_abnormal_vision	1.76182840
24	MP0004381_abnormal_hair_follicle	1.74147844
25	MP0003718_maternal_effect	1.69075513
26	MP0008058_abnormal_DNA_repair	1.63932627
27	MP0003011_delayed_dark_adaptation	1.59245606
28	MP0005551_abnormal_eye_electrophysiolog	1.55897271
29	MP0006072_abnormal_retinal_apoptosis	1.50247087
30	MP0003787_abnormal_imprinting	1.48405782
31	MP0009697_abnormal_copulation	1.47896739
32	MP0008877_abnormal_DNA_methylation	1.42945891
33	MP0001293_anophthalmia	1.40906493
34	MP0002638_abnormal_pupillary_reflex	1.39022633
35	MP0001485_abnormal_pinna_reflex	1.34809485
36	MP0003186_abnormal_redox_activity	1.30685271
37	MP0004133_heterotaxia	1.22858598
38	MP0004147_increased_porphyrin_level	1.15003506
39	MP0002736_abnormal_nociception_after	1.11800761
40	MP0008057_abnormal_DNA_replication	1.11077988
41	MP0008775_abnormal_heart_ventricle	1.10046189
42	MP0003880_abnormal_central_pattern	1.09569311
43	MP0002233_abnormal_nose_morphology	1.08709197
44	MP0002909_abnormal_adrenal_gland	1.08598919
45	MP0003806_abnormal_nucleotide_metabolis	1.07619390
46	MP0005646_abnormal_pituitary_gland	1.00211698
47	MP0003937_abnormal_limbs/digits/tail_de	0.99828544
48	MP0006292_abnormal_olfactory_placode	0.99146837
49	MP0004043_abnormal_pH_regulation	0.98018365
50	MP0000516_abnormal_urinary_system	0.97412665
51	MP0005367_renal/urinary_system_phenotyp	0.97412665
52	MP0010386_abnormal_urinary_bladder	0.96399898
53	MP0001764_abnormal_homeostasis	0.95874818
54	MP0000631_abnormal_neuroendocrine_gland	0.93809874
55	MP0006036_abnormal_mitochondrial_physio	0.92882812
56	MP0002751_abnormal_autonomic_nervous	0.92561447
57	MP0002177_abnormal_outer_ear	0.91735373
58	MP0005391_vision/eye_phenotype	0.90569649
59	MP0002075_abnormal_coat/hair_pigmentati	0.88608332
60	MP0009046_muscle_twitch	0.86313290
61	MP0001529_abnormal_vocalization	0.85446922
62	MP0005395_other_phenotype	0.84805866
63	MP0000647_abnormal_sebaceous_gland	0.82787188
64	MP0003943_abnormal_hepatobiliary_system	0.81868291
65	MP0003252_abnormal_bile_duct	0.80820174
66	MP0003786_premature_aging	0.80050634
67	MP0001984_abnormal_olfaction	0.78880447
68	MP0009780_abnormal_chondrocyte_physiolo	0.77954226
69	MP0003122_maternal_imprinting	0.76298687
70	MP0001186_pigmentation_phenotype	0.74761229
71	MP0001968_abnormal_touch/_nociception	0.73133430
72	MP0004215_abnormal_myocardial_fiber	0.71434340
73	MP0003111_abnormal_nucleus_morphology	0.70939490
74	MP0008932_abnormal_embryonic_tissue	0.70694433
75	MP0005386_behavior/neurological_phenoty	0.69979280
76	MP0004924_abnormal_behavior	0.69979280
77	MP0003646_muscle_fatigue	0.69505096
78	MP0001986_abnormal_taste_sensitivity	0.68313523
79	MP0002163_abnormal_gland_morphology	0.66588231
80	MP0009745_abnormal_behavioral_response	0.65803192
81	MP0004484_altered_response_of	0.64474970
82	MP0008872_abnormal_physiological_respon	0.63610880
83	MP0003121_genomic_imprinting	0.63361890
84	MP0005197_abnormal_uvea_morphology	0.63239702
85	MP0002876_abnormal_thyroid_physiology	0.61995816
86	MP0005187_abnormal_penis_morphology	0.60255920
87	MP0003656_abnormal_erythrocyte_physiolo	0.60185669
88	MP0005084_abnormal_gallbladder_morpholo	0.60120004
89	MP0001929_abnormal_gametogenesis	0.57706250
90	MP0001119_abnormal_female_reproductive	0.56560168
91	MP0005220_abnormal_exocrine_pancreas	0.56131973
92	MP0001486_abnormal_startle_reflex	0.55286495
93	MP0010678_abnormal_skin_adnexa	0.54314566
94	MP0003077_abnormal_cell_cycle	0.52867118
95	MP0002822_catalepsy	0.52775006
96	MP0010234_abnormal_vibrissa_follicle	0.52685151
97	MP0003698_abnormal_male_reproductive	0.52668121
98	MP0002272_abnormal_nervous_system	0.52644224
99	MP0005195_abnormal_posterior_eye	0.52626239
100	MP0003755_abnormal_palate_morphology	0.51903153

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the fovea (HP:0007750)	4.64667245
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.64667245
3	Albinism (HP:0001022)	4.00889295
4	Abnormality of the fovea (HP:0000493)	3.95890128
5	Aplasia/Hypoplasia of the macula (HP:0008059)	3.85970576
6	Patchy hypopigmentation of hair (HP:0011365)	3.67134037
7	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.54369460
8	Pancreatic fibrosis (HP:0100732)	3.51164767
9	White forelock (HP:0002211)	3.46969074
10	Hyperinsulinemic hypoglycemia (HP:0000825)	3.24013686
11	Generalized hypopigmentation (HP:0007513)	2.96230880
12	Pancreatic cysts (HP:0001737)	2.95599381
13	Volvulus (HP:0002580)	2.92398660
14	Congenital sensorineural hearing impairment (HP:0008527)	2.87673449
15	Ketoacidosis (HP:0001993)	2.73446229
16	Ocular albinism (HP:0001107)	2.68394854
17	Intestinal atresia (HP:0011100)	2.65708770
18	Iris hypopigmentation (HP:0007730)	2.64983864
19	Hyperglycemia (HP:0003074)	2.62938501
20	Hypoglycemic seizures (HP:0002173)	2.61036585
21	Abnormality of the labia minora (HP:0012880)	2.59948765
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.47035856
23	True hermaphroditism (HP:0010459)	2.44934287
24	Gaze-evoked nystagmus (HP:0000640)	2.42461645
25	Abnormality of methionine metabolism (HP:0010901)	2.40529395
26	Methylmalonic acidemia (HP:0002912)	2.39549688
27	Abnormality of glycolysis (HP:0004366)	2.39158187
28	Median cleft lip (HP:0000161)	2.39068649
29	Congenital stationary night blindness (HP:0007642)	2.36390989
30	Short tibia (HP:0005736)	2.36227885
31	Medial flaring of the eyebrow (HP:0010747)	2.35542225
32	Pancreatic islet-cell hyperplasia (HP:0004510)	2.33875927
33	Molar tooth sign on MRI (HP:0002419)	2.33467080
34	Abnormality of midbrain morphology (HP:0002418)	2.33467080
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.32897404
36	Reduced antithrombin III activity (HP:0001976)	2.32605429
37	Nephronophthisis (HP:0000090)	2.28640396
38	Aqueductal stenosis (HP:0002410)	2.28557713
39	Abnormality of chromosome stability (HP:0003220)	2.28276465
40	Congenital hepatic fibrosis (HP:0002612)	2.27228876
41	Abnormality of macular pigmentation (HP:0008002)	2.26796094
42	Cutaneous melanoma (HP:0012056)	2.24375925
43	Neoplasm of the adrenal cortex (HP:0100641)	2.24287797
44	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.24082518
45	Adrenal hypoplasia (HP:0000835)	2.23309185
46	Neoplasm of the adrenal gland (HP:0100631)	2.22189531
47	Meckel diverticulum (HP:0002245)	2.20929396
48	Progressive inability to walk (HP:0002505)	2.19952902
49	Increased serum pyruvate (HP:0003542)	2.18098678
50	Gastrointestinal atresia (HP:0002589)	2.17518092
51	Abnormality of the renal medulla (HP:0100957)	2.16505676
52	Hypothermia (HP:0002045)	2.15471727
53	Abnormality of the ileum (HP:0001549)	2.15229533
54	Large for gestational age (HP:0001520)	2.13884666
55	Abnormality of the renal cortex (HP:0011035)	2.11149641
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08273995
57	Tubulointerstitial nephritis (HP:0001970)	2.07485770
58	Abnormality of the metopic suture (HP:0005556)	2.07040277
59	Chromsome breakage (HP:0040012)	2.05129361
60	Hypoglycemic coma (HP:0001325)	2.04781094
61	Genital tract atresia (HP:0001827)	2.03535159
62	Type I transferrin isoform profile (HP:0003642)	2.02128187
63	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.99425764
64	Ependymoma (HP:0002888)	1.97827725
65	Polydipsia (HP:0001959)	1.97688650
66	Abnormal drinking behavior (HP:0030082)	1.97688650
67	Insulin-resistant diabetes mellitus (HP:0000831)	1.96203543
68	Abnormal protein glycosylation (HP:0012346)	1.95548619
69	Abnormal glycosylation (HP:0012345)	1.95548619
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.95548619
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.95548619
72	Abnormality of vitamin B metabolism (HP:0004340)	1.95367313
73	Abnormality of the fetal cardiovascular system (HP:0010948)	1.95288589
74	Abnormal umbilical cord blood vessels (HP:0011403)	1.95288589
75	Single umbilical artery (HP:0001195)	1.95288589
76	Sloping forehead (HP:0000340)	1.93242299
77	Nephrogenic diabetes insipidus (HP:0009806)	1.92484216
78	Preaxial hand polydactyly (HP:0001177)	1.91618036
79	Abnormality of endocrine pancreas physiology (HP:0012093)	1.90880053
80	Abnormality of the pancreatic islet cells (HP:0006476)	1.90880053
81	Long clavicles (HP:0000890)	1.90119355
82	Abnormality of the preputium (HP:0100587)	1.89604968
83	Postaxial foot polydactyly (HP:0001830)	1.89550427
84	Progressive macrocephaly (HP:0004481)	1.87443234
85	Astigmatism (HP:0000483)	1.86923681
86	Bile duct proliferation (HP:0001408)	1.86128795
87	Abnormal biliary tract physiology (HP:0012439)	1.86128795
88	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.85360462
89	Hyperglycinemia (HP:0002154)	1.85326448
90	Tubular atrophy (HP:0000092)	1.84840575
91	Metaphyseal dysplasia (HP:0100255)	1.82253810
92	Bifid tongue (HP:0010297)	1.81005482
93	Acute necrotizing encephalopathy (HP:0006965)	1.80786549
94	Acute encephalopathy (HP:0006846)	1.79918755
95	Methylmalonic aciduria (HP:0012120)	1.79326983
96	Congenital primary aphakia (HP:0007707)	1.79259011
97	Postaxial hand polydactyly (HP:0001162)	1.78441547
98	Increased CSF lactate (HP:0002490)	1.78063421
99	Posterior subcapsular cataract (HP:0007787)	1.76860677
100	Severe visual impairment (HP:0001141)	1.76197855

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.87545295
2	WNK3	3.09605309
3	TRIM28	3.08086999
4	NEK1	2.73006950
5	BMPR1B	2.67651133
6	WEE1	2.59283721
7	ACVR1B	2.50489985
8	MKNK2	2.33132049
9	MKNK1	2.30181238
10	BRSK2	2.28657203
11	PAK3	2.28479682
12	EIF2AK3	2.27435928
13	TNIK	2.18753892
14	ERBB3	2.09931384
15	SIK3	2.09488094
16	PLK2	2.09391538
17	TSSK6	2.06421601
18	FER	2.06019734
19	PDK2	2.02421999
20	PLK3	1.81142582
21	EIF2AK1	1.80705816
22	PNCK	1.78937698
23	NUAK1	1.75330171
24	PBK	1.73473472
25	AKT3	1.66008481
26	BCR	1.64933287
27	CSNK1G1	1.62163200
28	VRK2	1.56502746
29	PLK4	1.50398206
30	CSNK1G2	1.47006823
31	CSNK1G3	1.44203757
32	MARK3	1.30780759
33	INSRR	1.21059553
34	CASK	1.16334356
35	FGFR2	1.05660073
36	MAP3K4	1.03364051
37	STK24	1.01462755
38	GRK1	1.00168414
39	ZAK	0.93598229
40	TTK	0.91445006
41	MST4	0.90541084
42	FGFR1	0.90429841
43	BUB1	0.89111244
44	DYRK2	0.85565561
45	PAK6	0.83471319
46	VRK1	0.82620772
47	YES1	0.81948768
48	MAP4K2	0.81185941
49	MAPK13	0.80945636
50	BRSK1	0.78590491
51	PRKCE	0.76797821
52	CAMKK2	0.75514736
53	STK39	0.74817859
54	EIF2AK2	0.74746229
55	STK3	0.73540336
56	BCKDK	0.73347797
57	ADRBK2	0.70414209
58	PIM2	0.70204390
59	BRD4	0.68651790
60	CSNK1A1L	0.66423836
61	PTK2B	0.64402866
62	ATR	0.62965290
63	ERBB4	0.62094164
64	PLK1	0.61375822
65	CDK3	0.60840711
66	PRKCI	0.60771496
67	NEK9	0.60206107
68	MINK1	0.59997528
69	MAP2K7	0.58451902
70	TAF1	0.57957318
71	NLK	0.57113677
72	GSK3A	0.56974839
73	TGFBR1	0.56697263
74	PRKCG	0.56565699
75	SRPK1	0.54525809
76	MAPKAPK5	0.54401673
77	DYRK3	0.50383103
78	ADRBK1	0.50301032
79	TNK2	0.49813343
80	CLK1	0.48874254
81	RPS6KA4	0.48681132
82	PRKD3	0.47505879
83	CSNK1D	0.47341630
84	STK38L	0.46821398
85	OXSR1	0.46606605
86	ATM	0.45990370
87	ROCK2	0.39574590
88	CDC7	0.39372921
89	CHEK2	0.38983641
90	NTRK3	0.35785911
91	MAP2K1	0.35332774
92	OBSCN	0.34630461
93	FLT3	0.33883570
94	STK10	0.31428069
95	PINK1	0.29432627
96	CAMK2A	0.28683268
97	PRKD1	0.28205101
98	PKN1	0.27535379
99	ROCK1	0.26645813
100	EGFR	0.26566835

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.49253587
2	Propanoate metabolism_Homo sapiens_hsa00640	3.07203189
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.05297793
4	Protein export_Homo sapiens_hsa03060	2.75135670
5	Butanoate metabolism_Homo sapiens_hsa00650	2.68656318
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.64850078
7	Homologous recombination_Homo sapiens_hsa03440	2.56891394
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.44649906
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.39291374
10	Basal transcription factors_Homo sapiens_hsa03022	2.37132066
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.30761570
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.13845773
13	Proteasome_Homo sapiens_hsa03050	2.13811477
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83264324
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74041002
16	Circadian rhythm_Homo sapiens_hsa04710	1.72614672
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.72420560
18	One carbon pool by folate_Homo sapiens_hsa00670	1.72320038
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.68703760
20	Mismatch repair_Homo sapiens_hsa03430	1.64153828
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.60233708
22	Phototransduction_Homo sapiens_hsa04744	1.58380193
23	RNA degradation_Homo sapiens_hsa03018	1.54171528
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.53865984
25	Fatty acid elongation_Homo sapiens_hsa00062	1.47983590
26	Base excision repair_Homo sapiens_hsa03410	1.38014886
27	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.29685278
28	Oxidative phosphorylation_Homo sapiens_hsa00190	1.29490521
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25987039
30	RNA transport_Homo sapiens_hsa03013	1.23022919
31	RNA polymerase_Homo sapiens_hsa03020	1.20063534
32	Regulation of autophagy_Homo sapiens_hsa04140	1.17439006
33	Parkinsons disease_Homo sapiens_hsa05012	1.15290812
34	Basal cell carcinoma_Homo sapiens_hsa05217	1.13947202
35	Peroxisome_Homo sapiens_hsa04146	1.13670205
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.11540178
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04488072
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04459957
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.99369999
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98105617
41	Sulfur metabolism_Homo sapiens_hsa00920	0.95364469
42	Fatty acid metabolism_Homo sapiens_hsa01212	0.94618684
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93124530
44	Oocyte meiosis_Homo sapiens_hsa04114	0.87687983
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83269182
46	Wnt signaling pathway_Homo sapiens_hsa04310	0.82616635
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82272115
48	Huntingtons disease_Homo sapiens_hsa05016	0.81974635
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81952213
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.78039571
51	Cell cycle_Homo sapiens_hsa04110	0.77608646
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.77065558
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76402488
54	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.75674302
55	ABC transporters_Homo sapiens_hsa02010	0.75639472
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75527863
57	Glutathione metabolism_Homo sapiens_hsa00480	0.74385029
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74163547
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.72966835
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.71828668
61	Caffeine metabolism_Homo sapiens_hsa00232	0.70498345
62	Purine metabolism_Homo sapiens_hsa00230	0.69386560
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66974597
64	Metabolic pathways_Homo sapiens_hsa01100	0.66906663
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65321553
66	Fatty acid degradation_Homo sapiens_hsa00071	0.63858858
67	p53 signaling pathway_Homo sapiens_hsa04115	0.63650623
68	Retinol metabolism_Homo sapiens_hsa00830	0.63200628
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61457379
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.61071840
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.60058589
72	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59223631
73	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.57558948
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.57518868
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.56799744
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56329822
77	Taste transduction_Homo sapiens_hsa04742	0.54715036
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54621127
79	Carbon metabolism_Homo sapiens_hsa01200	0.54428114
80	Insulin secretion_Homo sapiens_hsa04911	0.49930152
81	Lysine degradation_Homo sapiens_hsa00310	0.49262658
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47386560
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46924660
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.46050223
85	DNA replication_Homo sapiens_hsa03030	0.45200754
86	Alzheimers disease_Homo sapiens_hsa05010	0.44314114
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42220070
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40400395
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39171088
90	Olfactory transduction_Homo sapiens_hsa04740	0.37738421
91	Folate biosynthesis_Homo sapiens_hsa00790	0.37329637
92	Melanogenesis_Homo sapiens_hsa04916	0.36974038
93	Mineral absorption_Homo sapiens_hsa04978	0.35108066
94	Melanoma_Homo sapiens_hsa05218	0.34551532
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33542367
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32534613
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.32204295
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32090986
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31874451
100	Nicotine addiction_Homo sapiens_hsa05033	0.30992387

CCNJP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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