CCNYL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.37653927
2paraxial mesoderm development (GO:0048339)4.85733385
3piRNA metabolic process (GO:0034587)4.85245941
4regulation of DNA methylation (GO:0044030)4.71184309
5multicellular organism reproduction (GO:0032504)4.54688390
6synaptonemal complex assembly (GO:0007130)4.54340697
7acrosome assembly (GO:0001675)4.36717279
8synaptonemal complex organization (GO:0070193)4.34085377
9sperm-egg recognition (GO:0035036)4.33334438
10male meiosis (GO:0007140)4.21164611
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.16538539
12regulation of transforming growth factor beta2 production (GO:0032909)4.16079690
13regulation of meiosis I (GO:0060631)4.08435739
14negative regulation of keratinocyte proliferation (GO:0010839)4.05122415
15sperm motility (GO:0030317)4.04894425
16mitotic metaphase plate congression (GO:0007080)4.04830715
17axon ensheathment (GO:0008366)4.03153432
18ensheathment of neurons (GO:0007272)4.03153432
19central nervous system myelination (GO:0022010)4.01309053
20axon ensheathment in central nervous system (GO:0032291)4.01309053
21binding of sperm to zona pellucida (GO:0007339)4.00974145
22myelination (GO:0042552)3.93411486
23plasma membrane fusion (GO:0045026)3.91849461
24cell-cell recognition (GO:0009988)3.86738227
25reproduction (GO:0000003)3.80059112
26cilium or flagellum-dependent cell motility (GO:0001539)3.72197739
27cell wall macromolecule catabolic process (GO:0016998)3.71865709
28cell wall macromolecule metabolic process (GO:0044036)3.71865709
29nodal signaling pathway (GO:0038092)3.68807202
30regulation of RNA export from nucleus (GO:0046831)3.53576491
31acrosome reaction (GO:0007340)3.52193973
32nuclear pore complex assembly (GO:0051292)3.49935989
33monoubiquitinated protein deubiquitination (GO:0035520)3.47013467
34anterior/posterior axis specification, embryo (GO:0008595)3.46804621
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.46643356
36spermatid development (GO:0007286)3.42440016
37positive regulation of chromosome segregation (GO:0051984)3.38134562
38branching involved in labyrinthine layer morphogenesis (GO:0060670)3.26158549
39primitive streak formation (GO:0090009)3.25715111
40metaphase plate congression (GO:0051310)3.22313483
41myelination in peripheral nervous system (GO:0022011)3.21624357
42peripheral nervous system axon ensheathment (GO:0032292)3.21624357
43regulation of type B pancreatic cell apoptotic process (GO:2000674)3.19690717
44protein localization to kinetochore (GO:0034501)3.19248354
45adhesion of symbiont to host cell (GO:0044650)3.17494562
46virion attachment to host cell (GO:0019062)3.17494562
47establishment of chromosome localization (GO:0051303)3.16753726
48chromosome organization involved in meiosis (GO:0070192)3.11303020
49nuclear pore organization (GO:0006999)3.11279365
50regulation of gastrulation (GO:0010470)3.06375366
51lymphangiogenesis (GO:0001946)3.05501850
52UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04871876
53notochord development (GO:0030903)3.03729354
54female gamete generation (GO:0007292)3.02022567
55mitotic sister chromatid cohesion (GO:0007064)3.01042540
56hippo signaling (GO:0035329)3.00754385
57microtubule severing (GO:0051013)2.97808699
58negative regulation of inclusion body assembly (GO:0090084)2.97704077
59oligosaccharide catabolic process (GO:0009313)2.97110606
60regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.95794266
61wound healing, spreading of epidermal cells (GO:0035313)2.95320799
62bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94629967
63genitalia morphogenesis (GO:0035112)2.93302603
64regulation of cardioblast differentiation (GO:0051890)2.92863476
65protein localization to endosome (GO:0036010)2.92414245
66microtubule polymerization or depolymerization (GO:0031109)2.90561053
67transcytosis (GO:0045056)2.90425240
68axonemal dynein complex assembly (GO:0070286)2.90243890
69fertilization (GO:0009566)2.90114641
70mitotic cytokinesis (GO:0000281)2.89446378
71regulation of cytokine secretion involved in immune response (GO:0002739)2.88658837
72mitotic G2/M transition checkpoint (GO:0044818)2.87847740
73retina vasculature morphogenesis in camera-type eye (GO:0061299)2.87277048
74negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.86367054
75regulation of centriole replication (GO:0046599)2.85706390
76DNA methylation involved in gamete generation (GO:0043046)2.85394122
77heterochromatin organization (GO:0070828)2.84435711
78cell adhesion mediated by integrin (GO:0033627)2.84378086
79single fertilization (GO:0007338)2.83357810
80meiotic cell cycle (GO:0051321)2.83291906
81endoderm development (GO:0007492)2.83025170
82regulation of mitotic spindle organization (GO:0060236)2.82939861
83astrocyte development (GO:0014002)2.81763053
84positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.81282117
85chondrocyte proliferation (GO:0035988)2.80343494
86regulation of nucleobase-containing compound transport (GO:0032239)2.79783090
87chromosome condensation (GO:0030261)2.79503073
88regulation of exit from mitosis (GO:0007096)2.78516691
89positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.78250688
90fatty acid elongation (GO:0030497)2.77496816
91platelet-derived growth factor receptor signaling pathway (GO:0048008)2.76882948
92protein localization to chromosome, centromeric region (GO:0071459)2.76257165
93regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.75911209
94cytoplasmic mRNA processing body assembly (GO:0033962)2.75904998
95spindle assembly involved in mitosis (GO:0090307)2.75813575
96epithelial cell-cell adhesion (GO:0090136)2.75545686
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74296206
98regulation of spindle organization (GO:0090224)2.72663637
99CENP-A containing nucleosome assembly (GO:0034080)2.71804635
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71232799
101asymmetric protein localization (GO:0008105)2.71126969
102negative regulation of neurotransmitter secretion (GO:0046929)2.71013836
103gap junction assembly (GO:0016264)2.70226531
104male meiosis I (GO:0007141)2.69869331
105response to lipoprotein particle (GO:0055094)2.69042958
106wound healing, spreading of cells (GO:0044319)2.67087288
107positive regulation vascular endothelial growth factor production (GO:0010575)2.66561890
108interleukin-6-mediated signaling pathway (GO:0070102)2.64628544
109nucleotide-sugar biosynthetic process (GO:0009226)2.64456069
110negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.63243515
111adhesion of symbiont to host (GO:0044406)2.63224372
112chromatin remodeling at centromere (GO:0031055)2.62555888
113DNA replication-dependent nucleosome organization (GO:0034723)2.60580578
114DNA replication-dependent nucleosome assembly (GO:0006335)2.60580578
115glomerular filtration (GO:0003094)2.60278850
116female gonad development (GO:0008585)2.59959228
117spermatogenesis (GO:0007283)2.59423262
118meiotic nuclear division (GO:0007126)2.59367946
119mitotic chromosome condensation (GO:0007076)2.59293055
120male gamete generation (GO:0048232)2.58843968
121motile cilium assembly (GO:0044458)2.58543358
122regulation of sister chromatid cohesion (GO:0007063)2.58484315
123pericardium development (GO:0060039)2.57646644
124gene silencing by RNA (GO:0031047)2.57253514
125epithelial cilium movement (GO:0003351)2.56503132
126positive regulation of hormone biosynthetic process (GO:0046886)2.54837055
127regulation of membrane protein ectodomain proteolysis (GO:0051043)2.54813281
128polarized epithelial cell differentiation (GO:0030859)2.54191404
129glomerular visceral epithelial cell development (GO:0072015)2.53499331
130positive regulation of catenin import into nucleus (GO:0035413)2.52772942
131regulation of vitamin D biosynthetic process (GO:0060556)2.52517506
132histone exchange (GO:0043486)2.52254183
133renal filtration (GO:0097205)2.52042208
134myelin maintenance (GO:0043217)2.51962275
135microtubule depolymerization (GO:0007019)2.51007198
136gamete generation (GO:0007276)2.50058384
137pyrimidine-containing compound transmembrane transport (GO:0072531)2.49612506
138substrate-dependent cell migration (GO:0006929)2.49288731
139regulation of keratinocyte proliferation (GO:0010837)2.49049472
140regulation of early endosome to late endosome transport (GO:2000641)2.48993540
141endodermal cell differentiation (GO:0035987)2.48873526
142sperm capacitation (GO:0048240)2.48449411
143regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47929936
144pore complex assembly (GO:0046931)2.47340979
145endothelial cell morphogenesis (GO:0001886)2.46647297
146regulation of heterotypic cell-cell adhesion (GO:0034114)2.45234475
147cortical actin cytoskeleton organization (GO:0030866)2.44948181
148apical protein localization (GO:0045176)2.44553004
149regulation of protein polyubiquitination (GO:1902914)2.44277131
150decidualization (GO:0046697)2.44261428
151negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.44224412
152microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.44154275
153endocardial cushion development (GO:0003197)2.43525883
154positive regulation of mitotic sister chromatid separation (GO:1901970)2.43292446
155positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.43292446
156regulation of retinoic acid receptor signaling pathway (GO:0048385)2.43201702
157mitotic G2 DNA damage checkpoint (GO:0007095)2.40465618
158regulation of SMAD protein import into nucleus (GO:0060390)2.39960928
159attachment of spindle microtubules to kinetochore (GO:0008608)2.39707474
160substrate adhesion-dependent cell spreading (GO:0034446)2.38644879
161L-ascorbic acid metabolic process (GO:0019852)2.37502071
162regulation of posttranscriptional gene silencing (GO:0060147)2.36162413
163regulation of gene silencing by miRNA (GO:0060964)2.36162413
164regulation of gene silencing by RNA (GO:0060966)2.36162413
165synapsis (GO:0007129)2.35931711
166positive regulation of cardiac muscle cell proliferation (GO:0060045)2.34470151
167regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.33871341
168regulation of tight junction assembly (GO:2000810)2.32689252
169regulation of female gonad development (GO:2000194)2.32492987
170sphingosine metabolic process (GO:0006670)2.31368467
171regulation of vascular endothelial growth factor production (GO:0010574)2.31118571
172anterior/posterior axis specification (GO:0009948)2.26952044
173somite rostral/caudal axis specification (GO:0032525)2.26035088
174endothelium development (GO:0003158)2.23530002
175L-alpha-amino acid transmembrane transport (GO:1902475)2.23082131
176regulation of histone H3-K9 methylation (GO:0051570)2.22823603
177positive regulation of glycoprotein biosynthetic process (GO:0010560)2.20950114
178plasma lipoprotein particle assembly (GO:0034377)2.20931472
179regulation of cell fate specification (GO:0042659)2.20739460
180cellular protein complex localization (GO:0034629)2.20480522
181regulation of vitamin metabolic process (GO:0030656)2.20043753
182regulation of non-canonical Wnt signaling pathway (GO:2000050)2.19385659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.27138719
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05691197
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.48610036
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.44387923
5AR_21909140_ChIP-Seq_LNCAP_Human3.05750730
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.75716110
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.68921584
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.39851486
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09911508
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09892582
11SALL4_18804426_ChIP-ChIP_XEN_Mouse2.09088269
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.08184175
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.05412151
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05270183
15E2F7_22180533_ChIP-Seq_HELA_Human2.01621343
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.00524968
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.96136436
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93929809
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93693970
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.92888302
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88754859
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.85133183
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81274788
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79459352
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77803835
26* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75966783
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74420628
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72915098
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71340024
30CJUN_26792858_Chip-Seq_BT549_Human1.69840606
31BRD4_25478319_ChIP-Seq_HGPS_Human1.65311638
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64461617
33* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.62779056
34* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60609328
35EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.60364888
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59691090
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58399615
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57219666
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57005323
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57005323
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57005323
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53755670
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53120881
44MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.53026330
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.49577839
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49290874
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47512649
48* FLI1_27457419_Chip-Seq_LIVER_Mouse1.46210318
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45355243
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43387827
51* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42942804
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42458799
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.39649909
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39090535
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.37548712
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35162388
57SMAD3_21741376_ChIP-Seq_HESCs_Human1.35015925
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34213572
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34213572
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33948112
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32528685
62NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30969652
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30619611
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30553742
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28804723
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28209157
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26945687
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26617304
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.26607201
70* CDX2_22108803_ChIP-Seq_LS180_Human1.25243076
71FUS_26573619_Chip-Seq_HEK293_Human1.25170505
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.24226735
73* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23980995
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23333317
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22804514
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22776899
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22626771
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.21526178
79AHR_22903824_ChIP-Seq_MCF-7_Human1.20492578
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19944765
81* P300_19829295_ChIP-Seq_ESCs_Human1.19260888
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.17723361
83* GATA4_25053715_ChIP-Seq_YYC3_Human1.17424288
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17036598
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16685416
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15551653
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15308519
88* EZH2_27294783_Chip-Seq_NPCs_Mouse1.14426499
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13290362
90TP63_23658742_ChIP-Seq_EP156T_Human1.12634649
91E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12486075
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12141457
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10785373
94* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10765938
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10544110
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.10500369
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09763055
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09040552
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08737769
100TP63_17297297_ChIP-ChIP_HaCaT_Human1.08523061
101TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08126716
102TP53_22127205_ChIP-Seq_IMR90_Human1.08038346
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07914764
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.07729739
105TP53_18474530_ChIP-ChIP_U2OS_Human1.07571313
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06567706
107SOX2_20726797_ChIP-Seq_SW620_Human1.06283689
108* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05630566
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.04838670
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.04838670
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04081809
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03825045
113CLOCK_20551151_ChIP-Seq_293T_Human1.02821550
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02525228
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02302185
116SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02215399
117SOX17_20123909_ChIP-Seq_XEN_Mouse1.01673599
118NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01326632
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.01223898
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.00752904
121ISL1_27105846_Chip-Seq_CPCs_Mouse1.00468916
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99575056
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99114617
124* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98926325
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.98854630
126IRF8_27001747_Chip-Seq_BMDM_Mouse0.98242422
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98158708
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.96777404
129ATF3_27146783_Chip-Seq_COLON_Human0.96565466
130* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96370465
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.96362699
132TP53_16413492_ChIP-PET_HCT116_Human0.94931263
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.94508037
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93714911
135* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93471683
136VDR_24787735_ChIP-Seq_THP-1_Human0.93292604
137SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93171015
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90767451
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90529269
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90432196
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90432196
142FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88218134
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87129970
144GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.86809579
145NFYB_21822215_ChIP-Seq_K562_Human0.85124752
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84287829
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84182581
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83417997
149NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83356775
150* GF1B_26923725_Chip-Seq_HPCs_Mouse0.81919034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.40972738
2MP0005410_abnormal_fertilization4.37609827
3MP0005623_abnormal_meninges_morphology3.81271290
4MP0002139_abnormal_hepatobiliary_system3.72943794
5MP0006292_abnormal_olfactory_placode3.33745640
6MP0003950_abnormal_plasma_membrane3.27761307
7MP0004272_abnormal_basement_membrane3.23492586
8MP0002254_reproductive_system_inflammat2.97753743
9MP0002138_abnormal_hepatobiliary_system2.88812682
10MP0003705_abnormal_hypodermis_morpholog2.88385195
11MP0008004_abnormal_stomach_pH2.32210975
12MP0000733_abnormal_muscle_development2.11687636
13MP0005503_abnormal_tendon_morphology2.06032218
14MP0009384_cardiac_valve_regurgitation2.03128337
15MP0010352_gastrointestinal_tract_polyps2.02736802
16MP0005275_abnormal_skin_tensile2.01479304
17MP0008877_abnormal_DNA_methylation1.96354595
18MP0005257_abnormal_intraocular_pressure1.95339536
19MP0003195_calcinosis1.93108335
20MP0003091_abnormal_cell_migration1.89655312
21MP0000920_abnormal_myelination1.89471683
22MP0003937_abnormal_limbs/digits/tail_de1.89234694
23MP0003693_abnormal_embryo_hatching1.88219559
24MP0001929_abnormal_gametogenesis1.80255469
25MP0003303_peritoneal_inflammation1.79437832
26MP0009840_abnormal_foam_cell1.77146513
27MP0010030_abnormal_orbit_morphology1.76451971
28MP0010234_abnormal_vibrissa_follicle1.72054891
29MP0003279_aneurysm1.59868283
30MP0001730_embryonic_growth_arrest1.59524452
31MP0003698_abnormal_male_reproductive1.55911693
32MP0010368_abnormal_lymphatic_system1.54272885
33MP0002796_impaired_skin_barrier1.54167134
34MP0005360_urolithiasis1.53260418
35MP0002295_abnormal_pulmonary_circulatio1.52118167
36MP0001879_abnormal_lymphatic_vessel1.51291116
37MP0002653_abnormal_ependyma_morphology1.51259844
38MP0001299_abnormal_eye_distance/1.46141921
39MP0003566_abnormal_cell_adhesion1.43349823
40MP0002210_abnormal_sex_determination1.42236266
41MP0001915_intracranial_hemorrhage1.37849783
42MP0001958_emphysema1.37263317
43MP0009250_abnormal_appendicular_skeleto1.36177614
44MP0005023_abnormal_wound_healing1.33056153
45MP0005365_abnormal_bile_salt1.32783211
46MP0002084_abnormal_developmental_patter1.29917799
47MP0002085_abnormal_embryonic_tissue1.29806385
48MP0004185_abnormal_adipocyte_glucose1.29009555
49MP0003385_abnormal_body_wall1.28789122
50MP0010678_abnormal_skin_adnexa1.27339937
51MP0004084_abnormal_cardiac_muscle1.26650211
52MP0004233_abnormal_muscle_weight1.25090475
53MP0000537_abnormal_urethra_morphology1.22708779
54MP0003718_maternal_effect1.21996362
55MP0001672_abnormal_embryogenesis/_devel1.21827597
56MP0005380_embryogenesis_phenotype1.21827597
57MP0008932_abnormal_embryonic_tissue1.20790152
58MP0001145_abnormal_male_reproductive1.19931373
59MP0000462_abnormal_digestive_system1.19789797
60MP0001697_abnormal_embryo_size1.19639486
61MP0004957_abnormal_blastocyst_morpholog1.19616277
62MP0003984_embryonic_growth_retardation1.18829975
63MP0006054_spinal_hemorrhage1.18780009
64MP0003077_abnormal_cell_cycle1.18607202
65MP0002233_abnormal_nose_morphology1.16941670
66MP0003755_abnormal_palate_morphology1.16922872
67MP0003868_abnormal_feces_composition1.16811768
68MP0000432_abnormal_head_morphology1.15731569
69MP0002925_abnormal_cardiovascular_devel1.13973763
70MP0002088_abnormal_embryonic_growth/wei1.13631339
71MP0004134_abnormal_chest_morphology1.12068234
72MP0008057_abnormal_DNA_replication1.11215880
73MP0000383_abnormal_hair_follicle1.11188024
74MP0004197_abnormal_fetal_growth/weight/1.10872849
75MP0002282_abnormal_trachea_morphology1.10236578
76MP0000653_abnormal_sex_gland1.09729282
77MP0004264_abnormal_extraembryonic_tissu1.08300514
78MP0005508_abnormal_skeleton_morphology1.08206892
79MP0000767_abnormal_smooth_muscle1.06539754
80MP0009053_abnormal_anal_canal1.06283960
81MP0005197_abnormal_uvea_morphology1.05348591
82MP0002161_abnormal_fertility/fecundity1.05253598
83MP0003111_abnormal_nucleus_morphology1.05087224
84MP0001614_abnormal_blood_vessel1.05044639
85MP0000428_abnormal_craniofacial_morphol1.04246951
86MP0005076_abnormal_cell_differentiation1.04241978
87MP0002086_abnormal_extraembryonic_tissu1.01925080
88MP0003935_abnormal_craniofacial_develop1.01645332
89MP0001849_ear_inflammation1.01605310
90MP0003941_abnormal_skin_development1.00492914
91MP0001727_abnormal_embryo_implantation1.00414683
92MP0000350_abnormal_cell_proliferation0.99656397
93MP0001666_abnormal_nutrient_absorption0.99356778
94MP0000534_abnormal_ureter_morphology0.99199266
95MP0003890_abnormal_embryonic-extraembry0.98731792
96MP0006082_CNS_inflammation0.98560678
97MP0005085_abnormal_gallbladder_physiolo0.98273085
98MP0000762_abnormal_tongue_morphology0.97888391
99MP0004036_abnormal_muscle_relaxation0.97577761
100MP0005058_abnormal_lysosome_morphology0.96991317
101MP0001286_abnormal_eye_development0.96876289
102MP0003115_abnormal_respiratory_system0.96732874
103MP0006138_congestive_heart_failure0.95179066
104MP0008007_abnormal_cellular_replicative0.92048245
105MP0000750_abnormal_muscle_regeneration0.90249553
106MP0005395_other_phenotype0.90169097
107MP0004087_abnormal_muscle_fiber0.90044176
108MP0001293_anophthalmia0.89768335
109MP0005501_abnormal_skin_physiology0.88567541
110MP0002108_abnormal_muscle_morphology0.88554311
111MP0001216_abnormal_epidermal_layer0.88425109
112MP0003828_pulmonary_edema0.88208157
113MP0002896_abnormal_bone_mineralization0.87357969
114MP0008789_abnormal_olfactory_epithelium0.87057811
115MP0005647_abnormal_sex_gland0.85898672
116MP0010630_abnormal_cardiac_muscle0.85076424
117MP0003690_abnormal_glial_cell0.84930728
118MP0010307_abnormal_tumor_latency0.84376235
119MP0003300_gastrointestinal_ulcer0.83344906
120MP0002092_abnormal_eye_morphology0.83343609
121MP0002998_abnormal_bone_remodeling0.82548357
122MP0000647_abnormal_sebaceous_gland0.82336474
123MP0002697_abnormal_eye_size0.82167231
124MP0010094_abnormal_chromosome_stability0.81317873
125MP0001348_abnormal_lacrimal_gland0.80246741
126MP0003448_altered_tumor_morphology0.80028072
127MP0005164_abnormal_response_to0.80002550
128MP0002932_abnormal_joint_morphology0.79460338
129MP0003453_abnormal_keratinocyte_physiol0.79432439
130MP0003699_abnormal_female_reproductive0.79003074
131MP0002102_abnormal_ear_morphology0.78764204
132MP0002080_prenatal_lethality0.78265692
133MP0002128_abnormal_blood_circulation0.77717711
134MP0001542_abnormal_bone_strength0.76933028
135MP0003123_paternal_imprinting0.75920021
136MP0005409_darkened_coat_color0.74993640
137MP0002060_abnormal_skin_morphology0.74217294
138MP0005394_taste/olfaction_phenotype0.70173896
139MP0005499_abnormal_olfactory_system0.70173896
140MP0005248_abnormal_Harderian_gland0.69796745
141MP0003119_abnormal_digestive_system0.68806117
142MP0003186_abnormal_redox_activity0.66753666
143MP0000569_abnormal_digit_pigmentation0.66717147
144MP0002168_other_aberrant_phenotype0.64915991

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.31029441
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.54408828
3Protrusio acetabuli (HP:0003179)4.39427626
4Shallow orbits (HP:0000586)4.07222090
5Intrahepatic cholestasis (HP:0001406)3.78050330
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.59952872
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.59952872
8Nuclear cataract (HP:0100018)3.54363749
9Absent/shortened dynein arms (HP:0200106)3.47125100
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.47125100
11Septo-optic dysplasia (HP:0100842)3.33534405
12Hypophosphatemic rickets (HP:0004912)3.32322841
13Sensory axonal neuropathy (HP:0003390)3.27027804
14Hematochezia (HP:0002573)3.26741162
15Abnormality of dentin (HP:0010299)3.22683534
16Osteomalacia (HP:0002749)3.17851138
17Hyperactive renin-angiotensin system (HP:0000841)3.13229814
18Conjunctival telangiectasia (HP:0000524)3.13114138
19Abnormality of the vasculature of the conjunctiva (HP:0008054)3.11308858
20Supernumerary spleens (HP:0009799)3.04269572
21Metaphyseal irregularity (HP:0003025)3.03340313
22Aortic dissection (HP:0002647)2.96113879
23Vacuolated lymphocytes (HP:0001922)2.94774370
24Broad metatarsal (HP:0001783)2.93641598
25Male infertility (HP:0003251)2.90035061
26Tetraparesis (HP:0002273)2.86093439
27Muscle fiber splitting (HP:0003555)2.81427658
28Myocardial infarction (HP:0001658)2.79205322
29Peritonitis (HP:0002586)2.77898381
30Hyporeflexia of lower limbs (HP:0002600)2.77402703
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74022187
32Malignant gastrointestinal tract tumors (HP:0006749)2.69830828
33Gastrointestinal carcinoma (HP:0002672)2.69830828
34Capillary hemangiomas (HP:0005306)2.66595051
35Disinhibition (HP:0000734)2.65256409
36Insidious onset (HP:0003587)2.61960218
37Termporal pattern (HP:0011008)2.61960218
38Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.57436542
39Bell-shaped thorax (HP:0001591)2.57281210
40Rickets (HP:0002748)2.57202586
41Ankle contracture (HP:0006466)2.51560222
42Atrophic scars (HP:0001075)2.46750829
43Oligodactyly (hands) (HP:0001180)2.44389609
44Abnormality of the corticospinal tract (HP:0002492)2.38391915
45Soft skin (HP:0000977)2.36701046
46Esophageal varix (HP:0002040)2.36693773
47Flat acetabular roof (HP:0003180)2.36246414
48Bladder diverticulum (HP:0000015)2.35399943
49Leiomyosarcoma (HP:0100243)2.33659995
50Uterine leiomyosarcoma (HP:0002891)2.33659995
51Loss of speech (HP:0002371)2.33544843
52Papillary thyroid carcinoma (HP:0002895)2.32589089
53Ulnar bowing (HP:0003031)2.31876582
54Transitional cell carcinoma of the bladder (HP:0006740)2.31389792
55Abnormal tarsal ossification (HP:0008369)2.30613224
56Round ear (HP:0100830)2.30416787
57Biliary tract neoplasm (HP:0100574)2.30156571
58Fused cervical vertebrae (HP:0002949)2.27837614
59Microglossia (HP:0000171)2.21893700
60Wormian bones (HP:0002645)2.21380151
61Buphthalmos (HP:0000557)2.21333975
62Malnutrition (HP:0004395)2.19689460
63Coronal craniosynostosis (HP:0004440)2.19005037
64Abdominal situs inversus (HP:0003363)2.17292573
65Abnormality of abdominal situs (HP:0011620)2.17292573
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.17147078
67Osteolytic defects of the hand bones (HP:0009699)2.17147078
68Genu recurvatum (HP:0002816)2.17132938
69Cerebral aneurysm (HP:0004944)2.17036184
70Aortic aneurysm (HP:0004942)2.16877310
71Abnormality of carpal bone ossification (HP:0006257)2.16171923
72Abnormal respiratory motile cilium physiology (HP:0012261)2.14932890
73Short 4th metacarpal (HP:0010044)2.14831600
74Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14831600
75Decreased circulating renin level (HP:0003351)2.14805660
76Uterine neoplasm (HP:0010784)2.14369333
77Hydroxyprolinuria (HP:0003080)2.12263862
78Abnormality of proline metabolism (HP:0010907)2.12263862
79Facial hemangioma (HP:0000329)2.10720479
80Difficulty climbing stairs (HP:0003551)2.10402391
81Bladder neoplasm (HP:0009725)2.08929522
82Bladder carcinoma (HP:0002862)2.08929522
83Short humerus (HP:0005792)2.08886173
84Spinal rigidity (HP:0003306)2.06560680
85Maternal diabetes (HP:0009800)2.05282478
86Difficulty running (HP:0009046)2.05172919
87Cerebral hypomyelination (HP:0006808)2.04486051
88Mitral valve prolapse (HP:0001634)2.00688352
89Short nail (HP:0001799)2.00662732
90Increased circulating renin level (HP:0000848)1.99616094
91Progressive inability to walk (HP:0002505)1.99414757
92Abnormality of the nasal septum (HP:0000419)1.99394452
93Aplasia/hypoplasia of the humerus (HP:0006507)1.99040202
94Abnormality of liposaccharide metabolism (HP:0010968)1.98049696
95Abnormality of glycosphingolipid metabolism (HP:0004343)1.98049696
96Abnormality of glycolipid metabolism (HP:0010969)1.98049696
97Chronic bronchitis (HP:0004469)1.96219071
98Bifid tongue (HP:0010297)1.95861224
99Proximal tubulopathy (HP:0000114)1.95301608
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.93932524
101Relative macrocephaly (HP:0004482)1.93922985
102Abnormal foot bone ossification (HP:0010675)1.93730540
103Apathy (HP:0000741)1.90774049
104Median cleft lip (HP:0000161)1.89605429
105Cortical dysplasia (HP:0002539)1.89297504
106Tubular atrophy (HP:0000092)1.89002081
107Pulmonic stenosis (HP:0001642)1.88989775
108Hyperkalemia (HP:0002153)1.88800765
109Absent eyebrow (HP:0002223)1.88362326
110Cardiovascular calcification (HP:0011915)1.87622623
111Infertility (HP:0000789)1.87346818
112Absent septum pellucidum (HP:0001331)1.87014253
113Chromsome breakage (HP:0040012)1.86506380
114Renal cell carcinoma (HP:0005584)1.86100569
115Abnormality of methionine metabolism (HP:0010901)1.85467049
116Parakeratosis (HP:0001036)1.85362732
117Neurofibrillary tangles (HP:0002185)1.84368613
118Lip pit (HP:0100267)1.84245626
119Esophageal atresia (HP:0002032)1.84196309
120Abnormal biliary tract morphology (HP:0012440)1.84051946
121Adrenal hypoplasia (HP:0000835)1.83703897
122Glomerulonephritis (HP:0000099)1.83695611
123Anal stenosis (HP:0002025)1.83587669
124Wrist flexion contracture (HP:0001239)1.83544985
125Hypoalphalipoproteinemia (HP:0003233)1.83384814
126Oligodactyly (HP:0012165)1.83145296
127Abnormal lung lobation (HP:0002101)1.82945555
128Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81261026
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81196806
130Blue sclerae (HP:0000592)1.80228243
131Thin bony cortex (HP:0002753)1.79811697
132Diminished motivation (HP:0000745)1.79675287
133Scapular winging (HP:0003691)1.79428149
134Vascular calcification (HP:0004934)1.78988040
135Increased connective tissue (HP:0009025)1.77992343
136Systemic lupus erythematosus (HP:0002725)1.77894330
137Tracheal stenosis (HP:0002777)1.77755400
138Syringomyelia (HP:0003396)1.77033587
139Spinal cord lesions (HP:0100561)1.77033587
140Curly hair (HP:0002212)1.76092095
141Short hallux (HP:0010109)1.75328114
142Premature skin wrinkling (HP:0100678)1.74029009
143Rhizomelia (HP:0008905)1.73774658
144Ectopic kidney (HP:0000086)1.73765593
145Arterial tortuosity (HP:0005116)1.73742346
146Abnormal respiratory epithelium morphology (HP:0012253)1.73738006
147Abnormal respiratory motile cilium morphology (HP:0005938)1.73738006
148Preaxial foot polydactyly (HP:0001841)1.73190377
149Deep venous thrombosis (HP:0002625)1.73015814
150Nephroblastoma (Wilms tumor) (HP:0002667)1.72283487
151Vascular tortuosity (HP:0004948)1.72230421
152Deviation of the hallux (HP:0010051)1.72132949
153Abnormal delivery (HP:0001787)1.71971982
154Abnormality of the fetal cardiovascular system (HP:0010948)1.71582797
155Abnormal umbilical cord blood vessels (HP:0011403)1.71582797
156Single umbilical artery (HP:0001195)1.71582797
157Colon cancer (HP:0003003)1.71375824
158Nausea (HP:0002018)1.70556882
159Abnormality of the 4th metacarpal (HP:0010012)1.69926541
160Abnormality of the peritoneum (HP:0002585)1.69816570
161Abnormality of the calcaneus (HP:0008364)1.69666944
162Hypoplastic pelvis (HP:0008839)1.69582336
163Stenosis of the external auditory canal (HP:0000402)1.69053154
164Conjugated hyperbilirubinemia (HP:0002908)1.68962478
165Rhinitis (HP:0012384)1.67936294
166Dilatation of the ascending aorta (HP:0005111)1.66915548
167Rhabdomyosarcoma (HP:0002859)1.66727090
168Hallux valgus (HP:0001822)1.66443672
169Abnormal hand bone ossification (HP:0010660)1.65699052
170Fat malabsorption (HP:0002630)1.65452631
171Cerebral inclusion bodies (HP:0100314)1.65213553
172Broad ribs (HP:0000885)1.64494127
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64057934
174Embryonal renal neoplasm (HP:0011794)1.63810397
175Hypoplasia of the iris (HP:0007676)1.63508474
176Abnormality of chloride homeostasis (HP:0011422)1.63255245
177Hyperextensible skin (HP:0000974)1.62722631
178Spondylolisthesis (HP:0003302)1.62411127
179Abnormal ossification of hand bones (HP:0005921)1.62373450
180Chin dimple (HP:0010751)1.62188551
181Hyperaldosteronism (HP:0000859)1.62181978
182Gowers sign (HP:0003391)1.61301349
183Infantile muscular hypotonia (HP:0008947)1.61229233
184Selective tooth agenesis (HP:0001592)1.60229414
185Breast hypoplasia (HP:0003187)1.60185219
186Calcaneovalgus deformity (HP:0001848)1.59983136
187Ileus (HP:0002595)1.59927962
188Abnormality of the umbilical cord (HP:0010881)1.57988230
189Limited elbow extension (HP:0001377)1.56345166
190Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.55862036
191Aplasia/Hypoplasia of the hallux (HP:0008362)1.55503866
192Hypoplastic ischia (HP:0003175)1.54534994
193Onion bulb formation (HP:0003383)1.54279490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.39475511
2TNIK3.98937947
3MAP3K93.79668064
4PDK23.39976220
5ICK3.16016549
6LATS13.04866609
7PDK42.82111173
8PDK32.82111173
9STK242.79184763
10PBK2.65273367
11EPHB12.53334957
12ACVR1B2.36550003
13IRAK32.35702504
14MET2.25551329
15TESK12.09376915
16PRKD32.07191138
17WNK42.02289802
18NLK2.00184684
19STK31.89566207
20LATS21.86598741
21MAP3K131.82870724
22ARAF1.77810671
23DDR21.76898768
24TTN1.74712434
25OXSR11.69612947
26PTK2B1.64257340
27EIF2AK31.59214293
28TGFBR21.54633068
29STK101.53295701
30TTK1.52677850
31WNK11.51026408
32TYRO31.50412223
33MST41.49442997
34MOS1.49276834
35DMPK1.47320631
36CDK121.39071069
37PAK21.36060286
38BCR1.35605422
39RIPK11.35492065
40PAK61.34930094
41NEK21.32552374
42PNCK1.31494832
43TESK21.28325923
44EPHA21.27871993
45CDC71.26206933
46BMX1.25514753
47MELK1.20237186
48ERBB41.18518947
49MKNK21.17950479
50DYRK31.17879398
51FGFR21.17803847
52LIMK11.17365341
53CASK1.15129645
54TRIM281.13865227
55NUAK11.09476765
56PLK41.09469102
57PAK31.05780100
58BRAF1.04963407
59TAOK11.03958408
60PDGFRB1.01837273
61STK38L1.01284892
62MAP3K81.01059680
63PAK10.97453165
64MKNK10.97375669
65KSR10.96875448
66TGFBR10.95647553
67NEK60.95421774
68MAP3K120.95071712
69MTOR0.93051328
70MATK0.92138134
71PDGFRA0.90672498
72PTK20.90026325
73ROCK20.89088455
74BMPR1B0.88260226
75MAP3K140.87898025
76CAMK1G0.85934247
77BRSK20.84737064
78TSSK60.83605405
79CSNK1A1L0.83588979
80FGR0.82310722
81CHEK20.82137378
82TIE10.78661961
83PAK40.78510230
84TRIB30.78164298
85TRPM70.77662868
86IRAK40.77511835
87YES10.76941633
88EPHB20.76107951
89BUB10.75191353
90KDR0.75186576
91PKN10.73116530
92NEK10.70805855
93CSNK1G10.70442284
94MAP3K100.69469720
95LRRK20.69315580
96CHEK10.67623885
97CAMK1D0.65911854
98CSNK1G30.65600862
99FGFR10.60470888
100FER0.60033149
101PLK10.59805986
102CDK140.59803967
103KSR20.59754552
104ABL20.59684776
105MAPKAPK50.58065677
106PIK3CA0.57850954
107MST1R0.56836761
108PKN20.52855348
109CDK60.52175429
110ROCK10.50747869
111TAOK20.50011235
112GRK70.49398890
113NEK90.47747110
114DYRK20.47445421
115AURKB0.46990804
116CDK150.46828790
117IRAK20.46802887
118STK40.46499802
119BRD40.46428989
120WEE10.45829817
121ALK0.45523145
122CHUK0.44858871
123RPS6KA40.44542878
124EGFR0.43706260
125CSNK1G20.42685286
126RPS6KA50.42120404
127CLK10.41921782
128CSNK1D0.41052565
129MAP3K30.40020991
130INSR0.39978755
131PRKG20.39959502
132CDC42BPA0.39549133
133EIF2AK20.39030618
134MAP3K50.38959408
135PDPK10.38780674
136CDK11A0.38472701
137PRKD10.38419259
138PLK30.38187084
139CDK180.36926563
140ILK0.36044999
141GSK3A0.35145764
142ZAK0.34983452
143CDK90.34920823
144MAP3K10.33738898
145MYLK0.31398610
146PRKCI0.30604710
147JAK30.27498028

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.53002061
2Steroid biosynthesis_Homo sapiens_hsa001002.61105421
3ECM-receptor interaction_Homo sapiens_hsa045122.58665534
4Ether lipid metabolism_Homo sapiens_hsa005652.25631211
5Complement and coagulation cascades_Homo sapiens_hsa046102.19759290
6Tight junction_Homo sapiens_hsa045302.16597010
7Adherens junction_Homo sapiens_hsa045202.10821268
8Vitamin B6 metabolism_Homo sapiens_hsa007502.06613493
9Basal transcription factors_Homo sapiens_hsa030222.03476927
10Hippo signaling pathway_Homo sapiens_hsa043902.01998069
11Dorso-ventral axis formation_Homo sapiens_hsa043202.01199494
12Thyroid cancer_Homo sapiens_hsa052162.00772352
13Focal adhesion_Homo sapiens_hsa045102.00284851
14Cell cycle_Homo sapiens_hsa041101.99951581
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.95160090
16Renal cell carcinoma_Homo sapiens_hsa052111.92339445
17TGF-beta signaling pathway_Homo sapiens_hsa043501.87473861
18MicroRNAs in cancer_Homo sapiens_hsa052061.83760306
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80170549
20RNA transport_Homo sapiens_hsa030131.74948298
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.72827410
22Proteoglycans in cancer_Homo sapiens_hsa052051.70661689
23Small cell lung cancer_Homo sapiens_hsa052221.67126971
24Oocyte meiosis_Homo sapiens_hsa041141.59577157
25Linoleic acid metabolism_Homo sapiens_hsa005911.58606204
26Axon guidance_Homo sapiens_hsa043601.58364145
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.56428585
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53970764
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.48103441
30Malaria_Homo sapiens_hsa051441.37047982
31Shigellosis_Homo sapiens_hsa051311.36741353
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33913576
33Lysosome_Homo sapiens_hsa041421.33009272
34Hedgehog signaling pathway_Homo sapiens_hsa043401.32861661
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31306368
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.28876205
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27754860
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27753745
39Caffeine metabolism_Homo sapiens_hsa002321.26201791
40Basal cell carcinoma_Homo sapiens_hsa052171.24758778
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23821365
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22876994
43p53 signaling pathway_Homo sapiens_hsa041151.21431261
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21251203
45Vitamin digestion and absorption_Homo sapiens_hsa049771.19513110
46Pertussis_Homo sapiens_hsa051331.18444011
47Amoebiasis_Homo sapiens_hsa051461.18089638
48African trypanosomiasis_Homo sapiens_hsa051431.16708461
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15862245
50Endocytosis_Homo sapiens_hsa041441.14383277
51mRNA surveillance pathway_Homo sapiens_hsa030151.12731938
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11949909
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11381886
54PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09880517
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09414710
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08360748
57Other glycan degradation_Homo sapiens_hsa005111.06674301
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05868885
59Selenocompound metabolism_Homo sapiens_hsa004501.04016441
60Viral myocarditis_Homo sapiens_hsa054161.03760296
61Legionellosis_Homo sapiens_hsa051341.03214884
62Prostate cancer_Homo sapiens_hsa052150.99710674
63VEGF signaling pathway_Homo sapiens_hsa043700.97975028
64Mismatch repair_Homo sapiens_hsa034300.97916799
65Bladder cancer_Homo sapiens_hsa052190.95418986
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95062989
67Dilated cardiomyopathy_Homo sapiens_hsa054140.94636237
68PPAR signaling pathway_Homo sapiens_hsa033200.94081814
69Sulfur metabolism_Homo sapiens_hsa009200.93387902
70Viral carcinogenesis_Homo sapiens_hsa052030.93029478
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92290833
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90532512
73Salmonella infection_Homo sapiens_hsa051320.89941682
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88364662
75Ras signaling pathway_Homo sapiens_hsa040140.87989053
76Pathways in cancer_Homo sapiens_hsa052000.87954400
77Protein digestion and absorption_Homo sapiens_hsa049740.85974283
78Ovarian steroidogenesis_Homo sapiens_hsa049130.85863761
79Sphingolipid metabolism_Homo sapiens_hsa006000.85539943
80Wnt signaling pathway_Homo sapiens_hsa043100.85259606
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85149259
82Notch signaling pathway_Homo sapiens_hsa043300.83331300
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82840769
84Fatty acid elongation_Homo sapiens_hsa000620.82602165
85Chronic myeloid leukemia_Homo sapiens_hsa052200.82439057
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.82103308
87Pancreatic cancer_Homo sapiens_hsa052120.81455017
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.81452476
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80064890
90RNA polymerase_Homo sapiens_hsa030200.79923413
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79195833
92Influenza A_Homo sapiens_hsa051640.77262843
93Rap1 signaling pathway_Homo sapiens_hsa040150.75762136
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.75211543
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74654309
96Hepatitis B_Homo sapiens_hsa051610.73038875
97Circadian rhythm_Homo sapiens_hsa047100.71658457
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.71075059
99Platelet activation_Homo sapiens_hsa046110.70315751
100Osteoclast differentiation_Homo sapiens_hsa043800.70235665
101RNA degradation_Homo sapiens_hsa030180.69816200
102Fanconi anemia pathway_Homo sapiens_hsa034600.69658208
103HTLV-I infection_Homo sapiens_hsa051660.69335500
104Folate biosynthesis_Homo sapiens_hsa007900.68766184
105Starch and sucrose metabolism_Homo sapiens_hsa005000.67699014
106Glutathione metabolism_Homo sapiens_hsa004800.67160772
107Fat digestion and absorption_Homo sapiens_hsa049750.67134140
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66660232
109Spliceosome_Homo sapiens_hsa030400.65854329
110Hepatitis C_Homo sapiens_hsa051600.65763196
111MAPK signaling pathway_Homo sapiens_hsa040100.64089156
112Epstein-Barr virus infection_Homo sapiens_hsa051690.63920085
113Arginine biosynthesis_Homo sapiens_hsa002200.63365572
114FoxO signaling pathway_Homo sapiens_hsa040680.60741044
115ErbB signaling pathway_Homo sapiens_hsa040120.60569327
116Toxoplasmosis_Homo sapiens_hsa051450.59751448
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57859053
118Prion diseases_Homo sapiens_hsa050200.57831823
119Arginine and proline metabolism_Homo sapiens_hsa003300.57070466
120Systemic lupus erythematosus_Homo sapiens_hsa053220.55620580
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55005750
122Melanoma_Homo sapiens_hsa052180.53858707
123Retinol metabolism_Homo sapiens_hsa008300.53311878
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53223656
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.52663421
126Gap junction_Homo sapiens_hsa045400.52264860
127Endometrial cancer_Homo sapiens_hsa052130.51298524
128Arachidonic acid metabolism_Homo sapiens_hsa005900.51119426
129Galactose metabolism_Homo sapiens_hsa000520.51077846
130Fatty acid biosynthesis_Homo sapiens_hsa000610.49070198
131Homologous recombination_Homo sapiens_hsa034400.48055032
132Lysine degradation_Homo sapiens_hsa003100.47550979
133Staphylococcus aureus infection_Homo sapiens_hsa051500.47484918
134Proteasome_Homo sapiens_hsa030500.46976672
135Tryptophan metabolism_Homo sapiens_hsa003800.46467743
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46191557
137Apoptosis_Homo sapiens_hsa042100.45776504
138Non-homologous end-joining_Homo sapiens_hsa034500.45362383
139Estrogen signaling pathway_Homo sapiens_hsa049150.44775776
140TNF signaling pathway_Homo sapiens_hsa046680.44742268
141HIF-1 signaling pathway_Homo sapiens_hsa040660.44680078
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.44383108
143Mineral absorption_Homo sapiens_hsa049780.42757288
144Colorectal cancer_Homo sapiens_hsa052100.42021560
145Choline metabolism in cancer_Homo sapiens_hsa052310.41506490
146Nucleotide excision repair_Homo sapiens_hsa034200.39521154
147Phagosome_Homo sapiens_hsa041450.39399955
148Glioma_Homo sapiens_hsa052140.36065047

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