CCR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)7.81873606
2antigen processing and presentation of endogenous antigen (GO:0019883)6.73008729
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.28288930
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.28288930
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.64280365
6regulation of T cell tolerance induction (GO:0002664)5.58843226
7regulation of T-helper 1 cell differentiation (GO:0045625)5.56183787
8regulation of activation of Janus kinase activity (GO:0010533)5.19770744
9regulation of interleukin-12 biosynthetic process (GO:0045075)5.16297349
10positive regulation of natural killer cell differentiation (GO:0032825)5.14484426
11regulation of alpha-beta T cell proliferation (GO:0046640)5.06451564
12regulation of RIG-I signaling pathway (GO:0039535)5.05986094
13myeloid dendritic cell differentiation (GO:0043011)5.02035603
14positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.95473253
15positive regulation of alpha-beta T cell proliferation (GO:0046641)4.90944570
16positive regulation of T-helper cell differentiation (GO:0045624)4.86420968
17positive regulation of interleukin-2 production (GO:0032743)4.75038938
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66104154
19positive regulation of gamma-delta T cell activation (GO:0046645)4.65079212
20cellular response to type I interferon (GO:0071357)4.63467265
21type I interferon signaling pathway (GO:0060337)4.63467265
22response to type I interferon (GO:0034340)4.59559849
23myeloid dendritic cell activation (GO:0001773)4.58159446
24* negative thymic T cell selection (GO:0045060)4.49034337
25regulation of T-helper 2 cell differentiation (GO:0045628)4.45986030
26regulation of memory T cell differentiation (GO:0043380)4.36351174
27* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35848773
28growth hormone receptor signaling pathway (GO:0060396)4.35678705
29* negative T cell selection (GO:0043383)4.31751445
30T-helper 1 type immune response (GO:0042088)4.30544833
31regulation of B cell receptor signaling pathway (GO:0050855)4.29214451
32negative regulation of T cell mediated immunity (GO:0002710)4.29108033
33positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.27388634
34regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.24232696
35regulation of T-helper cell differentiation (GO:0045622)4.23986426
36regulation of tolerance induction (GO:0002643)4.23302835
37neutrophil activation involved in immune response (GO:0002283)4.23198385
38regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.22419587
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.18158554
40positive regulation of type 2 immune response (GO:0002830)4.16197001
41natural killer cell mediated cytotoxicity (GO:0042267)4.16072909
42natural killer cell mediated immunity (GO:0002228)4.16072909
43* positive regulation of interleukin-12 production (GO:0032735)4.12813837
44neutrophil activation (GO:0042119)4.10842781
45negative regulation of interleukin-12 production (GO:0032695)4.07858329
46tolerance induction (GO:0002507)4.06710756
47T-helper cell differentiation (GO:0042093)4.01689137
48CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.01689137
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.97805638
50interferon-gamma-mediated signaling pathway (GO:0060333)3.95224375
51positive regulation of T cell cytokine production (GO:0002726)3.94657406
52regulation of immunoglobulin secretion (GO:0051023)3.93235940
53T cell migration (GO:0072678)3.91778373
54granulocyte activation (GO:0036230)3.89294304
55cellular response to zinc ion (GO:0071294)3.89000673
56natural killer cell activation (GO:0030101)3.87815706
57CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.87694119
58natural killer cell differentiation (GO:0001779)3.82320893
59regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.79158544
60immunoglobulin mediated immune response (GO:0016064)3.77978489
61positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.77703365
62regulation of chronic inflammatory response (GO:0002676)3.77138058
63defense response to protozoan (GO:0042832)3.76506008
64cellular response to growth hormone stimulus (GO:0071378)3.73222853
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72673760
66negative regulation of cell killing (GO:0031342)3.72673760
67regulation of MHC class I biosynthetic process (GO:0045343)3.72346053
68response to muramyl dipeptide (GO:0032495)3.65092378
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.64768773
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.63951030
71modulation by symbiont of host immune response (GO:0052553)3.63951030
72positive regulation by symbiont of host defense response (GO:0052509)3.63951030
73modulation by symbiont of host defense response (GO:0052031)3.63951030
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.63951030
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.63951030
76T cell costimulation (GO:0031295)3.61916499
77positive regulation of activated T cell proliferation (GO:0042104)3.60941892
78positive thymic T cell selection (GO:0045059)3.59889212
79cellular response to interleukin-15 (GO:0071350)3.59791828
80natural killer cell activation involved in immune response (GO:0002323)3.59487323
81positive regulation of interleukin-17 production (GO:0032740)3.58111123
82negative regulation of lymphocyte mediated immunity (GO:0002707)3.57100857
83regulation of gamma-delta T cell differentiation (GO:0045586)3.56963756
84response to interleukin-15 (GO:0070672)3.56742449
85lymphocyte costimulation (GO:0031294)3.54493846
86positive regulation of interferon-alpha production (GO:0032727)3.54434811
87T cell differentiation involved in immune response (GO:0002292)3.53835439
88alpha-beta T cell differentiation involved in immune response (GO:0002293)3.53835439
89alpha-beta T cell activation involved in immune response (GO:0002287)3.53835439
90response to protozoan (GO:0001562)3.52620771
91regulation of type I interferon-mediated signaling pathway (GO:0060338)3.52265614
92regulation of T-helper 1 type immune response (GO:0002825)3.52087172
93* T cell selection (GO:0045058)3.51998593
94regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.46339317
95regulation of interferon-beta biosynthetic process (GO:0045357)3.45847546
96positive regulation of tolerance induction (GO:0002645)3.45597889
97regulation of regulatory T cell differentiation (GO:0045589)3.45433983
98positive regulation of isotype switching (GO:0045830)3.45087403
99B cell proliferation (GO:0042100)3.44927333
100cellular response to interferon-beta (GO:0035458)3.44256240
101* thymic T cell selection (GO:0045061)3.40571494
102positive regulation of alpha-beta T cell differentiation (GO:0046638)3.38904276
103regulation of natural killer cell differentiation (GO:0032823)3.37775062
104regulation of gamma-delta T cell activation (GO:0046643)3.36929767
105leukocyte aggregation (GO:0070486)3.36151882
106regulation of natural killer cell mediated immunity (GO:0002715)3.35883645
107regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.35883645
108negative regulation of viral genome replication (GO:0045071)3.34605982
109interferon-gamma production (GO:0032609)3.32899629
110positive regulation of T-helper 1 type immune response (GO:0002827)3.32733241
111regulation of interferon-alpha production (GO:0032647)3.31729975
112macrophage activation involved in immune response (GO:0002281)3.31521096
113regulation of T cell mediated cytotoxicity (GO:0001914)3.30614078
114positive regulation of defense response to virus by host (GO:0002230)3.29605890
115* regulation of interleukin-12 production (GO:0032655)3.28189173
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28042005
117detection of bacterium (GO:0016045)3.26266193
118positive regulation of protein homooligomerization (GO:0032464)3.25548923
119T cell activation involved in immune response (GO:0002286)3.25100260
120antigen processing and presentation via MHC class Ib (GO:0002475)3.24630591
121regulation of type 2 immune response (GO:0002828)3.24508047
122B cell receptor signaling pathway (GO:0050853)3.24179424
123sequestering of actin monomers (GO:0042989)3.22274139
124detection of other organism (GO:0098543)3.20969060
125negative regulation of cytokine production involved in immune response (GO:0002719)3.20183213
126positive regulation of T cell proliferation (GO:0042102)3.19960498
127regulation of interleukin-2 production (GO:0032663)3.19932832
128* regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19370985
129germinal center formation (GO:0002467)3.18742527
130regulation of alpha-beta T cell differentiation (GO:0046637)3.18721052
131B cell mediated immunity (GO:0019724)3.18474595
132alpha-beta T cell activation (GO:0046631)3.18007754
133* dendritic cell differentiation (GO:0097028)3.17603020
134negative regulation of leukocyte mediated immunity (GO:0002704)3.16921579
135regulation of response to interferon-gamma (GO:0060330)3.15742781
136positive regulation of natural killer cell mediated immunity (GO:0002717)3.15596347
137positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.15596347
138regulation of alpha-beta T cell activation (GO:0046634)3.14119511
139positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.12469487
140regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.12469487
141regulation of necroptotic process (GO:0060544)3.11874571
142regulation of isotype switching to IgG isotypes (GO:0048302)3.11742093
143cellular response to interferon-gamma (GO:0071346)3.10189475
144negative regulation of type 2 immune response (GO:0002829)3.08813228
145negative regulation of innate immune response (GO:0045824)3.07057379
146positive T cell selection (GO:0043368)3.06551173
147positive regulation of B cell mediated immunity (GO:0002714)3.04141248
148positive regulation of immunoglobulin mediated immune response (GO:0002891)3.04141248
149response to peptidoglycan (GO:0032494)3.04140228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.72217762
2* FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.24967739
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.75347270
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.63598107
5IRF8_21731497_ChIP-ChIP_J774_Mouse5.55269604
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.80524752
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.71714548
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.42492392
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.37462515
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.34553549
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.23812343
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.06707367
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96207183
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85829587
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76102486
16RUNX_20019798_ChIP-Seq_JUKART_Human2.72856868
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.61628730
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59538147
19* MYB_26560356_Chip-Seq_TH2_Human2.57192585
20* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56329823
21* MAF_26560356_Chip-Seq_TH1_Human2.54321072
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.44190685
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29136309
24* MYB_26560356_Chip-Seq_TH1_Human2.19944480
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.16758702
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.04331324
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92475255
28* SPI1_23547873_ChIP-Seq_NB4_Human1.82227525
29VDR_21846776_ChIP-Seq_THP-1_Human1.77845032
30MYC_22102868_ChIP-Seq_BL_Human1.77546770
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69368638
32MAF_26560356_Chip-Seq_TH2_Human1.66387635
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.66270961
34* GATA3_27048872_Chip-Seq_THYMUS_Human1.65851764
35VDR_24763502_ChIP-Seq_THP-1_Human1.65198959
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60279815
37VDR_24787735_ChIP-Seq_THP-1_Human1.58317024
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57015345
39UTX_26944678_Chip-Seq_JUKART_Human1.52500099
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51347287
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45157684
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45043829
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42431257
44TCF7_22412390_ChIP-Seq_EML_Mouse1.42398336
45GATA3_26560356_Chip-Seq_TH2_Human1.41715570
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.41521354
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41352542
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38097609
49* PU_27001747_Chip-Seq_BMDM_Mouse1.38041137
50SPI1_23127762_ChIP-Seq_K562_Human1.37431625
51CIITA_25753668_ChIP-Seq_RAJI_Human1.36277512
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32233460
53GATA1_22025678_ChIP-Seq_K562_Human1.30930152
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28858889
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27684710
56KDM2B_26808549_Chip-Seq_DND41_Human1.22332387
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21485134
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18661815
59* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16603279
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13447152
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09529669
62SCL_19346495_ChIP-Seq_HPC-7_Human1.08757729
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08609237
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07344360
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05621596
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01370049
67SMRT_27268052_Chip-Seq_Bcells_Human0.99980065
68ELK3_25401928_ChIP-Seq_HUVEC_Human0.98689030
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98190051
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96288378
71EGR1_19032775_ChIP-ChIP_M12_Human0.95117042
72* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94588178
73* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94473651
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94029984
75BCL6_27268052_Chip-Seq_Bcells_Human0.93113007
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92247728
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91927990
78* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91592148
79* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89985951
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88079899
81BCOR_27268052_Chip-Seq_Bcells_Human0.85989203
82* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85152775
83* LXR_22292898_ChIP-Seq_THP-1_Human0.83410554
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81508052
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80617270
86GATA1_19941826_ChIP-Seq_K562_Human0.79262944
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.79182572
88TFEB_21752829_ChIP-Seq_HELA_Human0.77024504
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.75842312
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75321650
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73522749
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73367095
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.73008977
94* NCOR1_26117541_ChIP-Seq_K562_Human0.72245802
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71997553
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71960694
97VDR_23849224_ChIP-Seq_CD4+_Human0.70406782
98ZNF263_19887448_ChIP-Seq_K562_Human0.69489038
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69393873
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68975058
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.67804996
102ELF1_17652178_ChIP-ChIP_JURKAT_Human0.67658676
103SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.66170182
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65288912
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.63146238
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.57875544
107CTCF_26484167_Chip-Seq_Bcells_Mouse0.57100640
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.56640809
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.56640809
110* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.55733169
111P300_27268052_Chip-Seq_Bcells_Human0.54800611
112RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.54130719
113KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.53479381
114CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53161798
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.52867384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.62196320
2MP0000685_abnormal_immune_system4.85806711
3MP0002138_abnormal_hepatobiliary_system4.81874077
4MP0004510_myositis3.87460778
5MP0005387_immune_system_phenotype3.79112971
6MP0001790_abnormal_immune_system3.79112971
7MP0005671_abnormal_response_to3.66756396
8MP0009785_altered_susceptibility_to3.39813749
9MP0002166_altered_tumor_susceptibility3.32405049
10* MP0002148_abnormal_hypersensitivity_rea3.24858146
11* MP0001800_abnormal_humoral_immune3.03272079
12* MP0005000_abnormal_immune_tolerance3.02580907
13MP0003436_decreased_susceptibility_to2.93061738
14MP0002254_reproductive_system_inflammat2.91738642
15MP0003763_abnormal_thymus_physiology2.85705011
16MP0002006_tumorigenesis2.82216020
17* MP0002723_abnormal_immune_serum2.74887796
18* MP0002452_abnormal_antigen_presenting2.71625304
19MP0005025_abnormal_response_to2.63304475
20* MP0001819_abnormal_immune_cell2.55798777
21* MP0002420_abnormal_adaptive_immunity2.52481426
22MP0002419_abnormal_innate_immunity2.19812671
23* MP0002398_abnormal_bone_marrow2.17640069
24* MP0000716_abnormal_immune_system2.12300408
25MP0002405_respiratory_system_inflammati2.03700820
26MP0002009_preneoplasia2.02911689
27MP0001873_stomach_inflammation1.98250602
28MP0006082_CNS_inflammation1.96543222
29MP0001853_heart_inflammation1.95492219
30* MP0005310_abnormal_salivary_gland1.91029238
31* MP0001348_abnormal_lacrimal_gland1.86230853
32MP0010155_abnormal_intestine_physiology1.78576777
33MP0004947_skin_inflammation1.78002937
34MP0003303_peritoneal_inflammation1.68754088
35MP0005451_abnormal_body_composition1.67249934
36MP0008057_abnormal_DNA_replication1.65858746
37MP0009333_abnormal_splenocyte_physiolog1.65256044
38* MP0002429_abnormal_blood_cell1.64811085
39* MP0002722_abnormal_immune_system1.57019381
40* MP0001845_abnormal_inflammatory_respons1.56296863
41MP0002277_abnormal_respiratory_mucosa1.56063071
42* MP0000689_abnormal_spleen_morphology1.49733453
43MP0003724_increased_susceptibility_to1.48053010
44* MP0000703_abnormal_thymus_morphology1.33784981
45MP0008469_abnormal_protein_level1.29965215
46MP0000569_abnormal_digit_pigmentation1.29187488
47MP0003448_altered_tumor_morphology1.25596971
48MP0002877_abnormal_melanocyte_morpholog1.21204842
49MP0009764_decreased_sensitivity_to1.20729703
50MP0005464_abnormal_platelet_physiology1.20122288
51MP0002396_abnormal_hematopoietic_system1.19148237
52* MP0002163_abnormal_gland_morphology1.15837473
53MP0001533_abnormal_skeleton_physiology1.15059504
54MP0004381_abnormal_hair_follicle1.14282035
55MP0005076_abnormal_cell_differentiation1.12763182
56MP0003866_abnormal_defecation1.10160409
57MP0000858_altered_metastatic_potential1.07588941
58MP0000465_gastrointestinal_hemorrhage1.06211372
59MP0001545_abnormal_hematopoietic_system1.06170224
60MP0005397_hematopoietic_system_phenotyp1.06170224
61MP0003300_gastrointestinal_ulcer1.05697740
62MP0010352_gastrointestinal_tract_polyps1.00985641
63MP0004808_abnormal_hematopoietic_stem0.98374589
64MP0003453_abnormal_keratinocyte_physiol0.93761611
65MP0002933_joint_inflammation0.92656244
66MP0003191_abnormal_cellular_cholesterol0.92403436
67MP0009840_abnormal_foam_cell0.89785785
68MP0003075_altered_response_to0.87313747
69MP0005075_abnormal_melanosome_morpholog0.82909099
70MP0001881_abnormal_mammary_gland0.80486245
71MP0002876_abnormal_thyroid_physiology0.78526418
72MP0005166_decreased_susceptibility_to0.77646167
73MP0008004_abnormal_stomach_pH0.76961061
74MP0001851_eye_inflammation0.75701060
75MP0002998_abnormal_bone_remodeling0.75604994
76MP0003690_abnormal_glial_cell0.73126843
77MP0008260_abnormal_autophagy0.72660448
78MP0009763_increased_sensitivity_to0.72430696
79* MP0003091_abnormal_cell_migration0.69531286
80MP0000343_altered_response_to0.69037061
81MP0002019_abnormal_tumor_incidence0.67718434
82MP0003183_abnormal_peptide_metabolism0.66471078
83MP0005174_abnormal_tail_pigmentation0.66151800
84MP0000627_abnormal_mammary_gland0.65882906
85MP0008874_decreased_physiological_sensi0.63719349
86MP0002332_abnormal_exercise_endurance0.63376694
87MP0002693_abnormal_pancreas_physiology0.63058073
88MP0000604_amyloidosis0.59662073
89MP0010307_abnormal_tumor_latency0.59577190
90MP0009278_abnormal_bone_marrow0.58705918
91MP0000249_abnormal_blood_vessel0.57510176
92MP0000490_abnormal_crypts_of0.56691555
93MP0005167_abnormal_blood-brain_barrier0.56660434
94MP0009765_abnormal_xenobiotic_induced0.55635639
95MP0002132_abnormal_respiratory_system0.55369849
96MP0002928_abnormal_bile_duct0.54529198
97MP0002136_abnormal_kidney_physiology0.53922331
98MP0003795_abnormal_bone_structure0.53246492
99MP0005058_abnormal_lysosome_morphology0.53221825
100MP0004883_abnormal_blood_vessel0.53129669
101MP0003045_fibrosis0.52589871
102MP0003806_abnormal_nucleotide_metabolis0.51742495
103MP0003656_abnormal_erythrocyte_physiolo0.51432393
104MP0008961_abnormal_basal_metabolism0.50424769
105MP0000371_diluted_coat_color0.49155774
106* MP0001346_abnormal_lacrimal_gland0.49152964
107MP0005381_digestive/alimentary_phenotyp0.49095945
108MP0002139_abnormal_hepatobiliary_system0.47316508
109MP0003566_abnormal_cell_adhesion0.46451298
110MP0003172_abnormal_lysosome_physiology0.46237548
111MP0003646_muscle_fatigue0.45694174
112MP0005623_abnormal_meninges_morphology0.45436516
113MP0005164_abnormal_response_to0.45237779
114MP0000767_abnormal_smooth_muscle0.44127095
115MP0003221_abnormal_cardiomyocyte_apopto0.43872179
116MP0001243_abnormal_dermal_layer0.43482752
117MP0000609_abnormal_liver_physiology0.43337597
118MP0005390_skeleton_phenotype0.43020460
119MP0001663_abnormal_digestive_system0.36845837
120MP0001216_abnormal_epidermal_layer0.36436131
121MP0003943_abnormal_hepatobiliary_system0.35545498
122MP0000313_abnormal_cell_death0.35227893
123MP0009115_abnormal_fat_cell0.34794331
124MP0004782_abnormal_surfactant_physiolog0.34705234
125MP0000367_abnormal_coat/_hair0.33536312

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.98294470
2Chronic otitis media (HP:0000389)5.37394456
3Autoimmune thrombocytopenia (HP:0001973)5.24717664
4Eczematoid dermatitis (HP:0000976)5.24058004
5Abnormality of T cell number (HP:0011839)5.17372694
6Elevated erythrocyte sedimentation rate (HP:0003565)5.17350944
7Recurrent fungal infections (HP:0002841)5.08395202
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.91201583
9Gastrointestinal infarctions (HP:0005244)4.80232922
10Recurrent viral infections (HP:0004429)4.79637699
11Optic neuritis (HP:0100653)4.68496302
12Retrobulbar optic neuritis (HP:0100654)4.68496302
13Myositis (HP:0100614)4.58064777
14Nasal polyposis (HP:0100582)4.35955743
15Recurrent bacterial skin infections (HP:0005406)4.33234685
16Orchitis (HP:0100796)4.31922184
17Vasculitis (HP:0002633)4.25974076
18Recurrent abscess formation (HP:0002722)4.23382757
19T lymphocytopenia (HP:0005403)4.18876266
20Hypergammaglobulinemia (HP:0010702)4.16912788
21Recurrent bronchitis (HP:0002837)4.12369021
22Chronic mucocutaneous candidiasis (HP:0002728)4.09724651
23Recurrent cutaneous fungal infections (HP:0011370)4.09724651
24Eosinophilia (HP:0001880)4.08848948
25Autoimmune hemolytic anemia (HP:0001890)3.87451539
26Mediastinal lymphadenopathy (HP:0100721)3.85657154
27Abnormality of T cells (HP:0002843)3.74488231
28Agammaglobulinemia (HP:0004432)3.65837528
29Pulmonary infiltrates (HP:0002113)3.63869870
30Abnormality of the nasal mucosa (HP:0000433)3.63099563
31Granulocytopenia (HP:0001913)3.61878763
32Abnormality of eosinophils (HP:0001879)3.60893645
33Recurrent skin infections (HP:0001581)3.55546442
34Leukocytosis (HP:0001974)3.46293094
35IgG deficiency (HP:0004315)3.37286753
36Panhypogammaglobulinemia (HP:0003139)3.35268931
37Abnormality of the fingertips (HP:0001211)3.33224609
38Thrombocytosis (HP:0001894)3.30972287
39Arterial thrombosis (HP:0004420)3.26028886
40Abnormality of macrophages (HP:0004311)3.24179883
41Chronic sinusitis (HP:0011109)3.23857888
42Abnormality of T cell physiology (HP:0011840)3.23181409
43Increased IgE level (HP:0003212)3.23007277
44Fatigue (HP:0012378)3.13368544
45Chronic diarrhea (HP:0002028)3.10777624
46Joint swelling (HP:0001386)3.07336807
47Abnormality of cells of the lymphoid lineage (HP:0012140)3.05678003
48Hypochromic anemia (HP:0001931)3.05388989
49IgM deficiency (HP:0002850)3.04895305
50Hemoptysis (HP:0002105)3.04461116
51Severe combined immunodeficiency (HP:0004430)3.03773878
52Meningitis (HP:0001287)2.94032022
53Basal ganglia calcification (HP:0002135)2.84110880
54Stomatitis (HP:0010280)2.83253951
55Combined immunodeficiency (HP:0005387)2.82025544
56Recurrent gram-negative bacterial infections (HP:0005420)2.81185696
57Abnormality of B cell number (HP:0010975)2.80242365
58Keratoconjunctivitis sicca (HP:0001097)2.79601117
59Encephalitis (HP:0002383)2.79076707
60Colitis (HP:0002583)2.76599712
61IgA deficiency (HP:0002720)2.75346356
62Inflammation of the large intestine (HP:0002037)2.75050816
63Gingival bleeding (HP:0000225)2.71376709
64Periodontitis (HP:0000704)2.70696569
65Lymphopenia (HP:0001888)2.67915721
66Thyroiditis (HP:0100646)2.67604031
67Chest pain (HP:0100749)2.65014953
68Gastrointestinal inflammation (HP:0004386)2.61140136
69Cellulitis (HP:0100658)2.61129650
70Keratoconjunctivitis (HP:0001096)2.60453687
71B lymphocytopenia (HP:0010976)2.59527333
72Abnormality of the pleura (HP:0002103)2.53842444
73Gingivitis (HP:0000230)2.53086342
74Myocardial infarction (HP:0001658)2.50956095
75Porencephaly (HP:0002132)2.47704375
76Amaurosis fugax (HP:0100576)2.45735449
77Lymphoma (HP:0002665)2.45387262
78Restrictive lung disease (HP:0002091)2.44990739
79Pustule (HP:0200039)2.44208351
80Obstructive lung disease (HP:0006536)2.40523221
81Chronic obstructive pulmonary disease (HP:0006510)2.40523221
82Tetraparesis (HP:0002273)2.37946458
83Hypertensive crisis (HP:0100735)2.34326961
84Pulmonary embolism (HP:0002204)2.32619985
85Emphysema (HP:0002097)2.31506356
86Interstitial pulmonary disease (HP:0006530)2.31314827
87Anorexia (HP:0002039)2.29664201
88Spontaneous hematomas (HP:0007420)2.28781713
89Neutropenia (HP:0001875)2.26017278
90Loss of speech (HP:0002371)2.24261933
91Abnormality of liposaccharide metabolism (HP:0010968)2.23859076
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.23859076
93Abnormality of glycolipid metabolism (HP:0010969)2.23859076
94Bronchitis (HP:0012387)2.23767086
95Polyneuropathy (HP:0001271)2.21445976
96Peritonitis (HP:0002586)2.18787163
97Papilloma (HP:0012740)2.18300417
98Verrucae (HP:0200043)2.18300417
99Anhidrosis (HP:0000970)2.16706810
100Sepsis (HP:0100806)2.13126829
101Keratitis (HP:0000491)2.10639098
102Urticaria (HP:0001025)2.10204331
103Arthralgia (HP:0002829)2.08706668
104Glomerulopathy (HP:0100820)2.08131369
105Premature loss of primary teeth (HP:0006323)2.04574141
106Gangrene (HP:0100758)2.04539448
107Cerebral ischemia (HP:0002637)2.04161421
108Gastrointestinal stroma tumor (HP:0100723)2.03622329
109Abnormality of the prostate (HP:0008775)2.03578171
110Skin ulcer (HP:0200042)2.03547829
111Polycythemia (HP:0001901)2.03113946
112Abnormality of the endocardium (HP:0004306)1.99843574
113Acute hepatic failure (HP:0006554)1.99371760
114Osteolytic defects of the hand bones (HP:0009699)1.98435299
115Osteolytic defects of the phalanges of the hand (HP:0009771)1.98435299
116Recurrent pneumonia (HP:0006532)1.97731469
117Recurrent sinusitis (HP:0011108)1.97374803
118Viral hepatitis (HP:0006562)1.97091817
119Hematochezia (HP:0002573)1.96388414
120Osteomyelitis (HP:0002754)1.94127188
121Petechiae (HP:0000967)1.93554064
122Recurrent lower respiratory tract infections (HP:0002783)1.93489445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.03196496
2TYK24.23002388
3JAK33.90400354
4MAP3K133.72779494
5IKBKB3.65774509
6IKBKE3.35606384
7TBK13.32665806
8PRPF4B3.13443809
9MAP4K13.07232473
10CHUK2.93128296
11JAK12.84892621
12FGFR42.70004520
13EPHB12.26152583
14IRAK42.25458555
15TXK2.22732894
16EPHA31.96711287
17PASK1.92854214
18FGFR31.75782394
19PIM21.71833785
20ZAP701.70254545
21NLK1.69461958
22BLK1.61627799
23SYK1.53023796
24KIT1.52471259
25GRK71.49154223
26MST41.44014386
27BCR1.43136820
28ERN11.42174013
29TAOK21.40208544
30MATK1.34707434
31PIM11.33017785
32RIPK41.26088271
33LCK1.24434126
34GRK61.24410013
35BTK1.22427403
36BMPR21.20307973
37PKN11.17062064
38ITK1.16499996
39CSK1.15425875
40JAK21.13645732
41TNK21.13550654
42FLT31.11573976
43CSF1R1.05973257
44HCK1.05972920
45CAMKK11.03843496
46TEC1.03047171
47SMG10.99385866
48RPS6KA40.98624024
49SIK30.98416482
50PRKCQ0.97022951
51MAP3K110.95840392
52IRAK10.94652185
53STK100.93358036
54ARAF0.90941894
55CDC42BPA0.90119380
56TAOK10.89108967
57IRAK30.87256442
58NEK90.81293218
59TAOK30.80753276
60LRRK20.79442954
61SIK20.77847325
62MAP3K100.76999153
63MAP3K30.75714658
64STK40.75633609
65STK240.75519487
66CAMKK20.71344400
67CLK10.71318732
68PTK60.69011930
69CDK120.67520937
70MAPKAPK20.66332376
71RIPK10.65600610
72TESK10.65039668
73EIF2AK20.64180953
74RPS6KA50.64154345
75TYRO30.62575450
76LYN0.62259404
77PDK10.61246306
78MAPK70.51067558
79TGFBR20.50851870
80PRKAA20.48406319
81PRKCD0.48121400
82MARK30.48038896
83RPS6KA10.46647878
84NME20.46248475
85MAP2K60.45636034
86MELK0.43623220
87ADRBK20.43591190
88MAP3K50.41330475
89TESK20.40623918
90RAF10.40430056
91RET0.40218626
92ABL10.39601692
93FYN0.37080303
94BMX0.36055845
95EGFR0.34655740
96MAPK120.34611610
97MAPK40.34043789
98KDR0.33548072
99FES0.33394385
100DDR20.32988321
101HIPK20.32872977
102IRAK20.31680738
103TRIB30.31494711
104MAP3K10.31322758
105ALK0.29548669
106NUAK10.29351210
107MARK20.29209393
108ACVR1B0.29138682
109BRD40.26448865
110SIK10.23994912
111MAP2K30.23976107
112MAP2K20.22596449
113PDPK10.22429660
114INSR0.21730290
115DMPK0.21622058
116TLK10.21048700
117MOS0.20388651
118MAP3K70.19906376
119MAP3K80.19681463
120MAP3K90.19620674
121DYRK1B0.19370873
122WNK10.16210473
123TRPM70.15934294
124AKT10.15266555
125ABL20.15222724
126CDK60.14336924
127CDK40.13642239
128RPS6KA60.13398672
129MAPK30.13373068
130PDGFRB0.12850988
131STK30.12634111
132FGR0.12573647
133CDK90.12240633
134MAPK110.12023664

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.64289861
2Graft-versus-host disease_Homo sapiens_hsa053323.74106064
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.39631827
4NF-kappa B signaling pathway_Homo sapiens_hsa040643.12836929
5Autoimmune thyroid disease_Homo sapiens_hsa053203.11596965
6Primary immunodeficiency_Homo sapiens_hsa053402.92632428
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92095168
8Measles_Homo sapiens_hsa051622.76959197
9Type I diabetes mellitus_Homo sapiens_hsa049402.62732163
10Leishmaniasis_Homo sapiens_hsa051402.48076829
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.38115564
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33980181
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31610782
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18737862
15TNF signaling pathway_Homo sapiens_hsa046682.00143174
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99062701
17Osteoclast differentiation_Homo sapiens_hsa043801.97519226
18Viral myocarditis_Homo sapiens_hsa054161.93894133
19T cell receptor signaling pathway_Homo sapiens_hsa046601.92801322
20Antigen processing and presentation_Homo sapiens_hsa046121.92094914
21Toxoplasmosis_Homo sapiens_hsa051451.90065847
22Herpes simplex infection_Homo sapiens_hsa051681.89390120
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.88379304
24Influenza A_Homo sapiens_hsa051641.83424434
25B cell receptor signaling pathway_Homo sapiens_hsa046621.70918466
26Apoptosis_Homo sapiens_hsa042101.65802205
27* Chemokine signaling pathway_Homo sapiens_hsa040621.54602143
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47066487
29Legionellosis_Homo sapiens_hsa051341.42571331
30African trypanosomiasis_Homo sapiens_hsa051431.34870639
31* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33347159
32Shigellosis_Homo sapiens_hsa051311.29667931
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27326428
34Hepatitis B_Homo sapiens_hsa051611.27108311
35Pertussis_Homo sapiens_hsa051331.21516529
36Acute myeloid leukemia_Homo sapiens_hsa052211.21139302
37Prolactin signaling pathway_Homo sapiens_hsa049171.20539369
38Tuberculosis_Homo sapiens_hsa051521.17708808
39Rheumatoid arthritis_Homo sapiens_hsa053231.12371615
40Hepatitis C_Homo sapiens_hsa051601.07330481
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03977410
42Hematopoietic cell lineage_Homo sapiens_hsa046401.03764882
43Asthma_Homo sapiens_hsa053101.02749297
44Epstein-Barr virus infection_Homo sapiens_hsa051690.99258940
45Malaria_Homo sapiens_hsa051440.99015595
46Chronic myeloid leukemia_Homo sapiens_hsa052200.88243389
47Other glycan degradation_Homo sapiens_hsa005110.85402633
48Small cell lung cancer_Homo sapiens_hsa052220.83183571
49Viral carcinogenesis_Homo sapiens_hsa052030.81696965
50Salmonella infection_Homo sapiens_hsa051320.80408404
51p53 signaling pathway_Homo sapiens_hsa041150.79358348
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76588615
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.73307960
54HTLV-I infection_Homo sapiens_hsa051660.71483580
55Pancreatic cancer_Homo sapiens_hsa052120.70971507
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67741020
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66509031
58* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65706168
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65494140
60Staphylococcus aureus infection_Homo sapiens_hsa051500.65254052
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.63746346
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63482875
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.59340449
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58796086
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56194242
66MAPK signaling pathway_Homo sapiens_hsa040100.45260686
67VEGF signaling pathway_Homo sapiens_hsa043700.44607347
68Platelet activation_Homo sapiens_hsa046110.42599875
69Systemic lupus erythematosus_Homo sapiens_hsa053220.41594917
70Proteasome_Homo sapiens_hsa030500.39969400
71FoxO signaling pathway_Homo sapiens_hsa040680.36440528
72Phenylalanine metabolism_Homo sapiens_hsa003600.35499720
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34794527
74Insulin resistance_Homo sapiens_hsa049310.31648312
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31296327
76Type II diabetes mellitus_Homo sapiens_hsa049300.30413469
77MicroRNAs in cancer_Homo sapiens_hsa052060.30260348
78Non-small cell lung cancer_Homo sapiens_hsa052230.30175451
79Prostate cancer_Homo sapiens_hsa052150.28518755
80HIF-1 signaling pathway_Homo sapiens_hsa040660.26534919
81Renal cell carcinoma_Homo sapiens_hsa052110.25839758
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25722473
83Amoebiasis_Homo sapiens_hsa051460.25657418
84Notch signaling pathway_Homo sapiens_hsa043300.25312344
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24191314
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21994833
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.21283595
88Pathways in cancer_Homo sapiens_hsa052000.21163918
89Inositol phosphate metabolism_Homo sapiens_hsa005620.20034669
90Regulation of autophagy_Homo sapiens_hsa041400.19081583
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18817808
92Colorectal cancer_Homo sapiens_hsa052100.18383322
93Endometrial cancer_Homo sapiens_hsa052130.17916585
94mTOR signaling pathway_Homo sapiens_hsa041500.17342954
95Proteoglycans in cancer_Homo sapiens_hsa052050.16826805
96Endocytosis_Homo sapiens_hsa041440.16091418
97ErbB signaling pathway_Homo sapiens_hsa040120.15831771
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15306676
99Phagosome_Homo sapiens_hsa041450.14728431
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.13335077
101Prion diseases_Homo sapiens_hsa050200.13334454
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12893960
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.12363388
104Dorso-ventral axis formation_Homo sapiens_hsa043200.12329732
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11340822
106Lysosome_Homo sapiens_hsa041420.09672270
107Ras signaling pathway_Homo sapiens_hsa040140.09647882
108Adherens junction_Homo sapiens_hsa045200.09585309
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08491549
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08049529
111One carbon pool by folate_Homo sapiens_hsa006700.07747350
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07518008
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07254654
114Choline metabolism in cancer_Homo sapiens_hsa052310.05500340
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05086926
116Bladder cancer_Homo sapiens_hsa052190.04146166

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