CCR10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)6.34081247
2positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.38331054
3regulation of somitogenesis (GO:0014807)5.26029689
4regulation of B cell receptor signaling pathway (GO:0050855)4.92446623
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.79340007
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79340007
7regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.72160066
8B cell homeostasis (GO:0001782)4.62652957
9leukocyte aggregation (GO:0070486)4.62516747
10positive thymic T cell selection (GO:0045059)4.59109659
11heparin metabolic process (GO:0030202)4.55562176
12heparin biosynthetic process (GO:0030210)4.55562176
13negative regulation of cell killing (GO:0031342)4.52093502
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52093502
15complement activation, classical pathway (GO:0006958)4.38202966
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.38147049
17regulation of interferon-gamma biosynthetic process (GO:0045072)4.38121909
18antigen processing and presentation of endogenous antigen (GO:0019883)4.30164024
19signal peptide processing (GO:0006465)4.26950498
20negative thymic T cell selection (GO:0045060)4.09716519
21positive regulation of gamma-delta T cell activation (GO:0046645)4.06435334
22B cell proliferation (GO:0042100)3.99385965
23innate immune response in mucosa (GO:0002227)3.97374512
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.95059357
25regulation of protein heterodimerization activity (GO:0043497)3.92935881
26thymic T cell selection (GO:0045061)3.85696678
27negative T cell selection (GO:0043383)3.83765558
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80115985
29T-helper 1 type immune response (GO:0042088)3.75146956
30cellular response to zinc ion (GO:0071294)3.70940953
31negative regulation of calcium ion transport into cytosol (GO:0010523)3.66260728
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.63513523
33negative regulation of B cell proliferation (GO:0030889)3.62275754
34protein insertion into membrane (GO:0051205)3.61322893
35GDP-mannose metabolic process (GO:0019673)3.58013410
36regulation of isotype switching to IgG isotypes (GO:0048302)3.56746359
37cellular ketone body metabolic process (GO:0046950)3.56323732
38nucleosome assembly (GO:0006334)3.53644127
39regulation of B cell apoptotic process (GO:0002902)3.52409157
40complement activation (GO:0006956)3.51299910
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.48518217
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.45433880
43antibacterial humoral response (GO:0019731)3.44918684
44COPI coating of Golgi vesicle (GO:0048205)3.43693262
45Golgi transport vesicle coating (GO:0048200)3.43693262
46ribosomal small subunit biogenesis (GO:0042274)3.43048049
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42550114
48negative regulation of B cell apoptotic process (GO:0002903)3.40633727
49mitochondrial fusion (GO:0008053)3.28363868
50DNA deamination (GO:0045006)3.26944780
51mucosal immune response (GO:0002385)3.24052965
52positive T cell selection (GO:0043368)3.23421173
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20192176
54regulation of B cell proliferation (GO:0030888)3.18791284
55metallo-sulfur cluster assembly (GO:0031163)3.17287681
56iron-sulfur cluster assembly (GO:0016226)3.17287681
57mannose metabolic process (GO:0006013)3.16802090
58regulation of apoptotic process involved in morphogenesis (GO:1902337)3.16694841
59chromatin assembly (GO:0031497)3.16644476
60mitochondrion distribution (GO:0048311)3.15066063
61regulation of gamma-delta T cell differentiation (GO:0045586)3.11910990
62regulation of interferon-beta biosynthetic process (GO:0045357)3.10079407
63interferon-gamma-mediated signaling pathway (GO:0060333)3.10079291
64negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.08702910
65Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.07042840
66immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.07042840
67Fc-gamma receptor signaling pathway (GO:0038094)3.07042840
68regulation of translational fidelity (GO:0006450)3.06861249
69response to type I interferon (GO:0034340)3.06417009
70protein-DNA complex assembly (GO:0065004)3.05912469
71positive regulation of protein oligomerization (GO:0032461)3.05859219
72cytidine metabolic process (GO:0046087)3.05609634
73cytidine catabolic process (GO:0006216)3.05609634
74cytidine deamination (GO:0009972)3.05609634
75response to interleukin-15 (GO:0070672)3.05126396
76antimicrobial humoral response (GO:0019730)3.04261096
77heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.04009945
78T cell selection (GO:0045058)3.02870154
79regulation of translational termination (GO:0006449)3.02517145
80Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.02290683
81ketone body metabolic process (GO:1902224)3.01892514
82type I interferon signaling pathway (GO:0060337)3.01266093
83cellular response to type I interferon (GO:0071357)3.01266093
84immunoglobulin mediated immune response (GO:0016064)3.00535547
85nucleoside diphosphate catabolic process (GO:0009134)2.98873578
86regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.97745555
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96140174
88modulation by symbiont of host cellular process (GO:0044068)2.95997523
89organ or tissue specific immune response (GO:0002251)2.95312855
90glomerular visceral epithelial cell development (GO:0072015)2.95218827
91cellular response to virus (GO:0098586)2.94762460
92nucleosome organization (GO:0034728)2.92575471
93B cell receptor signaling pathway (GO:0050853)2.91834347
94regulation of response to interferon-gamma (GO:0060330)2.90910624
95regulation of alpha-beta T cell proliferation (GO:0046640)2.88810828
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87448221
97cellular response to nicotine (GO:0071316)2.86669318
98myeloid dendritic cell differentiation (GO:0043011)2.85506570
99T cell migration (GO:0072678)2.84822303
100regulation of gamma-delta T cell activation (GO:0046643)2.83432156
101cellular response to interferon-beta (GO:0035458)2.83282853
102respiratory burst (GO:0045730)2.83258560
103negative regulation of phagocytosis (GO:0050765)2.82234721
104activation of MAPKKK activity (GO:0000185)2.81610392
105protein-cofactor linkage (GO:0018065)2.81480846
106respiratory electron transport chain (GO:0022904)2.80860385
107potassium ion export (GO:0071435)2.79036248
108T cell lineage commitment (GO:0002360)2.78328985
109electron transport chain (GO:0022900)2.77062439
110regulation of mitochondrial translation (GO:0070129)2.74835735
111membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74420230
112immune response-activating cell surface receptor signaling pathway (GO:0002429)2.73877937
113regulation of translational elongation (GO:0006448)2.73310150
114positive regulation of catecholamine secretion (GO:0033605)2.73014997
115regulation of interferon-alpha production (GO:0032647)2.72738684
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.72370827
117lymphocyte costimulation (GO:0031294)2.70112641
118regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.69510864
119sodium ion export (GO:0071436)2.68828286
120tongue development (GO:0043586)2.68736610
121sequestering of metal ion (GO:0051238)2.67342589
122T cell costimulation (GO:0031295)2.67130188
123cellular response to interleukin-15 (GO:0071350)2.66319150
124ncRNA 3-end processing (GO:0043628)2.65990080
125urea cycle (GO:0000050)2.65900934
126urea metabolic process (GO:0019627)2.65900934
127positive regulation of histone deacetylation (GO:0031065)2.62809673
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62281641
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.62281641
130modulation by symbiont of host immune response (GO:0052553)2.62281641
131positive regulation by symbiont of host defense response (GO:0052509)2.62281641
132modulation by symbiont of host defense response (GO:0052031)2.62281641
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62281641
134positive regulation of p38MAPK cascade (GO:1900745)2.61830931
135cellular extravasation (GO:0045123)2.61105456
136antigen receptor-mediated signaling pathway (GO:0050851)2.61104901
137positive regulation of B cell proliferation (GO:0030890)2.60772086
138protein-DNA complex subunit organization (GO:0071824)2.60562954
139modulation by virus of host process (GO:0019054)2.59527750
140positive regulation of interferon-alpha production (GO:0032727)2.58486645
141neuron remodeling (GO:0016322)2.57660175
142ER overload response (GO:0006983)2.57058713
143pyrimidine ribonucleoside catabolic process (GO:0046133)2.55429212
144carnitine shuttle (GO:0006853)2.55411213
145lymphocyte homeostasis (GO:0002260)2.54924409
146peptidyl-arginine omega-N-methylation (GO:0035247)2.54656550
147mesenchymal cell differentiation involved in kidney development (GO:0072161)2.54361366
148mesenchymal cell differentiation involved in renal system development (GO:2001012)2.54361366
149low-density lipoprotein particle clearance (GO:0034383)2.53835270
150regulation of B cell differentiation (GO:0045577)2.52851359
151NIK/NF-kappaB signaling (GO:0038061)2.52683200
152phosphatidylglycerol biosynthetic process (GO:0006655)2.52115311
153sequestering of actin monomers (GO:0042989)2.50716891
154regulation of telomerase activity (GO:0051972)2.50387566
155T cell receptor signaling pathway (GO:0050852)2.49710933
156positive regulation of B cell differentiation (GO:0045579)2.48969549
157viral transcription (GO:0019083)2.48170996
158leukocyte cell-cell adhesion (GO:0007159)2.48099840
159negative regulation of cell cycle arrest (GO:0071157)2.47977063
160intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.47508468
161negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.45995854
162DNA replication checkpoint (GO:0000076)2.45800249
163negative regulation of bone remodeling (GO:0046851)2.44493126
164positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.44273197
165N-acetylneuraminate metabolic process (GO:0006054)2.44094307
166positive regulation of macrophage differentiation (GO:0045651)2.43388249
167glomerular epithelial cell development (GO:0072310)2.43271414
168Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41985178
169T cell homeostasis (GO:0043029)2.41900875
170nitrogen cycle metabolic process (GO:0071941)2.41801636
171regulation of type I interferon-mediated signaling pathway (GO:0060338)2.41042366
172negative regulation of type 2 immune response (GO:0002829)2.39861395
173regulation of sequestering of triglyceride (GO:0010889)2.39099063
174positive regulation of protein homooligomerization (GO:0032464)2.38986559
175activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38763128
176alkaloid metabolic process (GO:0009820)2.36833329
177apoptotic cell clearance (GO:0043277)2.36709255
178positive regulation of nuclease activity (GO:0032075)2.34513503
179melanin biosynthetic process (GO:0042438)2.34059851
180T cell apoptotic process (GO:0070231)2.33808691
181negative regulation of bone resorption (GO:0045779)2.33327881
182vascular endothelial growth factor signaling pathway (GO:0038084)2.33102259
183positive regulation of fatty acid beta-oxidation (GO:0032000)2.32827591
184melanin metabolic process (GO:0006582)2.32336700
185maternal placenta development (GO:0001893)2.31987259
186tyrosine metabolic process (GO:0006570)2.31680277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.20026432
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.03237118
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.82730384
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.59552407
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56842770
6E2F7_22180533_ChIP-Seq_HELA_Human3.52763379
7VDR_21846776_ChIP-Seq_THP-1_Human2.92875105
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84384988
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74364565
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66543918
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65886456
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63775127
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.51335514
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43085779
15MAF_26560356_Chip-Seq_TH1_Human2.38761726
16CIITA_25753668_ChIP-Seq_RAJI_Human2.35175764
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.34166401
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32600073
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26014290
20VDR_24763502_ChIP-Seq_THP-1_Human2.25475870
21MYC_22102868_ChIP-Seq_BL_Human2.19737494
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18716145
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17691045
24RUNX_20019798_ChIP-Seq_JUKART_Human2.15041443
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11573048
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10684935
27ZNF263_19887448_ChIP-Seq_K562_Human2.09456566
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07446292
29* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05679750
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04513719
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00329359
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99832919
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.99710288
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98533036
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98225981
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97022778
37UTX_26944678_Chip-Seq_JUKART_Human1.95214145
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.94858356
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93766853
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92756345
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91135467
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91070299
43* KDM2B_26808549_Chip-Seq_DND41_Human1.89901197
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89528391
45MYB_26560356_Chip-Seq_TH2_Human1.88250870
46* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88040185
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86971614
48* TCF7_22412390_ChIP-Seq_EML_Mouse1.86025848
49XRN2_22483619_ChIP-Seq_HELA_Human1.85106451
50* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83202382
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82478737
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82333956
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.81287418
54* LXR_22292898_ChIP-Seq_THP-1_Human1.80539558
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.80382723
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80350944
57SPI1_23127762_ChIP-Seq_K562_Human1.77401766
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75059872
59* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74102742
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.71051743
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68401093
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68057049
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66947428
64* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65782087
65* MYB_26560356_Chip-Seq_TH1_Human1.65094006
66CLOCK_20551151_ChIP-Seq_293T_Human1.64366042
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64196909
68VDR_23849224_ChIP-Seq_CD4+_Human1.59214131
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58900207
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57152369
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55844834
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.53922077
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.51738399
74BCL6_27268052_Chip-Seq_Bcells_Human1.50694297
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.50624922
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.43264256
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.41821476
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39037886
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.38094890
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37880602
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.36603846
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36371274
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36044444
84* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35046841
85BCOR_27268052_Chip-Seq_Bcells_Human1.33309877
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33129467
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32219638
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32015808
89GATA3_27048872_Chip-Seq_THYMUS_Human1.31450420
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30911206
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30641045
92* MAF_26560356_Chip-Seq_TH2_Human1.30568952
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29842699
94IRF1_19129219_ChIP-ChIP_H3396_Human1.29615580
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29584193
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29472034
97GATA1_22025678_ChIP-Seq_K562_Human1.29345182
98SCL_19346495_ChIP-Seq_HPC-7_Human1.28815929
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27831215
100MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27034540
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26355566
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.25637806
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25410290
104P68_20966046_ChIP-Seq_HELA_Human1.25035799
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24115105
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23623165
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.23228238
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22861164
109DCP1A_22483619_ChIP-Seq_HELA_Human1.22564977
110PU_27001747_Chip-Seq_BMDM_Mouse1.21102368
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20834733
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19323172
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18931034
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18928715
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18896506
116* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18118260
117ELF1_20517297_ChIP-Seq_JURKAT_Human1.16036355
118E2F1_20622854_ChIP-Seq_HELA_Human1.15598511
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15378497
120GABP_19822575_ChIP-Seq_HepG2_Human1.14818518
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.13846422
122TET1_21451524_ChIP-Seq_MESCs_Mouse1.13728725
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13636035
124E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11383546
125TBX20_22080862_ChIP-Seq_HEART_Mouse1.11258392
126TBX20_22328084_ChIP-Seq_HEART_Mouse1.11258392
127KDM2B_26808549_Chip-Seq_K562_Human1.11040436
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10569141
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10406032
130* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10242743
131ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09782447
132SPI1_23547873_ChIP-Seq_NB4_Human1.08776150
133NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08371872
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07460952
135HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07448310
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06742100
137* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06395563
138* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05026385
139LXR_22158963_ChIP-Seq_LIVER_Mouse1.04616036
140P300_27268052_Chip-Seq_Bcells_Human1.04277783
141* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04128422
142GATA2_19941826_ChIP-Seq_K562_Human1.03387415
143KDM5A_27292631_Chip-Seq_BREAST_Human1.03198079
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02783558
145TP53_22127205_ChIP-Seq_IMR90_Human1.01549318
146SA1_27219007_Chip-Seq_ERYTHROID_Human1.01421401
147MYC_18940864_ChIP-ChIP_HL60_Human1.00912399
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00492431
149* FOXP1_21924763_ChIP-Seq_HESCs_Human1.00273480
150* RARA_24833708_ChIP-Seq_LIVER_Mouse0.99583206
151PHF8_20622854_ChIP-Seq_HELA_Human0.99352427
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99155304
153TTF2_22483619_ChIP-Seq_HELA_Human0.99039085
154EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99022506
155GATA1_19941826_ChIP-Seq_K562_Human0.98594029
156* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98219106
157GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98074671
158* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98073671
159PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97959167
160RARB_24833708_ChIP-Seq_LIVER_Mouse0.97651131
161STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97492497
162CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96835654
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96753822
164VDR_24787735_ChIP-Seq_THP-1_Human0.96727135
165CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96429704
166* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94620634
167EZH2_22144423_ChIP-Seq_EOC_Human0.94139442
168NCOR1_26117541_ChIP-Seq_K562_Human0.93711701
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93101328
170DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91484748
171GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91483448
172* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91014134
173* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90821200
174HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89852708
175PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89628186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol5.10356534
2MP0002166_altered_tumor_susceptibility2.95783926
3MP0002138_abnormal_hepatobiliary_system2.95236078
4MP0002163_abnormal_gland_morphology2.93289131
5MP0003303_peritoneal_inflammation2.93199177
6MP0003283_abnormal_digestive_organ2.79924156
7* MP0009046_muscle_twitch2.70439071
8MP0005310_abnormal_salivary_gland2.68519284
9MP0001835_abnormal_antigen_presentation2.66278266
10MP0004510_myositis2.58770219
11MP0000013_abnormal_adipose_tissue2.52907272
12MP0006082_CNS_inflammation2.40550278
13MP0001873_stomach_inflammation2.39544165
14* MP0001800_abnormal_humoral_immune2.30524522
15MP0005671_abnormal_response_to2.28320470
16MP0001790_abnormal_immune_system2.21411162
17MP0005387_immune_system_phenotype2.21411162
18MP0003763_abnormal_thymus_physiology2.20927467
19MP0005360_urolithiasis2.15330480
20MP0004947_skin_inflammation2.13259555
21MP0003300_gastrointestinal_ulcer2.11137474
22MP0000685_abnormal_immune_system2.10741858
23MP0003787_abnormal_imprinting2.09887659
24MP0005058_abnormal_lysosome_morphology2.02866260
25MP0002006_tumorigenesis2.02240526
26MP0003436_decreased_susceptibility_to1.99697278
27MP0005670_abnormal_white_adipose1.98577990
28* MP0002452_abnormal_antigen_presenting1.95320844
29MP0005000_abnormal_immune_tolerance1.90497730
30MP0005623_abnormal_meninges_morphology1.86906928
31MP0003172_abnormal_lysosome_physiology1.83223472
32* MP0002420_abnormal_adaptive_immunity1.82515957
33* MP0002723_abnormal_immune_serum1.81681840
34* MP0001819_abnormal_immune_cell1.80639317
35MP0000569_abnormal_digit_pigmentation1.78385168
36MP0002933_joint_inflammation1.74135757
37MP0002419_abnormal_innate_immunity1.72546641
38MP0005025_abnormal_response_to1.72386661
39MP0000372_irregular_coat_pigmentation1.69441724
40MP0005464_abnormal_platelet_physiology1.65829072
41MP0003806_abnormal_nucleotide_metabolis1.64490906
42MP0005083_abnormal_biliary_tract1.63185532
43MP0003183_abnormal_peptide_metabolism1.61305734
44MP0003724_increased_susceptibility_to1.58954983
45MP0000003_abnormal_adipose_tissue1.56517445
46MP0009785_altered_susceptibility_to1.53057512
47MP0002398_abnormal_bone_marrow1.52076756
48MP0005171_absent_coat_pigmentation1.52058027
49MP0005220_abnormal_exocrine_pancreas1.50611484
50MP0003191_abnormal_cellular_cholesterol1.50194104
51MP0008057_abnormal_DNA_replication1.50102037
52MP0004145_abnormal_muscle_electrophysio1.49206580
53MP0001905_abnormal_dopamine_level1.47836391
54MP0002909_abnormal_adrenal_gland1.47170822
55MP0008961_abnormal_basal_metabolism1.47149081
56MP0009840_abnormal_foam_cell1.45837512
57MP0005076_abnormal_cell_differentiation1.45184661
58MP0003045_fibrosis1.44792043
59* MP0000716_abnormal_immune_system1.43624476
60MP0005379_endocrine/exocrine_gland_phen1.43106565
61MP0004130_abnormal_muscle_cell1.42293084
62MP0000015_abnormal_ear_pigmentation1.41164833
63MP0001944_abnormal_pancreas_morphology1.36160663
64MP0001529_abnormal_vocalization1.34798808
65MP0001845_abnormal_inflammatory_respons1.33927683
66MP0003091_abnormal_cell_migration1.32416802
67MP0003646_muscle_fatigue1.30897013
68MP0006276_abnormal_autonomic_nervous1.30258730
69MP0002722_abnormal_immune_system1.28929730
70MP0000689_abnormal_spleen_morphology1.26598404
71MP0002638_abnormal_pupillary_reflex1.25409074
72MP0005423_abnormal_somatic_nervous1.24347849
73MP0004084_abnormal_cardiac_muscle1.23901208
74MP0001533_abnormal_skeleton_physiology1.22380874
75MP0005375_adipose_tissue_phenotype1.22233740
76MP0002405_respiratory_system_inflammati1.21708237
77MP0000703_abnormal_thymus_morphology1.20999070
78MP0002009_preneoplasia1.20693040
79MP0008877_abnormal_DNA_methylation1.15065611
80MP0003111_abnormal_nucleus_morphology1.14439174
81MP0001348_abnormal_lacrimal_gland1.13818310
82MP0010155_abnormal_intestine_physiology1.12492358
83* MP0002429_abnormal_blood_cell1.11421318
84MP0001661_extended_life_span1.10353197
85MP0004859_abnormal_synaptic_plasticity1.09664433
86MP0008469_abnormal_protein_level1.08437593
87MP0003122_maternal_imprinting1.07838722
88MP0006292_abnormal_olfactory_placode1.06916728
89MP0002837_dystrophic_cardiac_calcinosis1.06119372
90MP0006035_abnormal_mitochondrial_morpho1.05797020
91MP0000747_muscle_weakness1.05100507
92MP0001502_abnormal_circadian_rhythm1.04853515
93MP0003566_abnormal_cell_adhesion1.04297008
94MP0005084_abnormal_gallbladder_morpholo1.04061954
95MP0006036_abnormal_mitochondrial_physio1.03834156
96MP0003279_aneurysm1.03584489
97MP0000371_diluted_coat_color1.02207753
98MP0009745_abnormal_behavioral_response1.02172417
99MP0004142_abnormal_muscle_tone1.01736310
100MP0002396_abnormal_hematopoietic_system1.01715296
101MP0001851_eye_inflammation1.01462384
102MP0000604_amyloidosis0.98724871
103MP0000751_myopathy0.98047589
104* MP0002272_abnormal_nervous_system0.97853207
105MP0000631_abnormal_neuroendocrine_gland0.97058519
106MP0000609_abnormal_liver_physiology0.95585395
107MP0003866_abnormal_defecation0.94892090
108MP0005197_abnormal_uvea_morphology0.94161734
109MP0010094_abnormal_chromosome_stability0.93016301
110MP0001270_distended_abdomen0.92990772
111MP0009333_abnormal_splenocyte_physiolog0.92113030
112MP0001879_abnormal_lymphatic_vessel0.91537098
113MP0001663_abnormal_digestive_system0.90102523
114MP0009643_abnormal_urine_homeostasis0.89507838
115MP0000343_altered_response_to0.88183807
116MP0005023_abnormal_wound_healing0.87281706
117MP0000249_abnormal_blood_vessel0.86004851
118MP0008874_decreased_physiological_sensi0.85275637
119MP0004185_abnormal_adipocyte_glucose0.84918186
120MP0002998_abnormal_bone_remodeling0.84543346
121MP0004036_abnormal_muscle_relaxation0.84531664
122MP0002139_abnormal_hepatobiliary_system0.83302901
123MP0005666_abnormal_adipose_tissue0.82478054
124MP0002148_abnormal_hypersensitivity_rea0.82419813
125MP0000026_abnormal_inner_ear0.82157631
126MP0005332_abnormal_amino_acid0.81768638
127MP0008438_abnormal_cutaneous_collagen0.80892013
128MP0005365_abnormal_bile_salt0.80321142
129MP0010329_abnormal_lipoprotein_level0.80215154
130MP0003329_amyloid_beta_deposits0.80076818
131MP0003705_abnormal_hypodermis_morpholog0.79373309
132MP0003828_pulmonary_edema0.79176560
133MP0002064_seizures0.79107163
134MP0005408_hypopigmentation0.78572591
135MP0003121_genomic_imprinting0.77697808
136MP0003221_abnormal_cardiomyocyte_apopto0.77377073
137MP0000358_abnormal_cell_content/0.76210529
138MP0002332_abnormal_exercise_endurance0.75730934
139MP0009763_increased_sensitivity_to0.75627803
140MP0002693_abnormal_pancreas_physiology0.75574660
141MP0000639_abnormal_adrenal_gland0.75258460
142MP0002136_abnormal_kidney_physiology0.73102347
143MP0002971_abnormal_brown_adipose0.72833444
144MP0002928_abnormal_bile_duct0.72363062
145MP0003786_premature_aging0.72340573
146MP0008058_abnormal_DNA_repair0.72222608
147MP0003693_abnormal_embryo_hatching0.69154704
148MP0005535_abnormal_body_temperature0.68434444
149MP0001919_abnormal_reproductive_system0.67920986
150* MP0002083_premature_death0.66747364
151MP0002557_abnormal_social/conspecific_i0.65740335
152MP0003077_abnormal_cell_cycle0.65579677
153MP0002160_abnormal_reproductive_system0.64023873
154MP0003137_abnormal_impulse_conducting0.62263179
155MP0002063_abnormal_learning/memory/cond0.62210511
156MP0002210_abnormal_sex_determination0.61626976
157MP0002019_abnormal_tumor_incidence0.61017148
158MP0005551_abnormal_eye_electrophysiolog0.60497415
159MP0003635_abnormal_synaptic_transmissio0.60335919
160MP0004924_abnormal_behavior0.60122004

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)7.39935817
2Recurrent sinusitis (HP:0011108)5.81713988
3IgA deficiency (HP:0002720)4.92966153
4Squamous cell carcinoma (HP:0002860)4.64510647
5Emphysema (HP:0002097)4.51180372
6Lymphopenia (HP:0001888)4.08849920
7Abnormality of cells of the lymphoid lineage (HP:0012140)3.77893956
8Anomalous pulmonary venous return (HP:0010772)3.73950454
9Elevated erythrocyte sedimentation rate (HP:0003565)3.62079341
10Recurrent pneumonia (HP:0006532)3.53607664
11Abnormality of the odontoid process (HP:0003310)3.45021973
12Recurrent cutaneous fungal infections (HP:0011370)3.41541907
13Chronic mucocutaneous candidiasis (HP:0002728)3.41541907
143-Methylglutaconic aciduria (HP:0003535)3.39058341
15Eczematoid dermatitis (HP:0000976)3.36170530
16Recurrent lower respiratory tract infections (HP:0002783)3.24951762
17IgG deficiency (HP:0004315)3.23885428
18Abnormal mitochondria in muscle tissue (HP:0008316)3.22587702
19Colitis (HP:0002583)3.19151516
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18542675
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18542675
22Abnormality of the pulmonary veins (HP:0011718)3.18352505
23Recurrent bronchitis (HP:0002837)3.15993971
24Hepatocellular necrosis (HP:0001404)3.12689193
25Agammaglobulinemia (HP:0004432)3.08034392
26Acute necrotizing encephalopathy (HP:0006965)3.07058452
27Hypercortisolism (HP:0001578)3.04716320
28Pseudobulbar signs (HP:0002200)3.02434268
29Recurrent fungal infections (HP:0002841)3.02387594
30Recurrent abscess formation (HP:0002722)2.98885317
31Basal cell carcinoma (HP:0002671)2.92369863
32Abnormal gallbladder physiology (HP:0012438)2.91508159
33Cholecystitis (HP:0001082)2.91508159
34Dry hair (HP:0011359)2.85600938
35Hepatic necrosis (HP:0002605)2.85252834
36Inflammation of the large intestine (HP:0002037)2.82455747
37Mitochondrial inheritance (HP:0001427)2.81006384
38Striae distensae (HP:0001065)2.80882640
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.79346891
40Recurrent skin infections (HP:0001581)2.79146711
41Verrucae (HP:0200043)2.69688155
42Papilloma (HP:0012740)2.69688155
43Abnormal number of erythroid precursors (HP:0012131)2.68649304
44Recurrent viral infections (HP:0004429)2.63334510
45Long toe (HP:0010511)2.63262572
46Recurrent bacterial skin infections (HP:0005406)2.62523176
47Gastrointestinal inflammation (HP:0004386)2.60403452
48Progressive macrocephaly (HP:0004481)2.59077115
49B lymphocytopenia (HP:0010976)2.58934020
50Abnormality of B cell number (HP:0010975)2.58934020
51Mesangial abnormality (HP:0001966)2.58637864
52Abnormality of T cell number (HP:0011839)2.57428667
53Vacuolated lymphocytes (HP:0001922)2.56155339
54Nonimmune hydrops fetalis (HP:0001790)2.55967318
55Hypertensive crisis (HP:0100735)2.55301886
56Axonal loss (HP:0003447)2.54892300
57Increased CSF lactate (HP:0002490)2.53535088
58Increased intramyocellular lipid droplets (HP:0012240)2.53207653
59Chronic sinusitis (HP:0011109)2.51423349
60Restrictive lung disease (HP:0002091)2.50685024
61Hematochezia (HP:0002573)2.50470347
62Increased muscle lipid content (HP:0009058)2.48496264
63Spontaneous hematomas (HP:0007420)2.47772135
64Lipid accumulation in hepatocytes (HP:0006561)2.46423864
65T lymphocytopenia (HP:0005403)2.46356934
66Progressive muscle weakness (HP:0003323)2.46027602
67Abnormality of cells of the erythroid lineage (HP:0012130)2.45144762
68Pustule (HP:0200039)2.44975028
69Dysostosis multiplex (HP:0000943)2.44640213
70Acute encephalopathy (HP:0006846)2.44284117
71Poikiloderma (HP:0001029)2.43880045
72Loss of speech (HP:0002371)2.40537297
73Mucopolysacchariduria (HP:0008155)2.38701647
74Urinary glycosaminoglycan excretion (HP:0003541)2.38701647
75Nasal polyposis (HP:0100582)2.38258398
76Severe combined immunodeficiency (HP:0004430)2.37425383
77Cellulitis (HP:0100658)2.35299548
78Upper limb muscle weakness (HP:0003484)2.34251496
79Exercise intolerance (HP:0003546)2.34210040
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33574600
81Hyperinsulinemic hypoglycemia (HP:0000825)2.32357027
82Myoglobinuria (HP:0002913)2.29543075
83Growth hormone excess (HP:0000845)2.27112857
84Microvesicular hepatic steatosis (HP:0001414)2.26555740
85Cerebral hemorrhage (HP:0001342)2.26208209
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24885231
87Dicarboxylic aciduria (HP:0003215)2.24885231
88Meningitis (HP:0001287)2.24685397
89Increased hepatocellular lipid droplets (HP:0006565)2.24417745
90Hyperthyroidism (HP:0000836)2.24390619
91Conical tooth (HP:0000698)2.22546851
92Periodontitis (HP:0000704)2.21411518
93Abnormality of the nasal mucosa (HP:0000433)2.21247603
94Recurrent otitis media (HP:0000403)2.20062459
95Muscle stiffness (HP:0003552)2.19585043
96Hemiparesis (HP:0001269)2.19479671
97Asymmetric septal hypertrophy (HP:0001670)2.18079346
98Abnormality of glycolysis (HP:0004366)2.16536813
99Cerebral aneurysm (HP:0004944)2.16307982
100Hypergammaglobulinemia (HP:0010702)2.16242011
101Leukopenia (HP:0001882)2.15276155
102Combined immunodeficiency (HP:0005387)2.13794228
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12670577
104Abnormality of polysaccharide metabolism (HP:0011012)2.12670577
105Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12670577
106Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12609074
107Cortical visual impairment (HP:0100704)2.10472030
108Chronic otitis media (HP:0000389)2.09804230
109Abnormal delayed hypersensitivity skin test (HP:0002963)2.09024597
110Myositis (HP:0100614)2.08894329
111Neutropenia (HP:0001875)2.06379376
112Ragged-red muscle fibers (HP:0003200)2.06081529
113Increased serum lactate (HP:0002151)2.05935043
114Onycholysis (HP:0001806)2.03622076
115Skin rash (HP:0000988)2.03296342
116Cervical subluxation (HP:0003308)2.03156381
117Posterior subcapsular cataract (HP:0007787)2.01294425
118Neuroendocrine neoplasm (HP:0100634)1.99382403
119Increased connective tissue (HP:0009025)1.99233702
120Pheochromocytoma (HP:0002666)1.98847809
121Vasculitis (HP:0002633)1.98114102
122Thyroiditis (HP:0100646)1.97754342
123Stridor (HP:0010307)1.97480254
124Cerebral edema (HP:0002181)1.96439941
125Recurrent gram-negative bacterial infections (HP:0005420)1.96421126
126Emotional lability (HP:0000712)1.96402473
127Abnormality of T cells (HP:0002843)1.96301656
128Entropion (HP:0000621)1.95308319
129Exercise-induced myalgia (HP:0003738)1.93681387
130IgM deficiency (HP:0002850)1.93391520
131Breast hypoplasia (HP:0003187)1.92708815
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91723390
133Lactic acidosis (HP:0003128)1.91472720
134Chronic diarrhea (HP:0002028)1.91397597
135Ocular albinism (HP:0001107)1.90148484
136Stomatitis (HP:0010280)1.89991110
137Congenital stationary night blindness (HP:0007642)1.89821727
138Impaired proprioception (HP:0010831)1.89622759
139Birth length less than 3rd percentile (HP:0003561)1.88200840
140Spondylolisthesis (HP:0003302)1.88141218
141Supranuclear gaze palsy (HP:0000605)1.87672175
142Premature loss of primary teeth (HP:0006323)1.87326974
143Sepsis (HP:0100806)1.87274024
144Autoimmune thrombocytopenia (HP:0001973)1.85714621
145Hypoglycemic seizures (HP:0002173)1.85318152
146Autoimmune hemolytic anemia (HP:0001890)1.84715896
147Abnormality of homocysteine metabolism (HP:0010919)1.83083357
148Homocystinuria (HP:0002156)1.83083357
149Mediastinal lymphadenopathy (HP:0100721)1.83068782
150Increased density of long bones (HP:0006392)1.82607480
151Hemoptysis (HP:0002105)1.82121003
152Osteomyelitis (HP:0002754)1.81840840
153Abnormality of T cell physiology (HP:0011840)1.81730599
154Chronic obstructive pulmonary disease (HP:0006510)1.81544394
155Obstructive lung disease (HP:0006536)1.81544394
156Abnormality of fatty-acid metabolism (HP:0004359)1.80334099
157Carpal bone hypoplasia (HP:0001498)1.79473563
158Aplasia/hypoplasia of the uterus (HP:0008684)1.78593579
159Bronchiectasis (HP:0002110)1.77098590
160Urticaria (HP:0001025)1.76655028
161Increased IgM level (HP:0003496)1.75854114
162Leukocytosis (HP:0001974)1.75684131
163Severe muscular hypotonia (HP:0006829)1.72952046
164Mitral stenosis (HP:0001718)1.72926959
165Centrally nucleated skeletal muscle fibers (HP:0003687)1.72812094
166Gingivitis (HP:0000230)1.72646572
167Abnormal foot bone ossification (HP:0010675)1.72524286
168Tetraparesis (HP:0002273)1.72509507
169Rapidly progressive (HP:0003678)1.72365173
170Hyporeflexia of lower limbs (HP:0002600)1.72025195
171Prominent metopic ridge (HP:0005487)1.71966141
172Abnormality of eosinophils (HP:0001879)1.71856122
173Bronchitis (HP:0012387)1.71599747
174Rhabdomyolysis (HP:0003201)1.71099460
175Spastic tetraparesis (HP:0001285)1.69192690
176Large for gestational age (HP:0001520)1.68841118
177Lymphoma (HP:0002665)1.68687607
178Villous atrophy (HP:0011473)1.67689722
179Abnormality of small intestinal villus morphology (HP:0011472)1.67689722
180Sparse scalp hair (HP:0002209)1.66748708
181Hypoplasia of the pons (HP:0012110)1.64879398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.50143255
2VRK14.39880386
3ZAK3.65548120
4CDK123.44367750
5MAP4K13.37568727
6CDK193.04806151
7TYK22.91839076
8ERN12.87112423
9TESK22.75054018
10RIPK12.63944369
11FGFR42.43930857
12KDR2.43650780
13DAPK32.33886821
14PKN22.12932134
15TRIB32.08323715
16RPS6KA52.07490158
17JAK12.03411121
18IKBKE2.02415715
19TBK12.01479570
20CAMK1G2.00777524
21TTN1.92809302
22MAP4K21.90102320
23SMG11.87765299
24ITK1.87357414
25CCNB11.82932582
26KIT1.78592710
27BRD41.75668162
28TXK1.68421291
29MAP3K141.67742834
30JAK31.67467354
31AURKA1.62544505
32TAOK31.61281785
33ZAP701.57572041
34SIK11.56025129
35MAPK151.55128631
36MAPKAPK51.52173090
37IRAK31.47564344
38TESK11.44880824
39GRK61.40341840
40SIK21.38561331
41STK161.38515463
42CAMK1D1.38167993
43TEC1.25999461
44VRK21.22281568
45FES1.20815747
46STK101.20729534
47CDC71.18195920
48ARAF1.16536237
49FGFR31.16436961
50LIMK11.15288750
51ICK1.11034115
52MARK31.06112788
53NTRK11.01420772
54PRKCH1.00472605
55KSR20.97004912
56HCK0.96835856
57MAP3K90.96721238
58RPS6KC10.94473159
59RPS6KL10.94473159
60CDK11A0.92372514
61EEF2K0.92179525
62SYK0.91988445
63MAP3K130.90736930
64STK40.89992541
65RET0.86604734
66CLK10.86503670
67BLK0.85322804
68RPS6KA60.85239206
69PRPF4B0.83894917
70TGFBR20.83757951
71BTK0.83446235
72EPHB10.82825643
73CDK150.81490106
74LCK0.81403454
75PKN10.81397273
76CSK0.80497353
77JAK20.78997194
78PASK0.78940838
79MST1R0.78348971
80CDK140.78285581
81MAPK70.77774211
82PNCK0.77611291
83PTK60.77140278
84RPS6KA20.76882770
85HIPK20.75987333
86SCYL20.74649293
87PRKG20.73975916
88PRKCQ0.73003578
89DDR20.72340582
90CSF1R0.72206333
91PIK3CG0.71943907
92FLT30.70712494
93CHEK20.70438498
94CDK180.69326168
95LMTK20.67845674
96AURKB0.65702149
97AKT20.65161457
98MAP3K20.64681870
99NME20.64373331
100CSNK1G30.63605370
101RIPK40.62359919
102PTK20.62161520
103PDK10.58260487
104FRK0.58120611
105GRK70.57660683
106RAF10.54744131
107MAPK110.52797540
108MAP3K100.50627670
109PRKD10.47988826
110LYN0.46894820
111CDK90.46346060
112MAP2K60.45297963
113PIM10.45135032
114OXSR10.44604033
115CSNK1G20.44420191
116BRAF0.43418336
117MAP2K30.42817159
118PIM20.42657472
119IRAK40.41646347
120CAMKK10.40819159
121BCKDK0.40794224
122CSNK1G10.40158576
123CDK40.39454827
124TNK20.38777943
125BMX0.38574708
126IGF1R0.38307279
127PHKG10.38281910
128PHKG20.38281910
129BUB10.37078519
130MUSK0.36680986
131IKBKB0.36030203
132MAPK120.35972972
133LRRK20.35441852
134MAPKAPK30.35165643
135ALK0.35164353
136PDPK10.34749776
137CDC42BPA0.34711635
138MTOR0.34578811
139PRKD20.33974103
140NEK90.33829976
141CDK30.32984026
142PRKCD0.31448100
143IRAK10.28886782
144CHUK0.28506504
145CDK50.28438051
146TAF10.27972881
147MAPK40.26717464
148UHMK10.25971569
149PRKAA10.25640041
150IRAK20.24429595
151ADRBK20.23228075
152CDK20.22595997

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.99501767
2Alcoholism_Homo sapiens_hsa050344.71692602
3Autoimmune thyroid disease_Homo sapiens_hsa053203.23980904
4Type I diabetes mellitus_Homo sapiens_hsa049403.13957447
5Primary immunodeficiency_Homo sapiens_hsa053402.95963585
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67224014
7Graft-versus-host disease_Homo sapiens_hsa053322.64225833
8* Intestinal immune network for IgA production_Homo sapiens_hsa046722.36931293
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.34129823
10Leishmaniasis_Homo sapiens_hsa051402.22749530
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11427936
12Osteoclast differentiation_Homo sapiens_hsa043802.05424864
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93709038
14B cell receptor signaling pathway_Homo sapiens_hsa046621.89837490
15T cell receptor signaling pathway_Homo sapiens_hsa046601.87988396
16Oxidative phosphorylation_Homo sapiens_hsa001901.86539449
17Protein export_Homo sapiens_hsa030601.79932249
18Antigen processing and presentation_Homo sapiens_hsa046121.78706432
19Viral carcinogenesis_Homo sapiens_hsa052031.74498450
20Parkinsons disease_Homo sapiens_hsa050121.73272365
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.70470354
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70215069
23Ribosome_Homo sapiens_hsa030101.59951317
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.58058116
25Homologous recombination_Homo sapiens_hsa034401.54111513
26Caffeine metabolism_Homo sapiens_hsa002321.52953597
27Measles_Homo sapiens_hsa051621.52701683
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51926641
29Fatty acid degradation_Homo sapiens_hsa000711.43440221
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40477634
31Toxoplasmosis_Homo sapiens_hsa051451.38520151
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36801419
33DNA replication_Homo sapiens_hsa030301.35452636
34Lysosome_Homo sapiens_hsa041421.32507084
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32310093
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28519755
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27372858
38Type II diabetes mellitus_Homo sapiens_hsa049301.25426149
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.24540471
40Malaria_Homo sapiens_hsa051441.22873772
41Viral myocarditis_Homo sapiens_hsa054161.22577804
42Staphylococcus aureus infection_Homo sapiens_hsa051501.22457841
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21517064
44Tuberculosis_Homo sapiens_hsa051521.20685146
45VEGF signaling pathway_Homo sapiens_hsa043701.19610116
46Butanoate metabolism_Homo sapiens_hsa006501.18520750
47Insulin resistance_Homo sapiens_hsa049311.16654058
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15939790
49Apoptosis_Homo sapiens_hsa042101.14137197
50N-Glycan biosynthesis_Homo sapiens_hsa005101.10634547
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10043660
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06178788
53Sulfur relay system_Homo sapiens_hsa041221.05868730
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04511765
55Epstein-Barr virus infection_Homo sapiens_hsa051691.01478462
56PPAR signaling pathway_Homo sapiens_hsa033201.00715610
57Pertussis_Homo sapiens_hsa051331.00389051
58Fatty acid metabolism_Homo sapiens_hsa012121.00232171
59Cardiac muscle contraction_Homo sapiens_hsa042600.99586844
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96432639
61Fructose and mannose metabolism_Homo sapiens_hsa000510.96195182
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.94693222
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94326547
64One carbon pool by folate_Homo sapiens_hsa006700.93211819
65Herpes simplex infection_Homo sapiens_hsa051680.92593519
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91456850
67Legionellosis_Homo sapiens_hsa051340.89881634
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.89856815
69Huntingtons disease_Homo sapiens_hsa050160.87298242
70Base excision repair_Homo sapiens_hsa034100.87121896
71Pyruvate metabolism_Homo sapiens_hsa006200.85912709
72Hepatitis B_Homo sapiens_hsa051610.85327942
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84465071
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.82815950
75Salmonella infection_Homo sapiens_hsa051320.81637561
76Other glycan degradation_Homo sapiens_hsa005110.81465348
77ABC transporters_Homo sapiens_hsa020100.80935862
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80925991
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80253001
80Pancreatic cancer_Homo sapiens_hsa052120.77764455
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.77002068
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75765294
83Insulin signaling pathway_Homo sapiens_hsa049100.75342419
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75134163
85Phagosome_Homo sapiens_hsa041450.71782424
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69101239
87Vibrio cholerae infection_Homo sapiens_hsa051100.67923612
88Prolactin signaling pathway_Homo sapiens_hsa049170.67819969
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67150494
90Propanoate metabolism_Homo sapiens_hsa006400.67068154
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66232314
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.65417748
93Fanconi anemia pathway_Homo sapiens_hsa034600.65399279
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64522309
95Allograft rejection_Homo sapiens_hsa053300.64420361
96mTOR signaling pathway_Homo sapiens_hsa041500.62808200
97Estrogen signaling pathway_Homo sapiens_hsa049150.62603614
98Mismatch repair_Homo sapiens_hsa034300.62600479
99Glucagon signaling pathway_Homo sapiens_hsa049220.62484030
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61957347
101Platelet activation_Homo sapiens_hsa046110.61285526
102Amphetamine addiction_Homo sapiens_hsa050310.60324536
103Hematopoietic cell lineage_Homo sapiens_hsa046400.60033430
104Selenocompound metabolism_Homo sapiens_hsa004500.59699858
105Cocaine addiction_Homo sapiens_hsa050300.59650790
106Influenza A_Homo sapiens_hsa051640.59283626
107Hepatitis C_Homo sapiens_hsa051600.59221984
108Pyrimidine metabolism_Homo sapiens_hsa002400.58578385
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57849181
110Carbon metabolism_Homo sapiens_hsa012000.57253067
111Tyrosine metabolism_Homo sapiens_hsa003500.56864958
112* Chemokine signaling pathway_Homo sapiens_hsa040620.56673735
113TNF signaling pathway_Homo sapiens_hsa046680.55190201
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55162003
115Thyroid hormone synthesis_Homo sapiens_hsa049180.54253045
116Alzheimers disease_Homo sapiens_hsa050100.54028140
117Phenylalanine metabolism_Homo sapiens_hsa003600.53868151
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53792330
119HIF-1 signaling pathway_Homo sapiens_hsa040660.53630184
120African trypanosomiasis_Homo sapiens_hsa051430.53532492
121Folate biosynthesis_Homo sapiens_hsa007900.52438658
122Shigellosis_Homo sapiens_hsa051310.51624049
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51562154
124Asthma_Homo sapiens_hsa053100.51281132
125Nucleotide excision repair_Homo sapiens_hsa034200.51217129
126Amoebiasis_Homo sapiens_hsa051460.51163755
127Bile secretion_Homo sapiens_hsa049760.51003022
128Rheumatoid arthritis_Homo sapiens_hsa053230.50904997
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.50596904
130Pentose phosphate pathway_Homo sapiens_hsa000300.49917173
131Proteasome_Homo sapiens_hsa030500.49693016
132Focal adhesion_Homo sapiens_hsa045100.49661221
133HTLV-I infection_Homo sapiens_hsa051660.49516196
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49203556
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47956076
136Dilated cardiomyopathy_Homo sapiens_hsa054140.47823240
137Endocytosis_Homo sapiens_hsa041440.47753820
138Chronic myeloid leukemia_Homo sapiens_hsa052200.46867501
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44674929
140Nicotine addiction_Homo sapiens_hsa050330.43314766
141RNA degradation_Homo sapiens_hsa030180.41922140
142Spliceosome_Homo sapiens_hsa030400.41619083
143Biosynthesis of amino acids_Homo sapiens_hsa012300.40334850
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36630008
145Insulin secretion_Homo sapiens_hsa049110.35521839
146RNA polymerase_Homo sapiens_hsa030200.33667081
147Purine metabolism_Homo sapiens_hsa002300.26379530
148p53 signaling pathway_Homo sapiens_hsa041150.25786367
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18931679
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17127366
151Phototransduction_Homo sapiens_hsa047440.15305109
152Collecting duct acid secretion_Homo sapiens_hsa049660.15264110
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13468383
154Synaptic vesicle cycle_Homo sapiens_hsa047210.11228992
155Fatty acid elongation_Homo sapiens_hsa000620.09759933
156Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08964968
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08034239
158Galactose metabolism_Homo sapiens_hsa000520.07415669
159Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.06517725

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