ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	6.36388496
2	acrosome reaction (GO:0007340)	5.79200151
3	cilium or flagellum-dependent cell motility (GO:0001539)	5.76595247
4	axonemal dynein complex assembly (GO:0070286)	5.15285268
5	fusion of sperm to egg plasma membrane (GO:0007342)	5.15203232
6	piRNA metabolic process (GO:0034587)	5.08544066
7	epithelial cilium movement (GO:0003351)	4.93563271
8	DNA methylation involved in gamete generation (GO:0043046)	4.79974942
9	motile cilium assembly (GO:0044458)	4.72879801
10	cilium movement (GO:0003341)	4.65895458
11	microtubule depolymerization (GO:0007019)	4.63497622
12	establishment of protein localization to Golgi (GO:0072600)	4.60635122
13	cellular ketone body metabolic process (GO:0046950)	4.59057947
14	microtubule polymerization or depolymerization (GO:0031109)	4.57811458
15	ketone body metabolic process (GO:1902224)	4.53868453
16	multicellular organism reproduction (GO:0032504)	4.45217037
17	sperm-egg recognition (GO:0035036)	4.39614293
18	centriole replication (GO:0007099)	4.35397622
19	protein targeting to Golgi (GO:0000042)	4.21352454
20	response to pheromone (GO:0019236)	4.19964007
21	centriole assembly (GO:0098534)	4.17028130
22	protein polyglutamylation (GO:0018095)	4.11621820
23	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	4.03783522
24	seminiferous tubule development (GO:0072520)	4.02072099
25	spermatid development (GO:0007286)	4.01046804
26	male meiosis (GO:0007140)	3.87891469
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.87317680
28	axoneme assembly (GO:0035082)	3.86779634
29	rRNA methylation (GO:0031167)	3.85080789
30	protein localization to Golgi apparatus (GO:0034067)	3.85073525
31	plasma membrane fusion (GO:0045026)	3.83940181
32	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.82376347
33	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.79635398
34	binding of sperm to zona pellucida (GO:0007339)	3.78954540
35	indolalkylamine metabolic process (GO:0006586)	3.73270434
36	regulation of cilium movement (GO:0003352)	3.62446445
37	cell wall macromolecule metabolic process (GO:0044036)	3.59323458
38	regulation of meiosis I (GO:0060631)	3.55309082
39	cell-cell recognition (GO:0009988)	3.54105023
40	cell wall macromolecule catabolic process (GO:0016998)	3.46160172
41	amino acid salvage (GO:0043102)	3.39002222
42	L-methionine salvage (GO:0071267)	3.39002222
43	L-methionine biosynthetic process (GO:0071265)	3.39002222
44	protein localization to cilium (GO:0061512)	3.38295133
45	sphingoid metabolic process (GO:0046519)	3.34212710
46	regulation of centriole replication (GO:0046599)	3.32929451
47	indole-containing compound catabolic process (GO:0042436)	3.32242295
48	indolalkylamine catabolic process (GO:0046218)	3.32242295
49	tryptophan catabolic process (GO:0006569)	3.32242295
50	calcium ion-dependent exocytosis (GO:0017156)	3.30545715
51	single fertilization (GO:0007338)	3.30462270
52	behavioral response to ethanol (GO:0048149)	3.30272743
53	sensory perception of smell (GO:0007608)	3.26639128
54	cilium organization (GO:0044782)	3.25360970
55	rRNA modification (GO:0000154)	3.25357128
56	cilium assembly (GO:0042384)	3.23607459
57	male meiosis I (GO:0007141)	3.23487842
58	spermatogenesis (GO:0007283)	3.23347811
59	male gamete generation (GO:0048232)	3.23254580
60	DNA double-strand break processing (GO:0000729)	3.20080297
61	left/right axis specification (GO:0070986)	3.16556231
62	methionine biosynthetic process (GO:0009086)	3.14745886
63	microtubule nucleation (GO:0007020)	3.11657534
64	microtubule severing (GO:0051013)	3.07419310
65	positive regulation of developmental pigmentation (GO:0048087)	3.06530570
66	photoreceptor cell maintenance (GO:0045494)	3.06384701
67	tryptophan metabolic process (GO:0006568)	3.03970148
68	detection of light stimulus involved in sensory perception (GO:0050962)	3.01179094
69	detection of light stimulus involved in visual perception (GO:0050908)	3.01179094
70	reproduction (GO:0000003)	3.00248332
71	methionine metabolic process (GO:0006555)	2.99384852
72	gamete generation (GO:0007276)	2.98907334
73	fertilization (GO:0009566)	2.98376000
74	acrosome assembly (GO:0001675)	2.97716151
75	neural tube formation (GO:0001841)	2.95347590
76	synapsis (GO:0007129)	2.90138797
77	peptidyl-threonine dephosphorylation (GO:0035970)	2.86482828
78	cellular biogenic amine catabolic process (GO:0042402)	2.86439288
79	amine catabolic process (GO:0009310)	2.86439288
80	ubiquinone biosynthetic process (GO:0006744)	2.85240722
81	meiotic nuclear division (GO:0007126)	2.84943806
82	regulation of pigment cell differentiation (GO:0050932)	2.84712237
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.80170359
84	sphingosine metabolic process (GO:0006670)	2.79577585
85	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.79275622
86	kynurenine metabolic process (GO:0070189)	2.78553762
87	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.78287758
88	primary amino compound metabolic process (GO:1901160)	2.76420953
89	glomerular epithelial cell development (GO:0072310)	2.75678215
90	indole-containing compound metabolic process (GO:0042430)	2.74825601
91	snRNA transcription (GO:0009301)	2.74105568
92	intraciliary transport (GO:0042073)	2.73962378
93	double-strand break repair via homologous recombination (GO:0000724)	2.73771305
94	glomerular visceral epithelial cell development (GO:0072015)	2.73631336
95	recombinational repair (GO:0000725)	2.72617895
96	meiosis I (GO:0007127)	2.71229847
97	inositol phosphate dephosphorylation (GO:0046855)	2.69826623
98	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.69826623
99	serotonin metabolic process (GO:0042428)	2.69584384
100	gene silencing by RNA (GO:0031047)	2.67375637

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.63923119
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.29895863
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.02252030
4	FUS_26573619_Chip-Seq_HEK293_Human	2.80335999
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76846116
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71456028
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61041148
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42776524
9	ER_23166858_ChIP-Seq_MCF-7_Human	2.26056133
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.17850291
11	P300_19829295_ChIP-Seq_ESCs_Human	2.10367874
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06604033
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.04526970
14	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.03107673
15	CBP_20019798_ChIP-Seq_JUKART_Human	2.03107673
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00438591
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.94153413
18	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.93573892
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92503203
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88943292
21	STAT3_23295773_ChIP-Seq_U87_Human	1.85960349
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85446817
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.84589397
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.78445358
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78243591
26	EWS_26573619_Chip-Seq_HEK293_Human	1.73980956
27	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.70104279
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66820826
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66820826
30	TCF4_23295773_ChIP-Seq_U87_Human	1.61165756
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59760540
32	NANOG_19829295_ChIP-Seq_ESCs_Human	1.51635114
33	SOX2_19829295_ChIP-Seq_ESCs_Human	1.51635114
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51613735
35	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.51371427
36	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.50648087
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49419952
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.49103264
39	AR_25329375_ChIP-Seq_VCAP_Human	1.48296287
40	CDX2_22108803_ChIP-Seq_LS180_Human	1.48104906
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47702161
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47221371
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46643155
44	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.46057884
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.43271069
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39496643
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.38336940
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.35759398
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34386295
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34386295
51	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30969512
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29327506
53	AR_20517297_ChIP-Seq_VCAP_Human	1.28809055
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28343073
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.27200965
56	NCOR_22424771_ChIP-Seq_293T_Human	1.25682465
57	TP53_18474530_ChIP-ChIP_U2OS_Human	1.24989952
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24640696
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24460895
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23912589
61	PHF8_20622853_ChIP-Seq_HELA_Human	1.22449987
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21767927
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21388699
64	NFYB_21822215_ChIP-Seq_K562_Human	1.21227456
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.21077207
66	TBL1_22424771_ChIP-Seq_293T_Human	1.20574201
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20041479
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19794705
69	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18014591
70	ETV1_20927104_ChIP-Seq_GIST48_Human	1.15906055
71	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.14849785
72	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14849427
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14133605
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14037097
75	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.13220373
76	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.12951322
77	CJUN_26792858_Chip-Seq_BT549_Human	1.11573620
78	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10392431
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09673646
80	NFYA_21822215_ChIP-Seq_K562_Human	1.09633088
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08842829
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.08166357
83	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.07675222
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07639423
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06185738
86	JUN_21703547_ChIP-Seq_K562_Human	1.05102202
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04878017
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04513110
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04328468
90	EZH2_22144423_ChIP-Seq_EOC_Human	1.03810783
91	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.03485078
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02855578
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.02302998
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02231025
95	MYC_19829295_ChIP-Seq_ESCs_Human	1.02070585
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01848776
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01802282
98	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01545210
99	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00935538
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99850504

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.85851904
2	MP0005171_absent_coat_pigmentation	4.19339881
3	MP0000372_irregular_coat_pigmentation	3.68634657
4	MP0000569_abnormal_digit_pigmentation	3.27453368
5	MP0000015_abnormal_ear_pigmentation	3.09490524
6	MP0003136_yellow_coat_color	3.01718247
7	MP0003718_maternal_effect	2.74503537
8	MP0003646_muscle_fatigue	2.55218018
9	MP0003698_abnormal_male_reproductive	2.32857486
10	MP0008877_abnormal_DNA_methylation	2.31491675
11	MP0005174_abnormal_tail_pigmentation	2.25511842
12	MP0001929_abnormal_gametogenesis	2.22881771
13	MP0002095_abnormal_skin_pigmentation	2.22626508
14	MP0009697_abnormal_copulation	2.21464042
15	MP0003950_abnormal_plasma_membrane	2.18222526
16	MP0003195_calcinosis	2.16186474
17	MP0002102_abnormal_ear_morphology	2.07283186
18	MP0005551_abnormal_eye_electrophysiolog	2.02751414
19	MP0005670_abnormal_white_adipose	2.02111289
20	MP0008058_abnormal_DNA_repair	1.83217500
21	MP0001501_abnormal_sleep_pattern	1.81853944
22	MP0005075_abnormal_melanosome_morpholog	1.73425792
23	MP0008057_abnormal_DNA_replication	1.71585273
24	MP0005253_abnormal_eye_physiology	1.70026767
25	MP0008875_abnormal_xenobiotic_pharmacok	1.66507637
26	MP0005085_abnormal_gallbladder_physiolo	1.50537242
27	MP0003878_abnormal_ear_physiology	1.49798801
28	MP0005377_hearing/vestibular/ear_phenot	1.49798801
29	MP0002837_dystrophic_cardiac_calcinosis	1.49002621
30	MP0005408_hypopigmentation	1.45810077
31	MP0009046_muscle_twitch	1.45303735
32	MP0002138_abnormal_hepatobiliary_system	1.45130729
33	MP0000427_abnormal_hair_cycle	1.39609345
34	MP0001968_abnormal_touch/_nociception	1.38842241
35	MP0005084_abnormal_gallbladder_morpholo	1.38241196
36	MP0002653_abnormal_ependyma_morphology	1.35903741
37	MP0002210_abnormal_sex_determination	1.31855315
38	MP0010094_abnormal_chromosome_stability	1.31750883
39	MP0001764_abnormal_homeostasis	1.31334244
40	MP0003252_abnormal_bile_duct	1.27385724
41	MP0006276_abnormal_autonomic_nervous	1.26969869
42	MP0002234_abnormal_pharynx_morphology	1.26662132
43	MP0005395_other_phenotype	1.26617789
44	MP0006072_abnormal_retinal_apoptosis	1.23991240
45	MP0001545_abnormal_hematopoietic_system	1.23984990
46	MP0005397_hematopoietic_system_phenotyp	1.23984990
47	MP0006036_abnormal_mitochondrial_physio	1.20996699
48	MP0005646_abnormal_pituitary_gland	1.19748020
49	MP0000371_diluted_coat_color	1.17301413
50	MP0008775_abnormal_heart_ventricle	1.17004468
51	MP0004043_abnormal_pH_regulation	1.16835775
52	MP0000653_abnormal_sex_gland	1.15621173
53	MP0002161_abnormal_fertility/fecundity	1.15264260
54	MP0002160_abnormal_reproductive_system	1.13403951
55	MP0002132_abnormal_respiratory_system	1.11824141
56	MP0001145_abnormal_male_reproductive	1.11598195
57	MP0002938_white_spotting	1.10266373
58	MP0002822_catalepsy	1.09498858
59	MP0005083_abnormal_biliary_tract	1.03822908
60	MP0000230_abnormal_systemic_arterial	1.03185616
61	MP0002928_abnormal_bile_duct	0.99020646
62	MP0008995_early_reproductive_senescence	0.98686630
63	MP0005464_abnormal_platelet_physiology	0.96593493
64	MP0008872_abnormal_physiological_respon	0.96171165
65	MP0005167_abnormal_blood-brain_barrier	0.94795290
66	MP0001324_abnormal_eye_pigmentation	0.92933121
67	MP0003786_premature_aging	0.92665304
68	MP0004147_increased_porphyrin_level	0.91625873
69	MP0001984_abnormal_olfaction	0.91470190
70	MP0001661_extended_life_span	0.91317278
71	MP0000383_abnormal_hair_follicle	0.91239578
72	MP0006035_abnormal_mitochondrial_morpho	0.90607441
73	MP0005645_abnormal_hypothalamus_physiol	0.90458599
74	MP0008789_abnormal_olfactory_epithelium	0.88416482
75	MP0002736_abnormal_nociception_after	0.87006863
76	MP0000358_abnormal_cell_content/	0.84871274
77	MP0002876_abnormal_thyroid_physiology	0.83846584
78	MP0005360_urolithiasis	0.81761988
79	MP0004381_abnormal_hair_follicle	0.78932718
80	MP0005266_abnormal_metabolism	0.77724572
81	MP0002075_abnormal_coat/hair_pigmentati	0.77537165
82	MP0003806_abnormal_nucleotide_metabolis	0.77032874
83	MP0002229_neurodegeneration	0.74537709
84	MP0004484_altered_response_of	0.74526958
85	MP0000681_abnormal_thyroid_gland	0.74320258
86	MP0005365_abnormal_bile_salt	0.73757206
87	MP0004085_abnormal_heartbeat	0.73125555
88	MP0001986_abnormal_taste_sensitivity	0.72721837
89	MP0001486_abnormal_startle_reflex	0.72635817
90	MP0000631_abnormal_neuroendocrine_gland	0.71531984
91	MP0010678_abnormal_skin_adnexa	0.71058130
92	MP0001664_abnormal_digestion	0.70265987
93	MP0002735_abnormal_chemical_nociception	0.68987011
94	MP0009745_abnormal_behavioral_response	0.67942549
95	MP0005647_abnormal_sex_gland	0.67288120
96	MP0005389_reproductive_system_phenotype	0.66711670
97	MP0010368_abnormal_lymphatic_system	0.65924572
98	MP0003879_abnormal_hair_cell	0.65244023
99	MP0005310_abnormal_salivary_gland	0.64793223
100	MP0002272_abnormal_nervous_system	0.63846875

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.07941494
2	Absent/shortened dynein arms (HP:0200106)	5.07941494
3	Chronic hepatic failure (HP:0100626)	4.47759801
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.42721083
5	Abnormal ciliary motility (HP:0012262)	4.37074087
6	Abnormal respiratory motile cilium physiology (HP:0012261)	4.27906840
7	Tubulointerstitial nephritis (HP:0001970)	4.15466619
8	Abnormal respiratory motile cilium morphology (HP:0005938)	4.07885515
9	Abnormal respiratory epithelium morphology (HP:0012253)	4.07885515
10	Pancreatic cysts (HP:0001737)	3.94366965
11	Type II lissencephaly (HP:0007260)	3.68087938
12	Cerebellar dysplasia (HP:0007033)	3.55769747
13	Pancreatic fibrosis (HP:0100732)	3.54022842
14	Attenuation of retinal blood vessels (HP:0007843)	3.46908155
15	Nephronophthisis (HP:0000090)	3.37997545
16	True hermaphroditism (HP:0010459)	3.30770051
17	Severe visual impairment (HP:0001141)	3.24589199
18	Rhinitis (HP:0012384)	3.22517400
19	Abnormality of the renal medulla (HP:0100957)	3.06245267
20	Medial flaring of the eyebrow (HP:0010747)	2.97407760
21	Bony spicule pigmentary retinopathy (HP:0007737)	2.91277065
22	Abnormality of the renal cortex (HP:0011035)	2.90379390
23	Molar tooth sign on MRI (HP:0002419)	2.85918931
24	Abnormality of midbrain morphology (HP:0002418)	2.85918931
25	Amelogenesis imperfecta (HP:0000705)	2.74022578
26	Congenital stationary night blindness (HP:0007642)	2.70188135
27	Abnormality of macular pigmentation (HP:0008002)	2.68869673
28	Congenital sensorineural hearing impairment (HP:0008527)	2.63052921
29	Cystic liver disease (HP:0006706)	2.57970928
30	Tubular atrophy (HP:0000092)	2.56750996
31	Tubulointerstitial abnormality (HP:0001969)	2.55205274
32	Gaze-evoked nystagmus (HP:0000640)	2.53323668
33	Chronic bronchitis (HP:0004469)	2.49105924
34	Male infertility (HP:0003251)	2.47979401
35	Congenital primary aphakia (HP:0007707)	2.47940602
36	Albinism (HP:0001022)	2.47335509
37	Infertility (HP:0000789)	2.45178009
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.42770830
39	Decreased central vision (HP:0007663)	2.42402843
40	Nephrogenic diabetes insipidus (HP:0009806)	2.40643413
41	Gait imbalance (HP:0002141)	2.37341772
42	Febrile seizures (HP:0002373)	2.35279408
43	Bronchiectasis (HP:0002110)	2.32387101
44	Occipital encephalocele (HP:0002085)	2.30266974
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28054405
46	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.26764862
47	Hypoplasia of the fovea (HP:0007750)	2.26764862
48	Chromsome breakage (HP:0040012)	2.25974127
49	Polydipsia (HP:0001959)	2.22443257
50	Abnormal drinking behavior (HP:0030082)	2.22443257
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16609138
52	Lissencephaly (HP:0001339)	2.15446489
53	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12352005
54	Sclerocornea (HP:0000647)	2.12166834
55	Central scotoma (HP:0000603)	2.08530773
56	Retinal dysplasia (HP:0007973)	2.08013666
57	Male pseudohermaphroditism (HP:0000037)	2.07958520
58	Abnormality of the fovea (HP:0000493)	2.07493403
59	Neonatal respiratory distress (HP:0002643)	2.04936583
60	Congenital hepatic fibrosis (HP:0002612)	2.01957201
61	Abnormal rod and cone electroretinograms (HP:0008323)	2.01354864
62	3-Methylglutaconic aciduria (HP:0003535)	2.01094506
63	Abnormality of dental color (HP:0011073)	2.00510449
64	Median cleft lip (HP:0000161)	1.99008356
65	Astigmatism (HP:0000483)	1.97242706
66	Progressive cerebellar ataxia (HP:0002073)	1.96170714
67	Polyuria (HP:0000103)	1.95088721
68	Photophobia (HP:0000613)	1.94296097
69	Genital tract atresia (HP:0001827)	1.92853881
70	Thyroid-stimulating hormone excess (HP:0002925)	1.92791844
71	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.90208995
72	Cone-rod dystrophy (HP:0000548)	1.90112853
73	Stage 5 chronic kidney disease (HP:0003774)	1.89955515
74	Postaxial foot polydactyly (HP:0001830)	1.86702581
75	Sloping forehead (HP:0000340)	1.82870912
76	Poor coordination (HP:0002370)	1.80731333
77	Hypothermia (HP:0002045)	1.79458953
78	Vaginal atresia (HP:0000148)	1.79272781
79	Cutaneous melanoma (HP:0012056)	1.78490368
80	Abolished electroretinogram (ERG) (HP:0000550)	1.77757570
81	Portal hypertension (HP:0001409)	1.77075761
82	Absent speech (HP:0001344)	1.76094390
83	Severe muscular hypotonia (HP:0006829)	1.75850876
84	Abnormality of the hepatic vasculature (HP:0006707)	1.75315294
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73363270
86	Hypoplasia of the uterus (HP:0000013)	1.73246641
87	Anencephaly (HP:0002323)	1.73159372
88	Acute hepatic failure (HP:0006554)	1.72992778
89	Abnormality of the ileum (HP:0001549)	1.72632159
90	Progressive inability to walk (HP:0002505)	1.72239946
91	Aplasia/Hypoplasia of the macula (HP:0008059)	1.71936118
92	Scotoma (HP:0000575)	1.71005333
93	Abnormal protein glycosylation (HP:0012346)	1.68609494
94	Abnormal glycosylation (HP:0012345)	1.68609494
95	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.68609494
96	Abnormal protein N-linked glycosylation (HP:0012347)	1.68609494
97	Abnormal auditory evoked potentials (HP:0006958)	1.68604630
98	Aganglionic megacolon (HP:0002251)	1.66508300
99	Retinitis pigmentosa (HP:0000510)	1.66318870
100	Abnormal spermatogenesis (HP:0008669)	1.62486295

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.29843457
2	PLK4	3.51034531
3	MST4	3.16965666
4	STK38L	3.03754245
5	LATS1	2.97068077
6	MAP4K2	2.94470383
7	INSRR	2.90328051
8	BMPR1B	2.79283116
9	TRIM28	2.56423262
10	EIF2AK3	2.42213431
11	ZAK	2.25683417
12	PLK2	2.21265168
13	STK39	2.13750005
14	ADRBK2	2.08297459
15	PINK1	1.96798484
16	EIF2AK1	1.95992805
17	WNK4	1.93660286
18	TNIK	1.83584868
19	OXSR1	1.80898427
20	BCR	1.76665704
21	STK38	1.74021714
22	PIK3CG	1.68340286
23	PTK2B	1.64884613
24	ACVR1B	1.62289869
25	TAOK3	1.57816458
26	NUAK1	1.47358657
27	TIE1	1.36317975
28	SIK3	1.32017023
29	ERBB3	1.31873905
30	MST1R	1.29729240
31	BRD4	1.29150578
32	MAP3K4	1.26357667
33	FLT3	1.26310383
34	TEC	1.24377067
35	STK3	1.23787803
36	GRK1	1.21390452
37	MARK3	1.05111361
38	MET	1.03291229
39	MKNK2	0.96162866
40	TLK1	0.95580690
41	ADRBK1	0.90696679
42	BRSK2	0.90336296
43	MYLK	0.90065995
44	MAP3K12	0.89593290
45	PBK	0.89108119
46	MKNK1	0.81956334
47	CCNB1	0.77650328
48	MAPK13	0.77061024
49	PRKCE	0.76361484
50	WNK3	0.69495264
51	NEK6	0.66824621
52	BCKDK	0.66731660
53	NME1	0.65268162
54	PRKD3	0.64802883
55	AKT3	0.64079305
56	PDK2	0.63149922
57	BMPR2	0.56334480
58	PRKAA2	0.54476916
59	MAP2K7	0.54443444
60	NEK2	0.53958356
61	PAK3	0.53409608
62	CSNK1A1L	0.52016572
63	DAPK1	0.45338877
64	FER	0.43531933
65	PLK1	0.43489930
66	CSF1R	0.42177784
67	CAMK2A	0.41590558
68	MAP2K1	0.39208250
69	MAP3K13	0.39152701
70	TGFBR1	0.38595073
71	CDK8	0.37277676
72	ATM	0.36281310
73	KSR1	0.35429091
74	ABL1	0.34791711
75	ATR	0.34550501
76	PRKCG	0.34043636
77	PDK1	0.33084387
78	VRK1	0.32857716
79	IKBKB	0.32019666
80	PRKCQ	0.30742623
81	WEE1	0.30177123
82	IGF1R	0.30137227
83	PLK3	0.28349323
84	CDK7	0.27843765
85	CDK9	0.27775017
86	ITK	0.27106252
87	PRKCI	0.26579798
88	CHEK2	0.26333202
89	CSNK1G3	0.25084527
90	PRKCB	0.23734443
91	PKN1	0.22877023
92	PIM2	0.22758379
93	KIT	0.22574906
94	TNK2	0.21245179
95	PRKAA1	0.21043705
96	DAPK2	0.19896456
97	PDPK1	0.19587512
98	PRKACA	0.19212744
99	MAPK15	0.18780160
100	WNK1	0.18740190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.19629732
2	Olfactory transduction_Homo sapiens_hsa04740	3.12937578
3	Butanoate metabolism_Homo sapiens_hsa00650	2.96033753
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64018055
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47995451
6	Phototransduction_Homo sapiens_hsa04744	2.47722117
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.44697428
8	Basal transcription factors_Homo sapiens_hsa03022	2.42612934
9	Homologous recombination_Homo sapiens_hsa03440	2.28521675
10	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.28143544
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.03848064
12	Propanoate metabolism_Homo sapiens_hsa00640	1.95067816
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.89642334
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.87053983
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.85352609
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.79148273
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.73339806
18	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.65269933
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.56930053
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.54388124
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.53112016
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52247688
23	ABC transporters_Homo sapiens_hsa02010	1.47972030
24	Sphingolipid metabolism_Homo sapiens_hsa00600	1.46346014
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.45530658
26	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.44826115
27	Fatty acid degradation_Homo sapiens_hsa00071	1.44549740
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.42651279
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.40679832
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40176783
31	One carbon pool by folate_Homo sapiens_hsa00670	1.35184325
32	Nicotine addiction_Homo sapiens_hsa05033	1.31975341
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.31207101
34	Morphine addiction_Homo sapiens_hsa05032	1.30338619
35	Taste transduction_Homo sapiens_hsa04742	1.29401560
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.23485197
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18346677
38	Retinol metabolism_Homo sapiens_hsa00830	1.16317467
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15148707
40	Purine metabolism_Homo sapiens_hsa00230	1.13225222
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.11829386
42	RNA polymerase_Homo sapiens_hsa03020	1.09648465
43	Peroxisome_Homo sapiens_hsa04146	1.07678517
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.07086914
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04019720
46	Glutathione metabolism_Homo sapiens_hsa00480	0.97381829
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95920237
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95919684
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94231472
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93532029
51	Serotonergic synapse_Homo sapiens_hsa04726	0.91798313
52	GABAergic synapse_Homo sapiens_hsa04727	0.90107307
53	RNA degradation_Homo sapiens_hsa03018	0.88980783
54	Caffeine metabolism_Homo sapiens_hsa00232	0.86992054
55	RNA transport_Homo sapiens_hsa03013	0.86178299
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.85785103
57	Mismatch repair_Homo sapiens_hsa03430	0.85593652
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81097823
59	Base excision repair_Homo sapiens_hsa03410	0.81059186
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80211677
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.79703783
62	Tyrosine metabolism_Homo sapiens_hsa00350	0.79492857
63	Sulfur metabolism_Homo sapiens_hsa00920	0.78688423
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77918486
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.75442447
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73246841
67	Regulation of autophagy_Homo sapiens_hsa04140	0.72647618
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70086334
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70016694
70	Metabolic pathways_Homo sapiens_hsa01100	0.69750401
71	Salivary secretion_Homo sapiens_hsa04970	0.68496726
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66019393
73	Oocyte meiosis_Homo sapiens_hsa04114	0.65391430
74	Glutamatergic synapse_Homo sapiens_hsa04724	0.65329444
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65089527
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.65000453
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64993836
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61932047
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61887638
80	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.60618673
81	Huntingtons disease_Homo sapiens_hsa05016	0.60132391
82	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56888626
83	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.56433874
84	p53 signaling pathway_Homo sapiens_hsa04115	0.54876245
85	Circadian entrainment_Homo sapiens_hsa04713	0.50270060
86	Platelet activation_Homo sapiens_hsa04611	0.49386940
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49024444
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47764428
89	Asthma_Homo sapiens_hsa05310	0.47748226
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46925332
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43930051
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.41323982
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.41089828
94	Proteasome_Homo sapiens_hsa03050	0.40668697
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38245958
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36636692
97	Histidine metabolism_Homo sapiens_hsa00340	0.35513446
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34197931
99	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.33926204
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33779066

CCNYL2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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