CCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.72677859
2neutrophil activation involved in immune response (GO:0002283)5.92148905
3detection of other organism (GO:0098543)5.06796641
4respiratory burst (GO:0045730)5.02811960
5regulation of gamma-delta T cell activation (GO:0046643)4.80541251
6detection of bacterium (GO:0016045)4.77987121
7immunoglobulin mediated immune response (GO:0016064)4.69734915
8regulation of B cell receptor signaling pathway (GO:0050855)4.63689559
9positive regulation by symbiont of host defense response (GO:0052509)4.60915215
10modulation by symbiont of host defense response (GO:0052031)4.60915215
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.60915215
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.60915215
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.60915215
14modulation by symbiont of host immune response (GO:0052553)4.60915215
15production of molecular mediator involved in inflammatory response (GO:0002532)4.57797359
16positive regulation of mast cell activation (GO:0033005)4.42937013
17regulation of gamma-delta T cell differentiation (GO:0045586)4.42166967
18Arp2/3 complex-mediated actin nucleation (GO:0034314)4.41541110
19neutrophil activation (GO:0042119)4.40411800
20leukocyte aggregation (GO:0070486)4.35416528
21response to interleukin-15 (GO:0070672)4.32909697
22detection of external biotic stimulus (GO:0098581)4.30954834
23negative regulation of lymphocyte mediated immunity (GO:0002707)4.30106234
24response to peptidoglycan (GO:0032494)4.28648763
25cellular extravasation (GO:0045123)4.25423103
26detection of molecule of bacterial origin (GO:0032490)4.19578292
27granulocyte activation (GO:0036230)4.19126825
28antigen processing and presentation of endogenous antigen (GO:0019883)4.10351371
29mast cell activation (GO:0045576)4.08720169
30antigen processing and presentation via MHC class Ib (GO:0002475)4.08161130
31interferon-gamma production (GO:0032609)4.07743237
32negative regulation of T cell mediated immunity (GO:0002710)4.07179073
33cellular response to interleukin-15 (GO:0071350)4.02836269
34myeloid cell activation involved in immune response (GO:0002275)3.95154706
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.94178384
36positive regulation of gamma-delta T cell activation (GO:0046645)3.93121219
37neutrophil mediated immunity (GO:0002446)3.91696077
38* negative regulation of leukocyte mediated immunity (GO:0002704)3.82743749
39macrophage activation involved in immune response (GO:0002281)3.82368525
40* T cell migration (GO:0072678)3.81209361
41detection of biotic stimulus (GO:0009595)3.79697378
42actin nucleation (GO:0045010)3.77427670
43regulation of T cell tolerance induction (GO:0002664)3.72585295
44lipoxygenase pathway (GO:0019372)3.67540784
45regulation of tolerance induction (GO:0002643)3.66555820
46regulation of interferon-beta biosynthetic process (GO:0045357)3.65326281
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64453661
48leukocyte migration involved in inflammatory response (GO:0002523)3.63787969
49regulation of mast cell activation (GO:0033003)3.60421767
50interferon-gamma-mediated signaling pathway (GO:0060333)3.58682644
51reactive oxygen species biosynthetic process (GO:1903409)3.57512950
52T cell selection (GO:0045058)3.57223335
53positive regulation of mast cell degranulation (GO:0043306)3.55691907
54positive regulation of mast cell activation involved in immune response (GO:0033008)3.55691907
55superoxide anion generation (GO:0042554)3.55362465
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.55280610
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55280610
58cellular response to zinc ion (GO:0071294)3.54973520
59B cell mediated immunity (GO:0019724)3.54426486
60leukocyte mediated cytotoxicity (GO:0001909)3.54110004
61positive regulation of interferon-alpha production (GO:0032727)3.51881747
62response to muramyl dipeptide (GO:0032495)3.47893800
63positive T cell selection (GO:0043368)3.47872599
64activated T cell proliferation (GO:0050798)3.46815214
65negative regulation of cell killing (GO:0031342)3.46657984
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46657984
67pinocytosis (GO:0006907)3.46219067
68positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.43242425
69myeloid dendritic cell activation (GO:0001773)3.43105775
70response to host (GO:0075136)3.42030528
71response to host defenses (GO:0052200)3.42030528
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.42030528
73* dendritic cell chemotaxis (GO:0002407)3.41693845
74positive regulation of antigen processing and presentation (GO:0002579)3.40938041
75negative regulation of phagocytosis (GO:0050765)3.40459425
76regulation of interferon-alpha production (GO:0032647)3.37106407
77regulation of B cell differentiation (GO:0045577)3.34336060
78regulation of mast cell degranulation (GO:0043304)3.33168103
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30057082
80regulation of T cell mediated cytotoxicity (GO:0001914)3.29972152
81thymic T cell selection (GO:0045061)3.29845623
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29327041
83lipopolysaccharide-mediated signaling pathway (GO:0031663)3.25868646
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.24694800
85positive regulation of cellular amide metabolic process (GO:0034250)3.23475189
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22064220
87positive regulation of tolerance induction (GO:0002645)3.20917889
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.20106450
89sequestering of actin monomers (GO:0042989)3.19652190
90tolerance induction (GO:0002507)3.17413040
91* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.17149642
92positive regulation of B cell differentiation (GO:0045579)3.16161526
93hydrogen peroxide biosynthetic process (GO:0050665)3.15808189
94positive regulation of T cell mediated cytotoxicity (GO:0001916)3.15225800
95regulation of antigen processing and presentation (GO:0002577)3.14435139
96myeloid leukocyte mediated immunity (GO:0002444)3.14407783
97myeloid leukocyte activation (GO:0002274)3.14254083
98mast cell degranulation (GO:0043303)3.11093047
99mast cell activation involved in immune response (GO:0002279)3.11093047
100positive regulation of macrophage differentiation (GO:0045651)3.10119693
101type I interferon signaling pathway (GO:0060337)3.09661656
102cellular response to type I interferon (GO:0071357)3.09661656
103myeloid dendritic cell differentiation (GO:0043011)3.09343455
104leukocyte degranulation (GO:0043299)3.09135809
105regulation of natural killer cell mediated immunity (GO:0002715)3.08873199
106regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.08873199
107response to type I interferon (GO:0034340)3.06813464
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.06005742
109B cell receptor signaling pathway (GO:0050853)3.04697818
110response to host immune response (GO:0052572)3.04288427
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04288427
112regulation of regulatory T cell differentiation (GO:0045589)3.04146223
113* regulation of alpha-beta T cell proliferation (GO:0046640)3.03919735
114regulation of mast cell activation involved in immune response (GO:0033006)3.01865590
115regulation of hypersensitivity (GO:0002883)3.01140551
116leukocyte cell-cell adhesion (GO:0007159)3.00891961
117positive regulation of granulocyte differentiation (GO:0030854)3.00418805
118* cellular defense response (GO:0006968)2.99960484
119microglial cell activation (GO:0001774)2.99711286
120defense response to protozoan (GO:0042832)2.98600833
121* regulation of leukocyte degranulation (GO:0043300)2.97512593
122response to protozoan (GO:0001562)2.97165849
123positive thymic T cell selection (GO:0045059)2.97008784
124regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.96911608
125negative regulation of interleukin-12 production (GO:0032695)2.96716980
126negative regulation of innate immune response (GO:0045824)2.96505250
127positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95594570
128positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.94936638
129negative thymic T cell selection (GO:0045060)2.93266190
130antigen receptor-mediated signaling pathway (GO:0050851)2.92542772
131negative regulation of myeloid cell apoptotic process (GO:0033033)2.92095970
132* dendritic cell migration (GO:0036336)2.90661195
133regulation of growth of symbiont in host (GO:0044126)2.88372465
134negative regulation of growth of symbiont in host (GO:0044130)2.88372465
135negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.88372465
136modulation of growth of symbiont involved in interaction with host (GO:0044144)2.88372465
137leukotriene metabolic process (GO:0006691)2.87437569
138negative T cell selection (GO:0043383)2.86990483
139cellular response to interferon-beta (GO:0035458)2.86841907
140macrophage activation (GO:0042116)2.86628045
141positive regulation of interleukin-1 beta secretion (GO:0050718)2.84991632
142* positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84467796
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.84386161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.44115716
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.38274990
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.52826344
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.40297236
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.32561949
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.17865712
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.12562009
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.01829780
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.00154254
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58016988
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.44534937
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.41157611
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14293971
14STAT4_19710469_ChIP-ChIP_TH1__Mouse3.08411326
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.94890245
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90309853
17SPI1_23547873_ChIP-Seq_NB4_Human2.63893786
18E2F7_22180533_ChIP-Seq_HELA_Human2.58457803
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44598581
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.44195671
21SCL_19346495_ChIP-Seq_HPC-7_Human2.41208951
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39391632
23MYB_26560356_Chip-Seq_TH2_Human2.38200207
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.35996325
25RUNX_20019798_ChIP-Seq_JUKART_Human2.34629466
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20548682
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12748169
28* RUNX1_22412390_ChIP-Seq_EML_Mouse2.11705769
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06314475
30VDR_24763502_ChIP-Seq_THP-1_Human2.01870753
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93394572
32MAF_26560356_Chip-Seq_TH1_Human1.92342379
33VDR_21846776_ChIP-Seq_THP-1_Human1.88626883
34* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.88102214
35PU_27001747_Chip-Seq_BMDM_Mouse1.87885272
36* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87513313
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84316967
38MYB_26560356_Chip-Seq_TH1_Human1.83076666
39SPI1_23127762_ChIP-Seq_K562_Human1.78812560
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75668484
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73070487
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70230148
43* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68363590
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67586386
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62835331
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60185155
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57532200
48VDR_24787735_ChIP-Seq_THP-1_Human1.52288662
49* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51427372
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46993699
51* UTX_26944678_Chip-Seq_JUKART_Human1.43544280
52CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42753601
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41557068
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39148738
55GATA3_27048872_Chip-Seq_THYMUS_Human1.37070614
56* GATA3_26560356_Chip-Seq_TH2_Human1.28356992
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24231774
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23340890
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22064026
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20581464
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20329774
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19131021
63* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18141173
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15036087
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13347410
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13109513
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12126673
68TCF7_22412390_ChIP-Seq_EML_Mouse1.09694410
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07275261
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06349615
71GATA1_19941826_ChIP-Seq_K562_Human1.05044963
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05024615
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.04438590
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.02726931
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01528279
76GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99223607
77GATA2_21666600_ChIP-Seq_HMVEC_Human0.98682701
78SMAD_19615063_ChIP-ChIP_OVARY_Human0.98302721
79MYC_22102868_ChIP-Seq_BL_Human0.98093534
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97519047
81MAF_26560356_Chip-Seq_TH2_Human0.95262419
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95260928
83CIITA_25753668_ChIP-Seq_RAJI_Human0.94713805
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94454637
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92718026
86BCL6_27268052_Chip-Seq_Bcells_Human0.91792463
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90573724
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.89090180
89LXR_22292898_ChIP-Seq_THP-1_Human0.85016549
90* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84296233
91BCOR_27268052_Chip-Seq_Bcells_Human0.83063357
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82989839
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80972203
94NCOR1_26117541_ChIP-Seq_K562_Human0.76619637
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76425792
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75779953
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75447841
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74796584
99SPI1_20517297_ChIP-Seq_HL60_Human0.74213662
100FOXM1_23109430_ChIP-Seq_U2OS_Human0.73789281
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73674549
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72998376
103EGR1_19032775_ChIP-ChIP_M12_Human0.71728610
104GATA1_22025678_ChIP-Seq_K562_Human0.70726091
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.69531346
106GATA2_19941826_ChIP-Seq_K562_Human0.66347182
107ETS1_22383799_ChIP-Seq_G1ME_Mouse0.64114144
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62508866
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.60742372
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.58471761
111KDM2B_26808549_Chip-Seq_DND41_Human0.56568774
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.55876237
113ELK1_19687146_ChIP-ChIP_HELA_Human0.55367153
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.54633268
115SMRT_27268052_Chip-Seq_Bcells_Human0.53834576
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.53550409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.15920304
2MP0003436_decreased_susceptibility_to3.98702169
3MP0005671_abnormal_response_to3.77331490
4* MP0002148_abnormal_hypersensitivity_rea3.61921772
5* MP0009785_altered_susceptibility_to3.48257265
6* MP0002419_abnormal_innate_immunity3.33608223
7* MP0005000_abnormal_immune_tolerance3.25727539
8* MP0005025_abnormal_response_to3.20391199
9MP0006082_CNS_inflammation2.95869260
10MP0000685_abnormal_immune_system2.87637949
11MP0001790_abnormal_immune_system2.85626402
12MP0005387_immune_system_phenotype2.85626402
13MP0003303_peritoneal_inflammation2.81989530
14* MP0002452_abnormal_antigen_presenting2.81068892
15MP0003724_increased_susceptibility_to2.80760880
16* MP0001800_abnormal_humoral_immune2.76535841
17* MP0002723_abnormal_immune_serum2.69187640
18* MP0001819_abnormal_immune_cell2.60522428
19* MP0002420_abnormal_adaptive_immunity2.60184185
20MP0002405_respiratory_system_inflammati2.34302666
21MP0002006_tumorigenesis2.29866892
22MP0002166_altered_tumor_susceptibility2.23221984
23MP0005464_abnormal_platelet_physiology2.22344392
24MP0001853_heart_inflammation2.14218522
25MP0001533_abnormal_skeleton_physiology1.97654709
26* MP0001845_abnormal_inflammatory_respons1.96208861
27MP0000858_altered_metastatic_potential1.92532617
28* MP0000716_abnormal_immune_system1.89497869
29* MP0002398_abnormal_bone_marrow1.87947990
30MP0005058_abnormal_lysosome_morphology1.85816803
31* MP0003448_altered_tumor_morphology1.82523860
32* MP0010155_abnormal_intestine_physiology1.81403461
33MP0005310_abnormal_salivary_gland1.80965424
34MP0004510_myositis1.80243919
35MP0003172_abnormal_lysosome_physiology1.71975867
36MP0009764_decreased_sensitivity_to1.70826805
37* MP0000343_altered_response_to1.70126736
38* MP0008469_abnormal_protein_level1.63325661
39MP0003763_abnormal_thymus_physiology1.60395495
40MP0003075_altered_response_to1.58395510
41MP0003300_gastrointestinal_ulcer1.56961358
42MP0002396_abnormal_hematopoietic_system1.56236620
43MP0004947_skin_inflammation1.55719415
44* MP0002429_abnormal_blood_cell1.52616057
45* MP0009333_abnormal_splenocyte_physiolog1.50560250
46MP0005174_abnormal_tail_pigmentation1.50100440
47* MP0000689_abnormal_spleen_morphology1.48949672
48* MP0002722_abnormal_immune_system1.48029873
49* MP0002998_abnormal_bone_remodeling1.38073879
50MP0000465_gastrointestinal_hemorrhage1.33761781
51MP0004782_abnormal_surfactant_physiolog1.26568753
52* MP0004883_abnormal_blood_vessel1.22357250
53MP0005397_hematopoietic_system_phenotyp1.18493044
54MP0001545_abnormal_hematopoietic_system1.18493044
55MP0001851_eye_inflammation1.16692095
56* MP0005166_decreased_susceptibility_to1.14650045
57MP0003828_pulmonary_edema1.13970476
58MP0001873_stomach_inflammation1.11366097
59MP0000569_abnormal_digit_pigmentation1.11143177
60MP0000490_abnormal_crypts_of1.08432984
61MP0009763_increased_sensitivity_to1.07109961
62MP0010307_abnormal_tumor_latency1.06489434
63MP0003183_abnormal_peptide_metabolism1.05875830
64MP0002933_joint_inflammation1.02294940
65MP0000703_abnormal_thymus_morphology1.01293755
66MP0003191_abnormal_cellular_cholesterol0.99354902
67MP0002009_preneoplasia0.98637605
68MP0002138_abnormal_hepatobiliary_system0.92516187
69MP0001986_abnormal_taste_sensitivity0.90289739
70MP0005076_abnormal_cell_differentiation0.89701527
71* MP0000249_abnormal_blood_vessel0.87635707
72MP0002277_abnormal_respiratory_mucosa0.87350866
73MP0005390_skeleton_phenotype0.87195260
74MP0004130_abnormal_muscle_cell0.86502282
75MP0005167_abnormal_blood-brain_barrier0.86188063
76* MP0003866_abnormal_defecation0.85179553
77MP0006054_spinal_hemorrhage0.82945062
78MP0004808_abnormal_hematopoietic_stem0.81857007
79MP0009278_abnormal_bone_marrow0.79947166
80MP0000015_abnormal_ear_pigmentation0.79636134
81MP0002132_abnormal_respiratory_system0.75161054
82* MP0003690_abnormal_glial_cell0.74994917
83* MP0003795_abnormal_bone_structure0.72575054
84MP0001663_abnormal_digestive_system0.70484774
85MP0003566_abnormal_cell_adhesion0.69441217
86MP0008057_abnormal_DNA_replication0.65815262
87* MP0005164_abnormal_response_to0.65583966
88MP0002019_abnormal_tumor_incidence0.65466470
89MP0000920_abnormal_myelination0.63528917
90* MP0000604_amyloidosis0.63320033
91MP0003221_abnormal_cardiomyocyte_apopto0.60094952
92MP0008874_decreased_physiological_sensi0.59724113
93MP0004381_abnormal_hair_follicle0.59046200
94MP0005388_respiratory_system_phenotype0.58852704
95MP0002133_abnormal_respiratory_system0.58852704
96MP0008004_abnormal_stomach_pH0.58844931
97MP0009765_abnormal_xenobiotic_induced0.58271477
98MP0005451_abnormal_body_composition0.56084538
99MP0000371_diluted_coat_color0.55265447
100MP0005075_abnormal_melanosome_morpholog0.54355613
101MP0003186_abnormal_redox_activity0.53462579
102MP0001958_emphysema0.51280660
103* MP0008873_increased_physiological_sensi0.50768786
104MP0003045_fibrosis0.50443325
105MP0008260_abnormal_autophagy0.49643490
106MP0002928_abnormal_bile_duct0.48289624
107MP0004484_altered_response_of0.47695762
108* MP0002136_abnormal_kidney_physiology0.47038423
109MP0003656_abnormal_erythrocyte_physiolo0.45678786
110MP0005584_abnormal_enzyme/coenzyme_acti0.45163563
111MP0001881_abnormal_mammary_gland0.43973703
112MP0003252_abnormal_bile_duct0.43942630
113MP0002877_abnormal_melanocyte_morpholog0.43567450
114MP0001765_abnormal_ion_homeostasis0.43212839
115MP0002693_abnormal_pancreas_physiology0.42648895

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.63123689
2Recurrent bacterial skin infections (HP:0005406)7.07933259
3Eczematoid dermatitis (HP:0000976)6.88903988
4Recurrent gram-negative bacterial infections (HP:0005420)5.64668678
5Myositis (HP:0100614)5.31375164
6Orchitis (HP:0100796)4.84163037
7Retrobulbar optic neuritis (HP:0100654)4.78071092
8Optic neuritis (HP:0100653)4.78071092
9Elevated erythrocyte sedimentation rate (HP:0003565)4.63314373
10Abnormality of macrophages (HP:0004311)4.55969177
11Recurrent skin infections (HP:0001581)4.51795430
12Obstructive lung disease (HP:0006536)4.30739927
13Chronic obstructive pulmonary disease (HP:0006510)4.30739927
14Mediastinal lymphadenopathy (HP:0100721)4.25389284
15Recurrent fungal infections (HP:0002841)4.19203868
16Gingivitis (HP:0000230)4.08206530
17Systemic lupus erythematosus (HP:0002725)3.96234965
18Spontaneous hematomas (HP:0007420)3.88346479
19Meningitis (HP:0001287)3.58404314
20Vacuolated lymphocytes (HP:0001922)3.55977575
21Chronic mucocutaneous candidiasis (HP:0002728)3.50613277
22Recurrent cutaneous fungal infections (HP:0011370)3.50613277
23Recurrent viral infections (HP:0004429)3.46948504
24Pustule (HP:0200039)3.38559835
25Periodontitis (HP:0000704)3.36561474
26Keratoconjunctivitis sicca (HP:0001097)3.36420991
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.25350934
28Vasculitis (HP:0002633)3.22981198
29Joint hemorrhage (HP:0005261)3.15271383
30Thick nail (HP:0001805)3.13936951
31Petechiae (HP:0000967)3.10671528
32Abnormality of glycolipid metabolism (HP:0010969)3.06308358
33Abnormality of liposaccharide metabolism (HP:0010968)3.06308358
34Abnormality of glycosphingolipid metabolism (HP:0004343)3.06308358
35Keratoconjunctivitis (HP:0001096)3.05321670
36Pulmonary infiltrates (HP:0002113)3.01258819
37Agnosia (HP:0010524)2.95555915
38Hemoptysis (HP:0002105)2.95337257
39Prostate neoplasm (HP:0100787)2.89172252
40IgM deficiency (HP:0002850)2.85682684
41Cellulitis (HP:0100658)2.84432455
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.83742713
43Increased cerebral lipofuscin (HP:0011813)2.83304566
44Arterial thrombosis (HP:0004420)2.82508151
45Disinhibition (HP:0000734)2.80520601
46Glomerulonephritis (HP:0000099)2.80437501
47Hypochromic anemia (HP:0001931)2.79802914
48Stomatitis (HP:0010280)2.78946854
49Episodic fever (HP:0001954)2.73240603
50Leukocytosis (HP:0001974)2.73117504
51Encephalitis (HP:0002383)2.71215378
52Amyloidosis (HP:0011034)2.70586330
53Hypochromic microcytic anemia (HP:0004840)2.70296814
54Abnormality of the prostate (HP:0008775)2.70115618
55Axonal loss (HP:0003447)2.68225929
56Increased IgM level (HP:0003496)2.64984321
57Peritonitis (HP:0002586)2.62667018
58Thrombocytosis (HP:0001894)2.58911707
59Recurrent pneumonia (HP:0006532)2.58202055
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50477927
61Urticaria (HP:0001025)2.50383951
62Basal ganglia calcification (HP:0002135)2.47185433
63IgG deficiency (HP:0004315)2.46163267
64Abnormality of T cell physiology (HP:0011840)2.45581966
65Chronic otitis media (HP:0000389)2.44866661
66Abnormality of T cells (HP:0002843)2.44304026
67Autoimmune thrombocytopenia (HP:0001973)2.43538158
68Agammaglobulinemia (HP:0004432)2.42786340
69Gastrointestinal infarctions (HP:0005244)2.41500972
70Osteomyelitis (HP:0002754)2.41134811
71Epistaxis (HP:0000421)2.40779578
72Gingival bleeding (HP:0000225)2.40171667
73Eosinophilia (HP:0001880)2.40035919
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.38648788
75Prolonged bleeding time (HP:0003010)2.34214416
76Hypergammaglobulinemia (HP:0010702)2.32798863
77Inflammation of the large intestine (HP:0002037)2.32690081
78Abnormality of T cell number (HP:0011839)2.31898872
79T lymphocytopenia (HP:0005403)2.31032108
80Interstitial pulmonary disease (HP:0006530)2.31016969
81Osteolytic defects of the phalanges of the hand (HP:0009771)2.29559032
82Osteolytic defects of the hand bones (HP:0009699)2.29559032
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.28586589
84Chest pain (HP:0100749)2.27804986
85Increased IgE level (HP:0003212)2.25775571
86Cheilitis (HP:0100825)2.21729863
87Gangrene (HP:0100758)2.21559603
88Recurrent lower respiratory tract infections (HP:0002783)2.20493424
89Hematochezia (HP:0002573)2.20094233
90Acute hepatic failure (HP:0006554)2.19884162
91Dysostosis multiplex (HP:0000943)2.17613481
92Panhypogammaglobulinemia (HP:0003139)2.15664593
93Abnormality of the pleura (HP:0002103)2.14089386
94Abnormality of eosinophils (HP:0001879)2.11595267
95Increased serum ferritin (HP:0003281)2.10043430
96Granulocytopenia (HP:0001913)2.09180202
97Gastrointestinal inflammation (HP:0004386)2.08431827
98Abnormality of the endocardium (HP:0004306)2.08245018
99Colitis (HP:0002583)2.07347950
100Pulmonary embolism (HP:0002204)2.06573583
101Joint swelling (HP:0001386)2.05758429
102Microcytic anemia (HP:0001935)2.04680428
103Recurrent bronchitis (HP:0002837)2.03934747
104Abnormality of the peritoneum (HP:0002585)2.03287901
105Glomerulopathy (HP:0100820)2.03141460
106Stomach cancer (HP:0012126)2.02816925
107Autoimmune hemolytic anemia (HP:0001890)2.02506798
108Abnormality of complement system (HP:0005339)2.02286610
109Skin rash (HP:0000988)2.01755666
110Severe combined immunodeficiency (HP:0004430)2.01299144
111Anorexia (HP:0002039)2.00506051
112Skin ulcer (HP:0200042)1.99722245
113Amaurosis fugax (HP:0100576)1.99717551
114Acne (HP:0001061)1.99712886
115Nasal polyposis (HP:0100582)1.99426749
116Vertigo (HP:0002321)1.97459947
117Sepsis (HP:0100806)1.96991355
118Abnormality of iron homeostasis (HP:0011031)1.94977442
119Abnormal platelet volume (HP:0011876)1.94346012
120Purpura (HP:0000979)1.93454857
121Hemiplegia (HP:0002301)1.92936135
122Nephritis (HP:0000123)1.91490853
123Verrucae (HP:0200043)1.89962059
124Papilloma (HP:0012740)1.89962059
125Thyroiditis (HP:0100646)1.89002410
126Lymphopenia (HP:0001888)1.88756194
127Absent frontal sinuses (HP:0002688)1.88479394
128Chronic diarrhea (HP:0002028)1.88461683
129Viral hepatitis (HP:0006562)1.87664972
130Polyneuropathy (HP:0001271)1.87661514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.23736078
2IRAK44.04044803
3MAP3K144.00658453
4TXK3.25724748
5IRAK33.24595271
6RIPK43.19843984
7TYK23.18526372
8MAP4K13.00015943
9KIT2.43196673
10TAOK32.30327084
11PRPF4B2.28123316
12NEK92.27267225
13GRK72.21433896
14JAK32.18363277
15JAK12.15386873
16TEC2.14296497
17TBK12.03465351
18PIM21.97975116
19IKBKE1.96101924
20BTK1.84768079
21ZAP701.84733246
22ITK1.78214387
23STK101.72680306
24CSK1.67875121
25IKBKB1.67048909
26SYK1.56635078
27CLK11.56080474
28MAP3K31.35122792
29CSF1R1.33776927
30LYN1.30726227
31LCK1.30040972
32PIM11.27668670
33HCK1.22335411
34MAP3K131.21705171
35ERN11.21538070
36MAP3K111.20232514
37TGFBR21.17397077
38FES1.16343393
39TAOK11.15518651
40MAP3K11.08502438
41MAP3K121.05810392
42EPHB11.04720157
43KSR21.02830197
44FGFR31.01765586
45ADRBK21.00194895
46NME20.96114425
47BMPR20.93638547
48TRPM70.88772071
49MAP2K30.86799899
50CDK60.84853477
51CHUK0.84644550
52MARK20.84566335
53MAP3K70.84307161
54MST40.82919897
55GRK60.80058465
56MATK0.79272268
57LRRK20.78682082
58MAP2K20.76649519
59* JAK20.76479665
60SIK20.75935238
61EIF2AK20.75627519
62MAPK120.72624848
63SIK30.71225434
64MAPK70.70789259
65MARK30.70513994
66TRIB30.70071348
67TESK20.69932410
68YES10.68980260
69ABL20.68757349
70RPS6KA40.68067219
71PRKCQ0.67736899
72RPS6KA60.67599771
73PDPK10.67584467
74PTK60.66933417
75MAP3K20.64730016
76RPS6KC10.63228622
77RPS6KL10.63228622
78PRKCD0.59750665
79STK40.56514110
80CDK190.55909383
81CAMKK20.55538336
82GRK50.55534057
83MAPKAPK20.55257591
84BMX0.53351371
85MAP3K60.52649983
86FGR0.51573318
87NUAK10.50938838
88ABL10.50538921
89FGFR40.49286869
90IRAK20.49157038
91RET0.47911133
92MAP3K100.46628649
93PIK3CG0.45953564
94SGK30.45468102
95IRAK10.45440554
96CAMKK10.44768310
97SMG10.44274731
98STK110.43700063
99PTK2B0.43591762
100RPS6KA20.43551546
101TNK20.42909488
102PRKD20.42830728
103HIPK20.42337841
104TAOK20.39869746
105MAP2K40.39640534
106RAF10.37963119
107FYN0.37462309
108DYRK1B0.35753149
109PBK0.35464958
110EGFR0.34253667
111NLK0.33737417
112CDC42BPA0.32343829
113DAPK10.32289944
114MAP3K50.31744101
115SCYL20.31455432
116MAPK40.30643483
117FLT30.30527894
118ERBB30.30223621
119STK240.30047162
120MOS0.29715891
121PDK10.29623316
122MAPK110.29154173
123PAK40.28359328
124RIPK10.28220703
125NEK60.27328425
126CDK40.26776409
127ARAF0.26123499
128ZAK0.22482815
129MAP3K80.21618696
130KDR0.20751554
131IGF1R0.18961171
132TTN0.18106087
133FRK0.17967755
134CDK90.16654259
135EPHA30.15622973
136TLK10.15008269
137MAP2K60.13638838

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.66847167
2Leishmaniasis_Homo sapiens_hsa051403.50328462
3Staphylococcus aureus infection_Homo sapiens_hsa051503.24407516
4Osteoclast differentiation_Homo sapiens_hsa043802.58731176
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.56170519
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.55912898
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.34324059
8Pertussis_Homo sapiens_hsa051332.33452331
9Tuberculosis_Homo sapiens_hsa051522.31020220
10Allograft rejection_Homo sapiens_hsa053302.27286161
11Antigen processing and presentation_Homo sapiens_hsa046122.23882133
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.20421613
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19452553
14Measles_Homo sapiens_hsa051622.17451933
15Legionellosis_Homo sapiens_hsa051342.12045669
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10907038
17Primary immunodeficiency_Homo sapiens_hsa053402.06394854
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02982581
19Malaria_Homo sapiens_hsa051441.90107001
20Phagosome_Homo sapiens_hsa041451.89853979
21Other glycan degradation_Homo sapiens_hsa005111.88889041
22Lysosome_Homo sapiens_hsa041421.87246701
23Rheumatoid arthritis_Homo sapiens_hsa053231.73453742
24Salmonella infection_Homo sapiens_hsa051321.72060492
25Toxoplasmosis_Homo sapiens_hsa051451.72014084
26B cell receptor signaling pathway_Homo sapiens_hsa046621.71670002
27Asthma_Homo sapiens_hsa053101.65835422
28Hematopoietic cell lineage_Homo sapiens_hsa046401.63774598
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63250802
30Influenza A_Homo sapiens_hsa051641.53719991
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53566205
32Viral myocarditis_Homo sapiens_hsa054161.52021341
33Apoptosis_Homo sapiens_hsa042101.49075482
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47785433
35Herpes simplex infection_Homo sapiens_hsa051681.46128586
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.44770099
37* Chemokine signaling pathway_Homo sapiens_hsa040621.44199586
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.43226214
39Autoimmune thyroid disease_Homo sapiens_hsa053201.38917388
40Shigellosis_Homo sapiens_hsa051311.37987357
41* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36688042
42Type I diabetes mellitus_Homo sapiens_hsa049401.31506674
43T cell receptor signaling pathway_Homo sapiens_hsa046601.27521158
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.25880591
45TNF signaling pathway_Homo sapiens_hsa046681.23682966
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23375600
47Hepatitis B_Homo sapiens_hsa051611.05492491
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04688994
49Platelet activation_Homo sapiens_hsa046110.97648853
50Complement and coagulation cascades_Homo sapiens_hsa046100.86082707
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83111353
52Hepatitis C_Homo sapiens_hsa051600.81687773
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80424961
54African trypanosomiasis_Homo sapiens_hsa051430.79299353
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78712976
56Renal cell carcinoma_Homo sapiens_hsa052110.77586399
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74909174
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73193123
59Acute myeloid leukemia_Homo sapiens_hsa052210.72921945
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.69034475
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68132750
62Pancreatic cancer_Homo sapiens_hsa052120.67903714
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66450416
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65513793
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61944211
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.61651618
67Renin-angiotensin system_Homo sapiens_hsa046140.60996666
68Epstein-Barr virus infection_Homo sapiens_hsa051690.60658793
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59552790
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59544733
71Endometrial cancer_Homo sapiens_hsa052130.59011564
72FoxO signaling pathway_Homo sapiens_hsa040680.56170090
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.54561774
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54225628
75Choline metabolism in cancer_Homo sapiens_hsa052310.53489877
76mTOR signaling pathway_Homo sapiens_hsa041500.53156542
77Amoebiasis_Homo sapiens_hsa051460.52760637
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52733417
79Inositol phosphate metabolism_Homo sapiens_hsa005620.52616576
80Colorectal cancer_Homo sapiens_hsa052100.52071477
81Dorso-ventral axis formation_Homo sapiens_hsa043200.51444951
82Sphingolipid metabolism_Homo sapiens_hsa006000.51281802
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50301973
84GnRH signaling pathway_Homo sapiens_hsa049120.48630010
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47778520
86Chronic myeloid leukemia_Homo sapiens_hsa052200.45365081
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45219817
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.44118301
89DNA replication_Homo sapiens_hsa030300.42333481
90Endocytosis_Homo sapiens_hsa041440.41830805
91Rap1 signaling pathway_Homo sapiens_hsa040150.41682929
92Viral carcinogenesis_Homo sapiens_hsa052030.41682199
93HTLV-I infection_Homo sapiens_hsa051660.39857288
94Type II diabetes mellitus_Homo sapiens_hsa049300.39757384
95Insulin resistance_Homo sapiens_hsa049310.36732082
96MAPK signaling pathway_Homo sapiens_hsa040100.36485051
97HIF-1 signaling pathway_Homo sapiens_hsa040660.34175634
98ErbB signaling pathway_Homo sapiens_hsa040120.34091748
99Regulation of autophagy_Homo sapiens_hsa041400.33230880
100Glioma_Homo sapiens_hsa052140.32547231
101Prolactin signaling pathway_Homo sapiens_hsa049170.29598917
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28528484
103VEGF signaling pathway_Homo sapiens_hsa043700.28062643
104p53 signaling pathway_Homo sapiens_hsa041150.27527138
105Prion diseases_Homo sapiens_hsa050200.25173480
106Base excision repair_Homo sapiens_hsa034100.24760207
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24446858
108Arachidonic acid metabolism_Homo sapiens_hsa005900.23319144
109Caffeine metabolism_Homo sapiens_hsa002320.23243601
110Non-homologous end-joining_Homo sapiens_hsa034500.21820786
111Homologous recombination_Homo sapiens_hsa034400.21493587
112Small cell lung cancer_Homo sapiens_hsa052220.20485292
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19818073
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19272713
115Notch signaling pathway_Homo sapiens_hsa043300.17760429
116Collecting duct acid secretion_Homo sapiens_hsa049660.15819676
117Non-small cell lung cancer_Homo sapiens_hsa052230.14936137
118Proteoglycans in cancer_Homo sapiens_hsa052050.12946836
119Pentose phosphate pathway_Homo sapiens_hsa000300.08698438
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07633390
121Vibrio cholerae infection_Homo sapiens_hsa051100.06924215
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05575000
123Systemic lupus erythematosus_Homo sapiens_hsa053220.05296470

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