CCRL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.05346626
2positive regulation by symbiont of host defense response (GO:0052509)5.93969763
3modulation by symbiont of host defense response (GO:0052031)5.93969763
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.93969763
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.93969763
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.93969763
7modulation by symbiont of host immune response (GO:0052553)5.93969763
8neutrophil activation involved in immune response (GO:0002283)5.36778663
9positive regulation of chemokine biosynthetic process (GO:0045080)5.08501434
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03554391
11positive regulation of heat generation (GO:0031652)4.82365500
12lipopolysaccharide-mediated signaling pathway (GO:0031663)4.80681278
13regulation of fever generation (GO:0031620)4.73892219
14macrophage activation involved in immune response (GO:0002281)4.56805861
15positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.38490885
16regulation of vitamin metabolic process (GO:0030656)4.35637986
17regulation of chemokine biosynthetic process (GO:0045073)4.23801803
18positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.20725355
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.19815036
20positive regulation of interferon-alpha production (GO:0032727)4.18214657
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.12363043
22regulation of interferon-alpha production (GO:0032647)4.01826199
23hydrogen peroxide biosynthetic process (GO:0050665)4.00983319
24microglial cell activation (GO:0001774)4.00230190
25response to muramyl dipeptide (GO:0032495)3.99773717
26granulocyte activation (GO:0036230)3.95070762
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.94230070
28response to host immune response (GO:0052572)3.94230070
29respiratory burst (GO:0045730)3.90622098
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83600470
31regulation of cytokine secretion involved in immune response (GO:0002739)3.77912816
32superoxide anion generation (GO:0042554)3.77070712
33regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.74847411
34T-helper 1 type immune response (GO:0042088)3.69444650
35regulation of T-helper 1 cell differentiation (GO:0045625)3.69394988
36detection of molecule of bacterial origin (GO:0032490)3.68069681
37regulation of heat generation (GO:0031650)3.66402834
38glycosphingolipid catabolic process (GO:0046479)3.63869603
39leukocyte aggregation (GO:0070486)3.62842409
40negative regulation of interleukin-17 production (GO:0032700)3.62758992
41regulation of mononuclear cell migration (GO:0071675)3.62141894
42immunoglobulin mediated immune response (GO:0016064)3.57590083
43oligosaccharide catabolic process (GO:0009313)3.57522343
44positive regulation of NF-kappaB import into nucleus (GO:0042346)3.57304791
45neutrophil activation (GO:0042119)3.56232237
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.53918926
47response to host (GO:0075136)3.53918926
48response to host defenses (GO:0052200)3.53918926
49reactive oxygen species biosynthetic process (GO:1903409)3.52970988
50eosinophil chemotaxis (GO:0048245)3.52762875
51regulation of interferon-beta biosynthetic process (GO:0045357)3.51011545
52myeloid cell activation involved in immune response (GO:0002275)3.49215512
53germinal center formation (GO:0002467)3.48838528
54NIK/NF-kappaB signaling (GO:0038061)3.48329752
55cellular extravasation (GO:0045123)3.43130846
56regulation of activation of Janus kinase activity (GO:0010533)3.42669700
57positive regulation of type 2 immune response (GO:0002830)3.41716779
58positive regulation of mast cell degranulation (GO:0043306)3.40687264
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.40687264
60regulation of heterotypic cell-cell adhesion (GO:0034114)3.39708778
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.38442970
62negative regulation of interleukin-12 production (GO:0032695)3.37680492
63macrophage activation (GO:0042116)3.36925877
64cellular response to interferon-beta (GO:0035458)3.36291210
65positive regulation of interleukin-12 production (GO:0032735)3.35825965
66positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.35285861
67negative regulation of cytokine production involved in immune response (GO:0002719)3.33310358
68glycolipid catabolic process (GO:0019377)3.32793808
69interferon-gamma-mediated signaling pathway (GO:0060333)3.31562344
70positive regulation of cellular amide metabolic process (GO:0034250)3.30451395
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29640239
72positive regulation of interferon-beta production (GO:0032728)3.27610453
73regulation of interleukin-17 production (GO:0032660)3.26146352
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.25652063
75regulation of mast cell degranulation (GO:0043304)3.25245535
76regulation of vitamin D biosynthetic process (GO:0060556)3.24600085
77cellular response to exogenous dsRNA (GO:0071360)3.24439843
78negative regulation of nitric oxide biosynthetic process (GO:0045019)3.23452885
79production of molecular mediator involved in inflammatory response (GO:0002532)3.21945988
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.21604758
81response to protozoan (GO:0001562)3.21248388
82positive regulation of antigen processing and presentation (GO:0002579)3.21063921
83cellular response to lipopolysaccharide (GO:0071222)3.21024652
84regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.20784105
85positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.19537938
86regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.18965482
87regulation of chronic inflammatory response (GO:0002676)3.17187087
88regulation of lymphocyte chemotaxis (GO:1901623)3.16074158
89monocyte chemotaxis (GO:0002548)3.15125404
90eosinophil migration (GO:0072677)3.14650157
91cellular response to molecule of bacterial origin (GO:0071219)3.13653985
92cellular response to thyroid hormone stimulus (GO:0097067)3.11595260
93positive regulation of interleukin-10 production (GO:0032733)3.11380782
94regulation of membrane protein ectodomain proteolysis (GO:0051043)3.10909777
95negative regulation of lipid storage (GO:0010888)3.10543950
96positive regulation of chemokine production (GO:0032722)3.10356673
97negative regulation of viral genome replication (GO:0045071)3.09908444
98type I interferon signaling pathway (GO:0060337)3.09280933
99cellular response to type I interferon (GO:0071357)3.09280933
100regulation of podosome assembly (GO:0071801)3.08668182
101regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07578813
102positive regulation of lymphocyte migration (GO:2000403)3.07154908
103regulation of interleukin-12 production (GO:0032655)3.06646873
104detection of other organism (GO:0098543)3.06236738
105response to type I interferon (GO:0034340)3.06073928
106myeloid dendritic cell activation (GO:0001773)3.06015564
107positive regulation of mast cell activation (GO:0033005)3.03329788
108positive regulation of interleukin-6 production (GO:0032755)3.01979838
109regulation of mast cell activation involved in immune response (GO:0033006)3.00459037
110detection of external biotic stimulus (GO:0098581)2.99531932
111positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99238951
112regulation of nitric oxide biosynthetic process (GO:0045428)2.98462984
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.98034556
114cytokine secretion (GO:0050663)2.96618815
115positive regulation of humoral immune response (GO:0002922)2.95752239
116myeloid dendritic cell differentiation (GO:0043011)2.95675072
117neutrophil chemotaxis (GO:0030593)2.95341361
118positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.95019212
119defense response to protozoan (GO:0042832)2.94736178
120positive regulation of toll-like receptor signaling pathway (GO:0034123)2.94541265
121leukocyte mediated cytotoxicity (GO:0001909)2.93655513
122positive regulation of gamma-delta T cell activation (GO:0046645)2.93169881
123regulation of NF-kappaB import into nucleus (GO:0042345)2.92483223
124positive regulation of acute inflammatory response (GO:0002675)2.92178766
125regulation of interleukin-8 biosynthetic process (GO:0045414)2.92036422
126positive regulation of cytokine biosynthetic process (GO:0042108)2.91721564
127ceramide catabolic process (GO:0046514)2.91680140
128regulation of T-helper 2 cell differentiation (GO:0045628)2.91567531
129positive regulation of nitric oxide biosynthetic process (GO:0045429)2.91189686
130dendritic cell differentiation (GO:0097028)2.89876176
131amino sugar catabolic process (GO:0046348)2.85280220
132regulation of cholesterol storage (GO:0010885)2.84836152
133regulation of T cell tolerance induction (GO:0002664)2.83968744
134regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.82339648
135negative regulation of myeloid cell apoptotic process (GO:0033033)2.81596988
136positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80070945
137regulation of type 2 immune response (GO:0002828)2.79236786
138regulation of antigen processing and presentation (GO:0002577)2.79008394
139negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77389851
140negative regulation of cell killing (GO:0031342)2.77389851
141branching involved in labyrinthine layer morphogenesis (GO:0060670)2.74591411
142cellular response to biotic stimulus (GO:0071216)2.73017899
143B cell mediated immunity (GO:0019724)2.71290392
144positive regulation of T-helper cell differentiation (GO:0045624)2.70233500
145cellular response to interferon-gamma (GO:0071346)2.68708297
146regulation of growth of symbiont in host (GO:0044126)2.68258165
147negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.68258165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.85815249
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.87563613
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.40645547
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.29357283
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.20725155
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.78441714
7* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.72661315
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64193275
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63371576
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.53500733
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26545415
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17437090
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12672647
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.09465416
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96025474
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72201436
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48665937
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41446145
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12800661
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.06388833
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04412286
22PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.87476719
23VDR_24787735_ChIP-Seq_THP-1_Human1.84859137
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84847753
25* SPI1_23547873_ChIP-Seq_NB4_Human1.80171641
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79068485
27RUNX_20019798_ChIP-Seq_JUKART_Human1.78528318
28SCL_19346495_ChIP-Seq_HPC-7_Human1.77000834
29PU_27001747_Chip-Seq_BMDM_Mouse1.65671165
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65299142
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64659047
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61832939
33* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57939671
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.57799511
35VDR_24763502_ChIP-Seq_THP-1_Human1.57496213
36MYB_26560356_Chip-Seq_TH2_Human1.45463847
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42336687
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42184159
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40895751
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.39368170
41* SPI1_23127762_ChIP-Seq_K562_Human1.38876328
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37962393
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37868424
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33682593
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32274110
46CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31800778
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30560474
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.29360966
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27359746
50PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25890974
51* GATA2_21666600_ChIP-Seq_HMVEC_Human1.24714093
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20888356
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20207595
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20142130
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14771354
56MAF_26560356_Chip-Seq_TH1_Human1.14135977
57GATA3_26560356_Chip-Seq_TH2_Human1.13500093
58* TCF7_22412390_ChIP-Seq_EML_Mouse1.11781038
59TFEB_21752829_ChIP-Seq_HELA_Human1.09619469
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07818031
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.07212014
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07198645
63GATA3_27048872_Chip-Seq_THYMUS_Human1.06773839
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06610182
65MYB_26560356_Chip-Seq_TH1_Human1.05447557
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02184941
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02111116
68LXR_22292898_ChIP-Seq_THP-1_Human1.01840725
69KDM2B_26808549_Chip-Seq_DND41_Human1.00837104
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00754210
71* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99733743
72GATA1_22025678_ChIP-Seq_K562_Human0.98868311
73STAT1_20625510_ChIP-Seq_HELA_Human0.98023412
74EGR1_19032775_ChIP-ChIP_M12_Human0.97505080
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97183059
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97183059
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94555560
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93874061
79MAF_26560356_Chip-Seq_TH2_Human0.93390682
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93197140
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92813063
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92417215
83* SOX2_20726797_ChIP-Seq_SW620_Human0.91060902
84RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91021169
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90979461
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89167174
87* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89162521
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87360734
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87125463
90RXR_22158963_ChIP-Seq_LIVER_Mouse0.86679539
91TP63_17297297_ChIP-ChIP_HaCaT_Human0.84681770
92LXR_22158963_ChIP-Seq_LIVER_Mouse0.82410626
93CJUN_26792858_Chip-Seq_BT549_Human0.81842761
94MYC_22102868_ChIP-Seq_BL_Human0.81276936
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80723789
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80261367
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79869700
98* NCOR1_26117541_ChIP-Seq_K562_Human0.79701418
99UTX_26944678_Chip-Seq_JUKART_Human0.79131874
100PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78931351
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78904430
102TRIM28_21343339_ChIP-Seq_HEK293_Human0.78673090
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78537762
104* GATA2_19941826_ChIP-Seq_K562_Human0.78391368
105PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78004856
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.76869100
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75915249
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75143342
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75143342
110GATA1_19941826_ChIP-Seq_K562_Human0.72872268
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70647567
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68499036
113VDR_21846776_ChIP-Seq_THP-1_Human0.68441551
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67758046
115* GATA1_19941827_ChIP-Seq_MEL_Mouse0.66264590
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.65577542
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65328724
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.65112230
119EGR1_23403033_ChIP-Seq_LIVER_Mouse0.63247583
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.61177053
121SMRT_27268052_Chip-Seq_Bcells_Human0.59751475
122SPI1_20517297_ChIP-Seq_HL60_Human0.59064349
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56642142
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56399130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.44719425
2MP0003436_decreased_susceptibility_to4.10025513
3MP0001835_abnormal_antigen_presentation4.09635911
4MP0006082_CNS_inflammation3.94985238
5MP0003724_increased_susceptibility_to3.86716550
6* MP0002148_abnormal_hypersensitivity_rea3.64252548
7MP0005000_abnormal_immune_tolerance3.48898438
8MP0002419_abnormal_innate_immunity3.42812851
9MP0003303_peritoneal_inflammation3.34045190
10MP0005025_abnormal_response_to3.11481080
11MP0005058_abnormal_lysosome_morphology2.66367320
12* MP0002452_abnormal_antigen_presenting2.61791650
13MP0005671_abnormal_response_to2.58937472
14MP0001790_abnormal_immune_system2.55827982
15MP0005387_immune_system_phenotype2.55827982
16* MP0002723_abnormal_immune_serum2.53714343
17MP0004510_myositis2.52354727
18MP0001800_abnormal_humoral_immune2.44372919
19MP0009764_decreased_sensitivity_to2.37504706
20MP0002139_abnormal_hepatobiliary_system2.37277105
21MP0004947_skin_inflammation2.30126536
22MP0005464_abnormal_platelet_physiology2.26085607
23MP0001533_abnormal_skeleton_physiology2.25378903
24MP0000685_abnormal_immune_system2.19900600
25* MP0001819_abnormal_immune_cell2.18741396
26* MP0002420_abnormal_adaptive_immunity2.15637616
27MP0005451_abnormal_body_composition2.00603626
28MP0003075_altered_response_to1.98449134
29MP0001845_abnormal_inflammatory_respons1.97278927
30MP0003191_abnormal_cellular_cholesterol1.95864563
31MP0000343_altered_response_to1.94563996
32MP0002006_tumorigenesis1.92248972
33MP0003172_abnormal_lysosome_physiology1.91315963
34MP0001853_heart_inflammation1.88965626
35MP0002405_respiratory_system_inflammati1.88040759
36MP0005167_abnormal_blood-brain_barrier1.83992353
37MP0008469_abnormal_protein_level1.79228183
38MP0003448_altered_tumor_morphology1.77751886
39MP0009278_abnormal_bone_marrow1.74400265
40MP0010155_abnormal_intestine_physiology1.60898276
41MP0009333_abnormal_splenocyte_physiolog1.59155341
42MP0006054_spinal_hemorrhage1.58623023
43MP0003828_pulmonary_edema1.55942800
44MP0003806_abnormal_nucleotide_metabolis1.55436106
45MP0002998_abnormal_bone_remodeling1.54651586
46MP0005310_abnormal_salivary_gland1.49210864
47MP0000716_abnormal_immune_system1.47780542
48MP0005166_decreased_susceptibility_to1.45243979
49MP0000858_altered_metastatic_potential1.45223329
50MP0009840_abnormal_foam_cell1.41971297
51MP0003690_abnormal_glial_cell1.40838900
52MP0005164_abnormal_response_to1.35409821
53MP0002398_abnormal_bone_marrow1.32663264
54MP0002254_reproductive_system_inflammat1.20513772
55MP0000604_amyloidosis1.19712102
56MP0005397_hematopoietic_system_phenotyp1.19155279
57MP0001545_abnormal_hematopoietic_system1.19155279
58MP0002429_abnormal_blood_cell1.15845561
59MP0002933_joint_inflammation1.14212428
60MP0004782_abnormal_surfactant_physiolog1.13173303
61MP0003656_abnormal_erythrocyte_physiolo1.12078970
62MP0005390_skeleton_phenotype1.10804310
63MP0003453_abnormal_keratinocyte_physiol1.09785180
64MP0000689_abnormal_spleen_morphology1.09543826
65MP0001851_eye_inflammation1.06660184
66MP0009763_increased_sensitivity_to1.06542723
67MP0002277_abnormal_respiratory_mucosa1.05590221
68MP0003186_abnormal_redox_activity1.04536296
69MP0000569_abnormal_digit_pigmentation1.02569383
70MP0008260_abnormal_autophagy1.00453099
71MP0002877_abnormal_melanocyte_morpholog0.97706927
72* MP0002722_abnormal_immune_system0.97057819
73MP0008004_abnormal_stomach_pH0.96722904
74MP0004883_abnormal_blood_vessel0.96677826
75MP0003195_calcinosis0.94279025
76MP0005076_abnormal_cell_differentiation0.90961679
77MP0000249_abnormal_blood_vessel0.90900677
78MP0003300_gastrointestinal_ulcer0.88785636
79MP0003329_amyloid_beta_deposits0.87985637
80MP0001663_abnormal_digestive_system0.81011782
81MP0005174_abnormal_tail_pigmentation0.79646877
82MP0000465_gastrointestinal_hemorrhage0.78935624
83MP0002138_abnormal_hepatobiliary_system0.77739405
84MP0003183_abnormal_peptide_metabolism0.77699498
85MP0001542_abnormal_bone_strength0.75085659
86MP0002332_abnormal_exercise_endurance0.74172867
87MP0003646_muscle_fatigue0.74012952
88MP0002166_altered_tumor_susceptibility0.73628257
89MP0000920_abnormal_myelination0.73246240
90MP0005165_increased_susceptibility_to0.71272430
91MP0008874_decreased_physiological_sensi0.68965545
92MP0010352_gastrointestinal_tract_polyps0.68450840
93MP0005647_abnormal_sex_gland0.66303259
94MP0000371_diluted_coat_color0.66043295
95MP0004808_abnormal_hematopoietic_stem0.65714489
96MP0002136_abnormal_kidney_physiology0.65267330
97MP0003795_abnormal_bone_structure0.64907455
98MP0001501_abnormal_sleep_pattern0.60911047
99MP0000609_abnormal_liver_physiology0.60865150
100MP0003566_abnormal_cell_adhesion0.59609493
101MP0009765_abnormal_xenobiotic_induced0.59392770
102MP0008873_increased_physiological_sensi0.57884299
103MP0010307_abnormal_tumor_latency0.57037001
104MP0003763_abnormal_thymus_physiology0.56464821
105MP0003091_abnormal_cell_migration0.56276563
106MP0005535_abnormal_body_temperature0.54271951
107MP0002693_abnormal_pancreas_physiology0.52657831
108MP0005319_abnormal_enzyme/_coenzyme0.52495565
109MP0003221_abnormal_cardiomyocyte_apopto0.52121628
110MP0002295_abnormal_pulmonary_circulatio0.52068745
111MP0000767_abnormal_smooth_muscle0.51879987
112MP0001873_stomach_inflammation0.51489191
113MP0004858_abnormal_nervous_system0.51156706
114MP0000490_abnormal_crypts_of0.50664901
115MP0005023_abnormal_wound_healing0.47460188
116MP0005257_abnormal_intraocular_pressure0.47395899
117MP0002090_abnormal_vision0.46920458

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.12794529
2Eczematoid dermatitis (HP:0000976)7.29732547
3Recurrent bacterial skin infections (HP:0005406)7.19215721
4Recurrent gram-negative bacterial infections (HP:0005420)6.61789339
5Stomatitis (HP:0010280)5.77740878
6Abnormality of macrophages (HP:0004311)5.49614635
7Mediastinal lymphadenopathy (HP:0100721)5.42634089
8Retrobulbar optic neuritis (HP:0100654)5.17935705
9Optic neuritis (HP:0100653)5.17935705
10Orchitis (HP:0100796)5.08039380
11Elevated erythrocyte sedimentation rate (HP:0003565)4.78440478
12Myositis (HP:0100614)4.68421411
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.53213535
14Increased cerebral lipofuscin (HP:0011813)4.49730252
15Gingivitis (HP:0000230)4.41403064
16Systemic lupus erythematosus (HP:0002725)4.28563896
17Recurrent skin infections (HP:0001581)4.25019404
18Loss of speech (HP:0002371)4.22437142
19Vacuolated lymphocytes (HP:0001922)4.12685947
20Autoimmune thrombocytopenia (HP:0001973)3.90934935
21Obstructive lung disease (HP:0006536)3.88144390
22Chronic obstructive pulmonary disease (HP:0006510)3.88144390
23Interstitial pulmonary disease (HP:0006530)3.78926732
24Recurrent fungal infections (HP:0002841)3.65909862
25Axonal loss (HP:0003447)3.58192041
26Vasculitis (HP:0002633)3.55873366
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.40910067
28Basal ganglia calcification (HP:0002135)3.31284309
29Mutism (HP:0002300)3.27133347
30Pulmonary infiltrates (HP:0002113)3.25914588
31Neurofibrillary tangles (HP:0002185)3.18088023
32Periodontitis (HP:0000704)3.10156674
33Disinhibition (HP:0000734)3.09720023
34Thick nail (HP:0001805)3.08222031
35Pustule (HP:0200039)3.05698369
36Keratoconjunctivitis sicca (HP:0001097)3.03604725
37Cellulitis (HP:0100658)2.97726741
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.94757677
39Recurrent viral infections (HP:0004429)2.92248990
40Urticaria (HP:0001025)2.90448014
41Nuclear cataract (HP:0100018)2.89483174
42Nausea (HP:0002018)2.86969877
43Abnormality of glycolipid metabolism (HP:0010969)2.83867633
44Abnormality of liposaccharide metabolism (HP:0010968)2.83867633
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.83867633
46Prostate neoplasm (HP:0100787)2.78249086
47Glomerulonephritis (HP:0000099)2.77927166
48Increased serum ferritin (HP:0003281)2.76812439
49Keratoconjunctivitis (HP:0001096)2.75702364
50Apathy (HP:0000741)2.74778868
51Increased IgM level (HP:0003496)2.74286034
52Diminished motivation (HP:0000745)2.70826885
53Meningitis (HP:0001287)2.69313837
54Chronic mucocutaneous candidiasis (HP:0002728)2.66175242
55Recurrent cutaneous fungal infections (HP:0011370)2.66175242
56Arterial thrombosis (HP:0004420)2.65268088
57Agnosia (HP:0010524)2.63846380
58Dysostosis multiplex (HP:0000943)2.58804025
59Tetraparesis (HP:0002273)2.57186422
60Leukocytosis (HP:0001974)2.55419819
61Recurrent pneumonia (HP:0006532)2.53975467
62Osteomyelitis (HP:0002754)2.53185145
63Hemoptysis (HP:0002105)2.52894850
64Progressive neurologic deterioration (HP:0002344)2.51759280
65Petechiae (HP:0000967)2.41377400
66Hepatosplenomegaly (HP:0001433)2.40951773
67T lymphocytopenia (HP:0005403)2.38503716
68Myocardial infarction (HP:0001658)2.38468928
69Polyneuropathy (HP:0001271)2.38030988
70Hematochezia (HP:0002573)2.35965426
71Neuronal loss in central nervous system (HP:0002529)2.33606105
72Abnormality of the pericardium (HP:0001697)2.29920984
73Premature loss of primary teeth (HP:0006323)2.29492986
74Autoimmune hemolytic anemia (HP:0001890)2.27341660
75Purpura (HP:0000979)2.27277997
76Inappropriate behavior (HP:0000719)2.25769024
77Abnormality of iron homeostasis (HP:0011031)2.24820616
78Cerebral inclusion bodies (HP:0100314)2.23747424
79Bone pain (HP:0002653)2.22054239
80Encephalitis (HP:0002383)2.21574665
81Nephritis (HP:0000123)2.16547736
82Joint swelling (HP:0001386)2.15505496
83Episodic fever (HP:0001954)2.15079761
84Metaphyseal irregularity (HP:0003025)2.12922124
85Joint hemorrhage (HP:0005261)2.11202298
86Hypergammaglobulinemia (HP:0010702)2.10830288
87Recurrent lower respiratory tract infections (HP:0002783)2.10784446
88Amyloidosis (HP:0011034)2.10699011
89Gingival bleeding (HP:0000225)2.04542249
90Abnormality of the pleura (HP:0002103)2.04266371
91Vertigo (HP:0002321)2.03091487
92Urinary glycosaminoglycan excretion (HP:0003541)2.02942714
93Mucopolysacchariduria (HP:0008155)2.02942714
94Arthralgia (HP:0002829)2.02748855
95Anorexia (HP:0002039)2.02742536
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.01723580
97Osteolytic defects of the hand bones (HP:0009699)2.01723580
98Progressive visual loss (HP:0000529)2.01201308
99Parakeratosis (HP:0001036)2.00873804
100Poor head control (HP:0002421)2.00472018
101Chronic otitis media (HP:0000389)1.99951398
102Colitis (HP:0002583)1.99276997
103Personality changes (HP:0000751)1.95176974
104Pathologic fracture (HP:0002756)1.92350670
105Vertebral compression fractures (HP:0002953)1.92037489
106Upper motor neuron abnormality (HP:0002127)1.91960146
107Asymmetric septal hypertrophy (HP:0001670)1.91746415
108Porencephaly (HP:0002132)1.91581139
109Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91482057
110Gangrene (HP:0100758)1.91183488
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90348599
112Abnormality of polysaccharide metabolism (HP:0011012)1.90348599
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90348599
114Spontaneous hematomas (HP:0007420)1.90049978
115Peripheral demyelination (HP:0011096)1.88047257
116Memory impairment (HP:0002354)1.85636526
117Glomerulopathy (HP:0100820)1.85597934
118Pulmonary embolism (HP:0002204)1.85556368
119Prolonged neonatal jaundice (HP:0006579)1.85328795
120Abnormality of the periventricular white matter (HP:0002518)1.83296090
121Dementia (HP:0000726)1.82840549
122Increased IgE level (HP:0003212)1.81994130
123Gastrointestinal infarctions (HP:0005244)1.81849580
124Sepsis (HP:0100806)1.81111134
125Increased CSF protein (HP:0002922)1.80862243
126Segmental peripheral demyelination/remyelination (HP:0003481)1.80814377
127Eosinophilia (HP:0001880)1.79104240
128Abnormality of T cell number (HP:0011839)1.77246629
129Abnormality of the endocardium (HP:0004306)1.76898413
130Skin ulcer (HP:0200042)1.75594108
131Albinism (HP:0001022)1.74151824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.95366512
2IRAK34.42404684
3BLK4.39964778
4RIPK44.28928757
5TBK13.82143205
6IRAK43.19000933
7TXK3.18337492
8MAP4K13.01359075
9TAOK22.89740730
10IKBKE2.78842391
11IKBKB2.71235286
12TYK22.53272834
13PBK2.38205140
14DDR22.34225730
15JAK32.16331715
16PRPF4B2.11698114
17TAOK11.95740965
18KIT1.92047592
19JAK11.78172321
20CHUK1.75221388
21FGR1.71755123
22PIM21.70511655
23TGFBR21.63143994
24CSK1.53237488
25BMPR21.53172365
26MST41.46546750
27ERN11.46239558
28ZAP701.45440194
29BMX1.36707160
30SYK1.31533530
31ACVR1B1.29269771
32EPHB11.22346521
33CDC42BPA1.21070953
34LYN1.20639196
35MAP3K131.19394674
36HCK1.16705528
37CSF1R1.15171045
38TESK21.14662700
39PIM11.12609881
40EIF2AK21.12349016
41ABL21.11637399
42MATK1.04770874
43STK101.04621232
44MARK31.02804532
45GRK71.02431010
46JAK21.01208461
47LCK1.01132043
48NEK90.93042034
49RPS6KA40.92443906
50MST1R0.89104672
51BTK0.89007350
52MAP3K100.87564099
53PRKCD0.87099800
54IRAK10.85787883
55IRAK20.84006766
56TEC0.83856621
57FES0.78914484
58CLK10.78863534
59TAOK30.74551877
60MAP2K30.67283918
61ABL10.66096196
62EGFR0.66000587
63TRPM70.62754894
64YES10.62323675
65MAP3K50.61781053
66MAP3K120.61452880
67ITK0.59410354
68NME20.57004479
69BMPR1B0.56615166
70ERBB30.56482063
71TYRO30.55669311
72EPHA30.55661408
73DAPK20.55401563
74ERBB40.55064943
75ADRBK20.54635786
76FGFR30.52376387
77STK40.50593830
78DYRK30.50378551
79FGFR40.49514777
80STK240.45552886
81LRRK20.44881349
82TESK10.44040889
83PRKCQ0.43522880
84LATS20.43018770
85MOS0.42386708
86MAP3K30.41808942
87MAP2K60.41739331
88HIPK20.40404982
89ARAF0.40055336
90MAPKAPK20.37158082
91MAP3K10.36070941
92RPS6KC10.35512373
93RPS6KL10.35512373
94FYN0.34996464
95DAPK30.34985882
96SIK30.33847853
97PKN10.33540237
98ADRBK10.32395823
99MAPK70.30594410
100CAMKK20.30516901
101PAK40.29656405
102MAP3K110.28735478
103RIPK10.28025951
104PDK20.26981194
105IGF1R0.25932464
106PRKG20.24713272
107NLK0.23914616
108PDGFRA0.23679657
109INSR0.22577614
110PDK10.22564721
111RPS6KA60.21554401
112RPS6KA10.21453802
113PDPK10.20998383
114KSR20.20973097
115STK30.19993174
116TNK20.19255266
117GSK3A0.18764100
118PDGFRB0.18741160
119MAPK40.18078421
120MAP3K80.16917955
121SIK20.16366884
122CAMK1D0.15192586
123MAPK150.14795905
124CDK60.13712761
125PRKCH0.12839349

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.21283758
2Leishmaniasis_Homo sapiens_hsa051403.55834901
3Staphylococcus aureus infection_Homo sapiens_hsa051503.21516586
4Legionellosis_Homo sapiens_hsa051343.06047978
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.87512287
6Rheumatoid arthritis_Homo sapiens_hsa053232.82423735
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.80139955
8Type I diabetes mellitus_Homo sapiens_hsa049402.75712528
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.72764582
10Allograft rejection_Homo sapiens_hsa053302.71832609
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.57553840
12Malaria_Homo sapiens_hsa051442.54703451
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51491206
14Pertussis_Homo sapiens_hsa051332.43955935
15Osteoclast differentiation_Homo sapiens_hsa043802.38447513
16Tuberculosis_Homo sapiens_hsa051522.36337737
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.18625091
18Asthma_Homo sapiens_hsa053102.08022297
19TNF signaling pathway_Homo sapiens_hsa046682.03903651
20African trypanosomiasis_Homo sapiens_hsa051431.99126297
21Salmonella infection_Homo sapiens_hsa051321.96945142
22Measles_Homo sapiens_hsa051621.91234847
23Hematopoietic cell lineage_Homo sapiens_hsa046401.84718892
24Lysosome_Homo sapiens_hsa041421.71710540
25Influenza A_Homo sapiens_hsa051641.66568179
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63154839
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57652003
28Phagosome_Homo sapiens_hsa041451.56755681
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.51502266
30Toxoplasmosis_Homo sapiens_hsa051451.35099376
31Herpes simplex infection_Homo sapiens_hsa051681.31853856
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31771855
33B cell receptor signaling pathway_Homo sapiens_hsa046621.26469852
34Chemokine signaling pathway_Homo sapiens_hsa040621.25655355
35Apoptosis_Homo sapiens_hsa042101.19776856
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.18909800
37Amoebiasis_Homo sapiens_hsa051461.18071209
38Other glycan degradation_Homo sapiens_hsa005111.14378662
39Autoimmune thyroid disease_Homo sapiens_hsa053201.11634715
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08883121
41Antigen processing and presentation_Homo sapiens_hsa046121.05668676
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03934393
43Shigellosis_Homo sapiens_hsa051310.98217391
44Hepatitis B_Homo sapiens_hsa051610.95719309
45Prion diseases_Homo sapiens_hsa050200.95422918
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.90159488
47Hepatitis C_Homo sapiens_hsa051600.87212555
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85544910
49Complement and coagulation cascades_Homo sapiens_hsa046100.85291663
50Viral myocarditis_Homo sapiens_hsa054160.84718105
51Bladder cancer_Homo sapiens_hsa052190.82555368
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81707202
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80792431
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80309272
55T cell receptor signaling pathway_Homo sapiens_hsa046600.74505635
56Collecting duct acid secretion_Homo sapiens_hsa049660.71970915
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.68620801
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64019690
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.61197381
60Primary immunodeficiency_Homo sapiens_hsa053400.54862789
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51895966
62Sulfur metabolism_Homo sapiens_hsa009200.48040116
63Mineral absorption_Homo sapiens_hsa049780.46002622
64Type II diabetes mellitus_Homo sapiens_hsa049300.45899310
65Platelet activation_Homo sapiens_hsa046110.44571944
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.44369931
67Acute myeloid leukemia_Homo sapiens_hsa052210.43147499
68PPAR signaling pathway_Homo sapiens_hsa033200.43127405
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43112220
70Galactose metabolism_Homo sapiens_hsa000520.39048895
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.39047629
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36821030
73Epstein-Barr virus infection_Homo sapiens_hsa051690.36232375
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34859956
75Chronic myeloid leukemia_Homo sapiens_hsa052200.33724865
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33650428
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33558712
78Pancreatic cancer_Homo sapiens_hsa052120.31820640
79Prolactin signaling pathway_Homo sapiens_hsa049170.31240543
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28963834
81HIF-1 signaling pathway_Homo sapiens_hsa040660.27294484
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.26710363
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26656752
84Sphingolipid metabolism_Homo sapiens_hsa006000.26113895
85Fructose and mannose metabolism_Homo sapiens_hsa000510.25345996
86Small cell lung cancer_Homo sapiens_hsa052220.21853593
87Renal cell carcinoma_Homo sapiens_hsa052110.21421306
88Insulin resistance_Homo sapiens_hsa049310.20743278
89VEGF signaling pathway_Homo sapiens_hsa043700.19883457
90Systemic lupus erythematosus_Homo sapiens_hsa053220.19471923
91Vibrio cholerae infection_Homo sapiens_hsa051100.18410149
92Dorso-ventral axis formation_Homo sapiens_hsa043200.18140957
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16621317
94Viral carcinogenesis_Homo sapiens_hsa052030.16190527
95Tryptophan metabolism_Homo sapiens_hsa003800.15546833
96MAPK signaling pathway_Homo sapiens_hsa040100.15543890
97Proteoglycans in cancer_Homo sapiens_hsa052050.15292830
98FoxO signaling pathway_Homo sapiens_hsa040680.14087239
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12835250
100HTLV-I infection_Homo sapiens_hsa051660.11137207
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09764484
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09752029
103Endocytosis_Homo sapiens_hsa041440.09096003
104Notch signaling pathway_Homo sapiens_hsa043300.09080402
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09036860
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.07011037
107Ether lipid metabolism_Homo sapiens_hsa005650.04657950
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02558339
109Arachidonic acid metabolism_Homo sapiens_hsa005900.02388080
110Renin-angiotensin system_Homo sapiens_hsa046140.02297158
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.02067599

Most similar genes based on co-expression Upload to Enrichr

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