CCPG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.45490601
2COPI coating of Golgi vesicle (GO:0048205)5.45490601
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.28143840
4regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.16837501
5protein retention in ER lumen (GO:0006621)4.05778244
6detection of molecule of bacterial origin (GO:0032490)3.87768787
7exocrine pancreas development (GO:0031017)3.78757141
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.67612158
9negative regulation of complement activation (GO:0045916)3.60607450
10COPII vesicle coating (GO:0048208)3.49235422
11peptide hormone processing (GO:0016486)3.47113225
12endocrine pancreas development (GO:0031018)3.38216484
13iron ion import (GO:0097286)3.29678759
14protein maturation by protein folding (GO:0022417)3.28712391
15negative regulation of protein activation cascade (GO:2000258)3.24183683
16microglial cell activation (GO:0001774)3.20925408
17activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.20300350
18macroautophagy (GO:0016236)3.18518495
19negative regulation of humoral immune response (GO:0002921)3.15314990
20ER overload response (GO:0006983)3.13616270
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09051921
22regulation of memory T cell differentiation (GO:0043380)3.07931407
23protein targeting to Golgi (GO:0000042)3.05209510
24cellular extravasation (GO:0045123)3.03886059
25sequestering of metal ion (GO:0051238)3.02888916
26import into cell (GO:0098657)3.01937011
27ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.01773284
28regulation of platelet aggregation (GO:0090330)2.99572239
29detection of calcium ion (GO:0005513)2.97513854
30leukocyte migration involved in inflammatory response (GO:0002523)2.96694498
31positive regulation of nuclease activity (GO:0032075)2.92753775
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91592194
33toxin metabolic process (GO:0009404)2.86920136
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86035093
35vesicle coating (GO:0006901)2.85506525
36neutrophil activation involved in immune response (GO:0002283)2.85063583
37relaxation of smooth muscle (GO:0044557)2.84874385
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84672650
39positive regulation by organism of defense response of other organism involved in symbiotic interact2.84672650
40modulation by symbiont of host immune response (GO:0052553)2.84672650
41positive regulation by symbiont of host defense response (GO:0052509)2.84672650
42modulation by symbiont of host defense response (GO:0052031)2.84672650
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84672650
44regulation of type B pancreatic cell apoptotic process (GO:2000674)2.84085393
45establishment of protein localization to Golgi (GO:0072600)2.78524964
46intra-Golgi vesicle-mediated transport (GO:0006891)2.77414139
47detection of external biotic stimulus (GO:0098581)2.76335281
48insulin secretion (GO:0030073)2.76104241
49signal peptide processing (GO:0006465)2.74527586
50regulation of beta-amyloid formation (GO:1902003)2.72564418
51protein localization to Golgi apparatus (GO:0034067)2.70091622
52positive regulation of insulin secretion (GO:0032024)2.68702655
53endoplasmic reticulum unfolded protein response (GO:0030968)2.66100810
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64237752
55regulation of amyloid precursor protein catabolic process (GO:1902991)2.62301215
56retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62187478
57cellular response to unfolded protein (GO:0034620)2.60066515
58negative regulation of cell killing (GO:0031342)2.59622897
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59622897
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.58486172
61L-phenylalanine catabolic process (GO:0006559)2.58486172
62regulation of nuclease activity (GO:0032069)2.58465624
63macrophage activation (GO:0042116)2.58371571
64regulation of platelet activation (GO:0010543)2.56708756
65regulation of synaptic vesicle exocytosis (GO:2000300)2.55955493
66positive regulation of glycolytic process (GO:0045821)2.55775771
67ER-nucleus signaling pathway (GO:0006984)2.55673825
68regulation of insulin secretion (GO:0050796)2.54245604
69intestinal cholesterol absorption (GO:0030299)2.54102833
70interleukin-6-mediated signaling pathway (GO:0070102)2.49802904
71neutrophil mediated immunity (GO:0002446)2.48766979
72cellular response to topologically incorrect protein (GO:0035967)2.48551099
73type B pancreatic cell development (GO:0003323)2.48382494
74macrophage activation involved in immune response (GO:0002281)2.48363987
75transcytosis (GO:0045056)2.48189191
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.44698260
77glandular epithelial cell differentiation (GO:0002067)2.44298793
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42236737
79positive regulation of cellular amide metabolic process (GO:0034250)2.39699324
80response to endoplasmic reticulum stress (GO:0034976)2.38990323
81synaptic vesicle maturation (GO:0016188)2.36932035
82regulation of interferon-beta biosynthetic process (GO:0045357)2.36284924
83activation of protein kinase A activity (GO:0034199)2.34251777
84detection of other organism (GO:0098543)2.32859830
85valine metabolic process (GO:0006573)2.31812961
86regulation of peptide hormone secretion (GO:0090276)2.30860223
87positive regulation of exocytosis (GO:0045921)2.29788528
88regulation of peptide secretion (GO:0002791)2.29526399
89nitric oxide mediated signal transduction (GO:0007263)2.29512400
90positive regulation of peptide secretion (GO:0002793)2.28956426
91regulation of synaptic vesicle transport (GO:1902803)2.28590764
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.28558720
93positive regulation of peptide hormone secretion (GO:0090277)2.28493300
94negative regulation of homotypic cell-cell adhesion (GO:0034111)2.27918858
95positive regulation of toll-like receptor signaling pathway (GO:0034123)2.27564127
96neutrophil activation (GO:0042119)2.27516709
97production of molecular mediator involved in inflammatory response (GO:0002532)2.27156523
98cellular response to glucagon stimulus (GO:0071377)2.27010964
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.26106281
100erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.25499548
101L-phenylalanine metabolic process (GO:0006558)2.25499548
102detection of biotic stimulus (GO:0009595)2.25152691
103negative regulation of digestive system process (GO:0060457)2.23611981
104regulation of mast cell activation (GO:0033003)2.23168354
105regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.22345808
106negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.21944266
107chemosensory behavior (GO:0007635)2.21887825
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.20310483
109regulation of ARF protein signal transduction (GO:0032012)2.20301290
110keratan sulfate catabolic process (GO:0042340)2.19433510
111negative regulation of interleukin-17 production (GO:0032700)2.19396297
112glandular epithelial cell development (GO:0002068)2.19370097
113regulation of calcium ion-dependent exocytosis (GO:0017158)2.18597876
114positive regulation of T cell mediated cytotoxicity (GO:0001916)2.18230824
115positive regulation of receptor recycling (GO:0001921)2.17631060
116sequestering of extracellular ligand from receptor (GO:0035581)2.16551923
117protein N-linked glycosylation via asparagine (GO:0018279)2.16325034
118peptidyl-asparagine modification (GO:0018196)2.15991168
119ER to Golgi vesicle-mediated transport (GO:0006888)2.15840862
120response to dietary excess (GO:0002021)2.15078372
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.14466308
122growth hormone secretion (GO:0030252)2.14370085
123peptide secretion (GO:0002790)2.12889234
124potassium ion import (GO:0010107)2.12846373
125peptide hormone secretion (GO:0030072)2.12706941
126positive regulation of vesicle fusion (GO:0031340)2.12498945
127myeloid leukocyte mediated immunity (GO:0002444)2.12280806
128tricarboxylic acid metabolic process (GO:0072350)2.12189745
129digestion (GO:0007586)2.12084315
130positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.11851781
131negative regulation of platelet activation (GO:0010544)2.11640698
132positive regulation of mast cell activation (GO:0033005)2.11278865
133response to unfolded protein (GO:0006986)2.10662651
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.10565653
135response to host immune response (GO:0052572)2.10565653
136Golgi organization (GO:0007030)2.10329295
137regulation of macrophage cytokine production (GO:0010935)2.09973808
138regulation of mast cell activation involved in immune response (GO:0033006)2.09940638
139magnesium ion transport (GO:0015693)2.09263260
140branched-chain amino acid metabolic process (GO:0009081)2.08910746
141membrane repolarization during action potential (GO:0086011)2.08140420
142synaptic vesicle exocytosis (GO:0016079)2.07385766
143superoxide anion generation (GO:0042554)2.07119033
144negative regulation of inclusion body assembly (GO:0090084)2.07030123
145negative regulation of glycoprotein biosynthetic process (GO:0010561)2.06927088
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.06560628
147peptidyl-tyrosine autophosphorylation (GO:0038083)2.06511165
148negative regulation of lymphocyte mediated immunity (GO:0002707)2.05711867
149regulation of mast cell degranulation (GO:0043304)2.05260769
150retinal metabolic process (GO:0042574)2.03658058
151response to topologically incorrect protein (GO:0035966)2.03596469
152negative regulation of protein autophosphorylation (GO:0031953)2.03273358
153regulation of T cell mediated cytotoxicity (GO:0001914)2.03122130
154endoplasmic reticulum organization (GO:0007029)2.02902216
155negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.02565313
156regulation of exocytosis (GO:0017157)2.01952452
157negative regulation of B cell mediated immunity (GO:0002713)2.01875155
158negative regulation of immunoglobulin mediated immune response (GO:0002890)2.01875155
159cGMP-mediated signaling (GO:0019934)2.01828598
160cellular response to ethanol (GO:0071361)2.01783721
161positive regulation of muscle hypertrophy (GO:0014742)2.01675023
162positive regulation of cardiac muscle hypertrophy (GO:0010613)2.01675023
163regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.01635092
164negative regulation of catecholamine secretion (GO:0033604)2.01158946
165regulation of integrin-mediated signaling pathway (GO:2001044)2.00946414
166regulation of hormone secretion (GO:0046883)2.00588338
167positive regulation of gamma-delta T cell activation (GO:0046645)2.00285248
168early endosome to late endosome transport (GO:0045022)2.00196104
169suckling behavior (GO:0001967)1.99752492
170response to pheromone (GO:0019236)1.99397768
171diterpenoid biosynthetic process (GO:0016102)1.99245466
172phagocytosis, recognition (GO:0006910)1.99129796
173protein N-linked glycosylation (GO:0006487)1.99101447
174positive regulation of macrophage differentiation (GO:0045651)1.98996591
175branched-chain amino acid catabolic process (GO:0009083)1.98532589
176succinate metabolic process (GO:0006105)1.98275132
177response to host (GO:0075136)1.98060221
178response to host defenses (GO:0052200)1.98060221
179response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.98060221
180dendritic cell migration (GO:0036336)1.97194242
181negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.96839868
182hypotonic response (GO:0006971)1.95781112
183regulation of B cell receptor signaling pathway (GO:0050855)1.95262323
184negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)1.94624114
185granulocyte activation (GO:0036230)1.92939911
186pyrimidine-containing compound transmembrane transport (GO:0072531)1.92395537
187regulation of interleukin-8 secretion (GO:2000482)1.90732367
188regulation of lipoprotein metabolic process (GO:0050746)1.90103712
189L-fucose catabolic process (GO:0042355)1.90013519
190fucose catabolic process (GO:0019317)1.90013519
191L-fucose metabolic process (GO:0042354)1.90013519
192negative regulation of response to reactive oxygen species (GO:1901032)1.89764286
193relaxation of muscle (GO:0090075)1.89490157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89403700
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.59959480
3EZH2_22144423_ChIP-Seq_EOC_Human2.30351329
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21975692
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.18040493
6GATA1_22025678_ChIP-Seq_K562_Human2.05619814
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04982788
8GBX2_23144817_ChIP-Seq_PC3_Human2.02967520
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96259270
10ESR1_20079471_ChIP-ChIP_T-47D_Human1.84385801
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80076791
12DROSHA_22980978_ChIP-Seq_HELA_Human1.76746126
13REST_21632747_ChIP-Seq_MESCs_Mouse1.72666839
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71451932
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69511888
16LXR_22158963_ChIP-Seq_LIVER_Mouse1.69105536
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.67193962
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66723599
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62707551
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61826412
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56996406
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56647036
23CJUN_26792858_Chip-Seq_BT549_Human1.55210260
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54683080
25NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54156020
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.51585359
27TP53_16413492_ChIP-PET_HCT116_Human1.51322305
28ER_23166858_ChIP-Seq_MCF-7_Human1.48367005
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.47850158
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47463470
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46033909
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.44516740
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42454793
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39089888
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.38943066
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37966004
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.37827206
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34494921
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34460719
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33506001
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33448977
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32923821
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32126032
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31441744
45VDR_24787735_ChIP-Seq_THP-1_Human1.31220598
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29296433
47SMAD4_21799915_ChIP-Seq_A2780_Human1.28395174
48RUNX_20019798_ChIP-Seq_JUKART_Human1.28152810
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27723404
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26847110
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.26214590
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24069271
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.23961495
54ZNF274_21170338_ChIP-Seq_K562_Hela1.23778747
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23061214
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.23054346
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.21468745
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21207421
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17658696
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15812141
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.15224103
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14676920
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.14606319
64* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14267282
65STAT3_23295773_ChIP-Seq_U87_Human1.13710567
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.13299054
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13061997
68* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12928346
69SPI1_23127762_ChIP-Seq_K562_Human1.11638613
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10938523
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10353398
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10316284
73* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10250700
74* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10250700
75CDX2_22108803_ChIP-Seq_LS180_Human1.09271072
76* ESR2_21235772_ChIP-Seq_MCF-7_Human1.08416461
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08365526
78TP63_23658742_ChIP-Seq_EP156T_Human1.08031583
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.07496273
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06800736
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06628340
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05536208
83* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04525212
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04278841
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04083892
86AHR_22903824_ChIP-Seq_MCF-7_Human1.03625706
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03229737
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.03185302
89AR_21572438_ChIP-Seq_LNCaP_Human1.02763161
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.02758345
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02555981
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.01964284
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01514106
94TP53_18474530_ChIP-ChIP_U2OS_Human1.01513711
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.00829671
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00508288
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00385278
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00232715
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.99851065
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.98612875
101RNF2_27304074_Chip-Seq_ESCs_Mouse0.98552997
102BRD4_25478319_ChIP-Seq_HGPS_Human0.95756161
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95581215
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95556148
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95065140
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95029507
107MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94857378
108CBP_20019798_ChIP-Seq_JUKART_Human0.94661426
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94661426
110AR_25329375_ChIP-Seq_VCAP_Human0.94566809
111P53_22387025_ChIP-Seq_ESCs_Mouse0.93930211
112* GATA2_19941826_ChIP-Seq_K562_Human0.93479847
113BCAT_22108803_ChIP-Seq_LS180_Human0.93365496
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93305489
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93305489
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93271248
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93265482
118* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92957127
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.92587019
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92387168
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.91523194
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91155238
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91070165
124TAF15_26573619_Chip-Seq_HEK293_Human0.90711429
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89571670
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.89497672
127* AR_19668381_ChIP-Seq_PC3_Human0.88901177
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88134164
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88064153
130GATA1_19941826_ChIP-Seq_K562_Human0.88006102
131TCF4_23295773_ChIP-Seq_U87_Human0.87106209
132FOXA1_25552417_ChIP-Seq_VCAP_Human0.86547468
133EED_16625203_ChIP-ChIP_MESCs_Mouse0.86463733
134* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85243731
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84401599
136FLI1_21867929_ChIP-Seq_TH2_Mouse0.82728254
137* GATA2_21666600_ChIP-Seq_HMVEC_Human0.82165908
138IGF1R_20145208_ChIP-Seq_DFB_Human0.81949265
139P300_19829295_ChIP-Seq_ESCs_Human0.81716650
140* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81540496
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.80294748
142CLOCK_20551151_ChIP-Seq_293T_Human0.80020370
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79985131
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79115558
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78055171
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.77141078
147DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77001022
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.75568979
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.75568979
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75115447
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.74901489
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74817894
153FOXH1_21741376_ChIP-Seq_ESCs_Human0.74715284
154HTT_18923047_ChIP-ChIP_STHdh_Human0.74676932
155VDR_22108803_ChIP-Seq_LS180_Human0.74481034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.15930997
2MP0002837_dystrophic_cardiac_calcinosis3.74204420
3MP0002909_abnormal_adrenal_gland3.49193173
4MP0000569_abnormal_digit_pigmentation3.41370464
5MP0004043_abnormal_pH_regulation3.22611469
6MP0009780_abnormal_chondrocyte_physiolo3.05620827
7MP0003183_abnormal_peptide_metabolism3.02702766
8MP0000013_abnormal_adipose_tissue2.98927788
9MP0003195_calcinosis2.67909945
10MP0005365_abnormal_bile_salt2.66752238
11MP0002693_abnormal_pancreas_physiology2.54685911
12MP0010386_abnormal_urinary_bladder2.54278777
13MP0008438_abnormal_cutaneous_collagen2.49099405
14MP0003828_pulmonary_edema2.41485588
15MP0001944_abnormal_pancreas_morphology2.31262302
16MP0008004_abnormal_stomach_pH2.30923462
17MP0004084_abnormal_cardiac_muscle2.27498405
18MP0005464_abnormal_platelet_physiology2.23116703
19MP0004270_analgesia2.07585269
20MP0001666_abnormal_nutrient_absorption2.07528095
21MP0005379_endocrine/exocrine_gland_phen2.04745741
22MP0005058_abnormal_lysosome_morphology2.03382845
23MP0005164_abnormal_response_to1.98066036
24MP0005220_abnormal_exocrine_pancreas1.97706738
25MP0004484_altered_response_of1.96391109
26MP0001958_emphysema1.92162652
27MP0005646_abnormal_pituitary_gland1.91536373
28MP0002877_abnormal_melanocyte_morpholog1.90356448
29MP0002078_abnormal_glucose_homeostasis1.87406114
30MP0001765_abnormal_ion_homeostasis1.86656123
31MP0004883_abnormal_blood_vessel1.80687814
32MP0002132_abnormal_respiratory_system1.78692172
33MP0003329_amyloid_beta_deposits1.77051103
34MP0003172_abnormal_lysosome_physiology1.76030793
35MP0003283_abnormal_digestive_organ1.72042340
36MP0000343_altered_response_to1.70867690
37MP0003303_peritoneal_inflammation1.70813897
38MP0004859_abnormal_synaptic_plasticity1.68920710
39MP0005083_abnormal_biliary_tract1.65109976
40MP0002419_abnormal_innate_immunity1.64285302
41MP0002139_abnormal_hepatobiliary_system1.62592484
42MP0005645_abnormal_hypothalamus_physiol1.61612205
43MP0003868_abnormal_feces_composition1.61015715
44MP0005085_abnormal_gallbladder_physiolo1.58151987
45MP0000003_abnormal_adipose_tissue1.55327114
46MP0003191_abnormal_cellular_cholesterol1.53079078
47MP0003252_abnormal_bile_duct1.51262617
48MP0001835_abnormal_antigen_presentation1.51182390
49MP0006054_spinal_hemorrhage1.49521192
50MP0009785_altered_susceptibility_to1.48630309
51MP0005535_abnormal_body_temperature1.48584078
52MP0003635_abnormal_synaptic_transmissio1.48254308
53MP0003656_abnormal_erythrocyte_physiolo1.45106018
54MP0010368_abnormal_lymphatic_system1.40401265
55MP0000465_gastrointestinal_hemorrhage1.40115681
56MP0005174_abnormal_tail_pigmentation1.39600694
57MP0008961_abnormal_basal_metabolism1.39391121
58MP0003300_gastrointestinal_ulcer1.39322739
59MP0005503_abnormal_tendon_morphology1.38404775
60MP0005275_abnormal_skin_tensile1.38347122
61MP0004130_abnormal_muscle_cell1.38253491
62MP0002734_abnormal_mechanical_nocicepti1.36960119
63MP0001533_abnormal_skeleton_physiology1.36002034
64MP0008875_abnormal_xenobiotic_pharmacok1.35741782
65MP0009643_abnormal_urine_homeostasis1.30968547
66MP0004264_abnormal_extraembryonic_tissu1.30443330
67MP0002876_abnormal_thyroid_physiology1.29796907
68MP0002295_abnormal_pulmonary_circulatio1.29504410
69MP0002118_abnormal_lipid_homeostasis1.29070776
70MP0005670_abnormal_white_adipose1.28059474
71MP0005332_abnormal_amino_acid1.27521327
72MP0003436_decreased_susceptibility_to1.27275721
73MP0003953_abnormal_hormone_level1.26200065
74MP0006072_abnormal_retinal_apoptosis1.26015934
75MP0003633_abnormal_nervous_system1.24783111
76MP0001879_abnormal_lymphatic_vessel1.24270148
77MP0002733_abnormal_thermal_nociception1.24140506
78MP0003806_abnormal_nucleotide_metabolis1.21894534
79MP0002064_seizures1.20939952
80MP0000685_abnormal_immune_system1.19735513
81MP0004145_abnormal_muscle_electrophysio1.19498401
82MP0006082_CNS_inflammation1.19080891
83MP0004036_abnormal_muscle_relaxation1.18794875
84MP0001970_abnormal_pain_threshold1.18390089
85MP0000678_abnormal_parathyroid_gland1.18239324
86MP0001756_abnormal_urination1.17974437
87MP0003075_altered_response_to1.16449665
88MP0002998_abnormal_bone_remodeling1.16225902
89MP0002272_abnormal_nervous_system1.15552489
90MP0008775_abnormal_heart_ventricle1.15419947
91MP0004272_abnormal_basement_membrane1.14741097
92MP0005636_abnormal_mineral_homeostasis1.13164487
93MP0000230_abnormal_systemic_arterial1.08623689
94MP0003279_aneurysm1.08189567
95MP0009745_abnormal_behavioral_response1.08065812
96MP0002063_abnormal_learning/memory/cond1.07026090
97MP0002822_catalepsy1.06696946
98MP0005388_respiratory_system_phenotype1.06309279
99MP0002133_abnormal_respiratory_system1.06309279
100MP0002896_abnormal_bone_mineralization1.05579175
101MP0002638_abnormal_pupillary_reflex1.05204335
102MP0004215_abnormal_myocardial_fiber1.04668245
103MP0005025_abnormal_response_to1.03787239
104MP0003045_fibrosis1.03600953
105MP0010329_abnormal_lipoprotein_level1.03562641
106MP0001502_abnormal_circadian_rhythm1.02830915
107MP0005167_abnormal_blood-brain_barrier1.02729479
108MP0002148_abnormal_hypersensitivity_rea1.02724770
109MP0002572_abnormal_emotion/affect_behav1.02075535
110MP0002735_abnormal_chemical_nociception1.01797787
111MP0005387_immune_system_phenotype1.01743276
112MP0001790_abnormal_immune_system1.01743276
113MP0001986_abnormal_taste_sensitivity1.01685150
114MP0003959_abnormal_lean_body1.00765351
115MP0001984_abnormal_olfaction1.00583161
116MP0003690_abnormal_glial_cell0.99792886
117MP0009840_abnormal_foam_cell0.99743045
118MP0005448_abnormal_energy_balance0.99354343
119MP0005310_abnormal_salivary_gland0.99064041
120MP0000604_amyloidosis0.99015098
121MP0005375_adipose_tissue_phenotype0.98575112
122MP0002928_abnormal_bile_duct0.98225895
123MP0001845_abnormal_inflammatory_respons0.96937842
124MP0001661_extended_life_span0.95943634
125MP0005165_increased_susceptibility_to0.95451859
126MP0005595_abnormal_vascular_smooth0.95293471
127MP0002168_other_aberrant_phenotype0.95010427
128MP0004885_abnormal_endolymph0.93810203
129MP0000749_muscle_degeneration0.93749247
130MP0006276_abnormal_autonomic_nervous0.93626798
131MP0002138_abnormal_hepatobiliary_system0.93028807
132MP0009764_decreased_sensitivity_to0.92993783
133MP0005166_decreased_susceptibility_to0.92515937
134MP0000920_abnormal_myelination0.92177669
135MP0000639_abnormal_adrenal_gland0.92128535
136MP0003879_abnormal_hair_cell0.91953792
137MP0002229_neurodegeneration0.91926432
138MP0004019_abnormal_vitamin_homeostasis0.91819630
139MP0000747_muscle_weakness0.91666036
140MP0008569_lethality_at_weaning0.91386847
141MP0003122_maternal_imprinting0.91005002
142MP0002234_abnormal_pharynx_morphology0.89785920
143MP0000015_abnormal_ear_pigmentation0.89776627
144MP0001968_abnormal_touch/_nociception0.89114509
145MP0000249_abnormal_blood_vessel0.89057984
146MP0001664_abnormal_digestion0.88700115
147MP0001501_abnormal_sleep_pattern0.87919613
148MP0002723_abnormal_immune_serum0.87656717
149MP0005000_abnormal_immune_tolerance0.87483571
150MP0002332_abnormal_exercise_endurance0.86344087
151MP0008874_decreased_physiological_sensi0.85468357
152MP0001542_abnormal_bone_strength0.85124440
153MP0005376_homeostasis/metabolism_phenot0.84280507
154MP0005410_abnormal_fertilization0.83718671
155MP0005084_abnormal_gallbladder_morpholo0.83298381
156MP0002452_abnormal_antigen_presenting0.82410691
157MP0003632_abnormal_nervous_system0.82285495
158MP0002069_abnormal_eating/drinking_beha0.80867341
159MP0005334_abnormal_fat_pad0.80578309
160MP0002067_abnormal_sensory_capabilities0.79957130
161MP0002277_abnormal_respiratory_mucosa0.79899519
162MP0004085_abnormal_heartbeat0.79601066
163MP0001800_abnormal_humoral_immune0.78204867
164MP0005360_urolithiasis0.77992937
165MP0003634_abnormal_glial_cell0.77299777
166MP0001851_eye_inflammation0.75952954
167MP0003631_nervous_system_phenotype0.75480547
168MP0003091_abnormal_cell_migration0.75034156
169MP0005620_abnormal_muscle_contractility0.74086318
170MP0000427_abnormal_hair_cycle0.73988549

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.99177435
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.66490723
3Hypoglycemic seizures (HP:0002173)4.61732306
4Hypoglycemic coma (HP:0001325)4.27132406
5Ketoacidosis (HP:0001993)4.19506050
6Symptomatic seizures (HP:0011145)4.07552372
7Gout (HP:0001997)3.69277213
8Insulin-resistant diabetes mellitus (HP:0000831)3.57679355
9Dysostosis multiplex (HP:0000943)3.57477957
10Hyperglycemia (HP:0003074)3.48748689
11Mitral stenosis (HP:0001718)3.39243970
12Prolonged bleeding time (HP:0003010)3.38495957
13Visual hallucinations (HP:0002367)3.30313182
14Ketosis (HP:0001946)3.26586478
15Decreased circulating renin level (HP:0003351)3.24747781
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.20958431
17Absent/shortened dynein arms (HP:0200106)3.20958431
18Gingival bleeding (HP:0000225)3.19235108
19Peritonitis (HP:0002586)3.17544941
20Orchitis (HP:0100796)3.15125413
21Agitation (HP:0000713)3.12807951
22Spontaneous hematomas (HP:0007420)3.11140422
23Optic neuritis (HP:0100653)3.09256386
24Retrobulbar optic neuritis (HP:0100654)3.09256386
25Urinary glycosaminoglycan excretion (HP:0003541)3.06516879
26Mucopolysacchariduria (HP:0008155)3.06516879
27Hyperactive renin-angiotensin system (HP:0000841)3.06448760
28Abnormality of calcium-phosphate metabolism (HP:0100530)3.02993830
29Abnormal ciliary motility (HP:0012262)3.01433226
30Myositis (HP:0100614)2.99160410
31Aortic aneurysm (HP:0004942)2.98603756
32Increased circulating renin level (HP:0000848)2.95751165
33Abnormality of endocrine pancreas physiology (HP:0012093)2.95742925
34Abnormality of the pancreatic islet cells (HP:0006476)2.95742925
35Hyporeflexia of lower limbs (HP:0002600)2.95485620
36Abnormality of polysaccharide metabolism (HP:0011012)2.94563286
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94563286
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94563286
39Abnormality of renin-angiotensin system (HP:0000847)2.91041429
40Late onset (HP:0003584)2.86591183
41Eczematoid dermatitis (HP:0000976)2.86142715
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85752620
43Large for gestational age (HP:0001520)2.84822684
44Hyperkalemia (HP:0002153)2.81694629
45Stomatitis (HP:0010280)2.79659746
46Hypokalemia (HP:0002900)2.78882550
47Recurrent gram-negative bacterial infections (HP:0005420)2.76978896
48Recurrent abscess formation (HP:0002722)2.73864744
49Neurofibrillary tangles (HP:0002185)2.70924689
50Recurrent bacterial skin infections (HP:0005406)2.66894908
51Retinal atrophy (HP:0001105)2.63319010
52Abnormality of potassium homeostasis (HP:0011042)2.61802559
53Conjugated hyperbilirubinemia (HP:0002908)2.59641683
54Menorrhagia (HP:0000132)2.58891791
55Abnormality of macrophages (HP:0004311)2.57303225
56Epistaxis (HP:0000421)2.54182848
57Pancreatic islet-cell hyperplasia (HP:0004510)2.53967441
58Hypokalemic alkalosis (HP:0001949)2.53536522
59Abnormality of the intrinsic pathway (HP:0010989)2.51012408
60Generalized aminoaciduria (HP:0002909)2.48363725
61Vascular tortuosity (HP:0004948)2.43882968
62Hyperlipoproteinemia (HP:0010980)2.43203268
63Abnormal respiratory motile cilium physiology (HP:0012261)2.42750542
64Hematochezia (HP:0002573)2.42093503
65Papilledema (HP:0001085)2.42090536
66Pheochromocytoma (HP:0002666)2.41875775
67Abnormality of chloride homeostasis (HP:0011422)2.39233638
68Aortic dissection (HP:0002647)2.38473313
69Hypothermia (HP:0002045)2.37749464
70Vacuolated lymphocytes (HP:0001922)2.35203485
71Abnormal respiratory epithelium morphology (HP:0012253)2.34910576
72Abnormal respiratory motile cilium morphology (HP:0005938)2.34910576
73Episodic fever (HP:0001954)2.32574071
74Oligomenorrhea (HP:0000876)2.31528097
75Arterial tortuosity (HP:0005116)2.31041191
76Gastrointestinal infarctions (HP:0005244)2.28603262
77Cardiovascular calcification (HP:0011915)2.28113065
78Petechiae (HP:0000967)2.27518796
79Hyperaldosteronism (HP:0000859)2.25943680
80Abnormal platelet volume (HP:0011876)2.23129085
81Arterial thrombosis (HP:0004420)2.21971770
82Protuberant abdomen (HP:0001538)2.21311577
83Cerebral inclusion bodies (HP:0100314)2.21047600
84Facial diplegia (HP:0001349)2.20783414
85Supranuclear gaze palsy (HP:0000605)2.19485020
86Abnormality of purine metabolism (HP:0004352)2.17189724
87Polycythemia (HP:0001901)2.15971690
88Increased mean platelet volume (HP:0011877)2.15058718
89Generalized hypopigmentation of hair (HP:0011358)2.14361514
90Purpura (HP:0000979)2.13048048
91Striae distensae (HP:0001065)2.11533134
92Abnormality of the frontal sinuses (HP:0002687)2.11020824
93EEG with generalized epileptiform discharges (HP:0011198)2.09827697
94Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09165980
95Abnormality of the common coagulation pathway (HP:0010990)2.09121379
96Progressive neurologic deterioration (HP:0002344)2.08669058
97Metaphyseal dysplasia (HP:0100255)2.07968305
98Rhinitis (HP:0012384)2.07102893
99Muscle fiber splitting (HP:0003555)2.06946328
100Abnormal pancreas size (HP:0012094)2.06410838
101Epileptiform EEG discharges (HP:0011182)2.05476792
102Hypsarrhythmia (HP:0002521)2.04792425
103Polydipsia (HP:0001959)2.04572837
104Abnormal drinking behavior (HP:0030082)2.04572837
105Amyloidosis (HP:0011034)2.03758349
106Spondylolisthesis (HP:0003302)2.03393008
107Failure to thrive in infancy (HP:0001531)2.03050398
108Hypotension (HP:0002615)2.02924122
109Restlessness (HP:0000711)2.02680073
110Resting tremor (HP:0002322)2.01686869
111Neuroendocrine neoplasm (HP:0100634)2.00670346
112Arthropathy (HP:0003040)1.98230481
113Metabolic alkalosis (HP:0200114)1.98063904
114Protrusio acetabuli (HP:0003179)1.95574540
115Keratoconjunctivitis sicca (HP:0001097)1.95516005
116Pulmonary embolism (HP:0002204)1.93520460
117Hyperuricemia (HP:0002149)1.91895347
118Increased purine levels (HP:0004368)1.91895347
119Growth hormone excess (HP:0000845)1.91792604
120Syncope (HP:0001279)1.90481132
121Vascular calcification (HP:0004934)1.90454791
122Tachypnea (HP:0002789)1.89444812
123Cerebral hemorrhage (HP:0001342)1.88675520
124Adrenal overactivity (HP:0002717)1.88255936
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88089467
126Febrile seizures (HP:0002373)1.87558802
127Hemoptysis (HP:0002105)1.87311234
128Postural instability (HP:0002172)1.86869038
129Anxiety (HP:0000739)1.86400280
130Keratoconjunctivitis (HP:0001096)1.86226547
131Muscle fibrillation (HP:0010546)1.85610019
132Abnormality of liposaccharide metabolism (HP:0010968)1.85056254
133Abnormality of glycosphingolipid metabolism (HP:0004343)1.85056254
134Abnormality of glycolipid metabolism (HP:0010969)1.85056254
135Focal motor seizures (HP:0011153)1.84398667
136Dysautonomia (HP:0002459)1.84156476
137Clumsiness (HP:0002312)1.83055059
138Global brain atrophy (HP:0002283)1.82400775
139Fair hair (HP:0002286)1.80776383
140Hyperphosphatemia (HP:0002905)1.80261642
141Bruising susceptibility (HP:0000978)1.79707814
142Bundle branch block (HP:0011710)1.79268850
143Abnormality of renal excretion (HP:0011036)1.79059906
144Hyperglycinemia (HP:0002154)1.78435804
145Insulin resistance (HP:0000855)1.78305954
146Papillary thyroid carcinoma (HP:0002895)1.78300051
147Hyperglycinuria (HP:0003108)1.77966443
148Depression (HP:0000716)1.77354198
149Widely spaced teeth (HP:0000687)1.77047346
150Renal salt wasting (HP:0000127)1.76739245
151Hypomagnesemia (HP:0002917)1.75050269
152Abnormality of fatty-acid metabolism (HP:0004359)1.74467890
153Asymmetric septal hypertrophy (HP:0001670)1.74177330
154Choroideremia (HP:0001139)1.74031868
155Exocrine pancreatic insufficiency (HP:0001738)1.73824727
156Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73739067
157Menstrual irregularities (HP:0000858)1.73606520
158Alkalosis (HP:0001948)1.73574587
159Macroorchidism (HP:0000053)1.72826670
160Difficulty running (HP:0009046)1.72549956
161Abnormal urine output (HP:0012590)1.72472219
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71696117
163Increased CSF protein (HP:0002922)1.71633272
164Ventricular fibrillation (HP:0001663)1.70713894
165Exercise-induced myalgia (HP:0003738)1.69460699
166Chronic bronchitis (HP:0004469)1.69070793
167Frequent falls (HP:0002359)1.69019224
168Gaze-evoked nystagmus (HP:0000640)1.68478294
169Abdominal distention (HP:0003270)1.68310972
170Polyuria (HP:0000103)1.68287116
171Elevated erythrocyte sedimentation rate (HP:0003565)1.68120462
172Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67594390
173Degeneration of the lateral corticospinal tracts (HP:0002314)1.67594390
174Increased cerebral lipofuscin (HP:0011813)1.66506248
175Myoglobinuria (HP:0002913)1.65980402
176Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65788707
177Hyperparathyroidism (HP:0000843)1.65009606
178Pulmonary infiltrates (HP:0002113)1.64799161
179Inability to walk (HP:0002540)1.64719651
180Intrahepatic cholestasis (HP:0001406)1.63441155
181Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63224889
182Gingivitis (HP:0000230)1.62225464
183Decreased central vision (HP:0007663)1.58838695
184Hypophosphatemic rickets (HP:0004912)1.58498190
185Impaired platelet aggregation (HP:0003540)1.58395569
186Abnormal platelet function (HP:0011869)1.58395569
187Abnormality of the vasculature of the conjunctiva (HP:0008054)1.58359210
188Congenital sensorineural hearing impairment (HP:0008527)1.57719272
189Conjunctival telangiectasia (HP:0000524)1.57708602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.88425424
2MAPK153.31686621
3TAOK33.11893938
4WNK42.44956485
5NTRK32.36437877
6ERN12.29036777
7RIPK42.28207226
8BCKDK2.21583641
9PRKD32.21250512
10WNK32.13355757
11AKT32.01461897
12MYLK2.00378408
13MAP3K21.99921625
14FRK1.98021715
15NTRK11.87548307
16ACVR1B1.81810989
17BLK1.80373146
18TRPM71.79447100
19PIK3CG1.78894667
20PTK2B1.77822773
21CAMKK21.74229148
22HIPK21.62098019
23ADRBK21.48685429
24MAP3K131.46034870
25MAP3K11.45273758
26MARK31.43133607
27PRKCH1.40461841
28UHMK11.37671928
29TEC1.36763970
30BMPR1B1.34062959
31NEK91.33757444
32EPHB11.33499124
33SIK11.33202028
34MAP3K31.32628989
35CSK1.28526636
36IRAK11.26803675
37FES1.25797447
38PAK31.24295444
39FGFR41.24028130
40WNK11.23975492
41TYK21.23945165
42SGK2231.19078289
43SGK4941.19078289
44GRK61.16821025
45KSR11.16012729
46PINK11.15941177
47MAP2K41.15200188
48SIK31.10977155
49MAP3K91.10799545
50IRAK21.08503345
51BMPR21.08127707
52ADRBK11.03896505
53PHKG11.02756356
54PHKG21.02756356
55KSR21.02315707
56OXSR11.02180702
57PASK0.99644726
58OBSCN0.99278162
59STK380.99070266
60PTK20.98497917
61TRIB30.97618939
62MAP3K40.97300743
63FER0.96998974
64HCK0.95659548
65EPHA30.95347366
66YES10.94858573
67SGK30.94753286
68SGK20.93401867
69RET0.93155547
70PRKD20.92999276
71PLK20.90322885
72MAP3K120.89625594
73STK390.89111856
74MAP2K30.87263333
75KIT0.86706996
76SYK0.85295116
77GRK50.84393892
78BTK0.84116197
79CAMK1G0.83150092
80DAPK20.82832547
81DDR20.80361734
82PNCK0.79029415
83MAP2K70.78702424
84FGR0.78461339
85PRKCE0.78193103
86PAK60.78001928
87TRIM280.77970635
88PRKG20.76752421
89PDGFRA0.74020992
90ITK0.72719432
91MAPK120.72694622
92PDPK10.72608853
93JAK30.70827020
94CAMKK10.70675091
95PRKAA10.70482588
96PRKD10.70372664
97MUSK0.69793863
98CDK50.69708585
99RAF10.69570078
100CDC42BPA0.68732826
101JAK10.68471257
102PIK3CA0.67783128
103JAK20.66941984
104IRAK30.66566107
105PDK20.65642163
106STK110.64049522
107NEK60.63254841
108PTK60.62414756
109GRK10.61730371
110CAMK2D0.61324894
111MAP3K70.60852641
112LYN0.60838151
113LMTK20.60479808
114PDK40.59751915
115PDK30.59751915
116PRKCQ0.59728901
117PDK10.58616861
118FLT30.57421789
119MOS0.56333937
120MINK10.56110136
121CAMK2B0.54568144
122BCR0.51546500
123MARK20.50361399
124MAP3K140.50354480
125CAMK2A0.50301446
126MAPKAPK30.49249761
127TNK20.49202426
128TXK0.49190733
129FGFR20.48989197
130IRAK40.48771901
131PRKG10.48718434
132PRPF4B0.48209651
133CASK0.48117296
134PRKAA20.47534263
135DYRK1B0.47465538
136FGFR30.47195865
137STK30.46481394
138MAPK130.45993476
139TGFBR20.45906870
140PRKACG0.45745032
141NLK0.45740288
142MAP2K20.45695625
143MET0.44881181
144ROCK10.44797389
145SGK10.43203659
146PRKCG0.42014105
147PDGFRB0.41951090
148CAMK1D0.41047910
149GRK70.40192348
150PRKACA0.36692484
151DYRK1A0.36641682
152TIE10.36630600
153ZAP700.36502472

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.75686108
2Protein export_Homo sapiens_hsa030602.43355378
3Insulin secretion_Homo sapiens_hsa049112.39944763
4Sulfur metabolism_Homo sapiens_hsa009202.15009828
5Pancreatic secretion_Homo sapiens_hsa049721.88717954
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86960106
7Staphylococcus aureus infection_Homo sapiens_hsa051501.69294041
8Platelet activation_Homo sapiens_hsa046111.62064875
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60195077
10Type II diabetes mellitus_Homo sapiens_hsa049301.57435015
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52888231
12Lysosome_Homo sapiens_hsa041421.46355310
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45764115
14Carbohydrate digestion and absorption_Homo sapiens_hsa049731.42974632
15Butanoate metabolism_Homo sapiens_hsa006501.42107879
16Vibrio cholerae infection_Homo sapiens_hsa051101.41323747
17Phagosome_Homo sapiens_hsa041451.40783557
18Synaptic vesicle cycle_Homo sapiens_hsa047211.39258684
19Malaria_Homo sapiens_hsa051441.35083114
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27877214
21Complement and coagulation cascades_Homo sapiens_hsa046101.27692460
22Osteoclast differentiation_Homo sapiens_hsa043801.26476133
23GABAergic synapse_Homo sapiens_hsa047271.24782178
24Cocaine addiction_Homo sapiens_hsa050301.23123077
25Nitrogen metabolism_Homo sapiens_hsa009101.23064751
26Collecting duct acid secretion_Homo sapiens_hsa049661.20326535
27Leishmaniasis_Homo sapiens_hsa051401.19445239
28Other glycan degradation_Homo sapiens_hsa005111.17139007
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16405031
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13935085
31Tuberculosis_Homo sapiens_hsa051521.13684319
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13289946
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12699606
34Regulation of autophagy_Homo sapiens_hsa041401.12487007
35Taste transduction_Homo sapiens_hsa047421.10841401
36Amphetamine addiction_Homo sapiens_hsa050311.10311047
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08979945
38ECM-receptor interaction_Homo sapiens_hsa045121.08911424
39Fatty acid degradation_Homo sapiens_hsa000711.07326467
40Tryptophan metabolism_Homo sapiens_hsa003801.06713968
41Circadian entrainment_Homo sapiens_hsa047131.06385050
42Propanoate metabolism_Homo sapiens_hsa006401.03034987
43Arachidonic acid metabolism_Homo sapiens_hsa005901.02471356
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00237874
45Chemical carcinogenesis_Homo sapiens_hsa052040.99305006
46Morphine addiction_Homo sapiens_hsa050320.96953306
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95881248
48Thyroid hormone synthesis_Homo sapiens_hsa049180.93800536
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.92890975
50Protein digestion and absorption_Homo sapiens_hsa049740.92840510
51ABC transporters_Homo sapiens_hsa020100.90300070
52Starch and sucrose metabolism_Homo sapiens_hsa005000.89572700
53Fat digestion and absorption_Homo sapiens_hsa049750.89360923
54Dopaminergic synapse_Homo sapiens_hsa047280.88762587
55Salivary secretion_Homo sapiens_hsa049700.87377169
56Renin secretion_Homo sapiens_hsa049240.86863954
57Circadian rhythm_Homo sapiens_hsa047100.86665112
58Glucagon signaling pathway_Homo sapiens_hsa049220.86277151
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86031883
60Chemokine signaling pathway_Homo sapiens_hsa040620.85829039
61Gastric acid secretion_Homo sapiens_hsa049710.85786534
62Type I diabetes mellitus_Homo sapiens_hsa049400.83096651
63Long-term potentiation_Homo sapiens_hsa047200.83010866
64Fatty acid metabolism_Homo sapiens_hsa012120.82926521
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82786683
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82287758
67Insulin resistance_Homo sapiens_hsa049310.81810267
68Histidine metabolism_Homo sapiens_hsa003400.81726524
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81459437
70Cholinergic synapse_Homo sapiens_hsa047250.80877540
71Glycerolipid metabolism_Homo sapiens_hsa005610.80863290
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80442213
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.80150714
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79980814
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79585167
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.78989193
77Mineral absorption_Homo sapiens_hsa049780.78944238
78Olfactory transduction_Homo sapiens_hsa047400.78405877
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77701660
80N-Glycan biosynthesis_Homo sapiens_hsa005100.77321197
81Bile secretion_Homo sapiens_hsa049760.76897369
82Glutamatergic synapse_Homo sapiens_hsa047240.76328807
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76116315
84Hematopoietic cell lineage_Homo sapiens_hsa046400.75535037
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74853800
86Amoebiasis_Homo sapiens_hsa051460.74618995
87Focal adhesion_Homo sapiens_hsa045100.74449499
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73634584
89Pertussis_Homo sapiens_hsa051330.73595973
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73289018
91Nicotine addiction_Homo sapiens_hsa050330.72905031
92Fatty acid elongation_Homo sapiens_hsa000620.72579540
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72339143
94Estrogen signaling pathway_Homo sapiens_hsa049150.71925287
95Linoleic acid metabolism_Homo sapiens_hsa005910.71764880
96mTOR signaling pathway_Homo sapiens_hsa041500.71647912
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71646777
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71521872
99Prion diseases_Homo sapiens_hsa050200.71021780
100Gap junction_Homo sapiens_hsa045400.70879885
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70414779
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70267013
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68782198
104Toxoplasmosis_Homo sapiens_hsa051450.67766766
105Caffeine metabolism_Homo sapiens_hsa002320.66894653
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66523891
107Serotonergic synapse_Homo sapiens_hsa047260.65841248
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.65584043
109PPAR signaling pathway_Homo sapiens_hsa033200.64433480
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.63733115
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.63578072
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62633647
113cAMP signaling pathway_Homo sapiens_hsa040240.62456899
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61806332
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.61537786
116Rheumatoid arthritis_Homo sapiens_hsa053230.60734092
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60551303
118Sphingolipid metabolism_Homo sapiens_hsa006000.60502570
119African trypanosomiasis_Homo sapiens_hsa051430.60333543
120Dilated cardiomyopathy_Homo sapiens_hsa054140.60219804
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60198105
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59608283
123Retinol metabolism_Homo sapiens_hsa008300.59593661
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.59199096
125B cell receptor signaling pathway_Homo sapiens_hsa046620.58112829
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58046604
127Arginine biosynthesis_Homo sapiens_hsa002200.57658127
128FoxO signaling pathway_Homo sapiens_hsa040680.57371313
129Inositol phosphate metabolism_Homo sapiens_hsa005620.56442842
130Peroxisome_Homo sapiens_hsa041460.55640151
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55595508
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55593400
133Folate biosynthesis_Homo sapiens_hsa007900.55588473
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54529398
135Insulin signaling pathway_Homo sapiens_hsa049100.53858925
136Legionellosis_Homo sapiens_hsa051340.53171403
137Phenylalanine metabolism_Homo sapiens_hsa003600.52736458
138Ovarian steroidogenesis_Homo sapiens_hsa049130.51895098
139Calcium signaling pathway_Homo sapiens_hsa040200.51836113
140beta-Alanine metabolism_Homo sapiens_hsa004100.51539393
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50576074
142Pyruvate metabolism_Homo sapiens_hsa006200.47074203
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46164576
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46149520
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44355476
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43798862
147Selenocompound metabolism_Homo sapiens_hsa004500.43273269
148Oxytocin signaling pathway_Homo sapiens_hsa049210.41524182
149Long-term depression_Homo sapiens_hsa047300.41045661
150Dorso-ventral axis formation_Homo sapiens_hsa043200.39951322
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39664535
152Tyrosine metabolism_Homo sapiens_hsa003500.39545935
153AMPK signaling pathway_Homo sapiens_hsa041520.38905040
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38495152

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