CCNO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)7.50242872
2histone H2A ubiquitination (GO:0033522)7.06289734
3left/right pattern formation (GO:0060972)6.81522058
4regulation of acrosome reaction (GO:0060046)6.70644394
5citrulline biosynthetic process (GO:0019240)6.66756261
6regulation of meiosis (GO:0040020)6.66482895
7female gamete generation (GO:0007292)6.66310555
8histone H2A monoubiquitination (GO:0035518)6.64625488
9protein K6-linked ubiquitination (GO:0085020)6.64385940
10mitotic chromosome condensation (GO:0007076)6.56444734
11negative regulation of smooth muscle cell differentiation (GO:0051151)6.45882205
12microtubule depolymerization (GO:0007019)6.43330370
13mitotic metaphase plate congression (GO:0007080)6.34706469
14DNA methylation involved in gamete generation (GO:0043046)6.31438736
15regulation of exit from mitosis (GO:0007096)6.17796078
16endothelium development (GO:0003158)6.00845043
17regulation of cilium movement (GO:0003352)5.93657143
18notochord development (GO:0030903)5.92124492
19negative regulation of meiosis (GO:0045835)5.74150049
20intraciliary transport (GO:0042073)5.65916916
21negative regulation of meiotic cell cycle (GO:0051447)5.53282499
22oocyte development (GO:0048599)5.35340726
23regulation of sister chromatid cohesion (GO:0007063)5.32374712
24multicellular organism reproduction (GO:0032504)5.28279112
25regulation of meiotic cell cycle (GO:0051445)5.24764737
26oocyte maturation (GO:0001556)5.23151680
27gene silencing by RNA (GO:0031047)5.17598454
28microtubule severing (GO:0051013)5.15454804
29regulation of DNA endoreduplication (GO:0032875)5.15294756
30metaphase plate congression (GO:0051310)5.07698932
31ventricular system development (GO:0021591)5.05942473
32negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.05402092
33protein localization to kinetochore (GO:0034501)4.97895732
34chaperone-mediated protein transport (GO:0072321)4.97178916
35meiotic cell cycle (GO:0051321)4.83989209
36microtubule bundle formation (GO:0001578)4.81170272
37establishment of chromosome localization (GO:0051303)4.80798049
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.79065690
39negative regulation of DNA-templated transcription, elongation (GO:0032785)4.79065690
40negative regulation of reproductive process (GO:2000242)4.76678728
41* cilium organization (GO:0044782)4.70529350
42* cilium assembly (GO:0042384)4.66902223
43male meiosis (GO:0007140)4.64508315
44regulation of hypersensitivity (GO:0002883)4.59646628
45hepatocyte differentiation (GO:0070365)4.55095240
46attachment of spindle microtubules to kinetochore (GO:0008608)4.51522487
47microtubule polymerization or depolymerization (GO:0031109)4.44791570
48left/right axis specification (GO:0070986)4.43070676
49regulation of microtubule-based movement (GO:0060632)4.41391830
50protein localization to chromosome, centromeric region (GO:0071459)4.38470201
51centriole replication (GO:0007099)4.36360233
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.27122763
53regulation of DNA methylation (GO:0044030)4.09535113
54response to pheromone (GO:0019236)4.09157341
55reproduction (GO:0000003)4.08870508
56microtubule-based movement (GO:0007018)4.04420345
57DNA alkylation (GO:0006305)4.04144253
58DNA methylation (GO:0006306)4.04144253
59primary alcohol catabolic process (GO:0034310)4.02431980
60diterpenoid biosynthetic process (GO:0016102)4.01696397
61oogenesis (GO:0048477)4.00261655
62mitotic sister chromatid cohesion (GO:0007064)3.99377770
63positive regulation of DNA-dependent DNA replication (GO:2000105)3.94824438
64regulation of retinoic acid receptor signaling pathway (GO:0048385)3.92011364
65mitotic sister chromatid segregation (GO:0000070)3.91841094
66protein deneddylation (GO:0000338)3.91696790
67citrulline metabolic process (GO:0000052)3.91406911
68ovulation cycle (GO:0042698)3.91341855
69regulation of phospholipid biosynthetic process (GO:0071071)3.89068807
70protein localization to chromosome (GO:0034502)3.84006860
71synaptonemal complex assembly (GO:0007130)3.83148189
72regulation of spindle organization (GO:0090224)3.80175901
73peptidyl-arginine modification (GO:0018195)3.79184874
74positive regulation of meiosis (GO:0045836)3.78826687
75establishment of apical/basal cell polarity (GO:0035089)3.78586070
76DNA damage induced protein phosphorylation (GO:0006975)3.76215405
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.74830655
78positive regulation of humoral immune response (GO:0002922)3.74674840
79nucleoside diphosphate phosphorylation (GO:0006165)3.67802947
80male meiosis I (GO:0007141)3.67538377
81regulation of histone H3-K27 methylation (GO:0061085)3.66905308
82fertilization (GO:0009566)3.66410836
83sperm capacitation (GO:0048240)3.65863604
84positive regulation of meiotic cell cycle (GO:0051446)3.62889916
85protein polyglutamylation (GO:0018095)3.62581554
86establishment of monopolar cell polarity (GO:0061162)3.59657123
87establishment or maintenance of monopolar cell polarity (GO:0061339)3.59657123
88lung epithelium development (GO:0060428)3.54759031
89* cellular component assembly involved in morphogenesis (GO:0010927)3.48661591
90pyrimidine-containing compound transmembrane transport (GO:0072531)3.48124140
91regulation of mitotic spindle organization (GO:0060236)3.47994308
92vitamin transmembrane transport (GO:0035461)3.44653270
93positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.44487917
94negative regulation of T cell differentiation in thymus (GO:0033085)3.39924099
95trophoblast giant cell differentiation (GO:0060707)3.39810079
96protein complex localization (GO:0031503)3.39717238
97positive regulation of Cdc42 GTPase activity (GO:0043089)3.39103278
98positive regulation of T cell apoptotic process (GO:0070234)3.38471292
99forebrain neuron development (GO:0021884)3.36981746
100positive regulation of chromosome segregation (GO:0051984)3.36164359
101chromosome organization involved in meiosis (GO:0070192)3.35277544
102CENP-A containing nucleosome assembly (GO:0034080)3.34615349
103immunoglobulin mediated immune response (GO:0016064)3.33835616
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.33766315
105synaptonemal complex organization (GO:0070193)3.33077394
106centriole assembly (GO:0098534)3.31649136
107regulation of chromosome segregation (GO:0051983)3.31047327
108single fertilization (GO:0007338)3.29168532
109histone exchange (GO:0043486)3.28059568
110* cell projection assembly (GO:0030031)3.27604573
111protein kinase C signaling (GO:0070528)3.26727648
112histone monoubiquitination (GO:0010390)3.26564581
113histone ubiquitination (GO:0016574)3.25999653
114cytoplasmic microtubule organization (GO:0031122)3.25590733
115chromosome segregation (GO:0007059)3.23499315
116regulation of RIG-I signaling pathway (GO:0039535)3.21125398
117regulation of steroid hormone secretion (GO:2000831)3.19141016
118sister chromatid segregation (GO:0000819)3.18857563
119chromatin remodeling at centromere (GO:0031055)3.18733338
120gene silencing (GO:0016458)3.16464246
121regulation of reproductive process (GO:2000241)3.12955560
122spindle checkpoint (GO:0031577)3.09627870
123fat-soluble vitamin biosynthetic process (GO:0042362)3.09406001
124meiosis I (GO:0007127)3.08140583
125protein localization to cilium (GO:0061512)3.07990607
126cilium morphogenesis (GO:0060271)3.07192868
127embryonic camera-type eye development (GO:0031076)3.06440308
128regulation of meiosis I (GO:0060631)3.03511236
129ovarian follicle development (GO:0001541)3.01623117
130meiotic chromosome segregation (GO:0045132)3.01560772
131regulation of smooth muscle cell differentiation (GO:0051150)3.00784799
132response to misfolded protein (GO:0051788)3.00658438
133sister chromatid cohesion (GO:0007062)3.00653447
134negative regulation of cell division (GO:0051782)2.99088074
135establishment of spindle localization (GO:0051293)2.98491736
136positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97161929
137positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97161929
138positive regulation of mitotic sister chromatid separation (GO:1901970)2.97161929
139regulation of cytokinesis (GO:0032465)2.92949480
140GTP biosynthetic process (GO:0006183)2.88291050
141synapsis (GO:0007129)2.82953797
142UTP biosynthetic process (GO:0006228)2.82915068
143protein depolymerization (GO:0051261)2.81667387
144sperm motility (GO:0030317)2.80255636
145microtubule-based process (GO:0007017)2.75064232
146ethanol metabolic process (GO:0006067)2.73435221
147meiotic nuclear division (GO:0007126)2.70913065
148phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.65027083
149terpenoid biosynthetic process (GO:0016114)2.63460442
150chaperone-mediated protein complex assembly (GO:0051131)2.61840961
151one-carbon compound transport (GO:0019755)2.58186316
152glomerular epithelial cell development (GO:0072310)2.55207257
153embryonic body morphogenesis (GO:0010172)2.54325849
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.53122921
155binding of sperm to zona pellucida (GO:0007339)2.52164173
156UTP metabolic process (GO:0046051)2.48949015
157dorsal/ventral neural tube patterning (GO:0021904)2.47650943
158establishment of tissue polarity (GO:0007164)2.46987046
159establishment of planar polarity (GO:0001736)2.46987046
160smoothened signaling pathway (GO:0007224)2.46938415
161response to xenobiotic stimulus (GO:0009410)2.44599280
162substrate-independent telencephalic tangential migration (GO:0021826)2.44179459
163substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.44179459
164negative regulation of inclusion body assembly (GO:0090084)2.41435911
165protein insertion into membrane (GO:0051205)2.39927335
166spermatid development (GO:0007286)2.39270897
167regulation of microtubule depolymerization (GO:0031114)2.38718167
168* organelle assembly (GO:0070925)2.38394405
169determination of left/right symmetry (GO:0007368)2.37063897
170specification of symmetry (GO:0009799)2.34644199
171histone H2A acetylation (GO:0043968)2.34154650
172myoblast migration (GO:0051451)2.33848083
173determination of bilateral symmetry (GO:0009855)2.33154158
174amino-acid betaine metabolic process (GO:0006577)2.32440886
175establishment or maintenance of bipolar cell polarity (GO:0061245)2.32309746
176establishment or maintenance of apical/basal cell polarity (GO:0035088)2.32309746
177mitochondrion degradation (GO:0000422)2.32195429
178COPI coating of Golgi vesicle (GO:0048205)2.31776937
179Golgi transport vesicle coating (GO:0048200)2.31776937
180meiotic cell cycle process (GO:1903046)2.28945633
181positive regulation of smoothened signaling pathway (GO:0045880)2.28864112
182axonemal dynein complex assembly (GO:0070286)17.4029318
183motile cilium assembly (GO:0044458)13.7796646
184cilium or flagellum-dependent cell motility (GO:0001539)12.9377828
185cilium movement (GO:0003341)12.0003115
186regulation of female gonad development (GO:2000194)11.9706249
187piRNA metabolic process (GO:0034587)11.9504830
188epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.6698098
189epithelial cilium movement (GO:0003351)11.4643625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.09622820
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.47553020
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.93842749
4E2F7_22180533_ChIP-Seq_HELA_Human4.71849645
5SALL1_21062744_ChIP-ChIP_HESCs_Human4.13455497
6AR_21909140_ChIP-Seq_LNCAP_Human3.68980761
7ZNF263_19887448_ChIP-Seq_K562_Human3.19206837
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.12467207
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.11641183
10KAP1_22055183_ChIP-Seq_ESCs_Mouse3.02830995
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.67116777
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42772217
13MYC_18940864_ChIP-ChIP_HL60_Human2.42668230
14P68_20966046_ChIP-Seq_HELA_Human2.34399378
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32320574
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.23172825
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20679841
18SMC4_20622854_ChIP-Seq_HELA_Human2.16597829
19* SIN3A_21632747_ChIP-Seq_MESCs_Mouse2.11503739
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.06248240
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.02497622
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.88074267
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.83497681
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.82582809
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80142976
26PHF8_20622854_ChIP-Seq_HELA_Human1.74602043
27RACK7_27058665_Chip-Seq_MCF-7_Human1.74313969
28YY1_22570637_ChIP-Seq_MALME-3M_Human1.71848631
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70769283
30NANOG_21062744_ChIP-ChIP_HESCs_Human1.67614786
31* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.65430971
32RNF2_27304074_Chip-Seq_NSC_Mouse1.63936229
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.63636302
34LXR_22292898_ChIP-Seq_THP-1_Human1.62794563
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61261055
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59542208
37XRN2_22483619_ChIP-Seq_HELA_Human1.59421207
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56770125
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55351268
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.55174195
41SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54717296
42RUNX1_26923725_Chip-Seq_HPCs_Mouse1.54114885
43CTCF_20526341_ChIP-Seq_ESCs_Human1.52855922
44DCP1A_22483619_ChIP-Seq_HELA_Human1.50863702
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48352098
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.47689399
47BCOR_27268052_Chip-Seq_Bcells_Human1.44910573
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42553451
49E2F1_20622854_ChIP-Seq_HELA_Human1.41934191
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41701080
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41601479
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.41152576
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40846206
54NFYA_21822215_ChIP-Seq_K562_Human1.40427716
55TP63_22573176_ChIP-Seq_HFKS_Human1.38314086
56BCL6_27268052_Chip-Seq_Bcells_Human1.37979346
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36079749
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34822886
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34704495
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34212487
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34190650
62* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34184954
63CREB1_26743006_Chip-Seq_LNCaP_Human1.32333143
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.31943067
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.30744026
66RARA_24833708_ChIP-Seq_LIVER_Mouse1.30446954
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29591139
68CTCF_27219007_Chip-Seq_Bcells_Human1.29479293
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.28113780
70GABP_19822575_ChIP-Seq_HepG2_Human1.27854369
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27495631
72RBPJ_21746931_ChIP-Seq_IB4_Human1.25106684
73FLI1_21867929_ChIP-Seq_CD8_Mouse1.24595877
74* GATA3_21867929_ChIP-Seq_TH1_Mouse1.23706581
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23618421
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22735219
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22283743
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.21648843
79ETV1_20927104_ChIP-Seq_GIST48_Human1.20663755
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19745474
81STAT1_17558387_ChIP-Seq_HELA_Human1.19595075
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18835588
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.17163230
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17051461
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16905242
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16550186
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15383773
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.13696954
89ATF3_27146783_Chip-Seq_COLON_Human1.13184415
90CDX2_22108803_ChIP-Seq_LS180_Human1.12157323
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.12112841
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12015983
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11702361
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11064084
95VDR_21846776_ChIP-Seq_THP-1_Human1.10838149
96* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10595908
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10492849
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09879371
99ESET_19884257_ChIP-Seq_ESCs_Mouse1.09126236
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08909821
101P300_27268052_Chip-Seq_Bcells_Human1.08444638
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08049268
103GATA6_21074721_ChIP-Seq_CACO-2_Human1.07713532
104PHF8_20622853_ChIP-Seq_HELA_Human1.06926908
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06787274
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.05453409
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05178828
108RARB_24833708_ChIP-Seq_LIVER_Mouse1.05158176
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04772169
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04477986
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04320663
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03900909
113ESR1_21235772_ChIP-Seq_MCF-7_Human1.03827652
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03665478
115TP53_22127205_ChIP-Seq_IMR90_Human1.03479526
116RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03195131
117CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02077927
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01890255
119* TTF2_22483619_ChIP-Seq_HELA_Human1.01775832
120STAT1_20625510_ChIP-Seq_HELA_Human1.01676705
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01094751
122CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00819694
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.00510459
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00420729
125KLF5_25053715_ChIP-Seq_YYC3_Human1.00410753
126ETS1_20019798_ChIP-Seq_JURKAT_Human0.99490682
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98773082
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98235979
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98095307
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98056791
131TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97997539
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97727998
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97502908
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96664602
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95845856
136DROSHA_22980978_ChIP-Seq_HELA_Human0.95627406
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95562940
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95514548
139KAP1_27257070_Chip-Seq_ESCs_Mouse0.95268395
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94999016
141MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94985587
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94454877
143ERA_21632823_ChIP-Seq_H3396_Human0.94050009
144ERG_20517297_ChIP-Seq_VCAP_Human0.93929792
145SOX2_21211035_ChIP-Seq_LN229_Human0.92851603
146SMRT_27268052_Chip-Seq_Bcells_Human0.92045066
147THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91898292
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91804906
149ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91528228
150TBL1_22424771_ChIP-Seq_293T_Human0.91169734
151ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91015473
152AR_21572438_ChIP-Seq_LNCaP_Human0.89967349
153NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89553497
154* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89168254
155FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89060374
156PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86856304
157TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86325793
158FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86004293
159GATA3_27048872_Chip-Seq_THYMUS_Human0.85566438
160PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83670663
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82507692
162* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82309397
163ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82120544
164NANOG_20526341_ChIP-Seq_ESCs_Human0.81793456
165GABP_17652178_ChIP-ChIP_JURKAT_Human0.81557095
166TP63_19390658_ChIP-ChIP_HaCaT_Human0.81533339
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81479303
168GATA3_26560356_Chip-Seq_TH1_Human0.80791325
169GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80763997
170NFYB_21822215_ChIP-Seq_K562_Human0.79615020
171OCT4_19829295_ChIP-Seq_ESCs_Human0.79066017
172TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78957552
173GF1B_26923725_Chip-Seq_HPCs_Mouse0.78866929
174FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.77763082
175FOXH1_21741376_ChIP-Seq_EPCs_Human0.77373048
176SPI1_26923725_Chip-Seq_HPCs_Mouse0.77335848
177RBPJ_22232070_ChIP-Seq_NCS_Mouse0.75490489
178OCT4_20526341_ChIP-Seq_ESCs_Human0.75391946
179NANOG_18692474_ChIP-Seq_MESCs_Mouse0.74986016
180KDM5A_27292631_Chip-Seq_BREAST_Human0.74330785
181* TET1_21490601_ChIP-Seq_MESCs_Mouse0.73183367
182FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72850826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.57287001
2MP0003646_muscle_fatigue6.23323257
3MP0008789_abnormal_olfactory_epithelium4.00846810
4MP0003693_abnormal_embryo_hatching3.89780429
5MP0008877_abnormal_DNA_methylation3.86415554
6MP0008875_abnormal_xenobiotic_pharmacok3.43072019
7MP0003699_abnormal_female_reproductive3.30824070
8MP0005395_other_phenotype3.30033663
9MP0001119_abnormal_female_reproductive3.26400104
10MP0010094_abnormal_chromosome_stability3.13463088
11MP0005394_taste/olfaction_phenotype3.09305179
12MP0005499_abnormal_olfactory_system3.09305179
13MP0000566_synostosis3.09125949
14MP0006292_abnormal_olfactory_placode3.08518480
15MP0005451_abnormal_body_composition2.84204993
16MP0001929_abnormal_gametogenesis2.82919088
17MP0002295_abnormal_pulmonary_circulatio2.70259000
18MP0004957_abnormal_blastocyst_morpholog2.66807314
19MP0003111_abnormal_nucleus_morphology2.63493776
20MP0004133_heterotaxia2.60724091
21MP0003077_abnormal_cell_cycle2.59540607
22MP0005623_abnormal_meninges_morphology2.53922389
23MP0000653_abnormal_sex_gland2.50668486
24MP0005083_abnormal_biliary_tract2.29914618
25MP0002210_abnormal_sex_determination2.29319683
26MP0009379_abnormal_foot_pigmentation2.25196033
27MP0005646_abnormal_pituitary_gland2.24205029
28MP0003315_abnormal_perineum_morphology2.22931728
29MP0000579_abnormal_nail_morphology2.17520610
30MP0002653_abnormal_ependyma_morphology2.16985661
31MP0000465_gastrointestinal_hemorrhage2.12662314
32MP0005409_darkened_coat_color2.06109339
33MP0008260_abnormal_autophagy2.05376832
34MP0000383_abnormal_hair_follicle2.05043372
35MP0010678_abnormal_skin_adnexa2.01660315
36MP0005187_abnormal_penis_morphology1.94937925
37MP0005257_abnormal_intraocular_pressure1.87349099
38MP0002161_abnormal_fertility/fecundity1.78609099
39MP0008932_abnormal_embryonic_tissue1.73004244
40MP0003787_abnormal_imprinting1.71788230
41MP0002796_impaired_skin_barrier1.69358862
42MP0004043_abnormal_pH_regulation1.67979620
43MP0002132_abnormal_respiratory_system1.67674599
44MP0002234_abnormal_pharynx_morphology1.67662812
45MP0001984_abnormal_olfaction1.67416040
46MP0003950_abnormal_plasma_membrane1.57961741
47MP0001145_abnormal_male_reproductive1.55617234
48MP0004019_abnormal_vitamin_homeostasis1.55078031
49MP0004782_abnormal_surfactant_physiolog1.52365846
50MP0002249_abnormal_larynx_morphology1.51527009
51MP0003121_genomic_imprinting1.50505648
52MP0003937_abnormal_limbs/digits/tail_de1.45573077
53MP0001529_abnormal_vocalization1.44311746
54MP0005501_abnormal_skin_physiology1.42789624
55MP0009780_abnormal_chondrocyte_physiolo1.38196580
56MP0000350_abnormal_cell_proliferation1.36127122
57MP0002233_abnormal_nose_morphology1.34321481
58MP0003123_paternal_imprinting1.33952762
59MP0000537_abnormal_urethra_morphology1.32930242
60MP0001730_embryonic_growth_arrest1.29846194
61MP0002932_abnormal_joint_morphology1.27588828
62MP0005360_urolithiasis1.23746654
63MP0004859_abnormal_synaptic_plasticity1.22658672
64MP0003183_abnormal_peptide_metabolism1.22134943
65MP0001905_abnormal_dopamine_level1.21084986
66MP0002085_abnormal_embryonic_tissue1.18008385
67MP0003453_abnormal_keratinocyte_physiol1.17619257
68MP0002102_abnormal_ear_morphology1.16606391
69MP0009840_abnormal_foam_cell1.16159699
70MP0002282_abnormal_trachea_morphology1.15791601
71MP0000762_abnormal_tongue_morphology1.14043981
72MP0002277_abnormal_respiratory_mucosa1.13551996
73MP0004233_abnormal_muscle_weight1.10615096
74MP0009384_cardiac_valve_regurgitation1.10035585
75MP0001188_hyperpigmentation1.06870531
76MP0001502_abnormal_circadian_rhythm1.06800340
77MP0005310_abnormal_salivary_gland1.03460279
78MP0010386_abnormal_urinary_bladder1.02949322
79MP0000049_abnormal_middle_ear1.01924417
80MP0000681_abnormal_thyroid_gland0.99741322
81MP0002098_abnormal_vibrissa_morphology0.99598621
82MP0001915_intracranial_hemorrhage0.98433754
83MP0000490_abnormal_crypts_of0.97947851
84MP0002019_abnormal_tumor_incidence0.96420828
85MP0004185_abnormal_adipocyte_glucose0.96109431
86MP0005389_reproductive_system_phenotype0.95812237
87MP0001672_abnormal_embryogenesis/_devel0.94559372
88MP0005380_embryogenesis_phenotype0.94559372
89MP0003890_abnormal_embryonic-extraembry0.94328733
90MP0001765_abnormal_ion_homeostasis0.92943786
91MP0003879_abnormal_hair_cell0.92130924
92MP0000358_abnormal_cell_content/0.88369919
93MP0008995_early_reproductive_senescence0.87821450
94MP0003806_abnormal_nucleotide_metabolis0.87624756
95MP0000613_abnormal_salivary_gland0.87442182
96MP0003763_abnormal_thymus_physiology0.87340917
97MP0001919_abnormal_reproductive_system0.86887706
98MP0003786_premature_aging0.86773898
99MP0006072_abnormal_retinal_apoptosis0.86009370
100MP0002909_abnormal_adrenal_gland0.84101859
101MP0003705_abnormal_hypodermis_morpholog0.83175621
102MP0000467_abnormal_esophagus_morphology0.81874578
103MP0005197_abnormal_uvea_morphology0.81341369
104MP0002084_abnormal_developmental_patter0.79583128
105MP0001697_abnormal_embryo_size0.79518175
106MP0005408_hypopigmentation0.78946037
107MP0002734_abnormal_mechanical_nocicepti0.78864099
108MP0005220_abnormal_exocrine_pancreas0.76770798
109MP0002332_abnormal_exercise_endurance0.74586380
110MP0002089_abnormal_postnatal_growth/wei0.73901991
111MP0003698_abnormal_male_reproductive0.73745933
112MP0004264_abnormal_extraembryonic_tissu0.73718867
113MP0003938_abnormal_ear_development0.72206820
114MP0001293_anophthalmia0.71153168
115MP0002168_other_aberrant_phenotype0.71061493
116MP0006036_abnormal_mitochondrial_physio0.70628101
117MP0001346_abnormal_lacrimal_gland0.68533026
118MP0003656_abnormal_erythrocyte_physiolo0.68472402
119MP0010771_integument_phenotype0.67984157
120MP0005621_abnormal_cell_physiology0.66958607
121MP0003755_abnormal_palate_morphology0.66085381
122MP0009053_abnormal_anal_canal0.65650779
123MP0003942_abnormal_urinary_system0.65307033
124MP0003936_abnormal_reproductive_system0.62787236
125MP0010368_abnormal_lymphatic_system0.62354171
126MP0001664_abnormal_digestion0.61921542
127MP0002080_prenatal_lethality0.61764682
128MP0003943_abnormal_hepatobiliary_system0.61015676
129MP0001727_abnormal_embryo_implantation0.60982375
130MP0001944_abnormal_pancreas_morphology0.60799824
131MP0000678_abnormal_parathyroid_gland0.60545718
132MP0000631_abnormal_neuroendocrine_gland0.60376672
133MP0000639_abnormal_adrenal_gland0.59278387
134MP0002127_abnormal_cardiovascular_syste0.58835202
135MP0008058_abnormal_DNA_repair0.57963246
136MP0010030_abnormal_orbit_morphology0.56706338
137MP0002160_abnormal_reproductive_system0.53063944
138MP0004510_myositis0.52876514
139MP0005023_abnormal_wound_healing0.51976664
140MP0001851_eye_inflammation0.51353205
141MP0000427_abnormal_hair_cycle0.50441443
142MP0010234_abnormal_vibrissa_follicle0.49572308
143MP0005384_cellular_phenotype0.47063202
144MP0002116_abnormal_craniofacial_bone0.45852108
145MP0004484_altered_response_of0.45733794
146MP0002269_muscular_atrophy0.45460415
147MP0003984_embryonic_growth_retardation0.45174467
148MP0008007_abnormal_cellular_replicative0.43426349
149MP0002088_abnormal_embryonic_growth/wei0.42900437
150MP0005193_abnormal_anterior_eye0.42067814
151MP0003861_abnormal_nervous_system0.41892966
152MP0001849_ear_inflammation0.41380196
153MP0000313_abnormal_cell_death0.39635138
154MP0002177_abnormal_outer_ear0.39421511
155MP0003935_abnormal_craniofacial_develop0.37532241

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.80989421
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.62308519
3Absent/shortened dynein arms (HP:0200106)9.62308519
4Premature ovarian failure (HP:0008209)8.35634172
5Male infertility (HP:0003251)7.83740649
6Cortical dysplasia (HP:0002539)7.48602461
7Nasal polyposis (HP:0100582)6.43187658
8* Bronchiectasis (HP:0002110)6.35950512
9Breast hypoplasia (HP:0003187)5.52727206
10Abnormality of the nasal mucosa (HP:0000433)5.19546634
11Birth length less than 3rd percentile (HP:0003561)5.12203222
12Deep venous thrombosis (HP:0002625)4.60352160
13Secondary amenorrhea (HP:0000869)4.40181704
14Flat capital femoral epiphysis (HP:0003370)4.35569247
15Patellar aplasia (HP:0006443)3.95943031
16Abnormality of the labia minora (HP:0012880)3.83706820
17* Infertility (HP:0000789)3.76954329
18Shawl scrotum (HP:0000049)3.72583406
19Aplasia/Hypoplasia of the breasts (HP:0010311)3.68846644
20Aplasia/Hypoplasia of the patella (HP:0006498)3.64596808
21Breast aplasia (HP:0100783)3.58401703
22Chronic sinusitis (HP:0011109)3.50431188
23Bronchitis (HP:0012387)3.43670666
24Recurrent otitis media (HP:0000403)3.38583886
25Pulmonary fibrosis (HP:0002206)3.30816402
26Anosmia (HP:0000458)3.29185661
27Abnormality of midbrain morphology (HP:0002418)3.22342974
28Molar tooth sign on MRI (HP:0002419)3.22342974
29Rhabdomyosarcoma (HP:0002859)3.20562162
30Pancreatic fibrosis (HP:0100732)3.16897217
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14836487
32Abnormality of the fovea (HP:0000493)3.13566460
33Abnormality of cochlea (HP:0000375)3.08176257
34Carpal bone hypoplasia (HP:0001498)3.07074326
35True hermaphroditism (HP:0010459)3.06448726
36Insulin-resistant diabetes mellitus (HP:0000831)3.04269012
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.01097656
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.96723195
39Hypoplasia of the fovea (HP:0007750)2.95379265
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.95379265
41Papillary thyroid carcinoma (HP:0002895)2.94534035
42Hypergonadotropic hypogonadism (HP:0000815)2.93967861
43Overlapping toe (HP:0001845)2.93814587
44Recurrent sinusitis (HP:0011108)2.87773416
45* Atelectasis (HP:0100750)2.82774079
46Supernumerary spleens (HP:0009799)2.81262474
47Arterial tortuosity (HP:0005116)2.81019674
48Cystic liver disease (HP:0006706)2.78909918
49Chronic bronchitis (HP:0004469)2.76822109
50Hypogonadotrophic hypogonadism (HP:0000044)2.76708115
51Chromsome breakage (HP:0040012)2.75694357
52Facial hemangioma (HP:0000329)2.73797898
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69643205
54Abnormality of alanine metabolism (HP:0010916)2.69643205
55Hyperalaninemia (HP:0003348)2.69643205
56Abnormality of chromosome segregation (HP:0002916)2.64017200
57Abnormality of the proximal phalanges of the hand (HP:0009834)2.60382017
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57614334
59Adrenal hypoplasia (HP:0000835)2.56628036
60Primary amenorrhea (HP:0000786)2.54009305
61Postaxial foot polydactyly (HP:0001830)2.52485297
62Tubulointerstitial nephritis (HP:0001970)2.49382438
63Anterior segment dysgenesis (HP:0007700)2.45769615
64Vascular tortuosity (HP:0004948)2.43302870
65Nephronophthisis (HP:0000090)2.39468958
66Myokymia (HP:0002411)2.37658067
67Pancreatic cysts (HP:0001737)2.35307048
68Neoplasm of striated muscle (HP:0009728)2.34286969
69Malnutrition (HP:0004395)2.33852621
70Spondylolisthesis (HP:0003302)2.33091741
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.29493173
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26476092
73Oral leukoplakia (HP:0002745)2.24020361
74Broad distal phalanx of finger (HP:0009836)2.22972217
75Camptodactyly of toe (HP:0001836)2.22270727
76Combined immunodeficiency (HP:0005387)2.21795981
77Sloping forehead (HP:0000340)2.20808150
78Sandal gap (HP:0001852)2.19839243
79Medial flaring of the eyebrow (HP:0010747)2.11490162
80Delayed puberty (HP:0000823)2.11458958
81Anencephaly (HP:0002323)2.10412005
82Irregular epiphyses (HP:0010582)2.08725259
83Abnormal lung lobation (HP:0002101)2.07792678
84Abnormal respiratory motile cilium physiology (HP:0012261)2.04540419
85Abnormality of the epiphysis of the femoral head (HP:0010574)2.04154044
86Hyperactive renin-angiotensin system (HP:0000841)2.03828840
87Fibular aplasia (HP:0002990)2.01247656
88Abnormality of lateral ventricle (HP:0030047)2.01078717
89Congenital primary aphakia (HP:0007707)2.00529301
90Abnormal respiratory motile cilium morphology (HP:0005938)10.6110414
91Abnormal respiratory epithelium morphology (HP:0012253)10.6110414
92Median cleft lip (HP:0000161)1.99703743
93Lip pit (HP:0100267)1.98397539
94Congenital hepatic fibrosis (HP:0002612)1.97550842
95Gait imbalance (HP:0002141)1.96374681
96Rhinitis (HP:0012384)1.96144151
97Thin ribs (HP:0000883)1.95384543
98Male pseudohermaphroditism (HP:0000037)1.93632368
99Preaxial hand polydactyly (HP:0001177)1.92717537
100Aplasia/Hypoplasia of the macula (HP:0008059)1.92645407
101Sclerocornea (HP:0000647)1.91922809
102Genu recurvatum (HP:0002816)1.91476745
103Hyperglycemia (HP:0003074)1.89413854
104Chronic hepatic failure (HP:0100626)1.88992917
105Arachnodactyly (HP:0001166)1.87533065
106Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.85417061
107Abnormality of femoral epiphyses (HP:0006499)1.85417061
108Morphological abnormality of the inner ear (HP:0011390)1.85298474
109Abnormality of the femoral head (HP:0003368)1.84951453
110Rib fusion (HP:0000902)1.84884569
111Chronic otitis media (HP:0000389)1.83794568
112Tubular atrophy (HP:0000092)1.83221997
113Abnormality of the labia majora (HP:0012881)1.82554865
114Shallow orbits (HP:0000586)1.82027209
115Hypoplastic iliac wings (HP:0002866)1.81724931
116Obstructive sleep apnea (HP:0002870)1.80870588
117Nephrogenic diabetes insipidus (HP:0009806)1.79068105
118Abnormality of the phalanges of the hallux (HP:0010057)1.76225959
119Testicular atrophy (HP:0000029)1.75937157
120Abnormality of the renal medulla (HP:0100957)1.75920582
121Oculomotor apraxia (HP:0000657)1.75383587
122Abnormal gallbladder physiology (HP:0012438)1.73651737
123Cholecystitis (HP:0001082)1.73651737
124Short nail (HP:0001799)1.72561799
125Aplasia/Hypoplasia affecting the retina (HP:0008061)1.71890723
126Postaxial hand polydactyly (HP:0001162)1.71788725
127Abnormality of the labia (HP:0000058)1.70957570
128Hypoplastic pelvis (HP:0008839)1.70710175
129Aplasia involving forearm bones (HP:0009822)1.70636038
130Absent forearm bone (HP:0003953)1.70636038
131Abnormality of the distal phalanges of the toes (HP:0010182)1.70111491
132Abnormal sex determination (HP:0012244)1.69111016
133Sex reversal (HP:0012245)1.69111016
134Absent radius (HP:0003974)1.68750604
135Posterior embryotoxon (HP:0000627)1.68750164
136Hypoplastic labia majora (HP:0000059)1.68719726
137Occipital encephalocele (HP:0002085)1.67761760
138Erectile abnormalities (HP:0100639)1.67144675
139Annular pancreas (HP:0001734)1.64298112
140Midline defect of the nose (HP:0004122)1.63602017
141Absent hand (HP:0004050)1.62812360
142Facial cleft (HP:0002006)1.62344648
143Amniotic constriction ring (HP:0009775)1.62335808
144Abnormality of placental membranes (HP:0011409)1.62335808
145Hypoplastic female external genitalia (HP:0012815)1.62082122
146Aplastic anemia (HP:0001915)1.60489147
147Hand muscle atrophy (HP:0009130)1.55880039
148Bell-shaped thorax (HP:0001591)1.53527197
149Abnormality of the dental root (HP:0006486)1.43443659
150Taurodontia (HP:0000679)1.43443659
151Abnormality of permanent molar morphology (HP:0011071)1.43443659
152Poor coordination (HP:0002370)1.33359345
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.31913932
154Asplenia (HP:0001746)1.31444090
155Tubulointerstitial abnormality (HP:0001969)1.31185443
156Furrowed tongue (HP:0000221)1.30855872
157Abnormal biliary tract physiology (HP:0012439)1.30073583
158Bile duct proliferation (HP:0001408)1.30073583
159Self-mutilation (HP:0000742)1.29732525
160Stage 5 chronic kidney disease (HP:0003774)1.29271566
161Optic nerve coloboma (HP:0000588)1.28970748
162Abnormality of molar morphology (HP:0011070)1.26957362
163Abnormality of molar (HP:0011077)1.26957362
164Flattened epiphyses (HP:0003071)1.23295181
165Polycystic kidney dysplasia (HP:0000113)1.22631926
166Distal upper limb amyotrophy (HP:0007149)1.21005091
167Upper limb amyotrophy (HP:0009129)1.21005091
168Abnormality of the dental pulp (HP:0006479)1.19294801
169Bifid scrotum (HP:0000048)1.16658302
170Genital tract atresia (HP:0001827)1.16495781
171Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.15842676
172Multicystic kidney dysplasia (HP:0000003)1.15578705
173Osteomalacia (HP:0002749)1.14162372
174Vaginal atresia (HP:0000148)1.13678070
175Prominent nasal bridge (HP:0000426)1.13016571
176Nephropathy (HP:0000112)1.11699183
177Retinitis pigmentosa (HP:0000510)1.11386518
178Aplasia/Hypoplasia involving the musculature (HP:0001460)1.10062058
179Renal salt wasting (HP:0000127)1.09566204
180Fetal akinesia sequence (HP:0001989)1.09370317
181Holoprosencephaly (HP:0001360)1.09273362
182Decreased circulating renin level (HP:0003351)1.08976535
183Aplasia/Hypoplasia of the sacrum (HP:0008517)1.08779817
184Pili torti (HP:0003777)1.08384626
185Absent frontal sinuses (HP:0002688)1.07606654
186Short thorax (HP:0010306)1.07466750
187Aplasia of the musculature (HP:0100854)1.07446395
188Microretrognathia (HP:0000308)1.07076030
189Aganglionic megacolon (HP:0002251)1.06837298
190Aplasia/Hypoplasia of the lens (HP:0008063)1.05754810
191Down-sloping shoulders (HP:0200021)1.05402502
192Abnormal drinking behavior (HP:0030082)1.04575103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.56846099
2BMPR25.60970814
3MOS5.51451357
4MAP3K65.11645738
5EPHA24.59382535
6TAOK33.74557496
7ERBB43.47605695
8TTK3.36113837
9LATS23.27865578
10KSR22.99698636
11PNCK2.93467275
12MST1R2.86066095
13LATS12.82845480
14MET2.76488963
15PLK42.73367033
16BRAF2.45606411
17PRKD32.39515706
18EEF2K2.35772717
19MAP3K92.28431997
20STK102.25209032
21MST42.24641488
22SMG12.13902772
23TAOK12.12054475
24MELK1.95629183
25STK38L1.93840458
26CDK81.93574646
27CDK121.86946106
28PRKCI1.74430231
29CDK191.72912945
30NEK61.67788757
31TESK11.65041561
32STK161.54793797
33NEK21.53728752
34CDC71.50427876
35BUB11.48164072
36MAP3K131.47681116
37PLK11.37241372
38ARAF1.36792872
39CHEK21.35488636
40BCKDK1.34413779
41PTK2B1.32419181
42PBK1.32229031
43NME21.27970331
44RAF11.27587131
45MAPK131.27109578
46NME11.23913119
47MAPKAPK31.23108737
48ICK1.20839771
49STK31.20112256
50PIM21.17728470
51MUSK1.15157762
52MAP3K81.13041174
53AURKA1.11327628
54BCR1.09119000
55CAMK1G1.05193542
56DYRK20.99820832
57PTK20.97252937
58CDK90.94788420
59TRIM280.93030789
60NLK0.91876618
61MAPKAPK50.91544651
62MAP3K20.91515696
63LIMK10.91331019
64LMTK20.89800280
65PRKD20.88142632
66PAK60.87842698
67CSNK1G10.83399064
68TSSK60.82261950
69ACVR1B0.81605450
70MAP3K40.80604373
71AURKB0.78032643
72KSR10.73184389
73RET0.71886720
74CAMKK10.70462457
75MAP3K30.68442238
76TLK10.67252107
77CAMKK20.65020951
78TYRO30.64282591
79BMX0.64069434
80TESK20.63662891
81IRAK30.62222955
82CCNB10.59778009
83CSNK1G30.58537912
84AKT20.57781595
85DMPK0.56432087
86PLK30.55764228
87PAK40.53976767
88TRPM70.52125024
89ABL20.51724972
90STK240.50899768
91VRK20.49636418
92CSNK1G20.49569074
93MAP2K40.49323324
94FER0.47001074
95CDK40.46667697
96MAP3K10.46512588
97ATR0.45424838
98RPS6KB20.45379237
99CSNK1A1L0.44852759
100MTOR0.44736383
101PLK20.43836039
102ILK0.40649186
103PDPK10.38630526
104EPHA40.36328569
105EIF2AK20.35745321
106STK380.35640428
107CDK70.35590151
108ERBB20.35199995
109CAMK2G0.32075417
110PRKAA10.31766359
111EPHB10.31337661
112MAP2K70.31299693
113EIF2AK10.31069850
114MAP3K50.29415469
115SIK30.28330305
116SIK10.27537288
117ATM0.26832633
118PAK10.26498013
119DYRK30.26486986
120TAOK20.26473100
121STK110.26351116
122CAMK1D0.26286648
123BRSK20.25550021
124RPS6KA40.25222639
125ABL10.24991119
126MAP2K20.24859246
127PDK20.24820662
128WEE10.24695382
129CHEK10.24391308
130PIM10.23886308
131CDK11A0.22566549
132MAP2K10.22504694
133CDK20.21928863
134CDK10.21857389
135RPS6KA10.21089403
136MAPK110.20810201
137LRRK20.20364790
138RPS6KA20.19334506
139BRSK10.18037116
140JAK20.17156650
141TRIB30.17040825
142PRKAA20.16891190
143MAP3K120.15513211
144VRK10.14015475
145SGK2230.12892658
146SGK4940.12892658
147CSNK1D0.12584395
148MARK20.12548695
149HIPK20.11154269
150AKT10.10971267
151SGK20.10768019
152MAP3K110.06913617
153CAMK2A0.06542359

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.28929125
2Basal transcription factors_Homo sapiens_hsa030224.16627323
3Cell cycle_Homo sapiens_hsa041103.66253830
4Phenylalanine metabolism_Homo sapiens_hsa003603.63138348
5Vitamin B6 metabolism_Homo sapiens_hsa007503.34042277
6Huntingtons disease_Homo sapiens_hsa050163.10020825
7RNA degradation_Homo sapiens_hsa030183.01256906
8Oocyte meiosis_Homo sapiens_hsa041142.99009835
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.95957709
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.58013463
11Tyrosine metabolism_Homo sapiens_hsa003502.40398758
12Circadian rhythm_Homo sapiens_hsa047102.28902214
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27555820
14Chemical carcinogenesis_Homo sapiens_hsa052042.18411758
15Homologous recombination_Homo sapiens_hsa034402.15868055
16RNA transport_Homo sapiens_hsa030132.13934091
17Pancreatic cancer_Homo sapiens_hsa052122.10317289
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06899745
19GnRH signaling pathway_Homo sapiens_hsa049122.05697309
20Fanconi anemia pathway_Homo sapiens_hsa034602.00376761
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93439558
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89661474
23Sulfur relay system_Homo sapiens_hsa041221.89527826
24RNA polymerase_Homo sapiens_hsa030201.88171019
25Base excision repair_Homo sapiens_hsa034101.87384082
26Glutathione metabolism_Homo sapiens_hsa004801.79310109
27Dorso-ventral axis formation_Homo sapiens_hsa043201.79097204
28Other glycan degradation_Homo sapiens_hsa005111.74283508
29mRNA surveillance pathway_Homo sapiens_hsa030151.67094437
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64115018
31TGF-beta signaling pathway_Homo sapiens_hsa043501.62512965
32Mismatch repair_Homo sapiens_hsa034301.62252792
33beta-Alanine metabolism_Homo sapiens_hsa004101.58548244
34Non-homologous end-joining_Homo sapiens_hsa034501.56927422
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56258212
36Linoleic acid metabolism_Homo sapiens_hsa005911.47943117
37Colorectal cancer_Homo sapiens_hsa052101.45353446
38Ribosome_Homo sapiens_hsa030101.44644382
39MicroRNAs in cancer_Homo sapiens_hsa052061.42052387
40DNA replication_Homo sapiens_hsa030301.39442786
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38928920
42Ether lipid metabolism_Homo sapiens_hsa005651.34094750
43Prolactin signaling pathway_Homo sapiens_hsa049171.21510054
44mTOR signaling pathway_Homo sapiens_hsa041501.19801174
45VEGF signaling pathway_Homo sapiens_hsa043701.19518702
46Bladder cancer_Homo sapiens_hsa052191.16615689
47Nucleotide excision repair_Homo sapiens_hsa034201.15094168
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12861872
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.12427678
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08245402
51Caffeine metabolism_Homo sapiens_hsa002321.07998142
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07392850
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02955966
54Hippo signaling pathway_Homo sapiens_hsa043901.02922785
55Tight junction_Homo sapiens_hsa045300.97412045
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97403671
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95059684
58Fructose and mannose metabolism_Homo sapiens_hsa000510.94911255
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94382711
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93393543
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.91597294
62Oxidative phosphorylation_Homo sapiens_hsa001900.91168946
63Retinol metabolism_Homo sapiens_hsa008300.90964925
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89573929
65p53 signaling pathway_Homo sapiens_hsa041150.89498225
66Pentose phosphate pathway_Homo sapiens_hsa000300.86821311
67Vibrio cholerae infection_Homo sapiens_hsa051100.85842650
68N-Glycan biosynthesis_Homo sapiens_hsa005100.84326844
69Inositol phosphate metabolism_Homo sapiens_hsa005620.83343507
70Chronic myeloid leukemia_Homo sapiens_hsa052200.83069864
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82166520
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81693597
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81054990
74Synaptic vesicle cycle_Homo sapiens_hsa047210.81042018
75Regulation of autophagy_Homo sapiens_hsa041400.78149944
76Renal cell carcinoma_Homo sapiens_hsa052110.78110422
77Long-term depression_Homo sapiens_hsa047300.75885578
78ABC transporters_Homo sapiens_hsa020100.75769661
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75563540
80Choline metabolism in cancer_Homo sapiens_hsa052310.75335036
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.75174648
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.74694488
83Purine metabolism_Homo sapiens_hsa002300.73518456
84Spliceosome_Homo sapiens_hsa030400.72060894
85Metabolic pathways_Homo sapiens_hsa011000.71875450
86FoxO signaling pathway_Homo sapiens_hsa040680.71483140
87Shigellosis_Homo sapiens_hsa051310.70877259
88Gap junction_Homo sapiens_hsa045400.68314968
89Pyrimidine metabolism_Homo sapiens_hsa002400.67084552
90Cardiac muscle contraction_Homo sapiens_hsa042600.66434538
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66293715
92Non-small cell lung cancer_Homo sapiens_hsa052230.66204703
93Collecting duct acid secretion_Homo sapiens_hsa049660.65740878
94Thyroid cancer_Homo sapiens_hsa052160.64726421
95Biosynthesis of amino acids_Homo sapiens_hsa012300.64058111
96Fatty acid biosynthesis_Homo sapiens_hsa000610.63772134
97Adherens junction_Homo sapiens_hsa045200.63559383
98Parkinsons disease_Homo sapiens_hsa050120.63403295
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62546582
100Estrogen signaling pathway_Homo sapiens_hsa049150.60050557
101Glioma_Homo sapiens_hsa052140.59111527
102Endometrial cancer_Homo sapiens_hsa052130.58992233
103Peroxisome_Homo sapiens_hsa041460.58823641
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58727712
105Basal cell carcinoma_Homo sapiens_hsa052170.56870280
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55162513
107Hepatitis B_Homo sapiens_hsa051610.55006878
108Ras signaling pathway_Homo sapiens_hsa040140.52618704
109HTLV-I infection_Homo sapiens_hsa051660.51516338
110Notch signaling pathway_Homo sapiens_hsa043300.50030904
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49095031
112Arginine biosynthesis_Homo sapiens_hsa002200.46383326
113Small cell lung cancer_Homo sapiens_hsa052220.46192810
114Arachidonic acid metabolism_Homo sapiens_hsa005900.46074500
115MAPK signaling pathway_Homo sapiens_hsa040100.45687682
116Carbon metabolism_Homo sapiens_hsa012000.44513209
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.42204918
118Fatty acid degradation_Homo sapiens_hsa000710.41765402
119Alzheimers disease_Homo sapiens_hsa050100.41522520
120Sphingolipid metabolism_Homo sapiens_hsa006000.41324483
121Melanoma_Homo sapiens_hsa052180.39571041
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38537095
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38395673
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37120382
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.37102398
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35290162
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34642817
128Steroid biosynthesis_Homo sapiens_hsa001000.34400011
129Fatty acid elongation_Homo sapiens_hsa000620.34215979
130Epstein-Barr virus infection_Homo sapiens_hsa051690.33571554
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32135908
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31438403
133Salivary secretion_Homo sapiens_hsa049700.31065503
134Viral carcinogenesis_Homo sapiens_hsa052030.31045965
135Apoptosis_Homo sapiens_hsa042100.29931424
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29668527
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.29405801
138Folate biosynthesis_Homo sapiens_hsa007900.29281736
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.28865811
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28823723
141Arginine and proline metabolism_Homo sapiens_hsa003300.25769119
142Pathways in cancer_Homo sapiens_hsa052000.24378919
143ErbB signaling pathway_Homo sapiens_hsa040120.24019842
144Insulin signaling pathway_Homo sapiens_hsa049100.23654857
145Long-term potentiation_Homo sapiens_hsa047200.23350447
146Histidine metabolism_Homo sapiens_hsa003400.22890308
147Prostate cancer_Homo sapiens_hsa052150.22884974
148Wnt signaling pathway_Homo sapiens_hsa043100.21410204
149Hedgehog signaling pathway_Homo sapiens_hsa043400.20789533
150Olfactory transduction_Homo sapiens_hsa047400.20366694
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19598395
152Pyruvate metabolism_Homo sapiens_hsa006200.19261639

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