CCNL2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)6.25005752
2opioid receptor signaling pathway (GO:0038003)5.14915067
3phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.76996401
4positive regulation of B cell differentiation (GO:0045579)4.68380542
5cellular extravasation (GO:0045123)4.37022065
6regulation of B cell receptor signaling pathway (GO:0050855)4.36463331
7interkinetic nuclear migration (GO:0022027)4.32811291
8regulation of germinal center formation (GO:0002634)4.18964141
9positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.99516979
10positive regulation of developmental pigmentation (GO:0048087)3.92939311
11cellular response to exogenous dsRNA (GO:0071360)3.92295130
12striated muscle atrophy (GO:0014891)3.90297971
13positive thymic T cell selection (GO:0045059)3.82220448
14nucleoside diphosphate catabolic process (GO:0009134)3.81864870
15snRNA transcription (GO:0009301)3.80481609
16muscle atrophy (GO:0014889)3.79968340
17microglial cell activation (GO:0001774)3.76319254
18skeletal muscle adaptation (GO:0043501)3.72027553
19positive regulation of gamma-delta T cell activation (GO:0046645)3.69722619
20neutrophil mediated immunity (GO:0002446)3.68918114
21positive T cell selection (GO:0043368)3.63012466
22alanine transport (GO:0032328)3.59459485
23protein K48-linked deubiquitination (GO:0071108)3.54978642
24negative thymic T cell selection (GO:0045060)3.54283309
25regulation of B cell differentiation (GO:0045577)3.52821850
26negative T cell selection (GO:0043383)3.45814661
27phosphorelay signal transduction system (GO:0000160)3.37436232
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37226329
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37226329
30histone H3-K9 methylation (GO:0051567)3.36905071
31reactive oxygen species biosynthetic process (GO:1903409)3.34078540
32hydrogen peroxide biosynthetic process (GO:0050665)3.33549509
33fucose catabolic process (GO:0019317)3.31079231
34L-fucose metabolic process (GO:0042354)3.31079231
35L-fucose catabolic process (GO:0042355)3.31079231
36monoubiquitinated protein deubiquitination (GO:0035520)3.27496495
37disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.24665595
38killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.24665595
39pyrimidine nucleotide catabolic process (GO:0006244)3.24408971
40valine metabolic process (GO:0006573)3.22746060
41cytoplasmic mRNA processing body assembly (GO:0033962)3.20300992
42histone-serine phosphorylation (GO:0035404)3.18856738
43histone H3-K9 modification (GO:0061647)3.18116372
44regulation of pigment cell differentiation (GO:0050932)3.17420909
45cellular ketone body metabolic process (GO:0046950)3.13361234
46DNA damage response, detection of DNA damage (GO:0042769)3.10377252
47myeloid leukocyte mediated immunity (GO:0002444)3.07687876
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06387317
49positive regulation of toll-like receptor signaling pathway (GO:0034123)3.04462639
50cerebellar Purkinje cell differentiation (GO:0021702)3.02873203
51cellular response to ethanol (GO:0071361)3.02572987
52rRNA catabolic process (GO:0016075)2.98413044
53regulation of MHC class II biosynthetic process (GO:0045346)2.97732306
54regulation of gamma-delta T cell differentiation (GO:0045586)2.95045226
55positive regulation of Rap GTPase activity (GO:0032854)2.94898643
56lysosome organization (GO:0007040)2.94724844
57lytic vacuole organization (GO:0080171)2.94724844
58regulation of interferon-gamma biosynthetic process (GO:0045072)2.93670002
59negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93501611
60indolalkylamine catabolic process (GO:0046218)2.93199463
61tryptophan catabolic process (GO:0006569)2.93199463
62indole-containing compound catabolic process (GO:0042436)2.93199463
63negative regulation of interleukin-8 production (GO:0032717)2.91056248
64regulation of interleukin-12 biosynthetic process (GO:0045075)2.90836491
65peptidyl-lysine methylation (GO:0018022)2.89362343
66negative regulation of sodium ion transport (GO:0010766)2.85508056
67cAMP catabolic process (GO:0006198)2.85338088
68positive regulation of B cell activation (GO:0050871)2.82150649
69DNA methylation involved in gamete generation (GO:0043046)2.81869247
70megakaryocyte development (GO:0035855)2.80299948
71organ growth (GO:0035265)2.76935544
72regulation of gene expression by genetic imprinting (GO:0006349)2.76035517
73positive regulation of B cell proliferation (GO:0030890)2.75347973
74positive regulation of DNA recombination (GO:0045911)2.75116763
75ketone body metabolic process (GO:1902224)2.74245894
76regulation of chemokine biosynthetic process (GO:0045073)2.74000079
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73006910
78C4-dicarboxylate transport (GO:0015740)2.72894849
79histone mRNA catabolic process (GO:0071044)2.72472034
80establishment of protein localization to Golgi (GO:0072600)2.68630183
81cyclic nucleotide catabolic process (GO:0009214)2.68236179
82respiratory burst (GO:0045730)2.67921860
83positive regulation of cytokine biosynthetic process (GO:0042108)2.67343725
84regulation of interferon-beta biosynthetic process (GO:0045357)2.66528094
85regulation of gamma-delta T cell activation (GO:0046643)2.66520634
86primary amino compound metabolic process (GO:1901160)2.63220259
87I-kappaB phosphorylation (GO:0007252)2.62897647
88protein targeting to lysosome (GO:0006622)2.62581492
89establishment of protein localization to vacuole (GO:0072666)2.62581492
90protein targeting to vacuole (GO:0006623)2.62581492
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62115963
92regulation of hippo signaling (GO:0035330)2.60918606
93B cell proliferation (GO:0042100)2.59452551
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59184623
95protein K63-linked deubiquitination (GO:0070536)2.58556806
96regulation of B cell apoptotic process (GO:0002902)2.57371300
97negative regulation of growth of symbiont in host (GO:0044130)2.56173965
98negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.56173965
99modulation of growth of symbiont involved in interaction with host (GO:0044144)2.56173965
100regulation of growth of symbiont in host (GO:0044126)2.56173965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.83847540
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.09325283
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.00644917
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.95446862
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88743159
6AR_21572438_ChIP-Seq_LNCaP_Human2.58036586
7GBX2_23144817_ChIP-Seq_PC3_Human2.55408047
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52915073
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41840201
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33313443
11IGF1R_20145208_ChIP-Seq_DFB_Human2.14128623
12SCL_19346495_ChIP-Seq_HPC-7_Human2.08840218
13VDR_22108803_ChIP-Seq_LS180_Human2.02164258
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95888745
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95615996
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88581616
17ZNF274_21170338_ChIP-Seq_K562_Hela1.87173791
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83532675
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81311895
20DROSHA_22980978_ChIP-Seq_HELA_Human1.77381160
21GATA1_22025678_ChIP-Seq_K562_Human1.77327706
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72153017
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.66425989
24ER_23166858_ChIP-Seq_MCF-7_Human1.64952489
25MYB_26560356_Chip-Seq_TH2_Human1.64282601
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63850927
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61003584
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60698898
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59848653
30TAF15_26573619_Chip-Seq_HEK293_Human1.59448689
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.59290576
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59144410
33RUNX_20019798_ChIP-Seq_JUKART_Human1.57613233
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.56970089
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55676744
36STAT3_23295773_ChIP-Seq_U87_Human1.48192561
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45627886
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.44007999
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.43924142
40TCF4_23295773_ChIP-Seq_U87_Human1.43480695
41FUS_26573619_Chip-Seq_HEK293_Human1.41507027
42TP53_16413492_ChIP-PET_HCT116_Human1.40287861
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40143976
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40143976
45GATA3_27048872_Chip-Seq_THYMUS_Human1.40105780
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39968789
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38156696
48GATA3_26560356_Chip-Seq_TH2_Human1.36927652
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35947992
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33366110
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.31388501
52EWS_26573619_Chip-Seq_HEK293_Human1.29662280
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.25947378
54P300_19829295_ChIP-Seq_ESCs_Human1.25602814
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21736474
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20344912
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19053168
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17465750
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15218806
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14891367
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.14172304
62MYB_26560356_Chip-Seq_TH1_Human1.13872776
63AR_25329375_ChIP-Seq_VCAP_Human1.11466583
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10277645
65BCAT_22108803_ChIP-Seq_LS180_Human1.09148295
66GATA3_26560356_Chip-Seq_TH1_Human1.07908940
67OCT1_27270436_Chip-Seq_PROSTATE_Human1.07815071
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07281332
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.07202619
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06600182
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06502958
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05961327
73TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04591944
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04063266
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02721108
76CBP_20019798_ChIP-Seq_JUKART_Human1.02721108
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.02636785
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01255680
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00905423
80PIAS1_25552417_ChIP-Seq_VCAP_Human0.99989981
81REST_21632747_ChIP-Seq_MESCs_Mouse0.99861157
82SOX2_21211035_ChIP-Seq_LN229_Gbm0.99391367
83AHR_22903824_ChIP-Seq_MCF-7_Human0.99162386
84FLI1_21867929_ChIP-Seq_TH2_Mouse0.97861328
85RXR_22108803_ChIP-Seq_LS180_Human0.97835760
86MYC_22102868_ChIP-Seq_BL_Human0.97734939
87OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93350771
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93187739
89RUNX2_22187159_ChIP-Seq_PCA_Human0.92932884
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.92259892
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92161535
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.91660795
93P53_22387025_ChIP-Seq_ESCs_Mouse0.90974551
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90895766
95SMRT_27268052_Chip-Seq_Bcells_Human0.90822654
96TCF4_22108803_ChIP-Seq_LS180_Human0.90705292
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.90703426
98CEBPB_22108803_ChIP-Seq_LS180_Human0.90595115
99KDM2B_26808549_Chip-Seq_REH_Human0.89893172
100SMAD4_21799915_ChIP-Seq_A2780_Human0.89814743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.67883476
2MP0003787_abnormal_imprinting3.59069216
3MP0008057_abnormal_DNA_replication3.56441408
4MP0008877_abnormal_DNA_methylation3.09708093
5MP0003172_abnormal_lysosome_physiology3.02774524
6MP0001800_abnormal_humoral_immune2.75207208
7MP0005075_abnormal_melanosome_morpholog2.67103341
8MP0003195_calcinosis2.63936684
9MP0008961_abnormal_basal_metabolism2.28288473
10MP0001790_abnormal_immune_system2.20681619
11MP0005387_immune_system_phenotype2.20681619
12MP0003763_abnormal_thymus_physiology2.08060413
13MP0005310_abnormal_salivary_gland2.00353605
14MP0002822_catalepsy1.99823462
15MP0005551_abnormal_eye_electrophysiolog1.98799187
16MP0005174_abnormal_tail_pigmentation1.98109728
17MP0005645_abnormal_hypothalamus_physiol1.97131698
18MP0002009_preneoplasia1.85637348
19MP0002452_abnormal_antigen_presenting1.79866574
20MP0003183_abnormal_peptide_metabolism1.76776395
21MP0002420_abnormal_adaptive_immunity1.76312957
22MP0003646_muscle_fatigue1.71659740
23MP0002723_abnormal_immune_serum1.68376494
24MP0001819_abnormal_immune_cell1.68081542
25MP0004036_abnormal_muscle_relaxation1.67076469
26MP0005671_abnormal_response_to1.65674060
27MP0001835_abnormal_antigen_presentation1.64356305
28MP0004145_abnormal_muscle_electrophysio1.62674301
29MP0005076_abnormal_cell_differentiation1.62156803
30MP0000689_abnormal_spleen_morphology1.50059785
31MP0004084_abnormal_cardiac_muscle1.47513936
32MP0005266_abnormal_metabolism1.44182255
33MP0004130_abnormal_muscle_cell1.41345021
34MP0002396_abnormal_hematopoietic_system1.35485683
35MP0009384_cardiac_valve_regurgitation1.33730794
36MP0005000_abnormal_immune_tolerance1.33708300
37MP0002398_abnormal_bone_marrow1.33105417
38MP0000015_abnormal_ear_pigmentation1.32830355
39MP0003123_paternal_imprinting1.30501251
40MP0006138_congestive_heart_failure1.29089197
41MP0000716_abnormal_immune_system1.28575128
42MP0003690_abnormal_glial_cell1.28332692
43MP0002332_abnormal_exercise_endurance1.28196214
44MP0003121_genomic_imprinting1.22535366
45MP0005167_abnormal_blood-brain_barrier1.21934612
46MP0003045_fibrosis1.21389893
47MP0005451_abnormal_body_composition1.20748192
48MP0000383_abnormal_hair_follicle1.16788726
49MP0000465_gastrointestinal_hemorrhage1.16443426
50MP0004381_abnormal_hair_follicle1.15804503
51MP0003303_peritoneal_inflammation1.14197336
52MP0001968_abnormal_touch/_nociception1.08942413
53MP0005535_abnormal_body_temperature1.06639927
54MP0003890_abnormal_embryonic-extraembry1.05730333
55MP0002229_neurodegeneration1.04489950
56MP0002419_abnormal_innate_immunity1.01826706
57MP0003950_abnormal_plasma_membrane1.01480671
58MP0005025_abnormal_response_to1.01015283
59MP0000372_irregular_coat_pigmentation0.99135509
60MP0006292_abnormal_olfactory_placode0.98382399
61MP0000462_abnormal_digestive_system0.98052011
62MP0009046_muscle_twitch0.97123310
63MP0001486_abnormal_startle_reflex0.95436248
64MP0002234_abnormal_pharynx_morphology0.92488052
65MP0002067_abnormal_sensory_capabilities0.90406262
66MP0008995_early_reproductive_senescence0.89389641
67MP0002429_abnormal_blood_cell0.88812578
68MP0002933_joint_inflammation0.88383165
69MP0002722_abnormal_immune_system0.87814864
70MP0002095_abnormal_skin_pigmentation0.87618896
71MP0003866_abnormal_defecation0.86398182
72MP0002928_abnormal_bile_duct0.85707190
73MP0002405_respiratory_system_inflammati0.84000293
74MP0002876_abnormal_thyroid_physiology0.83667856
75MP0002736_abnormal_nociception_after0.83541596
76MP0009745_abnormal_behavioral_response0.83404052
77MP0005448_abnormal_energy_balance0.82485046
78MP0008058_abnormal_DNA_repair0.80717184
79MP0009780_abnormal_chondrocyte_physiolo0.80226634
80MP0001845_abnormal_inflammatory_respons0.79720564
81MP0005253_abnormal_eye_physiology0.79396737
82MP0003283_abnormal_digestive_organ0.79331398
83MP0010386_abnormal_urinary_bladder0.75552719
84MP0002638_abnormal_pupillary_reflex0.75442682
85MP0001502_abnormal_circadian_rhythm0.75338917
86MP0001764_abnormal_homeostasis0.73659437
87MP0002693_abnormal_pancreas_physiology0.72572260
88MP0002078_abnormal_glucose_homeostasis0.70796930
89MP0002064_seizures0.70756233
90MP0000685_abnormal_immune_system0.70656731
91MP0001299_abnormal_eye_distance/0.69156056
92MP0004043_abnormal_pH_regulation0.68897652
93MP0002148_abnormal_hypersensitivity_rea0.68280425
94MP0001986_abnormal_taste_sensitivity0.67423283
95MP0004808_abnormal_hematopoietic_stem0.65953087
96MP0001929_abnormal_gametogenesis0.65654678
97MP0009785_altered_susceptibility_to0.65565058
98MP0005584_abnormal_enzyme/coenzyme_acti0.64898670
99MP0002272_abnormal_nervous_system0.62909352
100MP0008872_abnormal_physiological_respon0.62023367

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.67103358
2Congenital stationary night blindness (HP:0007642)4.79926276
3Absent/shortened dynein arms (HP:0200106)4.72688458
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.72688458
5Panhypogammaglobulinemia (HP:0003139)4.30104973
6Genetic anticipation (HP:0003743)4.23331407
7Protruding tongue (HP:0010808)4.03843823
8Chronic hepatic failure (HP:0100626)3.82138361
9Recurrent bacterial skin infections (HP:0005406)3.76370134
10Clumsiness (HP:0002312)3.60201635
11Recurrent bronchitis (HP:0002837)3.58482720
12Cellulitis (HP:0100658)3.57971197
13Pigmentary retinal degeneration (HP:0001146)3.53559190
14Fair hair (HP:0002286)3.40298012
15Meningitis (HP:0001287)3.30099212
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.29495810
17Hyperventilation (HP:0002883)3.28074179
18Recurrent pneumonia (HP:0006532)3.27459441
19Renal cortical cysts (HP:0000803)3.20387634
20Birth length less than 3rd percentile (HP:0003561)3.18558371
21Recurrent sinusitis (HP:0011108)3.11202073
22Nephronophthisis (HP:0000090)3.10554460
23Viral hepatitis (HP:0006562)3.02762175
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.96640278
25Recurrent abscess formation (HP:0002722)2.87174761
26Progressive cerebellar ataxia (HP:0002073)2.85043652
27Abnormality of the renal medulla (HP:0100957)2.76498540
28Eczematoid dermatitis (HP:0000976)2.75987047
29Osteomyelitis (HP:0002754)2.72380942
30Increased cerebral lipofuscin (HP:0011813)2.70496317
31Generalized hypopigmentation of hair (HP:0011358)2.68424807
32Chronic otitis media (HP:0000389)2.64032002
33Molar tooth sign on MRI (HP:0002419)2.63125132
34Abnormality of midbrain morphology (HP:0002418)2.63125132
35Agitation (HP:0000713)2.61770933
36Limb hypertonia (HP:0002509)2.58216008
37Abnormal respiratory epithelium morphology (HP:0012253)2.55264880
38Abnormal respiratory motile cilium morphology (HP:0005938)2.55264880
39Abnormality of the prostate (HP:0008775)2.51054180
40Chronic sinusitis (HP:0011109)2.50016169
41Pancreatic cysts (HP:0001737)2.45531366
42Infantile muscular hypotonia (HP:0008947)2.44853025
43Abnormality of the renal cortex (HP:0011035)2.44535623
44Broad face (HP:0000283)2.43330201
45Widely spaced teeth (HP:0000687)2.38801814
46Chorioretinal atrophy (HP:0000533)2.37985279
47Dialeptic seizures (HP:0011146)2.37798095
48Hemiplegia (HP:0002301)2.37143734
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.36979662
50Recurrent lower respiratory tract infections (HP:0002783)2.36316225
51Recurrent viral infections (HP:0004429)2.35020468
52Eosinophilia (HP:0001880)2.32418774
53Colitis (HP:0002583)2.31643603
54Truncal obesity (HP:0001956)2.31065181
55Papilloma (HP:0012740)2.27974159
56Verrucae (HP:0200043)2.27974159
57Recurrent fungal infections (HP:0002841)2.26568927
58Recurrent gram-negative bacterial infections (HP:0005420)2.25639115
59Mediastinal lymphadenopathy (HP:0100721)2.25361572
60Absence seizures (HP:0002121)2.24083240
61Pancreatic fibrosis (HP:0100732)2.22098946
62Posterior subcapsular cataract (HP:0007787)2.18921207
63Macular degeneration (HP:0000608)2.13935972
64Encephalitis (HP:0002383)2.12143005
65Sepsis (HP:0100806)2.08612991
66Inflammation of the large intestine (HP:0002037)2.06790386
67Gastrointestinal stroma tumor (HP:0100723)2.06120424
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.01555684
69Atonic seizures (HP:0010819)2.01167467
70Abnormality of eosinophils (HP:0001879)2.00436307
71Recurrent skin infections (HP:0001581)1.99207082
72Thoracolumbar scoliosis (HP:0002944)1.97004020
73Mucopolysacchariduria (HP:0008155)1.95083911
74Urinary glycosaminoglycan excretion (HP:0003541)1.95083911
75Gastrointestinal inflammation (HP:0004386)1.93770816
76True hermaphroditism (HP:0010459)1.92810343
77Cervical subluxation (HP:0003308)1.90159172
78Abnormal ciliary motility (HP:0012262)1.88907375
79Partial agenesis of the corpus callosum (HP:0001338)1.88590222
80Gaze-evoked nystagmus (HP:0000640)1.88426948
81Neurodegeneration (HP:0002180)1.87043042
82Calf muscle hypertrophy (HP:0008981)1.85234787
83IgA deficiency (HP:0002720)1.83764347
84Relative macrocephaly (HP:0004482)1.83712647
85Thrombocytosis (HP:0001894)1.82836972
86Stomach cancer (HP:0012126)1.82832967
87Flared iliac wings (HP:0002869)1.82189466
88Restrictive lung disease (HP:0002091)1.79700464
89Broad-based gait (HP:0002136)1.79678664
90Granulocytopenia (HP:0001913)1.77250721
91Hypoplastic labia majora (HP:0000059)1.76863077
92Obstructive lung disease (HP:0006536)1.72685679
93Chronic obstructive pulmonary disease (HP:0006510)1.72685679
94Bronchitis (HP:0012387)1.71791320
95Oligodactyly (hands) (HP:0001180)1.71209977
96Aplasia/hypoplasia of the uterus (HP:0008684)1.70073935
97Abnormality of the labia majora (HP:0012881)1.69596760
98Global brain atrophy (HP:0002283)1.67761348
99Hematochezia (HP:0002573)1.64780162
100Ulnar claw (HP:0001178)1.64458720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.23848584
2FRK3.18435075
3CAMKK23.06139551
4BMPR1B2.94208143
5TEC2.87782943
6BTK2.50024938
7ITK2.38329119
8IRAK42.24497251
9TLK12.07216532
10TNIK2.06482178
11TNK22.04297789
12INSRR1.88603747
13SYK1.82908545
14BMPR21.76752811
15CDK121.71935002
16NUAK11.70542000
17OBSCN1.64278149
18IRAK11.61255101
19BLK1.48997907
20MAPK131.42918869
21MAP3K21.42017996
22STK161.40973635
23NTRK31.35703184
24PBK1.28327053
25LYN1.28205415
26PKN11.27680645
27EIF2AK31.26490721
28PTK2B1.25382404
29BRSK21.24228733
30GRK61.23734371
31MAPKAPK31.21210116
32DAPK21.19870026
33ZAK1.18035789
34IKBKB1.18014674
35TGFBR11.17668078
36CCNB11.17649665
37TAOK31.15947342
38LCK1.14072291
39KIT1.12041129
40STK381.10210958
41CHUK1.04206883
42CDK31.00453531
43PIM11.00119735
44MARK20.99974453
45CAMK1D0.96448023
46MAP2K10.93426964
47RIPK40.90887113
48ZAP700.90431885
49CAMKK10.84921987
50MAPK110.83981613
51LATS10.83476892
52TYK20.81098709
53NTRK20.80881203
54MAP4K10.78203160
55ADRBK10.77035588
56WNK30.76719978
57PIK3CG0.75879218
58PRKCQ0.74927747
59ADRBK20.74843741
60MAPK120.73515218
61MAPK150.72609672
62PIK3CA0.71627948
63TXK0.70787816
64MAP3K130.69728932
65SIK20.69511526
66JAK10.67933587
67IKBKE0.65228116
68RPS6KB20.64796782
69HIPK20.61845773
70MAP3K40.60877489
71TRPM70.58874675
72FES0.58676523
73CAMK10.57951154
74PRKAA10.55046435
75PAK30.54375702
76MAP3K70.53525961
77MELK0.53276625
78SGK20.52989161
79PASK0.52840732
80FGFR20.51584794
81TIE10.51337490
82PRKAA20.51131158
83ICK0.51078593
84PHKG20.50569557
85PHKG10.50569557
86IRAK20.49746617
87JAK20.48577481
88JAK30.48140501
89CSNK1D0.45096439
90RPS6KA30.45084927
91AKT30.43596518
92HCK0.42746598
93RPS6KA50.42597969
94CASK0.41756277
95NEK90.41555830
96PRKCZ0.39858762
97SGK2230.38883353
98SGK4940.38883353
99DMPK0.38180735
100CAMK40.37722490

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.55153927
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.42068247
3Sulfur metabolism_Homo sapiens_hsa009203.31796341
4B cell receptor signaling pathway_Homo sapiens_hsa046623.12697987
5Allograft rejection_Homo sapiens_hsa053302.53782112
6Type I diabetes mellitus_Homo sapiens_hsa049402.47229530
7Graft-versus-host disease_Homo sapiens_hsa053322.45730811
8Autoimmune thyroid disease_Homo sapiens_hsa053202.44516456
9Asthma_Homo sapiens_hsa053102.32534729
10Phototransduction_Homo sapiens_hsa047442.25489466
11Non-homologous end-joining_Homo sapiens_hsa034502.12450697
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03006816
13Olfactory transduction_Homo sapiens_hsa047401.98004851
14Ether lipid metabolism_Homo sapiens_hsa005651.91193607
15Caffeine metabolism_Homo sapiens_hsa002321.89645468
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.67080189
17ABC transporters_Homo sapiens_hsa020101.64763080
18Linoleic acid metabolism_Homo sapiens_hsa005911.57523173
19Systemic lupus erythematosus_Homo sapiens_hsa053221.56409468
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46832608
21Leishmaniasis_Homo sapiens_hsa051401.43260429
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38726740
23Type II diabetes mellitus_Homo sapiens_hsa049301.35987460
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.33785154
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24086089
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24025749
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15320301
28Lysine degradation_Homo sapiens_hsa003101.13699260
29Hematopoietic cell lineage_Homo sapiens_hsa046401.12313214
30Taste transduction_Homo sapiens_hsa047421.08350680
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05581875
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05421251
33Osteoclast differentiation_Homo sapiens_hsa043801.03756937
34Staphylococcus aureus infection_Homo sapiens_hsa051501.02634389
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.01477071
36Rheumatoid arthritis_Homo sapiens_hsa053230.99074698
37Regulation of autophagy_Homo sapiens_hsa041400.95582397
38RNA polymerase_Homo sapiens_hsa030200.93094681
39Homologous recombination_Homo sapiens_hsa034400.92939002
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.91469316
41Tuberculosis_Homo sapiens_hsa051520.91187169
42Nicotine addiction_Homo sapiens_hsa050330.87339085
43Circadian rhythm_Homo sapiens_hsa047100.87329358
44Morphine addiction_Homo sapiens_hsa050320.86794765
45Inositol phosphate metabolism_Homo sapiens_hsa005620.85200644
46Antigen processing and presentation_Homo sapiens_hsa046120.84371389
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83017413
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.82306086
49Toxoplasmosis_Homo sapiens_hsa051450.78745405
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78348368
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77781164
52Fatty acid biosynthesis_Homo sapiens_hsa000610.76875007
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76750129
54FoxO signaling pathway_Homo sapiens_hsa040680.76578846
55Butanoate metabolism_Homo sapiens_hsa006500.76104322
56Ovarian steroidogenesis_Homo sapiens_hsa049130.73696984
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.73002057
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71230342
59Calcium signaling pathway_Homo sapiens_hsa040200.67533470
60Purine metabolism_Homo sapiens_hsa002300.64955349
61T cell receptor signaling pathway_Homo sapiens_hsa046600.64054316
62RNA degradation_Homo sapiens_hsa030180.63342667
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62169615
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61545361
65Platelet activation_Homo sapiens_hsa046110.60450401
66Glutamatergic synapse_Homo sapiens_hsa047240.59766206
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58239379
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56871069
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56865292
70Viral myocarditis_Homo sapiens_hsa054160.55962799
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.54725060
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53983747
73Dorso-ventral axis formation_Homo sapiens_hsa043200.53890320
74Epstein-Barr virus infection_Homo sapiens_hsa051690.53564811
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53537140
76Measles_Homo sapiens_hsa051620.52322916
77mTOR signaling pathway_Homo sapiens_hsa041500.50596795
78Chemokine signaling pathway_Homo sapiens_hsa040620.47532771
79Salivary secretion_Homo sapiens_hsa049700.46254478
80Insulin secretion_Homo sapiens_hsa049110.44745756
81Arachidonic acid metabolism_Homo sapiens_hsa005900.44669636
82Viral carcinogenesis_Homo sapiens_hsa052030.44451575
83Herpes simplex infection_Homo sapiens_hsa051680.41476417
84Pancreatic secretion_Homo sapiens_hsa049720.41066245
85TNF signaling pathway_Homo sapiens_hsa046680.41016598
86One carbon pool by folate_Homo sapiens_hsa006700.40911484
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39941957
88Serotonergic synapse_Homo sapiens_hsa047260.39365631
89Cholinergic synapse_Homo sapiens_hsa047250.38701559
90Acute myeloid leukemia_Homo sapiens_hsa052210.38456778
91Small cell lung cancer_Homo sapiens_hsa052220.38086575
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37432559
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37061893
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.36088326
95Insulin resistance_Homo sapiens_hsa049310.36052561
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35774678
97Prolactin signaling pathway_Homo sapiens_hsa049170.35460447
98Nitrogen metabolism_Homo sapiens_hsa009100.34032045
99Long-term depression_Homo sapiens_hsa047300.29833829
100Influenza A_Homo sapiens_hsa051640.29497480

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