CCR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.17199914
2response to interleukin-15 (GO:0070672)7.15734760
3antigen processing and presentation of endogenous antigen (GO:0019883)6.98206437
4cellular response to interleukin-15 (GO:0071350)6.88869241
5regulation of gamma-delta T cell differentiation (GO:0045586)6.27322377
6B cell receptor signaling pathway (GO:0050853)6.12308223
7positive thymic T cell selection (GO:0045059)5.98397587
8negative thymic T cell selection (GO:0045060)5.85722665
9regulation of gamma-delta T cell activation (GO:0046643)5.76503984
10negative T cell selection (GO:0043383)5.69394253
11tolerance induction (GO:0002507)5.58834077
12regulation of B cell receptor signaling pathway (GO:0050855)5.57310999
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.30043699
14negative regulation of cell killing (GO:0031342)5.22061746
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.22061746
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.19174299
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.19174299
18NIK/NF-kappaB signaling (GO:0038061)5.18347232
19thymic T cell selection (GO:0045061)5.14055353
20T cell selection (GO:0045058)4.77119238
21positive T cell selection (GO:0043368)4.77090563
22regulation of B cell differentiation (GO:0045577)4.65523346
23positive regulation of T cell differentiation in thymus (GO:0033089)4.50532617
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.42065995
25regulation of interleukin-2 biosynthetic process (GO:0045076)4.37424279
26mature B cell differentiation (GO:0002335)4.35792382
27T cell costimulation (GO:0031295)4.35186563
28regulation of T cell mediated cytotoxicity (GO:0001914)4.32740914
29cellular response to zinc ion (GO:0071294)4.29253250
30JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.28571498
31lymphocyte costimulation (GO:0031294)4.26797382
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.26456842
33lymph node development (GO:0048535)4.26200079
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22290471
35positive regulation of T cell mediated cytotoxicity (GO:0001916)4.21434264
36positive regulation of B cell differentiation (GO:0045579)4.20241658
37positive regulation of interleukin-2 production (GO:0032743)4.19896256
38regulation of interleukin-12 biosynthetic process (GO:0045075)4.15922826
39positive regulation of alpha-beta T cell proliferation (GO:0046641)4.15526438
40antigen receptor-mediated signaling pathway (GO:0050851)4.14400243
41germinal center formation (GO:0002467)4.10439517
42negative regulation of T cell mediated immunity (GO:0002710)3.96393403
43negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.94375049
44activated T cell proliferation (GO:0050798)3.93111147
45leukocyte aggregation (GO:0070486)3.89491524
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.85412279
47antigen processing and presentation via MHC class Ib (GO:0002475)3.84254406
48regulation of T cell tolerance induction (GO:0002664)3.81333002
49alpha-beta T cell differentiation (GO:0046632)3.79302226
50regulation of B cell proliferation (GO:0030888)3.79245507
51positive regulation of T cell cytokine production (GO:0002726)3.76656310
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.70585632
53positive regulation of T cell mediated immunity (GO:0002711)3.66926442
54negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.63921395
55regulation of alpha-beta T cell proliferation (GO:0046640)3.63885059
56negative regulation of interleukin-10 production (GO:0032693)3.63041506
57B cell proliferation (GO:0042100)3.61443199
58determination of adult lifespan (GO:0008340)3.59461154
59positive regulation of B cell proliferation (GO:0030890)3.56884658
60regulation of cell killing (GO:0031341)3.55378744
61mast cell activation (GO:0045576)3.52806473
62positive regulation of T-helper 1 type immune response (GO:0002827)3.52786707
63regulation of memory T cell differentiation (GO:0043380)3.51273658
64T cell receptor signaling pathway (GO:0050852)3.50865241
65regulation of immunoglobulin secretion (GO:0051023)3.50401422
66positive regulation of cell killing (GO:0031343)3.48125898
67T cell migration (GO:0072678)3.48110507
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.46084129
69regulation of T cell mediated immunity (GO:0002709)3.45424275
70T cell differentiation involved in immune response (GO:0002292)3.44703938
71alpha-beta T cell differentiation involved in immune response (GO:0002293)3.44703938
72alpha-beta T cell activation involved in immune response (GO:0002287)3.44703938
73T cell proliferation (GO:0042098)3.43825982
74positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.38996164
75lymphocyte homeostasis (GO:0002260)3.36719029
76positive regulation of defense response to virus by host (GO:0002230)3.35060425
77immune response-activating cell surface receptor signaling pathway (GO:0002429)3.33477154
78regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33448676
79positive regulation of natural killer cell mediated immunity (GO:0002717)3.32159192
80positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.32159192
81* dendritic cell chemotaxis (GO:0002407)3.32133213
82regulation of isotype switching to IgG isotypes (GO:0048302)3.31686581
83regulation of interleukin-2 production (GO:0032663)3.31156306
84T cell homeostasis (GO:0043029)3.31087574
85positive regulation of antigen processing and presentation (GO:0002579)3.30757255
86regulation of T-helper 1 type immune response (GO:0002825)3.30403974
87alpha-beta T cell activation (GO:0046631)3.29865670
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.28423313
89T-helper cell differentiation (GO:0042093)3.28423313
90myeloid dendritic cell differentiation (GO:0043011)3.25950950
91interferon-gamma production (GO:0032609)3.24154689
92myeloid dendritic cell activation (GO:0001773)3.23577249
93positive regulation of B cell activation (GO:0050871)3.21485307
94mature B cell differentiation involved in immune response (GO:0002313)3.20753957
95Peyers patch development (GO:0048541)3.20095950
96mucosal-associated lymphoid tissue development (GO:0048537)3.20095950
97negative regulation of leukocyte mediated immunity (GO:0002704)3.18302888
98regulation of T cell receptor signaling pathway (GO:0050856)3.18075590
99positive regulation of humoral immune response (GO:0002922)3.17880503
100lymphocyte proliferation (GO:0046651)3.17427393
101positive regulation of mRNA catabolic process (GO:0061014)3.16797322
102regulation of germinal center formation (GO:0002634)3.15700646
103negative regulation of B cell apoptotic process (GO:0002903)3.15367259
104mononuclear cell proliferation (GO:0032943)3.15133026
105interferon-gamma-mediated signaling pathway (GO:0060333)3.14989361
106positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.14871314
107positive regulation of natural killer cell differentiation (GO:0032825)3.14567979
108regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.14010245
109negative regulation of B cell proliferation (GO:0030889)3.13998569
110regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.12769700
111regulation of natural killer cell mediated immunity (GO:0002715)3.12769700
112positive regulation of alpha-beta T cell activation (GO:0046635)3.12670260
113defense response to protozoan (GO:0042832)3.12099198
114regulation of B cell activation (GO:0050864)3.12024878
115T cell differentiation (GO:0030217)3.11894398
116* dendritic cell migration (GO:0036336)3.10563030
117positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09896369
118regulation of alpha-beta T cell activation (GO:0046634)3.09394497
119regulation of T cell cytokine production (GO:0002724)3.09064491
120regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.08500625
121B cell homeostasis (GO:0001782)3.07727245
122positive regulation of lymphocyte mediated immunity (GO:0002708)3.07574855
123regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.06916180
124positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.06916180
125positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.05731642
126leukocyte proliferation (GO:0070661)3.05100489
127regulation of leukocyte mediated cytotoxicity (GO:0001910)3.04825615
128DNA deamination (GO:0045006)3.04133940
129positive regulation of DNA recombination (GO:0045911)3.02861402
130positive regulation of adaptive immune response (GO:0002821)2.99236518
131regulation of interleukin-12 production (GO:0032655)2.99166551
132positive regulation of interleukin-12 production (GO:0032735)2.97070896
133neutrophil activation (GO:0042119)2.97065595
134regulation of interferon-beta biosynthetic process (GO:0045357)2.95645408
135positive regulation of isotype switching (GO:0045830)2.94866546
136positive regulation of T cell differentiation (GO:0045582)2.93926837
137pericardium development (GO:0060039)2.93608468
138positive regulation of immunoglobulin production (GO:0002639)2.91962759
139cytidine metabolic process (GO:0046087)2.91174044
140cytidine catabolic process (GO:0006216)2.91174044
141cytidine deamination (GO:0009972)2.91174044
142CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.90782821
143response to protozoan (GO:0001562)2.89765604
144regulation of adaptive immune response based on somatic recombination of immune receptors built from2.88196127
145regulation of B cell apoptotic process (GO:0002902)2.88127357
146leukocyte homeostasis (GO:0001776)2.86926523
147regulation of regulatory T cell differentiation (GO:0045589)2.86794218
148positive regulation of tolerance induction (GO:0002645)2.85080424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.86761410
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.80247336
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.41588837
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.43519215
5MYC_22102868_ChIP-Seq_BL_Human4.33484681
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.58331514
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.44328410
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.29179487
9E2F7_22180533_ChIP-Seq_HELA_Human3.26013442
10RUNX_20019798_ChIP-Seq_JUKART_Human3.24038164
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.22099502
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19513863
13IRF8_21731497_ChIP-ChIP_J774_Mouse3.17561021
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.09515279
15MYB_26560356_Chip-Seq_TH2_Human2.98722399
16VDR_21846776_ChIP-Seq_THP-1_Human2.98235721
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97745636
18MYB_26560356_Chip-Seq_TH1_Human2.86480232
19MAF_26560356_Chip-Seq_TH1_Human2.84888898
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.71003992
21* IRF8_27001747_Chip-Seq_BMDM_Mouse2.65558199
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62338708
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.54162669
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49204389
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.46017576
26UTX_26944678_Chip-Seq_JUKART_Human2.43480132
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22484709
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10707438
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10278757
30* VDR_24763502_ChIP-Seq_THP-1_Human2.10065412
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09709559
32TCF7_22412390_ChIP-Seq_EML_Mouse2.05166187
33PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03004293
34MAF_26560356_Chip-Seq_TH2_Human2.02251523
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97191777
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94946905
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87276243
38GATA3_27048872_Chip-Seq_THYMUS_Human1.85963325
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83694822
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.83637764
41CIITA_25753668_ChIP-Seq_RAJI_Human1.82980981
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82809066
43SPI1_23547873_ChIP-Seq_NB4_Human1.79339440
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.78761225
45KDM2B_26808549_Chip-Seq_DND41_Human1.71070768
46ZNF274_21170338_ChIP-Seq_K562_Hela1.70988243
47SCL_19346495_ChIP-Seq_HPC-7_Human1.67876609
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66355011
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62861906
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62350092
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56527227
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52109313
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48810210
54SPI1_23127762_ChIP-Seq_K562_Human1.45313616
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45106334
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.41265690
57VDR_22108803_ChIP-Seq_LS180_Human1.36709290
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31375565
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28226671
60PU_27001747_Chip-Seq_BMDM_Mouse1.28092410
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27029480
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26157176
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.25832361
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.24826460
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.24338507
66GATA1_22025678_ChIP-Seq_K562_Human1.20925988
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20509093
68EZH2_22144423_ChIP-Seq_EOC_Human1.18650158
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18200551
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16374855
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15769512
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14790080
73GATA3_26560356_Chip-Seq_TH2_Human1.14273610
74RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13947579
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.13571644
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11823934
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09589009
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08568162
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07310793
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05641695
81ER_23166858_ChIP-Seq_MCF-7_Human1.02869171
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02031568
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98301398
84VDR_24787735_ChIP-Seq_THP-1_Human0.97495711
85KDM2B_26808549_Chip-Seq_JURKAT_Human0.96219157
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95791895
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95542970
88IRF1_19129219_ChIP-ChIP_H3396_Human0.95184551
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94852110
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94357801
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.93055459
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92328486
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91659155
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88833635
95* SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.88408109
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88055602
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.87932873
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86738415
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86227541
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86146581
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85803287
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85402442
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84732606
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84377464
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.83986351
106* LXR_22292898_ChIP-Seq_THP-1_Human0.82646317
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82540695
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81888950
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80535875
110VDR_23849224_ChIP-Seq_CD4+_Human0.80115964
111FOXP3_21729870_ChIP-Seq_TREG_Human0.79352326
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.79282585
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.79130931
114* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78272457
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78168420
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77945327
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77943919
118NCOR1_26117541_ChIP-Seq_K562_Human0.77714489
119P300_27268052_Chip-Seq_Bcells_Human0.76971048
120FOXA1_25329375_ChIP-Seq_VCAP_Human0.76439032
121FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76439032
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75956341
123SMRT_27268052_Chip-Seq_Bcells_Human0.75912741
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75298057
125CEBPB_22108803_ChIP-Seq_LS180_Human0.75181348
126TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75016917
127GATA3_26560356_Chip-Seq_TH1_Human0.74928044
128TAF15_26573619_Chip-Seq_HEK293_Human0.74923584
129BCL6_27268052_Chip-Seq_Bcells_Human0.74415537
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73308255
131BCAT_22108803_ChIP-Seq_LS180_Human0.72183227
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.70819876
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70686147
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.69774294
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69586104
136AR_20517297_ChIP-Seq_VCAP_Human0.69291449
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68724974
138EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.68685194
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67949313
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.67660185
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65237204
142* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.64244799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001790_abnormal_immune_system4.64945667
2MP0005387_immune_system_phenotype4.64945667
3* MP0001835_abnormal_antigen_presentation4.58039737
4MP0000685_abnormal_immune_system4.41792223
5* MP0001800_abnormal_humoral_immune4.28949819
6MP0005671_abnormal_response_to3.86919780
7MP0003763_abnormal_thymus_physiology3.74557183
8* MP0005000_abnormal_immune_tolerance3.33036872
9* MP0002452_abnormal_antigen_presenting3.26908890
10* MP0002723_abnormal_immune_serum3.07223273
11* MP0002420_abnormal_adaptive_immunity2.95906627
12* MP0001819_abnormal_immune_cell2.87672715
13MP0001873_stomach_inflammation2.84711839
14* MP0002398_abnormal_bone_marrow2.75289373
15MP0003303_peritoneal_inflammation2.64424632
16MP0004510_myositis2.54830803
17* MP0000716_abnormal_immune_system2.54116822
18MP0002405_respiratory_system_inflammati2.42450087
19MP0009785_altered_susceptibility_to2.35086922
20MP0000689_abnormal_spleen_morphology2.34810421
21MP0010155_abnormal_intestine_physiology2.21660222
22MP0002166_altered_tumor_susceptibility2.21513522
23MP0003300_gastrointestinal_ulcer2.20728606
24* MP0005025_abnormal_response_to2.17686626
25* MP0002722_abnormal_immune_system2.14944196
26MP0003436_decreased_susceptibility_to2.12933355
27MP0003866_abnormal_defecation2.08844324
28MP0002933_joint_inflammation2.05621504
29MP0000703_abnormal_thymus_morphology2.03624542
30* MP0002429_abnormal_blood_cell2.03446689
31MP0010352_gastrointestinal_tract_polyps1.96145497
32* MP0002148_abnormal_hypersensitivity_rea1.94306121
33MP0002396_abnormal_hematopoietic_system1.94136013
34* MP0002419_abnormal_innate_immunity1.91161492
35MP0009333_abnormal_splenocyte_physiolog1.83432773
36MP0001853_heart_inflammation1.79765494
37* MP0001845_abnormal_inflammatory_respons1.76739058
38MP0002254_reproductive_system_inflammat1.75810144
39MP0005310_abnormal_salivary_gland1.75808514
40MP0004947_skin_inflammation1.69610679
41MP0005075_abnormal_melanosome_morpholog1.69442052
42MP0004381_abnormal_hair_follicle1.69084424
43MP0002006_tumorigenesis1.59667371
44MP0003252_abnormal_bile_duct1.58030863
45MP0003183_abnormal_peptide_metabolism1.56172784
46MP0008057_abnormal_DNA_replication1.36780279
47MP0006082_CNS_inflammation1.34457031
48MP0003195_calcinosis1.23138614
49MP0005464_abnormal_platelet_physiology1.21301085
50MP0003011_delayed_dark_adaptation1.16826721
51MP0002138_abnormal_hepatobiliary_system1.16145444
52MP0002876_abnormal_thyroid_physiology1.11585392
53MP0004808_abnormal_hematopoietic_stem1.11389064
54MP0001919_abnormal_reproductive_system1.10608731
55MP0002163_abnormal_gland_morphology1.07912060
56MP0003724_increased_susceptibility_to1.07374706
57MP0008469_abnormal_protein_level1.04897851
58MP0008961_abnormal_basal_metabolism1.04107143
59MP0004885_abnormal_endolymph1.03109888
60MP0008872_abnormal_physiological_respon1.03024758
61MP0000465_gastrointestinal_hemorrhage1.02333573
62MP0001348_abnormal_lacrimal_gland1.01788406
63MP0005076_abnormal_cell_differentiation0.96623211
64MP0002909_abnormal_adrenal_gland0.96162389
65MP0003045_fibrosis0.94381121
66MP0005167_abnormal_blood-brain_barrier0.91647335
67MP0001765_abnormal_ion_homeostasis0.88371415
68MP0008877_abnormal_DNA_methylation0.85487028
69MP0008875_abnormal_xenobiotic_pharmacok0.85051566
70MP0002019_abnormal_tumor_incidence0.84473836
71MP0004264_abnormal_extraembryonic_tissu0.84103955
72MP0003453_abnormal_keratinocyte_physiol0.83179262
73MP0002277_abnormal_respiratory_mucosa0.81317290
74MP0002136_abnormal_kidney_physiology0.80885423
75MP0003091_abnormal_cell_migration0.80459941
76MP0010234_abnormal_vibrissa_follicle0.80446802
77MP0003329_amyloid_beta_deposits0.79739499
78MP0005645_abnormal_hypothalamus_physiol0.78733990
79MP0010329_abnormal_lipoprotein_level0.77798531
80MP0009764_decreased_sensitivity_to0.76990437
81MP0003448_altered_tumor_morphology0.74928202
82MP0001881_abnormal_mammary_gland0.74666645
83MP0002928_abnormal_bile_duct0.74303730
84MP0001533_abnormal_skeleton_physiology0.74203350
85MP0005379_endocrine/exocrine_gland_phen0.74007158
86MP0000858_altered_metastatic_potential0.73743771
87MP0000490_abnormal_crypts_of0.73186584
88MP0002009_preneoplasia0.73038431
89MP0003828_pulmonary_edema0.71960242
90MP0003638_abnormal_response/metabolism_0.70781942
91MP0006072_abnormal_retinal_apoptosis0.70565226
92MP0001851_eye_inflammation0.70418501
93MP0003878_abnormal_ear_physiology0.68830389
94MP0005377_hearing/vestibular/ear_phenot0.68830389
95MP0005360_urolithiasis0.67754557
96MP0005390_skeleton_phenotype0.66789194
97MP0000427_abnormal_hair_cycle0.66128635
98MP0003077_abnormal_cell_cycle0.65401133
99MP0005084_abnormal_gallbladder_morpholo0.64853308
100MP0000372_irregular_coat_pigmentation0.64560772
101MP0005365_abnormal_bile_salt0.63729860
102MP0001663_abnormal_digestive_system0.62875961
103MP0004130_abnormal_muscle_cell0.62426236
104MP0004147_increased_porphyrin_level0.62118056
105MP0000249_abnormal_blood_vessel0.62063423
106MP0005389_reproductive_system_phenotype0.61507007
107MP0004742_abnormal_vestibular_system0.60290598
108MP0003646_muscle_fatigue0.60233102
109MP0000609_abnormal_liver_physiology0.59233685
110MP0001986_abnormal_taste_sensitivity0.57958323
111MP0000569_abnormal_digit_pigmentation0.57902244
112MP0005253_abnormal_eye_physiology0.57806065
113MP0010094_abnormal_chromosome_stability0.57533074
114MP0005174_abnormal_tail_pigmentation0.56056560
115MP0009763_increased_sensitivity_to0.55902604
116MP0003959_abnormal_lean_body0.55816491
117MP0002877_abnormal_melanocyte_morpholog0.53299402
118MP0001501_abnormal_sleep_pattern0.50855749
119MP0009765_abnormal_xenobiotic_induced0.49917097
120MP0000604_amyloidosis0.49799207
121MP0005023_abnormal_wound_healing0.49041400
122MP0008874_decreased_physiological_sensi0.48550055
123MP0000350_abnormal_cell_proliferation0.48491126
124MP0002693_abnormal_pancreas_physiology0.48289938
125MP0000477_abnormal_intestine_morphology0.44509158
126MP0002998_abnormal_bone_remodeling0.43842781
127MP0000003_abnormal_adipose_tissue0.43184255
128MP0005621_abnormal_cell_physiology0.43159504
129MP0000313_abnormal_cell_death0.42320989
130MP0000367_abnormal_coat/_hair0.41696368
131MP0003787_abnormal_imprinting0.41421734
132MP0001191_abnormal_skin_condition0.41293354
133MP0005397_hematopoietic_system_phenotyp0.40986039
134MP0001545_abnormal_hematopoietic_system0.40986039
135MP0005451_abnormal_body_composition0.40331575
136MP0000371_diluted_coat_color0.39237642
137MP0001216_abnormal_epidermal_layer0.36218345
138MP0008058_abnormal_DNA_repair0.36199867

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.79491963
2Gastrointestinal stroma tumor (HP:0100723)6.43806480
3Recurrent bronchitis (HP:0002837)5.81927852
4Recurrent cutaneous fungal infections (HP:0011370)5.65659202
5Chronic mucocutaneous candidiasis (HP:0002728)5.65659202
6IgM deficiency (HP:0002850)5.54684108
7Abnormal delayed hypersensitivity skin test (HP:0002963)5.39174561
8Panhypogammaglobulinemia (HP:0003139)5.23057957
9Recurrent sinusitis (HP:0011108)5.11665818
10Colitis (HP:0002583)5.00253339
11Recurrent fungal infections (HP:0002841)4.95624641
12Inflammation of the large intestine (HP:0002037)4.86908974
13Increased IgM level (HP:0003496)4.68517563
14Recurrent viral infections (HP:0004429)4.65860104
15Gastrointestinal inflammation (HP:0004386)4.64826887
16Lymphopenia (HP:0001888)4.42072534
17Eczematoid dermatitis (HP:0000976)4.34174308
18Chronic diarrhea (HP:0002028)4.24562719
19IgA deficiency (HP:0002720)4.22155516
20Abnormality of cells of the lymphoid lineage (HP:0012140)4.21127128
21T lymphocytopenia (HP:0005403)4.19385883
22Meningitis (HP:0001287)4.19379523
23Vasculitis (HP:0002633)4.15036336
24Cellulitis (HP:0100658)4.13935227
25Emphysema (HP:0002097)4.12277723
26Abnormality of T cell number (HP:0011839)4.06712871
27Abnormality of T cells (HP:0002843)4.01620625
28Myositis (HP:0100614)3.84848089
29Recurrent skin infections (HP:0001581)3.74811842
30Chronic otitis media (HP:0000389)3.73020119
31Abnormality of T cell physiology (HP:0011840)3.71263120
32Papilloma (HP:0012740)3.70517034
33Verrucae (HP:0200043)3.70517034
34IgG deficiency (HP:0004315)3.60497812
35Retrobulbar optic neuritis (HP:0100654)3.58749408
36Optic neuritis (HP:0100653)3.58749408
37Increased density of long bones (HP:0006392)3.40961285
38Mediastinal lymphadenopathy (HP:0100721)3.38484934
39B lymphocytopenia (HP:0010976)3.31798110
40Abnormality of B cell number (HP:0010975)3.31798110
41Recurrent abscess formation (HP:0002722)3.27711749
42Thyroiditis (HP:0100646)3.26214346
43Stomach cancer (HP:0012126)3.26122547
44Bronchitis (HP:0012387)3.24476161
45Recurrent bacterial skin infections (HP:0005406)3.19695017
46Restrictive lung disease (HP:0002091)3.14705643
47Gastrointestinal infarctions (HP:0005244)3.12860523
48Osteomyelitis (HP:0002754)3.07672761
49Orchitis (HP:0100796)3.07398286
50Abnormality of the fingertips (HP:0001211)3.04998126
51Keratoconjunctivitis (HP:0001096)3.02407930
52Interstitial pulmonary disease (HP:0006530)3.01659258
53Chronic sinusitis (HP:0011109)3.00301158
54Severe combined immunodeficiency (HP:0004430)2.99995412
55Encephalitis (HP:0002383)2.96694290
56Recurrent otitis media (HP:0000403)2.95529733
57Combined immunodeficiency (HP:0005387)2.89056299
58Lymphoma (HP:0002665)2.88437991
59Persistence of primary teeth (HP:0006335)2.88272689
60Recurrent lower respiratory tract infections (HP:0002783)2.87715365
61Recurrent pneumonia (HP:0006532)2.86143768
62Abnormality of the prostate (HP:0008775)2.82052888
63* Pulmonary infiltrates (HP:0002113)2.79770585
64Nasal polyposis (HP:0100582)2.69319784
65Pustule (HP:0200039)2.66802548
66Increased IgE level (HP:0003212)2.65906527
67Hemoptysis (HP:0002105)2.65894101
68Leukopenia (HP:0001882)2.65553262
69Elevated erythrocyte sedimentation rate (HP:0003565)2.65295504
70Abnormality of the renal cortex (HP:0011035)2.64386968
71Keratoconjunctivitis sicca (HP:0001097)2.62890319
72Viral hepatitis (HP:0006562)2.59113456
73Renal cortical cysts (HP:0000803)2.55508375
74Thrombocytosis (HP:0001894)2.53369680
75Spontaneous hematomas (HP:0007420)2.50070205
76Stomatitis (HP:0010280)2.49518587
77Vertebral arch anomaly (HP:0008438)2.49092461
78Gangrene (HP:0100758)2.47743701
79Abnormality of eosinophils (HP:0001879)2.47362571
80Chronic obstructive pulmonary disease (HP:0006510)2.45527988
81Obstructive lung disease (HP:0006536)2.45527988
82Arterial thrombosis (HP:0004420)2.40792541
83Metabolic alkalosis (HP:0200114)2.34193802
84Supernumerary bones of the axial skeleton (HP:0009144)2.32252109
85Prostate neoplasm (HP:0100787)2.30899814
86Hepatitis (HP:0012115)2.27757647
87Sepsis (HP:0100806)2.23799222
88Abnormality of the pleura (HP:0002103)2.19454049
89Papilledema (HP:0001085)2.17468052
90Hypochromic anemia (HP:0001931)2.16547003
91Mitral stenosis (HP:0001718)2.16470688
92Hypoproteinemia (HP:0003075)2.15846928
93Hypergammaglobulinemia (HP:0010702)2.15364626
94Abnormality of the nasal mucosa (HP:0000433)2.14069624
95Eosinophilia (HP:0001880)2.10928082
96Congenital stationary night blindness (HP:0007642)2.10648645
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10475168
98Villous atrophy (HP:0011473)2.09911821
99Abnormality of small intestinal villus morphology (HP:0011472)2.09911821
100* Arthralgia (HP:0002829)2.09662591
101Leukocytosis (HP:0001974)2.08695201
102Joint swelling (HP:0001386)2.06810810
103Anorexia (HP:0002039)2.06675971
104Recurrent gram-negative bacterial infections (HP:0005420)2.06299371
105Supernumerary ribs (HP:0005815)2.05757067
106Premature loss of primary teeth (HP:0006323)2.03793878
107Hypoplasia of the thymus (HP:0000778)2.02656833
108Hypokalemic alkalosis (HP:0001949)1.99960108
109Abnormality of the endocardium (HP:0004306)1.99891835
110Cheilitis (HP:0100825)1.99507352
111Glomerulopathy (HP:0100820)1.99385587
112Hematochezia (HP:0002573)1.98453148
113Abnormality of macrophages (HP:0004311)1.97272133
114* Skin ulcer (HP:0200042)1.96673196
115Pulmonary embolism (HP:0002204)1.93980600
116Skin rash (HP:0000988)1.93607378
117Gingivitis (HP:0000230)1.93486606
118Polyneuropathy (HP:0001271)1.93399322
119Attenuation of retinal blood vessels (HP:0007843)1.90112600
120Alveolar cell carcinoma (HP:0006519)1.88959142
1213-Methylglutaconic aciduria (HP:0003535)1.88218052
122Small epiphyses (HP:0010585)1.86991633
123Neutropenia (HP:0001875)1.85646459
124Autoimmune thrombocytopenia (HP:0001973)1.85498010
125Short tibia (HP:0005736)1.85141760
126Keratitis (HP:0000491)1.84531424
127Granulocytopenia (HP:0001913)1.84287532
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.83016972
129Autoimmune hemolytic anemia (HP:0001890)1.81452754
130Conical tooth (HP:0000698)1.78999422
131Chest pain (HP:0100749)1.77392660
132Resting tremor (HP:0002322)1.75809364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.90146566
2MAP3K143.52593195
3JAK33.03490447
4TXK2.88389855
5JAK12.76088004
6GRK62.54039651
7TYK22.41003389
8MAP2K22.34445711
9MAP3K132.34250186
10SYK2.33610944
11ITK2.24357294
12BTK2.20284097
13STK102.10608833
14FGFR42.07577203
15IRAK32.04958375
16CSF1R2.04265300
17SIK22.01244504
18SIK31.93611764
19LRRK21.93351069
20ZAP701.93021473
21CDK121.85687287
22EPHA31.84821610
23BLK1.78548720
24EEF2K1.77692181
25TEC1.72626941
26NLK1.70994143
27TLK11.68811164
28ERN11.59293317
29HCK1.59097155
30TBK11.56520053
31MAPKAPK31.53698605
32IKBKB1.52860963
33ADRBK21.52224216
34IKBKE1.50249722
35IRAK41.45166920
36TAOK31.42642514
37FGFR31.41026248
38EPHB11.39554854
39BMPR21.37774022
40LCK1.36580592
41KIT1.33320232
42GRK51.30794739
43CHUK1.30512909
44RIPK41.28236973
45PRKCQ1.27508935
46CAMKK21.25968401
47ZAK1.22586632
48FRK1.15763538
49LYN1.15287582
50CSK1.15197768
51MARK31.13570072
52MAP3K101.07215103
53ALK1.01228343
54PIM11.01190599
55SIK11.00928950
56PRKCH1.00842623
57MAP3K70.97838105
58MST40.95653790
59NUAK10.92986270
60CLK10.90152257
61CAMKK10.86758540
62BRD40.85923247
63PASK0.81476675
64MAP2K60.81404539
65FES0.80645670
66JAK20.79478228
67RPS6KA40.77364232
68MELK0.75482233
69TRPM70.74912466
70TGFBR20.69888625
71WNK40.69565262
72CDK40.67295870
73TRIB30.65633343
74TSSK60.62369041
75MAPK110.62111914
76HIPK20.61762665
77GRK70.60612455
78TESK20.60545714
79TNK20.58906732
80PTK60.53960032
81MAP2K10.53905694
82BCKDK0.53378629
83MAP4K20.52739088
84ADRBK10.51230344
85GRK10.50677902
86SCYL20.49021612
87INSR0.48576829
88MATK0.46170831
89PINK10.46160280
90CDC42BPA0.45975912
91DAPK10.45709041
92PIK3CA0.44516026
93CDK80.44315055
94PDK10.43285990
95OXSR10.41579639
96PRKCI0.39907828
97ACVR1B0.39729288
98ABL10.38857122
99EIF2AK20.38522229
100MAP3K10.37623165
101FYN0.37476633
102CDK90.36909518
103EIF2AK30.36418087
104PAK30.35681986
105ERBB30.32973637
106TTN0.31790084
107MUSK0.31551374
108MAP3K120.30402879
109EGFR0.30014048
110MAPKAPK20.29788706
111STK390.29763968
112PDGFRB0.27766385
113IRAK10.27179781
114PRKCD0.26457896
115IGF1R0.26263025
116FGR0.26244281
117KDR0.25785427
118PIK3CG0.24658881
119PKN20.24311559
120TRIM280.24284897
121RPS6KA50.22531824
122MAPK30.20688523
123STK110.20622269
124MAP3K80.20315086
125SGK30.19067086
126MAP2K30.18623682
127MARK20.18535037
128CAMK1G0.18514837
129NEK20.18101729
130CDK60.17653992
131FLT30.16878841
132PRKD20.16697590
133CHEK10.16294809
134CCNB10.16015227
135RAF10.15123045
136MAPK70.15107899
137MAPK150.13650559

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.39056915
2B cell receptor signaling pathway_Homo sapiens_hsa046624.45122287
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.70888326
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.44971391
5T cell receptor signaling pathway_Homo sapiens_hsa046603.01646681
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.88713220
7Hematopoietic cell lineage_Homo sapiens_hsa046402.77607955
8Antigen processing and presentation_Homo sapiens_hsa046122.64279048
9Osteoclast differentiation_Homo sapiens_hsa043802.56536639
10Measles_Homo sapiens_hsa051622.29475030
11Leishmaniasis_Homo sapiens_hsa051402.16354169
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15623515
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.93619296
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63401132
15* Chemokine signaling pathway_Homo sapiens_hsa040621.55159005
16Herpes simplex infection_Homo sapiens_hsa051681.49499563
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40168136
18Viral myocarditis_Homo sapiens_hsa054161.38951200
19Toxoplasmosis_Homo sapiens_hsa051451.37044005
20* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36113102
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35487346
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34515180
23Hepatitis B_Homo sapiens_hsa051611.31401360
24Caffeine metabolism_Homo sapiens_hsa002321.30353932
25Epstein-Barr virus infection_Homo sapiens_hsa051691.27870724
26Acute myeloid leukemia_Homo sapiens_hsa052211.22509207
27Chronic myeloid leukemia_Homo sapiens_hsa052201.22144418
28HTLV-I infection_Homo sapiens_hsa051661.18721684
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17467338
30Pancreatic cancer_Homo sapiens_hsa052121.16939352
31Tuberculosis_Homo sapiens_hsa051521.16344283
32Apoptosis_Homo sapiens_hsa042101.15583976
33TNF signaling pathway_Homo sapiens_hsa046681.14537996
34Influenza A_Homo sapiens_hsa051641.13326935
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.12551774
36Allograft rejection_Homo sapiens_hsa053301.12004674
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11252403
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02918163
39Prolactin signaling pathway_Homo sapiens_hsa049170.99916158
40Base excision repair_Homo sapiens_hsa034100.94284059
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93934514
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93386138
43Asthma_Homo sapiens_hsa053100.92850574
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92732558
45Viral carcinogenesis_Homo sapiens_hsa052030.91845789
46Shigellosis_Homo sapiens_hsa051310.89340910
47Legionellosis_Homo sapiens_hsa051340.87781947
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87727877
49Nitrogen metabolism_Homo sapiens_hsa009100.87324284
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.85357057
51Linoleic acid metabolism_Homo sapiens_hsa005910.85040486
52Autoimmune thyroid disease_Homo sapiens_hsa053200.84399282
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83157314
54VEGF signaling pathway_Homo sapiens_hsa043700.80086676
55Graft-versus-host disease_Homo sapiens_hsa053320.76711590
56Regulation of autophagy_Homo sapiens_hsa041400.75537675
57Non-small cell lung cancer_Homo sapiens_hsa052230.74389102
58MAPK signaling pathway_Homo sapiens_hsa040100.71906249
59Malaria_Homo sapiens_hsa051440.71444204
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.70842565
61Non-homologous end-joining_Homo sapiens_hsa034500.70644615
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69690468
63Platelet activation_Homo sapiens_hsa046110.69579358
64Hepatitis C_Homo sapiens_hsa051600.66659062
65Phototransduction_Homo sapiens_hsa047440.66484854
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65214533
67Dorso-ventral axis formation_Homo sapiens_hsa043200.64666363
68Type I diabetes mellitus_Homo sapiens_hsa049400.63419169
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62818543
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61679642
71Small cell lung cancer_Homo sapiens_hsa052220.60405291
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59890752
73p53 signaling pathway_Homo sapiens_hsa041150.59682827
74Peroxisome_Homo sapiens_hsa041460.59487659
75RNA polymerase_Homo sapiens_hsa030200.58866569
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58158460
77Colorectal cancer_Homo sapiens_hsa052100.54630023
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54200010
79Pertussis_Homo sapiens_hsa051330.53169613
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.51826401
81African trypanosomiasis_Homo sapiens_hsa051430.50677091
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.49834973
83Rheumatoid arthritis_Homo sapiens_hsa053230.49608520
84Endocytosis_Homo sapiens_hsa041440.48654488
85Arachidonic acid metabolism_Homo sapiens_hsa005900.47635442
86Renal cell carcinoma_Homo sapiens_hsa052110.47022490
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.46948936
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46845225
89Notch signaling pathway_Homo sapiens_hsa043300.46339175
90Salmonella infection_Homo sapiens_hsa051320.46207990
91MicroRNAs in cancer_Homo sapiens_hsa052060.45909960
92FoxO signaling pathway_Homo sapiens_hsa040680.45418899
93Insulin resistance_Homo sapiens_hsa049310.41700727
94Staphylococcus aureus infection_Homo sapiens_hsa051500.40114083
95Inositol phosphate metabolism_Homo sapiens_hsa005620.39890626
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39385158
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39303176
98Systemic lupus erythematosus_Homo sapiens_hsa053220.38740928
99Morphine addiction_Homo sapiens_hsa050320.38725452
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38433598
101Spliceosome_Homo sapiens_hsa030400.37973494
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36472413
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36258304
104DNA replication_Homo sapiens_hsa030300.35445388
105Tryptophan metabolism_Homo sapiens_hsa003800.35359134
106HIF-1 signaling pathway_Homo sapiens_hsa040660.35334965
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35235421
108Mismatch repair_Homo sapiens_hsa034300.35081298
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34375365
110Fat digestion and absorption_Homo sapiens_hsa049750.33048888
111Lysine degradation_Homo sapiens_hsa003100.32438554
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30994172
113Glycerolipid metabolism_Homo sapiens_hsa005610.30844687
114RNA degradation_Homo sapiens_hsa030180.30828966
115Fatty acid biosynthesis_Homo sapiens_hsa000610.29972191
116Ether lipid metabolism_Homo sapiens_hsa005650.29424444
117Pathways in cancer_Homo sapiens_hsa052000.28973798
118Vitamin digestion and absorption_Homo sapiens_hsa049770.28555202
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28409982
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.25454836
121Circadian rhythm_Homo sapiens_hsa047100.24885644
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24749444
123Prostate cancer_Homo sapiens_hsa052150.23712015
124mTOR signaling pathway_Homo sapiens_hsa041500.23467583
125Retinol metabolism_Homo sapiens_hsa008300.23423583
126Choline metabolism in cancer_Homo sapiens_hsa052310.23187785
127Proteoglycans in cancer_Homo sapiens_hsa052050.21707936
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19114576
129mRNA surveillance pathway_Homo sapiens_hsa030150.17292688
130Renin-angiotensin system_Homo sapiens_hsa046140.16987770
131ABC transporters_Homo sapiens_hsa020100.16437208
132One carbon pool by folate_Homo sapiens_hsa006700.16393036
133Glioma_Homo sapiens_hsa052140.15986284
134Chemical carcinogenesis_Homo sapiens_hsa052040.15944290
135Type II diabetes mellitus_Homo sapiens_hsa049300.15805684
136Basal transcription factors_Homo sapiens_hsa030220.15781225
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.14373967
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.13910981

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