CCNL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)6.70407818
2regulation of gamma-delta T cell differentiation (GO:0045586)4.47295561
3semaphorin-plexin signaling pathway (GO:0071526)4.40908615
4positive regulation of gamma-delta T cell activation (GO:0046645)4.36045588
5regulation of ARF GTPase activity (GO:0032312)4.32717132
6regulation of gamma-delta T cell activation (GO:0046643)4.05859414
7valine metabolic process (GO:0006573)4.05274781
8L-phenylalanine catabolic process (GO:0006559)3.99219968
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.99219968
10histone H4 deacetylation (GO:0070933)3.93562654
11entrainment of circadian clock by photoperiod (GO:0043153)3.91804185
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88262898
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.88262898
14regulation of cholesterol homeostasis (GO:2000188)3.86557557
15establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.86292692
16mitochondrion transport along microtubule (GO:0047497)3.86292692
17histone H3-K9 demethylation (GO:0033169)3.80364036
18histone H3 deacetylation (GO:0070932)3.80246837
19alpha-linolenic acid metabolic process (GO:0036109)3.78475055
20regulation of histone H3-K27 methylation (GO:0061085)3.75103992
21positive regulation of histone deacetylation (GO:0031065)3.74758791
22mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.68144931
23positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.68144931
24stress granule assembly (GO:0034063)3.67400261
25establishment of mitochondrion localization (GO:0051654)3.62410242
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.50864430
27L-phenylalanine metabolic process (GO:0006558)3.50864430
28antigen processing and presentation of endogenous antigen (GO:0019883)3.49054931
29growth hormone receptor signaling pathway (GO:0060396)3.45422367
30endothelial cell chemotaxis (GO:0035767)3.40167834
31aromatic amino acid family catabolic process (GO:0009074)3.40089277
32negative regulation of cell size (GO:0045792)3.39684900
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.35984087
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.33769818
35histone H3-K4 trimethylation (GO:0080182)3.33298823
36positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.33044381
37bone trabecula formation (GO:0060346)3.31804263
38positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.28777729
39cellular response to growth hormone stimulus (GO:0071378)3.16709732
40positive thymic T cell selection (GO:0045059)3.16160661
41facial nerve structural organization (GO:0021612)3.15980425
42positive regulation of triglyceride biosynthetic process (GO:0010867)3.15252564
43lysine catabolic process (GO:0006554)3.14234459
44lysine metabolic process (GO:0006553)3.14234459
45complement activation, alternative pathway (GO:0006957)3.14037829
46photoperiodism (GO:0009648)3.12241445
47indole-containing compound catabolic process (GO:0042436)3.11600591
48indolalkylamine catabolic process (GO:0046218)3.11600591
49tryptophan catabolic process (GO:0006569)3.11600591
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.10558412
51tryptophan metabolic process (GO:0006568)3.09692577
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09283739
53urea metabolic process (GO:0019627)3.02381573
54urea cycle (GO:0000050)3.02381573
55regulation of protein activation cascade (GO:2000257)3.00829602
56kynurenine metabolic process (GO:0070189)3.00576988
57entrainment of circadian clock (GO:0009649)2.99934427
58negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.98712096
59positive regulation of CREB transcription factor activity (GO:0032793)2.97125930
60regulation of plasminogen activation (GO:0010755)2.96676447
61histone deubiquitination (GO:0016578)2.95933349
62activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.95360128
63cysteine metabolic process (GO:0006534)2.94416770
64tricarboxylic acid metabolic process (GO:0072350)2.93777504
65positive regulation of triglyceride metabolic process (GO:0090208)2.93700114
66negative regulation of macroautophagy (GO:0016242)2.93271184
67peptidyl-glutamic acid carboxylation (GO:0017187)2.93247881
68protein carboxylation (GO:0018214)2.93247881
69cell migration in hindbrain (GO:0021535)2.92461426
70positive regulation of fatty acid beta-oxidation (GO:0032000)2.92371866
71retrograde transport, endosome to Golgi (GO:0042147)2.90017843
72insulin-like growth factor receptor signaling pathway (GO:0048009)2.88709825
73negative regulation of fatty acid biosynthetic process (GO:0045717)2.88651137
74histone lysine demethylation (GO:0070076)2.88626503
75regulation of triglyceride catabolic process (GO:0010896)2.88452739
76acylglycerol homeostasis (GO:0055090)2.85974176
77triglyceride homeostasis (GO:0070328)2.85974176
78regulation of triglyceride biosynthetic process (GO:0010866)2.85847779
79cellular response to prostaglandin stimulus (GO:0071379)2.85466948
80poly(A)+ mRNA export from nucleus (GO:0016973)2.84998788
81glyoxylate metabolic process (GO:0046487)2.84069505
82phosphatidylglycerol biosynthetic process (GO:0006655)2.83980871
83regulation of complement activation (GO:0030449)2.83497164
84phospholipid homeostasis (GO:0055091)2.82790531
85snRNA processing (GO:0016180)2.81449086
86negative regulation of erythrocyte differentiation (GO:0045647)2.81414783
87plasma lipoprotein particle assembly (GO:0034377)2.80563569
88lung epithelium development (GO:0060428)2.80318136
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.80221521
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79953907
91negative regulation of cell killing (GO:0031342)2.79953907
92histone demethylation (GO:0016577)2.78177410
93actin filament depolymerization (GO:0030042)2.77357852
94snRNA metabolic process (GO:0016073)2.77348816
95cytoplasmic mRNA processing body assembly (GO:0033962)2.76190442
96positive regulation of nuclease activity (GO:0032075)2.74411181
97regulation of cholesterol metabolic process (GO:0090181)2.74215153
98DNA damage induced protein phosphorylation (GO:0006975)2.71799978
99regulation of ARF protein signal transduction (GO:0032012)2.71045909
100bile acid biosynthetic process (GO:0006699)2.70373774
101dicarboxylic acid biosynthetic process (GO:0043650)2.70030681
102protein-lipid complex assembly (GO:0065005)2.69122772
1032-oxoglutarate metabolic process (GO:0006103)2.69039044
104negative T cell selection (GO:0043383)2.68674757
105cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68247176
106positive regulation of glycolytic process (GO:0045821)2.67317898
107phospholipid efflux (GO:0033700)2.67106421
108cell-cell junction maintenance (GO:0045217)2.66744897
109regulation of fatty acid beta-oxidation (GO:0031998)2.66636391
110negative regulation of autophagy (GO:0010507)2.66494731
111retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65781039
112positive T cell selection (GO:0043368)2.65066919
113regulation of axon extension involved in axon guidance (GO:0048841)2.64748096
114negative thymic T cell selection (GO:0045060)2.63256002
115Golgi transport vesicle coating (GO:0048200)2.63226260
116COPI coating of Golgi vesicle (GO:0048205)2.63226260
117nitrogen cycle metabolic process (GO:0071941)2.62219473
118intestinal cholesterol absorption (GO:0030299)2.62105432
119positive regulation of glycogen biosynthetic process (GO:0045725)2.60340256
120regulation of extracellular matrix disassembly (GO:0010715)2.59846346
121negative regulation of sterol transport (GO:0032372)2.59370151
122negative regulation of cholesterol transport (GO:0032375)2.59370151
123head development (GO:0060322)2.58746169
124homocysteine metabolic process (GO:0050667)2.57913188
125positive regulation of mitochondrial membrane permeability (GO:0035794)2.57891608
126thymic T cell selection (GO:0045061)2.57763468
127histone H3-K4 methylation (GO:0051568)2.56884601
128regulation of triglyceride metabolic process (GO:0090207)2.54498245
129dosage compensation (GO:0007549)2.53881142
130regulation of fibrinolysis (GO:0051917)2.52682662
131regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.52578302
132lung vasculature development (GO:0060426)2.52062523
133regulation of glycolytic process (GO:0006110)2.51683470
134exocrine pancreas development (GO:0031017)2.51471440
135negative regulation of fatty acid transport (GO:2000192)2.51274381
136positive regulation of blood vessel endothelial cell migration (GO:0043536)2.50586200
137positive regulation of lipid catabolic process (GO:0050996)2.50389830
138positive regulation of dendrite morphogenesis (GO:0050775)2.49930996
139regulation of cholesterol storage (GO:0010885)2.49717406
140positive regulation of sterol transport (GO:0032373)2.49600307
141positive regulation of cholesterol transport (GO:0032376)2.49600307
142JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49378781
143cell proliferation involved in metanephros development (GO:0072203)2.49215379
144fatty acid transmembrane transport (GO:1902001)2.48724695
145negative regulation of fibrinolysis (GO:0051918)2.48153055
146mesenchyme morphogenesis (GO:0072132)2.47945199
147positive regulation of protein kinase C signaling (GO:0090037)2.47773747
148convergent extension (GO:0060026)2.47647568
149bile acid metabolic process (GO:0008206)2.47502756
150histone H4-K12 acetylation (GO:0043983)2.47433363
151positive regulation of smoothened signaling pathway (GO:0045880)2.47297081
152ethanol oxidation (GO:0006069)2.46487912
153T cell selection (GO:0045058)2.45195502
154protein dealkylation (GO:0008214)2.44183076
155protein demethylation (GO:0006482)2.44183076
156peptidyl-lysine trimethylation (GO:0018023)2.44052598
157response to muramyl dipeptide (GO:0032495)2.43525959
158sulfate transmembrane transport (GO:1902358)2.43281705
159positive regulation of glycogen metabolic process (GO:0070875)2.42885756
160chondroitin sulfate catabolic process (GO:0030207)2.42082995
161positive regulation of fatty acid oxidation (GO:0046321)2.41806741
162positive regulation of cholesterol efflux (GO:0010875)2.41670809
163histone deacetylation (GO:0016575)2.40619274
164reverse cholesterol transport (GO:0043691)2.40297740
165basement membrane organization (GO:0071711)2.40223021
166negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.40159352
167high-density lipoprotein particle remodeling (GO:0034375)2.39945470
168plasma lipoprotein particle clearance (GO:0034381)2.39205827
169protein retention in ER lumen (GO:0006621)2.38762672
170regulation of nuclease activity (GO:0032069)2.37559730
171cranial nerve morphogenesis (GO:0021602)2.37386777
172sulfur amino acid catabolic process (GO:0000098)2.36923456
173regulation of T cell tolerance induction (GO:0002664)2.36388179
174synaptic vesicle docking involved in exocytosis (GO:0016081)2.36358060
175negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.35940977
176positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35532494
177low-density lipoprotein particle clearance (GO:0034383)2.34850077
178regulation of axon guidance (GO:1902667)2.34838113
179cochlea morphogenesis (GO:0090103)2.33966263
180carnitine shuttle (GO:0006853)2.32945553
181fatty acid beta-oxidation (GO:0006635)2.32880644
182amino-acid betaine metabolic process (GO:0006577)2.32374134
183positive regulation of p38MAPK cascade (GO:1900745)2.32076772
184cell volume homeostasis (GO:0006884)2.31666175
185positive regulation of protein deacetylation (GO:0090312)2.30787369
186nephron epithelium morphogenesis (GO:0072088)2.28883985
187nephron tubule morphogenesis (GO:0072078)2.28883985
188endoplasmic reticulum unfolded protein response (GO:0030968)2.28444531
189adherens junction assembly (GO:0034333)2.28232279
190maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.28055162
191negative regulation of smooth muscle cell migration (GO:0014912)2.27040629
192maintenance of protein localization in organelle (GO:0072595)2.26662415
193maintenance of protein location in nucleus (GO:0051457)2.25733916
194histone H3-K9 modification (GO:0061647)2.25451274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.47806168
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.08517507
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.75808089
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.49983257
5GATA1_22025678_ChIP-Seq_K562_Human3.27560342
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14665274
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13729687
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12412126
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.08444564
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63011840
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.58213930
12CLOCK_20551151_ChIP-Seq_293T_Human2.55970217
13MYC_22102868_ChIP-Seq_BL_Human2.46696540
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40144421
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.29118519
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28614952
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.18959723
18RUNX_20019798_ChIP-Seq_JUKART_Human2.14524501
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.13188931
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09655092
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08831049
22TCF7_22412390_ChIP-Seq_EML_Mouse2.08559348
23EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.05040238
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04485057
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01212431
26* KDM2B_26808549_Chip-Seq_DND41_Human1.94871249
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.93795801
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93255450
29VDR_21846776_ChIP-Seq_THP-1_Human1.91439115
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88793417
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88109119
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84391664
33SCL_19346495_ChIP-Seq_HPC-7_Human1.83598911
34MAF_26560356_Chip-Seq_TH1_Human1.81516718
35* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78866794
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75908957
37P68_20966046_ChIP-Seq_HELA_Human1.75897902
38SMC4_20622854_ChIP-Seq_HELA_Human1.74273127
39UTX_26944678_Chip-Seq_JUKART_Human1.72389112
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68230340
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68029863
42* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.67393922
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66274579
44* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65372326
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63131365
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62359822
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.61450625
48TP53_22127205_ChIP-Seq_IMR90_Human1.60992047
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.59656396
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59507215
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59234741
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.58130444
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57546231
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.56706347
55MYB_26560356_Chip-Seq_TH1_Human1.53625734
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52021409
57GATA1_19941826_ChIP-Seq_K562_Human1.51375792
58DROSHA_22980978_ChIP-Seq_HELA_Human1.50723609
59CTCF_27219007_Chip-Seq_Bcells_Human1.48952912
60* FOXA2_19822575_ChIP-Seq_HepG2_Human1.48882202
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45571478
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.45047483
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42821534
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42230026
65MYB_26560356_Chip-Seq_TH2_Human1.42204020
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.41929100
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39355188
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37974002
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37470696
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.37160305
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37080487
72VDR_24763502_ChIP-Seq_THP-1_Human1.36530111
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34893094
74LXR_22292898_ChIP-Seq_THP-1_Human1.30093712
75* ELF1_20517297_ChIP-Seq_JURKAT_Human1.30050302
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.29700356
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29142289
78* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29020914
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27107097
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26724736
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26510481
82SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25837776
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25799198
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25027806
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24053943
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23319887
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22050093
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20338003
89* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18649883
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.18492638
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18486691
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17536329
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.17526064
94BCL6_27268052_Chip-Seq_Bcells_Human1.17398755
95NCOR1_26117541_ChIP-Seq_K562_Human1.17075107
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.15085838
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.15085838
98MAF_26560356_Chip-Seq_TH2_Human1.15073590
99* TP63_22573176_ChIP-Seq_HFKS_Human1.14204503
100* RARB_27405468_Chip-Seq_BRAIN_Mouse1.13719774
101TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13335898
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13185656
103BCOR_27268052_Chip-Seq_Bcells_Human1.13060457
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.12613000
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12320973
106RACK7_27058665_Chip-Seq_MCF-7_Human1.12318175
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12143040
108* PHF8_20622854_ChIP-Seq_HELA_Human1.11663226
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.11283395
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11275144
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11101218
112GATA3_27048872_Chip-Seq_THYMUS_Human1.10547710
113RARA_24833708_ChIP-Seq_LIVER_Mouse1.10356708
114GATA6_25053715_ChIP-Seq_YYC3_Human1.10025482
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09192084
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09068770
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08116569
118RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07307507
119KDM2B_26808549_Chip-Seq_K562_Human1.07001620
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05926475
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05625082
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05202221
123MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04307953
124GATA2_19941826_ChIP-Seq_K562_Human1.03738047
125CIITA_25753668_ChIP-Seq_RAJI_Human1.03492974
126* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02827123
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02761866
128TP53_23651856_ChIP-Seq_MEFs_Mouse1.02206962
129RUNX1_27514584_Chip-Seq_MCF-7_Human1.02123393
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01926935
131* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00056030
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99720517
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99662990
134RUNX1_22412390_ChIP-Seq_EML_Mouse0.99467554
135* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99105979
136ZNF263_19887448_ChIP-Seq_K562_Human0.98122524
137* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98048798
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97842081
139RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97579526
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97513932
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97280968
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96637293
143IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96520564
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96388199
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95807668
146* E2F1_20622854_ChIP-Seq_HELA_Human0.95392840
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95016712
148CREB1_26743006_Chip-Seq_LNCaP_Human0.94781901
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.93532235
150SPI1_23127762_ChIP-Seq_K562_Human0.90589363
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89945158
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89920219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.34546118
2MP0005360_urolithiasis3.80555014
3MP0005365_abnormal_bile_salt3.80498994
4MP0009384_cardiac_valve_regurgitation3.72648805
5MP0003172_abnormal_lysosome_physiology3.53464801
6MP0005058_abnormal_lysosome_morphology3.19693466
7MP0003252_abnormal_bile_duct2.89372351
8MP0005085_abnormal_gallbladder_physiolo2.81680251
9MP0001958_emphysema2.74198191
10MP0003300_gastrointestinal_ulcer2.55177012
11MP0005503_abnormal_tendon_morphology2.49972588
12MP0010329_abnormal_lipoprotein_level2.40795348
13MP0008260_abnormal_autophagy2.37279232
14MP0001666_abnormal_nutrient_absorption2.27177572
15MP0003279_aneurysm2.26558753
16MP0001502_abnormal_circadian_rhythm2.07499227
17MP0002249_abnormal_larynx_morphology2.01673287
18MP0003763_abnormal_thymus_physiology2.01514348
19MP0002166_altered_tumor_susceptibility2.00697725
20MP0004858_abnormal_nervous_system1.99627311
21MP0000685_abnormal_immune_system1.97746606
22MP0001299_abnormal_eye_distance/1.94916677
23MP0000609_abnormal_liver_physiology1.94035594
24MP0004185_abnormal_adipocyte_glucose1.93481072
25MP0010234_abnormal_vibrissa_follicle1.91816226
26MP0005083_abnormal_biliary_tract1.88765088
27MP0002254_reproductive_system_inflammat1.81443861
28MP0008875_abnormal_xenobiotic_pharmacok1.81215575
29MP0002138_abnormal_hepatobiliary_system1.79685983
30MP0001348_abnormal_lacrimal_gland1.78322349
31MP0005670_abnormal_white_adipose1.75959218
32MP0004859_abnormal_synaptic_plasticity1.75937255
33MP0003705_abnormal_hypodermis_morpholog1.75754274
34MP0009840_abnormal_foam_cell1.71413171
35MP0005666_abnormal_adipose_tissue1.71338245
36MP0000013_abnormal_adipose_tissue1.69914423
37MP0001270_distended_abdomen1.68618119
38MP0003868_abnormal_feces_composition1.67063003
39MP0005220_abnormal_exocrine_pancreas1.66697658
40MP0003191_abnormal_cellular_cholesterol1.65376726
41MP0004130_abnormal_muscle_cell1.60863469
42MP0000751_myopathy1.58975125
43MP0002118_abnormal_lipid_homeostasis1.56189523
44MP0005409_darkened_coat_color1.52151735
45MP0000733_abnormal_muscle_development1.51325992
46MP0009278_abnormal_bone_marrow1.51067706
47MP0008961_abnormal_basal_metabolism1.49926256
48MP0005375_adipose_tissue_phenotype1.49759991
49MP0001873_stomach_inflammation1.49501762
50MP0000767_abnormal_smooth_muscle1.47119148
51MP0003115_abnormal_respiratory_system1.44572702
52MP0010030_abnormal_orbit_morphology1.43199114
53MP0002971_abnormal_brown_adipose1.42836019
54MP0010368_abnormal_lymphatic_system1.41982597
55MP0001790_abnormal_immune_system1.40772926
56MP0005387_immune_system_phenotype1.40772926
57MP0002089_abnormal_postnatal_growth/wei1.39946308
58MP0001800_abnormal_humoral_immune1.39488393
59MP0003091_abnormal_cell_migration1.37210630
60MP0006138_congestive_heart_failure1.37159771
61MP0002932_abnormal_joint_morphology1.36069350
62MP0005332_abnormal_amino_acid1.35572777
63MP0000537_abnormal_urethra_morphology1.34504192
64MP0000003_abnormal_adipose_tissue1.31054649
65MP0000566_synostosis1.30818314
66MP0008438_abnormal_cutaneous_collagen1.29493700
67MP0003329_amyloid_beta_deposits1.28449961
68MP0009643_abnormal_urine_homeostasis1.27567907
69MP0002928_abnormal_bile_duct1.26365230
70MP0003122_maternal_imprinting1.23652111
71MP0001835_abnormal_antigen_presentation1.22049040
72MP0002006_tumorigenesis1.21877682
73MP0003303_peritoneal_inflammation1.19570016
74MP0004947_skin_inflammation1.19535054
75MP0002108_abnormal_muscle_morphology1.18939847
76MP0000678_abnormal_parathyroid_gland1.18802638
77MP0002116_abnormal_craniofacial_bone1.17906844
78MP0005671_abnormal_response_to1.17789034
79MP0003436_decreased_susceptibility_to1.17372165
80MP0003942_abnormal_urinary_system1.16661818
81MP0010155_abnormal_intestine_physiology1.16020780
82MP0004264_abnormal_extraembryonic_tissu1.15048397
83MP0005257_abnormal_intraocular_pressure1.13049305
84MP0005076_abnormal_cell_differentiation1.09188606
85MP0000534_abnormal_ureter_morphology1.08890714
86MP0003866_abnormal_defecation1.08671928
87MP0005334_abnormal_fat_pad1.05745054
88MP0000858_altered_metastatic_potential1.04269725
89MP0003385_abnormal_body_wall1.03591084
90MP0002060_abnormal_skin_morphology1.03319569
91MP0002653_abnormal_ependyma_morphology1.02338777
92MP0002925_abnormal_cardiovascular_devel1.01826226
93MP0000598_abnormal_liver_morphology1.00484188
94MP0005275_abnormal_skin_tensile0.99956855
95MP0001879_abnormal_lymphatic_vessel0.99808032
96MP0009763_increased_sensitivity_to0.98781825
97MP0003690_abnormal_glial_cell0.98235829
98MP0005464_abnormal_platelet_physiology0.98232112
99MP0004272_abnormal_basement_membrane0.97743665
100MP0001944_abnormal_pancreas_morphology0.96743434
101MP0002723_abnormal_immune_serum0.96281498
102MP0002452_abnormal_antigen_presenting0.95682952
103MP0003566_abnormal_cell_adhesion0.95596952
104MP0004019_abnormal_vitamin_homeostasis0.95063069
105MP0002398_abnormal_bone_marrow0.93544869
106MP0002136_abnormal_kidney_physiology0.93317843
107MP0002420_abnormal_adaptive_immunity0.91092438
108MP0005319_abnormal_enzyme/_coenzyme0.90730204
109MP0002114_abnormal_axial_skeleton0.89289371
110MP0003045_fibrosis0.89156477
111MP0001819_abnormal_immune_cell0.88849145
112MP0000703_abnormal_thymus_morphology0.88476539
113MP0008469_abnormal_protein_level0.87798636
114MP0002078_abnormal_glucose_homeostasis0.87363622
115MP0003656_abnormal_erythrocyte_physiolo0.87313559
116MP0004197_abnormal_fetal_growth/weight/0.86932324
117MP0002933_joint_inflammation0.85991406
118MP0000569_abnormal_digit_pigmentation0.85766533
119MP0001614_abnormal_blood_vessel0.85570771
120MP0003183_abnormal_peptide_metabolism0.84879501
121MP0003948_abnormal_gas_homeostasis0.84798850
122MP0003195_calcinosis0.84328198
123MP0001243_abnormal_dermal_layer0.83893924
124MP0002396_abnormal_hematopoietic_system0.83823444
125MP0001845_abnormal_inflammatory_respons0.82936340
126MP0000716_abnormal_immune_system0.81974322
127MP0005584_abnormal_enzyme/coenzyme_acti0.81741953
128MP0005508_abnormal_skeleton_morphology0.80894213
129MP0001175_abnormal_lung_morphology0.80810723
130MP0009672_abnormal_birth_weight0.80759996
131MP0001661_extended_life_span0.80590839
132MP0008995_early_reproductive_senescence0.80083574
133MP0005000_abnormal_immune_tolerance0.79221936
134MP0003453_abnormal_keratinocyte_physiol0.78926759
135MP0002822_catalepsy0.77503061
136MP0002419_abnormal_innate_immunity0.77256831
137MP0009764_decreased_sensitivity_to0.77163474
138MP0005025_abnormal_response_to0.77056785
139MP0000689_abnormal_spleen_morphology0.76380904
140MP0000778_abnormal_nervous_system0.76283015
141MP0000428_abnormal_craniofacial_morphol0.75385395
142MP0001853_heart_inflammation0.75370309
143MP0005023_abnormal_wound_healing0.75337644
144MP0002722_abnormal_immune_system0.75281770
145MP0001849_ear_inflammation0.74092589
146MP0003724_increased_susceptibility_to0.74030221
147MP0002970_abnormal_white_adipose0.74004824
148MP0005499_abnormal_olfactory_system0.73915813
149MP0005394_taste/olfaction_phenotype0.73915813
150MP0009115_abnormal_fat_cell0.73082646
151MP0005451_abnormal_body_composition0.72845423
152MP0006054_spinal_hemorrhage0.72090639
153MP0010630_abnormal_cardiac_muscle0.70939883
154MP0002128_abnormal_blood_circulation0.70403533
155MP0002115_abnormal_skeleton_extremities0.69284552
156MP0005621_abnormal_cell_physiology0.69075100
157MP0003634_abnormal_glial_cell0.69025156
158MP0003935_abnormal_craniofacial_develop0.68089691
159MP0000432_abnormal_head_morphology0.67106687
160MP0002009_preneoplasia0.66980666
161MP0000759_abnormal_skeletal_muscle0.65485507
162MP0002092_abnormal_eye_morphology0.64635567
163MP0003938_abnormal_ear_development0.63831692
164MP0004087_abnormal_muscle_fiber0.62805914
165MP0000266_abnormal_heart_morphology0.62253300
166MP0005397_hematopoietic_system_phenotyp0.62058477
167MP0001545_abnormal_hematopoietic_system0.62058477

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)4.74217845
2Broad face (HP:0000283)4.44119028
3Protrusio acetabuli (HP:0003179)4.29635215
4Biconcave vertebral bodies (HP:0004586)4.25334327
5Obstructive sleep apnea (HP:0002870)4.06163164
6Deep venous thrombosis (HP:0002625)4.03582319
7J-shaped sella turcica (HP:0002680)3.95263808
8Abnormality of the fingertips (HP:0001211)3.83941790
9Intrahepatic cholestasis (HP:0001406)3.34075221
10Xanthomatosis (HP:0000991)3.32648794
11Hypoglycemic coma (HP:0001325)3.23344043
12Aortic regurgitation (HP:0001659)3.19936297
13Stridor (HP:0010307)3.12334986
14Broad metatarsal (HP:0001783)3.11282242
15Myocardial infarction (HP:0001658)3.04847159
16Premature rupture of membranes (HP:0001788)2.99139303
17Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95592025
18Complement deficiency (HP:0004431)2.90895619
19Ketosis (HP:0001946)2.88144329
20Flat acetabular roof (HP:0003180)2.85597801
21Hypoglycemic seizures (HP:0002173)2.84386868
22Upper limb amyotrophy (HP:0009129)2.83765192
23Distal upper limb amyotrophy (HP:0007149)2.83765192
24Urinary glycosaminoglycan excretion (HP:0003541)2.76509224
25Mucopolysacchariduria (HP:0008155)2.76509224
26Hyperlipoproteinemia (HP:0010980)2.76333537
27T lymphocytopenia (HP:0005403)2.75168406
28Prolonged partial thromboplastin time (HP:0003645)2.72455326
29Abnormality of the common coagulation pathway (HP:0010990)2.68167742
30Joint stiffness (HP:0001387)2.64122294
31Broad palm (HP:0001169)2.62842837
32Hand muscle atrophy (HP:0009130)2.61452055
33Metaphyseal cupping (HP:0003021)2.59703070
34Abnormality of T cell number (HP:0011839)2.58511849
35Dysostosis multiplex (HP:0000943)2.58044745
36Abnormality of polysaccharide metabolism (HP:0011012)2.54130149
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54130149
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54130149
39Epidermoid cyst (HP:0200040)2.51425064
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.50182411
41Cerebral aneurysm (HP:0004944)2.49483958
42Mitral regurgitation (HP:0001653)2.48725560
43Ketoacidosis (HP:0001993)2.48553581
44Deformed sella turcica (HP:0002681)2.47670817
45Aortic aneurysm (HP:0004942)2.47335346
46Spinal cord lesions (HP:0100561)2.45751093
47Syringomyelia (HP:0003396)2.45751093
48Atelectasis (HP:0100750)2.45006120
49Bladder diverticulum (HP:0000015)2.44430777
50Nuclear cataract (HP:0100018)2.42971982
51Interstitial pulmonary disease (HP:0006530)2.41089914
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39586731
53Hypoplasia of the thymus (HP:0000778)2.37542791
54Aneurysm (HP:0002617)2.37497501
55Colitis (HP:0002583)2.33465558
56Macroorchidism (HP:0000053)2.32194525
57Gingival bleeding (HP:0000225)2.30924775
58Symptomatic seizures (HP:0011145)2.30835812
59Bronchomalacia (HP:0002780)2.30742940
60Mitral stenosis (HP:0001718)2.30077574
61Atrophic scars (HP:0001075)2.28763329
62Hyperinsulinemic hypoglycemia (HP:0000825)2.27977221
63Dislocated radial head (HP:0003083)2.27141353
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.26284454
65Hypoalphalipoproteinemia (HP:0003233)2.25569300
66Abnormality of dentin (HP:0010299)2.24685519
67Recurrent viral infections (HP:0004429)2.22615535
68Hyperglycinuria (HP:0003108)2.20695274
69Bell-shaped thorax (HP:0001591)2.17742538
70Flared iliac wings (HP:0002869)2.16995178
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16414949
72Narrow palate (HP:0000189)2.15726926
73Abnormality of the radial head (HP:0003995)2.14452946
74Hypobetalipoproteinemia (HP:0003563)2.13374581
75Distal lower limb amyotrophy (HP:0008944)2.13360699
76Wide nose (HP:0000445)2.12739231
77Joint hemorrhage (HP:0005261)2.09116332
78Autoimmune thrombocytopenia (HP:0001973)2.08578880
79Pointed chin (HP:0000307)2.05335858
80Exercise-induced myalgia (HP:0003738)2.04602285
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04255597
82Hyperammonemia (HP:0001987)2.03230204
83Ankle clonus (HP:0011448)2.03069679
84Spinal canal stenosis (HP:0003416)2.02521517
85Hypolipoproteinemia (HP:0010981)2.00470809
86Panhypogammaglobulinemia (HP:0003139)2.00198011
87Vertebral arch anomaly (HP:0008438)1.99606582
88Abnormality of the intrinsic pathway (HP:0010989)1.98700068
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97575526
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.97450167
91Abnormality of glycine metabolism (HP:0010895)1.96265200
92Abnormality of serine family amino acid metabolism (HP:0010894)1.96265200
93Inflammation of the large intestine (HP:0002037)1.96127653
94Esophageal varix (HP:0002040)1.95247653
95Wormian bones (HP:0002645)1.95107932
96Long toe (HP:0010511)1.94915210
97Ectopia lentis (HP:0001083)1.94094181
98Gastrointestinal inflammation (HP:0004386)1.92306898
99Thin ribs (HP:0000883)1.92222070
100Arterial tortuosity (HP:0005116)1.92169564
101Turricephaly (HP:0000262)1.91575535
102Abnormality of complement system (HP:0005339)1.91357331
103Acanthocytosis (HP:0001927)1.90820394
104Pseudobulbar signs (HP:0002200)1.90751789
105Hypercholesterolemia (HP:0003124)1.89541764
106Mitral valve prolapse (HP:0001634)1.89501770
107Blue sclerae (HP:0000592)1.88692471
108Polycythemia (HP:0001901)1.87712019
109Recurrent fungal infections (HP:0002841)1.86648089
110Difficulty climbing stairs (HP:0003551)1.84897992
111Shallow orbits (HP:0000586)1.84424129
112Mildly elevated creatine phosphokinase (HP:0008180)1.83331065
113Abnormality of the aortic arch (HP:0012303)1.83270435
114Broad distal phalanx of finger (HP:0009836)1.82948007
115Cupped ribs (HP:0000887)1.82596598
116Abnormality of the acetabulum (HP:0003170)1.82255546
117Neonatal short-limb short stature (HP:0008921)1.82175610
118Aortic dissection (HP:0002647)1.81928380
119Hydroxyprolinuria (HP:0003080)1.81361981
120Abnormality of proline metabolism (HP:0010907)1.81361981
121Dilatation of the ascending aorta (HP:0005111)1.81306164
122Hyperglycemia (HP:0003074)1.81101710
123Heterotopia (HP:0002282)1.81101656
124Increased IgE level (HP:0003212)1.80442754
125Gastrointestinal infarctions (HP:0005244)1.80249532
126Thin bony cortex (HP:0002753)1.79372525
127Abnormality of skull ossification (HP:0002703)1.78864486
128Camptodactyly of toe (HP:0001836)1.78752882
129Abnormality of fatty-acid metabolism (HP:0004359)1.78201841
130Abnormality of endocrine pancreas physiology (HP:0012093)1.77956572
131Abnormality of the pancreatic islet cells (HP:0006476)1.77956572
13211 pairs of ribs (HP:0000878)1.77507016
133Lymphangioma (HP:0100764)1.76822204
134Vascular tortuosity (HP:0004948)1.76392335
135Chronic otitis media (HP:0000389)1.73948383
136Rectal prolapse (HP:0002035)1.73906877
137Rhizomelia (HP:0008905)1.73310347
138Emphysema (HP:0002097)1.73071451
139Abnormality of the calcaneus (HP:0008364)1.72730550
140Hemorrhage of the eye (HP:0011885)1.72689986
141Peritonitis (HP:0002586)1.72221799
142Periodontitis (HP:0000704)1.72081929
143Ulnar bowing (HP:0003031)1.71550019
144Skin nodule (HP:0200036)1.71430786
145Spastic diplegia (HP:0001264)1.71412150
146Vitreoretinal degeneration (HP:0000655)1.71379155
147Back pain (HP:0003418)1.70463927
148Alacrima (HP:0000522)1.70408565
149Abnormality of the humeroradial joint (HP:0100744)1.69866958
150Anal stenosis (HP:0002025)1.69542345
151Inguinal hernia (HP:0000023)1.68554580
152Poikilocytosis (HP:0004447)1.67211111
153Abnormality of T cells (HP:0002843)1.66397846
154Supernumerary nipples (HP:0002558)1.65856047
155Agammaglobulinemia (HP:0004432)1.65687315
156Entropion (HP:0000621)1.65627422
157Fragile skin (HP:0001030)1.65583203
158Short nail (HP:0001799)1.65463572
159Abnormality of purine metabolism (HP:0004352)1.65359135
160Long palpebral fissure (HP:0000637)1.65281526
161Reticulocytosis (HP:0001923)1.64883034
162Hyperbilirubinemia (HP:0002904)1.64819832
163Abnormality of the sella turcica (HP:0002679)1.64569215
164Enlarged penis (HP:0000040)1.63368506
165Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61786796
166Hammertoe (HP:0001765)1.61418318
167Supernumerary ribs (HP:0005815)1.61090520
168Papilledema (HP:0001085)1.60901750
169Abnormal hair laboratory examination (HP:0003328)1.60629460
170Disproportionate tall stature (HP:0001519)1.60366582
171Persistence of primary teeth (HP:0006335)1.60301200
172Neoplasm of the heart (HP:0100544)1.59812487
173Hyperglycinemia (HP:0002154)1.58748175
174Enlarged kidneys (HP:0000105)1.58572487
175Renovascular hypertension (HP:0100817)1.57796800
176Long eyelashes (HP:0000527)1.57583853
177Radial bowing (HP:0002986)1.57309267
178Hyperacusis (HP:0010780)1.55695906
179Spontaneous hematomas (HP:0007420)1.55393911
180Ureteral stenosis (HP:0000071)1.55152161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.43194890
2ERN13.32400308
3FGFR43.17598296
4TRIB32.93346969
5NTRK12.47193690
6MAP4K12.39888360
7MAP2K62.38768801
8PKN22.33160259
9MAP3K102.25757436
10INSRR2.25728839
11CAMK1D2.22194620
12BRD42.12547390
13MAP3K62.12476939
14TYK22.09249314
15CAMK1G2.07740511
16RIPK11.92889883
17PTK61.92160036
18TAOK31.88443595
19EPHB11.86159688
20MAP3K131.85550177
21JAK31.84242303
22JAK11.80720876
23SIK21.73469396
24FGFR31.63671132
25MAP3K71.62811880
26FLT31.57830720
27CDK121.57671881
28MAP2K41.52186202
29MAP3K141.47633022
30EEF2K1.46319578
31TTN1.44144469
32MET1.33727075
33ITK1.31835538
34FGFR21.30263944
35TIE11.29014167
36PRPF4B1.28673690
37EPHA31.23166783
38IKBKE1.22858410
39JAK21.19896691
40TGFBR21.18182943
41LATS11.15874335
42PRKAA21.14987368
43PDGFRA1.14955853
44MARK21.13302468
45ZAP701.11865596
46CSK1.10642050
47MARK31.07626219
48PDGFRB1.06995833
49NLK1.05327891
50DDR21.04183785
51STK101.02885768
52MAPK151.00966576
53MTOR0.99752888
54TBK10.98760252
55MAP2K30.98442415
56RPS6KA20.96747046
57SMG10.94463498
58TNK20.94143349
59BCKDK0.93804934
60DYRK1B0.92219754
61NTRK20.89961779
62PTK20.89427322
63SIK30.88875991
64HIPK20.87976142
65CDK60.86171007
66TXK0.84476359
67BTK0.83567559
68MARK10.82663393
69LCK0.82173136
70CAMKK10.81216574
71MAPK110.81025474
72CSF1R0.80720485
73DMPK0.75156066
74IRAK30.75116696
75LRRK20.74787379
76PIK3CG0.74139343
77HCK0.73856508
78BMX0.73275805
79CHUK0.73211975
80RPS6KL10.72078254
81RPS6KC10.72078254
82PRKD30.70265640
83RET0.69477764
84GRK60.68708719
85EPHA20.65169580
86MAP2K20.64617930
87KIT0.64512486
88SGK30.64304272
89FGFR10.62435952
90PRKD20.61793140
91WNK10.61209380
92NTRK30.60214688
93PRKD10.58534576
94CDK40.58445087
95PRKCH0.57654180
96RPS6KA60.56585774
97AKT30.53082821
98CDK90.52694811
99MAPK80.52602133
100PRKAA10.51456145
101PTK2B0.49698359
102CDC42BPA0.49652166
103PRKCQ0.48944081
104PAK20.48830138
105KDR0.48430096
106MAPK30.48216408
107MAPK100.47954130
108CSNK1A1L0.46524686
109IKBKB0.46401670
110IGF1R0.46304989
111MAPK70.45769810
112TEC0.45007958
113PDPK10.44436685
114PDK10.44080023
115STK380.43911588
116MAPK120.42676667
117ERBB20.41981648
118ICK0.41963071
119KSR20.40655095
120TYRO30.37826520
121ABL10.37387004
122CAMK40.36807662
123SYK0.36651951
124MST1R0.36193228
125SRC0.35832529
126RPS6KA40.34721187
127INSR0.34363103
128WNK40.34269242
129PRKCZ0.33382936
130NEK20.33325920
131BLK0.32220846
132PAK60.30596126
133MAPK10.30261194

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.12618946
2Nitrogen metabolism_Homo sapiens_hsa009103.59341679
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.68244146
4Lysine degradation_Homo sapiens_hsa003102.58926697
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.49614776
6Caffeine metabolism_Homo sapiens_hsa002322.24645441
7Fatty acid degradation_Homo sapiens_hsa000712.23454839
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.07014313
9Tryptophan metabolism_Homo sapiens_hsa003802.06026990
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.04232468
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97823939
12PPAR signaling pathway_Homo sapiens_hsa033201.93303027
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88384709
14VEGF signaling pathway_Homo sapiens_hsa043701.87724393
15Complement and coagulation cascades_Homo sapiens_hsa046101.87354571
16Arginine biosynthesis_Homo sapiens_hsa002201.86503740
17Primary immunodeficiency_Homo sapiens_hsa053401.85801482
18ABC transporters_Homo sapiens_hsa020101.77414982
19Selenocompound metabolism_Homo sapiens_hsa004501.71617043
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66487758
21Staphylococcus aureus infection_Homo sapiens_hsa051501.63252358
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61496531
23Fatty acid metabolism_Homo sapiens_hsa012121.56197453
24Insulin resistance_Homo sapiens_hsa049311.53897770
25Neurotrophin signaling pathway_Homo sapiens_hsa047221.46544511
26Phospholipase D signaling pathway_Homo sapiens_hsa040721.46275241
27Bile secretion_Homo sapiens_hsa049761.45418204
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43366652
29GnRH signaling pathway_Homo sapiens_hsa049121.42779705
30Propanoate metabolism_Homo sapiens_hsa006401.39241391
31Non-small cell lung cancer_Homo sapiens_hsa052231.31976490
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30370584
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29578013
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27548762
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22423615
36Peroxisome_Homo sapiens_hsa041461.21253366
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.20066090
38ErbB signaling pathway_Homo sapiens_hsa040121.17675018
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16993305
40B cell receptor signaling pathway_Homo sapiens_hsa046621.14947406
41Fat digestion and absorption_Homo sapiens_hsa049751.11490519
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.09059581
43T cell receptor signaling pathway_Homo sapiens_hsa046601.09028711
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07405645
45Glycerolipid metabolism_Homo sapiens_hsa005611.05413409
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04790535
47Glioma_Homo sapiens_hsa052141.04180829
48Inositol phosphate metabolism_Homo sapiens_hsa005621.01533094
49Butanoate metabolism_Homo sapiens_hsa006501.01422728
50beta-Alanine metabolism_Homo sapiens_hsa004100.98744306
51Fatty acid biosynthesis_Homo sapiens_hsa000610.95827839
52Acute myeloid leukemia_Homo sapiens_hsa052210.95201295
53Axon guidance_Homo sapiens_hsa043600.94541967
54Estrogen signaling pathway_Homo sapiens_hsa049150.90045892
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89928188
56Type II diabetes mellitus_Homo sapiens_hsa049300.89796438
57Osteoclast differentiation_Homo sapiens_hsa043800.87214832
58Endometrial cancer_Homo sapiens_hsa052130.86573113
59Notch signaling pathway_Homo sapiens_hsa043300.85801800
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85134080
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84121105
62Protein digestion and absorption_Homo sapiens_hsa049740.83609124
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83173513
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80108762
65AMPK signaling pathway_Homo sapiens_hsa041520.79545450
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78829142
67Measles_Homo sapiens_hsa051620.78762205
68Small cell lung cancer_Homo sapiens_hsa052220.78278366
69Histidine metabolism_Homo sapiens_hsa003400.77919805
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.77772980
71mRNA surveillance pathway_Homo sapiens_hsa030150.77507765
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77309623
73Prion diseases_Homo sapiens_hsa050200.75460443
74Starch and sucrose metabolism_Homo sapiens_hsa005000.75296127
75Fructose and mannose metabolism_Homo sapiens_hsa000510.73669735
76Vitamin digestion and absorption_Homo sapiens_hsa049770.72950429
77Toxoplasmosis_Homo sapiens_hsa051450.72592512
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.72471409
79Amoebiasis_Homo sapiens_hsa051460.71834888
80Chronic myeloid leukemia_Homo sapiens_hsa052200.71393299
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.70026081
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69746555
83Colorectal cancer_Homo sapiens_hsa052100.69309735
84Hematopoietic cell lineage_Homo sapiens_hsa046400.69020821
85MAPK signaling pathway_Homo sapiens_hsa040100.68470607
86MicroRNAs in cancer_Homo sapiens_hsa052060.67360740
87Rap1 signaling pathway_Homo sapiens_hsa040150.66525815
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64857625
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64476135
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64340801
91Hepatitis C_Homo sapiens_hsa051600.64119567
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63606889
93Herpes simplex infection_Homo sapiens_hsa051680.63385035
94Renal cell carcinoma_Homo sapiens_hsa052110.62178178
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61845253
96TNF signaling pathway_Homo sapiens_hsa046680.61314046
97Lysosome_Homo sapiens_hsa041420.60566088
98Endocytosis_Homo sapiens_hsa041440.60428336
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60078468
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59676191
101Shigellosis_Homo sapiens_hsa051310.59445955
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.59359021
103Bladder cancer_Homo sapiens_hsa052190.59221627
104Glucagon signaling pathway_Homo sapiens_hsa049220.58484146
105Pertussis_Homo sapiens_hsa051330.58353478
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.58312164
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57358322
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.57196471
109mTOR signaling pathway_Homo sapiens_hsa041500.56925565
110Influenza A_Homo sapiens_hsa051640.56427916
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55435517
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55412584
113Basal cell carcinoma_Homo sapiens_hsa052170.54745070
114Retinol metabolism_Homo sapiens_hsa008300.54742670
115Proteoglycans in cancer_Homo sapiens_hsa052050.54520370
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54085410
117Ras signaling pathway_Homo sapiens_hsa040140.53708877
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.53182943
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53045984
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52860165
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52799134
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52287190
123Pancreatic cancer_Homo sapiens_hsa052120.51340824
124Platelet activation_Homo sapiens_hsa046110.50104836
125Insulin signaling pathway_Homo sapiens_hsa049100.49963185
126Focal adhesion_Homo sapiens_hsa045100.49807439
127Chemical carcinogenesis_Homo sapiens_hsa052040.49747973
128ECM-receptor interaction_Homo sapiens_hsa045120.49564564
129HIF-1 signaling pathway_Homo sapiens_hsa040660.49517532
130Melanogenesis_Homo sapiens_hsa049160.49249069
131Prostate cancer_Homo sapiens_hsa052150.48888071
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48488600
133Thyroid hormone synthesis_Homo sapiens_hsa049180.48323451
134Pathways in cancer_Homo sapiens_hsa052000.47733613
135FoxO signaling pathway_Homo sapiens_hsa040680.47704528
136Prolactin signaling pathway_Homo sapiens_hsa049170.46358753
137Pancreatic secretion_Homo sapiens_hsa049720.45545377
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45494375
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.43659507
140Leishmaniasis_Homo sapiens_hsa051400.43310399
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42860247
142Choline metabolism in cancer_Homo sapiens_hsa052310.41499866
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40899985
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39562395
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39307828
146Circadian rhythm_Homo sapiens_hsa047100.39297192
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39077388
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36823000
149Adherens junction_Homo sapiens_hsa045200.36819709
150Chemokine signaling pathway_Homo sapiens_hsa040620.36645133
151Hepatitis B_Homo sapiens_hsa051610.36562642
152Folate biosynthesis_Homo sapiens_hsa007900.36180496

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