CCR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.67476490
2positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.56555743
3response to interleukin-15 (GO:0070672)7.19060778
4negative thymic T cell selection (GO:0045060)7.18369857
5cellular response to interleukin-15 (GO:0071350)6.86456773
6regulation of interleukin-2 biosynthetic process (GO:0045076)6.43506937
7positive regulation of gamma-delta T cell activation (GO:0046645)6.15128292
8T cell selection (GO:0045058)6.00139411
9regulation of isotype switching to IgG isotypes (GO:0048302)5.86829208
10thymic T cell selection (GO:0045061)5.71144895
11positive T cell selection (GO:0043368)5.67196420
12tyrosine phosphorylation of STAT protein (GO:0007260)5.15695952
13* tolerance induction (GO:0002507)4.91068002
14positive thymic T cell selection (GO:0045059)4.89811611
15positive regulation of interleukin-2 production (GO:0032743)4.88995888
16negative regulation of cell killing (GO:0031342)4.84351596
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.84351596
18regulation of gamma-delta T cell differentiation (GO:0045586)4.83760543
19positive regulation of natural killer cell differentiation (GO:0032825)4.78972599
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.54141839
21regulation of gamma-delta T cell activation (GO:0046643)4.53713880
22regulation of immunoglobulin secretion (GO:0051023)4.52255852
23interferon-gamma production (GO:0032609)4.51573497
24positive regulation of alpha-beta T cell proliferation (GO:0046641)4.39738481
25T cell costimulation (GO:0031295)4.39210915
26leukocyte aggregation (GO:0070486)4.38923126
27lymphocyte costimulation (GO:0031294)4.37419388
28regulation of alpha-beta T cell proliferation (GO:0046640)4.32599035
29T cell receptor signaling pathway (GO:0050852)4.30450603
30positive regulation of isotype switching (GO:0045830)4.18743154
31positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.15848774
32regulation of interleukin-2 production (GO:0032663)4.10931228
33regulation of regulatory T cell differentiation (GO:0045589)4.08697935
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.04649304
35regulation of T cell tolerance induction (GO:0002664)4.00574890
36negative regulation of T cell mediated immunity (GO:0002710)3.92691144
37positive regulation of natural killer cell mediated immunity (GO:0002717)3.91309314
38positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.91309314
39positive regulation of activated T cell proliferation (GO:0042104)3.91109013
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.90144850
41T-helper cell differentiation (GO:0042093)3.88671149
42CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.88671149
43T cell migration (GO:0072678)3.88026121
44DNA deamination (GO:0045006)3.85824552
45regulation of chronic inflammatory response (GO:0002676)3.80720936
46alpha-beta T cell differentiation (GO:0046632)3.79693366
47regulation of B cell receptor signaling pathway (GO:0050855)3.79320338
48regulation of isotype switching (GO:0045191)3.77512059
49positive regulation of DNA recombination (GO:0045911)3.76428015
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75293361
51positive regulation of granulocyte differentiation (GO:0030854)3.73815452
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72052707
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.72052707
54positive regulation of immunoglobulin production (GO:0002639)3.68664537
55alpha-beta T cell activation (GO:0046631)3.68317515
56regulation of immunoglobulin production (GO:0002637)3.67481577
57negative regulation of thymocyte apoptotic process (GO:0070244)3.66758400
58regulation of memory T cell differentiation (GO:0043380)3.66663435
59activated T cell proliferation (GO:0050798)3.64443692
60T cell lineage commitment (GO:0002360)3.62787715
61regulation of natural killer cell mediated immunity (GO:0002715)3.59522772
62regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.59522772
63inflammatory response to antigenic stimulus (GO:0002437)3.58929282
64antigen receptor-mediated signaling pathway (GO:0050851)3.58373493
65positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.57973159
66JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.52683312
67T cell homeostasis (GO:0043029)3.51778631
68antigen processing and presentation of endogenous antigen (GO:0019883)3.50739518
69positive regulation of mRNA catabolic process (GO:0061014)3.50380526
70positive regulation of B cell proliferation (GO:0030890)3.50360778
71positive regulation of B cell mediated immunity (GO:0002714)3.47176369
72positive regulation of immunoglobulin mediated immune response (GO:0002891)3.47176369
73regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.46710464
74positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.46710464
75modulation by virus of host process (GO:0019054)3.44381658
76positive regulation of cell fate commitment (GO:0010455)3.42487570
77regulation of T cell receptor signaling pathway (GO:0050856)3.41098648
78T cell differentiation involved in immune response (GO:0002292)3.40723485
79alpha-beta T cell differentiation involved in immune response (GO:0002293)3.40723485
80alpha-beta T cell activation involved in immune response (GO:0002287)3.40723485
81regulation of natural killer cell differentiation (GO:0032823)3.39406342
82positive regulation of T cell differentiation in thymus (GO:0033089)3.39087652
83positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.38259805
84positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.37491444
85regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.37491444
86T cell differentiation (GO:0030217)3.34731179
87behavioral response to nicotine (GO:0035095)3.33823546
88regulation of leukocyte mediated cytotoxicity (GO:0001910)3.32528738
89CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.32460645
90positive regulation of interleukin-4 production (GO:0032753)3.31636538
91regulation of cytokine production involved in inflammatory response (GO:1900015)3.28940414
92regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.26979880
93mast cell activation (GO:0045576)3.26616048
94positive regulation of B cell activation (GO:0050871)3.26175513
95regulation of interleukin-12 biosynthetic process (GO:0045075)3.25656630
96positive regulation of lymphocyte mediated immunity (GO:0002708)3.24816424
97regulation of immunoglobulin mediated immune response (GO:0002889)3.24531626
98NIK/NF-kappaB signaling (GO:0038061)3.24314476
99positive regulation of macrophage differentiation (GO:0045651)3.23428326
100positive regulation of T cell proliferation (GO:0042102)3.23252928
101modulation by symbiont of host cellular process (GO:0044068)3.22995716
102positive regulation of interleukin-17 production (GO:0032740)3.22119107
103positive regulation of humoral immune response (GO:0002922)3.22095014
104positive regulation of cell killing (GO:0031343)3.22036311
105regulation of T cell mediated cytotoxicity (GO:0001914)3.19475881
106positive regulation of defense response to virus by host (GO:0002230)3.17930182
107regulation of activated T cell proliferation (GO:0046006)3.17531409
108regulation of B cell proliferation (GO:0030888)3.17057324
109fucose catabolic process (GO:0019317)3.15141992
110L-fucose metabolic process (GO:0042354)3.15141992
111L-fucose catabolic process (GO:0042355)3.15141992
112myeloid dendritic cell activation (GO:0001773)3.14783458
113positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14506900
114regulation of B cell mediated immunity (GO:0002712)3.13016625
115positive regulation of tolerance induction (GO:0002645)3.12901413
116regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12457176
117positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.11412717
118negative regulation of lymphocyte mediated immunity (GO:0002707)2.99801771
119mucosal-associated lymphoid tissue development (GO:0048537)2.98150600
120Peyers patch development (GO:0048541)2.98150600
121mast cell degranulation (GO:0043303)2.94486748
122mast cell activation involved in immune response (GO:0002279)2.94486748
123regulation of mRNA catabolic process (GO:0061013)2.91711514
124CD4-positive, alpha-beta T cell activation (GO:0035710)2.90969165
125regulation of cell killing (GO:0031341)2.90281840
126negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.89017224
127negative regulation of T-helper cell differentiation (GO:0045623)2.88475964
128negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88475964
129T cell proliferation (GO:0042098)2.87122372
130negative regulation of adaptive immune response (GO:0002820)2.83143719
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.82221857
132T cell activation (GO:0042110)2.76771867
133RNA destabilization (GO:0050779)2.76396857
134lymph node development (GO:0048535)2.70196086
135regulation of tolerance induction (GO:0002643)2.67689348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.49559663
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.93898104
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.29997764
4E2F7_22180533_ChIP-Seq_HELA_Human5.39741350
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.44219735
6* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.80468942
7RUNX_20019798_ChIP-Seq_JUKART_Human3.71945691
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.08069985
9* MYB_26560356_Chip-Seq_TH2_Human3.07810427
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.06603822
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.01538426
12ZNF274_21170338_ChIP-Seq_K562_Hela2.84921666
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.64086754
14VDR_22108803_ChIP-Seq_LS180_Human2.60636300
15MYB_26560356_Chip-Seq_TH1_Human2.46853555
16MYC_22102868_ChIP-Seq_BL_Human2.42372545
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.37529898
18MAF_26560356_Chip-Seq_TH1_Human2.34406220
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33918947
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32947290
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.31600677
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00126196
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99351990
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.96502769
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.92782579
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91984551
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90500506
28UTX_26944678_Chip-Seq_JUKART_Human1.89155588
29MAF_26560356_Chip-Seq_TH2_Human1.78985218
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78403308
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75648256
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.71213656
33GATA3_27048872_Chip-Seq_THYMUS_Human1.69183340
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68050803
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66770873
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65670800
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64726803
38EZH2_22144423_ChIP-Seq_EOC_Human1.64384666
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.64168928
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59445720
41IRF1_19129219_ChIP-ChIP_H3396_Human1.55472571
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53019229
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52533967
44VDR_21846776_ChIP-Seq_THP-1_Human1.51429440
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48218973
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.47678067
47ER_23166858_ChIP-Seq_MCF-7_Human1.46840342
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46810738
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46240074
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.46145967
51TAF15_26573619_Chip-Seq_HEK293_Human1.45357694
52SCL_19346495_ChIP-Seq_HPC-7_Human1.45293096
53EWS_26573619_Chip-Seq_HEK293_Human1.44154078
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42424930
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41841808
56VDR_24763502_ChIP-Seq_THP-1_Human1.41438264
57GBX2_23144817_ChIP-Seq_PC3_Human1.41188647
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40566867
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39874794
60AR_21572438_ChIP-Seq_LNCaP_Human1.39426260
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.38224039
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.35758435
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34298728
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.32116312
65IGF1R_20145208_ChIP-Seq_DFB_Human1.30730985
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29439031
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28945834
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23690201
69SPI1_23547873_ChIP-Seq_NB4_Human1.22560473
70GATA3_26560356_Chip-Seq_TH2_Human1.22398173
71PU_27001747_Chip-Seq_BMDM_Mouse1.21455133
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19476057
73TCF7_22412390_ChIP-Seq_EML_Mouse1.19382744
74BCAT_22108803_ChIP-Seq_LS180_Human1.19261037
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.17841509
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17734082
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12930527
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12113517
79* SMRT_27268052_Chip-Seq_Bcells_Human1.12043050
80* GATA3_26560356_Chip-Seq_TH1_Human1.11860346
81FUS_26573619_Chip-Seq_HEK293_Human1.11525163
82P300_19829295_ChIP-Seq_ESCs_Human1.11382805
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10462885
84* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08674168
85* FOXA1_25329375_ChIP-Seq_VCAP_Human1.07576998
86* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07576998
87TP53_22573176_ChIP-Seq_HFKS_Human1.07519451
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07452331
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.03619005
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03254065
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02426921
92VDR_24787735_ChIP-Seq_THP-1_Human1.01676631
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01132030
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.00789027
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00659726
96STAT3_23295773_ChIP-Seq_U87_Human1.00526397
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00158431
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98431734
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.97518049
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97348376
101* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95502644
102FOXP3_21729870_ChIP-Seq_TREG_Human0.93689769
103SPI1_23127762_ChIP-Seq_K562_Human0.93585141
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93481886
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90086721
106* TCF4_23295773_ChIP-Seq_U87_Human0.88684455
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88655558
108FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87670664
109CBP_20019798_ChIP-Seq_JUKART_Human0.86771655
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86771655
111ELK1_19687146_ChIP-ChIP_HELA_Human0.86730100
112ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86409020
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86318036
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86070665
115GATA3_21878914_ChIP-Seq_MCF-7_Human0.85905590
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85322732
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84749971
118P53_22387025_ChIP-Seq_ESCs_Mouse0.84493727
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84289893
120AR_20517297_ChIP-Seq_VCAP_Human0.83618951
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82975148
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82975148
123VDR_23849224_ChIP-Seq_CD4+_Human0.82637607
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82258386
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80016972
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79768586
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.78737041
128GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77784786
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77565011
130CIITA_25753668_ChIP-Seq_RAJI_Human0.75055126
131* PRDM14_20953172_ChIP-Seq_ESCs_Human0.74588644
132KDM2B_26808549_Chip-Seq_DND41_Human0.74207396
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72568635
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.70020318
135SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.69757469
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.68513884
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.68461198
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68181944
139NMYC_18555785_Chip-Seq_ESCs_Mouse0.68158707
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67698133
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.67127499
142* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66819873
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.66198300
144GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65546129
145OCT4_18555785_Chip-Seq_ESCs_Mouse0.65502848
146MYC_18940864_ChIP-ChIP_HL60_Human0.64656103
147OCT4_21477851_ChIP-Seq_ESCs_Mouse0.64309848
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.63934800
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.63460940
150EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.62207057
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.62171854
152GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60815687
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.59809614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.28632722
2MP0005671_abnormal_response_to4.56016068
3MP0000685_abnormal_immune_system3.49691754
4MP0001790_abnormal_immune_system3.36014241
5MP0005387_immune_system_phenotype3.36014241
6MP0003300_gastrointestinal_ulcer2.99280317
7MP0001800_abnormal_humoral_immune2.98078994
8MP0001835_abnormal_antigen_presentation2.86410075
9MP0005000_abnormal_immune_tolerance2.77264352
10MP0003436_decreased_susceptibility_to2.75836519
11MP0003866_abnormal_defecation2.75228185
12MP0004381_abnormal_hair_follicle2.73978903
13MP0001873_stomach_inflammation2.71352826
14MP0002396_abnormal_hematopoietic_system2.68582183
15* MP0009333_abnormal_splenocyte_physiolog2.49626587
16MP0002405_respiratory_system_inflammati2.47403465
17MP0000703_abnormal_thymus_morphology2.46740735
18* MP0002723_abnormal_immune_serum2.45142396
19MP0009785_altered_susceptibility_to2.44919580
20MP0010155_abnormal_intestine_physiology2.40644420
21MP0002933_joint_inflammation2.38405502
22MP0002398_abnormal_bone_marrow2.37795654
23MP0006082_CNS_inflammation2.37135590
24MP0002420_abnormal_adaptive_immunity2.34900876
25MP0002166_altered_tumor_susceptibility2.32520723
26MP0001819_abnormal_immune_cell2.31756605
27MP0002452_abnormal_antigen_presenting2.30964832
28MP0002148_abnormal_hypersensitivity_rea2.25232362
29MP0002006_tumorigenesis2.08504672
30MP0005310_abnormal_salivary_gland2.05074122
31* MP0000716_abnormal_immune_system2.04339166
32MP0005025_abnormal_response_to2.02740621
33MP0002722_abnormal_immune_system2.00001513
34MP0004510_myositis1.97891713
35MP0001853_heart_inflammation1.94701273
36MP0003724_increased_susceptibility_to1.92343140
37MP0000689_abnormal_spleen_morphology1.84776665
38MP0003303_peritoneal_inflammation1.82415959
39MP0002254_reproductive_system_inflammat1.72480145
40* MP0002429_abnormal_blood_cell1.59411843
41MP0004947_skin_inflammation1.56946245
42MP0001986_abnormal_taste_sensitivity1.56518461
43MP0008872_abnormal_physiological_respon1.54846313
44MP0003646_muscle_fatigue1.51217584
45* MP0001845_abnormal_inflammatory_respons1.46596741
46MP0004142_abnormal_muscle_tone1.46547733
47MP0002009_preneoplasia1.45895174
48MP0002419_abnormal_innate_immunity1.43666131
49MP0000569_abnormal_digit_pigmentation1.42380096
50MP0001348_abnormal_lacrimal_gland1.41763050
51MP0005075_abnormal_melanosome_morpholog1.41493350
52MP0008057_abnormal_DNA_replication1.40582611
53MP0000490_abnormal_crypts_of1.37637295
54MP0004130_abnormal_muscle_cell1.35985727
55MP0005645_abnormal_hypothalamus_physiol1.34717159
56MP0003195_calcinosis1.31378784
57MP0005379_endocrine/exocrine_gland_phen1.31056964
58MP0003787_abnormal_imprinting1.28761129
59MP0004808_abnormal_hematopoietic_stem1.25113599
60MP0002102_abnormal_ear_morphology1.21866976
61MP0004742_abnormal_vestibular_system1.18911444
62MP0001968_abnormal_touch/_nociception1.17739958
63MP0000383_abnormal_hair_follicle1.16592509
64MP0000465_gastrointestinal_hemorrhage1.15719067
65MP0010094_abnormal_chromosome_stability1.12823106
66MP0003448_altered_tumor_morphology1.11909009
67MP0005551_abnormal_eye_electrophysiolog1.11521103
68MP0005076_abnormal_cell_differentiation1.09789175
69MP0005464_abnormal_platelet_physiology1.07235871
70MP0005389_reproductive_system_phenotype1.05603273
71MP0003693_abnormal_embryo_hatching1.05221736
72MP0001851_eye_inflammation1.02788385
73MP0000372_irregular_coat_pigmentation1.01932044
74MP0008877_abnormal_DNA_methylation1.00572813
75MP0005084_abnormal_gallbladder_morpholo1.00310430
76MP0002928_abnormal_bile_duct0.99820396
77MP0001533_abnormal_skeleton_physiology0.99449962
78MP0001881_abnormal_mammary_gland0.98676131
79MP0000858_altered_metastatic_potential0.97437336
80MP0009745_abnormal_behavioral_response0.96784799
81MP0002653_abnormal_ependyma_morphology0.95727755
82MP0006292_abnormal_olfactory_placode0.95212489
83MP0002998_abnormal_bone_remodeling0.94146225
84MP0008961_abnormal_basal_metabolism0.93346180
85MP0008995_early_reproductive_senescence0.90185171
86MP0005646_abnormal_pituitary_gland0.89887011
87MP0004885_abnormal_endolymph0.88368308
88MP0000627_abnormal_mammary_gland0.86939384
89MP0005397_hematopoietic_system_phenotyp0.86716130
90MP0001545_abnormal_hematopoietic_system0.86716130
91MP0002277_abnormal_respiratory_mucosa0.86664349
92MP0003011_delayed_dark_adaptation0.86042920
93MP0005174_abnormal_tail_pigmentation0.83612545
94MP0008469_abnormal_protein_level0.82833025
95MP0001485_abnormal_pinna_reflex0.82293222
96MP0002272_abnormal_nervous_system0.81969377
97MP0001346_abnormal_lacrimal_gland0.81262372
98MP0002019_abnormal_tumor_incidence0.81051707
99MP0002638_abnormal_pupillary_reflex0.80840626
100MP0002837_dystrophic_cardiac_calcinosis0.80668484
101MP0000427_abnormal_hair_cycle0.79500316
102MP0002163_abnormal_gland_morphology0.79206002
103MP0003045_fibrosis0.78854005
104MP0008007_abnormal_cellular_replicative0.77909457
105MP0001663_abnormal_digestive_system0.76861952
106MP0010352_gastrointestinal_tract_polyps0.74471673
107MP0002132_abnormal_respiratory_system0.73139241
108MP0008875_abnormal_xenobiotic_pharmacok0.73042667
109MP0001216_abnormal_epidermal_layer0.72634347
110MP0001765_abnormal_ion_homeostasis0.71704104
111MP0003077_abnormal_cell_cycle0.71673032
112MP0003111_abnormal_nucleus_morphology0.68540055
113MP0000015_abnormal_ear_pigmentation0.68231522
114MP0009764_decreased_sensitivity_to0.67588695
115MP0002736_abnormal_nociception_after0.67234054
116MP0003880_abnormal_central_pattern0.66758497
117MP0006072_abnormal_retinal_apoptosis0.66231453
118MP0002138_abnormal_hepatobiliary_system0.65712945
119MP0003252_abnormal_bile_duct0.64372729
120MP0005253_abnormal_eye_physiology0.64265470
121MP0003453_abnormal_keratinocyte_physiol0.64031459
122MP0002095_abnormal_skin_pigmentation0.63167136
123MP0005023_abnormal_wound_healing0.59408624
124MP0002876_abnormal_thyroid_physiology0.59387165
125MP0003795_abnormal_bone_structure0.56925118
126MP0000477_abnormal_intestine_morphology0.56202422
127MP0001501_abnormal_sleep_pattern0.54752208
128MP0001919_abnormal_reproductive_system0.54694481
129MP0002098_abnormal_vibrissa_morphology0.54018671
130MP0010678_abnormal_skin_adnexa0.52739347
131MP0000371_diluted_coat_color0.52635265
132MP0002693_abnormal_pancreas_physiology0.51518028
133MP0009765_abnormal_xenobiotic_induced0.51466041
134MP0000367_abnormal_coat/_hair0.48605141
135MP0005390_skeleton_phenotype0.43955751
136MP0005409_darkened_coat_color0.43471087
137MP0001191_abnormal_skin_condition0.43322072

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.67749349
2Abnormality of T cell number (HP:0011839)6.60361772
3Recurrent fungal infections (HP:0002841)5.32683450
4Chronic diarrhea (HP:0002028)5.29726685
5Recurrent cutaneous fungal infections (HP:0011370)5.26492189
6Chronic mucocutaneous candidiasis (HP:0002728)5.26492189
7Abnormality of T cells (HP:0002843)5.21681157
8Severe combined immunodeficiency (HP:0004430)5.08145060
9Panhypogammaglobulinemia (HP:0003139)4.76071889
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.69322871
11IgA deficiency (HP:0002720)4.69190163
12IgM deficiency (HP:0002850)4.46767948
13Stomatitis (HP:0010280)4.46232667
14B lymphocytopenia (HP:0010976)4.45916105
15Abnormality of B cell number (HP:0010975)4.45916105
16Combined immunodeficiency (HP:0005387)4.38357621
17Myositis (HP:0100614)4.37325622
18Elevated erythrocyte sedimentation rate (HP:0003565)4.13150683
19Optic neuritis (HP:0100653)4.10271804
20Retrobulbar optic neuritis (HP:0100654)4.10271804
21IgG deficiency (HP:0004315)3.99001010
22Abnormality of T cell physiology (HP:0011840)3.95172727
23Recurrent viral infections (HP:0004429)3.93941642
24Recurrent bronchitis (HP:0002837)3.79706071
25Eczematoid dermatitis (HP:0000976)3.71204900
26Increased IgM level (HP:0003496)3.63439103
27Pancreatic cysts (HP:0001737)3.60254294
28Orchitis (HP:0100796)3.49851761
29Abnormality of the fingertips (HP:0001211)3.42745473
30Cheilitis (HP:0100825)3.36496076
31Joint swelling (HP:0001386)3.33294424
32Congenital stationary night blindness (HP:0007642)3.30788826
33Abnormality of eosinophils (HP:0001879)3.23345936
34Pulmonary infiltrates (HP:0002113)3.18802806
35Keratoconjunctivitis (HP:0001096)3.16109911
36Pustule (HP:0200039)3.15602667
37Thyroiditis (HP:0100646)3.09106521
38Hemoptysis (HP:0002105)3.08157050
39Autoimmune hemolytic anemia (HP:0001890)3.07282418
40Pancreatic fibrosis (HP:0100732)3.06850840
41Eosinophilia (HP:0001880)3.04085890
42Vasculitis (HP:0002633)3.01446776
43Meningitis (HP:0001287)2.94174444
44Molar tooth sign on MRI (HP:0002419)2.91568226
45Abnormality of midbrain morphology (HP:0002418)2.91568226
46Increased IgE level (HP:0003212)2.85889176
47Genetic anticipation (HP:0003743)2.84177438
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.83948989
49Chronic hepatic failure (HP:0100626)2.83025872
50Leukocytosis (HP:0001974)2.80060271
51Lymphoma (HP:0002665)2.78609660
52Inflammation of the large intestine (HP:0002037)2.75387132
53Keratoconjunctivitis sicca (HP:0001097)2.73551596
54True hermaphroditism (HP:0010459)2.71939435
55Attenuation of retinal blood vessels (HP:0007843)2.69885364
56Lymphopenia (HP:0001888)2.69624295
57Abnormal rod and cone electroretinograms (HP:0008323)2.68243245
58Mediastinal lymphadenopathy (HP:0100721)2.67979360
59Recurrent skin infections (HP:0001581)2.67494749
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.67193010
61Chronic otitis media (HP:0000389)2.64941873
62Abnormality of the renal cortex (HP:0011035)2.60517031
63Granulocytopenia (HP:0001913)2.59065485
64Progressive cerebellar ataxia (HP:0002073)2.56219876
65Gastrointestinal inflammation (HP:0004386)2.55447134
66Chronic obstructive pulmonary disease (HP:0006510)2.54652209
67Obstructive lung disease (HP:0006536)2.54652209
68Progressive inability to walk (HP:0002505)2.54233470
69Arterial thrombosis (HP:0004420)2.51771624
70Persistence of primary teeth (HP:0006335)2.51482354
71Recurrent sinusitis (HP:0011108)2.50949193
72Abolished electroretinogram (ERG) (HP:0000550)2.48552415
73Hypergammaglobulinemia (HP:0010702)2.47366410
74Stomach cancer (HP:0012126)2.47155087
75Encephalitis (HP:0002383)2.45414396
76Pendular nystagmus (HP:0012043)2.44304782
77Abnormal hair whorl (HP:0010721)2.43412484
783-Methylglutaconic aciduria (HP:0003535)2.40803856
79Nephronophthisis (HP:0000090)2.37354294
80Thrombocytosis (HP:0001894)2.36628191
81Nasal polyposis (HP:0100582)2.36333336
82Chromsome breakage (HP:0040012)2.33260744
83Inability to walk (HP:0002540)2.30759498
84Abnormality of the prostate (HP:0008775)2.30072490
85Decreased central vision (HP:0007663)2.29313945
86Gangrene (HP:0100758)2.25932935
87Gastrointestinal infarctions (HP:0005244)2.13098089
88Gaze-evoked nystagmus (HP:0000640)2.11035797
89Periodontitis (HP:0000704)2.10222267
90Abnormality of the renal medulla (HP:0100957)2.10020963
91Renal cortical cysts (HP:0000803)2.08965295
92Aplasia/Hypoplasia of the spleen (HP:0010451)2.05995995
93Acute myeloid leukemia (HP:0004808)2.05490114
94Asplenia (HP:0001746)2.03317164
95Congenital, generalized hypertrichosis (HP:0004540)2.02632253
96Hypoplasia of the thymus (HP:0000778)2.01128453
97Bronchitis (HP:0012387)2.00255760
98Pulmonary fibrosis (HP:0002206)1.97492428
99Alveolar cell carcinoma (HP:0006519)1.97020245
100Increased density of long bones (HP:0006392)1.94737928
101Cystic liver disease (HP:0006706)1.94723317
102Leukopenia (HP:0001882)1.94054994
103Gastrointestinal stroma tumor (HP:0100723)1.93042321
104Hyperventilation (HP:0002883)1.92775907
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92727713
106Dynein arm defect of respiratory motile cilia (HP:0012255)1.92003531
107Absent/shortened dynein arms (HP:0200106)1.92003531
108Keratitis (HP:0000491)1.90292114
109Hypochromic anemia (HP:0001931)1.90194567
110Polydipsia (HP:0001959)1.89778222
111Abnormal drinking behavior (HP:0030082)1.89778222
112Pulmonary embolism (HP:0002204)1.89213938
113Arthralgia (HP:0002829)1.89148405
114Keratoconus (HP:0000563)1.88591547
115Increased corneal curvature (HP:0100692)1.88591547
116Absent hand (HP:0004050)1.88498503
117Decreased circulating renin level (HP:0003351)1.86954082
118Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86424620
119Large for gestational age (HP:0001520)1.85339074
120Clumsiness (HP:0002312)1.84887667
121Neoplasm of the tracheobronchial system (HP:0100552)1.84122886
122Type II lissencephaly (HP:0007260)1.82909664
123Abnormality of the columella (HP:0009929)1.82368333
124Chest pain (HP:0100749)1.79696138
125Abnormality of chromosome stability (HP:0003220)1.78197912
126Hypoproteinemia (HP:0003075)1.77883103
127Aplasia cutis congenita (HP:0001057)1.77225711
128Furrowed tongue (HP:0000221)1.77101404
129Ectopic kidney (HP:0000086)1.75281610
130Abnormality of the preputium (HP:0100587)1.75128880
131Myelodysplasia (HP:0002863)1.75101274
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74660306
133Glomerulopathy (HP:0100820)1.74521748
134Gingivitis (HP:0000230)1.73966498
135Recurrent abscess formation (HP:0002722)1.73434864
136Hemiplegia (HP:0002301)1.73081397
137Abnormality of the pons (HP:0007361)1.72550704
138Chronic sinusitis (HP:0011109)1.71904857
139Agammaglobulinemia (HP:0004432)1.71558623
140Ureteral stenosis (HP:0000071)1.71271185
141Bile duct proliferation (HP:0001408)1.70900103
142Abnormal biliary tract physiology (HP:0012439)1.70900103
143Gingival bleeding (HP:0000225)1.70139188
144Bronchiectasis (HP:0002110)1.69935907
145Abnormality of the pleura (HP:0002103)1.69450975
146Cutis marmorata (HP:0000965)1.69134820
147Neutropenia (HP:0001875)1.69115889
148Abnormality of the frontal sinuses (HP:0002687)1.69110916
149Abnormality of the nasal mucosa (HP:0000433)1.67973864
150Amaurosis fugax (HP:0100576)1.67320424
151Dislocated radial head (HP:0003083)1.67169632
152Fair hair (HP:0002286)1.66544754
153Prolonged bleeding time (HP:0003010)1.66016660
154Hyperalaninemia (HP:0003348)1.65250353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.52467300
2MAP4K15.31509850
3JAK33.96657611
4FRK3.55954604
5ITK2.95607214
6MAP3K142.92612265
7ZAP702.88722824
8CAMKK22.78298708
9NLK2.56706237
10TEC2.18234412
11STK102.11660866
12FGFR42.10161634
13EEF2K2.08161959
14BLK1.95503362
15JAK11.89588666
16CAMKK11.88092118
17TYK21.77416938
18LCK1.73785018
19MST41.73139779
20EPHA31.66255948
21FGFR31.61324075
22TLK11.59663559
23GRK11.59143857
24IKBKE1.57996531
25SYK1.48424410
26ACVR1B1.45495740
27HCK1.42170994
28CDK121.41268033
29BMPR1B1.39286884
30MKNK21.36593313
31MAP4K21.35975639
32PRKCQ1.33735070
33BTK1.31729493
34CHUK1.30993543
35PIM21.27434814
36IKBKB1.25014572
37PINK11.19601756
38WNK41.15744460
39IRAK41.13620096
40MAP3K71.13301516
41RIPK41.10993920
42SIK31.08514176
43CLK11.07837926
44NME21.07154659
45CSK1.04165676
46TNK21.00923554
47ZAK1.00779360
48MAPK130.99166654
49EPHB10.99085023
50WNK30.95887672
51MAP2K60.94392401
52PIM10.93485208
53GRK60.93124543
54JAK20.92356740
55CDC70.91168368
56IRAK10.88088580
57TYRO30.86644863
58ADRBK10.80342586
59TBK10.79566784
60CDK40.78937733
61PAK30.77630194
62TSSK60.75837859
63INSRR0.75393338
64MKNK10.72444113
65CDK60.72283384
66LYN0.68804562
67FES0.66727948
68CDK90.66078056
69STK110.64280784
70OXSR10.62144804
71RPS6KA40.61927038
72STK240.61587245
73IRAK30.59741736
74NUAK10.59156286
75BMPR20.58920115
76SRPK10.57881444
77KIT0.57548454
78SIK20.56689180
79PRKCH0.56563779
80BRD40.55441507
81TAF10.54585869
82TRIM280.54448204
83NEK20.54436161
84MAPKAPK30.54087021
85HIPK20.53332412
86YES10.52210523
87PIK3CA0.50734164
88MAP3K40.50221871
89CDK80.49665336
90MAP3K110.49399652
91DYRK20.48839386
92TGFBR10.47634208
93TNIK0.47020860
94DAPK20.46614567
95PDK10.46564129
96MARK30.46344281
97CAMK40.45810785
98KDR0.44805950
99PIK3CG0.44394759
100MAP3K130.43131693
101CAMK10.42496666
102MAPKAPK20.41661308
103FGFR20.41569327
104GRK50.40985295
105MELK0.40620184
106WNK10.40526722
107TRPM70.38997217
108PRKCG0.38851781
109ALK0.38395632
110VRK10.38146791
111RPS6KA50.38085556
112ATR0.37741054
113PLK30.37612701
114GRK70.37332216
115STK40.37311992
116CHEK10.36823290
117RPS6KA60.36017175
118ADRBK20.35974286
119STK390.35413087
120ATM0.34857461
121PTK2B0.34694787
122NEK90.34645018
123IGF1R0.34413843
124MAPK40.34052041
125RAF10.33570801
126BUB10.33456869
127MARK20.32973235
128NTRK20.32498466
129SGK20.32330443
130CDK30.32230574
131MAPK30.31718544
132PASK0.29092437
133LRRK20.28931136
134AURKB0.28819494
135TAOK30.28465246
136RPS6KB10.28210938
137CASK0.27751185
138MAPK70.27729707
139EIF2AK20.27100969
140SGK10.25707947
141MAPK110.25175207
142PDGFRB0.24940875
143PRPF4B0.24215247
144SGK30.23486674
145MAPK120.23237548

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.99400022
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.42292317
3Allograft rejection_Homo sapiens_hsa053304.33486380
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.98391267
5Autoimmune thyroid disease_Homo sapiens_hsa053203.86267768
6T cell receptor signaling pathway_Homo sapiens_hsa046603.36939360
7Asthma_Homo sapiens_hsa053103.21232783
8Measles_Homo sapiens_hsa051622.64266608
9Graft-versus-host disease_Homo sapiens_hsa053322.48129246
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.48022320
11Jak-STAT signaling pathway_Homo sapiens_hsa046302.40089592
12Hematopoietic cell lineage_Homo sapiens_hsa046402.30456879
13Type I diabetes mellitus_Homo sapiens_hsa049402.10767522
14Phototransduction_Homo sapiens_hsa047441.99752235
15* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.95054986
16Linoleic acid metabolism_Homo sapiens_hsa005911.82308351
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81174030
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72466517
19Leishmaniasis_Homo sapiens_hsa051401.56092476
20Antigen processing and presentation_Homo sapiens_hsa046121.48817565
21Viral myocarditis_Homo sapiens_hsa054161.45733683
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43557059
23Osteoclast differentiation_Homo sapiens_hsa043801.39407592
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35473894
25Nitrogen metabolism_Homo sapiens_hsa009101.32597738
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30691312
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27145711
28Caffeine metabolism_Homo sapiens_hsa002321.24853137
29Herpes simplex infection_Homo sapiens_hsa051681.21175799
30Basal transcription factors_Homo sapiens_hsa030221.14642274
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14541827
32RNA polymerase_Homo sapiens_hsa030201.14370102
33Regulation of autophagy_Homo sapiens_hsa041401.13909039
34Non-homologous end-joining_Homo sapiens_hsa034501.12045657
35Toxoplasmosis_Homo sapiens_hsa051451.11102304
36HTLV-I infection_Homo sapiens_hsa051661.10064941
37Acute myeloid leukemia_Homo sapiens_hsa052211.08485340
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07382413
39Morphine addiction_Homo sapiens_hsa050321.06652719
40* Chemokine signaling pathway_Homo sapiens_hsa040621.03453042
41Hepatitis B_Homo sapiens_hsa051611.02469448
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01775989
43TNF signaling pathway_Homo sapiens_hsa046681.00567004
44Selenocompound metabolism_Homo sapiens_hsa004500.99334622
45Rheumatoid arthritis_Homo sapiens_hsa053230.97792017
46Fanconi anemia pathway_Homo sapiens_hsa034600.97583424
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.96886647
48B cell receptor signaling pathway_Homo sapiens_hsa046620.94692346
49Ether lipid metabolism_Homo sapiens_hsa005650.94307685
50Homologous recombination_Homo sapiens_hsa034400.88299474
51Nicotine addiction_Homo sapiens_hsa050330.88117913
52Olfactory transduction_Homo sapiens_hsa047400.87134234
53Influenza A_Homo sapiens_hsa051640.84725013
54Dorso-ventral axis formation_Homo sapiens_hsa043200.83189509
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82124769
56p53 signaling pathway_Homo sapiens_hsa041150.79989930
57Epstein-Barr virus infection_Homo sapiens_hsa051690.79419844
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79104629
59Prolactin signaling pathway_Homo sapiens_hsa049170.78689141
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78535746
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77380240
62DNA replication_Homo sapiens_hsa030300.76079180
63RNA degradation_Homo sapiens_hsa030180.74743690
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74603969
65Glycerolipid metabolism_Homo sapiens_hsa005610.74470402
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73905884
67* Viral carcinogenesis_Homo sapiens_hsa052030.72953731
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.71147907
69Protein export_Homo sapiens_hsa030600.70853976
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70676336
71Circadian rhythm_Homo sapiens_hsa047100.68712278
72Chronic myeloid leukemia_Homo sapiens_hsa052200.68476252
73Ribosome_Homo sapiens_hsa030100.68144516
74Malaria_Homo sapiens_hsa051440.66873953
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.65432456
76Pancreatic cancer_Homo sapiens_hsa052120.64635381
77Taste transduction_Homo sapiens_hsa047420.63648392
78Apoptosis_Homo sapiens_hsa042100.62905317
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62554974
80Tuberculosis_Homo sapiens_hsa051520.62164211
81Oxidative phosphorylation_Homo sapiens_hsa001900.62164105
82Notch signaling pathway_Homo sapiens_hsa043300.60833855
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60100734
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59597577
85Mismatch repair_Homo sapiens_hsa034300.58567032
86Cell cycle_Homo sapiens_hsa041100.56716106
87Spliceosome_Homo sapiens_hsa030400.56388686
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56058661
89Serotonergic synapse_Homo sapiens_hsa047260.56058333
90ABC transporters_Homo sapiens_hsa020100.55601804
91Hepatitis C_Homo sapiens_hsa051600.55213760
92Small cell lung cancer_Homo sapiens_hsa052220.55050580
93Arachidonic acid metabolism_Homo sapiens_hsa005900.52470772
94MicroRNAs in cancer_Homo sapiens_hsa052060.51808212
95Type II diabetes mellitus_Homo sapiens_hsa049300.51582572
96Legionellosis_Homo sapiens_hsa051340.51459447
97Prostate cancer_Homo sapiens_hsa052150.50131544
98Staphylococcus aureus infection_Homo sapiens_hsa051500.49600736
99Colorectal cancer_Homo sapiens_hsa052100.49426820
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49088588
101Shigellosis_Homo sapiens_hsa051310.48902762
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47723926
103Butanoate metabolism_Homo sapiens_hsa006500.47031021
104One carbon pool by folate_Homo sapiens_hsa006700.46497106
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46454509
106RNA transport_Homo sapiens_hsa030130.46156640
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45808891
108Tryptophan metabolism_Homo sapiens_hsa003800.45691925
109mRNA surveillance pathway_Homo sapiens_hsa030150.45087849
110Parkinsons disease_Homo sapiens_hsa050120.44260627
111MAPK signaling pathway_Homo sapiens_hsa040100.41991945
112Ras signaling pathway_Homo sapiens_hsa040140.41482056
113Calcium signaling pathway_Homo sapiens_hsa040200.40756725
114Circadian entrainment_Homo sapiens_hsa047130.40193397
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39739904
116HIF-1 signaling pathway_Homo sapiens_hsa040660.39292009
117Base excision repair_Homo sapiens_hsa034100.38252508
118Cholinergic synapse_Homo sapiens_hsa047250.38097390
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37619603
120FoxO signaling pathway_Homo sapiens_hsa040680.37293263
121GABAergic synapse_Homo sapiens_hsa047270.36857491
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34748591
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33619226
124Platelet activation_Homo sapiens_hsa046110.32182859
125cAMP signaling pathway_Homo sapiens_hsa040240.32014074
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31551398
127Renal cell carcinoma_Homo sapiens_hsa052110.31278011
128Glutamatergic synapse_Homo sapiens_hsa047240.31137182
129Oxytocin signaling pathway_Homo sapiens_hsa049210.31023276
130Inositol phosphate metabolism_Homo sapiens_hsa005620.30528388
131Pathways in cancer_Homo sapiens_hsa052000.30061739
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29628704
133Thyroid cancer_Homo sapiens_hsa052160.28417571
134Pertussis_Homo sapiens_hsa051330.26900046
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25009040
136Salmonella infection_Homo sapiens_hsa051320.23357360
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23172503
138African trypanosomiasis_Homo sapiens_hsa051430.20460762
139Non-small cell lung cancer_Homo sapiens_hsa052230.16191821
140Systemic lupus erythematosus_Homo sapiens_hsa053220.15192215
141Rap1 signaling pathway_Homo sapiens_hsa040150.14558185
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.13825663
143VEGF signaling pathway_Homo sapiens_hsa043700.12181824
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11985243

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