CCNY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.13244023
2positive regulation by symbiont of host defense response (GO:0052509)4.15692544
3modulation by symbiont of host defense response (GO:0052031)4.15692544
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.15692544
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.15692544
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.15692544
7modulation by symbiont of host immune response (GO:0052553)4.15692544
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05434192
9neutrophil activation involved in immune response (GO:0002283)3.85824710
10positive regulation of gamma-delta T cell activation (GO:0046645)3.78279850
11negative regulation of cell killing (GO:0031342)3.75457833
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75457833
13regulation of T-helper 2 cell differentiation (GO:0045628)3.64464104
14response to peptidoglycan (GO:0032494)3.64303401
15cellular extravasation (GO:0045123)3.56502582
16macrophage activation involved in immune response (GO:0002281)3.40593494
17detection of molecule of bacterial origin (GO:0032490)3.39113163
18positive regulation of fatty acid beta-oxidation (GO:0032000)3.31829592
19alpha-linolenic acid metabolic process (GO:0036109)3.29744192
20regulation of leukocyte degranulation (GO:0043300)3.27907101
21detection of other organism (GO:0098543)3.26418285
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24937438
23protein localization to endosome (GO:0036010)3.15249857
24regulation of mast cell degranulation (GO:0043304)3.13598606
25regulation of early endosome to late endosome transport (GO:2000641)3.09983570
26lysine metabolic process (GO:0006553)3.08033333
27lysine catabolic process (GO:0006554)3.08033333
28positive regulation of cellular amide metabolic process (GO:0034250)3.06259294
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05531538
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05009345
31positive regulation of mast cell activation (GO:0033005)3.03850816
32fatty acid transmembrane transport (GO:1902001)3.01112841
33insulin-like growth factor receptor signaling pathway (GO:0048009)2.99430073
34antigen processing and presentation of endogenous antigen (GO:0019883)2.98535230
35regulation of fatty acid beta-oxidation (GO:0031998)2.97539933
36detection of external biotic stimulus (GO:0098581)2.96863675
37dicarboxylic acid biosynthetic process (GO:0043650)2.96230344
38response to muramyl dipeptide (GO:0032495)2.95024993
39detection of bacterium (GO:0016045)2.89930033
40leukocyte migration involved in inflammatory response (GO:0002523)2.89891117
41positive regulation of receptor recycling (GO:0001921)2.88972333
42regulation of gamma-delta T cell activation (GO:0046643)2.88899913
43cellular response to thyroid hormone stimulus (GO:0097067)2.88694742
44regulation of regulated secretory pathway (GO:1903305)2.87688250
45hypotonic response (GO:0006971)2.84825175
46regulation of mast cell activation involved in immune response (GO:0033006)2.82926657
47positive regulation of fatty acid oxidation (GO:0046321)2.81671846
48response to host (GO:0075136)2.81460227
49response to host defenses (GO:0052200)2.81460227
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81460227
51layer formation in cerebral cortex (GO:0021819)2.81225950
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.77833814
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75944330
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75628420
55response to host immune response (GO:0052572)2.75628420
56plasma membrane repair (GO:0001778)2.74801307
57positive regulation of leukocyte degranulation (GO:0043302)2.73341154
58locomotory exploration behavior (GO:0035641)2.71669696
59regulation of platelet aggregation (GO:0090330)2.71474343
60detection of biotic stimulus (GO:0009595)2.70204321
61carnitine shuttle (GO:0006853)2.69552537
62positive regulation of regulated secretory pathway (GO:1903307)2.68547953
63positive regulation of lipid catabolic process (GO:0050996)2.68255209
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.67557404
65macrophage activation (GO:0042116)2.67090207
66low-density lipoprotein particle clearance (GO:0034383)2.66832308
67response to laminar fluid shear stress (GO:0034616)2.66155426
68regulation of gamma-delta T cell differentiation (GO:0045586)2.64338413
69regulation of B cell receptor signaling pathway (GO:0050855)2.62504812
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.61874857
71regulation of ARF GTPase activity (GO:0032312)2.61222353
72negative regulation of interleukin-12 production (GO:0032695)2.60951793
73lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60719051
74histone H3-K9 demethylation (GO:0033169)2.59893530
75cell migration involved in sprouting angiogenesis (GO:0002042)2.56060614
76positive regulation of Rap GTPase activity (GO:0032854)2.54990305
77synaptic vesicle maturation (GO:0016188)2.54738814
78positive regulation of glycogen biosynthetic process (GO:0045725)2.54334387
79megakaryocyte development (GO:0035855)2.54191045
80regulation of macrophage cytokine production (GO:0010935)2.53826389
81positive regulation of mast cell activation involved in immune response (GO:0033008)2.53755329
82positive regulation of mast cell degranulation (GO:0043306)2.53755329
83peptidyl-glutamic acid carboxylation (GO:0017187)2.53473698
84protein carboxylation (GO:0018214)2.53473698
85myeloid cell activation involved in immune response (GO:0002275)2.53127843
862-oxoglutarate metabolic process (GO:0006103)2.49542378
87microglial cell activation (GO:0001774)2.48510622
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.48182677
89L-phenylalanine catabolic process (GO:0006559)2.48182677
90negative regulation of fibrinolysis (GO:0051918)2.47523502
91cortical actin cytoskeleton organization (GO:0030866)2.45531802
92regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44823970
93peptide catabolic process (GO:0043171)2.44454234
94regulation of fatty acid oxidation (GO:0046320)2.44110513
95antigen processing and presentation via MHC class Ib (GO:0002475)2.43876206
96complement activation, alternative pathway (GO:0006957)2.43597797
97cysteine metabolic process (GO:0006534)2.43204650
98glutamate metabolic process (GO:0006536)2.43147581
99regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.42899964
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.42623038
101negative regulation of inclusion body assembly (GO:0090084)2.41156613
102neutrophil activation (GO:0042119)2.41053214
103regulation of cholesterol homeostasis (GO:2000188)2.40382369
104activation of protein kinase A activity (GO:0034199)2.40193811
105histone H3-K36 demethylation (GO:0070544)2.39033074
106apoptotic cell clearance (GO:0043277)2.38854244
107germinal center formation (GO:0002467)2.38102910
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.37914998
109leukocyte aggregation (GO:0070486)2.37141727
110L-phenylalanine metabolic process (GO:0006558)2.36665407
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36665407
112negative regulation of heart growth (GO:0061117)2.34971619
113negative regulation of cardiac muscle tissue growth (GO:0055022)2.34971619
114regulation of lipid kinase activity (GO:0043550)2.34536949
115midgut development (GO:0007494)2.34313327
116negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.34162068
117plasma lipoprotein particle clearance (GO:0034381)2.33502591
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.33480479
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.33166718
120negative regulation of potassium ion transmembrane transport (GO:1901380)2.31935295
121signal complex assembly (GO:0007172)2.31362989
122growth hormone receptor signaling pathway (GO:0060396)2.31198205
123pinocytosis (GO:0006907)2.31046974
124definitive hemopoiesis (GO:0060216)2.30987235
125negative regulation of cell size (GO:0045792)2.29990748
126regulation of cholesterol storage (GO:0010885)2.29821230
127mannose metabolic process (GO:0006013)2.29769613
128adenosine receptor signaling pathway (GO:0001973)2.28431315
129acylglycerol catabolic process (GO:0046464)2.28309214
130neutral lipid catabolic process (GO:0046461)2.28309214
131regulation of interferon-beta biosynthetic process (GO:0045357)2.28283606
132B cell receptor signaling pathway (GO:0050853)2.28224790
133cellular ketone body metabolic process (GO:0046950)2.27050837
134regulation of mast cell activation (GO:0033003)2.26942369
135positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.26725397
136positive regulation of glycogen metabolic process (GO:0070875)2.26547764
137urea cycle (GO:0000050)2.25999923
138urea metabolic process (GO:0019627)2.25999923
139phospholipid homeostasis (GO:0055091)2.25918023
140positive regulation of type 2 immune response (GO:0002830)2.25885633
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.25830390
142granulocyte activation (GO:0036230)2.25136645
143positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.23661597
144nerve growth factor signaling pathway (GO:0038180)2.22554628
145positive regulation of myotube differentiation (GO:0010831)2.22022662
146leukocyte degranulation (GO:0043299)2.21553043
147endothelium development (GO:0003158)2.20599778
148negative regulation of type 2 immune response (GO:0002829)2.20337848
149stress fiber assembly (GO:0043149)2.19661473
150angiogenesis involved in wound healing (GO:0060055)2.19587308
151negative regulation of fatty acid transport (GO:2000192)2.19408907
152negative regulation of homotypic cell-cell adhesion (GO:0034111)2.19065527
153negative regulation of leukocyte mediated immunity (GO:0002704)2.18589668
154cell adhesion mediated by integrin (GO:0033627)2.18370846
155response to thyroid hormone (GO:0097066)2.18015150
156kynurenine metabolic process (GO:0070189)2.18014598
157blood vessel endothelial cell migration (GO:0043534)2.17855811
158protein targeting to Golgi (GO:0000042)2.17832445
159regulation of ARF protein signal transduction (GO:0032012)2.17418646
160cytoplasmic mRNA processing body assembly (GO:0033962)2.17142746
161aspartate family amino acid catabolic process (GO:0009068)2.17002295
162positive regulation of nitric-oxide synthase activity (GO:0051000)2.16808376
163fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.16485805
164carnitine transmembrane transport (GO:1902603)2.16390895
165sulfur amino acid catabolic process (GO:0000098)2.16228254
166bile acid biosynthetic process (GO:0006699)2.15966096
1674-hydroxyproline metabolic process (GO:0019471)2.15570233
168regulation of protein activation cascade (GO:2000257)2.15307571
169sodium ion export (GO:0071436)2.15259101
170positive regulation of glycolytic process (GO:0045821)2.13505475
171glyoxylate metabolic process (GO:0046487)2.13415610
172positive regulation of histone deacetylation (GO:0031065)2.13219023
173establishment of protein localization to Golgi (GO:0072600)2.13199678
174regulation of fibrinolysis (GO:0051917)2.13014219
175establishment of nucleus localization (GO:0040023)2.12990385
176carnitine transport (GO:0015879)2.11246116
177amino-acid betaine transport (GO:0015838)2.11246116
178regulation of sequestering of triglyceride (GO:0010889)2.11032761
179intracellular lipid transport (GO:0032365)2.10897248
180regulation of clathrin-mediated endocytosis (GO:2000369)2.10492495
181negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.09916214
182cell communication by electrical coupling (GO:0010644)2.09864815
183cellular modified amino acid catabolic process (GO:0042219)2.09655270
184negative regulation of vascular permeability (GO:0043116)2.09094280
185positive regulation of cellular response to insulin stimulus (GO:1900078)2.08607952
186homocysteine metabolic process (GO:0050667)2.08546182
187short-chain fatty acid metabolic process (GO:0046459)2.08357730
188epoxygenase P450 pathway (GO:0019373)2.08317364
189triglyceride catabolic process (GO:0019433)2.07706300
190adherens junction assembly (GO:0034333)2.07674378
191regulation of lipid catabolic process (GO:0050994)2.06862299
192regulation of triglyceride catabolic process (GO:0010896)2.05026216
193regulation of complement activation (GO:0030449)2.04842919
194negative regulation of lipid transport (GO:0032369)2.03496758
195endoplasmic reticulum organization (GO:0007029)2.03140769
196valine metabolic process (GO:0006573)2.02201862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63466303
2RXR_22158963_ChIP-Seq_LIVER_Mouse2.68428951
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67426218
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61087259
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.57060236
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50871052
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31545436
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29242474
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.28348782
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25752156
11SPI1_23127762_ChIP-Seq_K562_Human2.21585001
12SCL_19346495_ChIP-Seq_HPC-7_Human2.21062666
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18904230
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.15182114
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13954134
16CLOCK_20551151_ChIP-Seq_293T_Human2.04030699
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03544286
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.02245112
19VDR_24763502_ChIP-Seq_THP-1_Human2.01832733
20RUNX_20019798_ChIP-Seq_JUKART_Human2.00483374
21VDR_21846776_ChIP-Seq_THP-1_Human1.98755273
22MYC_22102868_ChIP-Seq_BL_Human1.89983759
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.89218302
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85025845
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.84672670
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.83870190
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81256886
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81181635
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77858251
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75112541
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74443619
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.72061200
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67814010
34LXR_22292898_ChIP-Seq_THP-1_Human1.66364524
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65456975
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.63425680
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60795086
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.58527217
39EZH2_22144423_ChIP-Seq_EOC_Human1.57660692
40* MAF_26560356_Chip-Seq_TH1_Human1.56858215
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53371144
42ZNF263_19887448_ChIP-Seq_K562_Human1.52767178
43VDR_24787735_ChIP-Seq_THP-1_Human1.52218897
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51137732
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50904529
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.48541917
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.45958905
48GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44214927
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43354057
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.42021578
51GATA2_19941826_ChIP-Seq_K562_Human1.41917246
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.40619483
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.40534123
54* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39352771
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39139610
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39049847
57DROSHA_22980978_ChIP-Seq_HELA_Human1.37104974
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36196890
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35687478
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34919847
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34144496
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34144496
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31174371
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30669427
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.29437228
66KDM2B_26808549_Chip-Seq_K562_Human1.29141110
67KDM2B_26808549_Chip-Seq_DND41_Human1.28784427
68TP53_16413492_ChIP-PET_HCT116_Human1.28655755
69* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27308400
70UTX_26944678_Chip-Seq_JUKART_Human1.27157337
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.26731332
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25921008
73AR_21572438_ChIP-Seq_LNCaP_Human1.24051721
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.23663762
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.22588036
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.22588036
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22565632
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22565632
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22340311
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22238978
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.21693818
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21621041
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21017850
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20021132
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19439373
86NCOR1_26117541_ChIP-Seq_K562_Human1.19258484
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.19020436
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18167799
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17357262
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16285989
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15258489
92GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15243948
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.15133149
94* RACK7_27058665_Chip-Seq_MCF-7_Human1.14999124
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14375134
96GATA1_22025678_ChIP-Seq_K562_Human1.13660760
97SPI1_23547873_ChIP-Seq_NB4_Human1.12856915
98MYB_26560356_Chip-Seq_TH2_Human1.11813386
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11636023
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11110725
101RXR_22108803_ChIP-Seq_LS180_Human1.10066164
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09414269
103* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09370865
104AHR_22903824_ChIP-Seq_MCF-7_Human1.08943402
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07755377
106BCAT_22108803_ChIP-Seq_LS180_Human1.07090109
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07082146
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06111877
109MYB_26560356_Chip-Seq_TH1_Human1.06015153
110ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05601805
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05593451
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05211530
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04988117
114JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03545982
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03416584
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03266685
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03204904
118PU_27001747_Chip-Seq_BMDM_Mouse1.02830625
119CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02556415
120ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02375130
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02335977
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.02186412
123SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01049504
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00787205
125* MAF_26560356_Chip-Seq_TH2_Human1.00658391
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00233903
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99443650
128ZNF274_21170338_ChIP-Seq_K562_Hela0.99167719
129SOX2_21211035_ChIP-Seq_LN229_Gbm0.98639617
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98205139
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.98127696
132TCF7_22412390_ChIP-Seq_EML_Mouse0.97954396
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97849754
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97786637
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97295913
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96887617
137* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96214166
138CJUN_26792858_Chip-Seq_BT549_Human0.95620332
139* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95570712
140* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95516599
141GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95363904
142SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94762621
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94728366
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94577519
145GATA1_19941826_ChIP-Seq_K562_Human0.93853916
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93520954
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92745226
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.92660117
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92612347
150* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92574085
151JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91886072
152STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91803590
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90859815
154* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90620539
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.90619128
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90157281
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90067400
158AR_19668381_ChIP-Seq_PC3_Human0.89807140
159PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89656567
160ISL1_27105846_Chip-Seq_CPCs_Mouse0.89240159
161EED_16625203_ChIP-ChIP_MESCs_Mouse0.88781493
162RNF2_27304074_Chip-Seq_ESCs_Mouse0.88500434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.59322354
2MP0002139_abnormal_hepatobiliary_system3.56327971
3MP0003705_abnormal_hypodermis_morpholog3.45537064
4MP0010234_abnormal_vibrissa_follicle3.14904125
5MP0005464_abnormal_platelet_physiology3.10892389
6MP0003724_increased_susceptibility_to2.95150093
7MP0003436_decreased_susceptibility_to2.88166032
8MP0005085_abnormal_gallbladder_physiolo2.85425352
9MP0004130_abnormal_muscle_cell2.81510804
10MP0005365_abnormal_bile_salt2.66346149
11MP0004859_abnormal_synaptic_plasticity2.46715918
12MP0003300_gastrointestinal_ulcer2.43479132
13MP0009780_abnormal_chondrocyte_physiolo2.41205408
14MP0005058_abnormal_lysosome_morphology2.36636620
15MP0005409_darkened_coat_color2.36556380
16MP0005451_abnormal_body_composition2.22593554
17MP0004185_abnormal_adipocyte_glucose2.16913000
18MP0010329_abnormal_lipoprotein_level2.13429669
19MP0003252_abnormal_bile_duct2.11776119
20MP0005167_abnormal_blood-brain_barrier2.09716926
21MP0002837_dystrophic_cardiac_calcinosis2.03713766
22MP0002419_abnormal_innate_immunity2.00467625
23MP0008875_abnormal_xenobiotic_pharmacok2.00235386
24MP0001835_abnormal_antigen_presentation1.98016438
25MP0000013_abnormal_adipose_tissue1.86971196
26MP0008260_abnormal_autophagy1.86536959
27MP0010368_abnormal_lymphatic_system1.86358496
28MP0003303_peritoneal_inflammation1.84075588
29MP0008438_abnormal_cutaneous_collagen1.80372847
30MP0005410_abnormal_fertilization1.69603439
31MP0008961_abnormal_basal_metabolism1.69462163
32MP0004272_abnormal_basement_membrane1.65934639
33MP0004084_abnormal_cardiac_muscle1.64369712
34MP0005666_abnormal_adipose_tissue1.61038459
35MP0001533_abnormal_skeleton_physiology1.59030228
36MP0008004_abnormal_stomach_pH1.57662378
37MP0002909_abnormal_adrenal_gland1.56542136
38MP0009278_abnormal_bone_marrow1.54737567
39MP0000465_gastrointestinal_hemorrhage1.54229637
40MP0000751_myopathy1.52879437
41MP0003191_abnormal_cellular_cholesterol1.52218548
42MP0002998_abnormal_bone_remodeling1.51893531
43MP0004947_skin_inflammation1.50080325
44MP0001851_eye_inflammation1.48305368
45MP0005025_abnormal_response_to1.47894524
46MP0004883_abnormal_blood_vessel1.44970965
47MP0000537_abnormal_urethra_morphology1.43458794
48MP0005187_abnormal_penis_morphology1.41780178
49MP0005000_abnormal_immune_tolerance1.41003629
50MP0004087_abnormal_muscle_fiber1.40281074
51MP0005375_adipose_tissue_phenotype1.38980940
52MP0004510_myositis1.38324497
53MP0005623_abnormal_meninges_morphology1.36933918
54MP0005076_abnormal_cell_differentiation1.36569941
55MP0002009_preneoplasia1.35683977
56MP0002132_abnormal_respiratory_system1.35538028
57MP0004808_abnormal_hematopoietic_stem1.34746234
58MP0002118_abnormal_lipid_homeostasis1.34658912
59MP0004036_abnormal_muscle_relaxation1.34597708
60MP0003183_abnormal_peptide_metabolism1.34499399
61MP0006082_CNS_inflammation1.34119019
62MP0000604_amyloidosis1.33003457
63MP0003566_abnormal_cell_adhesion1.31882151
64MP0003279_aneurysm1.31542595
65MP0000003_abnormal_adipose_tissue1.31047037
66MP0002420_abnormal_adaptive_immunity1.29810301
67MP0003195_calcinosis1.29409010
68MP0002723_abnormal_immune_serum1.29069737
69MP0001819_abnormal_immune_cell1.27909522
70MP0004484_altered_response_of1.27752270
71MP0002877_abnormal_melanocyte_morpholog1.26792499
72MP0005397_hematopoietic_system_phenotyp1.26609767
73MP0001545_abnormal_hematopoietic_system1.26609767
74MP0000858_altered_metastatic_potential1.26158804
75MP0003690_abnormal_glial_cell1.26006554
76MP0002896_abnormal_bone_mineralization1.25329134
77MP0001800_abnormal_humoral_immune1.24220299
78MP0002452_abnormal_antigen_presenting1.23989033
79MP0000747_muscle_weakness1.22182325
80MP0005330_cardiomyopathy1.21985360
81MP0003329_amyloid_beta_deposits1.21857001
82MP0009384_cardiac_valve_regurgitation1.21331612
83MP0005164_abnormal_response_to1.19719639
84MP0000685_abnormal_immune_system1.19225485
85MP0002398_abnormal_bone_marrow1.18273209
86MP0003045_fibrosis1.18250719
87MP0000767_abnormal_smooth_muscle1.18038082
88MP0004215_abnormal_myocardial_fiber1.17589452
89MP0001666_abnormal_nutrient_absorption1.17411887
90MP0003448_altered_tumor_morphology1.17093457
91MP0001879_abnormal_lymphatic_vessel1.14566330
92MP0003075_altered_response_to1.14545753
93MP0005332_abnormal_amino_acid1.14076290
94MP0001915_intracranial_hemorrhage1.13885605
95MP0001790_abnormal_immune_system1.13444046
96MP0005387_immune_system_phenotype1.13444046
97MP0000609_abnormal_liver_physiology1.12977925
98MP0002971_abnormal_brown_adipose1.11101385
99MP0005275_abnormal_skin_tensile1.10673155
100MP0005620_abnormal_muscle_contractility1.10332955
101MP0002396_abnormal_hematopoietic_system1.08057473
102MP0003453_abnormal_keratinocyte_physiol1.07484196
103MP0003091_abnormal_cell_migration1.06742748
104MP0010630_abnormal_cardiac_muscle1.06727113
105MP0002405_respiratory_system_inflammati1.06385960
106MP0010155_abnormal_intestine_physiology1.06338025
107MP0005083_abnormal_biliary_tract1.06088864
108MP0005248_abnormal_Harderian_gland1.05997342
109MP0003868_abnormal_feces_composition1.05733061
110MP0000249_abnormal_blood_vessel1.05724570
111MP0002972_abnormal_cardiac_muscle1.04902994
112MP0003763_abnormal_thymus_physiology1.04878643
113MP0000343_altered_response_to1.04630793
114MP0001348_abnormal_lacrimal_gland1.04277188
115MP0003656_abnormal_erythrocyte_physiolo1.03003418
116MP0000733_abnormal_muscle_development1.00188643
117MP0003635_abnormal_synaptic_transmissio0.99488341
118MP0000716_abnormal_immune_system0.98904998
119MP0004858_abnormal_nervous_system0.97987915
120MP0008775_abnormal_heart_ventricle0.97495174
121MP0003828_pulmonary_edema0.97081357
122MP0005670_abnormal_white_adipose0.97077878
123MP0005310_abnormal_salivary_gland0.96615607
124MP0004145_abnormal_muscle_electrophysio0.96579499
125MP0004270_analgesia0.95914116
126MP0001849_ear_inflammation0.92173869
127MP0003633_abnormal_nervous_system0.91993730
128MP0006138_congestive_heart_failure0.91984546
129MP0002722_abnormal_immune_system0.89565703
130MP0000569_abnormal_digit_pigmentation0.89479227
131MP0002166_altered_tumor_susceptibility0.89253406
132MP0005023_abnormal_wound_healing0.88733995
133MP0000703_abnormal_thymus_morphology0.88017569
134MP0005385_cardiovascular_system_phenoty0.87911362
135MP0001544_abnormal_cardiovascular_syste0.87911362
136MP0010352_gastrointestinal_tract_polyps0.87739218
137MP0002269_muscular_atrophy0.87518012
138MP0002078_abnormal_glucose_homeostasis0.86895118
139MP0000749_muscle_degeneration0.86721228
140MP0008874_decreased_physiological_sensi0.86375703
141MP0002429_abnormal_blood_cell0.85621000
142MP0002133_abnormal_respiratory_system0.85387074
143MP0005388_respiratory_system_phenotype0.85387074
144MP0005535_abnormal_body_temperature0.85265667
145MP0010678_abnormal_skin_adnexa0.85111822
146MP0000678_abnormal_parathyroid_gland0.84752847
147MP0005166_decreased_susceptibility_to0.84624573
148MP0009785_altered_susceptibility_to0.84506703
149MP0001845_abnormal_inflammatory_respons0.84424581
150MP0009840_abnormal_foam_cell0.84021846
151MP0005319_abnormal_enzyme/_coenzyme0.83144871
152MP0001958_emphysema0.82858288
153MP0002148_abnormal_hypersensitivity_rea0.82767539
154MP0009115_abnormal_fat_cell0.81121408
155MP0004085_abnormal_heartbeat0.80655258
156MP0002063_abnormal_learning/memory/cond0.80523074
157MP0003172_abnormal_lysosome_physiology0.79719533
158MP0003879_abnormal_hair_cell0.79464709
159MP0001614_abnormal_blood_vessel0.79427589
160MP0000759_abnormal_skeletal_muscle0.77252666
161MP0005390_skeleton_phenotype0.76329278
162MP0009053_abnormal_anal_canal0.75851422
163MP0001299_abnormal_eye_distance/0.75067658
164MP0006054_spinal_hemorrhage0.73715572
165MP0002090_abnormal_vision0.73352094
166MP0002168_other_aberrant_phenotype0.72980513
167MP0002128_abnormal_blood_circulation0.72251696
168MP0005584_abnormal_enzyme/coenzyme_acti0.71770777
169MP0005334_abnormal_fat_pad0.70886023
170MP0002295_abnormal_pulmonary_circulatio0.69600122
171MP0004233_abnormal_muscle_weight0.67007929

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.93046130
2Deep venous thrombosis (HP:0002625)3.87752565
3Prolonged bleeding time (HP:0003010)3.70113354
4Spontaneous hematomas (HP:0007420)3.64701264
5Recurrent bacterial skin infections (HP:0005406)3.29552742
6Abnormality of macrophages (HP:0004311)3.29313688
7Recurrent abscess formation (HP:0002722)3.26839441
8Abnormal platelet volume (HP:0011876)3.00510883
9Subacute progressive viral hepatitis (HP:0006572)2.96110008
10Peritonitis (HP:0002586)2.95267024
11Epistaxis (HP:0000421)2.86154456
12Lymphangioma (HP:0100764)2.84226760
13Xanthomatosis (HP:0000991)2.82272835
14Gingival bleeding (HP:0000225)2.79854469
15Abnormality of the Achilles tendon (HP:0005109)2.76668670
16Menorrhagia (HP:0000132)2.73449010
17Recurrent gram-negative bacterial infections (HP:0005420)2.72691059
18Increased mean platelet volume (HP:0011877)2.72023165
19Papilledema (HP:0001085)2.71424093
20Purpura (HP:0000979)2.64819004
21Cerebral aneurysm (HP:0004944)2.62189966
22Achilles tendon contracture (HP:0001771)2.60922682
23Vascular tortuosity (HP:0004948)2.57040301
24Complement deficiency (HP:0004431)2.54800871
25Gingivitis (HP:0000230)2.52345720
26Hyporeflexia of lower limbs (HP:0002600)2.51711328
27Exercise-induced muscle cramps (HP:0003710)2.51289054
28Hypoglycemic coma (HP:0001325)2.49049855
29Mitral valve prolapse (HP:0001634)2.44297232
30Hypoalphalipoproteinemia (HP:0003233)2.43634345
31Gastrointestinal infarctions (HP:0005244)2.41113934
32Ketoacidosis (HP:0001993)2.40829840
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38274539
34Ketosis (HP:0001946)2.37677063
35Myositis (HP:0100614)2.37127636
36Amyloidosis (HP:0011034)2.35764759
37Hematochezia (HP:0002573)2.34960769
38Cellulitis (HP:0100658)2.34761404
39Intrahepatic cholestasis (HP:0001406)2.33902749
40Difficulty running (HP:0009046)2.31660075
41Macroorchidism (HP:0000053)2.29918145
42Orchitis (HP:0100796)2.24766221
43Myocardial infarction (HP:0001658)2.23451134
44Sudden death (HP:0001699)2.22701522
45Hyperlipoproteinemia (HP:0010980)2.20745299
46Epidermoid cyst (HP:0200040)2.19553558
47Protrusio acetabuli (HP:0003179)2.19114105
48Exercise-induced myalgia (HP:0003738)2.18613009
49Chronic obstructive pulmonary disease (HP:0006510)2.18224275
50Obstructive lung disease (HP:0006536)2.18224275
51Myoglobinuria (HP:0002913)2.17825111
52Skin nodule (HP:0200036)2.17192193
53Increased connective tissue (HP:0009025)2.16205241
54Obstructive sleep apnea (HP:0002870)2.13054218
55Aortic aneurysm (HP:0004942)2.12212431
56Spondylolisthesis (HP:0003302)2.11332778
57Abnormality of the common coagulation pathway (HP:0010990)2.09720889
58Aneurysm (HP:0002617)2.07831723
59Termporal pattern (HP:0011008)2.07644872
60Insidious onset (HP:0003587)2.07644872
61Hepatocellular carcinoma (HP:0001402)2.05067794
62Cerebral inclusion bodies (HP:0100314)2.04545554
63Abnormal platelet function (HP:0011869)2.04006689
64Impaired platelet aggregation (HP:0003540)2.04006689
65Dysostosis multiplex (HP:0000943)2.01398533
66Striae distensae (HP:0001065)1.98780209
67Broad metatarsal (HP:0001783)1.98484663
68Buphthalmos (HP:0000557)1.97450057
69Mitral stenosis (HP:0001718)1.97203902
70Enlarged penis (HP:0000040)1.95251900
71Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94170077
72Recurrent skin infections (HP:0001581)1.94036849
73Retrobulbar optic neuritis (HP:0100654)1.93911328
74Optic neuritis (HP:0100653)1.93911328
75Arterial thrombosis (HP:0004420)1.92638885
76Asymmetric septal hypertrophy (HP:0001670)1.91874564
77Hypolipoproteinemia (HP:0010981)1.91805498
78Shallow orbits (HP:0000586)1.91465430
79Ankyloglossia (HP:0010296)1.90836604
80Dysmetric saccades (HP:0000641)1.90223663
81Abnormality of the lower motor neuron (HP:0002366)1.88418657
82Bundle branch block (HP:0011710)1.88218192
83Global brain atrophy (HP:0002283)1.86404654
84Distal lower limb amyotrophy (HP:0008944)1.86369152
85Type 1 muscle fiber predominance (HP:0003803)1.86053604
86Segmental peripheral demyelination/remyelination (HP:0003481)1.85330685
87Visceral angiomatosis (HP:0100761)1.84932308
88Petechiae (HP:0000967)1.84874875
89Abnormality of the nasal mucosa (HP:0000433)1.84320490
90Slow saccadic eye movements (HP:0000514)1.84157575
91Difficulty climbing stairs (HP:0003551)1.83817103
92Hyperinsulinemic hypoglycemia (HP:0000825)1.83766606
93Distal lower limb muscle weakness (HP:0009053)1.83507748
94Episodic fever (HP:0001954)1.83138332
95Polycythemia (HP:0001901)1.82902804
96Turricephaly (HP:0000262)1.82630529
97Esophageal varix (HP:0002040)1.82606755
98Increased variability in muscle fiber diameter (HP:0003557)1.82273272
99Fatigue (HP:0012378)1.81944373
100Calf muscle hypertrophy (HP:0008981)1.81762049
101Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81280900
102Spinal cord lesions (HP:0100561)1.80588012
103Syringomyelia (HP:0003396)1.80588012
104Flat acetabular roof (HP:0003180)1.79499548
105Frequent falls (HP:0002359)1.78826020
106Long toe (HP:0010511)1.78820487
107Abnormality of the peritoneum (HP:0002585)1.78310784
108Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77733447
109Abnormal social behavior (HP:0012433)1.77327419
110Impaired social interactions (HP:0000735)1.77327419
111Right ventricular cardiomyopathy (HP:0011663)1.76704376
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76524454
113Abnormality of complement system (HP:0005339)1.75747498
114Resting tremor (HP:0002322)1.75197867
115Hemangiomatosis (HP:0007461)1.74692443
116Lower limb amyotrophy (HP:0007210)1.74566389
117Hemorrhage of the eye (HP:0011885)1.74516523
118Bruising susceptibility (HP:0000978)1.74078854
119Dilatation of the ascending aorta (HP:0005111)1.73699045
120Abnormality of the fingertips (HP:0001211)1.72979998
121Spastic diplegia (HP:0001264)1.72184413
122Neurofibrillary tangles (HP:0002185)1.72167803
123Hyperglycemia (HP:0003074)1.72056620
124Chest pain (HP:0100749)1.71468701
125Gastrointestinal inflammation (HP:0004386)1.71238646
126Overgrowth (HP:0001548)1.70877563
127Abnormality of oral frenula (HP:0000190)1.70718313
128Disproportionate tall stature (HP:0001519)1.68918274
129Hamartoma of the eye (HP:0010568)1.68791611
130Distal upper limb amyotrophy (HP:0007149)1.68470682
131Upper limb amyotrophy (HP:0009129)1.68470682
132Pulmonary embolism (HP:0002204)1.68420420
133Increased CSF protein (HP:0002922)1.68335966
134Metaphyseal cupping (HP:0003021)1.68321168
135Hypoglycemic seizures (HP:0002173)1.67794883
136Thrombocytosis (HP:0001894)1.67654271
137Subaortic stenosis (HP:0001682)1.67424409
138Abnormality of the left ventricular outflow tract (HP:0011103)1.67424409
139Inflammation of the large intestine (HP:0002037)1.66816890
140Hyperammonemia (HP:0001987)1.66691803
141Muscle hypertrophy of the lower extremities (HP:0008968)1.65281587
142Decreased motor nerve conduction velocity (HP:0003431)1.65226753
143Scapular winging (HP:0003691)1.64929729
144Onion bulb formation (HP:0003383)1.63850991
145Bowel incontinence (HP:0002607)1.63669533
146Nasal polyposis (HP:0100582)1.63285222
147Broad face (HP:0000283)1.62721279
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.62333570
149Osteolytic defects of the hand bones (HP:0009699)1.62333570
150Aortic dissection (HP:0002647)1.62307285
151Centrally nucleated skeletal muscle fibers (HP:0003687)1.61695719
152Meningitis (HP:0001287)1.61267691
153Osteomyelitis (HP:0002754)1.60815001
154Atrioventricular block (HP:0001678)1.60811319
155Abnormality of the calf musculature (HP:0001430)1.59979757
156Recurrent fungal infections (HP:0002841)1.59855154
157Colitis (HP:0002583)1.59432906
158Bronchomalacia (HP:0002780)1.59368385
159Hypercholesterolemia (HP:0003124)1.59051589
160Premature rupture of membranes (HP:0001788)1.58769614
161Polygenic inheritance (HP:0010982)1.57487032
162Thin bony cortex (HP:0002753)1.57327607
163Exostoses (HP:0100777)1.57143050
164Hypobetalipoproteinemia (HP:0003563)1.56717242
165Abnormality of the vasculature of the conjunctiva (HP:0008054)1.56599264
166Abnormal large intestine physiology (HP:0012700)1.56186696
167Mucopolysacchariduria (HP:0008155)1.55465002
168Action tremor (HP:0002345)1.55252036
169Arterial tortuosity (HP:0005116)1.55007953
170Abnormality of the intrinsic pathway (HP:0010989)1.54816211
171Postural instability (HP:0002172)1.54173493
172Back pain (HP:0003418)1.52720813
173Urinary urgency (HP:0000012)1.52327897
174Increased density of long bones (HP:0006392)1.51180666
175Abnormality of skeletal muscle fiber size (HP:0012084)1.50820473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.24979483
2PRPF4B3.53514734
3PKN23.48318173
4RIPK12.60172105
5MAP2K32.54879695
6TTN2.24546930
7SIK12.21233383
8KSR22.00282736
9MAP3K91.98064705
10PDGFRA1.97440885
11LATS11.85500278
12MAP3K21.80883035
13EPHA41.79470451
14NTRK31.75241199
15DMPK1.67555830
16FRK1.65259512
17ZAP701.61195447
18PTK61.59778201
19PRKD31.58284005
20BLK1.57908389
21INSRR1.57501860
22MAP3K101.50712552
23NTRK11.50351238
24SCYL21.48791033
25CAMKK11.47563470
26KSR11.44952162
27RET1.44711000
28FGFR21.43021763
29ERN11.42513170
30TYK21.39666306
31IRAK41.39619142
32BMPR21.33873977
33DAPK21.31558354
34CAMK1G1.26224577
35MAP3K141.26018428
36MAP3K31.24191603
37MARK21.21613425
38MAP3K61.19737853
39YES11.18843372
40FER1.15979533
41TIE11.15586764
42BTK1.15307374
43PDK41.14371530
44PDK31.14371530
45MOS1.13899352
46CAMK1D1.13179871
47HCK1.11136469
48MAP3K71.11104059
49PDGFRB1.09791006
50BMX1.09379419
51DDR21.09258543
52JAK31.08984912
53PAK61.07919633
54MAP2K41.07413546
55EEF2K1.07041916
56MAP4K11.06401671
57PIK3CG1.05789185
58SIK21.04667958
59TYRO31.04089280
60RIPK41.00657734
61FGFR31.00545939
62PRKCH1.00379749
63MAP3K40.97871934
64LRRK20.96985688
65PDPK10.96379382
66SMG10.96321104
67PTK2B0.94769752
68TAOK10.94732841
69PDK10.90509346
70FGFR40.89693103
71ICK0.89565238
72LMTK20.89185400
73IRAK30.88968791
74ARAF0.88354496
75PTK20.88331882
76IRAK20.88201628
77PAK30.87923727
78SGK30.85086406
79CDK60.84695755
80ALK0.84369790
81TGFBR20.83854966
82SGK20.82905286
83SYK0.82176803
84MINK10.81602448
85JAK10.80569691
86EPHB10.80137305
87MAP3K10.79035313
88PHKG10.78234109
89PHKG20.78234109
90LATS20.77491282
91TESK10.75994871
92TNK20.75824850
93MAPK120.75456838
94PRKD10.74743401
95MAP2K10.74285876
96STK380.73604587
97MAP3K130.72190699
98STK110.71547086
99GRK60.71485181
100RPS6KA20.70690070
101CSF1R0.69787932
102FES0.69726433
103JAK20.67719593
104BRD40.65979938
105MAPK70.65072097
106TAOK20.64921610
107EPHB20.64819385
108NEK90.63794188
109RPS6KC10.63195050
110RPS6KL10.63195050
111RAF10.62264774
112BCKDK0.62108253
113PAK20.61282416
114CDK50.59526050
115MTOR0.59103306
116HIPK20.58495259
117MET0.57131919
118MAP3K110.56258716
119PDK20.55534697
120SGK4940.55478815
121SGK2230.55478815
122PRKD20.55381519
123MAP3K80.54698543
124STK30.53451773
125FGFR10.53432170
126IRAK10.52816747
127MATK0.52262285
128CDC42BPA0.51549928
129CDK120.51251385
130TRPM70.50165841
131WNK10.48880350
132PRKG20.48648993
133FYN0.48509957
134MARK10.47844048
135EGFR0.47807629
136MST1R0.47350132
137ERBB20.47278650
138CAMKK20.46556250
139ROCK10.46169277
140WNK40.44626591
141KDR0.43681619
142FGR0.42785908
143DYRK1B0.41463834
144CSK0.40577137
145GSK3A0.40419804
146* SGK10.40227002
147NEK10.39876502

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.09802187
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30442113
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25873852
4Arginine biosynthesis_Homo sapiens_hsa002202.05192486
5B cell receptor signaling pathway_Homo sapiens_hsa046621.94827578
6Primary bile acid biosynthesis_Homo sapiens_hsa001201.93781876
7Osteoclast differentiation_Homo sapiens_hsa043801.93610771
8Acute myeloid leukemia_Homo sapiens_hsa052211.79982890
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74466035
10Pancreatic cancer_Homo sapiens_hsa052121.63793428
11Fatty acid degradation_Homo sapiens_hsa000711.63472131
12Leishmaniasis_Homo sapiens_hsa051401.59776561
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57884997
14Bile secretion_Homo sapiens_hsa049761.51034226
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47123375
16PPAR signaling pathway_Homo sapiens_hsa033201.46499091
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44629196
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33050468
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.32672701
20Complement and coagulation cascades_Homo sapiens_hsa046101.31544037
21T cell receptor signaling pathway_Homo sapiens_hsa046601.28868614
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26638827
23Propanoate metabolism_Homo sapiens_hsa006401.25539616
24Chemokine signaling pathway_Homo sapiens_hsa040621.24978505
25Fatty acid metabolism_Homo sapiens_hsa012121.24405827
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23844026
27Butanoate metabolism_Homo sapiens_hsa006501.23063798
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22874591
29Other glycan degradation_Homo sapiens_hsa005111.18342910
30Dorso-ventral axis formation_Homo sapiens_hsa043201.18192710
31Prolactin signaling pathway_Homo sapiens_hsa049171.18157525
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18141611
33Tuberculosis_Homo sapiens_hsa051521.16952639
34Type II diabetes mellitus_Homo sapiens_hsa049301.16153902
35Insulin resistance_Homo sapiens_hsa049311.13875176
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13716459
37Long-term potentiation_Homo sapiens_hsa047201.13440347
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12235069
39Inositol phosphate metabolism_Homo sapiens_hsa005621.11360678
40Tryptophan metabolism_Homo sapiens_hsa003801.10722150
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10478380
42Toxoplasmosis_Homo sapiens_hsa051451.08213845
43Sphingolipid signaling pathway_Homo sapiens_hsa040711.08138613
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07670390
45Glioma_Homo sapiens_hsa052141.06788825
46Endocytosis_Homo sapiens_hsa041441.05537187
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05199388
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05135892
49Renin secretion_Homo sapiens_hsa049241.05065520
50Thyroid cancer_Homo sapiens_hsa052161.00863684
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.00496875
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98529061
53Notch signaling pathway_Homo sapiens_hsa043300.98064850
54mTOR signaling pathway_Homo sapiens_hsa041500.96467607
55Dilated cardiomyopathy_Homo sapiens_hsa054140.96087655
56Hepatitis B_Homo sapiens_hsa051610.95996863
57Glucagon signaling pathway_Homo sapiens_hsa049220.95652645
58Gastric acid secretion_Homo sapiens_hsa049710.94658125
59Malaria_Homo sapiens_hsa051440.94456933
60Colorectal cancer_Homo sapiens_hsa052100.94231424
61Focal adhesion_Homo sapiens_hsa045100.94092048
62Fatty acid biosynthesis_Homo sapiens_hsa000610.93970040
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92922432
64Estrogen signaling pathway_Homo sapiens_hsa049150.92034114
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90107682
66Prostate cancer_Homo sapiens_hsa052150.89909045
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89762252
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.88956712
69TNF signaling pathway_Homo sapiens_hsa046680.87018825
70Caffeine metabolism_Homo sapiens_hsa002320.86517317
71FoxO signaling pathway_Homo sapiens_hsa040680.86283248
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85584706
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85472943
74Lysine degradation_Homo sapiens_hsa003100.85324657
75Oxytocin signaling pathway_Homo sapiens_hsa049210.84526151
76Measles_Homo sapiens_hsa051620.83088989
77Influenza A_Homo sapiens_hsa051640.82133306
78MAPK signaling pathway_Homo sapiens_hsa040100.81903753
79HIF-1 signaling pathway_Homo sapiens_hsa040660.81755562
80VEGF signaling pathway_Homo sapiens_hsa043700.81718268
81AMPK signaling pathway_Homo sapiens_hsa041520.81178857
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80686006
83Salivary secretion_Homo sapiens_hsa049700.80579722
84Bladder cancer_Homo sapiens_hsa052190.80489511
85Staphylococcus aureus infection_Homo sapiens_hsa051500.80314878
86Shigellosis_Homo sapiens_hsa051310.80235944
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.80135345
88Insulin signaling pathway_Homo sapiens_hsa049100.79020800
89Circadian entrainment_Homo sapiens_hsa047130.78549534
90Insulin secretion_Homo sapiens_hsa049110.77208468
91Phagosome_Homo sapiens_hsa041450.76953408
92Proteoglycans in cancer_Homo sapiens_hsa052050.76467908
93Starch and sucrose metabolism_Homo sapiens_hsa005000.75494503
94Amoebiasis_Homo sapiens_hsa051460.75307989
95Hepatitis C_Homo sapiens_hsa051600.73849995
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73640701
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72990172
98Fat digestion and absorption_Homo sapiens_hsa049750.72587240
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.71508159
100Amphetamine addiction_Homo sapiens_hsa050310.71329201
101Prion diseases_Homo sapiens_hsa050200.70643403
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70568865
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69458645
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68691539
105Renal cell carcinoma_Homo sapiens_hsa052110.68462856
106Adherens junction_Homo sapiens_hsa045200.67704161
107Small cell lung cancer_Homo sapiens_hsa052220.67684706
108Cholinergic synapse_Homo sapiens_hsa047250.67622399
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66740192
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66502456
111Glutamatergic synapse_Homo sapiens_hsa047240.65957426
112Glycerolipid metabolism_Homo sapiens_hsa005610.65522254
113Chronic myeloid leukemia_Homo sapiens_hsa052200.65454425
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.64950009
115Endometrial cancer_Homo sapiens_hsa052130.64164783
116Non-small cell lung cancer_Homo sapiens_hsa052230.63964906
117Salmonella infection_Homo sapiens_hsa051320.63942892
118Hematopoietic cell lineage_Homo sapiens_hsa046400.63565133
119Thyroid hormone synthesis_Homo sapiens_hsa049180.63535722
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63516041
121ECM-receptor interaction_Homo sapiens_hsa045120.63088465
122Pertussis_Homo sapiens_hsa051330.63048039
123GnRH signaling pathway_Homo sapiens_hsa049120.62812072
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61709098
125Legionellosis_Homo sapiens_hsa051340.61296193
126Ras signaling pathway_Homo sapiens_hsa040140.61142904
127GABAergic synapse_Homo sapiens_hsa047270.60916334
128Gap junction_Homo sapiens_hsa045400.60866359
129Dopaminergic synapse_Homo sapiens_hsa047280.60777160
130Platelet activation_Homo sapiens_hsa046110.60648171
131cAMP signaling pathway_Homo sapiens_hsa040240.60478105
132Long-term depression_Homo sapiens_hsa047300.59444002
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.59165410
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58566492
135Apoptosis_Homo sapiens_hsa042100.57580329
136Lysosome_Homo sapiens_hsa041420.57149414
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56579172
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55404913
139Axon guidance_Homo sapiens_hsa043600.55373335
140Carbon metabolism_Homo sapiens_hsa012000.55224647
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.55028868
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54228050
143Viral myocarditis_Homo sapiens_hsa054160.54062223
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52787049
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.52406253
146beta-Alanine metabolism_Homo sapiens_hsa004100.51199116
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50817190
148ErbB signaling pathway_Homo sapiens_hsa040120.49395917
149Pancreatic secretion_Homo sapiens_hsa049720.49352285
150Selenocompound metabolism_Homo sapiens_hsa004500.49301860
151Pyruvate metabolism_Homo sapiens_hsa006200.49189020
152Melanogenesis_Homo sapiens_hsa049160.48244171
153Morphine addiction_Homo sapiens_hsa050320.48180602
154Choline metabolism in cancer_Homo sapiens_hsa052310.46922958
155Rap1 signaling pathway_Homo sapiens_hsa040150.46802365

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