CCNT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.61745868
2histone H3-K4 methylation (GO:0051568)4.88273176
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.86858209
4negative regulation of translation, ncRNA-mediated (GO:0040033)4.86858209
5regulation of translation, ncRNA-mediated (GO:0045974)4.86858209
6peptidyl-lysine trimethylation (GO:0018023)4.46269481
7neural tube formation (GO:0001841)4.40805413
8positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.27509373
9mRNA splice site selection (GO:0006376)4.21367124
10establishment of protein localization to Golgi (GO:0072600)3.86856294
11pre-miRNA processing (GO:0031054)3.82579461
12histone lysine methylation (GO:0034968)3.69201164
13protein K11-linked deubiquitination (GO:0035871)3.68268775
14negative regulation of histone methylation (GO:0031061)3.67220844
15mitotic sister chromatid cohesion (GO:0007064)3.62855058
16protein targeting to Golgi (GO:0000042)3.62726561
17histone H3-K36 demethylation (GO:0070544)3.50979889
18interkinetic nuclear migration (GO:0022027)3.46678347
19positive regulation of mRNA processing (GO:0050685)3.45597629
20peptidyl-lysine methylation (GO:0018022)3.36773719
21histone H3-K9 methylation (GO:0051567)3.36571907
22attachment of spindle microtubules to kinetochore (GO:0008608)3.27935201
23regulation of histone H3-K27 methylation (GO:0061085)3.25500103
24histone H4-K8 acetylation (GO:0043982)3.23191837
25histone H4-K5 acetylation (GO:0043981)3.23191837
26cerebellar Purkinje cell differentiation (GO:0021702)3.21610644
27DNA double-strand break processing (GO:0000729)3.20973278
28somite rostral/caudal axis specification (GO:0032525)3.20033853
29positive regulation of histone H3-K4 methylation (GO:0051571)3.12021162
30neuronal ion channel clustering (GO:0045161)3.10579030
31establishment of nucleus localization (GO:0040023)3.09573345
32histone H3-K9 demethylation (GO:0033169)3.09163251
33histone H4-K16 acetylation (GO:0043984)3.08366855
34negative regulation of DNA recombination (GO:0045910)3.08318359
35regulation of DNA endoreduplication (GO:0032875)3.08115737
36pore complex assembly (GO:0046931)3.08092275
37positive regulation of mRNA metabolic process (GO:1903313)3.08056621
38histone methylation (GO:0016571)3.07976039
39stress granule assembly (GO:0034063)3.07723964
40nucleus localization (GO:0051647)3.06016803
41nuclear pore complex assembly (GO:0051292)3.05880810
42pyrimidine nucleobase catabolic process (GO:0006208)3.05425454
43positive regulation of mRNA 3-end processing (GO:0031442)3.04968288
44presynaptic membrane assembly (GO:0097105)3.00879726
45regulation of mRNA 3-end processing (GO:0031440)3.00478528
46regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.99394673
47positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.99394673
48cytoplasmic mRNA processing body assembly (GO:0033962)2.97979853
49regulation of mitotic spindle checkpoint (GO:1903504)2.94989028
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94989028
51regulation of telomere maintenance (GO:0032204)2.93172868
52DNA demethylation (GO:0080111)2.92548668
53central nervous system projection neuron axonogenesis (GO:0021952)2.91587954
54regulation of histone H3-K4 methylation (GO:0051569)2.91481872
55positive regulation of developmental pigmentation (GO:0048087)2.91118603
56cellular response to ethanol (GO:0071361)2.87889132
57regulation of mRNA splicing, via spliceosome (GO:0048024)2.85865006
58histone H3-K9 modification (GO:0061647)2.85532436
59nuclear pore organization (GO:0006999)2.84822582
60ionotropic glutamate receptor signaling pathway (GO:0035235)2.82536760
61rRNA catabolic process (GO:0016075)2.82535131
62locomotory exploration behavior (GO:0035641)2.81839755
63regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81015471
64acrosome assembly (GO:0001675)2.77781065
65regulation of RNA splicing (GO:0043484)2.76958915
66regulation of histone methylation (GO:0031060)2.76895595
67regulation of chromatin silencing (GO:0031935)2.75961853
68axonal fasciculation (GO:0007413)2.75697785
69positive regulation of cell cycle checkpoint (GO:1901978)2.75456959
70regulation of pigment cell differentiation (GO:0050932)2.74798972
71neuronal stem cell maintenance (GO:0097150)2.69845227
72negative regulation of neurotransmitter secretion (GO:0046929)2.69026682
73negative regulation of NF-kappaB import into nucleus (GO:0042347)2.67935328
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67488178
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.67409090
76olfactory bulb development (GO:0021772)2.66854816
77histone lysine demethylation (GO:0070076)2.66666927
78sister chromatid cohesion (GO:0007062)2.65729150
79head development (GO:0060322)2.64640308
80presynaptic membrane organization (GO:0097090)2.64580956
81negative regulation of dendrite development (GO:2000171)2.62866404
82regulation of sister chromatid cohesion (GO:0007063)2.62210743
83regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.61925976
84peptidyl-threonine dephosphorylation (GO:0035970)2.61709469
85regulation of growth hormone secretion (GO:0060123)2.61186312
86positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.60773629
87regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.60773629
88activated T cell proliferation (GO:0050798)2.59715109
89cerebral cortex radially oriented cell migration (GO:0021799)2.59103935
90ncRNA catabolic process (GO:0034661)2.58214091
91intraciliary transport (GO:0042073)2.58022663
92response to pheromone (GO:0019236)2.57283265
93gastrulation with mouth forming second (GO:0001702)2.57035591
94nerve growth factor signaling pathway (GO:0038180)2.55953860
95protein deubiquitination (GO:0016579)2.52946054
96regulation of Rac protein signal transduction (GO:0035020)2.51620520
97protein K48-linked deubiquitination (GO:0071108)2.51499004
98DNA integration (GO:0015074)2.50923246
99regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.50828291
100synaptic transmission, glutamatergic (GO:0035249)2.50748451
101regulation of centriole replication (GO:0046599)2.50717889
102histone demethylation (GO:0016577)2.50449557
103neuron recognition (GO:0008038)2.49959822
104protein localization to Golgi apparatus (GO:0034067)2.49672362
105glutamate receptor signaling pathway (GO:0007215)2.48449503
106negative regulation of cell killing (GO:0031342)2.48446950
107negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48446950
108negative regulation of neurotransmitter transport (GO:0051589)2.48254395
109regulation of mRNA processing (GO:0050684)2.48047772
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47987564
111positive regulation of histone methylation (GO:0031062)2.47239895
112histone deubiquitination (GO:0016578)2.47208234
113positive regulation of mRNA catabolic process (GO:0061014)2.46644380
114histone mRNA catabolic process (GO:0071044)2.45986547
115positive regulation of gene expression, epigenetic (GO:0045815)2.44250290
116negative regulation of fibroblast apoptotic process (GO:2000270)2.43817023
117phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42744623
118dorsal/ventral axis specification (GO:0009950)2.42618132
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42132494
120protein prenylation (GO:0018342)2.41761340
121prenylation (GO:0097354)2.41761340
122DNA topological change (GO:0006265)2.39550449
123regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38359792
124neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.38156898
125dosage compensation (GO:0007549)2.37211634
126regulation of mRNA metabolic process (GO:1903311)2.35564223
127negative regulation of DNA-dependent DNA replication (GO:2000104)2.32279101
128regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31800593
129regulation of histone H3-K9 methylation (GO:0051570)2.31426383
130synaptic vesicle endocytosis (GO:0048488)2.30861169
131negative regulation of chromatin modification (GO:1903309)2.28934583
132protein demethylation (GO:0006482)2.28387226
133protein dealkylation (GO:0008214)2.28387226
134neural tube development (GO:0021915)2.26865878
135transmission of nerve impulse (GO:0019226)2.26424547
136snRNA transcription (GO:0009301)2.25992169
137forebrain neuron differentiation (GO:0021879)2.25466739
138negative regulation of histone modification (GO:0031057)2.25358936
139histone H4 acetylation (GO:0043967)2.25023119
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.24610962
141regulation of protein polyubiquitination (GO:1902914)2.24150480
142cell differentiation in hindbrain (GO:0021533)2.22733476
143monoubiquitinated protein deubiquitination (GO:0035520)2.22087239
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21494645
145regulation of RNA export from nucleus (GO:0046831)2.21194020
146protein methylation (GO:0006479)2.20819666
147protein alkylation (GO:0008213)2.20819666
148regulation of postsynaptic membrane potential (GO:0060078)2.18660881
149DNA dealkylation (GO:0035510)2.15731633
150negative regulation of mRNA processing (GO:0050686)2.15293884
151dendritic spine morphogenesis (GO:0060997)2.15176442
152poly(A)+ mRNA export from nucleus (GO:0016973)2.14219832
153centrosome duplication (GO:0051298)2.14211197
154positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.14026299
155microtubule anchoring (GO:0034453)2.13392372
156retrograde transport, vesicle recycling within Golgi (GO:0000301)2.13264731
157negative regulation of mRNA metabolic process (GO:1903312)2.12907850
158regulation of helicase activity (GO:0051095)2.12040837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.75995116
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.72333291
3E2F7_22180533_ChIP-Seq_HELA_Human3.46615904
4GBX2_23144817_ChIP-Seq_PC3_Human3.17084930
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84501001
6EZH2_22144423_ChIP-Seq_EOC_Human2.76935177
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.62116638
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.42952951
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28755028
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18411230
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15624352
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11507491
13IGF1R_20145208_ChIP-Seq_DFB_Human2.04359065
14TP63_19390658_ChIP-ChIP_HaCaT_Human1.93208188
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90176143
16GATA1_22025678_ChIP-Seq_K562_Human1.89002428
17VDR_22108803_ChIP-Seq_LS180_Human1.84186788
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82901681
19FUS_26573619_Chip-Seq_HEK293_Human1.80610438
20DROSHA_22980978_ChIP-Seq_HELA_Human1.79567174
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78923638
22FOXM1_23109430_ChIP-Seq_U2OS_Human1.75158615
23EWS_26573619_Chip-Seq_HEK293_Human1.74672910
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72156289
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71833672
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69293901
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67664048
28TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.64809326
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64036490
30DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63960517
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62117988
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62117988
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61875795
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61598876
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59708089
36TAF15_26573619_Chip-Seq_HEK293_Human1.59494559
37STAT3_23295773_ChIP-Seq_U87_Human1.57015242
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.55879154
39* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53929226
40ER_23166858_ChIP-Seq_MCF-7_Human1.53374158
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.52259957
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.50424016
43* IRF1_19129219_ChIP-ChIP_H3396_Human1.49977187
44SMAD4_21799915_ChIP-Seq_A2780_Human1.49709832
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48993006
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44442237
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43950709
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42468777
49* TCF4_23295773_ChIP-Seq_U87_Human1.40778420
50* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40002127
51REST_21632747_ChIP-Seq_MESCs_Mouse1.39632958
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38080617
53FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37751016
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37428874
55* EZH2_27294783_Chip-Seq_NPCs_Mouse1.37139043
56CBP_20019798_ChIP-Seq_JUKART_Human1.36684973
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36684973
58P300_19829295_ChIP-Seq_ESCs_Human1.34440280
59ELK1_19687146_ChIP-ChIP_HELA_Human1.32046062
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30920484
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30685979
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30405109
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29054391
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29046611
65* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28863282
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28808483
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28136694
68* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27492150
69* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27294807
70* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26902568
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.26312803
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.26118849
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25188581
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24807263
75AR_21572438_ChIP-Seq_LNCaP_Human1.24750126
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24532301
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22399861
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22288693
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22152934
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22103649
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21478823
82CIITA_25753668_ChIP-Seq_RAJI_Human1.21185489
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20392872
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20190342
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.19320224
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19174727
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19124819
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19042361
89TP53_16413492_ChIP-PET_HCT116_Human1.17949815
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.17736490
91* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17716051
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.17538060
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.17476042
94* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17371807
95AHR_22903824_ChIP-Seq_MCF-7_Human1.15015811
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14471028
97AR_25329375_ChIP-Seq_VCAP_Human1.14463278
98* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14183918
99AR_19668381_ChIP-Seq_PC3_Human1.14116971
100RNF2_27304074_Chip-Seq_NSC_Mouse1.12317310
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11753414
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11137540
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10873451
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10489752
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10395995
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10300213
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.10273680
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09236566
109SOX2_16153702_ChIP-ChIP_HESCs_Human1.09234499
110SOX9_26525672_Chip-Seq_HEART_Mouse1.09218362
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09150571
112EZH2_27304074_Chip-Seq_ESCs_Mouse1.08757344
113RUNX2_22187159_ChIP-Seq_PCA_Human1.08584046
114* NFE2_27457419_Chip-Seq_LIVER_Mouse1.08337025
115FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08313716
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.08073566
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07843423
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07138395
119BCAT_22108803_ChIP-Seq_LS180_Human1.06868349
120ISL1_27105846_Chip-Seq_CPCs_Mouse1.06521457
121TCF4_22108803_ChIP-Seq_LS180_Human1.06447276
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05589075
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05422402
124* P300_18555785_Chip-Seq_ESCs_Mouse1.04885409
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04357453
126SALL4_22934838_ChIP-ChIP_CD34+_Human1.04104820
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03975033
128FLI1_27457419_Chip-Seq_LIVER_Mouse1.03276737
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.02385574
130CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01783273
131RNF2_27304074_Chip-Seq_ESCs_Mouse1.00989615
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00837081
133* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00796230
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00273627
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99715735
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.98978463
137SCL_19346495_ChIP-Seq_HPC-7_Human0.97219707
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97029083
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.96375267
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96303641
141* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95776809
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95706688
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95521904
144ZNF274_21170338_ChIP-Seq_K562_Hela0.94908955
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94058768
146RXR_22108803_ChIP-Seq_LS180_Human0.93802013
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93721533
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93125461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.16390786
2MP0003787_abnormal_imprinting4.50435859
3MP0004859_abnormal_synaptic_plasticity3.33775270
4MP0003121_genomic_imprinting2.96811862
5MP0002102_abnormal_ear_morphology2.80260380
6MP0003283_abnormal_digestive_organ2.52907309
7MP0003880_abnormal_central_pattern2.46532906
8MP0006292_abnormal_olfactory_placode2.41930137
9MP0005646_abnormal_pituitary_gland2.08878276
10MP0003122_maternal_imprinting2.04894373
11MP0000778_abnormal_nervous_system2.01872358
12MP0003221_abnormal_cardiomyocyte_apopto1.96812179
13MP0000566_synostosis1.93647688
14MP0008877_abnormal_DNA_methylation1.87541526
15MP0001486_abnormal_startle_reflex1.84897903
16MP0003567_abnormal_fetal_cardiomyocyte1.83417840
17MP0003890_abnormal_embryonic-extraembry1.80940552
18MP0003635_abnormal_synaptic_transmissio1.76566745
19MP0005409_darkened_coat_color1.68142699
20MP0001188_hyperpigmentation1.67851589
21MP0004145_abnormal_muscle_electrophysio1.64567271
22MP0004133_heterotaxia1.64143856
23MP0010094_abnormal_chromosome_stability1.61928450
24MP0003183_abnormal_peptide_metabolism1.56735422
25MP0005174_abnormal_tail_pigmentation1.55994457
26MP0008057_abnormal_DNA_replication1.51283230
27MP0002638_abnormal_pupillary_reflex1.51138450
28MP0008058_abnormal_DNA_repair1.48290257
29MP0005423_abnormal_somatic_nervous1.46612333
30MP0000383_abnormal_hair_follicle1.46454980
31MP0009745_abnormal_behavioral_response1.44912281
32MP0004264_abnormal_extraembryonic_tissu1.44632064
33MP0006072_abnormal_retinal_apoptosis1.42815341
34MP0008961_abnormal_basal_metabolism1.39447477
35MP0002064_seizures1.39200336
36MP0002063_abnormal_learning/memory/cond1.38259130
37MP0005645_abnormal_hypothalamus_physiol1.37278736
38MP0003123_paternal_imprinting1.37232305
39MP0009046_muscle_twitch1.34826647
40MP0004885_abnormal_endolymph1.32258320
41MP0000955_abnormal_spinal_cord1.30529915
42MP0002653_abnormal_ependyma_morphology1.30460846
43MP0010352_gastrointestinal_tract_polyps1.30394866
44MP0005394_taste/olfaction_phenotype1.28730305
45MP0005499_abnormal_olfactory_system1.28730305
46MP0010678_abnormal_skin_adnexa1.26304257
47MP0002938_white_spotting1.24957100
48MP0000427_abnormal_hair_cycle1.24463192
49MP0001286_abnormal_eye_development1.23160037
50MP0003111_abnormal_nucleus_morphology1.19552860
51MP0002557_abnormal_social/conspecific_i1.18579572
52MP0002572_abnormal_emotion/affect_behav1.18178316
53MP0000631_abnormal_neuroendocrine_gland1.17801250
54MP0003172_abnormal_lysosome_physiology1.16921725
55MP0006054_spinal_hemorrhage1.16404339
56MP0001177_atelectasis1.16334170
57MP0003861_abnormal_nervous_system1.16134557
58MP0001485_abnormal_pinna_reflex1.15876185
59MP0001984_abnormal_olfaction1.15746975
60MP0004270_analgesia1.14029482
61MP0003195_calcinosis1.12704015
62MP0003943_abnormal_hepatobiliary_system1.12253708
63MP0000647_abnormal_sebaceous_gland1.11319062
64MP0002184_abnormal_innervation1.11015664
65MP0003119_abnormal_digestive_system1.10368851
66MP0008569_lethality_at_weaning1.09686315
67MP0008789_abnormal_olfactory_epithelium1.08970415
68MP0002067_abnormal_sensory_capabilities1.08782223
69MP0004142_abnormal_muscle_tone1.07136661
70MP0000015_abnormal_ear_pigmentation1.06934090
71MP0004484_altered_response_of1.06305007
72MP0004811_abnormal_neuron_physiology1.05768652
73MP0005386_behavior/neurological_phenoty1.05606506
74MP0004924_abnormal_behavior1.05606506
75MP0009703_decreased_birth_body1.04056818
76MP0002152_abnormal_brain_morphology1.03701023
77MP0002272_abnormal_nervous_system1.03542017
78MP0003656_abnormal_erythrocyte_physiolo1.02259011
79MP0009697_abnormal_copulation1.00977154
80MP0002882_abnormal_neuron_morphology1.00891230
81MP0003632_abnormal_nervous_system1.00205808
82MP0002084_abnormal_developmental_patter0.99967027
83MP0004147_increased_porphyrin_level0.96846809
84MP0003385_abnormal_body_wall0.95907131
85MP0003077_abnormal_cell_cycle0.95865730
86MP0001529_abnormal_vocalization0.95675341
87MP0001502_abnormal_circadian_rhythm0.95541215
88MP0009780_abnormal_chondrocyte_physiolo0.95055726
89MP0001293_anophthalmia0.94794576
90MP0003115_abnormal_respiratory_system0.93593066
91MP0008995_early_reproductive_senescence0.93373906
92MP0002233_abnormal_nose_morphology0.91283960
93MP0003137_abnormal_impulse_conducting0.90789916
94MP0000371_diluted_coat_color0.90105488
95MP0005391_vision/eye_phenotype0.89502294
96MP0002928_abnormal_bile_duct0.89483994
97MP0002009_preneoplasia0.87606741
98MP0005379_endocrine/exocrine_gland_phen0.87379478
99MP0005367_renal/urinary_system_phenotyp0.86523179
100MP0000516_abnormal_urinary_system0.86523179
101MP0002075_abnormal_coat/hair_pigmentati0.86157070
102MP0002138_abnormal_hepatobiliary_system0.86071657
103MP0003935_abnormal_craniofacial_develop0.85851371
104MP0002088_abnormal_embryonic_growth/wei0.85344874
105MP0003984_embryonic_growth_retardation0.83606119
106MP0005187_abnormal_penis_morphology0.83002388
107MP0003937_abnormal_limbs/digits/tail_de0.82721930
108MP0009115_abnormal_fat_cell0.81234748
109MP0004215_abnormal_myocardial_fiber0.81228845
110MP0005075_abnormal_melanosome_morpholog0.80123386
111MP0004197_abnormal_fetal_growth/weight/0.79720438
112MP0003693_abnormal_embryo_hatching0.79646935
113MP0002095_abnormal_skin_pigmentation0.78404322
114MP0001672_abnormal_embryogenesis/_devel0.78188216
115MP0005380_embryogenesis_phenotype0.78188216
116MP0002396_abnormal_hematopoietic_system0.77241985
117MP0003828_pulmonary_edema0.76716896
118MP0002751_abnormal_autonomic_nervous0.76289491
119MP0004808_abnormal_hematopoietic_stem0.76280103
120MP0010770_preweaning_lethality0.76237959
121MP0002082_postnatal_lethality0.76237959
122MP0002909_abnormal_adrenal_gland0.75747589
123MP0005248_abnormal_Harderian_gland0.75392306
124MP0002697_abnormal_eye_size0.74477623
125MP0002081_perinatal_lethality0.73962234
126MP0010769_abnormal_survival0.73885938
127MP0002092_abnormal_eye_morphology0.73392041
128MP0001299_abnormal_eye_distance/0.73119093
129MP0010768_mortality/aging0.72989209
130MP0001697_abnormal_embryo_size0.72645473
131MP0008007_abnormal_cellular_replicative0.72290515
132MP0004742_abnormal_vestibular_system0.72195912
133MP0009672_abnormal_birth_weight0.72183189
134MP0005551_abnormal_eye_electrophysiolog0.71330439
135MP0002085_abnormal_embryonic_tissue0.70917236
136MP0002177_abnormal_outer_ear0.70581223
137MP0005253_abnormal_eye_physiology0.69011011
138MP0001324_abnormal_eye_pigmentation0.68974164
139MP0002114_abnormal_axial_skeleton0.68374488
140MP0003724_increased_susceptibility_to0.68216689
141MP0010307_abnormal_tumor_latency0.68114739
142MP0006276_abnormal_autonomic_nervous0.67954200
143MP0001186_pigmentation_phenotype0.67595173
144MP0000428_abnormal_craniofacial_morphol0.67577778
145MP0005220_abnormal_exocrine_pancreas0.67056456

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.77249019
2Volvulus (HP:0002580)3.05319489
3Thyroid carcinoma (HP:0002890)2.98581015
4Atonic seizures (HP:0010819)2.85865658
5Abnormality of the columella (HP:0009929)2.85528074
6Curly hair (HP:0002212)2.84013834
7Tubulointerstitial nephritis (HP:0001970)2.81590749
8Protruding tongue (HP:0010808)2.80485325
9Neoplasm of the oral cavity (HP:0100649)2.72654814
10Chronic hepatic failure (HP:0100626)2.63296614
11Febrile seizures (HP:0002373)2.57341323
12Broad-based gait (HP:0002136)2.53643899
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53203467
14Obsessive-compulsive behavior (HP:0000722)2.48049565
15Cystic hygroma (HP:0000476)2.47285493
16Long eyelashes (HP:0000527)2.44462572
17Ectopic kidney (HP:0000086)2.39119232
18Cupped ear (HP:0000378)2.36708877
19Anal stenosis (HP:0002025)2.35807336
20Stomach cancer (HP:0012126)2.33680496
21Colon cancer (HP:0003003)2.33333650
22Abnormality of the labia minora (HP:0012880)2.32898365
23Abnormality of DNA repair (HP:0003254)2.28023715
24Amyotrophic lateral sclerosis (HP:0007354)2.27699857
25Ependymoma (HP:0002888)2.24848946
26Chromsome breakage (HP:0040012)2.24134780
27Embryonal renal neoplasm (HP:0011794)2.22327744
28Midline defect of the nose (HP:0004122)2.21234523
29Absent speech (HP:0001344)2.19877929
30Hypoplastic ischia (HP:0003175)2.19617642
31Lip pit (HP:0100267)2.18580127
32Neoplasm of the tracheobronchial system (HP:0100552)2.17121203
33Bladder carcinoma (HP:0002862)2.16965390
34Bladder neoplasm (HP:0009725)2.16965390
35Fair hair (HP:0002286)2.14827613
36High anterior hairline (HP:0009890)2.14025028
37Hypoplastic labia majora (HP:0000059)2.12987300
38Renal cortical cysts (HP:0000803)2.12852373
39Focal motor seizures (HP:0011153)2.12761546
40Abnormality of chromosome stability (HP:0003220)2.10765220
41Abnormality of macular pigmentation (HP:0008002)2.10081021
42Papillary thyroid carcinoma (HP:0002895)2.08757425
43Macroorchidism (HP:0000053)2.08377037
44Tented upper lip vermilion (HP:0010804)2.07157080
45Epileptic encephalopathy (HP:0200134)2.06290766
46Intestinal atresia (HP:0011100)2.04822262
47Drooling (HP:0002307)2.04545467
48Excessive salivation (HP:0003781)2.04545467
49Generalized hypopigmentation of hair (HP:0011358)2.04391779
50Trigonocephaly (HP:0000243)2.04167439
51Cortical dysplasia (HP:0002539)2.03654944
52Abnormality of the right ventricle (HP:0001707)2.02141394
53Gaze-evoked nystagmus (HP:0000640)2.01794423
54Oligodactyly (hands) (HP:0001180)2.01684529
55Nephronophthisis (HP:0000090)2.01417402
56Exotropia (HP:0000577)2.00847668
57Aqueductal stenosis (HP:0002410)2.00307648
58Abnormality of the renal cortex (HP:0011035)1.99562163
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99226087
60Short 4th metacarpal (HP:0010044)1.99226087
61Medulloblastoma (HP:0002885)1.98990548
62Narrow palate (HP:0000189)1.97880737
63Pancreatic cysts (HP:0001737)1.97650849
64Abnormality of the renal medulla (HP:0100957)1.97429225
65Abnormal hair whorl (HP:0010721)1.96926630
66Depressed nasal tip (HP:0000437)1.95465815
67Abnormality of the astrocytes (HP:0100707)1.93932864
68Astrocytoma (HP:0009592)1.93932864
69Medial flaring of the eyebrow (HP:0010747)1.93630968
70Rhabdomyosarcoma (HP:0002859)1.92253478
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87322673
72Supernumerary ribs (HP:0005815)1.86994584
73Skull defect (HP:0001362)1.86363795
74Truncal obesity (HP:0001956)1.85790083
75Abnormality of the labia majora (HP:0012881)1.84883126
76Supernumerary spleens (HP:0009799)1.84471059
77Pancreatic fibrosis (HP:0100732)1.84166174
78Hypoplasia of the maxilla (HP:0000327)1.83203537
79Heterotopia (HP:0002282)1.83055792
80True hermaphroditism (HP:0010459)1.82843506
81Hypochromic microcytic anemia (HP:0004840)1.82768199
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.82722773
83Abnormality of the ischium (HP:0003174)1.82683657
84Congenital stationary night blindness (HP:0007642)1.81827809
85Biliary tract neoplasm (HP:0100574)1.81229209
86Focal seizures (HP:0007359)1.80421103
87Gonadotropin excess (HP:0000837)1.80271936
88Malignant gastrointestinal tract tumors (HP:0006749)1.80232940
89Gastrointestinal carcinoma (HP:0002672)1.80232940
90Glioma (HP:0009733)1.78496263
91Gastroesophageal reflux (HP:0002020)1.78351638
92Nephroblastoma (Wilms tumor) (HP:0002667)1.77970066
93Genetic anticipation (HP:0003743)1.77759465
94Genital tract atresia (HP:0001827)1.77735144
95Smooth philtrum (HP:0000319)1.76344799
96Alveolar cell carcinoma (HP:0006519)1.76284557
97Neoplasm of the small intestine (HP:0100833)1.76080941
98Papilledema (HP:0001085)1.75534705
99Abnormality of chromosome segregation (HP:0002916)1.75388143
100Breast carcinoma (HP:0003002)1.75174559
101Gait imbalance (HP:0002141)1.75001819
102Central scotoma (HP:0000603)1.74172782
103Vaginal atresia (HP:0000148)1.73074327
104Labial hypoplasia (HP:0000066)1.72336810
105Severe combined immunodeficiency (HP:0004430)1.71621629
106Deeply set eye (HP:0000490)1.71561732
107Abnormality of midbrain morphology (HP:0002418)1.71460140
108Molar tooth sign on MRI (HP:0002419)1.71460140
109Scanning speech (HP:0002168)1.71076292
110Large earlobe (HP:0009748)1.70537762
111Poor coordination (HP:0002370)1.70104744
112Congenital primary aphakia (HP:0007707)1.70094189
113Impaired smooth pursuit (HP:0007772)1.70043830
114Acute lymphatic leukemia (HP:0006721)1.69924982
115Thyroid-stimulating hormone excess (HP:0002925)1.69073368
116Nephrogenic diabetes insipidus (HP:0009806)1.67956092
117Leiomyosarcoma (HP:0100243)1.67625700
118Uterine leiomyosarcoma (HP:0002891)1.67625700
119Abnormal lung lobation (HP:0002101)1.67512211
120Hepatoblastoma (HP:0002884)1.67322256
121Widely spaced teeth (HP:0000687)1.66517332
122Abnormal pancreas size (HP:0012094)1.66026877
123Long nose (HP:0003189)1.64903909
124Inappropriate behavior (HP:0000719)1.64856839
125Acute myeloid leukemia (HP:0004808)1.64737508
126Retrobulbar optic neuritis (HP:0100654)1.63727440
127Optic neuritis (HP:0100653)1.63727440
128Dyskinesia (HP:0100660)1.63563101
129Bile duct proliferation (HP:0001408)1.62581880
130Abnormal biliary tract physiology (HP:0012439)1.62581880
131Supernumerary bones of the axial skeleton (HP:0009144)1.62298468
132Progressive inability to walk (HP:0002505)1.62089851
133Abnormality of the carotid arteries (HP:0005344)1.61617997
134Hyperventilation (HP:0002883)1.61250611
135Tubulointerstitial abnormality (HP:0001969)1.61075283
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60402890
137Mask-like facies (HP:0000298)1.60316138
138Attention deficit hyperactivity disorder (HP:0007018)1.60267520
139Autism (HP:0000717)1.60160474
140Abnormality of the metopic suture (HP:0005556)1.60074046
141Absent eyebrow (HP:0002223)1.60041612
142Elfin facies (HP:0004428)1.60039075
143Postaxial foot polydactyly (HP:0001830)1.59821105
144Embryonal neoplasm (HP:0002898)1.59471836
145Broad thumb (HP:0011304)1.59366927
146Decreased lacrimation (HP:0000633)1.59257853
147Hypoplastic iliac wings (HP:0002866)1.59204531
148Transitional cell carcinoma of the bladder (HP:0006740)1.58985281
149Sloping forehead (HP:0000340)1.58175137
150Lissencephaly (HP:0001339)1.58171536
151Prominent nose (HP:0000448)1.58027637
152Truncal ataxia (HP:0002078)1.56991289
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.55181347
154Thick eyebrow (HP:0000574)1.55180925
155Visual hallucinations (HP:0002367)1.54794777
156Occipital encephalocele (HP:0002085)1.54484229
157Sandal gap (HP:0001852)1.54402791
158Thyroiditis (HP:0100646)1.53679867
159Highly arched eyebrow (HP:0002553)1.52891955
160Hyperacusis (HP:0010780)1.52887516
161Abnormality of the diencephalon (HP:0010662)1.52881616
162Hip dysplasia (HP:0001385)1.52863542
163Cutaneous finger syndactyly (HP:0010554)1.52731210
164Narrow forehead (HP:0000341)1.52623484
165Tapered finger (HP:0001182)1.52553529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.20041844
2ACVR1B2.89926867
3CDK122.85266968
4FRK2.82053735
5KSR12.54912586
6SRPK12.49132638
7INSRR2.47824379
8LATS12.44949661
9BRSK22.42512891
10EIF2AK32.02826517
11CDK192.02810882
12EPHA41.95578504
13EPHA31.94387986
14TNIK1.81806015
15TRIM281.73136139
16FGFR21.63429355
17SIK31.62764835
18SGK21.61785093
19MKNK21.58015839
20CDC71.57370183
21YES11.55375134
22AKT31.48428940
23MAP3K131.47444933
24STK38L1.43821368
25PLK41.40736022
26NLK1.40502187
27PRKD21.40258691
28CASK1.38535199
29SIK21.36977894
30NTRK21.36400870
31* BRD41.34632628
32SGK31.33601382
33CAMK1G1.32642040
34WNK11.32181644
35CDC42BPA1.32035823
36CAMKK21.29190230
37ERBB31.26756975
38PRPF4B1.24095213
39MAP3K41.23703936
40BCR1.19856217
41NUAK11.17856213
42OXSR11.17232178
43PNCK1.16573216
44NEK61.15915463
45CDK31.15474346
46RPS6KA41.15394757
47MUSK1.14710890
48MAPK131.14046405
49SGK11.12588116
50DYRK31.12137453
51BMPR1B1.09041072
52UHMK11.08912825
53MKNK11.07634125
54PLK21.06879767
55ATR1.04297400
56DYRK1A1.02544863
57WNK31.02365672
58FGFR31.01773339
59CSNK1A1L1.01402253
60SGK4940.99399733
61SGK2230.99399733
62MARK20.96751457
63MAP3K20.96177788
64MAP2K40.95169286
65CHEK20.94905126
66WEE10.92484919
67HIPK20.92254546
68PAK30.90607028
69CHEK10.86446089
70MST40.85431871
71STK390.83212220
72MAPK100.82563218
73MAP2K70.82476624
74MELK0.81920463
75ERBB20.79531044
76ATM0.79032201
77ZAK0.75399220
78CAMK1D0.74164329
79CDK90.74145113
80CSNK1G20.71855715
81MARK10.69960996
82CSNK1G30.68568273
83MAPK70.68313148
84FGR0.68230156
85GSK3B0.66372538
86MAP3K60.66262566
87MAP3K70.66216322
88MAP3K140.65445456
89MAP3K90.64420112
90PRKCH0.63630196
91* CDK10.63509929
92BLK0.62546326
93MAP3K100.62256652
94PRKDC0.62182090
95NEK20.61698832
96CSNK1D0.61509516
97MAPK140.61444761
98CAMK40.60698684
99STK240.60122933
100MTOR0.59950388
101RPS6KA30.58339427
102CDK60.58235497
103CDK20.58043714
104DYRK1B0.57896608
105AKT10.55879876
106IRAK20.55834689
107TNK20.55440540
108FGFR10.54950501
109PLK30.54062312
110TTK0.53244894
111IRAK10.52488655
112ADRBK20.51331666
113PRKAA10.51269442
114PIK3CA0.51214414
115STK110.50873981
116MATK0.50425261
117PINK10.49609709
118EGFR0.48636738
119MAPK150.48384102
120MAP3K50.47811889
121RET0.47675028
122AKT20.47523265
123PRKG10.46170470
124PASK0.46164166
125TAF10.45968101
126BMPR20.45654856
127STK30.45255618
128TEC0.45114872
129KSR20.45085072
130CSF1R0.44857567
131NEK90.44533305
132CSNK1G10.44324001
133CDK50.44152508
134* MAPK80.43983159
135JAK20.43878363
136EIF2AK20.43492296
137TXK0.43218883
138TAOK30.42675562
139FER0.42332833
140TGFBR10.42186986
141OBSCN0.42124424
142PRKCQ0.41877170
143RAF10.41355614

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.62123475
2Nicotine addiction_Homo sapiens_hsa050332.39413576
3Long-term potentiation_Homo sapiens_hsa047202.00993610
4Lysine degradation_Homo sapiens_hsa003101.91511616
5mRNA surveillance pathway_Homo sapiens_hsa030151.85670599
6Circadian entrainment_Homo sapiens_hsa047131.79294066
7Glutamatergic synapse_Homo sapiens_hsa047241.79264881
8Type II diabetes mellitus_Homo sapiens_hsa049301.74189460
9Morphine addiction_Homo sapiens_hsa050321.65989677
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62911150
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62086128
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58088706
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56499182
14Insulin secretion_Homo sapiens_hsa049111.53888274
15Fanconi anemia pathway_Homo sapiens_hsa034601.48430981
16Amphetamine addiction_Homo sapiens_hsa050311.48429457
17Notch signaling pathway_Homo sapiens_hsa043301.46542900
18Axon guidance_Homo sapiens_hsa043601.46502973
19Non-homologous end-joining_Homo sapiens_hsa034501.45321393
20Olfactory transduction_Homo sapiens_hsa047401.44781360
21Circadian rhythm_Homo sapiens_hsa047101.37535243
22RNA transport_Homo sapiens_hsa030131.34599214
23Spliceosome_Homo sapiens_hsa030401.31557495
24Dopaminergic synapse_Homo sapiens_hsa047281.28993044
25GABAergic synapse_Homo sapiens_hsa047271.28559401
26Dorso-ventral axis formation_Homo sapiens_hsa043201.28099271
27Propanoate metabolism_Homo sapiens_hsa006401.27699395
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26767174
29RNA degradation_Homo sapiens_hsa030181.25627083
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22470274
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.19319282
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.19240354
33Protein export_Homo sapiens_hsa030601.18566818
34MicroRNAs in cancer_Homo sapiens_hsa052061.15044140
35Calcium signaling pathway_Homo sapiens_hsa040201.14610415
36Regulation of autophagy_Homo sapiens_hsa041401.13772038
37Taste transduction_Homo sapiens_hsa047421.13476769
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13130918
39mTOR signaling pathway_Homo sapiens_hsa041501.12115641
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11688073
41ErbB signaling pathway_Homo sapiens_hsa040121.09223276
42Inositol phosphate metabolism_Homo sapiens_hsa005621.09171555
43Long-term depression_Homo sapiens_hsa047301.08641534
44Wnt signaling pathway_Homo sapiens_hsa043101.05667480
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05183546
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04107575
47* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03124102
48Oxytocin signaling pathway_Homo sapiens_hsa049211.01957200
49Basal cell carcinoma_Homo sapiens_hsa052171.01777855
50Cholinergic synapse_Homo sapiens_hsa047251.01100935
51Alcoholism_Homo sapiens_hsa050341.00839849
52cAMP signaling pathway_Homo sapiens_hsa040240.99530073
53T cell receptor signaling pathway_Homo sapiens_hsa046600.97599253
54Endometrial cancer_Homo sapiens_hsa052130.97274197
55Renin secretion_Homo sapiens_hsa049240.96356225
56Serotonergic synapse_Homo sapiens_hsa047260.96354269
57TGF-beta signaling pathway_Homo sapiens_hsa043500.96287445
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95605349
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94832719
60Non-small cell lung cancer_Homo sapiens_hsa052230.94392578
61B cell receptor signaling pathway_Homo sapiens_hsa046620.93829604
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93351356
63Salivary secretion_Homo sapiens_hsa049700.92798566
64Choline metabolism in cancer_Homo sapiens_hsa052310.92269562
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92235525
66Hepatitis B_Homo sapiens_hsa051610.91925607
67Cocaine addiction_Homo sapiens_hsa050300.91439985
68p53 signaling pathway_Homo sapiens_hsa041150.91301067
69Colorectal cancer_Homo sapiens_hsa052100.91077541
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90441847
71Primary immunodeficiency_Homo sapiens_hsa053400.90053351
72Legionellosis_Homo sapiens_hsa051340.90030630
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88421061
74Glioma_Homo sapiens_hsa052140.87372946
75MAPK signaling pathway_Homo sapiens_hsa040100.87360332
76Oocyte meiosis_Homo sapiens_hsa041140.86578742
77Measles_Homo sapiens_hsa051620.85658419
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84799592
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84004405
80GnRH signaling pathway_Homo sapiens_hsa049120.82455351
81Cell cycle_Homo sapiens_hsa041100.82295392
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80424702
83Systemic lupus erythematosus_Homo sapiens_hsa053220.77094996
84Type I diabetes mellitus_Homo sapiens_hsa049400.76136212
85Melanogenesis_Homo sapiens_hsa049160.75444006
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.75187173
87FoxO signaling pathway_Homo sapiens_hsa040680.74827681
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74705738
89Leishmaniasis_Homo sapiens_hsa051400.73547364
90Gastric acid secretion_Homo sapiens_hsa049710.72067066
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.71639888
92Adherens junction_Homo sapiens_hsa045200.71473286
93Chronic myeloid leukemia_Homo sapiens_hsa052200.70105773
94Glucagon signaling pathway_Homo sapiens_hsa049220.68925621
95Butanoate metabolism_Homo sapiens_hsa006500.68868348
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67417129
97Synaptic vesicle cycle_Homo sapiens_hsa047210.66977047
98Osteoclast differentiation_Homo sapiens_hsa043800.66806147
99Gap junction_Homo sapiens_hsa045400.66194681
100Steroid biosynthesis_Homo sapiens_hsa001000.65416154
101Estrogen signaling pathway_Homo sapiens_hsa049150.63574112
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.63525322
103Herpes simplex infection_Homo sapiens_hsa051680.63260687
104Hippo signaling pathway_Homo sapiens_hsa043900.63166069
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62974758
106Hedgehog signaling pathway_Homo sapiens_hsa043400.62617622
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62402586
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60900119
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.60887343
110Dilated cardiomyopathy_Homo sapiens_hsa054140.60319839
111Basal transcription factors_Homo sapiens_hsa030220.60045993
112Rap1 signaling pathway_Homo sapiens_hsa040150.59566119
113Selenocompound metabolism_Homo sapiens_hsa004500.58671800
114Hepatitis C_Homo sapiens_hsa051600.58203898
115Renal cell carcinoma_Homo sapiens_hsa052110.57905170
116Prostate cancer_Homo sapiens_hsa052150.57546933
117Pancreatic cancer_Homo sapiens_hsa052120.57355887
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57165037
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57002609
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56118573
121Viral carcinogenesis_Homo sapiens_hsa052030.56035083
122Homologous recombination_Homo sapiens_hsa034400.55903185
123Influenza A_Homo sapiens_hsa051640.55820266
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55186001
125Phototransduction_Homo sapiens_hsa047440.55156735
126Tuberculosis_Homo sapiens_hsa051520.54100742
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53766882
128Ras signaling pathway_Homo sapiens_hsa040140.53248831
129Mismatch repair_Homo sapiens_hsa034300.52644265
130HTLV-I infection_Homo sapiens_hsa051660.52523010
131Prolactin signaling pathway_Homo sapiens_hsa049170.52270909
132Acute myeloid leukemia_Homo sapiens_hsa052210.51429061
133Ether lipid metabolism_Homo sapiens_hsa005650.50542984
134Chemokine signaling pathway_Homo sapiens_hsa040620.50518290
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46385842

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