CCR12P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.73504974
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.73504974
3positive regulation of gamma-delta T cell activation (GO:0046645)6.52372302
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.13052528
5negative T cell selection (GO:0043383)6.12432402
6negative thymic T cell selection (GO:0045060)6.08822471
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.91403299
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.82594966
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.72089775
10antigen processing and presentation of endogenous antigen (GO:0019883)5.61543254
11tolerance induction (GO:0002507)5.51692398
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.49396540
13regulation of gamma-delta T cell differentiation (GO:0045586)5.43149892
14positive T cell selection (GO:0043368)5.34503454
15response to interleukin-15 (GO:0070672)5.31234229
16regulation of gamma-delta T cell activation (GO:0046643)5.22750139
17leukocyte aggregation (GO:0070486)5.21895131
18thymic T cell selection (GO:0045061)5.14359608
19T cell selection (GO:0045058)5.11645178
20regulation of B cell receptor signaling pathway (GO:0050855)5.02919998
21positive thymic T cell selection (GO:0045059)4.97325027
22activated T cell proliferation (GO:0050798)4.73994951
23cellular response to interleukin-15 (GO:0071350)4.70762984
24regulation of T cell tolerance induction (GO:0002664)4.60808027
25positive regulation of granulocyte differentiation (GO:0030854)4.36011323
26T cell migration (GO:0072678)4.29116569
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.22951329
28negative regulation of T cell mediated immunity (GO:0002710)4.21153426
29regulation of interleukin-2 biosynthetic process (GO:0045076)4.07054160
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.99950542
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.99950542
32modulation by symbiont of host immune response (GO:0052553)3.99950542
33positive regulation by symbiont of host defense response (GO:0052509)3.99950542
34modulation by symbiont of host defense response (GO:0052031)3.99950542
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.99950542
36regulation of tolerance induction (GO:0002643)3.98042609
37regulation of isotype switching to IgG isotypes (GO:0048302)3.94530014
38regulation of alpha-beta T cell proliferation (GO:0046640)3.93041335
39positive regulation of tolerance induction (GO:0002645)3.91562273
40regulation of B cell differentiation (GO:0045577)3.85897518
41regulation of regulatory T cell differentiation (GO:0045589)3.78207478
42response to muramyl dipeptide (GO:0032495)3.71920717
43T cell homeostasis (GO:0043029)3.69760098
44negative regulation of leukocyte mediated immunity (GO:0002704)3.68866831
45interferon-gamma production (GO:0032609)3.63961072
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62685269
47detection of bacterium (GO:0016045)3.59281922
48alpha-beta T cell differentiation (GO:0046632)3.57328586
49detection of other organism (GO:0098543)3.52719149
50T cell receptor signaling pathway (GO:0050852)3.49696909
51positive regulation of T cell differentiation in thymus (GO:0033089)3.47697614
52cellular extravasation (GO:0045123)3.47679306
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.47322023
54natural killer cell differentiation (GO:0001779)3.46485890
55B cell receptor signaling pathway (GO:0050853)3.44647633
56regulation of natural killer cell mediated immunity (GO:0002715)3.41682697
57regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.41682697
58negative regulation of erythrocyte differentiation (GO:0045647)3.41535091
59antigen receptor-mediated signaling pathway (GO:0050851)3.38497004
60NIK/NF-kappaB signaling (GO:0038061)3.36604847
61positive regulation of alpha-beta T cell proliferation (GO:0046641)3.34277486
62positive regulation of interleukin-2 production (GO:0032743)3.32079784
63negative regulation of interleukin-12 production (GO:0032695)3.31401400
64positive regulation of B cell differentiation (GO:0045579)3.30636817
65alpha-beta T cell activation (GO:0046631)3.30071001
66mucosal-associated lymphoid tissue development (GO:0048537)3.29014148
67Peyers patch development (GO:0048541)3.29014148
68negative regulation of phagocytosis (GO:0050765)3.28315511
69myeloid dendritic cell differentiation (GO:0043011)3.27451878
70regulation of granulocyte differentiation (GO:0030852)3.21272036
71lymphocyte homeostasis (GO:0002260)3.17806410
72negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16564763
73negative regulation of T-helper cell differentiation (GO:0045623)3.16564763
74mast cell activation (GO:0045576)3.15626245
75myeloid dendritic cell activation (GO:0001773)3.14963314
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.14288652
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11760408
78respiratory burst (GO:0045730)3.11126172
79response to laminar fluid shear stress (GO:0034616)3.09060099
80regulation of alpha-beta T cell activation (GO:0046634)3.08947215
81regulation of T cell mediated cytotoxicity (GO:0001914)3.02711962
82type I interferon signaling pathway (GO:0060337)3.02399135
83cellular response to type I interferon (GO:0071357)3.02399135
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01630479
85response to type I interferon (GO:0034340)3.01157738
86signal complex assembly (GO:0007172)2.98793356
87positive regulation of interleukin-4 production (GO:0032753)2.97876865
88macrophage activation involved in immune response (GO:0002281)2.97270704
89T cell differentiation (GO:0030217)2.97014942
90regulation of interleukin-4 production (GO:0032673)2.96151147
91histone H3-K36 demethylation (GO:0070544)2.94724909
92negative regulation of type 2 immune response (GO:0002829)2.93130611
93cellular response to interleukin-4 (GO:0071353)2.92177595
94negative regulation of interleukin-6 production (GO:0032715)2.90122362
95CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90005808
96positive regulation of isotype switching (GO:0045830)2.89942139
97regulation of isotype switching (GO:0045191)2.89336416
98negative regulation of glycoprotein biosynthetic process (GO:0010561)2.89319256
99response to interleukin-4 (GO:0070670)2.86749727
100positive regulation of humoral immune response (GO:0002922)2.86171178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.21175320
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.45535891
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.12310049
4RUNX_20019798_ChIP-Seq_JUKART_Human3.63161240
5MYC_22102868_ChIP-Seq_BL_Human3.51458579
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39853058
7MAF_26560356_Chip-Seq_TH1_Human3.13751204
8MYB_26560356_Chip-Seq_TH2_Human3.02102086
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98368344
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95281415
11UTX_26944678_Chip-Seq_JUKART_Human2.83274366
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.81578279
13VDR_21846776_ChIP-Seq_THP-1_Human2.77584808
14MYB_26560356_Chip-Seq_TH1_Human2.73535965
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62877698
16MAF_26560356_Chip-Seq_TH2_Human2.56080788
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51970230
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51400392
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.48061363
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46423502
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.43901152
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39387924
23TCF7_22412390_ChIP-Seq_EML_Mouse2.38620455
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.38400538
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34376460
26KDM2B_26808549_Chip-Seq_DND41_Human2.28221494
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.24651670
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22770569
29SPI1_23547873_ChIP-Seq_NB4_Human2.19027699
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15653184
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15536201
32SCL_19346495_ChIP-Seq_HPC-7_Human2.15513327
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.13791159
34VDR_24763502_ChIP-Seq_THP-1_Human2.12175178
35GATA3_27048872_Chip-Seq_THYMUS_Human2.09312674
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06959886
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06265352
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01858906
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98496395
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98075900
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.87331475
42SPI1_23127762_ChIP-Seq_K562_Human1.86172172
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83658902
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82292633
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81816665
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80002897
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.77894632
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.76104849
49CIITA_25753668_ChIP-Seq_RAJI_Human1.75745211
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71257161
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54804335
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50034805
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46472716
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.43158784
55GATA3_26560356_Chip-Seq_TH2_Human1.42562661
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42423705
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28486242
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27616377
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25973677
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25409007
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22696047
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21935968
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20099158
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16721990
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.16596566
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16447927
67PU_27001747_Chip-Seq_BMDM_Mouse1.13883060
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12988566
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11573051
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11118383
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09209700
72VDR_24787735_ChIP-Seq_THP-1_Human1.06787279
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06694896
74NCOR1_26117541_ChIP-Seq_K562_Human1.05921355
75LXR_22292898_ChIP-Seq_THP-1_Human1.03251614
76RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03174186
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02979056
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02253804
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01451965
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01020382
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01008345
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00956708
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.00832878
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97240721
85CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96592826
86SA1_27219007_Chip-Seq_ERYTHROID_Human0.93766503
87BCOR_27268052_Chip-Seq_Bcells_Human0.89420139
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88588222
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87104840
90BCL6_27268052_Chip-Seq_Bcells_Human0.85832644
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83887579
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83780188
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83497697
94SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83206600
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81492930
96GATA1_19941826_ChIP-Seq_K562_Human0.81385884
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79936094
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.79840659
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77319949
100VDR_23849224_ChIP-Seq_CD4+_Human0.77176189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.06751471
2MP0003436_decreased_susceptibility_to3.94585102
3MP0005671_abnormal_response_to3.57257028
4MP0003724_increased_susceptibility_to3.55567712
5MP0001800_abnormal_humoral_immune3.27404326
6MP0001835_abnormal_antigen_presentation3.09734583
7MP0003303_peritoneal_inflammation3.09183161
8MP0009333_abnormal_splenocyte_physiolog3.08741094
9MP0003300_gastrointestinal_ulcer2.98969245
10MP0005387_immune_system_phenotype2.91852950
11MP0001790_abnormal_immune_system2.91852950
12MP0005000_abnormal_immune_tolerance2.91726729
13MP0000685_abnormal_immune_system2.77324424
14MP0002420_abnormal_adaptive_immunity2.68982168
15MP0002723_abnormal_immune_serum2.66360848
16MP0001819_abnormal_immune_cell2.64540188
17MP0000703_abnormal_thymus_morphology2.62675804
18MP0005025_abnormal_response_to2.49582539
19MP0002452_abnormal_antigen_presenting2.49220283
20MP0002398_abnormal_bone_marrow2.48244536
21MP0002419_abnormal_innate_immunity2.34877427
22MP0002405_respiratory_system_inflammati2.32074882
23MP0001873_stomach_inflammation2.31546809
24MP0000716_abnormal_immune_system2.25061876
25MP0003866_abnormal_defecation2.22341598
26MP0004381_abnormal_hair_follicle2.17051216
27MP0010155_abnormal_intestine_physiology2.08274776
28MP0009785_altered_susceptibility_to2.04690874
29MP0002722_abnormal_immune_system2.04352314
30MP0000689_abnormal_spleen_morphology2.03783577
31MP0005451_abnormal_body_composition1.94894740
32MP0004947_skin_inflammation1.94881464
33MP0002396_abnormal_hematopoietic_system1.89070204
34MP0002148_abnormal_hypersensitivity_rea1.86161629
35MP0005310_abnormal_salivary_gland1.84583020
36MP0002429_abnormal_blood_cell1.77121553
37MP0006082_CNS_inflammation1.75523108
38MP0005464_abnormal_platelet_physiology1.69510474
39MP0001845_abnormal_inflammatory_respons1.57832322
40MP0000465_gastrointestinal_hemorrhage1.55696387
41MP0001533_abnormal_skeleton_physiology1.54980560
42MP0002009_preneoplasia1.50425539
43MP0001851_eye_inflammation1.49448328
44MP0003828_pulmonary_edema1.44940035
45MP0002138_abnormal_hepatobiliary_system1.44714111
46MP0002166_altered_tumor_susceptibility1.39964323
47MP0008260_abnormal_autophagy1.33058868
48MP0000490_abnormal_crypts_of1.29914589
49MP0002132_abnormal_respiratory_system1.27169586
50MP0002933_joint_inflammation1.26308925
51MP0005075_abnormal_melanosome_morpholog1.24474559
52MP0004510_myositis1.22052932
53MP0008469_abnormal_protein_level1.18736010
54MP0009278_abnormal_bone_marrow1.18224703
55MP0002277_abnormal_respiratory_mucosa1.17462564
56MP0001663_abnormal_digestive_system1.07738541
57MP0008995_early_reproductive_senescence1.07464608
58MP0000858_altered_metastatic_potential1.02482227
59MP0002998_abnormal_bone_remodeling1.01179152
60MP0008961_abnormal_basal_metabolism1.00818996
61MP0003172_abnormal_lysosome_physiology1.00778906
62MP0004808_abnormal_hematopoietic_stem1.00674280
63MP0003191_abnormal_cellular_cholesterol0.99931633
64MP0001348_abnormal_lacrimal_gland0.96624132
65MP0002006_tumorigenesis0.93384888
66MP0002254_reproductive_system_inflammat0.90511125
67MP0009764_decreased_sensitivity_to0.83566067
68MP0004130_abnormal_muscle_cell0.78360598
69MP0000015_abnormal_ear_pigmentation0.76760861
70MP0001853_heart_inflammation0.74810535
71MP0003221_abnormal_cardiomyocyte_apopto0.74745904
72MP0004883_abnormal_blood_vessel0.74625535
73MP0002019_abnormal_tumor_incidence0.74059496
74MP0001986_abnormal_taste_sensitivity0.71554673
75MP0002928_abnormal_bile_duct0.68533698
76MP0001545_abnormal_hematopoietic_system0.67932228
77MP0005397_hematopoietic_system_phenotyp0.67932228
78MP0009765_abnormal_xenobiotic_induced0.64199778
79MP0005381_digestive/alimentary_phenotyp0.62779740
80MP0003045_fibrosis0.61809228
81MP0003091_abnormal_cell_migration0.59201316
82MP0009763_increased_sensitivity_to0.56393059
83MP0008004_abnormal_stomach_pH0.55789029
84MP0003943_abnormal_hepatobiliary_system0.53230636
85MP0002693_abnormal_pancreas_physiology0.52365670
86MP0003448_altered_tumor_morphology0.50913321
87MP0002163_abnormal_gland_morphology0.50269568
88MP0005390_skeleton_phenotype0.50054274
89MP0000604_amyloidosis0.49929333
90MP0001919_abnormal_reproductive_system0.49201879
91MP0003795_abnormal_bone_structure0.48816728
92MP0008569_lethality_at_weaning0.46759640
93MP0008057_abnormal_DNA_replication0.46618955
94MP0000470_abnormal_stomach_morphology0.46099733
95MP0005535_abnormal_body_temperature0.43931882
96MP0001764_abnormal_homeostasis0.43080756
97MP0005166_decreased_susceptibility_to0.42218734
98MP0003787_abnormal_imprinting0.41918667
99MP0009115_abnormal_fat_cell0.41390455
100MP0008874_decreased_physiological_sensi0.39727413

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.47797606
2Stomatitis (HP:0010280)5.80926432
3Abnormal delayed hypersensitivity skin test (HP:0002963)5.03969970
4T lymphocytopenia (HP:0005403)4.99116759
5Panhypogammaglobulinemia (HP:0003139)4.93242608
6Elevated erythrocyte sedimentation rate (HP:0003565)4.92118310
7Myositis (HP:0100614)4.57842745
8Abnormality of T cell number (HP:0011839)4.55307509
9Recurrent fungal infections (HP:0002841)4.43888411
10Pustule (HP:0200039)4.34149182
11Recurrent bacterial skin infections (HP:0005406)4.15531711
12Recurrent abscess formation (HP:0002722)4.07002998
13Mediastinal lymphadenopathy (HP:0100721)3.99880787
14Abnormality of T cells (HP:0002843)3.97738170
15Retrobulbar optic neuritis (HP:0100654)3.88603933
16Optic neuritis (HP:0100653)3.88603933
17Orchitis (HP:0100796)3.87695413
18Abnormality of macrophages (HP:0004311)3.78221698
19Encephalitis (HP:0002383)3.73664237
20Increased IgE level (HP:0003212)3.72636638
21Meningitis (HP:0001287)3.71643964
22Gastrointestinal infarctions (HP:0005244)3.58972601
23Recurrent viral infections (HP:0004429)3.58126675
24Spontaneous hematomas (HP:0007420)3.56902666
25Severe combined immunodeficiency (HP:0004430)3.53139177
26Recurrent gram-negative bacterial infections (HP:0005420)3.53134742
27Lymphopenia (HP:0001888)3.45989214
28IgM deficiency (HP:0002850)3.43464877
29Chronic mucocutaneous candidiasis (HP:0002728)3.42755107
30Recurrent cutaneous fungal infections (HP:0011370)3.42755107
31Increased IgM level (HP:0003496)3.40977456
32Vasculitis (HP:0002633)3.35927728
33Granulocytopenia (HP:0001913)3.29347546
34Prolonged bleeding time (HP:0003010)3.27131829
35Hypochromic anemia (HP:0001931)3.26364276
36Obstructive lung disease (HP:0006536)3.24429636
37Chronic obstructive pulmonary disease (HP:0006510)3.24429636
38Abnormality of cells of the lymphoid lineage (HP:0012140)3.16234285
39Hypochromic microcytic anemia (HP:0004840)3.15090113
40Gastrointestinal inflammation (HP:0004386)3.14069402
41Inflammation of the large intestine (HP:0002037)3.08077477
42Leukocytosis (HP:0001974)3.07505212
43Recurrent skin infections (HP:0001581)3.05729318
44Abnormality of T cell physiology (HP:0011840)3.04765869
45Autoimmune hemolytic anemia (HP:0001890)2.95435600
46Chest pain (HP:0100749)2.92915475
47Papilledema (HP:0001085)2.84561134
48Eosinophilia (HP:0001880)2.83442577
49Abnormality of the fingertips (HP:0001211)2.75728774
50Abnormality of eosinophils (HP:0001879)2.72996489
51Combined immunodeficiency (HP:0005387)2.72576954
52Keratoconjunctivitis sicca (HP:0001097)2.72230415
53Basal cell carcinoma (HP:0002671)2.71132522
54Gingivitis (HP:0000230)2.69626627
55Recurrent bronchitis (HP:0002837)2.69170509
56Verrucae (HP:0200043)2.68918440
57Papilloma (HP:0012740)2.68918440
58Pulmonary infiltrates (HP:0002113)2.64369666
59Colitis (HP:0002583)2.60991048
60Slow saccadic eye movements (HP:0000514)2.55024812
61Microcytic anemia (HP:0001935)2.55024685
62Cellulitis (HP:0100658)2.50939236
63Epistaxis (HP:0000421)2.50356373
64IgG deficiency (HP:0004315)2.48638585
65Keratoconjunctivitis (HP:0001096)2.48029895
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43164300
67Agammaglobulinemia (HP:0004432)2.42801194
68Hemoptysis (HP:0002105)2.37841925
69Hypergammaglobulinemia (HP:0010702)2.33224390
70Urticaria (HP:0001025)2.28811646
71Anorexia (HP:0002039)2.28628964
72Abnormality of the columella (HP:0009929)2.25279430
73Lymphoma (HP:0002665)2.25102141
74Viral hepatitis (HP:0006562)2.19545605
75Pulmonary embolism (HP:0002204)2.19337121
76Joint swelling (HP:0001386)2.17167083
77Episodic fever (HP:0001954)2.15762060
78Sepsis (HP:0100806)2.15242141
79Chronic diarrhea (HP:0002028)2.07486729
80Hypoplasia of the thymus (HP:0000778)2.05824305
81Segmental peripheral demyelination/remyelination (HP:0003481)2.05341508
82Gingival bleeding (HP:0000225)2.03749927
83Gastrointestinal stroma tumor (HP:0100723)2.03642880
84Glomerulopathy (HP:0100820)2.00218948
85Recurrent sinusitis (HP:0011108)1.96902506
86Acute hepatic failure (HP:0006554)1.94404335
87Subacute progressive viral hepatitis (HP:0006572)1.92285204
88Petechiae (HP:0000967)1.91699168
89Osteomyelitis (HP:0002754)1.90061912
90Premature loss of primary teeth (HP:0006323)1.89994498
91Chronic otitis media (HP:0000389)1.87858740
92Arterial thrombosis (HP:0004420)1.87763651
93Anomalous pulmonary venous return (HP:0010772)1.85667314
94Abnormality of B cell number (HP:0010975)1.85306932
95IgA deficiency (HP:0002720)1.83233365
96Stomach cancer (HP:0012126)1.82814946
97Aplasia/Hypoplasia of the thymus (HP:0010515)1.80729188
98Abnormality of the pleura (HP:0002103)1.78319841
99Skin ulcer (HP:0200042)1.77228450
100Seborrheic dermatitis (HP:0001051)1.76329370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.14301143
2PRPF4B3.81353011
3TXK3.27087540
4RIPK42.88242852
5MAP3K102.69295327
6TYK22.23584378
7FES2.19094574
8ZAP702.14782894
9BTK2.12076765
10SIK32.09570022
11NLK2.08791655
12TNK22.06366212
13ITK2.02710208
14CSK1.99749328
15GRK61.96197328
16JAK31.89313797
17IRAK41.83889219
18PASK1.76354081
19HCK1.73102056
20IKBKE1.66449045
21MAP3K141.65236633
22EPHB11.59508443
23MAP2K31.59110887
24SIK21.58976075
25CAMKK21.58185501
26SMG11.58104334
27SYK1.57678301
28FGFR41.57090335
29MAP3K131.53478964
30BLK1.48509063
31LCK1.48305339
32CDK121.45331301
33CAMKK11.37830853
34MARK31.37113860
35MARK21.31204336
36TAOK11.28970050
37JAK11.27372290
38FGFR31.17322503
39ERN11.12109732
40LYN1.11325558
41TRIB31.10952961
42TAOK31.08743992
43TEC1.08235561
44MAP3K111.07277456
45JAK21.06934908
46MAP3K31.01296224
47HIPK21.00985323
48SIK10.97800532
49IKBKB0.97530175
50TAOK20.93455412
51TYRO30.91643013
52MAPK120.91544415
53BRD40.91225616
54MAP3K70.90162864
55MAP3K10.87483749
56MAPK70.86105064
57TBK10.85928043
58CDK40.84992585
59PDK10.83748787
60IRAK10.80320824
61ICK0.80241690
62PRKCQ0.79233910
63PRKD20.79047733
64YES10.74473926
65TESK20.72833239
66KSR20.67394943
67STK100.65766034
68SGK30.64158782
69IRAK20.62741842
70CAMK40.61737029
71PIM10.61374062
72DYRK1B0.60057903
73PRKCH0.57323537
74MAPK110.57246925
75PKN20.56765306
76CDK190.56643299
77CLK10.55439307
78FGR0.53851563
79CHUK0.53442566
80LRRK20.52472006
81FYN0.49793716
82CSF1R0.49684811
83EPHA30.48489579
84NTRK20.48196047
85MELK0.47270824
86STK110.46791962
87PTK60.46618946
88STK380.46529461
89SGK20.46090476
90RPS6KL10.46043118
91RPS6KC10.46043118
92CDC42BPA0.40473943
93CDK60.39592264
94RPS6KA60.39129277
95PDPK10.38967052
96RET0.38450739
97WNK10.37227268
98UHMK10.35769644
99KSR10.34748379
100PDGFRB0.31828944

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.72446783
2T cell receptor signaling pathway_Homo sapiens_hsa046603.06384218
3Osteoclast differentiation_Homo sapiens_hsa043802.59593976
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.52392941
5B cell receptor signaling pathway_Homo sapiens_hsa046622.44065818
6Acute myeloid leukemia_Homo sapiens_hsa052212.42530240
7Measles_Homo sapiens_hsa051622.23786848
8Allograft rejection_Homo sapiens_hsa053302.23536596
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.18698166
10Graft-versus-host disease_Homo sapiens_hsa053322.16445326
11Autoimmune thyroid disease_Homo sapiens_hsa053202.16196221
12Leishmaniasis_Homo sapiens_hsa051401.96753723
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.90438745
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85601182
15Hematopoietic cell lineage_Homo sapiens_hsa046401.73089548
16Non-small cell lung cancer_Homo sapiens_hsa052231.71355427
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.69772756
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69465091
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66746649
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61526966
21Chemokine signaling pathway_Homo sapiens_hsa040621.58406645
22Viral myocarditis_Homo sapiens_hsa054161.56605651
23Type I diabetes mellitus_Homo sapiens_hsa049401.55725295
24Herpes simplex infection_Homo sapiens_hsa051681.51064525
25Colorectal cancer_Homo sapiens_hsa052101.50826046
26Hepatitis B_Homo sapiens_hsa051611.49873638
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47712501
28TNF signaling pathway_Homo sapiens_hsa046681.38902707
29Chronic myeloid leukemia_Homo sapiens_hsa052201.36618204
30Antigen processing and presentation_Homo sapiens_hsa046121.36185004
31Tuberculosis_Homo sapiens_hsa051521.34433358
32Endometrial cancer_Homo sapiens_hsa052131.34310026
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.31875337
34Pancreatic cancer_Homo sapiens_hsa052121.30777882
35Influenza A_Homo sapiens_hsa051641.26986423
36Staphylococcus aureus infection_Homo sapiens_hsa051501.26835626
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24443040
38Toxoplasmosis_Homo sapiens_hsa051451.22710864
39VEGF signaling pathway_Homo sapiens_hsa043701.17687566
40Renal cell carcinoma_Homo sapiens_hsa052111.16973573
41Malaria_Homo sapiens_hsa051441.15285111
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14858561
43Prolactin signaling pathway_Homo sapiens_hsa049171.14516432
44Notch signaling pathway_Homo sapiens_hsa043301.11082303
45Epstein-Barr virus infection_Homo sapiens_hsa051691.06339407
46HTLV-I infection_Homo sapiens_hsa051661.04478080
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.04103430
48Thyroid cancer_Homo sapiens_hsa052161.03147318
49Platelet activation_Homo sapiens_hsa046111.02703143
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.02298892
51FoxO signaling pathway_Homo sapiens_hsa040681.02235423
52Hepatitis C_Homo sapiens_hsa051601.00277371
53mTOR signaling pathway_Homo sapiens_hsa041500.99570182
54Viral carcinogenesis_Homo sapiens_hsa052030.98555737
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97914510
56Apoptosis_Homo sapiens_hsa042100.93134264
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92666622
58Inositol phosphate metabolism_Homo sapiens_hsa005620.91873017
59Prostate cancer_Homo sapiens_hsa052150.87219298
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84675438
61African trypanosomiasis_Homo sapiens_hsa051430.82748276
62MAPK signaling pathway_Homo sapiens_hsa040100.80122910
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78874497
64Choline metabolism in cancer_Homo sapiens_hsa052310.78690323
65Legionellosis_Homo sapiens_hsa051340.77710012
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.74691480
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74281143
68ErbB signaling pathway_Homo sapiens_hsa040120.73579845
69Asthma_Homo sapiens_hsa053100.70874114
70Shigellosis_Homo sapiens_hsa051310.69883747
71Dorso-ventral axis formation_Homo sapiens_hsa043200.69618409
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.67594295
73Endocytosis_Homo sapiens_hsa041440.63388475
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63343904
75HIF-1 signaling pathway_Homo sapiens_hsa040660.62644544
76Long-term potentiation_Homo sapiens_hsa047200.61590309
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60907309
78Other glycan degradation_Homo sapiens_hsa005110.60288633
79Type II diabetes mellitus_Homo sapiens_hsa049300.57789459
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56216529
81Insulin resistance_Homo sapiens_hsa049310.56021477
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55686598
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54270845
84Glioma_Homo sapiens_hsa052140.54202749
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53480861
86GnRH signaling pathway_Homo sapiens_hsa049120.51368332
87Ras signaling pathway_Homo sapiens_hsa040140.50861586
88Rheumatoid arthritis_Homo sapiens_hsa053230.50418582
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.48709734
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47894103
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46967135
92Pertussis_Homo sapiens_hsa051330.45215213
93Phagosome_Homo sapiens_hsa041450.44592729
94Rap1 signaling pathway_Homo sapiens_hsa040150.44410143
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43388285
96Regulation of autophagy_Homo sapiens_hsa041400.40838424
97Salmonella infection_Homo sapiens_hsa051320.38518341
98Insulin signaling pathway_Homo sapiens_hsa049100.35728977
99Ribosome_Homo sapiens_hsa030100.35442799
100Cholinergic synapse_Homo sapiens_hsa047250.34797830

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