CCR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.91782523
2modulation by symbiont of host defense response (GO:0052031)6.38447703
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.38447703
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.38447703
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.38447703
6modulation by symbiont of host immune response (GO:0052553)6.38447703
7positive regulation by symbiont of host defense response (GO:0052509)6.38447703
8microglial cell activation (GO:0001774)5.97184886
9regulation of interferon-beta biosynthetic process (GO:0045357)5.42784176
10macrophage activation involved in immune response (GO:0002281)5.15882822
11neutrophil activation involved in immune response (GO:0002283)4.81480569
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.31052979
13negative regulation of cell killing (GO:0031342)4.30465135
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30465135
15positive regulation of interferon-alpha production (GO:0032727)4.29715185
16interferon-gamma production (GO:0032609)4.28564253
17regulation of B cell receptor signaling pathway (GO:0050855)4.26084794
18regulation of vitamin D biosynthetic process (GO:0060556)4.25493695
19macrophage activation (GO:0042116)4.18363662
20response to host immune response (GO:0052572)4.11847284
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.11847284
22regulation of interferon-alpha production (GO:0032647)4.07551822
23cellular extravasation (GO:0045123)4.05569878
24respiratory burst (GO:0045730)4.00611583
25positive regulation of chemokine secretion (GO:0090197)3.97865407
26regulation of T-helper 1 cell differentiation (GO:0045625)3.95159185
27myeloid cell activation involved in immune response (GO:0002275)3.94931248
28response to peptidoglycan (GO:0032494)3.94153000
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.91567870
30regulation of chronic inflammatory response (GO:0002676)3.91098092
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.80499817
32immunoglobulin mediated immune response (GO:0016064)3.79039469
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.78961817
34response to host (GO:0075136)3.78961817
35response to host defenses (GO:0052200)3.78961817
36positive regulation of monocyte chemotaxis (GO:0090026)3.74852773
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.73552986
38regulation of T cell tolerance induction (GO:0002664)3.72356016
39granulocyte activation (GO:0036230)3.69012240
40T-helper 1 type immune response (GO:0042088)3.64701096
41neutrophil activation (GO:0042119)3.62651484
42positive regulation of cellular amide metabolic process (GO:0034250)3.61756662
43T cell migration (GO:0072678)3.61423813
44positive regulation of antigen processing and presentation (GO:0002579)3.58526933
45NIK/NF-kappaB signaling (GO:0038061)3.57275246
46positive regulation of gamma-delta T cell activation (GO:0046645)3.55891190
47positive regulation of chemokine biosynthetic process (GO:0045080)3.54274036
48positive regulation of type 2 immune response (GO:0002830)3.51945140
49regulation of podosome assembly (GO:0071801)3.50226788
50regulation of cytokine secretion involved in immune response (GO:0002739)3.44902893
51activated T cell proliferation (GO:0050798)3.43867457
52negative regulation of cytokine production involved in immune response (GO:0002719)3.40633869
53glycosphingolipid catabolic process (GO:0046479)3.36954682
54regulation of vitamin metabolic process (GO:0030656)3.35657316
55* cellular defense response (GO:0006968)3.32726152
56regulation of mononuclear cell migration (GO:0071675)3.31608120
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30955517
58positive regulation of mast cell activation (GO:0033005)3.30287493
59germinal center formation (GO:0002467)3.28498545
60regulation of gamma-delta T cell activation (GO:0046643)3.28336960
61regulation of tolerance induction (GO:0002643)3.28237259
62regulation of mast cell degranulation (GO:0043304)3.25744433
63regulation of chemokine biosynthetic process (GO:0045073)3.24531628
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.23790927
65cellular response to thyroid hormone stimulus (GO:0097067)3.21510895
66myeloid leukocyte activation (GO:0002274)3.20831586
67positive regulation of interferon-beta production (GO:0032728)3.18588061
68lymphocyte chemotaxis (GO:0048247)3.18400596
69G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.17918740
70regulation of monocyte chemotaxis (GO:0090025)3.17798554
71detection of other organism (GO:0098543)3.17594328
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16714741
73regulation of interleukin-12 production (GO:0032655)3.16369963
74cellular response to interleukin-15 (GO:0071350)3.16218839
75detection of molecule of bacterial origin (GO:0032490)3.15972112
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.15444223
77purinergic nucleotide receptor signaling pathway (GO:0035590)3.15086070
78regulation of mast cell activation (GO:0033003)3.12352418
79regulation of antigen processing and presentation (GO:0002577)3.11786847
80lipopolysaccharide-mediated signaling pathway (GO:0031663)3.11128402
81positive regulation of heat generation (GO:0031652)3.09546318
82negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.08056088
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07222516
84mast cell activation (GO:0045576)3.07005306
85response to muramyl dipeptide (GO:0032495)3.05610979
86regulation of mast cell activation involved in immune response (GO:0033006)3.05574849
87negative regulation of granulocyte differentiation (GO:0030853)3.05363848
88positive regulation of lymphocyte migration (GO:2000403)3.05291452
89positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.03241689
90positive regulation of mast cell activation involved in immune response (GO:0033008)3.02863673
91positive regulation of mast cell degranulation (GO:0043306)3.02863673
92regulation of chemokine-mediated signaling pathway (GO:0070099)3.02380159
93regulation of lymphocyte chemotaxis (GO:1901623)3.02293594
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02213280
95defense response to protozoan (GO:0042832)3.01952020
96regulation of type 2 immune response (GO:0002828)3.01549653
97glycolipid catabolic process (GO:0019377)3.01381374
98negative regulation of interleukin-17 production (GO:0032700)3.01334070
99I-kappaB phosphorylation (GO:0007252)3.00849412
100positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.00574332
101positive regulation of T cell migration (GO:2000406)2.99801487
102myeloid dendritic cell activation (GO:0001773)2.99338246
103positive regulation of NF-kappaB import into nucleus (GO:0042346)2.99140626
104regulation of interleukin-2 biosynthetic process (GO:0045076)2.97979984
105positive regulation of tolerance induction (GO:0002645)2.97807527
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97701710
107cellular response to interferon-beta (GO:0035458)2.97223990
108cellular response to interferon-gamma (GO:0071346)2.96774985
109positive regulation of B cell differentiation (GO:0045579)2.96360004
110negative regulation of interleukin-12 production (GO:0032695)2.96022315
111regulation of fever generation (GO:0031620)2.96013017
112B cell mediated immunity (GO:0019724)2.95815842
113regulation of chemokine secretion (GO:0090196)2.95450725
114tolerance induction (GO:0002507)2.95112473
115positive regulation of T-helper 1 type immune response (GO:0002827)2.93971448
116regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92961135
117regulation of natural killer cell mediated immunity (GO:0002715)2.92961135
118myeloid dendritic cell differentiation (GO:0043011)2.89973138
119type I interferon signaling pathway (GO:0060337)2.89034944
120cellular response to type I interferon (GO:0071357)2.89034944
121detection of bacterium (GO:0016045)2.88798552
122negative regulation of T cell mediated immunity (GO:0002710)2.87574925
123response to type I interferon (GO:0034340)2.87291994
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86593424
125dendritic cell differentiation (GO:0097028)2.86498452
126regulation of lymphocyte migration (GO:2000401)2.85766500
127detection of external biotic stimulus (GO:0098581)2.85602790
128B cell receptor signaling pathway (GO:0050853)2.85097435
129regulation of T-helper 2 cell differentiation (GO:0045628)2.84890189
130antigen processing and presentation of endogenous antigen (GO:0019883)2.84808126
131interferon-gamma-mediated signaling pathway (GO:0060333)2.84755718
132negative regulation of nitric oxide biosynthetic process (GO:0045019)2.84389480
133positive regulation of interferon-gamma production (GO:0032729)2.84019819
134response to interferon-gamma (GO:0034341)2.81958600
135oligosaccharide catabolic process (GO:0009313)2.81848354
136negative regulation of myeloid cell apoptotic process (GO:0033033)2.80398518
137response to interleukin-15 (GO:0070672)2.79620838
138regulation of macrophage chemotaxis (GO:0010758)2.79436093
139positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.79241487
140positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.78564670
141production of molecular mediator involved in inflammatory response (GO:0002532)2.78418155
142positive regulation of T cell chemotaxis (GO:0010820)2.78170829
143regulation of T cell chemotaxis (GO:0010819)2.78170829
144regulation of interleukin-8 biosynthetic process (GO:0045414)2.77778521
145response to protozoan (GO:0001562)2.77245210
146positive regulation of interleukin-12 production (GO:0032735)2.76512751
147monocyte chemotaxis (GO:0002548)2.76329450
148natural killer cell activation (GO:0030101)2.75839701
149regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.75648105
150neutrophil chemotaxis (GO:0030593)2.75351174
151* cellular response to lipopolysaccharide (GO:0071222)2.75170656
152negative regulation of production of molecular mediator of immune response (GO:0002701)2.75073821
153amino sugar catabolic process (GO:0046348)2.73793564
154* cellular response to molecule of bacterial origin (GO:0071219)2.71280624
155positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70467615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.59866552
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.58658206
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.20496780
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.88671656
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.79972184
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.32319893
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.71812456
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56425058
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54525245
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.47340792
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.37868206
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23875636
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93651545
14RUNX_20019798_ChIP-Seq_JUKART_Human2.70835636
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64037561
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41231909
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41123634
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17221875
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11187211
20* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09051083
21SPI1_23547873_ChIP-Seq_NB4_Human2.05459798
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04219817
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.01410246
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.00439011
25VDR_24787735_ChIP-Seq_THP-1_Human1.98247692
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.97795920
27* MYB_26560356_Chip-Seq_TH2_Human1.89871723
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.89396399
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88614399
30SCL_19346495_ChIP-Seq_HPC-7_Human1.82323825
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80560358
32PU_27001747_Chip-Seq_BMDM_Mouse1.76567578
33SPI1_23127762_ChIP-Seq_K562_Human1.74256959
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65513245
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64688988
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.55005664
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52674591
38MYB_26560356_Chip-Seq_TH1_Human1.49569625
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45791151
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45128500
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44684248
42VDR_24763502_ChIP-Seq_THP-1_Human1.39927802
43MAF_26560356_Chip-Seq_TH1_Human1.38308623
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30132799
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28631850
46GATA1_22025678_ChIP-Seq_K562_Human1.28116653
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27241658
48GATA3_27048872_Chip-Seq_THYMUS_Human1.27032148
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24352871
50GATA3_26560356_Chip-Seq_TH2_Human1.23902727
51CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22279475
52* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21527226
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.20006985
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.19844537
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19329889
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18913607
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18883746
58KDM2B_26808549_Chip-Seq_DND41_Human1.16948699
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16210127
60GATA1_19941826_ChIP-Seq_K562_Human1.14910643
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12896632
62* LXR_22292898_ChIP-Seq_THP-1_Human1.11893382
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11145128
64MYC_22102868_ChIP-Seq_BL_Human1.09729844
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07852380
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06391050
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05425912
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04645630
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04370330
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04118351
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02683759
72TFEB_21752829_ChIP-Seq_HELA_Human1.00052880
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98371941
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98095375
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95948022
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94795054
77STAT1_20625510_ChIP-Seq_HELA_Human0.94694914
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94553504
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93958882
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.93309182
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91991285
82UTX_26944678_Chip-Seq_JUKART_Human0.90978974
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90465111
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89683242
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89549877
86EGR1_19032775_ChIP-ChIP_M12_Human0.88905455
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88505992
88CJUN_26792858_Chip-Seq_BT549_Human0.87005592
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83278930
90GATA2_19941826_ChIP-Seq_K562_Human0.82836352
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82121592
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.81092346
93RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80846909
94VDR_21846776_ChIP-Seq_THP-1_Human0.79799437
95BCL6_27268052_Chip-Seq_Bcells_Human0.79035916
96TCF7_22412390_ChIP-Seq_EML_Mouse0.78889755
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78432469
98SMRT_27268052_Chip-Seq_Bcells_Human0.77549403
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77368557
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77368557
101ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77198036
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76656256
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76497035
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74982993
105BCOR_27268052_Chip-Seq_Bcells_Human0.74781231
106WT1_19549856_ChIP-ChIP_CCG9911_Human0.74299361
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72213293
108TP53_16413492_ChIP-PET_HCT116_Human0.70761033
109PU1_27457419_Chip-Seq_LIVER_Mouse0.70369266
110KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.68847903
111GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68785184
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.68411166
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.67949439
114NCOR1_26117541_ChIP-Seq_K562_Human0.67402135
115SOX2_20726797_ChIP-Seq_SW620_Human0.65860746
116* GATA1_19941827_ChIP-Seq_MEL_Mouse0.65684176
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64799518
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62608412
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.61630109
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.61280662
121MAF_26560356_Chip-Seq_TH2_Human0.60041244
122JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58869830
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.58541043
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.56769697
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.56547539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.32581269
2MP0001835_abnormal_antigen_presentation4.57777638
3* MP0005671_abnormal_response_to3.99573303
4MP0003436_decreased_susceptibility_to3.41950509
5MP0005000_abnormal_immune_tolerance3.25050296
6* MP0002419_abnormal_innate_immunity3.22355822
7* MP0002148_abnormal_hypersensitivity_rea3.16464934
8MP0009785_altered_susceptibility_to3.10121042
9MP0003724_increased_susceptibility_to3.05358800
10MP0005058_abnormal_lysosome_morphology3.01663645
11MP0003303_peritoneal_inflammation2.92254674
12* MP0005025_abnormal_response_to2.91358647
13* MP0001800_abnormal_humoral_immune2.81038259
14* MP0002452_abnormal_antigen_presenting2.80735792
15MP0005387_immune_system_phenotype2.77330597
16MP0001790_abnormal_immune_system2.77330597
17MP0003191_abnormal_cellular_cholesterol2.75123511
18* MP0002723_abnormal_immune_serum2.69840215
19* MP0001819_abnormal_immune_cell2.47410777
20* MP0002420_abnormal_adaptive_immunity2.45403397
21MP0005464_abnormal_platelet_physiology2.40226789
22MP0003172_abnormal_lysosome_physiology2.34165623
23MP0003448_altered_tumor_morphology2.13508473
24MP0000685_abnormal_immune_system2.12393320
25MP0002139_abnormal_hepatobiliary_system2.10705076
26MP0001533_abnormal_skeleton_physiology2.10485455
27MP0003690_abnormal_glial_cell2.08306312
28MP0004510_myositis1.99821600
29MP0002405_respiratory_system_inflammati1.97531032
30MP0005451_abnormal_body_composition1.96798510
31* MP0001845_abnormal_inflammatory_respons1.85481273
32MP0001851_eye_inflammation1.76031175
33MP0003075_altered_response_to1.75954825
34MP0001853_heart_inflammation1.75495471
35* MP0000716_abnormal_immune_system1.73912056
36MP0009333_abnormal_splenocyte_physiolog1.72577209
37MP0005166_decreased_susceptibility_to1.71018774
38* MP0008469_abnormal_protein_level1.68790937
39MP0005310_abnormal_salivary_gland1.63804570
40* MP0002398_abnormal_bone_marrow1.59402168
41MP0002998_abnormal_bone_remodeling1.59201858
42MP0005167_abnormal_blood-brain_barrier1.54111293
43MP0003300_gastrointestinal_ulcer1.48764391
44MP0004947_skin_inflammation1.47554914
45MP0000689_abnormal_spleen_morphology1.46675089
46MP0002006_tumorigenesis1.44524963
47* MP0000343_altered_response_to1.41778283
48* MP0010155_abnormal_intestine_physiology1.41597110
49MP0003828_pulmonary_edema1.40081591
50* MP0002429_abnormal_blood_cell1.34916276
51MP0003806_abnormal_nucleotide_metabolis1.33212563
52MP0000920_abnormal_myelination1.32043728
53MP0002722_abnormal_immune_system1.31056428
54MP0006054_spinal_hemorrhage1.30376711
55MP0002166_altered_tumor_susceptibility1.29383122
56MP0009764_decreased_sensitivity_to1.28988860
57MP0002277_abnormal_respiratory_mucosa1.26771509
58MP0000858_altered_metastatic_potential1.25587096
59MP0009840_abnormal_foam_cell1.22458483
60MP0000604_amyloidosis1.19268958
61MP0003656_abnormal_erythrocyte_physiolo1.16355840
62MP0002933_joint_inflammation1.13691181
63MP0010307_abnormal_tumor_latency1.13064693
64MP0002332_abnormal_exercise_endurance1.11480066
65MP0009763_increased_sensitivity_to1.08848667
66MP0003763_abnormal_thymus_physiology1.07156444
67MP0004883_abnormal_blood_vessel1.05419746
68MP0003329_amyloid_beta_deposits1.00337139
69MP0000465_gastrointestinal_hemorrhage0.99368543
70MP0002396_abnormal_hematopoietic_system0.97436324
71MP0005164_abnormal_response_to0.97133452
72MP0003183_abnormal_peptide_metabolism0.95026906
73MP0005390_skeleton_phenotype0.94293037
74MP0001873_stomach_inflammation0.91219234
75MP0003045_fibrosis0.90842142
76MP0008260_abnormal_autophagy0.88900040
77MP0008004_abnormal_stomach_pH0.88831241
78MP0003195_calcinosis0.86708211
79MP0000015_abnormal_ear_pigmentation0.86269908
80MP0000249_abnormal_blood_vessel0.84810790
81MP0000703_abnormal_thymus_morphology0.84446603
82MP0004782_abnormal_surfactant_physiolog0.80028135
83MP0009765_abnormal_xenobiotic_induced0.78452651
84MP0003091_abnormal_cell_migration0.77954748
85MP0001545_abnormal_hematopoietic_system0.76260874
86MP0005397_hematopoietic_system_phenotyp0.76260874
87MP0002090_abnormal_vision0.75482955
88MP0005174_abnormal_tail_pigmentation0.75338615
89MP0003866_abnormal_defecation0.75318669
90MP0008873_increased_physiological_sensi0.74253873
91MP0001542_abnormal_bone_strength0.72810019
92MP0009278_abnormal_bone_marrow0.72663610
93MP0002877_abnormal_melanocyte_morpholog0.69720468
94MP0008874_decreased_physiological_sensi0.69045543
95MP0005647_abnormal_sex_gland0.68870681
96MP0000569_abnormal_digit_pigmentation0.66635634
97MP0000371_diluted_coat_color0.66534298
98MP0003795_abnormal_bone_structure0.64033095
99MP0003950_abnormal_plasma_membrane0.63692974
100MP0002132_abnormal_respiratory_system0.63675409
101MP0000490_abnormal_crypts_of0.62810027
102MP0002254_reproductive_system_inflammat0.59544876
103MP0002138_abnormal_hepatobiliary_system0.57843240
104MP0002136_abnormal_kidney_physiology0.56678044
105MP0001915_intracranial_hemorrhage0.55984821
106MP0003453_abnormal_keratinocyte_physiol0.54970333
107MP0000767_abnormal_smooth_muscle0.54431259
108MP0003566_abnormal_cell_adhesion0.53289440
109MP0000609_abnormal_liver_physiology0.52823561
110MP0005319_abnormal_enzyme/_coenzyme0.52422566
111MP0003646_muscle_fatigue0.50561224
112MP0002693_abnormal_pancreas_physiology0.49716670
113MP0005365_abnormal_bile_salt0.49360701
114MP0002928_abnormal_bile_duct0.48899047
115MP0005409_darkened_coat_color0.45145729
116MP0001663_abnormal_digestive_system0.45126890
117MP0003279_aneurysm0.44905861
118MP0008007_abnormal_cellular_replicative0.43748883
119MP0005257_abnormal_intraocular_pressure0.43015985
120MP0005165_increased_susceptibility_to0.42503128
121MP0004808_abnormal_hematopoietic_stem0.42108148

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.85963558
2Recurrent abscess formation (HP:0002722)6.97378628
3Recurrent bacterial skin infections (HP:0005406)6.27335145
4Eczematoid dermatitis (HP:0000976)5.86837715
5Glomerulonephritis (HP:0000099)5.83054241
6Abnormality of macrophages (HP:0004311)5.35171152
7Recurrent gram-negative bacterial infections (HP:0005420)4.99735572
8Increased cerebral lipofuscin (HP:0011813)4.51604739
9Myositis (HP:0100614)4.32226081
10Abnormality of glycolipid metabolism (HP:0010969)4.31902240
11Abnormality of liposaccharide metabolism (HP:0010968)4.31902240
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.31902240
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.31270737
14Vacuolated lymphocytes (HP:0001922)4.28445873
15Loss of speech (HP:0002371)4.14754555
16Complement deficiency (HP:0004431)4.03633519
17Recurrent skin infections (HP:0001581)4.00270543
18Optic neuritis (HP:0100653)3.93123923
19Retrobulbar optic neuritis (HP:0100654)3.93123923
20Orchitis (HP:0100796)3.85748761
21Mediastinal lymphadenopathy (HP:0100721)3.71060134
22Dysostosis multiplex (HP:0000943)3.65335238
23Obstructive lung disease (HP:0006536)3.65213742
24Chronic obstructive pulmonary disease (HP:0006510)3.65213742
25Abnormality of complement system (HP:0005339)3.50408291
26Recurrent fungal infections (HP:0002841)3.47995007
27Gingivitis (HP:0000230)3.33645494
28Elevated erythrocyte sedimentation rate (HP:0003565)3.29587935
29Axonal loss (HP:0003447)3.26222322
30Thick nail (HP:0001805)3.25153509
31Disinhibition (HP:0000734)3.19985036
32Stomatitis (HP:0010280)3.18927259
33Nephritis (HP:0000123)3.18896443
34Neurofibrillary tangles (HP:0002185)3.18682929
35Arterial tortuosity (HP:0005116)3.14796616
36Meningitis (HP:0001287)3.07417345
37Recurrent cutaneous fungal infections (HP:0011370)2.97152924
38Chronic mucocutaneous candidiasis (HP:0002728)2.97152924
39Pustule (HP:0200039)2.91638997
40Prostate neoplasm (HP:0100787)2.90015524
41Recurrent viral infections (HP:0004429)2.87613205
42Spontaneous hematomas (HP:0007420)2.82641490
43Hematochezia (HP:0002573)2.82377844
44Vasculitis (HP:0002633)2.78849672
45Chronic diarrhea (HP:0002028)2.78062650
46Encephalitis (HP:0002383)2.75664761
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.70497887
48Basal ganglia calcification (HP:0002135)2.69877218
49Vascular tortuosity (HP:0004948)2.69584720
50Mutism (HP:0002300)2.69265414
51Agnosia (HP:0010524)2.63899950
52Nuclear cataract (HP:0100018)2.63310083
53Mucopolysacchariduria (HP:0008155)2.56581595
54Urinary glycosaminoglycan excretion (HP:0003541)2.56581595
55Purpura (HP:0000979)2.54836825
56Apathy (HP:0000741)2.53183247
57Hepatosplenomegaly (HP:0001433)2.52002580
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51796498
59Gangrene (HP:0100758)2.51303345
60Periodontitis (HP:0000704)2.48872101
61Diminished motivation (HP:0000745)2.47599696
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47225012
63Gastrointestinal infarctions (HP:0005244)2.47172306
64Neuronal loss in central nervous system (HP:0002529)2.47167374
65Leukocytosis (HP:0001974)2.44776442
66Abnormality of polysaccharide metabolism (HP:0011012)2.43551893
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43551893
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43551893
69Colitis (HP:0002583)2.42883369
70Keratoconjunctivitis sicca (HP:0001097)2.42699633
71Pulmonary infiltrates (HP:0002113)2.41700502
72Eosinophilia (HP:0001880)2.40363046
73Amyloidosis (HP:0011034)2.39221785
74Inflammation of the large intestine (HP:0002037)2.38449919
75Polyneuropathy (HP:0001271)2.37242458
76Retinal atrophy (HP:0001105)2.36633898
77Progressive neurologic deterioration (HP:0002344)2.35226944
78Recurrent pneumonia (HP:0006532)2.35152071
79Arterial thrombosis (HP:0004420)2.34534699
80Hemoptysis (HP:0002105)2.31751538
81Increased CSF protein (HP:0002922)2.31676261
82Increased serum ferritin (HP:0003281)2.30333082
83Cerebral inclusion bodies (HP:0100314)2.30122483
84Prolonged bleeding time (HP:0003010)2.28614157
85Autoimmune thrombocytopenia (HP:0001973)2.27178284
86Progressive visual loss (HP:0000529)2.26266825
87Myocardial infarction (HP:0001658)2.24294038
88Cellulitis (HP:0100658)2.23298208
89Autoimmune hemolytic anemia (HP:0001890)2.21750604
90Hypoproteinemia (HP:0003075)2.20788783
91Keratoconjunctivitis (HP:0001096)2.20056026
92Upper motor neuron abnormality (HP:0002127)2.18932034
93Pulmonary embolism (HP:0002204)2.13750530
94Interstitial pulmonary disease (HP:0006530)2.11261598
95Cheilitis (HP:0100825)2.10342386
96Gastrointestinal inflammation (HP:0004386)2.08582914
97Hypergammaglobulinemia (HP:0010702)2.07885800
98Abnormality of eosinophils (HP:0001879)2.07406791
99Granulocytopenia (HP:0001913)2.07089156
100Osteomyelitis (HP:0002754)2.05899104
101Increased IgE level (HP:0003212)2.02304978
102IgM deficiency (HP:0002850)2.02208871
103Abnormality of the pleura (HP:0002103)2.02135809
104Anorexia (HP:0002039)2.01406789
105Metaphyseal irregularity (HP:0003025)2.01024619
106Urethral obstruction (HP:0000796)2.00728770
107Abnormality of iron homeostasis (HP:0011031)2.00253030
108Pathologic fracture (HP:0002756)1.99966486
109Chronic otitis media (HP:0000389)1.99447706
110Urticaria (HP:0001025)1.97513460
111Joint swelling (HP:0001386)1.97320650
112Personality changes (HP:0000751)1.97318597
113Joint hemorrhage (HP:0005261)1.97250392
114Malnutrition (HP:0004395)1.97126206
115Petechiae (HP:0000967)1.96192612
116Abnormality of the prostate (HP:0008775)1.96121234
117Gingival bleeding (HP:0000225)1.95070941
118Abnormality of T cell number (HP:0011839)1.94916355
119T lymphocytopenia (HP:0005403)1.94567561
120Increased IgM level (HP:0003496)1.93914606
121Memory impairment (HP:0002354)1.93331845
122Inappropriate behavior (HP:0000719)1.93104462
123Cerebral aneurysm (HP:0004944)1.93045393
124Global brain atrophy (HP:0002283)1.92235080
125Chest pain (HP:0100749)1.92200316
126Disproportionate tall stature (HP:0001519)1.91212924
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.90663037
128Glomerulopathy (HP:0100820)1.89100549
129Vertigo (HP:0002321)1.88949671
130Abnormality of T cells (HP:0002843)1.87238677
131Asymmetric septal hypertrophy (HP:0001670)1.87233708
132Premature loss of primary teeth (HP:0006323)1.85201064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.11768591
2TXK4.17567636
3BLK3.75664566
4TYK23.57873232
5RIPK43.37528819
6IRAK43.35695822
7IRAK33.05352913
8MAP3K142.93205605
9JAK12.84092062
10NME22.50025555
11MAPK152.48484854
12DDR22.41763698
13MAP4K12.38032008
14TBK12.30874174
15CSF1R2.25925830
16TAOK22.23108604
17RIPK11.97151989
18ITK1.84931112
19IKBKE1.84109927
20MAP3K111.82337084
21KIT1.80913286
22TAOK11.80024634
23IKBKB1.78807172
24CSK1.74366983
25MAP3K31.67192903
26ZAP701.56402229
27JAK31.51822693
28CDC42BPA1.51398117
29HCK1.51001347
30LYN1.49760760
31PBK1.46262323
32EPHB11.45224533
33LCK1.43403703
34BMPR21.42492021
35FES1.40311614
36FGR1.38216180
37CAMK1D1.37759499
38ACVR1B1.37031641
39SYK1.35349173
40NEK91.34384133
41STK101.24877481
42MAP3K131.17318945
43CLK11.16780002
44BTK1.16245067
45TYRO31.13566560
46TEC1.13108087
47SIK21.08856283
48TAOK31.07966697
49MAP3K11.07022293
50JAK21.03960162
51CAMK1G1.00649874
52YES11.00463317
53* GRK70.96248631
54PIM20.93493571
55TESK20.89631687
56SIK30.89110677
57IRAK10.87427352
58PIM10.84010843
59MATK0.83917436
60MAP3K50.83437874
61MARK30.82453760
62TRPM70.80965996
63ABL20.76358669
64EIF2AK20.75855357
65MST40.75837087
66CHUK0.74354297
67ERN10.73447956
68FGFR30.71584774
69IGF1R0.66462887
70PRPF4B0.65580002
71MAPK70.64727771
72MOS0.63578742
73MAPKAPK20.63310102
74PRKCQ0.61955591
75MAP2K60.59923067
76IRAK20.58651772
77MAPK120.58370136
78DAPK20.58144571
79EPHA30.57494634
80TNK20.57257031
81VRK10.55810870
82PRKCD0.55186960
83EGFR0.53875600
84ABL10.52929564
85CDK30.52538048
86PLK20.51772118
87RPS6KA40.51458023
88CAMKK20.51105261
89MAPKAPK50.50461716
90CDK60.48751302
91PDPK10.47045749
92PIK3CG0.45250185
93GSK3A0.44533311
94GRK50.43333428
95FYN0.43232323
96TESK10.42589870
97PDGFRA0.41841603
98SGK30.41634033
99MAPK40.41300995
100RPS6KC10.41085229
101RPS6KL10.41085229
102PKN10.40668760
103PAK40.40395524
104NUAK10.39965598
105INSR0.39387246
106FGFR40.39124233
107BMPR1B0.38716363
108HIPK20.38518881
109ARAF0.36080099
110KSR20.35392855
111PDK10.33324914
112RPS6KA50.33277302
113NEK60.32669886
114RPS6KA60.32333846
115GRK60.32304336
116TSSK60.30815527
117DYRK30.30019968
118TTN0.29457759
119BMX0.29021801
120STK40.28848564
121DMPK0.27698213
122MARK20.27475619
123MAP2K30.26899839
124CDK40.23539516
125CAMK40.23053732
126RPS6KA20.22919118
127CASK0.22317208
128PRKCH0.20523609
129PDGFRB0.20399777
130PRKG10.19466123
131SRC0.18243799

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.21315279
2Staphylococcus aureus infection_Homo sapiens_hsa051504.10525496
3Allograft rejection_Homo sapiens_hsa053303.27194296
4Leishmaniasis_Homo sapiens_hsa051402.86703157
5Osteoclast differentiation_Homo sapiens_hsa043802.56164586
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54993798
7Pertussis_Homo sapiens_hsa051332.43325938
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32931386
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.31101761
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31047812
11Other glycan degradation_Homo sapiens_hsa005112.28467824
12Autoimmune thyroid disease_Homo sapiens_hsa053202.23872941
13Type I diabetes mellitus_Homo sapiens_hsa049402.13050579
14Lysosome_Homo sapiens_hsa041422.09670558
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.97845234
16Tuberculosis_Homo sapiens_hsa051521.94318332
17Measles_Homo sapiens_hsa051621.91698921
18Rheumatoid arthritis_Homo sapiens_hsa053231.86719922
19Antigen processing and presentation_Homo sapiens_hsa046121.81373216
20Malaria_Homo sapiens_hsa051441.79429014
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.78556372
22B cell receptor signaling pathway_Homo sapiens_hsa046621.74455433
23Legionellosis_Homo sapiens_hsa051341.66704529
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64199853
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58532617
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.56703066
27Phagosome_Homo sapiens_hsa041451.54348689
28Hematopoietic cell lineage_Homo sapiens_hsa046401.45510291
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43160074
30* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41546504
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37828373
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37310081
33Influenza A_Homo sapiens_hsa051641.36637444
34Salmonella infection_Homo sapiens_hsa051321.36285524
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30868595
36* Chemokine signaling pathway_Homo sapiens_hsa040621.30091775
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.28686389
38* Toxoplasmosis_Homo sapiens_hsa051451.25828806
39Complement and coagulation cascades_Homo sapiens_hsa046101.24747226
40TNF signaling pathway_Homo sapiens_hsa046681.21397683
41Primary immunodeficiency_Homo sapiens_hsa053401.19809046
42Viral myocarditis_Homo sapiens_hsa054161.18404339
43Apoptosis_Homo sapiens_hsa042101.16659219
44Prion diseases_Homo sapiens_hsa050201.14188546
45T cell receptor signaling pathway_Homo sapiens_hsa046601.12401331
46Asthma_Homo sapiens_hsa053101.08550537
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03967265
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99006551
49Hepatitis B_Homo sapiens_hsa051610.97882635
50Herpes simplex infection_Homo sapiens_hsa051680.97844879
51Shigellosis_Homo sapiens_hsa051310.94250474
52African trypanosomiasis_Homo sapiens_hsa051430.91603786
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.91422902
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74509300
55Hepatitis C_Homo sapiens_hsa051600.73995056
56Pancreatic cancer_Homo sapiens_hsa052120.73105057
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.71711224
58Platelet activation_Homo sapiens_hsa046110.70283665
59Bladder cancer_Homo sapiens_hsa052190.68561648
60Sphingolipid metabolism_Homo sapiens_hsa006000.62729141
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60226889
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58716584
63Amoebiasis_Homo sapiens_hsa051460.57877101
64Ether lipid metabolism_Homo sapiens_hsa005650.57682694
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57453073
66Chronic myeloid leukemia_Homo sapiens_hsa052200.56819314
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56190609
68Collecting duct acid secretion_Homo sapiens_hsa049660.54334414
69* Endocytosis_Homo sapiens_hsa041440.53514884
70Acute myeloid leukemia_Homo sapiens_hsa052210.50273923
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.49792601
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49453838
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48066509
74Type II diabetes mellitus_Homo sapiens_hsa049300.47004653
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46099083
76Renal cell carcinoma_Homo sapiens_hsa052110.44607235
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44014756
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43416778
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.42291364
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40415016
81Epstein-Barr virus infection_Homo sapiens_hsa051690.37502969
82Prolactin signaling pathway_Homo sapiens_hsa049170.36010467
83Notch signaling pathway_Homo sapiens_hsa043300.35809547
84ABC transporters_Homo sapiens_hsa020100.34120273
85MAPK signaling pathway_Homo sapiens_hsa040100.29094916
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28116640
87HTLV-I infection_Homo sapiens_hsa051660.27664361
88Insulin resistance_Homo sapiens_hsa049310.26868047
89Colorectal cancer_Homo sapiens_hsa052100.25888579
90Galactose metabolism_Homo sapiens_hsa000520.24809659
91* Viral carcinogenesis_Homo sapiens_hsa052030.24363986
92PPAR signaling pathway_Homo sapiens_hsa033200.24047912
93VEGF signaling pathway_Homo sapiens_hsa043700.23833903
94Dorso-ventral axis formation_Homo sapiens_hsa043200.22333979
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21629906
96Systemic lupus erythematosus_Homo sapiens_hsa053220.21166990
97Mineral absorption_Homo sapiens_hsa049780.20754987
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19397256
99FoxO signaling pathway_Homo sapiens_hsa040680.19235465
100Rap1 signaling pathway_Homo sapiens_hsa040150.19021181
101Arachidonic acid metabolism_Homo sapiens_hsa005900.17882185
102GnRH signaling pathway_Homo sapiens_hsa049120.17711880
103Non-small cell lung cancer_Homo sapiens_hsa052230.17675853
104HIF-1 signaling pathway_Homo sapiens_hsa040660.16438247
105Renin secretion_Homo sapiens_hsa049240.16366725
106Ras signaling pathway_Homo sapiens_hsa040140.15547333
107Sulfur metabolism_Homo sapiens_hsa009200.14793072
108Adherens junction_Homo sapiens_hsa045200.14791729
109Caffeine metabolism_Homo sapiens_hsa002320.13694661
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13625766
111Renin-angiotensin system_Homo sapiens_hsa046140.13336179
112Inositol phosphate metabolism_Homo sapiens_hsa005620.13260823
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13009066
114Vibrio cholerae infection_Homo sapiens_hsa051100.11761488
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.11395698

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