CCR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell apoptotic process (GO:0002902)9.71876630
2negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)8.95444243
3immunoglobulin mediated immune response (GO:0016064)8.79015324
4positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610818.70260137
5positive regulation of lipoprotein lipase activity (GO:0051006)8.56023947
6positive regulation of triglyceride lipase activity (GO:0061365)8.56023947
7regulation of memory T cell differentiation (GO:0043380)8.55617543
8negative regulation of digestive system process (GO:0060457)8.55495622
9regulation of interleukin-8 biosynthetic process (GO:0045414)8.48789604
10regulation of T-helper 2 cell differentiation (GO:0045628)8.34620595
11regulation of cholesterol homeostasis (GO:2000188)8.06962745
12negative regulation of type 2 immune response (GO:0002829)7.85531799
13regulation of ER to Golgi vesicle-mediated transport (GO:0060628)7.72273888
14germinal center formation (GO:0002467)7.48437895
15positive regulation of triglyceride biosynthetic process (GO:0010867)7.45982510
16T cell apoptotic process (GO:0070231)7.11158577
17negative regulation of alpha-beta T cell differentiation (GO:0046639)7.02774853
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.98234177
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.95294754
20negative regulation of cell killing (GO:0031342)6.95294754
21regulation of mitotic spindle organization (GO:0060236)6.81530426
22negative regulation of macrophage derived foam cell differentiation (GO:0010745)6.71075358
23regulation of cholesterol storage (GO:0010885)6.67220154
24B cell mediated immunity (GO:0019724)6.50673741
25positive regulation of receptor biosynthetic process (GO:0010870)6.40736057
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.37798448
27positive regulation by organism of defense response of other organism involved in symbiotic interact6.37798448
28modulation by symbiont of host immune response (GO:0052553)6.37798448
29positive regulation by symbiont of host defense response (GO:0052509)6.37798448
30modulation by symbiont of host defense response (GO:0052031)6.37798448
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.37798448
32response to food (GO:0032094)6.33348449
33positive regulation of fatty acid biosynthetic process (GO:0045723)6.31808676
34regulation of germinal center formation (GO:0002634)6.21065075
35lymphocyte apoptotic process (GO:0070227)6.19083405
36positive regulation of cholesterol efflux (GO:0010875)6.00425228
37apoptotic cell clearance (GO:0043277)6.00406930
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.88220539
39positive regulation of toll-like receptor signaling pathway (GO:0034123)5.86867544
40positive regulation of gamma-delta T cell activation (GO:0046645)5.85593693
41negative regulation of lymphocyte apoptotic process (GO:0070229)5.84162592
42regulation of toll-like receptor 4 signaling pathway (GO:0034143)5.80383725
43NLS-bearing protein import into nucleus (GO:0006607)5.77008813
44antigen processing and presentation of endogenous antigen (GO:0019883)5.61999506
45negative regulation of Rho protein signal transduction (GO:0035024)5.49821827
46neutrophil activation involved in immune response (GO:0002283)5.37686812
47positive regulation of sterol transport (GO:0032373)5.34211969
48positive regulation of cholesterol transport (GO:0032376)5.34211969
49regulation of B cell receptor signaling pathway (GO:0050855)5.30795464
50negative regulation of cytokine production involved in immune response (GO:0002719)5.28124723
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.23127461
52detection of other organism (GO:0098543)5.22957200
53regulation of triglyceride biosynthetic process (GO:0010866)5.22035048
54macrophage activation involved in immune response (GO:0002281)5.20780051
55negative regulation of lipid storage (GO:0010888)5.19839748
56detection of molecule of bacterial origin (GO:0032490)5.16195070
57cytokine biosynthetic process (GO:0042089)4.98212314
58positive regulation of triglyceride metabolic process (GO:0090208)4.97784087
59detection of bacterium (GO:0016045)4.84957585
60detection of external biotic stimulus (GO:0098581)4.78813871
61response to interleukin-15 (GO:0070672)4.74166587
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.71355608
63cellular extravasation (GO:0045123)4.71306225
64negative regulation of alpha-beta T cell activation (GO:0046636)4.66116345
65leukocyte apoptotic process (GO:0071887)4.60081048
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.58314202
67regulation of interferon-beta biosynthetic process (GO:0045357)4.57737853
68neutrophil activation (GO:0042119)4.57203725
69auditory behavior (GO:0031223)4.55724736
70C4-dicarboxylate transport (GO:0015740)4.55621693
71response to peptidoglycan (GO:0032494)4.55144890
72cellular response to interleukin-15 (GO:0071350)4.49502673
73regulation of spindle organization (GO:0090224)4.42796134
74dicarboxylic acid biosynthetic process (GO:0043650)4.40185457
75L-amino acid import (GO:0043092)4.38697901
76respiratory burst (GO:0045730)4.36883564
77apoptotic DNA fragmentation (GO:0006309)4.34594775
78negative regulation of leukocyte apoptotic process (GO:2000107)4.34502990
79leukocyte aggregation (GO:0070486)4.31851069
80negative regulation of interleukin-12 production (GO:0032695)4.29951559
81microglial cell activation (GO:0001774)4.29921043
82negative regulation of production of molecular mediator of immune response (GO:0002701)4.28969003
83response to host immune response (GO:0052572)4.28567025
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.28567025
85neutrophil mediated immunity (GO:0002446)4.26301474
86regulation of gamma-delta T cell activation (GO:0046643)4.26233105
87negative regulation of lymphocyte mediated immunity (GO:0002707)4.21102144
88negative regulation of innate immune response (GO:0045824)4.20571148
89regulation of T cell receptor signaling pathway (GO:0050856)4.18026642
90regulation of cholesterol efflux (GO:0010874)4.17698422
91response to fungus (GO:0009620)4.16262648
92detection of biotic stimulus (GO:0009595)4.12799303
93leukocyte migration involved in inflammatory response (GO:0002523)4.11002794
94proteasome assembly (GO:0043248)4.10140678
95granulocyte activation (GO:0036230)4.06035984
96cytokine metabolic process (GO:0042107)4.02229416
97macrophage activation (GO:0042116)3.96875259
98response to host (GO:0075136)3.95102833
99response to host defenses (GO:0052200)3.95102833
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95102833
101regulation of cytokine production involved in immune response (GO:0002718)3.92661830
102erythrocyte development (GO:0048821)3.90855745
103regulation of gamma-delta T cell differentiation (GO:0045586)3.88465482
104negative regulation of T cell mediated immunity (GO:0002710)3.83953789
105ADP metabolic process (GO:0046031)3.83122779
106negative regulation of DNA recombination (GO:0045910)3.78119638
107positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.78038342
108myeloid cell activation involved in immune response (GO:0002275)3.77294685
109nucleoside diphosphate biosynthetic process (GO:0009133)3.76991587
110regulation of mast cell degranulation (GO:0043304)3.67044283
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.64978570
112production of molecular mediator involved in inflammatory response (GO:0002532)3.63032456
113positive regulation of interleukin-8 production (GO:0032757)3.62493005
114positive regulation of cytokine production involved in immune response (GO:0002720)3.60095038
115regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.57700555
116myeloid leukocyte mediated immunity (GO:0002444)3.56463462
117antigen processing and presentation via MHC class Ib (GO:0002475)3.55285168
118regulation of macrophage derived foam cell differentiation (GO:0010743)3.52531618
119B cell receptor signaling pathway (GO:0050853)3.51698208
120glutamine family amino acid biosynthetic process (GO:0009084)3.51504176
121regulation of lymphocyte apoptotic process (GO:0070228)3.51340511
122adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.49317631
123positive regulation of mast cell activation (GO:0033005)3.47872807
124regulation of triglyceride metabolic process (GO:0090207)3.47361588
125triglyceride homeostasis (GO:0070328)3.47216734
126acylglycerol homeostasis (GO:0055090)3.47216734
127regulation of response to interferon-gamma (GO:0060330)3.46903873
128regulation of receptor biosynthetic process (GO:0010869)3.46882936
129protein import into nucleus, translocation (GO:0000060)3.46731806
130regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45246660
131negative regulation of leukocyte mediated immunity (GO:0002704)3.44127536
132regulation of T-helper cell differentiation (GO:0045622)3.40121556
133regulation of mast cell activation involved in immune response (GO:0033006)3.39949238
134regulation of T cell tolerance induction (GO:0002664)3.38158357
135regulation of myeloid leukocyte mediated immunity (GO:0002886)3.35976234
136dendritic cell migration (GO:0036336)3.35867012
137negative regulation of phagocytosis (GO:0050765)3.33392822
138negative regulation of lipid transport (GO:0032369)3.32984797
139leukocyte degranulation (GO:0043299)3.32320761
140cellular response to type I interferon (GO:0071357)3.29011617
141type I interferon signaling pathway (GO:0060337)3.29011617
142regulation of tolerance induction (GO:0002643)3.28463974
143regulation of B cell differentiation (GO:0045577)3.27060878
144response to type I interferon (GO:0034340)3.26443905
145dendritic cell chemotaxis (GO:0002407)3.25372750
146endothelium development (GO:0003158)3.24020359
147regulation of type 2 immune response (GO:0002828)3.23733557
148regulation of leukocyte degranulation (GO:0043300)3.21832182
149regulation of mast cell activation (GO:0033003)3.21623078
150negative thymic T cell selection (GO:0045060)3.21229584
151amino acid import (GO:0043090)3.19849665
152response to thyroid hormone (GO:0097066)3.19478229
153negative T cell selection (GO:0043383)3.18116539
154positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16659232
155regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.16461922
156regulation of macrophage activation (GO:0043030)3.15357510
157regulation of T cell mediated cytotoxicity (GO:0001914)3.15119380
158mechanosensory behavior (GO:0007638)3.14851257
159negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13974657
160regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12645018
161defense response to protozoan (GO:0042832)3.09637513
162cell morphogenesis involved in neuron differentiation (GO:0048667)3.08953864
163AMP metabolic process (GO:0046033)3.07082613
164response to muramyl dipeptide (GO:0032495)3.02035627
165neurotransmitter uptake (GO:0001504)3.01246341
166positive regulation of fatty acid metabolic process (GO:0045923)3.00519048
167regulation of natural killer cell mediated immunity (GO:0002715)3.00209825
168regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.00209825
169regulation of alpha-beta T cell proliferation (GO:0046640)2.99454440
170tolerance induction (GO:0002507)2.99362470
171regulation of regulatory T cell differentiation (GO:0045589)2.99296960
172regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98131314
173negative regulation of interleukin-6 production (GO:0032715)2.96446336
174positive regulation of B cell differentiation (GO:0045579)2.95321041
175lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92944506
176regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92906357
177activated T cell proliferation (GO:0050798)2.92634063
178regulation of regulated secretory pathway (GO:1903305)2.90915878
179myeloid leukocyte activation (GO:0002274)2.90540675
180positive thymic T cell selection (GO:0045059)2.90135462
181purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.89872598
182regulation of isotype switching (GO:0045191)2.88582458
183regulation of digestive system process (GO:0044058)2.79641151
184negative regulation of B cell apoptotic process (GO:0002903)15.0922802
185positive regulation of interleukin-8 biosynthetic process (GO:0045416)12.7272106
186negative regulation of immunoglobulin mediated immune response (GO:0002890)10.3805068
187negative regulation of B cell mediated immunity (GO:0002713)10.3805068
188negative regulation of T-helper cell differentiation (GO:0045623)10.3538816
189negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)10.3538816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.32090659
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.18112578
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49401298
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.18410027
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14139908
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.38394606
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.76829427
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76661775
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.72067605
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69042212
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.57882152
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.57555243
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55534078
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52402557
15NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.51416155
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43905668
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35890952
18RUNX1_22412390_ChIP-Seq_EML_Mouse2.29634306
19RUNX_20019798_ChIP-Seq_JUKART_Human2.28121774
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28012371
21EZH2_22144423_ChIP-Seq_EOC_Human2.26665993
22VDR_24787735_ChIP-Seq_THP-1_Human2.15912722
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.14373379
24GATA1_22025678_ChIP-Seq_K562_Human2.13490774
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12031766
26MAF_26560356_Chip-Seq_TH1_Human2.08159029
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07795852
28LXR_22158963_ChIP-Seq_LIVER_Mouse2.06255206
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04897090
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.04803760
31ESR1_15608294_ChIP-ChIP_MCF-7_Human2.01914444
32VDR_24763502_ChIP-Seq_THP-1_Human2.00042935
33CLOCK_20551151_ChIP-Seq_293T_Human1.96371928
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96067985
35MYB_26560356_Chip-Seq_TH2_Human1.92153851
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.91356946
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88438914
38E2F7_22180533_ChIP-Seq_HELA_Human1.86516363
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74780994
40TP53_16413492_ChIP-PET_HCT116_Human1.68499518
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68084548
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.65063158
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63868842
44KDM2B_26808549_Chip-Seq_DND41_Human1.61254795
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61141976
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59580246
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.58444826
48MYC_22102868_ChIP-Seq_BL_Human1.56719190
49* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56639514
50VDR_21846776_ChIP-Seq_THP-1_Human1.54609761
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54387542
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53956407
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53290598
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52532793
55SPI1_23127762_ChIP-Seq_K562_Human1.51041812
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44974588
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.43221641
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42918197
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41914971
60MYB_26560356_Chip-Seq_TH1_Human1.41082801
61PU_27001747_Chip-Seq_BMDM_Mouse1.36019541
62* GATA3_26560356_Chip-Seq_TH2_Human1.35488905
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35445376
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.35092308
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34573532
66GATA2_19941826_ChIP-Seq_K562_Human1.34200668
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32589650
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30637435
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29093083
70* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28507064
71* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24820326
72* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23512356
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22912952
74SCL_19346495_ChIP-Seq_HPC-7_Human1.22392374
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21860250
76* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21349901
77* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21137172
78* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20281081
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19810047
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16840086
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.16128663
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15853391
83GATA1_19941826_ChIP-Seq_K562_Human1.14854256
84* GATA1_19941827_ChIP-Seq_MEL_Mouse1.14305069
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14056818
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13976262
87GATA3_27048872_Chip-Seq_THYMUS_Human1.12963045
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.12798243
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11372603
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10960798
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.10546717
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09736050
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09700035
94* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09556990
95TCF7_22412390_ChIP-Seq_EML_Mouse1.08555660
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08496270
97SPI1_23547873_ChIP-Seq_NB4_Human1.07736939
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07434282
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07118599
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06751143
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05816912
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04913974
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03422689
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01460591
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00540132
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99165491
107CJUN_26792858_Chip-Seq_BT549_Human0.96787642
108BCL6_27268052_Chip-Seq_Bcells_Human0.96140042
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95789972
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95166836
111UTX_26944678_Chip-Seq_JUKART_Human0.94609646
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94529292
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94347004
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94347004
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93293781
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93104193
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93099727
118MAF_26560356_Chip-Seq_TH2_Human0.90767305
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90607677
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88920610
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88606864
122BCOR_27268052_Chip-Seq_Bcells_Human0.88010080
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86897860
124* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86199635
125NCOR1_26117541_ChIP-Seq_K562_Human0.85749910
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84125961
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84125961
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.83119880
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81740763
130LXR_22292898_ChIP-Seq_THP-1_Human0.80631847
131* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80617535
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79493775
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79159727
134SMRT_27268052_Chip-Seq_Bcells_Human0.78921470
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77519080
136SPI1_20517297_ChIP-Seq_HL60_Human0.76510190
137RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75366904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol8.76079427
2MP0003329_amyloid_beta_deposits4.99404627
3MP0005365_abnormal_bile_salt4.26447115
4MP0000604_amyloidosis3.69584732
5MP0001853_heart_inflammation3.36081859
6MP0000685_abnormal_immune_system2.78498727
7MP0002132_abnormal_respiratory_system2.31201068
8MP0004145_abnormal_muscle_electrophysio2.13085730
9MP0002139_abnormal_hepatobiliary_system13.5815862
10MP0005647_abnormal_sex_gland1.99931338
11MP0003183_abnormal_peptide_metabolism1.97863251
12MP0004381_abnormal_hair_follicle1.97740541
13MP0002277_abnormal_respiratory_mucosa1.94063201
14MP0003828_pulmonary_edema1.87033480
15MP0003303_peritoneal_inflammation1.79784176
16MP0003806_abnormal_nucleotide_metabolis1.76731533
17MP0005451_abnormal_body_composition1.71048838
18MP0004270_analgesia1.59555142
19MP0004883_abnormal_blood_vessel1.57985230
20MP0010329_abnormal_lipoprotein_level1.52955999
21MP0001790_abnormal_immune_system1.50438556
22MP0005387_immune_system_phenotype1.50438556
23MP0001800_abnormal_humoral_immune1.41310803
24MP0003632_abnormal_nervous_system1.36097910
25MP0005025_abnormal_response_to1.32874126
26MP0005310_abnormal_salivary_gland1.32670006
27MP0000858_altered_metastatic_potential1.29339261
28MP0005164_abnormal_response_to1.24691014
29MP0000465_gastrointestinal_hemorrhage1.22249581
30MP0005360_urolithiasis1.21930244
31MP0009333_abnormal_splenocyte_physiolog1.19238881
32MP0005319_abnormal_enzyme/_coenzyme1.18676494
33MP0002452_abnormal_antigen_presenting1.11342893
34MP0003436_decreased_susceptibility_to1.10732203
35MP0002998_abnormal_bone_remodeling1.07630261
36MP0000609_abnormal_liver_physiology1.07574135
37MP0005075_abnormal_melanosome_morpholog1.05246277
38MP0001835_abnormal_antigen_presentation1.05241833
39MP0005058_abnormal_lysosome_morphology1.03989543
40* MP0008469_abnormal_protein_level1.02974128
41MP0002419_abnormal_innate_immunity0.99175896
42MP0004510_myositis0.98759401
43MP0002405_respiratory_system_inflammati0.98502502
44MP0003880_abnormal_central_pattern0.95231579
45MP0003724_increased_susceptibility_to0.95189517
46MP0009379_abnormal_foot_pigmentation0.94399713
47MP0001845_abnormal_inflammatory_respons0.93261871
48MP0002166_altered_tumor_susceptibility0.93130180
49MP0008004_abnormal_stomach_pH0.92540128
50MP0005671_abnormal_response_to0.92456540
51MP0003631_nervous_system_phenotype0.92019631
52MP0009785_altered_susceptibility_to0.91347648
53MP0000689_abnormal_spleen_morphology0.91307688
54MP0005000_abnormal_immune_tolerance0.91201638
55* MP0002723_abnormal_immune_serum0.91137418
56MP0009840_abnormal_foam_cell0.89307466
57MP0003656_abnormal_erythrocyte_physiolo0.88972132
58MP0005464_abnormal_platelet_physiology0.86723632
59* MP0002420_abnormal_adaptive_immunity0.85386674
60MP0004130_abnormal_muscle_cell0.84799767
61MP0003045_fibrosis0.84723332
62* MP0001819_abnormal_immune_cell0.84522894
63MP0005390_skeleton_phenotype0.84155756
64MP0003448_altered_tumor_morphology0.82487727
65MP0003221_abnormal_cardiomyocyte_apopto0.80741958
66MP0000569_abnormal_digit_pigmentation0.80695610
67MP0001986_abnormal_taste_sensitivity0.80070928
68MP0001663_abnormal_digestive_system0.79726583
69MP0000490_abnormal_crypts_of0.79378590
70MP0000747_muscle_weakness0.78894454
71MP0008260_abnormal_autophagy0.76370320
72MP0005409_darkened_coat_color0.74151533
73* MP0002398_abnormal_bone_marrow0.72797127
74MP0003300_gastrointestinal_ulcer0.72555202
75MP0002332_abnormal_exercise_endurance0.69429099
76MP0003075_altered_response_to0.68676973
77MP0009763_increased_sensitivity_to0.68225314
78MP0002928_abnormal_bile_duct0.67687357
79MP0001873_stomach_inflammation0.67359351
80MP0008874_decreased_physiological_sensi0.67047423
81MP0003633_abnormal_nervous_system0.66458826
82MP0000249_abnormal_blood_vessel0.66180918
83MP0005377_hearing/vestibular/ear_phenot0.65666030
84MP0003878_abnormal_ear_physiology0.65666030
85MP0009765_abnormal_xenobiotic_induced0.65362200
86MP0003252_abnormal_bile_duct0.65274172
87MP0008875_abnormal_xenobiotic_pharmacok0.64995396
88MP0002396_abnormal_hematopoietic_system0.64410948
89MP0000920_abnormal_myelination0.62948887
90MP0002148_abnormal_hypersensitivity_rea0.61681879
91MP0005332_abnormal_amino_acid0.61133999
92MP0005174_abnormal_tail_pigmentation0.60851885
93MP0002138_abnormal_hepatobiliary_system0.60098677
94MP0005085_abnormal_gallbladder_physiolo0.58685652
95MP0004808_abnormal_hematopoietic_stem0.58375809
96MP0000703_abnormal_thymus_morphology0.57800442
97MP0003795_abnormal_bone_structure0.57442167
98* MP0000716_abnormal_immune_system0.55260457
99MP0002006_tumorigenesis0.54582636
100MP0004484_altered_response_of0.53622986
101MP0004858_abnormal_nervous_system0.52810583
102MP0005376_homeostasis/metabolism_phenot0.52726359
103MP0005248_abnormal_Harderian_gland0.52586479
104MP0003646_muscle_fatigue0.52314823
105MP0001533_abnormal_skeleton_physiology0.51838698
106MP0002722_abnormal_immune_system0.51341726
107MP0002118_abnormal_lipid_homeostasis0.50536709
108* MP0002429_abnormal_blood_cell0.49589757
109MP0000343_altered_response_to0.47351529
110MP0000598_abnormal_liver_morphology0.46541287
111MP0005167_abnormal_blood-brain_barrier0.46204998
112MP0003186_abnormal_redox_activity0.44813809
113MP0005636_abnormal_mineral_homeostasis0.41448958
114MP0001851_eye_inflammation0.41406932
115MP0010155_abnormal_intestine_physiology0.40607196
116MP0008873_increased_physiological_sensi0.40470042
117MP0004947_skin_inflammation0.39397788
118MP0002876_abnormal_thyroid_physiology0.39137065
119MP0006082_CNS_inflammation0.37470168
120MP0003763_abnormal_thymus_physiology0.36261929
121MP0009764_decreased_sensitivity_to0.34462805
122MP0003690_abnormal_glial_cell0.33929725
123MP0002933_joint_inflammation0.33921114
124* MP0009642_abnormal_blood_homeostasis0.33752990
125MP0000015_abnormal_ear_pigmentation0.33351177
126MP0010630_abnormal_cardiac_muscle0.32844234
127MP0005083_abnormal_biliary_tract0.32842320
128MP0003866_abnormal_defecation0.30548182
129MP0005397_hematopoietic_system_phenotyp0.30499038
130MP0001545_abnormal_hematopoietic_system0.30499038
131MP0001915_intracranial_hemorrhage0.30125835
132MP0005166_decreased_susceptibility_to0.29677761
133MP0010030_abnormal_orbit_morphology0.29336965
134MP0006054_spinal_hemorrhage0.29306190
135MP0003172_abnormal_lysosome_physiology0.27855340
136MP0003635_abnormal_synaptic_transmissio0.27644641
137MP0003566_abnormal_cell_adhesion0.25753488
138MP0009278_abnormal_bone_marrow0.25569806
139MP0005584_abnormal_enzyme/coenzyme_acti0.25466827

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)9.64075040
2Amniotic constriction ring (HP:0009775)7.81008061
3Abnormality of placental membranes (HP:0011409)7.81008061
4Mediastinal lymphadenopathy (HP:0100721)6.87093945
5Abnormality of the peritoneum (HP:0002585)6.32986902
6Myositis (HP:0100614)6.29099161
7Hemiplegia (HP:0002301)6.13744996
8Orchitis (HP:0100796)6.05857369
9Optic neuritis (HP:0100653)5.65254837
10Retrobulbar optic neuritis (HP:0100654)5.65254837
11Nonprogressive disorder (HP:0003680)5.37605643
12Severe combined immunodeficiency (HP:0004430)5.11556458
13Synostosis involving the elbow (HP:0003938)4.95477040
14Humeroradial synostosis (HP:0003041)4.95477040
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.92684225
16Type 2 muscle fiber atrophy (HP:0003554)4.92231545
17Elevated erythrocyte sedimentation rate (HP:0003565)4.76250977
18Hypochromic microcytic anemia (HP:0004840)4.74040699
19Gastrointestinal infarctions (HP:0005244)4.61838679
20Microglossia (HP:0000171)4.57840759
21Combined immunodeficiency (HP:0005387)4.54643053
22Muscle fiber atrophy (HP:0100295)4.45429745
23Hemiparesis (HP:0001269)4.29038706
24Recurrent fungal infections (HP:0002841)4.28733337
25Keratoconjunctivitis sicca (HP:0001097)4.18649589
26Glomerulonephritis (HP:0000099)4.16266007
27Recurrent gram-negative bacterial infections (HP:0005420)4.15975600
28Spontaneous hematomas (HP:0007420)4.09990342
29Systemic lupus erythematosus (HP:0002725)4.05783574
30Recurrent skin infections (HP:0001581)4.01117095
31Encephalitis (HP:0002383)3.95061492
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.94802453
33Keratoconjunctivitis (HP:0001096)3.88241178
34Hypochromic anemia (HP:0001931)3.75137089
35Abnormality of the neuromuscular junction (HP:0003398)3.65383134
36Fatigable weakness (HP:0003473)3.65383134
37Weak cry (HP:0001612)3.64188093
38Renal cell carcinoma (HP:0005584)3.61545905
39Increased IgE level (HP:0003212)3.60464520
40Abnormality of T cell physiology (HP:0011840)3.56985686
41Complement deficiency (HP:0004431)3.54735743
42Vasculitis (HP:0002633)3.51862973
43Anteriorly placed anus (HP:0001545)3.50031411
44Chest pain (HP:0100749)3.49672819
45T lymphocytopenia (HP:0005403)3.44349118
46Chronic mucocutaneous candidiasis (HP:0002728)3.44298799
47Recurrent cutaneous fungal infections (HP:0011370)3.44298799
48Meningitis (HP:0001287)3.41322987
49Peritonitis (HP:0002586)3.41245367
50Recurrent abscess formation (HP:0002722)3.40255142
51Broad ribs (HP:0000885)3.35636509
52Episodic fever (HP:0001954)3.30302586
53Abnormality of T cell number (HP:0011839)3.28470251
54Prolonged bleeding time (HP:0003010)3.28291425
55Abnormality of the pleura (HP:0002103)3.22542958
56Gingival bleeding (HP:0000225)3.21772798
57Easy fatigability (HP:0003388)3.15854017
58Abnormality of the common coagulation pathway (HP:0010990)3.13971471
59Joint swelling (HP:0001386)3.10453549
60Truncal ataxia (HP:0002078)3.08663021
61Granulocytopenia (HP:0001913)3.08179333
62Nasolacrimal duct obstruction (HP:0000579)3.06085000
63Hemoptysis (HP:0002105)3.04105227
64Relative macrocephaly (HP:0004482)3.02701722
65Arterial thrombosis (HP:0004420)3.02410838
66Congenital ichthyosiform erythroderma (HP:0007431)3.02275884
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.96927835
68Anorexia (HP:0002039)2.92569185
69Pulmonary infiltrates (HP:0002113)2.88819021
70Leukocytosis (HP:0001974)2.88293343
71Abnormality of complement system (HP:0005339)2.83589370
72Abnormality of iron homeostasis (HP:0011031)2.81899551
73Pulmonary embolism (HP:0002204)2.80375945
74Decreased muscle mass (HP:0003199)2.78214574
75Choanal stenosis (HP:0000452)2.77207562
76Eczematoid dermatitis (HP:0000976)2.76341064
77Inflammation of the large intestine (HP:0002037)2.74359993
78Lymphedema (HP:0001004)2.71836599
79Abnormalities of placenta or umbilical cord (HP:0001194)2.68989480
80Knee flexion contracture (HP:0006380)2.67444799
81Gastrointestinal inflammation (HP:0004386)2.64968009
82Recurrent bacterial skin infections (HP:0005406)2.63914508
83Pustule (HP:0200039)2.62361155
84Sporadic (HP:0003745)2.60952046
85Osteomyelitis (HP:0002754)2.58094254
86Abnormality of transition element cation homeostasis (HP:0011030)2.51907795
87Increased IgM level (HP:0003496)2.50850301
88Recurrent viral infections (HP:0004429)2.47581148
89Nephritis (HP:0000123)2.42571850
90Type I transferrin isoform profile (HP:0003642)2.40611828
91Gangrene (HP:0100758)2.40240202
92Increased cerebral lipofuscin (HP:0011813)2.40052797
93Stomatitis (HP:0010280)2.38717824
94Reduced antithrombin III activity (HP:0001976)2.37352546
95Symphalangism affecting the phalanges of the hand (HP:0009773)2.35388809
96Petechiae (HP:0000967)2.33098792
97Slow saccadic eye movements (HP:0000514)2.31317698
98Panhypogammaglobulinemia (HP:0003139)2.28543522
99Abnormality of T cells (HP:0002843)2.28474580
100Subacute progressive viral hepatitis (HP:0006572)2.26418492
101Abnormality of the intrinsic pathway (HP:0010989)2.25978683
102Toxemia of pregnancy (HP:0100603)2.24353388
103Increased neuronal autofluorescent lipopigment (HP:0002074)2.23753320
104Lymphopenia (HP:0001888)2.23055767
105Abnormality of the endocardium (HP:0004306)2.22098799
106Abnormality of the lacrimal duct (HP:0011481)2.20050256
107Glomerulopathy (HP:0100820)2.18343205
108Menorrhagia (HP:0000132)2.13514701
109Action tremor (HP:0002345)2.12798235
110Keratitis (HP:0000491)2.12445691
111Acne (HP:0001061)2.11824103
112Azoospermia (HP:0000027)2.11235889
113Eosinophilia (HP:0001880)2.10493028
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.09943235
115Hypergammaglobulinemia (HP:0010702)2.08988030
116Vertigo (HP:0002321)2.07363117
117Abnormal platelet volume (HP:0011876)2.06782940
118Focal motor seizures (HP:0011153)2.05456238
119Acute hepatic failure (HP:0006554)2.05430337
120Hyperglycinuria (HP:0003108)2.05112707
121Deep venous thrombosis (HP:0002625)2.05108564
122Abnormality of the pericardium (HP:0001697)2.04626423
123Skin ulcer (HP:0200042)2.04427142
124Viral hepatitis (HP:0006562)2.02011622
125Skin rash (HP:0000988)1.98464050
126Loss of speech (HP:0002371)1.97837871
127Chronic otitis media (HP:0000389)1.96458410
128Abnormality of the heme biosynthetic pathway (HP:0010472)1.94635585
129Amyloidosis (HP:0011034)1.93991408
130Sepsis (HP:0100806)1.93961513
131IgM deficiency (HP:0002850)1.91873059
132Recurrent pneumonia (HP:0006532)1.90932309
133Elbow flexion contracture (HP:0002987)1.90846189
134Flared metaphyses (HP:0003015)1.90398363
135Gingivitis (HP:0000230)1.89802007
136Recurrent bronchitis (HP:0002837)1.89654341
137Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89521464
138Polycythemia (HP:0001901)1.89000682
139Thoracic kyphosis (HP:0002942)1.88638413
140Premature loss of primary teeth (HP:0006323)1.88008170
141Aplasia/Hypoplasia of the thymus (HP:0010515)1.86975857
142Cellulitis (HP:0100658)1.85924078
143Vacuolated lymphocytes (HP:0001922)1.85457957
144Abnormality of fatty-acid metabolism (HP:0004359)1.83447979
145Papilledema (HP:0001085)1.83226018
146Colitis (HP:0002583)1.82976572
147Polyneuropathy (HP:0001271)1.81916142
148Epistaxis (HP:0000421)1.81522387
149Abnormality of the nasolacrimal system (HP:0000614)1.80955180
150Hypokinesia (HP:0002375)1.80723833
151Hypermelanotic macule (HP:0001034)1.80699760
152Abnormality of macrophages (HP:0004311)1.80357027
153Abnormality of eosinophils (HP:0001879)1.80176556
154Hepatosplenomegaly (HP:0001433)1.79369174
155Cheilitis (HP:0100825)1.78662140
156Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78361220
157Thrombophlebitis (HP:0004418)1.77362727
158Difficulty running (HP:0009046)1.77132228
159Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76813433
160Purpura (HP:0000979)1.76321640
161Chronic obstructive pulmonary disease (HP:0006510)1.74736150
162Obstructive lung disease (HP:0006536)1.74736150
163Apathy (HP:0000741)1.74513514
164Craniofacial hyperostosis (HP:0004493)1.73869589
165Intellectual disability, moderate (HP:0002342)1.71307000
166Abnormality of the thymus (HP:0000777)1.68013238
167Urticaria (HP:0001025)1.67036507
168Gowers sign (HP:0003391)1.65884808
169Xanthomatosis (HP:0000991)1.62906120
170Abnormality of the humeroradial joint (HP:0100744)1.60739616
171Abnormal cortical bone morphology (HP:0003103)1.58894989
172Cellular immunodeficiency (HP:0005374)1.57760258
173Microcytic anemia (HP:0001935)1.56507162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IKBKB3.46171007
2MST42.56342748
3TNK22.41677323
4MUSK14.1661233
5ZAP701.99799508
6PTK61.92450285
7TXK1.86787942
8PRPF4B1.82572295
9MAP4K11.77439473
10CAMKK21.65841398
11PKN21.59368082
12IRAK41.56977408
13MKNK21.54968327
14MAP3K131.52321829
15YES11.47255912
16SIK31.30121383
17KIT1.23095826
18IRAK11.15363384
19CAMKK11.13350557
20CDK191.12492113
21ROCK11.11814227
22MARK31.10759696
23TYK21.09194504
24IRAK21.06369857
25MARK21.06288792
26JAK30.96716162
27MAP3K120.92647400
28TNIK0.91947412
29CSF1R0.89515270
30FES0.84772553
31MKNK10.83450524
32PRKCH0.82954680
33CSNK1G10.82513039
34RAF10.81325471
35GRK60.81269995
36TBK10.79415365
37MAP3K110.79313730
38FLT30.78976463
39PTK2B0.78246897
40MAP2K30.77336388
41BMPR20.77303919
42PDPK10.76416489
43DYRK1B0.75475810
44SIK20.75379570
45TESK20.73374041
46KSR10.72678120
47FGFR30.72258748
48PRKG20.71289603
49MAP3K140.70143733
50SMG10.70061797
51MAP3K10.69596244
52STK110.68748797
53RIPK40.67904800
54TGFBR20.67223838
55STK100.66519009
56JAK20.66136788
57CSK0.64768245
58MAP3K60.64697904
59CSNK1D0.63417061
60TAOK10.63171133
61SGK30.61372956
62SYK0.61343961
63PRKD20.60591309
64CAMK40.59723895
65MAP3K50.58147528
66JAK10.58017156
67RIPK10.56137922
68PIM10.55729316
69CSNK1G30.55602513
70KSR20.54918267
71FGFR40.54600254
72CSNK1A1L0.54356834
73TTN0.52189501
74EPHA30.52161383
75DAPK20.52098445
76LRRK20.51282643
77ERN10.50696554
78MAP3K70.49082611
79SGK10.48927930
80RET0.48658194
81WNK10.48102629
82LCK0.47901995
83PRKG10.47164853
84IRAK30.46366647
85HIPK20.46163229
86BTK0.45622400
87MAP3K100.45457769
88TAOK30.44321515
89SGK20.43873300
90HCK0.43625983
91FYN0.43562713
92FGR0.42813532
93EPHB10.42389724
94MAP2K70.41362310
95MAP3K80.40103032
96PRKCZ0.39486546
97NLK0.39122434
98MAPK70.38488513
99TRIB30.38282532
100MAP3K30.38009968
101IGF1R0.38003298
102MAP3K90.37721509
103LYN0.36765348
104MATK0.36576358
105MAPKAPK20.36253663
106SCYL20.35922215
107STK380.35682684
108SIK10.34571610
109AKT10.34519518
110CDC42BPA0.34338839
111CSNK1G20.34154720
112TEC0.33520371
113MAPK40.33297563
114MAP2K60.33100696
115DYRK30.32129621
116RPS6KC10.31093741
117RPS6KL10.31093741
118ITK0.30246111
119PAK10.27852462
120ABL20.27522454
121RPS6KA60.26946922
122ERBB40.25344633
123AKT20.24960831
124TAOK20.24821891
125CSNK2A10.23301956
126IKBKE0.23269191
127PIK3CG0.21311422
128CAMK10.19448472
129MAPK30.18766947
130CHEK10.18642179
131BLK0.17715119
132CLK10.17541727
133PRKCQ0.16629291
134PRKCD0.15952152
135TLK10.15493370
136KDR0.15480513
137PDK10.15362871
138MAP3K20.15352207
139MAPK120.14086867
140NEK90.13661139
141MAP2K40.13408504

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005335.32800722
2Nitrogen metabolism_Homo sapiens_hsa009105.03051197
3Staphylococcus aureus infection_Homo sapiens_hsa051504.30849515
4B cell receptor signaling pathway_Homo sapiens_hsa046623.89210831
5PPAR signaling pathway_Homo sapiens_hsa033203.11551446
6Base excision repair_Homo sapiens_hsa034102.85906445
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.82911217
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.48569428
9Complement and coagulation cascades_Homo sapiens_hsa046102.37314327
10Arginine biosynthesis_Homo sapiens_hsa002202.23618987
11Graft-versus-host disease_Homo sapiens_hsa053322.14174535
12Allograft rejection_Homo sapiens_hsa053302.03084649
13T cell receptor signaling pathway_Homo sapiens_hsa046602.01131299
14Tuberculosis_Homo sapiens_hsa051521.99038814
15Leishmaniasis_Homo sapiens_hsa051401.94510739
16Autoimmune thyroid disease_Homo sapiens_hsa053201.92707650
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84154845
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.83370119
19ABC transporters_Homo sapiens_hsa020101.64282196
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.51847385
21Non-small cell lung cancer_Homo sapiens_hsa052231.51317778
22N-Glycan biosynthesis_Homo sapiens_hsa005101.50626704
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.47613744
24DNA replication_Homo sapiens_hsa030301.46357336
25Pertussis_Homo sapiens_hsa051331.45371842
26Type I diabetes mellitus_Homo sapiens_hsa049401.45263842
27Insulin resistance_Homo sapiens_hsa049311.43890361
28Influenza A_Homo sapiens_hsa051641.40484205
29Hepatitis C_Homo sapiens_hsa051601.38406541
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30521561
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30492655
32Apoptosis_Homo sapiens_hsa042101.28044412
33Malaria_Homo sapiens_hsa051441.26388578
34Fatty acid degradation_Homo sapiens_hsa000711.25323092
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25224083
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22221788
37beta-Alanine metabolism_Homo sapiens_hsa004101.21640823
38Prion diseases_Homo sapiens_hsa050201.21368072
39Osteoclast differentiation_Homo sapiens_hsa043801.16726337
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11399777
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09868250
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07725002
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07501642
44VEGF signaling pathway_Homo sapiens_hsa043701.07370102
45Chronic myeloid leukemia_Homo sapiens_hsa052201.05566905
46Renal cell carcinoma_Homo sapiens_hsa052111.01767799
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96300427
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94905421
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94629303
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93523680
51Endocytosis_Homo sapiens_hsa041440.91623070
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89705431
53Prolactin signaling pathway_Homo sapiens_hsa049170.89270807
54Endometrial cancer_Homo sapiens_hsa052130.86492336
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84774265
56Dorso-ventral axis formation_Homo sapiens_hsa043200.83736305
57Platelet activation_Homo sapiens_hsa046110.83131753
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.83105981
59* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82065842
60Mineral absorption_Homo sapiens_hsa049780.81698503
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.80179311
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80016268
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77135740
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77135506
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.77027730
66Notch signaling pathway_Homo sapiens_hsa043300.77023921
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76708914
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76616000
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76056162
70Propanoate metabolism_Homo sapiens_hsa006400.73617420
71Choline metabolism in cancer_Homo sapiens_hsa052310.70413729
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69172504
73Legionellosis_Homo sapiens_hsa051340.69049790
74Inositol phosphate metabolism_Homo sapiens_hsa005620.68619127
75Regulation of autophagy_Homo sapiens_hsa041400.67325249
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.67189487
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67153757
78Colorectal cancer_Homo sapiens_hsa052100.66877928
79Amoebiasis_Homo sapiens_hsa051460.66514363
80* Viral carcinogenesis_Homo sapiens_hsa052030.65298556
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65123301
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65052902
83Hematopoietic cell lineage_Homo sapiens_hsa046400.64800853
84mTOR signaling pathway_Homo sapiens_hsa041500.64126088
85Primary immunodeficiency_Homo sapiens_hsa053400.63832847
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63747424
87Fatty acid metabolism_Homo sapiens_hsa012120.63132576
88Epstein-Barr virus infection_Homo sapiens_hsa051690.62853431
89GnRH signaling pathway_Homo sapiens_hsa049120.62065201
90Proteasome_Homo sapiens_hsa030500.61997478
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60822839
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59684995
93HIF-1 signaling pathway_Homo sapiens_hsa040660.58426121
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56962463
95Phagosome_Homo sapiens_hsa041450.55860915
96ErbB signaling pathway_Homo sapiens_hsa040120.55774300
97Other glycan degradation_Homo sapiens_hsa005110.54954451
98Rap1 signaling pathway_Homo sapiens_hsa040150.54368653
99MAPK signaling pathway_Homo sapiens_hsa040100.54108983
100Thyroid cancer_Homo sapiens_hsa052160.53093469
101Asthma_Homo sapiens_hsa053100.53000387
102HTLV-I infection_Homo sapiens_hsa051660.50435591
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.50118074
104FoxO signaling pathway_Homo sapiens_hsa040680.49697132
105Glutamatergic synapse_Homo sapiens_hsa047240.49519114
106Long-term depression_Homo sapiens_hsa047300.47993289
107Shigellosis_Homo sapiens_hsa051310.47121133
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46943634
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45993242
110Acute myeloid leukemia_Homo sapiens_hsa052210.45305557
111Prostate cancer_Homo sapiens_hsa052150.44177132
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.43873068
113Toxoplasmosis_Homo sapiens_hsa051450.42933682
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42924947
115Glioma_Homo sapiens_hsa052140.42838592
116Type II diabetes mellitus_Homo sapiens_hsa049300.42773811
117Bile secretion_Homo sapiens_hsa049760.42212974
118Caffeine metabolism_Homo sapiens_hsa002320.39997245
119Lysosome_Homo sapiens_hsa041420.39229652
120* Chemokine signaling pathway_Homo sapiens_hsa040620.38644541
121Peroxisome_Homo sapiens_hsa041460.38188184
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.38180768
123Measles_Homo sapiens_hsa051620.38160740
124Salmonella infection_Homo sapiens_hsa051320.38099464
125Tryptophan metabolism_Homo sapiens_hsa003800.37231145
126Histidine metabolism_Homo sapiens_hsa003400.36723293
127Pentose phosphate pathway_Homo sapiens_hsa000300.34025743
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32082152
129Starch and sucrose metabolism_Homo sapiens_hsa005000.31764125
130Biosynthesis of amino acids_Homo sapiens_hsa012300.31091560
131Hepatitis B_Homo sapiens_hsa051610.30099543
132Antigen processing and presentation_Homo sapiens_hsa046120.27566519
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.25492578
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24881884
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24651257
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23579074
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23509891
138Folate biosynthesis_Homo sapiens_hsa007900.23447525
139TNF signaling pathway_Homo sapiens_hsa046680.22708264
140Rheumatoid arthritis_Homo sapiens_hsa053230.22142115
141African trypanosomiasis_Homo sapiens_hsa051430.21160997
142Pancreatic cancer_Homo sapiens_hsa052120.19791510
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18457174
144Herpes simplex infection_Homo sapiens_hsa051680.18131946
145Viral myocarditis_Homo sapiens_hsa054160.15762655
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.14520545
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.14253986
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.14062939
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13592544

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