CCNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA methylation (GO:0031167)7.53714653
2rRNA modification (GO:0000154)7.00877343
3regulation of RNA export from nucleus (GO:0046831)4.61188714
4chromosome condensation (GO:0030261)4.36716897
5mitotic chromosome condensation (GO:0007076)4.26131921
6regulation of centrosome duplication (GO:0010824)4.17129083
7DNA packaging (GO:0006323)4.10827949
8mitotic sister chromatid cohesion (GO:0007064)3.98830706
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.96861284
10sister chromatid segregation (GO:0000819)3.96381869
11negative regulation of DNA repair (GO:0045738)3.91480128
12regulation of centrosome cycle (GO:0046605)3.89852511
13pre-miRNA processing (GO:0031054)3.86618240
14monoubiquitinated protein deubiquitination (GO:0035520)3.82808124
15nuclear envelope disassembly (GO:0051081)3.82630104
16membrane disassembly (GO:0030397)3.82630104
17ribosome assembly (GO:0042255)3.82411609
18regulation of nucleobase-containing compound transport (GO:0032239)3.82210260
19DNA topological change (GO:0006265)3.78076041
20nuclear pore complex assembly (GO:0051292)3.71090054
21nucleus organization (GO:0006997)3.65790519
22histone H3-K36 demethylation (GO:0070544)3.63464937
23mitotic sister chromatid segregation (GO:0000070)3.63402755
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.62844850
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.61752318
26regulation of DNA endoreduplication (GO:0032875)3.61586355
27nuclear pore organization (GO:0006999)3.58155105
28protein localization to chromosome, centromeric region (GO:0071459)3.55135770
29protein localization to kinetochore (GO:0034501)3.54261481
30histone H3-K4 trimethylation (GO:0080182)3.50691846
31DNA conformation change (GO:0071103)3.50084909
32negative regulation of histone acetylation (GO:0035067)3.47852204
33DNA replication-independent nucleosome assembly (GO:0006336)3.47762626
34DNA replication-independent nucleosome organization (GO:0034724)3.47762626
35alternative mRNA splicing, via spliceosome (GO:0000380)3.39524604
36kinetochore organization (GO:0051383)3.38059653
37DNA duplex unwinding (GO:0032508)3.37380960
38DNA geometric change (GO:0032392)3.31417903
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.30960963
40negative regulation of histone methylation (GO:0031061)3.29535050
41CENP-A containing nucleosome assembly (GO:0034080)3.28455382
42regulation of chromatin silencing (GO:0031935)3.27297065
43mRNA splice site selection (GO:0006376)3.26381135
44chromatin remodeling at centromere (GO:0031055)3.25947662
45DNA ligation (GO:0006266)3.25763949
46RNA methylation (GO:0001510)3.13599194
47double-strand break repair via nonhomologous end joining (GO:0006303)3.12867915
48non-recombinational repair (GO:0000726)3.12867915
49regulation of DNA damage checkpoint (GO:2000001)3.11883946
50regulation of chromosome segregation (GO:0051983)3.08715879
51DNA synthesis involved in DNA repair (GO:0000731)3.08513856
52regulation of spindle organization (GO:0090224)3.08157464
53metaphase plate congression (GO:0051310)3.07777578
54kinetochore assembly (GO:0051382)3.05298125
55prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.04962954
56mitotic metaphase plate congression (GO:0007080)3.01617980
57regulation of mitotic spindle organization (GO:0060236)2.99658106
58negative regulation of phagocytosis (GO:0050765)2.98739680
59centriole replication (GO:0007099)2.97786295
60centriole assembly (GO:0098534)2.97252396
61regulation of transcription from RNA polymerase I promoter (GO:0006356)2.95761911
62spermatid nucleus differentiation (GO:0007289)2.95223135
63negative regulation of peptidyl-lysine acetylation (GO:2000757)2.94692644
64mRNA transport (GO:0051028)2.93151831
65regulation of sister chromatid cohesion (GO:0007063)2.92707836
66nuclear envelope organization (GO:0006998)2.92292216
67negative regulation of gene silencing (GO:0060969)2.91503198
68protein K11-linked deubiquitination (GO:0035871)2.90629857
69V(D)J recombination (GO:0033151)2.89301349
70cytoplasmic mRNA processing body assembly (GO:0033962)2.88839429
71NLS-bearing protein import into nucleus (GO:0006607)2.88550422
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87133568
73intra-S DNA damage checkpoint (GO:0031573)2.86721482
74anterior/posterior axis specification, embryo (GO:0008595)2.86466060
75DNA unwinding involved in DNA replication (GO:0006268)2.83813499
76positive regulation of histone H3-K4 methylation (GO:0051571)2.82718735
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79624571
78spliceosomal complex assembly (GO:0000245)2.77591532
79interferon-gamma production (GO:0032609)2.77497361
80single strand break repair (GO:0000012)2.76758735
81regulation of histone H3-K9 methylation (GO:0051570)2.76715028
82pore complex assembly (GO:0046931)2.75644261
83regulation of histone methylation (GO:0031060)2.75524846
84histone demethylation (GO:0016577)2.75157810
85spindle checkpoint (GO:0031577)2.73799396
86regulation of double-strand break repair via homologous recombination (GO:0010569)2.73669803
87mitotic G2/M transition checkpoint (GO:0044818)2.72903330
88protein K48-linked deubiquitination (GO:0071108)2.72824229
89sister chromatid cohesion (GO:0007062)2.72075216
90regulation of centriole replication (GO:0046599)2.72062622
91DNA strand elongation involved in DNA replication (GO:0006271)2.71515375
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71342324
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71342324
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.71342324
95DNA dealkylation (GO:0035510)2.70812874
96positive regulation of histone methylation (GO:0031062)2.70071916
97histone mRNA catabolic process (GO:0071044)2.69688558
98peptidyl-lysine trimethylation (GO:0018023)2.69414464
99IMP biosynthetic process (GO:0006188)2.68541155
100regulation of translation, ncRNA-mediated (GO:0045974)2.68424298
101negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68424298
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.68424298
103peptidyl-threonine dephosphorylation (GO:0035970)2.68207242
104protein localization to chromosome (GO:0034502)2.67934869
105nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67647749
106nucleic acid transport (GO:0050657)2.67382287
107RNA transport (GO:0050658)2.67382287
108establishment of RNA localization (GO:0051236)2.67382287
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.67059727
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.67059727
111genitalia morphogenesis (GO:0035112)2.66939830
112mRNA export from nucleus (GO:0006406)2.66735403
113peptidyl-lysine methylation (GO:0018022)2.66261163
114regulation of mRNA splicing, via spliceosome (GO:0048024)2.66116385
115cytokine production involved in immune response (GO:0002367)2.65517658
116regulation of mitotic sister chromatid segregation (GO:0033047)2.65117167
117regulation of sister chromatid segregation (GO:0033045)2.65117167
118regulation of mitotic sister chromatid separation (GO:0010965)2.65117167
119natural killer cell activation involved in immune response (GO:0002323)2.65047650
120mitotic spindle checkpoint (GO:0071174)2.64945283
121spliceosomal tri-snRNP complex assembly (GO:0000244)2.64300895
122intracellular estrogen receptor signaling pathway (GO:0030520)2.63768349
123DNA replication checkpoint (GO:0000076)2.63591982
124chromosome segregation (GO:0007059)2.63145082
125protein targeting to Golgi (GO:0000042)2.63074584
126dosage compensation (GO:0007549)2.62459554
127establishment of protein localization to Golgi (GO:0072600)2.62175322
128telomere maintenance via telomerase (GO:0007004)2.61887559
129RNA export from nucleus (GO:0006405)2.61720437
130G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61642093
131DNA strand elongation (GO:0022616)2.60889682
132positive regulation of cell cycle checkpoint (GO:1901978)2.60800064
133response to UV-C (GO:0010225)2.60697134
134DNA replication initiation (GO:0006270)2.60506946
135positive regulation of chromosome segregation (GO:0051984)2.59397430
136negative regulation of protein acetylation (GO:1901984)2.57627296
137positive regulation of cellular response to oxidative stress (GO:1900409)2.56672500
138positive regulation of response to oxidative stress (GO:1902884)2.56672500
139purine deoxyribonucleotide catabolic process (GO:0009155)2.56407863
140protein K6-linked ubiquitination (GO:0085020)2.55270863
141mitotic recombination (GO:0006312)2.54815158
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54705388
143telomere maintenance via semi-conservative replication (GO:0032201)2.53335131
144regulation of RNA splicing (GO:0043484)2.52646787
145histone exchange (GO:0043486)2.52641175
146regulation of DNA-dependent DNA replication (GO:0090329)2.49987426
147regulation of relaxation of muscle (GO:1901077)2.49128480
148positive regulation of mRNA processing (GO:0050685)2.47369615
149DNA-dependent DNA replication (GO:0006261)2.47181828
150transcription-coupled nucleotide-excision repair (GO:0006283)2.46727883
151regulation of mRNA processing (GO:0050684)2.46134018
152chromatin assembly or disassembly (GO:0006333)2.45551618
153peptidyl-arginine omega-N-methylation (GO:0035247)2.45347360
154cartilage morphogenesis (GO:0060536)2.44946456
155regulation of telomere maintenance (GO:0032204)2.44793407
156retinal cone cell development (GO:0046549)2.44177119
157regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.44051593
158regulation of mitotic spindle checkpoint (GO:1903504)2.43460581
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.43460581
160B cell homeostasis (GO:0001782)2.43207852
161regulation of histone H3-K27 methylation (GO:0061085)2.42983230
162positive regulation of DNA-dependent DNA replication (GO:2000105)2.42845057
1637-methylguanosine mRNA capping (GO:0006370)2.42359193
164negative regulation of histone modification (GO:0031057)2.42181411
165microtubule depolymerization (GO:0007019)2.41635813
166dendritic cell chemotaxis (GO:0002407)2.41040232
167base-excision repair, AP site formation (GO:0006285)2.40680602
168telomere maintenance via telomere lengthening (GO:0010833)2.40498115
169RNA capping (GO:0036260)2.40038827
1707-methylguanosine RNA capping (GO:0009452)2.40038827
171meiotic chromosome segregation (GO:0045132)2.38298542
172mitotic nuclear envelope disassembly (GO:0007077)2.37993002
173RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.37057155
174mRNA splicing, via spliceosome (GO:0000398)2.37057155
175protein dealkylation (GO:0008214)2.37019176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18936144
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.18181644
3* TP63_19390658_ChIP-ChIP_HaCaT_Human3.34697990
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11941609
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.99506771
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.90927985
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71735807
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.66872511
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59918487
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.40801414
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.38248117
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26153765
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.17518600
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11178789
15* ELK1_19687146_ChIP-ChIP_HELA_Human2.08530492
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02110629
17* E2F1_21310950_ChIP-Seq_MCF-7_Human1.96858803
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95719390
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94650517
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92421909
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80455921
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79932462
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77592540
24IRF1_19129219_ChIP-ChIP_H3396_Human1.74298745
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73616787
26* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73201570
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71150746
28* VDR_23849224_ChIP-Seq_CD4+_Human1.70711303
29SCL_19346495_ChIP-Seq_HPC-7_Human1.67292132
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.67133794
31* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.67022237
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66057168
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65353918
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56800145
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.56113717
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55472948
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55170460
38EWS_26573619_Chip-Seq_HEK293_Human1.54366204
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54044387
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.52963560
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52586544
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52547470
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52489256
44* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52289029
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52137451
46CIITA_25753668_ChIP-Seq_RAJI_Human1.41945437
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40667276
48* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38343688
49* GABP_17652178_ChIP-ChIP_JURKAT_Human1.36844675
50* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35150899
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35100751
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32422980
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31365066
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31132869
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30032209
56* EST1_17652178_ChIP-ChIP_JURKAT_Human1.29605977
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29595400
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28726549
59FUS_26573619_Chip-Seq_HEK293_Human1.26837077
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26736267
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25440577
62* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24745652
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24066259
64* CHD1_26751641_Chip-Seq_LNCaP_Human1.23136749
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22546739
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22246138
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.20298983
68TAF15_26573619_Chip-Seq_HEK293_Human1.20190095
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.19691246
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19156666
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18954467
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18189100
73TP53_16413492_ChIP-PET_HCT116_Human1.16019382
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14964398
75GBX2_23144817_ChIP-Seq_PC3_Human1.14790739
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14578715
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.13617544
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12930418
79KDM5A_27292631_Chip-Seq_BREAST_Human1.11651079
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11456815
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11414448
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11335975
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10763391
84TTF2_22483619_ChIP-Seq_HELA_Human1.10673137
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10615147
86MYB_26560356_Chip-Seq_TH2_Human1.10210222
87P300_18555785_Chip-Seq_ESCs_Mouse1.09664780
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07762262
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.07671612
90* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07641683
91MYC_18940864_ChIP-ChIP_HL60_Human1.07508938
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06987310
93P53_22387025_ChIP-Seq_ESCs_Mouse1.06491500
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06021407
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.05357815
96AR_21909140_ChIP-Seq_LNCAP_Human1.04696407
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04517488
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03400376
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.02699722
100BP1_19119308_ChIP-ChIP_Hs578T_Human1.02339051
101MYB_26560356_Chip-Seq_TH1_Human1.02155188
102PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00630099
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.00309126
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00087691
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99984666
106STAT3_18555785_Chip-Seq_ESCs_Mouse0.98856035
107FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98740777
108MYC_22102868_ChIP-Seq_BL_Human0.98728914
109* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98651995
110OCT4_18555785_Chip-Seq_ESCs_Mouse0.98464753
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98157882
112* TFEB_21752829_ChIP-Seq_HELA_Human0.98064535
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95689301
114ER_23166858_ChIP-Seq_MCF-7_Human0.95639158
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95599698
116* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95545165
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95387527
118SALL4_22934838_ChIP-ChIP_CD34+_Human0.93890035
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93786569
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93145378
121* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92031087
122RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91639940
123BRD4_25478319_ChIP-Seq_HGPS_Human0.91548814
124DCP1A_22483619_ChIP-Seq_HELA_Human0.91519045
125ZFX_18555785_Chip-Seq_ESCs_Mouse0.90036453
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89424101
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89350405
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88366714
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88315870
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88154059
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84252518
132GATA1_22025678_ChIP-Seq_K562_Human0.80616905
133* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80536999
134* SOX17_20123909_ChIP-Seq_XEN_Mouse0.76876534
135STAT3_23295773_ChIP-Seq_U87_Human0.75861930
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.75699570
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73434755
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72589288
139CBP_20019798_ChIP-Seq_JUKART_Human0.70637411
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.70637411
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.70338012
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70338012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.88408802
2MP0010094_abnormal_chromosome_stability3.44330400
3MP0001188_hyperpigmentation3.19021710
4MP0008007_abnormal_cellular_replicative2.82077862
5MP0006292_abnormal_olfactory_placode2.76280686
6MP0003111_abnormal_nucleus_morphology2.62593885
7MP0008877_abnormal_DNA_methylation2.48381528
8MP0002396_abnormal_hematopoietic_system2.41078021
9MP0003787_abnormal_imprinting2.38181183
10MP0002132_abnormal_respiratory_system2.34703917
11MP0008058_abnormal_DNA_repair2.34266260
12MP0002163_abnormal_gland_morphology2.33719764
13MP0005409_darkened_coat_color2.25678265
14MP0001293_anophthalmia2.23997547
15MP0003077_abnormal_cell_cycle2.18772266
16MP0000566_synostosis2.06723300
17MP0002877_abnormal_melanocyte_morpholog2.03548932
18MP0005076_abnormal_cell_differentiation1.98162514
19MP0003693_abnormal_embryo_hatching1.97415866
20MP0010234_abnormal_vibrissa_follicle1.94039477
21MP0001348_abnormal_lacrimal_gland1.91306556
22MP0002938_white_spotting1.79339898
23MP0009697_abnormal_copulation1.77803165
24MP0003121_genomic_imprinting1.72401943
25MP0003763_abnormal_thymus_physiology1.70975140
26MP0004808_abnormal_hematopoietic_stem1.68125687
27MP0002088_abnormal_embryonic_growth/wei1.65409546
28MP0001873_stomach_inflammation1.65297152
29MP0001697_abnormal_embryo_size1.60960614
30MP0004233_abnormal_muscle_weight1.60627543
31MP0003890_abnormal_embryonic-extraembry1.57313444
32MP0000703_abnormal_thymus_morphology1.57148627
33MP0002277_abnormal_respiratory_mucosa1.56988579
34MP0002084_abnormal_developmental_patter1.53018148
35MP0002086_abnormal_extraembryonic_tissu1.51522803
36MP0010352_gastrointestinal_tract_polyps1.46625972
37MP0003786_premature_aging1.45599179
38MP0005379_endocrine/exocrine_gland_phen1.43620325
39MP0002095_abnormal_skin_pigmentation1.43428232
40MP0005410_abnormal_fertilization1.42894089
41MP0004264_abnormal_extraembryonic_tissu1.41256380
42MP0004381_abnormal_hair_follicle1.41113114
43MP0003136_yellow_coat_color1.40931584
44MP0005171_absent_coat_pigmentation1.38612170
45MP0002398_abnormal_bone_marrow1.37740662
46MP0001929_abnormal_gametogenesis1.34425029
47MP0000537_abnormal_urethra_morphology1.32128465
48MP0002080_prenatal_lethality1.27539927
49MP0002697_abnormal_eye_size1.26788758
50MP0000490_abnormal_crypts_of1.24518907
51MP0002092_abnormal_eye_morphology1.24055250
52MP0004185_abnormal_adipocyte_glucose1.23190468
53MP0001800_abnormal_humoral_immune1.21681185
54MP0004957_abnormal_blastocyst_morpholog1.21234736
55MP0002006_tumorigenesis1.19984359
56MP0001919_abnormal_reproductive_system1.17014743
57MP0003221_abnormal_cardiomyocyte_apopto1.16696107
58MP0000569_abnormal_digit_pigmentation1.16285907
59MP0005367_renal/urinary_system_phenotyp1.15538556
60MP0000516_abnormal_urinary_system1.15538556
61MP0010678_abnormal_skin_adnexa1.15305346
62MP0002928_abnormal_bile_duct1.15206185
63MP0002638_abnormal_pupillary_reflex1.14464120
64MP0001286_abnormal_eye_development1.14417954
65MP0003718_maternal_effect1.13217183
66MP0006072_abnormal_retinal_apoptosis1.11857286
67MP0002722_abnormal_immune_system1.11357937
68MP0005391_vision/eye_phenotype1.11339281
69MP0000350_abnormal_cell_proliferation1.11270662
70MP0002009_preneoplasia1.08100061
71MP0002102_abnormal_ear_morphology1.07674298
72MP0002420_abnormal_adaptive_immunity1.07270446
73MP0002452_abnormal_antigen_presenting1.06702546
74MP0005248_abnormal_Harderian_gland1.06644819
75MP0003123_paternal_imprinting1.05640125
76MP0000716_abnormal_immune_system1.04651921
77MP0001819_abnormal_immune_cell1.04511341
78MP0000689_abnormal_spleen_morphology1.02800768
79MP0009672_abnormal_birth_weight1.01767723
80MP0002075_abnormal_coat/hair_pigmentati1.00985631
81MP0002160_abnormal_reproductive_system1.00207377
82MP0000015_abnormal_ear_pigmentation0.99683287
83MP0010307_abnormal_tumor_latency0.98702537
84MP0001186_pigmentation_phenotype0.98582578
85MP0009703_decreased_birth_body0.98482632
86MP0002723_abnormal_immune_serum0.98256455
87MP0008932_abnormal_embryonic_tissue0.97849629
88MP0000681_abnormal_thyroid_gland0.97575278
89MP0000427_abnormal_hair_cycle0.97509569
90MP0003937_abnormal_limbs/digits/tail_de0.97428644
91MP0005671_abnormal_response_to0.97240061
92MP0003828_pulmonary_edema0.95099085
93MP0005000_abnormal_immune_tolerance0.93648814
94MP0003698_abnormal_male_reproductive0.92873541
95MP0000432_abnormal_head_morphology0.92203316
96MP0000428_abnormal_craniofacial_morphol0.92048904
97MP0002210_abnormal_sex_determination0.91988094
98MP0000372_irregular_coat_pigmentation0.91877789
99MP0005174_abnormal_tail_pigmentation0.91828278
100MP0000371_diluted_coat_color0.91083345
101MP0002429_abnormal_blood_cell0.90017332
102MP0003943_abnormal_hepatobiliary_system0.89069298
103MP0003941_abnormal_skin_development0.88636244
104MP0005397_hematopoietic_system_phenotyp0.88447955
105MP0001545_abnormal_hematopoietic_system0.88447955
106MP0002166_altered_tumor_susceptibility0.87636797
107MP0005389_reproductive_system_phenotype0.86849853
108MP0002019_abnormal_tumor_incidence0.85906578
109MP0000313_abnormal_cell_death0.85803310
110MP0005408_hypopigmentation0.84143712
111MP0005380_embryogenesis_phenotype0.82717203
112MP0001672_abnormal_embryogenesis/_devel0.82717203
113MP0000733_abnormal_muscle_development0.80483949
114MP0003755_abnormal_palate_morphology0.80244362
115MP0001835_abnormal_antigen_presentation0.80119844
116MP0003448_altered_tumor_morphology0.79809116
117MP0001986_abnormal_taste_sensitivity0.79787759
118MP0005310_abnormal_salivary_gland0.79629011
119MP0001145_abnormal_male_reproductive0.79581432
120MP0005621_abnormal_cell_physiology0.79355459
121MP0001853_heart_inflammation0.77034567
122MP0003315_abnormal_perineum_morphology0.76992199
123MP0005253_abnormal_eye_physiology0.76632545
124MP0002233_abnormal_nose_morphology0.76376887
125MP0005187_abnormal_penis_morphology0.74416056
126MP0000377_abnormal_hair_follicle0.74217056
127MP0003567_abnormal_fetal_cardiomyocyte0.73998017
128MP0003705_abnormal_hypodermis_morpholog0.73988942
129MP0003935_abnormal_craniofacial_develop0.73463812
130MP0000653_abnormal_sex_gland0.73195956
131MP0003699_abnormal_female_reproductive0.73075076
132MP0005384_cellular_phenotype0.72470433
133MP0004197_abnormal_fetal_growth/weight/0.71975178
134MP0001346_abnormal_lacrimal_gland0.71508076
135MP0008995_early_reproductive_senescence0.71491519
136MP0002085_abnormal_embryonic_tissue0.69406345
137MP0000383_abnormal_hair_follicle0.68770931
138MP0003984_embryonic_growth_retardation0.68508825
139MP0000613_abnormal_salivary_gland0.68424869
140MP0003656_abnormal_erythrocyte_physiolo0.68140851
141MP0005623_abnormal_meninges_morphology0.67981466
142MP0001730_embryonic_growth_arrest0.67635425
143MP0005464_abnormal_platelet_physiology0.67116066
144MP0008961_abnormal_basal_metabolism0.67079443
145MP0003936_abnormal_reproductive_system0.64560550
146MP0001727_abnormal_embryo_implantation0.64392347
147MP0003950_abnormal_plasma_membrane0.64031956
148MP0002161_abnormal_fertility/fecundity0.63911795
149MP0001119_abnormal_female_reproductive0.63785835

Predicted human phenotypes

RankGene SetZ-score
1Spinal cord lesions (HP:0100561)4.64931316
2Syringomyelia (HP:0003396)4.64931316
3Absent frontal sinuses (HP:0002688)3.86149381
4Chromsome breakage (HP:0040012)3.61058543
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50175489
6Papillary thyroid carcinoma (HP:0002895)3.29789438
7Volvulus (HP:0002580)3.28058451
8Cystic hygroma (HP:0000476)3.17012229
9Nephroblastoma (Wilms tumor) (HP:0002667)3.10754852
10Curly hair (HP:0002212)3.06874255
11Embryonal renal neoplasm (HP:0011794)3.03078856
12Rhabdomyosarcoma (HP:0002859)3.02254936
13Supernumerary ribs (HP:0005815)2.96299847
14Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.93503226
15Supernumerary bones of the axial skeleton (HP:0009144)2.86311117
16Duplicated collecting system (HP:0000081)2.78779020
17Abnormality of the frontal sinuses (HP:0002687)2.73703791
18Birth length less than 3rd percentile (HP:0003561)2.73483744
19Popliteal pterygium (HP:0009756)2.71585593
20Ectopic kidney (HP:0000086)2.69029545
21Truncal obesity (HP:0001956)2.65695012
22Abnormality of the renal collecting system (HP:0004742)2.58774325
23Abnormality of the labia minora (HP:0012880)2.58750108
24Sandal gap (HP:0001852)2.57759323
25Menstrual irregularities (HP:0000858)2.56223287
26Abnormality of the preputium (HP:0100587)2.55573984
27Chronic hepatic failure (HP:0100626)2.52464280
28Fatigue (HP:0012378)2.51973719
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.50181930
30Abnormality of chromosome stability (HP:0003220)2.44265768
31Asymmetry of the thorax (HP:0001555)2.41583437
32Abnormal number of incisors (HP:0011064)2.40125119
33Meckel diverticulum (HP:0002245)2.39973738
34Short middle phalanx of the 5th finger (HP:0004220)2.38386583
35Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.36982416
36Premature graying of hair (HP:0002216)2.35358571
37Abnormality of the fingertips (HP:0001211)2.34901928
38Obsessive-compulsive behavior (HP:0000722)2.34624663
39Subacute progressive viral hepatitis (HP:0006572)2.32540456
40Overlapping toe (HP:0001845)2.32004525
41Chronic diarrhea (HP:0002028)2.31344722
42Abnormality of the ileum (HP:0001549)2.29411492
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.24735042
44Neoplasm of striated muscle (HP:0009728)2.23455777
45Cafe-au-lait spot (HP:0000957)2.22249086
46Alveolar cell carcinoma (HP:0006519)2.22174225
47Acute lymphatic leukemia (HP:0006721)2.20785741
48Neoplasm of the tracheobronchial system (HP:0100552)2.20158947
49Astrocytoma (HP:0009592)2.19420354
50Abnormality of the astrocytes (HP:0100707)2.19420354
51Congenital stationary night blindness (HP:0007642)2.19412728
52Abnormality of the parietal bone (HP:0002696)2.17688465
53Stomatitis (HP:0010280)2.17293599
54Glioma (HP:0009733)2.14090639
55Thyroid carcinoma (HP:0002890)2.14041398
56Clubbing of toes (HP:0100760)2.13747309
57Malignant gastrointestinal tract tumors (HP:0006749)2.12328170
58Gastrointestinal carcinoma (HP:0002672)2.12328170
59Transitional cell carcinoma of the bladder (HP:0006740)2.10349641
60Abnormality of chromosome segregation (HP:0002916)2.09558309
61Long eyelashes (HP:0000527)2.09455452
62Long clavicles (HP:0000890)2.06623304
63Agammaglobulinemia (HP:0004432)2.06450087
64Generalized hypopigmentation of hair (HP:0011358)2.06217146
65Autoimmune hemolytic anemia (HP:0001890)2.05878888
66Abnormality of the incisor (HP:0000676)2.02813559
67Cubitus valgus (HP:0002967)2.02787652
68Urethral obstruction (HP:0000796)2.02556275
69Sloping forehead (HP:0000340)2.02004879
70Abnormality of the carotid arteries (HP:0005344)2.00938694
71Aplastic anemia (HP:0001915)2.00283500
72Low anterior hairline (HP:0000294)2.00157037
73Abnormality of the labia majora (HP:0012881)1.99887785
74Myelodysplasia (HP:0002863)1.99731704
75Bladder carcinoma (HP:0002862)1.98935461
76Bladder neoplasm (HP:0009725)1.98935461
77Neoplasm of the adrenal cortex (HP:0100641)1.98051806
78Uterine leiomyosarcoma (HP:0002891)1.96553273
79Leiomyosarcoma (HP:0100243)1.96553273
80Increased number of teeth (HP:0011069)1.96504640
81Protruding tongue (HP:0010808)1.96054280
82Patellar aplasia (HP:0006443)1.95313995
83Ependymoma (HP:0002888)1.94139231
84Renal cortical cysts (HP:0000803)1.93770185
85Abnormality of DNA repair (HP:0003254)1.93141607
86Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.91346655
87Bone marrow hypocellularity (HP:0005528)1.91046241
88Acute myeloid leukemia (HP:0004808)1.89827674
89Pendular nystagmus (HP:0012043)1.89776385
90Abnormality of the duodenum (HP:0002246)1.87550127
91Relative macrocephaly (HP:0004482)1.87548674
92Fetal akinesia sequence (HP:0001989)1.87492973
93Amniotic constriction ring (HP:0009775)1.85995846
94Abnormality of placental membranes (HP:0011409)1.85995846
95Spondylolisthesis (HP:0003302)1.85638514
96Renovascular hypertension (HP:0100817)1.84511824
97Deviation of the thumb (HP:0009603)1.84499002
98Biliary tract neoplasm (HP:0100574)1.84425294
99Reticulocytopenia (HP:0001896)1.84307356
100Optic neuritis (HP:0100653)1.82249229
101Retrobulbar optic neuritis (HP:0100654)1.82249229
102Progressive external ophthalmoplegia (HP:0000590)1.80129043
103Deep palmar crease (HP:0006191)1.79913958
104Lymphoma (HP:0002665)1.79629929
105Abnormality of the columella (HP:0009929)1.79397646
106Ankyloglossia (HP:0010296)1.79378944
107Deep philtrum (HP:0002002)1.78899564
108Neoplasm of the oral cavity (HP:0100649)1.78302328
109Muscle fiber atrophy (HP:0100295)1.78141238
110Aplasia/Hypoplasia of the patella (HP:0006498)1.77827748
111Large earlobe (HP:0009748)1.77299133
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76833884
113IgM deficiency (HP:0002850)1.75744865
114Subaortic stenosis (HP:0001682)1.75380513
115Abnormality of the left ventricular outflow tract (HP:0011103)1.75380513
116White forelock (HP:0002211)1.75254207
117Granulocytopenia (HP:0001913)1.74894816
118Arteriovenous malformation (HP:0100026)1.74633939
119Insidious onset (HP:0003587)1.74370222
120Termporal pattern (HP:0011008)1.74370222
121Hypoplastic labia majora (HP:0000059)1.74269066
122Neoplasm of the small intestine (HP:0100833)1.73969743
123Skull defect (HP:0001362)1.72075149
124Pancreatic islet-cell hyperplasia (HP:0004510)1.71917165
125Abnormal foot bone ossification (HP:0010675)1.71887285
126Attenuation of retinal blood vessels (HP:0007843)1.71784051
127Chin dimple (HP:0010751)1.70658837
128Choanal atresia (HP:0000453)1.70396100
129Anal stenosis (HP:0002025)1.69845346
130Missing ribs (HP:0000921)1.69735951
131Abnormality of T cell number (HP:0011839)1.68704409
132Hypoplasia of the maxilla (HP:0000327)1.68169667
133Embryonal neoplasm (HP:0002898)1.68015605
134Lymphopenia (HP:0001888)1.67908801
135Thyroiditis (HP:0100646)1.67726007
136Breast carcinoma (HP:0003002)1.67611979
137Blepharitis (HP:0000498)1.67458471
138Proximal placement of thumb (HP:0009623)1.67139282
139Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66649514
140Abnormality of the nasal septum (HP:0000419)1.66362136
141Aqueductal stenosis (HP:0002410)1.65275124
142Absent radius (HP:0003974)1.64627754
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.64183403
144Submucous cleft hard palate (HP:0000176)1.64129702
145T lymphocytopenia (HP:0005403)1.64090382
146Basal cell carcinoma (HP:0002671)1.63686943
147Prostate neoplasm (HP:0100787)1.63025141
148Abnormal number of erythroid precursors (HP:0012131)1.61471697
149Heterotopia (HP:0002282)1.61237067
150Small intestinal stenosis (HP:0012848)1.60217988
151Duodenal stenosis (HP:0100867)1.60217988
152Congenital sensorineural hearing impairment (HP:0008527)1.59750124
153Oligodactyly (hands) (HP:0001180)1.59451929
154Abnormality of the phalanges of the 2nd finger (HP:0009541)1.59397976
155Sparse scalp hair (HP:0002209)1.58730122
156Tubulointerstitial nephritis (HP:0001970)1.58286086
157IgG deficiency (HP:0004315)1.57814568
158Medulloblastoma (HP:0002885)1.56411778
159Aplasia involving forearm bones (HP:0009822)1.55653253
160Absent forearm bone (HP:0003953)1.55653253
161Absent eyebrow (HP:0002223)1.55242955
162Metaphyseal dysplasia (HP:0100255)1.55158544
163Increased nuchal translucency (HP:0010880)1.54928791
164Prominent nose (HP:0000448)1.53383667
165Absent thumb (HP:0009777)1.53216933
166Triphalangeal thumb (HP:0001199)1.52690197
167Osteomalacia (HP:0002749)1.52411742
168Abnormality of T cells (HP:0002843)1.52408776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.07277884
2MKNK14.34046958
3MAP3K133.01032988
4BRSK22.89471857
5PLK42.72200851
6SRPK12.67248721
7CDK122.55870951
8PBK2.54123594
9MAP3K142.50250701
10CDK92.27860989
11ZAK2.23175635
12IRAK42.22675644
13PNCK2.15928420
14TXK2.11737056
15MAP3K102.00896630
16EEF2K1.90859189
17CDC71.86934056
18EIF2AK11.75977431
19CAMK1G1.74787515
20FRK1.74412600
21INSRR1.61409062
22TEC1.57678728
23IRAK31.57061404
24ATR1.53330981
25AKT31.52641881
26STK38L1.50822261
27TLK11.49475217
28TIE11.48999944
29FGFR11.48793524
30TNIK1.48282176
31NEK91.45905580
32STK31.45327525
33TAF11.39089224
34PLK31.32275311
35CAMK1D1.28322871
36TSSK61.23519677
37NEK61.22480809
38STK241.21360244
39MST41.11415224
40VRK11.10380631
41IKBKB1.09711957
42* BRD41.09429723
43EIF2AK21.07992620
44CHUK1.07273308
45SCYL21.06075659
46CDK71.04063780
47STK391.02568266
48DYRK31.02156765
49STK161.02039575
50FGFR31.01513877
51SIK30.99934676
52NEK10.96720447
53GRK10.96445059
54ERBB40.95491851
55RPS6KB20.94674142
56* PLK10.94302640
57SGK20.92658130
58CHEK10.90738811
59WEE10.89362990
60BUB10.87679594
61CHEK20.85743027
62CDK30.85630209
63ALK0.85236925
64YES10.84767853
65MAP4K10.83223717
66RPS6KA40.83125418
67PIK3CG0.81148684
68BRSK10.80961870
69NUAK10.80653916
70ATM0.80483411
71KSR10.80004400
72CLK10.79932515
73RPS6KB10.78959302
74NME20.78591945
75AURKB0.78342296
76TTK0.72756195
77RPS6KA50.72208284
78NLK0.72091878
79MARK30.71903694
80CDK80.70688675
81NEK20.70359267
82TRIM280.70072385
83MTOR0.69966977
84EIF2AK30.69966562
85TAOK20.69373576
86CSNK1A1L0.68958606
87BCR0.68614288
88MAPK70.67976798
89STK40.67179309
90PASK0.66069951
91ITK0.63501739
92BMPR20.63084361
93DYRK1A0.62495374
94MELK0.61002677
95KSR20.60591001
96CASK0.60051061
97EPHA20.59900970
98PLK20.59638335
99PRPF4B0.58541012
100RAF10.57798853
101MAP3K20.57311808
102LATS20.56999268
103BMPR1B0.56505522
104CDK20.55484908
105TGFBR10.55307917
106MST1R0.55086197
107EPHB20.54471399
108CDK40.54184547
109PIM10.54160512
110SGK30.53957225
111FGFR20.51983761
112BTK0.51226980
113WNK10.50660402
114CDK10.49933873
115MAPK90.49126458
116ACVR1B0.48966657
117IRAK10.48872253
118RPS6KA10.47861055
119CDK60.46490085
120EPHA30.45071272
121LCK0.45001120
122STK100.44696196
123IRAK20.44570636
124MAP3K120.43756498
125LATS10.43725388
126LYN0.43682550
127PKN20.43242737
128MAPK140.43020836
129JAK30.42398807
130MAPK100.42095081
131ICK0.40616209
132PRKCQ0.40171699
133CSNK1G10.39781355
134ERBB30.39436209
135HIPK20.39404664
136MAP3K90.39219546
137PDGFRB0.39181719
138MAPK130.38383419
139DYRK20.38117189
140CAMK2D0.37367386
141GSK3B0.37125666
142CCNB10.36014063
143SYK0.35181709

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.60695655
2RNA polymerase_Homo sapiens_hsa030202.91194058
3Fanconi anemia pathway_Homo sapiens_hsa034602.57848371
4DNA replication_Homo sapiens_hsa030302.48207723
5Homologous recombination_Homo sapiens_hsa034402.41081693
6Base excision repair_Homo sapiens_hsa034102.35013046
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30144171
8Spliceosome_Homo sapiens_hsa030402.18726110
9Mismatch repair_Homo sapiens_hsa034302.18339787
10Non-homologous end-joining_Homo sapiens_hsa034501.87735827
11Basal transcription factors_Homo sapiens_hsa030221.81678625
12Thyroid cancer_Homo sapiens_hsa052161.81380098
13Cell cycle_Homo sapiens_hsa041101.72854293
14Primary immunodeficiency_Homo sapiens_hsa053401.70251001
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.58207481
16RNA transport_Homo sapiens_hsa030131.57500026
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49792793
18Adherens junction_Homo sapiens_hsa045201.48940276
19p53 signaling pathway_Homo sapiens_hsa041151.45870583
20mRNA surveillance pathway_Homo sapiens_hsa030151.44451462
21RNA degradation_Homo sapiens_hsa030181.43496053
22Phototransduction_Homo sapiens_hsa047441.43438156
23Nucleotide excision repair_Homo sapiens_hsa034201.43214121
24Endometrial cancer_Homo sapiens_hsa052131.41634967
25Pyrimidine metabolism_Homo sapiens_hsa002401.40966936
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37744376
27One carbon pool by folate_Homo sapiens_hsa006701.36852387
28Hematopoietic cell lineage_Homo sapiens_hsa046401.31946883
29Herpes simplex infection_Homo sapiens_hsa051681.29034726
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26322654
31Measles_Homo sapiens_hsa051621.25914552
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25129729
33Epstein-Barr virus infection_Homo sapiens_hsa051691.23095144
34Selenocompound metabolism_Homo sapiens_hsa004501.22893061
35Inositol phosphate metabolism_Homo sapiens_hsa005621.20029469
36Ribosome_Homo sapiens_hsa030101.19125341
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16803220
38Graft-versus-host disease_Homo sapiens_hsa053321.15489090
39Allograft rejection_Homo sapiens_hsa053301.15246651
40Renal cell carcinoma_Homo sapiens_hsa052111.10734499
41Systemic lupus erythematosus_Homo sapiens_hsa053221.10462907
42* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06855663
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06407375
44mTOR signaling pathway_Homo sapiens_hsa041501.05325145
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04760896
46T cell receptor signaling pathway_Homo sapiens_hsa046601.04709660
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02468919
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00399484
49Glioma_Homo sapiens_hsa052140.97346021
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96835288
51MicroRNAs in cancer_Homo sapiens_hsa052060.95851186
52Dorso-ventral axis formation_Homo sapiens_hsa043200.95707280
53HTLV-I infection_Homo sapiens_hsa051660.95230082
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94205685
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94040029
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93883538
57Small cell lung cancer_Homo sapiens_hsa052220.93625463
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91347412
59B cell receptor signaling pathway_Homo sapiens_hsa046620.91291823
60Purine metabolism_Homo sapiens_hsa002300.90961827
61Hepatitis B_Homo sapiens_hsa051610.90155005
62Proteoglycans in cancer_Homo sapiens_hsa052050.88652517
63Prolactin signaling pathway_Homo sapiens_hsa049170.84748941
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.84150475
65Fatty acid biosynthesis_Homo sapiens_hsa000610.83567287
66Viral carcinogenesis_Homo sapiens_hsa052030.80618313
67Autoimmune thyroid disease_Homo sapiens_hsa053200.80403957
68Wnt signaling pathway_Homo sapiens_hsa043100.79457824
69Hedgehog signaling pathway_Homo sapiens_hsa043400.79410467
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78874254
71Leishmaniasis_Homo sapiens_hsa051400.78833023
72Bladder cancer_Homo sapiens_hsa052190.77992157
73Type I diabetes mellitus_Homo sapiens_hsa049400.74120088
74Prostate cancer_Homo sapiens_hsa052150.72176977
75Osteoclast differentiation_Homo sapiens_hsa043800.70806735
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70278203
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69454826
78Hippo signaling pathway_Homo sapiens_hsa043900.69381270
79TNF signaling pathway_Homo sapiens_hsa046680.68712860
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68497795
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67141999
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.65699167
83FoxO signaling pathway_Homo sapiens_hsa040680.64871431
84Legionellosis_Homo sapiens_hsa051340.62636696
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62561815
86Olfactory transduction_Homo sapiens_hsa047400.61082303
87Choline metabolism in cancer_Homo sapiens_hsa052310.60982733
88Acute myeloid leukemia_Homo sapiens_hsa052210.60383747
89Influenza A_Homo sapiens_hsa051640.60181131
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60064047
91Antigen processing and presentation_Homo sapiens_hsa046120.56185112
92Circadian rhythm_Homo sapiens_hsa047100.54140136
93Chronic myeloid leukemia_Homo sapiens_hsa052200.52944853
94Asthma_Homo sapiens_hsa053100.52460932
95Alcoholism_Homo sapiens_hsa050340.51863303
96Pancreatic cancer_Homo sapiens_hsa052120.51240470
97Insulin signaling pathway_Homo sapiens_hsa049100.49926845
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.48703210
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48635758
100Insulin resistance_Homo sapiens_hsa049310.47986960
101HIF-1 signaling pathway_Homo sapiens_hsa040660.47937051
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47827097
103Long-term depression_Homo sapiens_hsa047300.47292031
104Hepatitis C_Homo sapiens_hsa051600.47172014
105Type II diabetes mellitus_Homo sapiens_hsa049300.46232928
106Apoptosis_Homo sapiens_hsa042100.46158111
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45915867
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45672682
109Toxoplasmosis_Homo sapiens_hsa051450.45508715
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45369622
111Pathways in cancer_Homo sapiens_hsa052000.45185294
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44167547
113Oocyte meiosis_Homo sapiens_hsa041140.43456370
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.42055811
115Basal cell carcinoma_Homo sapiens_hsa052170.41996637
116MAPK signaling pathway_Homo sapiens_hsa040100.41711920
117Non-small cell lung cancer_Homo sapiens_hsa052230.41513245
118Estrogen signaling pathway_Homo sapiens_hsa049150.40494820
119Chemokine signaling pathway_Homo sapiens_hsa040620.36934465
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36806986
121VEGF signaling pathway_Homo sapiens_hsa043700.36342234
122Notch signaling pathway_Homo sapiens_hsa043300.35869477
123Lysine degradation_Homo sapiens_hsa003100.35415725
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34973985
125Nicotine addiction_Homo sapiens_hsa050330.34136119
126Amphetamine addiction_Homo sapiens_hsa050310.33592607
127Rheumatoid arthritis_Homo sapiens_hsa053230.33248947
128Colorectal cancer_Homo sapiens_hsa052100.32801430
129Viral myocarditis_Homo sapiens_hsa054160.31932678
130TGF-beta signaling pathway_Homo sapiens_hsa043500.31726157
131ErbB signaling pathway_Homo sapiens_hsa040120.31711805
132Melanoma_Homo sapiens_hsa052180.31106843
133African trypanosomiasis_Homo sapiens_hsa051430.30293671
134Tight junction_Homo sapiens_hsa045300.29966894
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.29952444
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29631830
137AMPK signaling pathway_Homo sapiens_hsa041520.29546676
138Shigellosis_Homo sapiens_hsa051310.29307008

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