CCR9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)8.87300334
2negative regulation of thymocyte apoptotic process (GO:0070244)8.82593734
3NIK/NF-kappaB signaling (GO:0038061)8.34200333
4negative T cell selection (GO:0043383)8.23929707
5regulation of gamma-delta T cell differentiation (GO:0045586)7.92688680
6positive regulation of gamma-delta T cell activation (GO:0046645)7.79602289
7activated T cell proliferation (GO:0050798)7.45048427
8regulation of protein polyubiquitination (GO:1902914)7.39867378
9T cell selection (GO:0045058)7.38011145
10regulation of gamma-delta T cell activation (GO:0046643)7.32132766
11regulation of necroptotic process (GO:0060544)6.97662389
12interferon-gamma production (GO:0032609)6.95853124
13necroptotic process (GO:0070266)6.76970833
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.76043743
15negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)6.43667374
16negative regulation of T-helper cell differentiation (GO:0045623)6.43667374
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.29260461
18alpha-beta T cell differentiation (GO:0046632)6.12299299
19T cell receptor signaling pathway (GO:0050852)6.11244828
20regulation of regulatory T cell differentiation (GO:0045589)6.10994747
21regulation of T-helper 1 cell differentiation (GO:0045625)6.01526071
22negative regulation of peptidyl-serine phosphorylation (GO:0033137)5.85444583
23regulation of RIG-I signaling pathway (GO:0039535)5.76352563
24alpha-beta T cell activation (GO:0046631)5.75697162
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.67940297
26negative thymic T cell selection (GO:0045060)5.67275345
27T cell differentiation (GO:0030217)5.59065301
28negative regulation of necroptotic process (GO:0060546)5.44624997
29regulation of thymocyte apoptotic process (GO:0070243)5.44088564
30programmed necrotic cell death (GO:0097300)5.37863830
31positive thymic T cell selection (GO:0045059)5.32691857
32regulation of female gonad development (GO:2000194)5.28274947
33negative regulation of cell killing (GO:0031342)5.22525536
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.22525536
35necrotic cell death (GO:0070265)5.22114641
36antigen receptor-mediated signaling pathway (GO:0050851)5.11745464
37somatic cell DNA recombination (GO:0016444)5.09193938
38somatic diversification of immune receptors via germline recombination within a single locus (GO:0005.09193938
39negative regulation of T cell apoptotic process (GO:0070233)4.97704302
40positive regulation of interleukin-2 production (GO:0032743)4.96090401
41lymphocyte costimulation (GO:0031294)4.91561551
42thymic T cell selection (GO:0045061)4.91453174
43T cell costimulation (GO:0031295)4.88593993
44regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.87259823
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.81570748
46regulation of interleukin-2 biosynthetic process (GO:0045076)4.78307513
47Peyers patch development (GO:0048541)4.78171886
48mucosal-associated lymphoid tissue development (GO:0048537)4.78171886
49mast cell activation (GO:0045576)4.73976943
50CD4-positive, alpha-beta T cell differentiation (GO:0043367)4.68155918
51mature B cell differentiation involved in immune response (GO:0002313)4.65669903
52somatic diversification of immune receptors (GO:0002200)4.64755544
53positive regulation of T cell cytokine production (GO:0002726)4.62594939
54fat-soluble vitamin biosynthetic process (GO:0042362)4.60812729
55modulation by virus of host process (GO:0019054)4.59086024
56regulation of T-helper 2 cell differentiation (GO:0045628)4.55062060
57regulation of T cell receptor signaling pathway (GO:0050856)4.53773445
58positive regulation of calcium-mediated signaling (GO:0050850)4.49537934
59regulation of necrotic cell death (GO:0010939)4.41414050
60T cell differentiation in thymus (GO:0033077)4.33848655
61negative regulation of alpha-beta T cell differentiation (GO:0046639)4.33751980
62negative regulation of necrotic cell death (GO:0060547)4.32053563
63protein localization to Golgi apparatus (GO:0034067)4.25954715
64CD4-positive, alpha-beta T cell activation (GO:0035710)4.24188876
65mature B cell differentiation (GO:0002335)4.13933131
66T-helper cell differentiation (GO:0042093)4.10252157
67CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.10252157
68response to interleukin-15 (GO:0070672)4.08602773
69T cell activation (GO:0042110)4.07878495
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.06767059
71T cell homeostasis (GO:0043029)4.04767195
72regulation of T cell tolerance induction (GO:0002664)4.02227645
73genitalia morphogenesis (GO:0035112)3.97601614
74leukocyte aggregation (GO:0070486)3.96124280
75negative regulation of alpha-beta T cell activation (GO:0046636)3.94553292
76lymphocyte differentiation (GO:0030098)3.91824190
77cellular response to interleukin-15 (GO:0071350)3.91161512
78regulation of memory T cell differentiation (GO:0043380)3.84452979
79regulation of interleukin-2 production (GO:0032663)3.81813024
80regulation of isotype switching to IgG isotypes (GO:0048302)3.80783349
81regulation of interleukin-13 production (GO:0032656)3.80463774
82modulation by symbiont of host cellular process (GO:0044068)3.77946193
83T cell lineage commitment (GO:0002360)3.76928168
84mast cell activation involved in immune response (GO:0002279)3.75606920
85mast cell degranulation (GO:0043303)3.75606920
86regulation of glycogen (starch) synthase activity (GO:2000465)3.72308199
87positive regulation of interleukin-4 production (GO:0032753)3.68527928
88alpha-beta T cell activation involved in immune response (GO:0002287)3.60513868
89T cell differentiation involved in immune response (GO:0002292)3.60513868
90alpha-beta T cell differentiation involved in immune response (GO:0002293)3.60513868
91B cell receptor signaling pathway (GO:0050853)3.60088413
92positive regulation of isotype switching (GO:0045830)3.59324321
93lymph node development (GO:0048535)3.58801095
94purine deoxyribonucleotide metabolic process (GO:0009151)3.56142351
95purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.53444846
96positive regulation of natural killer cell mediated immunity (GO:0002717)3.51411015
97positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.51411015
98negative regulation of type 2 immune response (GO:0002829)3.47391230
99T cell mediated immunity (GO:0002456)3.46480893
100regulation of dendritic cell antigen processing and presentation (GO:0002604)3.44641172
101immune response-activating cell surface receptor signaling pathway (GO:0002429)3.43910655
102generation of neurons (GO:0048699)3.43456243
103negative regulation of lymphocyte apoptotic process (GO:0070229)3.42181148
104regulation of defense response to virus by virus (GO:0050690)3.42158505
105positive regulation of alpha-beta T cell proliferation (GO:0046641)3.41524869
106lymphocyte homeostasis (GO:0002260)3.41352703
107B cell proliferation (GO:0042100)3.40462778
108positive regulation of granulocyte differentiation (GO:0030854)3.40441547
109protein targeting to peroxisome (GO:0006625)3.36815869
110establishment of protein localization to peroxisome (GO:0072663)3.36815869
111protein localization to peroxisome (GO:0072662)3.36815869
112regulation of B cell receptor signaling pathway (GO:0050855)3.35950155
113regulation of T cell cytokine production (GO:0002724)3.35693503
114regulation of natural killer cell mediated immunity (GO:0002715)3.35057701
115regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.35057701
116regulation of T-helper 1 type immune response (GO:0002825)3.34987204
117antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33979913
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33979913
119regulation of chronic inflammatory response (GO:0002676)3.33311826
120tolerance induction (GO:0002507)3.33046160
121negative regulation of T cell receptor signaling pathway (GO:0050860)3.30931480
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28148323
123mitochondrial fission (GO:0000266)3.27819558
124regulation of T cell differentiation (GO:0045580)3.27120999
125regulation of interleukin-4 production (GO:0032673)3.24319353
126negative regulation by host of viral transcription (GO:0043922)3.22542157
127regulation of T cell apoptotic process (GO:0070232)3.21431797
128purine deoxyribonucleotide catabolic process (GO:0009155)3.20364573
129T cell proliferation (GO:0042098)3.18734633
130positive regulation of T-helper cell differentiation (GO:0045624)3.17529909
131regulation of B cell differentiation (GO:0045577)3.17181404
132positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.15391206
133regulation of alpha-beta T cell proliferation (GO:0046640)3.14262660
134positive regulation of T cell differentiation (GO:0045582)3.12744270
135positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.12494932
136peroxisomal transport (GO:0043574)3.12407679
137negative regulation of interleukin-17 production (GO:0032700)3.12125847
138purine nucleotide salvage (GO:0032261)3.09544035
139negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.06590091
140lymphocyte activation (GO:0046649)3.06589351
141neutrophil activation involved in immune response (GO:0002283)3.05332212
142regulation of interleukin-17 production (GO:0032660)3.04760606
143negative regulation of neurotransmitter secretion (GO:0046929)3.04631676
144negative regulation of interleukin-10 production (GO:0032693)3.04459903
145positive regulation of T cell activation (GO:0050870)3.04372398
146regulation of calcium-mediated signaling (GO:0050848)3.02836112
147lymphocyte proliferation (GO:0046651)3.02689304
148sphingomyelin metabolic process (GO:0006684)3.00051737
149regulation of granulocyte differentiation (GO:0030852)2.99268046
150positive regulation of tolerance induction (GO:0002645)2.98998778
151regulation of T cell mediated cytotoxicity (GO:0001914)2.98821646
152positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.98258598
153regulation of isotype switching (GO:0045191)2.98171000
154T cell migration (GO:0072678)2.97684453
155positive regulation of cell killing (GO:0031343)2.96912549
156leukocyte homeostasis (GO:0001776)2.96804541
157regulation of cellular extravasation (GO:0002691)2.96010069
158peroxisome fission (GO:0016559)2.95855431
159positive regulation of DNA recombination (GO:0045911)2.95602166
160positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95233707
161regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.92652312
162regulation of T-helper cell differentiation (GO:0045622)2.90165724
163cellular response to prostaglandin stimulus (GO:0071379)2.89212349
164regulation of alpha-beta T cell activation (GO:0046634)2.89204313
165regulation of type 2 immune response (GO:0002828)2.88630206
166I-kappaB phosphorylation (GO:0007252)2.88140926
167regulation of interleukin-10 production (GO:0032653)2.87834687
168mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.87660503
169positive regulation of alpha-beta T cell differentiation (GO:0046638)2.87097317
170positive regulation of alpha-beta T cell activation (GO:0046635)2.86123462
171positive regulation of type 2 immune response (GO:0002830)2.83750051
172V(D)J recombination (GO:0033151)10.6037495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.71179786
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.22581954
3E2F7_22180533_ChIP-Seq_HELA_Human4.50365653
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.41279685
5* RUNX_20019798_ChIP-Seq_JUKART_Human4.10377338
6* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.85926862
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.76398733
8MYB_26560356_Chip-Seq_TH2_Human3.67682390
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.33548487
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20556228
11MYC_22102868_ChIP-Seq_BL_Human3.13977708
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.98883348
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88343288
14UTX_26944678_Chip-Seq_JUKART_Human2.70765251
15SCL_19346495_ChIP-Seq_HPC-7_Human2.66347602
16MAF_26560356_Chip-Seq_TH1_Human2.61436037
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61333527
18MYB_26560356_Chip-Seq_TH1_Human2.53988776
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53776513
20* GATA3_27048872_Chip-Seq_THYMUS_Human2.53622591
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49893084
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29154705
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21302455
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12104004
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.06576322
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.05712936
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01117701
28RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.95106883
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88600685
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84025978
31* TCF7_22412390_ChIP-Seq_EML_Mouse1.81223028
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79868865
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.79271863
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.75505473
35VDR_21846776_ChIP-Seq_THP-1_Human1.72064868
36* IRF8_27001747_Chip-Seq_BMDM_Mouse1.71102328
37* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66789540
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66565362
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66132610
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64182460
41VDR_24763502_ChIP-Seq_THP-1_Human1.62529426
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60659741
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60473180
44SPI1_23547873_ChIP-Seq_NB4_Human1.55241607
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.53040786
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49893912
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47435906
48CIITA_25753668_ChIP-Seq_RAJI_Human1.46832640
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46093211
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43509206
51MAF_26560356_Chip-Seq_TH2_Human1.40458337
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35922880
53GATA3_26560356_Chip-Seq_TH2_Human1.35742942
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29957272
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29685298
56PU_27001747_Chip-Seq_BMDM_Mouse1.25928979
57KDM2B_26808549_Chip-Seq_DND41_Human1.25385205
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21371309
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21169060
60SPI1_23127762_ChIP-Seq_K562_Human1.19759259
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18023595
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16415205
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14275836
64* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12163248
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.11573280
66GATA1_19941826_ChIP-Seq_K562_Human1.09019226
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06379961
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04419155
69VDR_24787735_ChIP-Seq_THP-1_Human1.03318027
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02863786
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02036575
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01328678
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00381863
74* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00169996
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97972852
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.97782129
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96662327
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96126278
79ELK1_19687146_ChIP-ChIP_HELA_Human0.93205385
80BP1_19119308_ChIP-ChIP_Hs578T_Human0.93083915
81HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91885503
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90862627
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90579865
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90259478
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89765965
86GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88415334
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88158391
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87832063
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87175692
90IGF1R_20145208_ChIP-Seq_DFB_Human0.86986029
91ESR1_20079471_ChIP-ChIP_T-47D_Human0.86555020
92PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85817611
93* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84623875
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84218323
95FOXP3_21729870_ChIP-Seq_TREG_Human0.84129081
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84065288
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83732080
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.83293441
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81893512
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79360504
101VDR_23849224_ChIP-Seq_CD4+_Human0.78988829
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78708849
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77828657
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.77585974
105SALL4_22934838_ChIP-ChIP_CD34+_Human0.75877525
106ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75598137
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74913905
108PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74795022
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.74461237
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73860967
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72865193
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.70567869
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68039487
114AR_21572438_ChIP-Seq_LNCaP_Human0.67916035
115* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.66202959
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64057983
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.63991546
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.63819856
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.63095114
120* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63025208
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62100349
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.61983276
123* GATA2_19941826_ChIP-Seq_K562_Human0.61830626
124SMRT_27268052_Chip-Seq_Bcells_Human0.59048570
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.58167497
126GATA3_26560356_Chip-Seq_TH1_Human0.56921117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.46553687
2MP0005671_abnormal_response_to4.62747033
3MP0002166_altered_tumor_susceptibility4.04380092
4MP0005409_darkened_coat_color3.98095344
5* MP0000703_abnormal_thymus_morphology3.45897386
6MP0002132_abnormal_respiratory_system3.39908235
7MP0002006_tumorigenesis3.27556437
8MP0003806_abnormal_nucleotide_metabolis3.22347686
9MP0001835_abnormal_antigen_presentation3.15882335
10MP0009785_altered_susceptibility_to2.84180474
11MP0000685_abnormal_immune_system2.82497771
12MP0005387_immune_system_phenotype2.65730315
13MP0001790_abnormal_immune_system2.65730315
14MP0004947_skin_inflammation2.63728920
15* MP0002398_abnormal_bone_marrow2.59899675
16MP0001800_abnormal_humoral_immune2.56203192
17MP0002933_joint_inflammation2.32694961
18MP0002420_abnormal_adaptive_immunity2.30261549
19MP0006082_CNS_inflammation2.29844657
20MP0001819_abnormal_immune_cell2.28528275
21MP0005000_abnormal_immune_tolerance2.27246878
22MP0000015_abnormal_ear_pigmentation2.26797594
23MP0002723_abnormal_immune_serum2.23353276
24MP0003300_gastrointestinal_ulcer2.21703823
25* MP0000716_abnormal_immune_system2.19855822
26* MP0002722_abnormal_immune_system2.18764996
27MP0001873_stomach_inflammation2.18700650
28MP0005174_abnormal_tail_pigmentation2.15328498
29MP0002405_respiratory_system_inflammati2.14660090
30* MP0010155_abnormal_intestine_physiology2.13345421
31MP0009333_abnormal_splenocyte_physiolog2.05871162
32MP0000689_abnormal_spleen_morphology1.98040582
33MP0002452_abnormal_antigen_presenting1.97492564
34MP0008877_abnormal_DNA_methylation1.97056311
35MP0005025_abnormal_response_to1.95816079
36MP0009278_abnormal_bone_marrow1.93074602
37MP0010094_abnormal_chromosome_stability1.92716518
38MP0002095_abnormal_skin_pigmentation1.91223479
39MP0004808_abnormal_hematopoietic_stem1.88769794
40MP0001853_heart_inflammation1.88594385
41MP0002148_abnormal_hypersensitivity_rea1.87040239
42MP0003303_peritoneal_inflammation1.75756711
43* MP0002429_abnormal_blood_cell1.70937744
44MP0005310_abnormal_salivary_gland1.68490349
45MP0003724_increased_susceptibility_to1.67924043
46MP0001188_hyperpigmentation1.59311582
47MP0005397_hematopoietic_system_phenotyp1.57146975
48MP0001545_abnormal_hematopoietic_system1.57146975
49MP0002009_preneoplasia1.57020191
50MP0001849_ear_inflammation1.55227018
51MP0002127_abnormal_cardiovascular_syste1.50772388
52MP0001764_abnormal_homeostasis1.44607281
53MP0002138_abnormal_hepatobiliary_system1.43562920
54MP0003453_abnormal_keratinocyte_physiol1.42896729
55MP0001177_atelectasis1.42850803
56MP0002396_abnormal_hematopoietic_system1.42215391
57MP0002419_abnormal_innate_immunity1.36994144
58MP0000490_abnormal_crypts_of1.36582294
59MP0003183_abnormal_peptide_metabolism1.34872284
60* MP0001845_abnormal_inflammatory_respons1.32080292
61MP0002876_abnormal_thyroid_physiology1.29129674
62MP0000681_abnormal_thyroid_gland1.26712663
63MP0004381_abnormal_hair_follicle1.23028029
64MP0003866_abnormal_defecation1.21903296
65MP0000678_abnormal_parathyroid_gland1.21690797
66MP0001879_abnormal_lymphatic_vessel1.18735892
67MP0009697_abnormal_copulation1.15093489
68MP0003787_abnormal_imprinting1.13958843
69MP0003868_abnormal_feces_composition1.10179172
70MP0005464_abnormal_platelet_physiology1.09076865
71MP0003436_decreased_susceptibility_to1.05578116
72MP0002998_abnormal_bone_remodeling1.01223037
73MP0004510_myositis1.00199118
74MP0002075_abnormal_coat/hair_pigmentati0.99700607
75MP0008007_abnormal_cellular_replicative0.99131860
76MP0005266_abnormal_metabolism0.98739180
77MP0002089_abnormal_postnatal_growth/wei0.98370531
78MP0000858_altered_metastatic_potential0.92703210
79MP0008057_abnormal_DNA_replication0.92672566
80MP0004883_abnormal_blood_vessel0.92358341
81MP0003252_abnormal_bile_duct0.90012638
82MP0000383_abnormal_hair_follicle0.89205812
83MP0005376_homeostasis/metabolism_phenot0.88978828
84MP0002019_abnormal_tumor_incidence0.85942865
85MP0001348_abnormal_lacrimal_gland0.83429571
86MP0003123_paternal_imprinting0.82191275
87MP0001243_abnormal_dermal_layer0.80441991
88MP0001663_abnormal_digestive_system0.79999853
89MP0005535_abnormal_body_temperature0.77950738
90MP0002837_dystrophic_cardiac_calcinosis0.77412480
91MP0001186_pigmentation_phenotype0.76747883
92MP0003646_muscle_fatigue0.76370530
93MP0001666_abnormal_nutrient_absorption0.74924738
94MP0000372_irregular_coat_pigmentation0.74168608
95MP0009115_abnormal_fat_cell0.73890111
96MP0005075_abnormal_melanosome_morpholog0.73773632
97MP0001919_abnormal_reproductive_system0.73298783
98MP0000465_gastrointestinal_hemorrhage0.72437452
99MP0003045_fibrosis0.72167843
100MP0008058_abnormal_DNA_repair0.68705293
101MP0005076_abnormal_cell_differentiation0.68670803
102MP0008569_lethality_at_weaning0.68039898
103MP0001216_abnormal_epidermal_layer0.67479226
104MP0005410_abnormal_fertilization0.67188865
105MP0008961_abnormal_basal_metabolism0.67079390
106MP0001851_eye_inflammation0.65816556
107MP0005388_respiratory_system_phenotype0.65340271
108MP0002133_abnormal_respiratory_system0.65340271
109MP0001191_abnormal_skin_condition0.65330253
110MP0005451_abnormal_body_composition0.64828934
111MP0003448_altered_tumor_morphology0.64814047
112MP0008469_abnormal_protein_level0.63916985
113MP0000920_abnormal_myelination0.62642271
114MP0009672_abnormal_birth_weight0.62493608
115MP0004036_abnormal_muscle_relaxation0.61096714
116MP0002971_abnormal_brown_adipose0.59982597
117MP0008873_increased_physiological_sensi0.59366216
118MP0000313_abnormal_cell_death0.58909044
119MP0003959_abnormal_lean_body0.57334736
120MP0002163_abnormal_gland_morphology0.57111424
121MP0001664_abnormal_digestion0.56982530
122MP0003795_abnormal_bone_structure0.56763475
123MP0000750_abnormal_muscle_regeneration0.53570540
124MP0000249_abnormal_blood_vessel0.51701030
125MP0001533_abnormal_skeleton_physiology0.51469129
126MP0000477_abnormal_intestine_morphology0.50993045
127MP0003693_abnormal_embryo_hatching0.50872465
128MP0003077_abnormal_cell_cycle0.49500638
129MP0003943_abnormal_hepatobiliary_system0.48521460
130MP0000367_abnormal_coat/_hair0.48156537
131MP0009765_abnormal_xenobiotic_induced0.46925319
132MP0010352_gastrointestinal_tract_polyps0.46237758
133MP0002083_premature_death0.46006944
134MP0000627_abnormal_mammary_gland0.45720915
135MP0006035_abnormal_mitochondrial_morpho0.43467063
136MP0004130_abnormal_muscle_cell0.43375287
137MP0003828_pulmonary_edema0.42917019
138MP0005389_reproductive_system_phenotype0.41234634
139MP0008770_decreased_survivor_rate0.40547473
140MP0005381_digestive/alimentary_phenotyp0.39665974

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)9.84928002
2Abnormality of B cell number (HP:0010975)9.84928002
3Abnormality of T cell number (HP:0011839)9.77209474
4Severe combined immunodeficiency (HP:0004430)8.99794815
5Hypoplasia of the thymus (HP:0000778)8.51801417
6Thyroiditis (HP:0100646)8.47054028
7Panhypogammaglobulinemia (HP:0003139)8.12685988
8Combined immunodeficiency (HP:0005387)7.78630595
9Eosinophilia (HP:0001880)7.19591397
10Recurrent viral infections (HP:0004429)6.24030569
11Hypoproteinemia (HP:0003075)6.17003687
12Granulocytopenia (HP:0001913)5.87260457
13Abnormality of eosinophils (HP:0001879)5.78041801
14Abnormality of T cells (HP:0002843)5.30051316
15Thin bony cortex (HP:0002753)5.12868339
16Abnormality of the costochondral junction (HP:0000919)4.96191000
17Enlarged epiphyses (HP:0010580)4.76760468
18Neonatal respiratory distress (HP:0002643)4.70344072
19IgG deficiency (HP:0004315)4.69819231
20Recurrent fungal infections (HP:0002841)4.68690586
21Metaphyseal dysplasia (HP:0100255)4.64127311
22Ankyloglossia (HP:0010296)4.40035895
23Leukocytosis (HP:0001974)4.30691451
24Erythroderma (HP:0001019)3.99572739
25Retrobulbar optic neuritis (HP:0100654)3.98931463
26Optic neuritis (HP:0100653)3.98931463
27Brushfield spots (HP:0001088)3.97171615
28Myositis (HP:0100614)3.85702194
29Delayed epiphyseal ossification (HP:0002663)3.74235875
30Limb hypertonia (HP:0002509)3.72408819
31Submucous cleft hard palate (HP:0000176)3.61038988
32Meningitis (HP:0001287)3.58265146
33Orchitis (HP:0100796)3.42874053
34Abnormality of the phalanges of the 2nd finger (HP:0009541)3.41259705
35Papilledema (HP:0001085)3.39164569
36Thickened helices (HP:0000391)3.26775556
37Widely patent fontanelles and sutures (HP:0004492)3.22391595
38Abnormality of oral frenula (HP:0000190)3.21517832
39Elevated erythrocyte sedimentation rate (HP:0003565)3.09386009
40Abnormality of the fingertips (HP:0001211)3.08516206
41Colitis (HP:0002583)3.07437884
42Acute hepatic failure (HP:0006554)2.99004770
43Aplasia/Hypoplasia of the thymus (HP:0010515)2.91360646
44Increased IgE level (HP:0003212)2.90704997
45Abnormal epiphyseal ossification (HP:0010656)2.90345772
46Gastrointestinal inflammation (HP:0004386)2.88802380
47Keratoconjunctivitis sicca (HP:0001097)2.82538111
48Alveolar cell carcinoma (HP:0006519)2.69363679
49Encephalitis (HP:0002383)2.66561600
50Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.65588006
51Metaphyseal irregularity (HP:0003025)2.62923714
52Abnormality of the prostate (HP:0008775)2.62107087
53Neoplasm of the tracheobronchial system (HP:0100552)2.60299585
54Keratoconjunctivitis (HP:0001096)2.58570781
55IgA deficiency (HP:0002720)2.58551717
56Hemoptysis (HP:0002105)2.57476789
57Spinal cord lesions (HP:0100561)2.47706091
58Syringomyelia (HP:0003396)2.47706091
59Progressive microcephaly (HP:0000253)2.44278247
60Cavernous hemangioma (HP:0001048)2.44220412
61Chronic mucocutaneous candidiasis (HP:0002728)2.42039128
62Recurrent cutaneous fungal infections (HP:0011370)2.42039128
63Flat occiput (HP:0005469)2.41244254
64Thoracic kyphosis (HP:0002942)2.40601037
65Beaking of vertebral bodies (HP:0004568)2.38874733
66Lymphoma (HP:0002665)2.38617256
67Abnormality of the thymus (HP:0000777)2.35990219
68Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.35782109
69Abnormality of the periventricular white matter (HP:0002518)2.35130330
70Pulmonary infiltrates (HP:0002113)2.34468950
71Hypophosphatemia (HP:0002148)2.31419408
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.31357156
73Short middle phalanx of the 5th finger (HP:0004220)2.28434378
74IgM deficiency (HP:0002850)2.28162938
75Volvulus (HP:0002580)2.27449244
76Gangrene (HP:0100758)2.27113425
77Autoimmune thrombocytopenia (HP:0001973)2.26098420
78Thickened calvaria (HP:0002684)2.25587352
79Thickened nuchal skin fold (HP:0000474)2.23712705
80Vasculitis (HP:0002633)2.21181223
81Spondylolisthesis (HP:0003302)2.19788576
82Short foot (HP:0001773)2.19664618
83Chronic obstructive pulmonary disease (HP:0006510)2.14000787
84Obstructive lung disease (HP:0006536)2.14000787
85Menstrual irregularities (HP:0000858)2.13788449
86Hypoglycemic seizures (HP:0002173)2.12314802
87Abnormality of the pubic bones (HP:0003172)2.12303654
88Pulmonary embolism (HP:0002204)2.11793758
89Stomatitis (HP:0010280)2.11267266
90Epiphyseal stippling (HP:0010655)2.10427818
91Thoracolumbar scoliosis (HP:0002944)2.06891353
92Abnormality of DNA repair (HP:0003254)2.06369947
93Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.05160451
94Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.04771896
95Cellular immunodeficiency (HP:0005374)2.03725510
96Mask-like facies (HP:0000298)2.02285844
97T lymphocytopenia (HP:0005403)10.2252823
98Autoimmune hemolytic anemia (HP:0001890)1.99950093
99Abnormality of the 2nd finger (HP:0004100)1.99674972
100Severe global developmental delay (HP:0011344)1.98767309
101Bilateral sensorineural hearing impairment (HP:0008619)1.98015287
102Barrel-shaped chest (HP:0001552)1.97819781
103Deep palmar crease (HP:0006191)1.96622709
104Ureteral stenosis (HP:0000071)1.95566750
105Sepsis (HP:0100806)1.94802982
106Chromsome breakage (HP:0040012)1.94800135
107Eczematoid dermatitis (HP:0000976)1.94075778
108Arterial thrombosis (HP:0004420)1.94032593
109Ureteral obstruction (HP:0006000)1.88363768
110Thrombocytosis (HP:0001894)1.88021991
111Partial agenesis of the corpus callosum (HP:0001338)1.88017272
112Deep philtrum (HP:0002002)1.87922496
113Increased IgM level (HP:0003496)1.87789275
114Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.87110291
115Difficulty walking (HP:0002355)1.84820894
116Acute lymphatic leukemia (HP:0006721)1.84201377
117Congenital primary aphakia (HP:0007707)1.83970748
118Nephrogenic diabetes insipidus (HP:0009806)1.83647197
119Rickets (HP:0002748)1.82436564
120Pustule (HP:0200039)1.80940465
121Joint swelling (HP:0001386)1.80366206
122Lymphopenia (HP:0001888)1.78698274
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.75442047
124Glomerulopathy (HP:0100820)1.72717462
125Recurrent bronchitis (HP:0002837)1.69580091
126Chronic diarrhea (HP:0002028)1.65921619
127Spontaneous hematomas (HP:0007420)1.63681020
128Bicuspid aortic valve (HP:0001647)1.62639091
129Chest pain (HP:0100749)1.62310853
130Abnormality of the pleura (HP:0002103)1.62300548
131Chronic otitis media (HP:0000389)1.60435413
132Type 2 muscle fiber atrophy (HP:0003554)1.59243336
133Abnormal hair whorl (HP:0010721)1.58636997
134Gastrointestinal infarctions (HP:0005244)1.55722760
135Verrucae (HP:0200043)1.53150047
136Papilloma (HP:0012740)1.53150047
137Muscle fiber atrophy (HP:0100295)1.51523313
138Keratitis (HP:0000491)1.49851871
139Recurrent skin infections (HP:0001581)1.48169131
140Abnormality of T cell physiology (HP:0011840)1.46731044
141Abnormality of male internal genitalia (HP:0000022)1.46525343
142Bronchiectasis (HP:0002110)1.45101371
143Epistaxis (HP:0000421)1.42763136
144Abnormality of the pericardium (HP:0001697)1.41641359
145Acute myeloid leukemia (HP:0004808)1.41596303
146Pruritus (HP:0000989)1.41019819
147Mediastinal lymphadenopathy (HP:0100721)1.40453440
148Recurrent abscess formation (HP:0002722)1.38609124
149Agammaglobulinemia (HP:0004432)1.30028992
150Polyneuropathy (HP:0001271)1.29262019
151Aortic valve stenosis (HP:0001650)1.28422409
152Cutis marmorata (HP:0000965)1.26920020
153Thrombophlebitis (HP:0004418)1.26861258
154Recurrent bacterial skin infections (HP:0005406)1.24753143
155Recurrent sinusitis (HP:0011108)1.23838871
156Weak cry (HP:0001612)1.23212597
157Long eyelashes (HP:0000527)1.23049104
158Inflammation of the large intestine (HP:0002037)1.21395709
159Abnormality of the endocardium (HP:0004306)1.20889507
160Prostate neoplasm (HP:0100787)1.20245324
161Prolonged bleeding time (HP:0003010)1.17745824
162Anorexia (HP:0002039)1.16885293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.37110734
2MAP4K13.88805304
3YES12.91032325
4ZAP702.75035669
5ICK2.58101799
6ITK2.34136952
7PRKD32.33640786
8MST42.31907039
9BRAF2.28539014
10ERN12.24916479
11SYK2.01487162
12TXK10.9608837
13GRK61.94054261
14NLK1.92010922
15MAPK71.80172610
16PDGFRB1.62219499
17TNIK1.62206091
18LCK1.60365827
19JAK31.59891983
20STK101.59730998
21TEC1.53708887
22FGFR31.42593270
23CSK1.41062397
24TYK21.40769136
25HCK1.39368683
26MAP3K21.37335802
27FGFR41.33307412
28IKBKE1.32558689
29MAP3K141.29093640
30CLK11.25650969
31PASK1.19724335
32PRKCQ1.18111008
33CDK121.16004884
34CAMKK21.15906974
35IRAK41.15559539
36PDK21.15305599
37CDK31.11967616
38BTK1.11239547
39SMG11.10299916
40SGK4941.07720731
41SGK2231.07720731
42MAP3K71.03819066
43JAK10.93066097
44PRKD20.90765199
45ADRBK20.89787946
46SIK30.89310590
47FRK0.88640490
48MAPK120.88442969
49BRD40.87185452
50CSNK1A1L0.86082398
51HIPK20.85196259
52FLT30.84298039
53CDK70.80553958
54PIK3CG0.78447935
55PRPF4B0.76719878
56CDK60.75607686
57JAK20.74416183
58STK40.73425575
59MAPK40.72296637
60TAOK30.71189486
61PRKCH0.70287407
62NME20.70146592
63TBK10.66134533
64PIM10.65814006
65FGFR20.65602531
66MARK20.63994636
67CSNK1G30.62784040
68SIK20.61313455
69EPHA30.60631687
70MAP3K100.60162534
71LYN0.59404408
72RIPK40.57820042
73PDK10.57200535
74NUAK10.56174218
75KIT0.55978444
76MAP2K30.55897311
77CHEK10.55350736
78MAP3K130.54091584
79IKBKB0.52748332
80MAPK100.52684583
81MKNK20.52595102
82EPHB10.52576389
83FYN0.51698010
84MAPK130.50693725
85CSNK1G10.49660873
86MAPK110.49096885
87CHUK0.48946415
88EIF2AK30.48524058
89CDK90.48230987
90INSR0.48197635
91BMPR20.47367778
92SGK10.47242652
93FES0.46625682
94MAP2K20.46534652
95TNK20.46239920
96SGK30.46184001
97STK240.44390929
98TSSK60.44367666
99TAOK10.43826903
100CAMK10.42828131
101RPS6KA40.42752142
102CSNK1G20.42485791
103RPS6KB20.41956263
104TRIB30.40945697
105NEK20.39494583
106CSF1R0.38877290
107CDC42BPA0.38349869
108CAMK40.38096820
109CDK40.37126021
110MAPK30.35974173
111CDC70.35237745
112RPS6KA50.35117963
113PTK60.33871863
114PKN20.32875289
115MARK30.32044358
116LRRK20.31826537
117MELK0.30943383
118OBSCN0.30679023
119PRKD10.30275891
120CAMKK10.28439679
121PRKG20.27016239
122SGK20.26379742
123ATR0.26242560
124EEF2K0.26144095
125IRAK10.24979816
126SRPK10.24929892
127EIF2AK20.24744089
128AKT20.24575673
129BLK0.24340716
130ABL10.22876238
131ATM0.20621624
132MAPKAPK20.20443178

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.78790714
2T cell receptor signaling pathway_Homo sapiens_hsa046604.40221936
3Sulfur metabolism_Homo sapiens_hsa009204.01833764
4Non-homologous end-joining_Homo sapiens_hsa034503.52103370
5Allograft rejection_Homo sapiens_hsa053302.87159748
6Autoimmune thyroid disease_Homo sapiens_hsa053202.85427393
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.81035819
8Hematopoietic cell lineage_Homo sapiens_hsa046402.68590799
9Antigen processing and presentation_Homo sapiens_hsa046122.63339156
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.36609251
11* Intestinal immune network for IgA production_Homo sapiens_hsa046722.36262268
12Measles_Homo sapiens_hsa051622.19774400
13Sphingolipid metabolism_Homo sapiens_hsa006002.08359600
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.95549441
15Systemic lupus erythematosus_Homo sapiens_hsa053221.80859889
16Selenocompound metabolism_Homo sapiens_hsa004501.65743501
17Leishmaniasis_Homo sapiens_hsa051401.62616141
18Asthma_Homo sapiens_hsa053101.62117584
19Sphingolipid signaling pathway_Homo sapiens_hsa040711.61250344
20Acute myeloid leukemia_Homo sapiens_hsa052211.58445269
21Alcoholism_Homo sapiens_hsa050341.51909800
22Thyroid cancer_Homo sapiens_hsa052161.48145108
23Graft-versus-host disease_Homo sapiens_hsa053321.42881047
24Osteoclast differentiation_Homo sapiens_hsa043801.41620047
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24548394
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.22802481
27Colorectal cancer_Homo sapiens_hsa052101.22794332
28Herpes simplex infection_Homo sapiens_hsa051681.20110457
29B cell receptor signaling pathway_Homo sapiens_hsa046621.19611152
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.14099537
31FoxO signaling pathway_Homo sapiens_hsa040681.12943617
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12365698
33Homologous recombination_Homo sapiens_hsa034401.12144397
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11889544
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11104690
36Chronic myeloid leukemia_Homo sapiens_hsa052201.10234586
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07141466
38Hepatitis B_Homo sapiens_hsa051611.02979708
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02838612
40Endometrial cancer_Homo sapiens_hsa052131.00268008
41HTLV-I infection_Homo sapiens_hsa051660.96491079
42Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95539881
43* Chemokine signaling pathway_Homo sapiens_hsa040620.94916333
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93185397
45Toxoplasmosis_Homo sapiens_hsa051450.92994355
46Influenza A_Homo sapiens_hsa051640.86417695
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85995227
48Prostate cancer_Homo sapiens_hsa052150.84389206
49Glycerolipid metabolism_Homo sapiens_hsa005610.80455244
50Viral myocarditis_Homo sapiens_hsa054160.80421901
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77572106
52Circadian rhythm_Homo sapiens_hsa047100.77550897
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76562636
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74679985
55* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74351627
56Spliceosome_Homo sapiens_hsa030400.74215735
57Staphylococcus aureus infection_Homo sapiens_hsa051500.73561899
58African trypanosomiasis_Homo sapiens_hsa051430.73322676
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71266210
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66910178
61Dorso-ventral axis formation_Homo sapiens_hsa043200.66618207
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65836136
63Steroid biosynthesis_Homo sapiens_hsa001000.65788103
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65585546
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64837148
66Pancreatic cancer_Homo sapiens_hsa052120.64532365
67Platelet activation_Homo sapiens_hsa046110.64390912
68Cholinergic synapse_Homo sapiens_hsa047250.62209793
69Adherens junction_Homo sapiens_hsa045200.59883246
70ErbB signaling pathway_Homo sapiens_hsa040120.59419455
71Malaria_Homo sapiens_hsa051440.59279468
72Type I diabetes mellitus_Homo sapiens_hsa049400.57603902
73Viral carcinogenesis_Homo sapiens_hsa052030.56334415
74Apoptosis_Homo sapiens_hsa042100.56244521
75Epstein-Barr virus infection_Homo sapiens_hsa051690.56218990
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56144636
77Shigellosis_Homo sapiens_hsa051310.55966567
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.55726105
79Cell cycle_Homo sapiens_hsa041100.55198019
80Pertussis_Homo sapiens_hsa051330.55131615
81Long-term depression_Homo sapiens_hsa047300.54611529
82Rheumatoid arthritis_Homo sapiens_hsa053230.54102803
83Non-small cell lung cancer_Homo sapiens_hsa052230.53261110
84RNA degradation_Homo sapiens_hsa030180.52392601
85mRNA surveillance pathway_Homo sapiens_hsa030150.51067239
86Tuberculosis_Homo sapiens_hsa051520.50591678
87TNF signaling pathway_Homo sapiens_hsa046680.48609515
88MicroRNAs in cancer_Homo sapiens_hsa052060.48025862
89Morphine addiction_Homo sapiens_hsa050320.47336401
90Insulin resistance_Homo sapiens_hsa049310.46142593
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44764791
92Calcium signaling pathway_Homo sapiens_hsa040200.44525549
93DNA replication_Homo sapiens_hsa030300.44256425
94Wnt signaling pathway_Homo sapiens_hsa043100.44017688
95Prolactin signaling pathway_Homo sapiens_hsa049170.42890519
96Glioma_Homo sapiens_hsa052140.42878148
97Legionellosis_Homo sapiens_hsa051340.41511978
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41213880
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40549685
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40466267
101Lysine degradation_Homo sapiens_hsa003100.40046769
102Base excision repair_Homo sapiens_hsa034100.39804323
103p53 signaling pathway_Homo sapiens_hsa041150.39177464
104Hepatitis C_Homo sapiens_hsa051600.38922974
105Fanconi anemia pathway_Homo sapiens_hsa034600.38724060
106Thyroid hormone synthesis_Homo sapiens_hsa049180.38537022
107mTOR signaling pathway_Homo sapiens_hsa041500.37955280
108GnRH signaling pathway_Homo sapiens_hsa049120.37351159
109Choline metabolism in cancer_Homo sapiens_hsa052310.37134426
110Pathways in cancer_Homo sapiens_hsa052000.36483751
111Serotonergic synapse_Homo sapiens_hsa047260.36238506
112Butanoate metabolism_Homo sapiens_hsa006500.35513803
113Mismatch repair_Homo sapiens_hsa034300.34251317
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.34217251
115Basal cell carcinoma_Homo sapiens_hsa052170.33033756
116Notch signaling pathway_Homo sapiens_hsa043300.32905764
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.31970727
118Inositol phosphate metabolism_Homo sapiens_hsa005620.31869486
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.31625025
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31522206
121MAPK signaling pathway_Homo sapiens_hsa040100.29973293
122Long-term potentiation_Homo sapiens_hsa047200.29750066
123Estrogen signaling pathway_Homo sapiens_hsa049150.27781986
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26583883
125Amphetamine addiction_Homo sapiens_hsa050310.26421442
126Small cell lung cancer_Homo sapiens_hsa052220.26234329
127Rap1 signaling pathway_Homo sapiens_hsa040150.24229234
128Salmonella infection_Homo sapiens_hsa051320.23777666
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22907288
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22837489
131Renal cell carcinoma_Homo sapiens_hsa052110.22723969
132Basal transcription factors_Homo sapiens_hsa030220.20348728
133Ras signaling pathway_Homo sapiens_hsa040140.19157356
134Melanogenesis_Homo sapiens_hsa049160.17012598

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