CCS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.51835231
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51835231
3L-phenylalanine metabolic process (GO:0006558)7.26873149
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26873149
5aromatic amino acid family catabolic process (GO:0009074)6.62320798
6tryptophan catabolic process (GO:0006569)5.85309609
7indole-containing compound catabolic process (GO:0042436)5.85309609
8indolalkylamine catabolic process (GO:0046218)5.85309609
9glyoxylate metabolic process (GO:0046487)5.78290612
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.67291089
11bile acid biosynthetic process (GO:0006699)5.67109749
12kynurenine metabolic process (GO:0070189)5.58884409
13tryptophan metabolic process (GO:0006568)5.53234523
14sulfur amino acid catabolic process (GO:0000098)5.29242533
15cysteine metabolic process (GO:0006534)5.25555603
16alpha-linolenic acid metabolic process (GO:0036109)5.05832927
17negative regulation of fibrinolysis (GO:0051918)5.04304790
18urea metabolic process (GO:0019627)4.99106431
19urea cycle (GO:0000050)4.99106431
20high-density lipoprotein particle remodeling (GO:0034375)4.98851498
21serine family amino acid catabolic process (GO:0009071)4.90732964
22protein carboxylation (GO:0018214)4.88156871
23peptidyl-glutamic acid carboxylation (GO:0017187)4.88156871
24aromatic amino acid family metabolic process (GO:0009072)4.86792699
25regulation of fibrinolysis (GO:0051917)4.84925348
26bile acid metabolic process (GO:0008206)4.75028342
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69388130
28regulation of protein activation cascade (GO:2000257)4.68245558
29nitrogen cycle metabolic process (GO:0071941)4.67145952
30complement activation, alternative pathway (GO:0006957)4.66207083
31regulation of cholesterol esterification (GO:0010872)4.64990437
32regulation of triglyceride catabolic process (GO:0010896)4.61821259
33homocysteine metabolic process (GO:0050667)4.58110936
34tyrosine metabolic process (GO:0006570)4.56408742
35alpha-amino acid catabolic process (GO:1901606)4.52442896
36aldehyde catabolic process (GO:0046185)4.50088286
37cellular ketone body metabolic process (GO:0046950)4.44615798
38amino-acid betaine metabolic process (GO:0006577)4.40022522
39lysine metabolic process (GO:0006553)4.38627841
40lysine catabolic process (GO:0006554)4.38627841
41regulation of complement activation (GO:0030449)4.37216870
42serine family amino acid biosynthetic process (GO:0009070)4.36928789
43glycine metabolic process (GO:0006544)4.36266063
44serine family amino acid metabolic process (GO:0009069)4.32242183
45reverse cholesterol transport (GO:0043691)4.27652280
46plasma lipoprotein particle remodeling (GO:0034369)4.24672804
47protein-lipid complex remodeling (GO:0034368)4.24672804
48macromolecular complex remodeling (GO:0034367)4.24672804
49coenzyme catabolic process (GO:0009109)4.21798001
50cellular amino acid catabolic process (GO:0009063)4.21724698
51triglyceride homeostasis (GO:0070328)4.18587899
52acylglycerol homeostasis (GO:0055090)4.18587899
53cellular biogenic amine catabolic process (GO:0042402)4.18234375
54amine catabolic process (GO:0009310)4.18234375
55indolalkylamine metabolic process (GO:0006586)4.17110488
56metallo-sulfur cluster assembly (GO:0031163)4.17078842
57iron-sulfur cluster assembly (GO:0016226)4.17078842
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.16611353
59phosphatidylglycerol biosynthetic process (GO:0006655)4.09309583
60negative regulation of cholesterol transport (GO:0032375)4.09275591
61negative regulation of sterol transport (GO:0032372)4.09275591
62imidazole-containing compound metabolic process (GO:0052803)4.02009084
63phospholipid efflux (GO:0033700)3.99632967
64ethanol oxidation (GO:0006069)3.98299042
65cellular glucuronidation (GO:0052695)3.97618682
66plasma lipoprotein particle clearance (GO:0034381)3.97050744
67autophagic vacuole fusion (GO:0000046)3.96859415
68bile acid and bile salt transport (GO:0015721)3.96597035
69cofactor catabolic process (GO:0051187)3.95650439
70benzene-containing compound metabolic process (GO:0042537)3.92208834
71cellular modified amino acid catabolic process (GO:0042219)3.89388257
72drug catabolic process (GO:0042737)3.86482331
73short-chain fatty acid metabolic process (GO:0046459)3.85139610
74glutamate metabolic process (GO:0006536)3.83477321
75ketone body metabolic process (GO:1902224)3.83298209
76arginine metabolic process (GO:0006525)3.80660599
77cholesterol efflux (GO:0033344)3.79137993
78fibrinolysis (GO:0042730)3.78752262
79carboxylic acid catabolic process (GO:0046395)3.75652902
80organic acid catabolic process (GO:0016054)3.75652902
81L-serine metabolic process (GO:0006563)3.67789309
82blood coagulation, intrinsic pathway (GO:0007597)3.66156486
83heme transport (GO:0015886)3.65954590
84positive regulation of lipoprotein lipase activity (GO:0051006)3.64745784
85positive regulation of triglyceride lipase activity (GO:0061365)3.64745784
86glucuronate metabolic process (GO:0019585)3.62701573
87uronic acid metabolic process (GO:0006063)3.62701573
88drug transmembrane transport (GO:0006855)3.62481438
89acetyl-CoA metabolic process (GO:0006084)3.61647911
90aspartate family amino acid catabolic process (GO:0009068)3.58273108
91plasma lipoprotein particle assembly (GO:0034377)3.56486794
92NAD biosynthetic process (GO:0009435)3.56454233
93very-low-density lipoprotein particle assembly (GO:0034379)3.56057728
94cholesterol homeostasis (GO:0042632)3.52252592
95urate metabolic process (GO:0046415)3.51814891
96low-density lipoprotein particle remodeling (GO:0034374)3.51037717
97nicotinamide nucleotide biosynthetic process (GO:0019359)3.49347304
98pyridine nucleotide biosynthetic process (GO:0019363)3.49347304
99response to nitrosative stress (GO:0051409)3.49096563
100fatty acid beta-oxidation (GO:0006635)3.47334252
101exogenous drug catabolic process (GO:0042738)3.46750683
102very long-chain fatty acid metabolic process (GO:0000038)3.45982071
103drug metabolic process (GO:0017144)3.45157536
104sterol homeostasis (GO:0055092)3.44912908
105regulation of bile acid biosynthetic process (GO:0070857)3.43942171
106response to misfolded protein (GO:0051788)3.34055511
107protein complex biogenesis (GO:0070271)3.23652321
108purine deoxyribonucleotide catabolic process (GO:0009155)3.22801070
109deoxyribonucleotide catabolic process (GO:0009264)3.20626288
110cytochrome complex assembly (GO:0017004)3.20184279
111purine deoxyribonucleotide metabolic process (GO:0009151)3.09786283
112seminiferous tubule development (GO:0072520)3.08683957
113valine metabolic process (GO:0006573)3.03490410
114mitochondrial calcium ion transport (GO:0006851)3.02928092
115base-excision repair, AP site formation (GO:0006285)2.93318377
116arginine catabolic process (GO:0006527)2.91437235
117regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.89352787
118deoxyribose phosphate catabolic process (GO:0046386)2.88142308
119heme metabolic process (GO:0042168)2.86811610
120purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.85740312
121organelle membrane fusion (GO:0090174)2.79178070
122xenobiotic catabolic process (GO:0042178)2.78801045
123mannosylation (GO:0097502)2.78527343
124mitochondrial respiratory chain complex assembly (GO:0033108)2.78477711
125positive regulation of mitochondrial fission (GO:0090141)2.78431157
126heme biosynthetic process (GO:0006783)2.78420779
127GDP-mannose metabolic process (GO:0019673)2.76594947
128cholesterol catabolic process (GO:0006707)2.76435190
129sterol catabolic process (GO:0016127)2.76435190
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.75729947
131NADH dehydrogenase complex assembly (GO:0010257)2.75729947
132mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75729947
133respiratory chain complex IV assembly (GO:0008535)2.68244392
134negative regulation of B cell apoptotic process (GO:0002903)2.67378693
135response to interferon-beta (GO:0035456)2.63039033
136porphyrin-containing compound metabolic process (GO:0006778)2.62901994
137phosphatidylethanolamine biosynthetic process (GO:0006646)2.62784874
138porphyrin-containing compound biosynthetic process (GO:0006779)2.60710745
139regulation of cytokine secretion involved in immune response (GO:0002739)2.59056056
140pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58282455
141immunoglobulin mediated immune response (GO:0016064)2.56804500
142protoporphyrinogen IX biosynthetic process (GO:0006782)2.56166767
143hemoglobin metabolic process (GO:0020027)2.54519537
144Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54369961
1452-deoxyribonucleotide metabolic process (GO:0009394)2.53000652
146deoxyribose phosphate metabolic process (GO:0019692)2.52911403
147regulation of B cell apoptotic process (GO:0002902)2.52543197
148protoporphyrinogen IX metabolic process (GO:0046501)2.51051104
149purine nucleotide salvage (GO:0032261)2.50082354
150positive regulation of megakaryocyte differentiation (GO:0045654)2.49995231
151deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.48297206
152DNA deamination (GO:0045006)2.47637656
153branched-chain amino acid catabolic process (GO:0009083)2.46774564
154tetrapyrrole biosynthetic process (GO:0033014)2.45783208
155phenylpropanoid metabolic process (GO:0009698)2.45103594
156plasma lipoprotein particle organization (GO:0071827)2.44022606
157misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.42591577
158negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.41622261
159purine-containing compound salvage (GO:0043101)2.41449221
160S-adenosylmethionine metabolic process (GO:0046500)2.39988477
161positive regulation of fatty acid biosynthetic process (GO:0045723)2.39765372
162preassembly of GPI anchor in ER membrane (GO:0016254)2.38082104
163glutathione biosynthetic process (GO:0006750)2.37473302
164branched-chain amino acid metabolic process (GO:0009081)2.37051952
165glutathione metabolic process (GO:0006749)2.35542587
166positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.34354395
167ubiquinone biosynthetic process (GO:0006744)2.34269464
168glutathione derivative biosynthetic process (GO:1901687)2.33433606
169glutathione derivative metabolic process (GO:1901685)2.33433606
170phosphatidylcholine biosynthetic process (GO:0006656)2.31469199
171regulation of mitochondrial fission (GO:0090140)2.31055834
172phosphatidylethanolamine metabolic process (GO:0046337)2.30859047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.60595265
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.69566887
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.59363555
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.68692731
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.34957979
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80360962
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.65080758
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.23260861
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56684291
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09859453
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.44548764
12* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42593044
13BCL6_27268052_Chip-Seq_Bcells_Human2.34845344
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29580005
15* ELF1_20517297_ChIP-Seq_JURKAT_Human2.25126145
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.23377216
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14746234
18SCL_19346495_ChIP-Seq_HPC-7_Human2.09575297
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04977901
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02184171
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0884355
22VDR_21846776_ChIP-Seq_THP-1_Human1.96041440
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93436781
24YY1_22570637_ChIP-Seq_MALME-3M_Human1.85233157
25* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74844823
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73073218
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71712993
28* P68_20966046_ChIP-Seq_HELA_Human1.71297441
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70415285
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68939017
31* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68837604
32* PHF8_20622854_ChIP-Seq_HELA_Human1.58717298
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58529300
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56370801
35CTCF_26484167_Chip-Seq_Bcells_Mouse1.52284442
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49832765
37* E2F1_20622854_ChIP-Seq_HELA_Human1.49155051
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49135136
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.46721072
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45590484
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42551436
42* P300_27268052_Chip-Seq_Bcells_Human1.42408347
43HTT_18923047_ChIP-ChIP_STHdh_Human1.40851717
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40486288
45GABP_19822575_ChIP-Seq_HepG2_Human1.38316674
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38054069
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36232580
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36143434
49* ERA_21632823_ChIP-Seq_H3396_Human1.33444221
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32419555
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30963968
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30299231
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.29443812
54VDR_23849224_ChIP-Seq_CD4+_Human1.29276834
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27566842
56VDR_24763502_ChIP-Seq_THP-1_Human1.27465799
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25884137
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.25034700
59UTX_26944678_Chip-Seq_JUKART_Human1.24905991
60* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24461066
61ZNF274_21170338_ChIP-Seq_K562_Hela1.24291894
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23809534
63CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23675014
64CLOCK_20551151_ChIP-Seq_293T_Human1.23612034
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21315722
66SPI1_23547873_ChIP-Seq_NB4_Human1.20177175
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.19835858
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.19502380
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.18661430
70STAT1_20625510_ChIP-Seq_HELA_Human1.18041260
71FOXP3_21729870_ChIP-Seq_TREG_Human1.16977835
72HNF4A_19822575_ChIP-Seq_HepG2_Human1.15182619
73RAC3_21632823_ChIP-Seq_H3396_Human1.15015931
74GATA1_22025678_ChIP-Seq_K562_Human1.14640591
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14453003
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13978524
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.13735724
78CIITA_25753668_ChIP-Seq_RAJI_Human1.13580863
79GATA1_19941826_ChIP-Seq_K562_Human1.12547446
80MAF_26560356_Chip-Seq_TH2_Human1.12027033
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11908397
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11202509
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10167904
84SA1_27219007_Chip-Seq_Bcells_Human1.10083928
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.09523017
86SPI1_20517297_ChIP-Seq_HL60_Human1.09435290
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08250707
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07441253
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05863709
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.05496807
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05101893
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04740994
93SPI1_23127762_ChIP-Seq_K562_Human1.04630044
94LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04362729
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02351195
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02225358
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01894785
98ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97855259
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97581667
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92323805
101GABP_17652178_ChIP-ChIP_JURKAT_Human0.91709651
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90287737
103KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88734311
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86018138
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84317912
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84251559
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83442877
108GATA4_25053715_ChIP-Seq_YYC3_Human0.82848582
109CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82162715
110* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.80540378
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78635940
112RARB_24833708_ChIP-Seq_LIVER_Mouse0.78626447
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78204856
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77527020
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75855357
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.75398029
117EST1_17652178_ChIP-ChIP_JURKAT_Human0.74870027
118IRF1_19129219_ChIP-ChIP_H3396_Human0.73555375
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69216006
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67742707
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67407204
122AR_20517297_ChIP-Seq_VCAP_Human0.66673903
123* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.66328509
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65146253
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.60942846
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60767834
127CEBPB_22108803_ChIP-Seq_LS180_Human0.60566705
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.60361991
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.58610379
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.57900097
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.57779260
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57457325
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57305772
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.56138721
135MYC_19915707_ChIP-ChIP_AK7_Human0.55936708
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.55913655
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.55301762
138ETS1_20019798_ChIP-Seq_JURKAT_Human0.52744597
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.52151022
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.51668762
141EGR1_19032775_ChIP-ChIP_M12_Human0.51230168
142CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.51205675
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51104262
144NANOG_20526341_ChIP-Seq_ESCs_Human0.50986402
145CTCF_20526341_ChIP-Seq_ESCs_Human0.50548876
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.50259050
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.50258610
148ERG_20517297_ChIP-Seq_VCAP_Human0.49659051
149P53_21459846_ChIP-Seq_SAOS-2_Human0.49365837
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.48168593
151SOX2_22085726_ChIP-Seq_NPCs_Mouse0.48054192
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.47947440
153LXR_22292898_ChIP-Seq_THP-1_Human0.47910883
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.47637452
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.47637452
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.47615169
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47234771
158TAF2_19829295_ChIP-Seq_ESCs_Human0.46456870
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46347195
160* BCOR_27268052_Chip-Seq_Bcells_Human0.46270165
161* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.46103927
162CSB_26484114_Chip-Seq_FIBROBLAST_Human0.46084287
163PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45917926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.84348603
2MP0005360_urolithiasis7.31542273
3MP0005085_abnormal_gallbladder_physiolo6.01313380
4MP0005365_abnormal_bile_salt5.85444706
5MP0003806_abnormal_nucleotide_metabolis5.12515328
6MP0008875_abnormal_xenobiotic_pharmacok5.05210614
7MP0003252_abnormal_bile_duct3.56499342
8MP0010329_abnormal_lipoprotein_level3.23347097
9MP0009840_abnormal_foam_cell3.00425810
10MP0005332_abnormal_amino_acid2.96096311
11MP0003195_calcinosis2.93825528
12MP0009278_abnormal_bone_marrow2.83917389
13MP0005083_abnormal_biliary_tract2.75471966
14MP0001666_abnormal_nutrient_absorption2.54170659
15MP0001986_abnormal_taste_sensitivity2.45166096
16MP0001545_abnormal_hematopoietic_system2.42944786
17MP0005397_hematopoietic_system_phenotyp2.42944786
18MP0003172_abnormal_lysosome_physiology2.34410080
19MP0004019_abnormal_vitamin_homeostasis2.30217699
20MP0003191_abnormal_cellular_cholesterol2.24287724
21MP0000609_abnormal_liver_physiology2.02562494
22MP0002138_abnormal_hepatobiliary_system2.01973796
23MP0002118_abnormal_lipid_homeostasis1.96341956
24MP0003186_abnormal_redox_activity1.94267092
25MP0000465_gastrointestinal_hemorrhage1.86957163
26MP0001764_abnormal_homeostasis1.83025100
27MP0005319_abnormal_enzyme/_coenzyme1.82480018
28MP0005646_abnormal_pituitary_gland1.78117124
29MP0005451_abnormal_body_composition1.70739952
30MP0003011_delayed_dark_adaptation1.67778353
31MP0002837_dystrophic_cardiac_calcinosis1.66957817
32MP0003868_abnormal_feces_composition1.66013352
33MP0008995_early_reproductive_senescence1.63819812
34MP0005645_abnormal_hypothalamus_physiol1.59720952
35* MP0005584_abnormal_enzyme/coenzyme_acti1.58570681
36MP0002653_abnormal_ependyma_morphology1.53653245
37MP0009697_abnormal_copulation1.52102561
38MP0009643_abnormal_urine_homeostasis1.51039940
39MP0003656_abnormal_erythrocyte_physiolo1.49420751
40MP0002148_abnormal_hypersensitivity_rea1.43613693
41MP0008260_abnormal_autophagy1.43156835
42MP0002419_abnormal_innate_immunity1.36220680
43MP0005387_immune_system_phenotype1.33884796
44MP0001790_abnormal_immune_system1.33884796
45MP0001873_stomach_inflammation1.33045571
46MP0005000_abnormal_immune_tolerance1.27158143
47MP0001800_abnormal_humoral_immune1.23328278
48MP0002723_abnormal_immune_serum1.22944833
49MP0005671_abnormal_response_to1.22944043
50MP0006036_abnormal_mitochondrial_physio1.19578690
51MP0000598_abnormal_liver_morphology1.17486013
52MP0001835_abnormal_antigen_presentation1.15237728
53* MP0005636_abnormal_mineral_homeostasis1.13477402
54MP0003303_peritoneal_inflammation1.12229185
55MP0002452_abnormal_antigen_presenting1.11354796
56MP0001968_abnormal_touch/_nociception1.11285699
57MP0002420_abnormal_adaptive_immunity1.10241612
58MP0000689_abnormal_spleen_morphology1.09513507
59MP0001819_abnormal_immune_cell1.09101736
60MP0009764_decreased_sensitivity_to1.07747241
61MP0002822_catalepsy1.07385918
62MP0005408_hypopigmentation1.04960982
63MP0001533_abnormal_skeleton_physiology1.03436260
64MP0005410_abnormal_fertilization1.03365875
65MP0008469_abnormal_protein_level1.01092018
66MP0009763_increased_sensitivity_to1.00903805
67MP0003724_increased_susceptibility_to1.00649714
68MP0005647_abnormal_sex_gland1.00587187
69MP0005551_abnormal_eye_electrophysiolog0.99738358
70MP0000685_abnormal_immune_system0.97760164
71MP0005084_abnormal_gallbladder_morpholo0.95352746
72MP0000604_amyloidosis0.93715216
73MP0003786_premature_aging0.93415362
74MP0002405_respiratory_system_inflammati0.92897494
75MP0005670_abnormal_white_adipose0.92195396
76MP0001905_abnormal_dopamine_level0.92151432
77MP0001529_abnormal_vocalization0.91771477
78MP0002933_joint_inflammation0.88306105
79MP0010368_abnormal_lymphatic_system0.87903782
80MP0009642_abnormal_blood_homeostasis0.86695248
81MP0005376_homeostasis/metabolism_phenot0.86391447
82MP0002876_abnormal_thyroid_physiology0.85479856
83MP0005220_abnormal_exocrine_pancreas0.85263024
84MP0002722_abnormal_immune_system0.85034134
85MP0000372_irregular_coat_pigmentation0.83987776
86MP0000716_abnormal_immune_system0.83749658
87MP0000516_abnormal_urinary_system0.83145927
88MP0005367_renal/urinary_system_phenotyp0.83145927
89MP0009765_abnormal_xenobiotic_induced0.81681692
90MP0002693_abnormal_pancreas_physiology0.78809189
91MP0003690_abnormal_glial_cell0.78662071
92MP0002429_abnormal_blood_cell0.77347240
93MP0001661_extended_life_span0.76997358
94MP0001756_abnormal_urination0.76933434
95MP0002909_abnormal_adrenal_gland0.76690594
96MP0002132_abnormal_respiratory_system0.76167247
97MP0002254_reproductive_system_inflammat0.75707066
98MP0006035_abnormal_mitochondrial_morpho0.73634019
99MP0006082_CNS_inflammation0.73157320
100MP0005266_abnormal_metabolism0.72812147
101MP0003718_maternal_effect0.69153562
102MP0004043_abnormal_pH_regulation0.65602809
103MP0004147_increased_porphyrin_level0.65013402
104MP0002136_abnormal_kidney_physiology0.63404909
105MP0004381_abnormal_hair_follicle0.62823851
106MP0005058_abnormal_lysosome_morphology0.60667596
107MP0002078_abnormal_glucose_homeostasis0.59595065
108MP0003329_amyloid_beta_deposits0.57858116
109MP0003705_abnormal_hypodermis_morpholog0.57303750
110MP0005395_other_phenotype0.55414790
111MP0003638_abnormal_response/metabolism_0.55268614
112MP0009379_abnormal_foot_pigmentation0.55121437
113MP0009053_abnormal_anal_canal0.54933406
114MP0008873_increased_physiological_sensi0.53304832
115MP0004782_abnormal_surfactant_physiolog0.53291626
116MP0005334_abnormal_fat_pad0.51158050
117MP0005535_abnormal_body_temperature0.50983623
118MP0001853_heart_inflammation0.50919926
119MP0002971_abnormal_brown_adipose0.50180299
120MP0005464_abnormal_platelet_physiology0.47281348
121MP0000639_abnormal_adrenal_gland0.47041697
122MP0008872_abnormal_physiological_respon0.43681946
123MP0003436_decreased_susceptibility_to0.41879441
124MP0001243_abnormal_dermal_layer0.40562959
125MP0001845_abnormal_inflammatory_respons0.39696744
126MP0009384_cardiac_valve_regurgitation0.39166477
127MP0004130_abnormal_muscle_cell0.39014294
128MP0009785_altered_susceptibility_to0.38162715
129MP0001542_abnormal_bone_strength0.37281978
130MP0002796_impaired_skin_barrier0.36504177
131MP0005075_abnormal_melanosome_morpholog0.34649448
132MP0003075_altered_response_to0.34549378
133MP0000230_abnormal_systemic_arterial0.34457642
134MP0000566_synostosis0.34249067
135MP0005166_decreased_susceptibility_to0.34120071
136MP0005448_abnormal_energy_balance0.33719278
137MP0002295_abnormal_pulmonary_circulatio0.32692879
138MP0005025_abnormal_response_to0.31594805
139MP0003953_abnormal_hormone_level0.30371963
140MP0005666_abnormal_adipose_tissue0.30093491
141MP0002060_abnormal_skin_morphology0.29804965
142MP0001765_abnormal_ion_homeostasis0.29203805
143MP0000249_abnormal_blood_vessel0.28846099
144MP0000920_abnormal_myelination0.28379609
145MP0005164_abnormal_response_to0.28337262
146MP0002168_other_aberrant_phenotype0.27216657

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31706750
2Intrahepatic cholestasis (HP:0001406)6.65704430
3Deep venous thrombosis (HP:0002625)6.26138187
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.04489005
5Prolonged partial thromboplastin time (HP:0003645)5.83633062
6Hypobetalipoproteinemia (HP:0003563)5.81361155
7Xanthomatosis (HP:0000991)5.55803505
8Hyperlipoproteinemia (HP:0010980)4.94371302
9Hyperammonemia (HP:0001987)4.48735484
10Complement deficiency (HP:0004431)4.39570212
11Hyperglycinemia (HP:0002154)4.36782443
12Hypolipoproteinemia (HP:0010981)4.19005264
13Hepatocellular necrosis (HP:0001404)4.17597663
14Abnormality of methionine metabolism (HP:0010901)4.06396460
15Joint hemorrhage (HP:0005261)4.05651591
16Abnormality of glycine metabolism (HP:0010895)4.04060670
17Abnormality of serine family amino acid metabolism (HP:0010894)4.04060670
18Hyperglycinuria (HP:0003108)4.01033269
19Ketosis (HP:0001946)4.00220028
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.98983538
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95601293
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.92905272
23Fat malabsorption (HP:0002630)3.92763228
24Petechiae (HP:0000967)3.88801387
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.86341293
26Abnormality of fatty-acid metabolism (HP:0004359)3.86053362
27Hypoglycemic coma (HP:0001325)3.85485307
28Epidermoid cyst (HP:0200040)3.80544205
29Abnormality of the common coagulation pathway (HP:0010990)3.70231391
30Mitochondrial inheritance (HP:0001427)3.59917770
31Abnormality of pyrimidine metabolism (HP:0004353)3.59527788
32Abnormality of the heme biosynthetic pathway (HP:0010472)3.55693764
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.53950544
34Delayed CNS myelination (HP:0002188)3.53181834
35Abnormal mitochondria in muscle tissue (HP:0008316)3.50771900
36Hypoalphalipoproteinemia (HP:0003233)3.49675015
37Conjugated hyperbilirubinemia (HP:0002908)3.44586429
38Abnormality of the intrinsic pathway (HP:0010989)3.32159961
39Hyperbilirubinemia (HP:0002904)3.29735494
40Cerebral edema (HP:0002181)3.26773311
41Steatorrhea (HP:0002570)3.21197889
42Abnormality of complement system (HP:0005339)3.17962683
43Abnormality of serum amino acid levels (HP:0003112)3.14959870
44Acute necrotizing encephalopathy (HP:0006965)3.12158054
45Cerebral palsy (HP:0100021)3.10423226
46Lethargy (HP:0001254)3.09275268
47Abnormality of dicarboxylic acid metabolism (HP:0010995)3.07730768
48Dicarboxylic aciduria (HP:0003215)3.07730768
49Hypercholesterolemia (HP:0003124)3.00158492
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.99571058
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.99571058
52Increased CSF lactate (HP:0002490)2.97205119
53Abnormality of nucleobase metabolism (HP:0010932)2.96902477
54Metabolic acidosis (HP:0001942)2.95129872
55Obstructive lung disease (HP:0006536)2.91450107
56Chronic obstructive pulmonary disease (HP:0006510)2.91450107
57Increased muscle lipid content (HP:0009058)2.88082034
58Increased intramyocellular lipid droplets (HP:0012240)2.81543387
59Elevated erythrocyte sedimentation rate (HP:0003565)2.80568976
60Ketoacidosis (HP:0001993)2.77960188
61Ragged-red muscle fibers (HP:0003200)2.76860740
62Prolonged bleeding time (HP:0003010)2.76713851
63Purpura (HP:0000979)2.71743625
64Retinal atrophy (HP:0001105)2.70731719
65Generalized aminoaciduria (HP:0002909)2.67959522
66Acute encephalopathy (HP:0006846)2.65970471
67Abnormality of purine metabolism (HP:0004352)2.65589822
68Vacuolated lymphocytes (HP:0001922)2.64228349
69Epistaxis (HP:0000421)2.63797800
70Agammaglobulinemia (HP:0004432)2.63563166
71Hepatocellular carcinoma (HP:0001402)2.61904320
72Vascular calcification (HP:0004934)2.58814699
73Progressive macrocephaly (HP:0004481)2.48378938
74Abnormality of liposaccharide metabolism (HP:0010968)2.48280905
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.48280905
76Abnormality of glycolipid metabolism (HP:0010969)2.48280905
77Vomiting (HP:0002013)2.47094756
78Lactic acidosis (HP:0003128)2.46770312
79Opisthotonus (HP:0002179)2.44991912
80Gout (HP:0001997)2.44801401
81Stomatitis (HP:0010280)2.41242246
82Brushfield spots (HP:0001088)2.41189132
83Spontaneous abortion (HP:0005268)2.40442256
84Glycosuria (HP:0003076)2.37668716
85Abnormality of urine glucose concentration (HP:0011016)2.37668716
86Abnormal gallbladder morphology (HP:0012437)2.36091768
87Hypoglycemic seizures (HP:0002173)2.35807355
88Dysostosis multiplex (HP:0000943)2.35172507
89Irritability (HP:0000737)2.34809773
90Prolonged neonatal jaundice (HP:0006579)2.33561077
91Spastic diplegia (HP:0001264)2.30641088
92Systemic lupus erythematosus (HP:0002725)2.28931086
93Malnutrition (HP:0004395)2.28628844
94Severe visual impairment (HP:0001141)2.28554887
95Hepatic necrosis (HP:0002605)2.27315343
96Progressive microcephaly (HP:0000253)2.26799264
97Skin nodule (HP:0200036)2.26537499
98Acanthocytosis (HP:0001927)2.26488938
99Increased serum lactate (HP:0002151)2.26051301
100Cardiovascular calcification (HP:0011915)2.25999753
101Cholelithiasis (HP:0001081)2.24906223
102Amyloidosis (HP:0011034)2.24844114
103Myocardial infarction (HP:0001658)2.21580915
104Increased serum ferritin (HP:0003281)2.21087539
105Myositis (HP:0100614)2.20556959
106Panhypogammaglobulinemia (HP:0003139)2.20536887
107Abnormal gallbladder physiology (HP:0012438)2.20485024
108Cholecystitis (HP:0001082)2.20485024
109Hypochromic microcytic anemia (HP:0004840)2.20356679
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19563068
111Enlarged kidneys (HP:0000105)2.17436693
112Renal cortical cysts (HP:0000803)2.17225129
113Abnormality of the prostate (HP:0008775)2.16401923
114Proximal tubulopathy (HP:0000114)2.15807490
115Hepatosplenomegaly (HP:0001433)2.14835409
116Alkalosis (HP:0001948)2.14375974
117Pancreatitis (HP:0001733)2.14204225
118Renal Fanconi syndrome (HP:0001994)2.13281560
119Abnormal pupillary function (HP:0007686)2.12943009
120Tubulointerstitial nephritis (HP:0001970)2.12069837
121Abnormality of polysaccharide metabolism (HP:0011012)2.10611400
122Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10611400
123Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10611400
124Emotional lability (HP:0000712)2.08777677
125Increased neuronal autofluorescent lipopigment (HP:0002074)2.08667679
1263-Methylglutaconic aciduria (HP:0003535)2.08574589
127J-shaped sella turcica (HP:0002680)2.07380582
128Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06157963
129Neonatal onset (HP:0003623)2.04728209
130Increased serum pyruvate (HP:0003542)2.04309239
131Abnormality of glycolysis (HP:0004366)2.04309239
132Bile duct proliferation (HP:0001408)2.01438382
133Abnormal biliary tract physiology (HP:0012439)2.01438382
134Increased cerebral lipofuscin (HP:0011813)2.00787277
135Mesangial abnormality (HP:0001966)2.00542938
136Episodic fever (HP:0001954)1.99469033
137Recurrent gram-negative bacterial infections (HP:0005420)1.98694915
138Glomerulonephritis (HP:0000099)1.98063207
139Rickets (HP:0002748)1.95861970
140Respiratory failure (HP:0002878)1.95625904
141Abnormal enzyme/coenzyme activity (HP:0012379)1.95624460
142Stridor (HP:0010307)1.95482950
143Progressive neurologic deterioration (HP:0002344)1.95451971
144Abnormal cartilage morphology (HP:0002763)1.95146717
145Spastic paraparesis (HP:0002313)1.94706403
146Loss of speech (HP:0002371)1.94214262
147Abnormality of iron homeostasis (HP:0011031)1.92447296
148Elevated hepatic transaminases (HP:0002910)1.91129232
149Gingival bleeding (HP:0000225)1.90872514
150Nausea (HP:0002018)1.89835957
151Recurrent fungal infections (HP:0002841)1.89476166
152Abnormality of transition element cation homeostasis (HP:0011030)1.89310352
153Mitral stenosis (HP:0001718)1.88668163
154Mediastinal lymphadenopathy (HP:0100721)1.87906407
155CNS demyelination (HP:0007305)1.87518433
156Abnormality of the gallbladder (HP:0005264)1.87505991
157Menorrhagia (HP:0000132)1.87489185
158Recurrent abscess formation (HP:0002722)1.86611071
159Poikilocytosis (HP:0004447)1.85407761
160Skin rash (HP:0000988)1.84958107
161Hyperinsulinemic hypoglycemia (HP:0000825)1.84439402
162Abnormality of macrophages (HP:0004311)1.84432257
163Abnormality of lateral ventricle (HP:0030047)1.83575736
164Hypophosphatemic rickets (HP:0004912)1.83212861
165Abnormality of vitamin metabolism (HP:0100508)1.82996138
166Exercise intolerance (HP:0003546)1.82585922
167Methylmalonic aciduria (HP:0012120)1.80652492
168Urinary glycosaminoglycan excretion (HP:0003541)1.80522642
169Mucopolysacchariduria (HP:0008155)1.80522642
170Meningitis (HP:0001287)1.80478854
171Hyperthyroidism (HP:0000836)1.77754469
172Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77585832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.17574613
2ERN14.10227276
3FGFR44.01122201
4MAP4K23.25798586
5SIK13.06246338
6VRK22.85877500
7TNK22.83347661
8NME22.72624326
9TIE12.49433175
10KDR2.36173191
11CDK192.34894185
12STK162.32550195
13PIK3CG2.19657088
14ERBB42.18919611
15PBK2.11368618
16IRAK32.09569876
17FLT31.97532663
18TYK21.93343338
19CCNB11.93237361
20WNK41.91931732
21INSRR1.91165456
22ABL21.88217428
23MST1R1.64276979
24TAOK31.62873275
25MAPK111.56204895
26DAPK11.48731942
27RIPK41.46646851
28MET1.39416482
29TBK11.37677003
30OXSR11.37570243
31TESK11.33135048
32STK391.30533559
33MAPK151.27535012
34MYLK1.21520945
35EIF2AK11.21266206
36IKBKE1.19342357
37SYK1.16950386
38MAP3K31.14241651
39NEK91.12202498
40TESK21.10968258
41FES1.08525058
42MATK1.04854166
43PRKD21.04577116
44MAPKAPK31.03755700
45EPHB10.99935175
46PINK10.97244775
47MAPK40.96545538
48CAMK2G0.93832935
49IRAK20.93387801
50NUAK10.93369536
51GRK50.91373743
52GRK60.89977543
53MAP2K20.89048321
54BLK0.86788828
55KIT0.85194466
56STK38L0.83841518
57JAK20.79672233
58MAP2K60.79563576
59MAP3K110.78398614
60ZAK0.78000484
61ERBB20.77669718
62MAP3K140.77277891
63MAP2K40.76267143
64EIF2AK30.75537492
65TLK10.72386846
66TAOK10.71777038
67GRK70.70771978
68IRAK10.70647867
69CSNK1G10.70282351
70CSNK1G30.70072856
71BMX0.70068610
72PIM20.69066451
73LCK0.68812917
74MAP3K10.68777469
75GRK10.67533492
76MAP3K70.66812700
77BUB10.66735331
78CSNK1G20.66339417
79PIK3CA0.66011458
80HIPK20.65399189
81MAPK120.65062350
82PTK2B0.64822398
83VRK10.63394393
84GSK3A0.61003603
85IKBKB0.60417643
86MAP4K10.60409762
87PRKCZ0.59970935
88SIK20.59948756
89PDK10.58968746
90PIM10.58542477
91RPS6KA40.58015678
92DYRK1B0.56442163
93IRAK40.55469003
94PDPK10.55242346
95FRK0.53952126
96TAOK20.53292252
97CSK0.53251261
98PRKCQ0.53206798
99MAPK70.53141454
100MAPK130.53092136
101PTK60.52893069
102RPS6KA50.52527370
103PRKAA20.52065082
104PRKACG0.51462237
105PKN10.50523897
106EPHA20.49945715
107MAP2K30.48784310
108TGFBR20.47112323
109CSF1R0.46613428
110MAPKAPK20.46493756
111LRRK20.46262798
112ADRBK10.45732808
113FGFR20.45444448
114ITK0.44588747
115ACVR1B0.44365221
116CSNK1A10.43515737
117TXK0.41921735
118PRKG20.40246429
119JAK10.39284758
120TEC0.38365011
121RPS6KA60.37779785
122NME10.37743406
123ADRBK20.37190451
124PRKCD0.36835028
125MAP2K70.36507468
126RPS6KC10.36056258
127RPS6KL10.36056258
128MAPK30.35713146
129IGF1R0.35546571
130JAK30.35069046
131CSNK2A10.34529809
132DAPK30.34140390
133CSNK1A1L0.33599796
134LYN0.32211273
135ZAP700.32113005
136PDK20.31163825
137DAPK20.30464063
138PDK30.29773089
139PDK40.29773089
140BTK0.29739857
141PKN20.28611054
142LATS10.28488930
143MAP2K10.26337266
144DYRK20.25771280
145PRKCA0.25537205
146BCR0.24945961

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06243786
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07699857
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87625452
4Nitrogen metabolism_Homo sapiens_hsa009102.87327253
5Arginine biosynthesis_Homo sapiens_hsa002202.75242605
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70033611
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67498354
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67058722
9Tryptophan metabolism_Homo sapiens_hsa003802.52798358
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52184279
11Fatty acid degradation_Homo sapiens_hsa000712.37900979
12Complement and coagulation cascades_Homo sapiens_hsa046102.34124957
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20233800
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19248631
15Peroxisome_Homo sapiens_hsa041462.19223966
16Butanoate metabolism_Homo sapiens_hsa006502.15128114
17Propanoate metabolism_Homo sapiens_hsa006402.03935183
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98395141
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97509078
20Histidine metabolism_Homo sapiens_hsa003401.97088514
21Chemical carcinogenesis_Homo sapiens_hsa052041.96858930
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.85737155
23Primary immunodeficiency_Homo sapiens_hsa053401.79065764
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77185146
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75498671
26Caffeine metabolism_Homo sapiens_hsa002321.75006639
27Fatty acid elongation_Homo sapiens_hsa000621.74469858
28Fatty acid metabolism_Homo sapiens_hsa012121.74200991
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73315424
30PPAR signaling pathway_Homo sapiens_hsa033201.73291216
31Sulfur metabolism_Homo sapiens_hsa009201.71381583
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68295166
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68168120
34beta-Alanine metabolism_Homo sapiens_hsa004101.66732468
35Retinol metabolism_Homo sapiens_hsa008301.61083901
36Folate biosynthesis_Homo sapiens_hsa007901.58564061
37Steroid biosynthesis_Homo sapiens_hsa001001.57665055
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54457073
39Phenylalanine metabolism_Homo sapiens_hsa003601.53469566
40Selenocompound metabolism_Homo sapiens_hsa004501.48060842
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47438555
42Pyruvate metabolism_Homo sapiens_hsa006201.47073408
43Asthma_Homo sapiens_hsa053101.44563337
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.43947608
45Tyrosine metabolism_Homo sapiens_hsa003501.41800376
46Staphylococcus aureus infection_Homo sapiens_hsa051501.41329195
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.41132755
48Base excision repair_Homo sapiens_hsa034101.32891117
49Biosynthesis of amino acids_Homo sapiens_hsa012301.30400062
50Carbon metabolism_Homo sapiens_hsa012001.23812837
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23384563
52Sulfur relay system_Homo sapiens_hsa041221.23085941
53Bile secretion_Homo sapiens_hsa049761.23020222
54Collecting duct acid secretion_Homo sapiens_hsa049661.17291328
55Arginine and proline metabolism_Homo sapiens_hsa003301.17236261
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.15593369
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14896160
58Lysosome_Homo sapiens_hsa041421.13586658
59Type I diabetes mellitus_Homo sapiens_hsa049401.11937915
60Autoimmune thyroid disease_Homo sapiens_hsa053201.10170759
61Allograft rejection_Homo sapiens_hsa053301.06933160
62Starch and sucrose metabolism_Homo sapiens_hsa005001.06272265
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03088680
64Glutathione metabolism_Homo sapiens_hsa004801.02993443
65Fat digestion and absorption_Homo sapiens_hsa049751.01426803
66Vitamin B6 metabolism_Homo sapiens_hsa007501.00687432
67ABC transporters_Homo sapiens_hsa020100.99740186
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99367208
69Rheumatoid arthritis_Homo sapiens_hsa053230.95812020
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.94123537
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93018018
72Vitamin digestion and absorption_Homo sapiens_hsa049770.92304201
73Graft-versus-host disease_Homo sapiens_hsa053320.88898500
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80737309
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79117901
76One carbon pool by folate_Homo sapiens_hsa006700.77631285
77Pentose phosphate pathway_Homo sapiens_hsa000300.74158486
78Homologous recombination_Homo sapiens_hsa034400.73373384
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72334481
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71202260
81Metabolic pathways_Homo sapiens_hsa011000.67462972
82Hematopoietic cell lineage_Homo sapiens_hsa046400.65098365
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63724762
84N-Glycan biosynthesis_Homo sapiens_hsa005100.63295589
85Oxidative phosphorylation_Homo sapiens_hsa001900.59250223
86Glycerolipid metabolism_Homo sapiens_hsa005610.55972762
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52065541
88RNA polymerase_Homo sapiens_hsa030200.51508793
89Antigen processing and presentation_Homo sapiens_hsa046120.50739961
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50663933
91Lysine degradation_Homo sapiens_hsa003100.50177361
92African trypanosomiasis_Homo sapiens_hsa051430.46876083
93Phototransduction_Homo sapiens_hsa047440.45740165
94Leishmaniasis_Homo sapiens_hsa051400.44888566
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44675647
96Protein export_Homo sapiens_hsa030600.44012997
97Fructose and mannose metabolism_Homo sapiens_hsa000510.42126864
98Proteasome_Homo sapiens_hsa030500.41577384
99Parkinsons disease_Homo sapiens_hsa050120.40470238
100Linoleic acid metabolism_Homo sapiens_hsa005910.38792195
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35919534
102Fatty acid biosynthesis_Homo sapiens_hsa000610.29829416
103Galactose metabolism_Homo sapiens_hsa000520.28666758
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28624087
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26497422
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24121130
107Prion diseases_Homo sapiens_hsa050200.19095805
108Alzheimers disease_Homo sapiens_hsa050100.18678487
109Ribosome_Homo sapiens_hsa030100.15490196
110Pyrimidine metabolism_Homo sapiens_hsa002400.14380267
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.10836557
112Arachidonic acid metabolism_Homo sapiens_hsa005900.09687470
113Huntingtons disease_Homo sapiens_hsa050160.08894148
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.05003159
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1752980
116AMPK signaling pathway_Homo sapiens_hsa04152-0.1571889
117Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1522816
118Renin-angiotensin system_Homo sapiens_hsa04614-0.1427096
119Purine metabolism_Homo sapiens_hsa00230-0.1342176
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1335588
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.1189457
122Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0754963
123Other glycan degradation_Homo sapiens_hsa00511-0.0658442
124Regulation of autophagy_Homo sapiens_hsa04140-0.0572504
125Insulin resistance_Homo sapiens_hsa04931-0.0189860
126Ether lipid metabolism_Homo sapiens_hsa00565-0.0094453

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