

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 6.17256969 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.98500533 |
| 3 | locomotory exploration behavior (GO:0035641) | 5.86156258 |
| 4 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.77869158 |
| 5 | synaptic vesicle maturation (GO:0016188) | 5.65054336 |
| 6 | vocalization behavior (GO:0071625) | 5.57399234 |
| 7 | synaptic vesicle exocytosis (GO:0016079) | 5.47509949 |
| 8 | glutamate secretion (GO:0014047) | 5.39389575 |
| 9 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.36736616 |
| 10 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.29945906 |
| 11 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.28085314 |
| 12 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.25378238 |
| 13 | protein localization to synapse (GO:0035418) | 5.19330724 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.92599133 |
| 15 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.78799090 |
| 16 | neuron cell-cell adhesion (GO:0007158) | 4.77980808 |
| 17 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.73564920 |
| 18 | synaptic transmission, glutamatergic (GO:0035249) | 4.72685991 |
| 19 | neuronal action potential propagation (GO:0019227) | 4.66506529 |
| 20 | glutamate receptor signaling pathway (GO:0007215) | 4.61285400 |
| 21 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.58746811 |
| 22 | exploration behavior (GO:0035640) | 4.53025078 |
| 23 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.52055282 |
| 24 | regulation of synaptic vesicle transport (GO:1902803) | 4.44430078 |
| 25 | neuron-neuron synaptic transmission (GO:0007270) | 4.42743507 |
| 26 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.42706693 |
| 27 | regulation of synapse structural plasticity (GO:0051823) | 4.24158461 |
| 28 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.23481184 |
| 29 | positive regulation of synapse maturation (GO:0090129) | 4.16473671 |
| 30 | long-term memory (GO:0007616) | 4.16208648 |
| 31 | neurotransmitter secretion (GO:0007269) | 4.15983840 |
| 32 | L-amino acid import (GO:0043092) | 4.11528447 |
| 33 | positive regulation of membrane potential (GO:0045838) | 4.09301703 |
| 34 | regulation of dendritic spine morphogenesis (GO:0061001) | 4.06154368 |
| 35 | central nervous system projection neuron axonogenesis (GO:0021952) | 4.03391277 |
| 36 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.02745767 |
| 37 | regulation of synaptic plasticity (GO:0048167) | 3.98478449 |
| 38 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.96441380 |
| 39 | regulation of postsynaptic membrane potential (GO:0060078) | 3.94134523 |
| 40 | microtubule anchoring (GO:0034453) | 3.84619786 |
| 41 | gamma-aminobutyric acid transport (GO:0015812) | 3.83253665 |
| 42 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.80848913 |
| 43 | dendritic spine morphogenesis (GO:0060997) | 3.80451595 |
| 44 | postsynaptic membrane organization (GO:0001941) | 3.79760588 |
| 45 | long-term synaptic potentiation (GO:0060291) | 3.77750839 |
| 46 | regulation of synapse maturation (GO:0090128) | 3.76990713 |
| 47 | positive regulation of neurotransmitter transport (GO:0051590) | 3.67032009 |
| 48 | layer formation in cerebral cortex (GO:0021819) | 3.65078156 |
| 49 | regulation of pigment cell differentiation (GO:0050932) | 3.64776074 |
| 50 | short-term memory (GO:0007614) | 3.63367858 |
| 51 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.56279994 |
| 52 | cerebellar granule cell differentiation (GO:0021707) | 3.53422081 |
| 53 | regulation of neurotransmitter secretion (GO:0046928) | 3.52335850 |
| 54 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.50013060 |
| 55 | synaptic vesicle endocytosis (GO:0048488) | 3.49832135 |
| 56 | presynaptic membrane assembly (GO:0097105) | 3.48387405 |
| 57 | central nervous system neuron axonogenesis (GO:0021955) | 3.47916583 |
| 58 | transmission of nerve impulse (GO:0019226) | 3.47852696 |
| 59 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.46555810 |
| 60 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.44534971 |
| 61 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.41425515 |
| 62 | regulation of dendritic spine development (GO:0060998) | 3.39372913 |
| 63 | neuron recognition (GO:0008038) | 3.38583109 |
| 64 | activation of protein kinase A activity (GO:0034199) | 3.37264703 |
| 65 | regulation of glutamate secretion (GO:0014048) | 3.36116328 |
| 66 | negative regulation of dendrite development (GO:2000171) | 3.35952627 |
| 67 | behavioral defense response (GO:0002209) | 3.33247095 |
| 68 | behavioral fear response (GO:0001662) | 3.33247095 |
| 69 | positive regulation of developmental pigmentation (GO:0048087) | 3.32630686 |
| 70 | membrane depolarization (GO:0051899) | 3.31982031 |
| 71 | neurotransmitter transport (GO:0006836) | 3.29576817 |
| 72 | calcium ion-dependent exocytosis (GO:0017156) | 3.27997835 |
| 73 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.27615555 |
| 74 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.27379077 |
| 75 | response to histamine (GO:0034776) | 3.26732089 |
| 76 | neuromuscular process controlling balance (GO:0050885) | 3.26714913 |
| 77 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.25699846 |
| 78 | presynaptic membrane organization (GO:0097090) | 3.25253720 |
| 79 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.24550844 |
| 80 | regulation of neurotransmitter transport (GO:0051588) | 3.24264689 |
| 81 | cyclic nucleotide catabolic process (GO:0009214) | 3.24175125 |
| 82 | cellular potassium ion homeostasis (GO:0030007) | 3.21254789 |
| 83 | learning (GO:0007612) | 3.20111107 |
| 84 | startle response (GO:0001964) | 3.18814296 |
| 85 | dendritic spine organization (GO:0097061) | 3.17628771 |
| 86 | regulation of vesicle fusion (GO:0031338) | 3.17603605 |
| 87 | regulation of Rap GTPase activity (GO:0032317) | 3.17577626 |
| 88 | amino acid import (GO:0043090) | 3.17503472 |
| 89 | cAMP catabolic process (GO:0006198) | 3.16589577 |
| 90 | fear response (GO:0042596) | 3.14815586 |
| 91 | membrane depolarization during action potential (GO:0086010) | 3.13738221 |
| 92 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.12526603 |
| 93 | dopamine receptor signaling pathway (GO:0007212) | 3.12486060 |
| 94 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.12374408 |
| 95 | regulation of female receptivity (GO:0045924) | 3.10742381 |
| 96 | negative regulation of neurotransmitter secretion (GO:0046929) | 3.10155101 |
| 97 | regulation of neurotransmitter levels (GO:0001505) | 3.09734708 |
| 98 | proline transport (GO:0015824) | 3.08838320 |
| 99 | regulation of synaptic transmission (GO:0050804) | 3.08233071 |
| 100 | behavioral response to cocaine (GO:0048148) | 3.07881806 |
| 101 | positive regulation of dendritic spine development (GO:0060999) | 3.07834363 |
| 102 | neuronal ion channel clustering (GO:0045161) | 3.07075487 |
| 103 | auditory behavior (GO:0031223) | 3.05699473 |
| 104 | positive regulation of synaptic transmission (GO:0050806) | 3.04907541 |
| 105 | negative regulation of amino acid transport (GO:0051956) | 3.04764752 |
| 106 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.04667861 |
| 107 | synaptic vesicle transport (GO:0048489) | 3.04505966 |
| 108 | establishment of synaptic vesicle localization (GO:0097480) | 3.04505966 |
| 109 | microtubule nucleation (GO:0007020) | 3.04070508 |
| 110 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.03296982 |
| 111 | vesicle transport along microtubule (GO:0047496) | 3.02698145 |
| 112 | synaptic transmission (GO:0007268) | 3.00181336 |
| 113 | nerve growth factor signaling pathway (GO:0038180) | 2.99594679 |
| 114 | positive regulation of DNA-templated transcription, initiation (GO:2000144) | 2.99495456 |
| 115 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.98527069 |
| 116 | regulation of protein kinase A signaling (GO:0010738) | 2.96738841 |
| 117 | prepulse inhibition (GO:0060134) | 2.95005735 |
| 118 | microtubule polymerization or depolymerization (GO:0031109) | 2.94115717 |
| 119 | dendrite morphogenesis (GO:0048813) | 2.92200883 |
| 120 | membrane hyperpolarization (GO:0060081) | 2.90615788 |
| 121 | regulation of Rac protein signal transduction (GO:0035020) | 2.89959016 |
| 122 | polyol catabolic process (GO:0046174) | 2.89931332 |
| 123 | axonal fasciculation (GO:0007413) | 2.89747960 |
| 124 | synaptic transmission, dopaminergic (GO:0001963) | 2.89687067 |
| 125 | long term synaptic depression (GO:0060292) | 2.89491624 |
| 126 | intraspecies interaction between organisms (GO:0051703) | 2.86778400 |
| 127 | social behavior (GO:0035176) | 2.86778400 |
| 128 | response to auditory stimulus (GO:0010996) | 2.85540397 |
| 129 | mechanosensory behavior (GO:0007638) | 2.83155983 |
| 130 | atrial cardiac muscle cell action potential (GO:0086014) | 2.82601011 |
| 131 | sister chromatid segregation (GO:0000819) | 2.81679031 |
| 132 | protein K48-linked deubiquitination (GO:0071108) | 2.80143931 |
| 133 | C4-dicarboxylate transport (GO:0015740) | 2.80010709 |
| 134 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.75098729 |
| 135 | otic vesicle formation (GO:0030916) | 2.74146883 |
| 136 | organelle transport along microtubule (GO:0072384) | 2.74045401 |
| 137 | positive regulation of dendrite morphogenesis (GO:0050775) | 2.72974492 |
| 138 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.72810524 |
| 139 | negative regulation of neurotransmitter transport (GO:0051589) | 2.72142252 |
| 140 | glycosphingolipid biosynthetic process (GO:0006688) | 2.69989643 |
| 141 | sodium ion export (GO:0071436) | 2.69263421 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 7.05605863 |
| 2 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 3.56348036 |
| 3 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.50036221 |
| 4 | REST_21632747_ChIP-Seq_MESCs_Mouse | 3.21254193 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.13003946 |
| 6 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.99583563 |
| 7 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.97190584 |
| 8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.84284650 |
| 9 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.67875556 |
| 10 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.63252261 |
| 11 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.61079408 |
| 12 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.55921087 |
| 13 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.52688272 |
| 14 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.52688272 |
| 15 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.46094497 |
| 16 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.41920219 |
| 17 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.40755646 |
| 18 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.37185358 |
| 19 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.36032661 |
| 20 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.33399238 |
| 21 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.26277605 |
| 22 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.23079880 |
| 23 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.22547553 |
| 24 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.21407967 |
| 25 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.21401079 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.19044001 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.15571839 |
| 28 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.14886274 |
| 29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.11810063 |
| 30 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.11156184 |
| 31 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.09609631 |
| 32 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.94325195 |
| 33 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.92671883 |
| 34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.86547218 |
| 35 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.85135070 |
| 36 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.78758434 |
| 37 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.76137311 |
| 38 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.74922523 |
| 39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.74576956 |
| 40 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.68938160 |
| 41 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.67326694 |
| 42 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.63509194 |
| 43 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.62373072 |
| 44 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.59547149 |
| 45 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.58757885 |
| 46 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.54465928 |
| 47 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.51502519 |
| 48 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.44954212 |
| 49 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.43362211 |
| 50 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.43115890 |
| 51 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.41955681 |
| 52 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.41530738 |
| 53 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.41419451 |
| 54 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.41124026 |
| 55 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.40162956 |
| 56 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.37928238 |
| 57 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.35965063 |
| 58 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.34052956 |
| 59 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.33083913 |
| 60 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.32259293 |
| 61 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.31835135 |
| 62 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.31699521 |
| 63 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.31699521 |
| 64 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.31005673 |
| 65 | P300_19829295_ChIP-Seq_ESCs_Human | 1.30303070 |
| 66 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.29598726 |
| 67 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.28136304 |
| 68 | FUS_26573619_Chip-Seq_HEK293_Human | 1.27335264 |
| 69 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.25564277 |
| 70 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.24437096 |
| 71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.24131617 |
| 72 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.22945586 |
| 73 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.22525396 |
| 74 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22149646 |
| 75 | AR_25329375_ChIP-Seq_VCAP_Human | 1.21359484 |
| 76 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.20438430 |
| 77 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.19650991 |
| 78 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.19486577 |
| 79 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.18943139 |
| 80 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.18619286 |
| 81 | TCF4_23295773_ChIP-Seq_U87_Human | 1.18509054 |
| 82 | STAT3_23295773_ChIP-Seq_U87_Human | 1.17828147 |
| 83 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17584727 |
| 84 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.17526164 |
| 85 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.17112266 |
| 86 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.17042109 |
| 87 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.16287386 |
| 88 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.15988608 |
| 89 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.15370553 |
| 90 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.14698889 |
| 91 | AR_19668381_ChIP-Seq_PC3_Human | 1.14449017 |
| 92 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.14447979 |
| 93 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.13567416 |
| 94 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.12040004 |
| 95 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.11986335 |
| 96 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.11491739 |
| 97 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.10568773 |
| 98 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.10246801 |
| 99 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.09111878 |
| 100 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.08748063 |
| 101 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08748063 |
| 102 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.07103057 |
| 103 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.07075026 |
| 104 | VDR_22108803_ChIP-Seq_LS180_Human | 1.04514662 |
| 105 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.04483516 |
| 106 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.04421721 |
| 107 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.04378781 |
| 108 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.03523863 |
| 109 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.03375079 |
| 110 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.03226310 |
| 111 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.03187992 |
| 112 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.02880206 |
| 113 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.02763009 |
| 114 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.02128575 |
| 115 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.01766550 |
| 116 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.98986125 |
| 117 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.98442150 |
| 118 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.97380372 |
| 119 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.96952838 |
| 120 | JUN_21703547_ChIP-Seq_K562_Human | 0.96890532 |
| 121 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.96686881 |
| 122 | KDM2B_26808549_Chip-Seq_K562_Human | 0.95153877 |
| 123 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.94498934 |
| 124 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.94345623 |
| 125 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.92619937 |
| 126 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.91489129 |
| 127 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.89084169 |
| 128 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.87386864 |
| 129 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.85563969 |
| 130 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.84934100 |
| 131 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.84400394 |
| 132 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.84322045 |
| 133 | TP53_16413492_ChIP-PET_HCT116_Human | 0.83835434 |
| 134 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.83728341 |
| 135 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.83364235 |
| 136 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.82994864 |
| 137 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.82289361 |
| 138 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.81228135 |
| 139 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.81208806 |
| 140 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.79910361 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 7.20467210 |
| 2 | MP0003880_abnormal_central_pattern | 5.27015998 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.44119832 |
| 4 | MP0009745_abnormal_behavioral_response | 3.63164207 |
| 5 | MP0002822_catalepsy | 3.61089279 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.60716905 |
| 7 | MP0004270_analgesia | 3.39652599 |
| 8 | MP0002064_seizures | 3.24875382 |
| 9 | MP0009046_muscle_twitch | 3.07400703 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.91977435 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.87077057 |
| 12 | MP0003787_abnormal_imprinting | 2.71472339 |
| 13 | MP0002272_abnormal_nervous_system | 2.66734255 |
| 14 | MP0005423_abnormal_somatic_nervous | 2.59219299 |
| 15 | MP0001486_abnormal_startle_reflex | 2.56874118 |
| 16 | MP0010386_abnormal_urinary_bladder | 2.50827659 |
| 17 | MP0002736_abnormal_nociception_after | 2.29429416 |
| 18 | MP0002734_abnormal_mechanical_nocicepti | 2.27677745 |
| 19 | MP0001501_abnormal_sleep_pattern | 2.12843644 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.07366588 |
| 21 | MP0002735_abnormal_chemical_nociception | 2.06870939 |
| 22 | MP0008057_abnormal_DNA_replication | 1.95340352 |
| 23 | MP0002733_abnormal_thermal_nociception | 1.90293472 |
| 24 | MP0001970_abnormal_pain_threshold | 1.86984071 |
| 25 | MP0004811_abnormal_neuron_physiology | 1.86729699 |
| 26 | MP0002067_abnormal_sensory_capabilities | 1.85806906 |
| 27 | MP0008569_lethality_at_weaning | 1.80842889 |
| 28 | MP0002557_abnormal_social/conspecific_i | 1.80528530 |
| 29 | MP0005386_behavior/neurological_phenoty | 1.78446347 |
| 30 | MP0004924_abnormal_behavior | 1.78446347 |
| 31 | MP0003329_amyloid_beta_deposits | 1.78234401 |
| 32 | MP0003879_abnormal_hair_cell | 1.71783329 |
| 33 | MP0002184_abnormal_innervation | 1.61843641 |
| 34 | MP0000778_abnormal_nervous_system | 1.61655445 |
| 35 | MP0005410_abnormal_fertilization | 1.56373611 |
| 36 | MP0001529_abnormal_vocalization | 1.55866584 |
| 37 | MP0009780_abnormal_chondrocyte_physiolo | 1.55731020 |
| 38 | MP0003690_abnormal_glial_cell | 1.55443271 |
| 39 | MP0000569_abnormal_digit_pigmentation | 1.50186416 |
| 40 | MP0000955_abnormal_spinal_cord | 1.49159534 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.48075778 |
| 42 | MP0001188_hyperpigmentation | 1.41247283 |
| 43 | MP0001984_abnormal_olfaction | 1.41011785 |
| 44 | MP0002066_abnormal_motor_capabilities/c | 1.40526204 |
| 45 | MP0002882_abnormal_neuron_morphology | 1.35684497 |
| 46 | MP0003633_abnormal_nervous_system | 1.35619279 |
| 47 | MP0005646_abnormal_pituitary_gland | 1.34746983 |
| 48 | MP0008877_abnormal_DNA_methylation | 1.25590131 |
| 49 | MP0005187_abnormal_penis_morphology | 1.25108097 |
| 50 | MP0004858_abnormal_nervous_system | 1.24435477 |
| 51 | MP0002638_abnormal_pupillary_reflex | 1.23204852 |
| 52 | MP0002152_abnormal_brain_morphology | 1.18771124 |
| 53 | MP0001905_abnormal_dopamine_level | 1.17778975 |
| 54 | MP0003950_abnormal_plasma_membrane | 1.16771735 |
| 55 | MP0008961_abnormal_basal_metabolism | 1.16523117 |
| 56 | MP0003631_nervous_system_phenotype | 1.14717555 |
| 57 | MP0004885_abnormal_endolymph | 1.10473361 |
| 58 | MP0008874_decreased_physiological_sensi | 1.09097049 |
| 59 | MP0002163_abnormal_gland_morphology | 1.09013220 |
| 60 | MP0003890_abnormal_embryonic-extraembry | 0.99460263 |
| 61 | MP0006276_abnormal_autonomic_nervous | 0.98517247 |
| 62 | MP0005394_taste/olfaction_phenotype | 0.98171653 |
| 63 | MP0005499_abnormal_olfactory_system | 0.98171653 |
| 64 | MP0005645_abnormal_hypothalamus_physiol | 0.97953726 |
| 65 | MP0008872_abnormal_physiological_respon | 0.97931011 |
| 66 | MP0005174_abnormal_tail_pigmentation | 0.96589091 |
| 67 | MP0004142_abnormal_muscle_tone | 0.94643877 |
| 68 | MP0002229_neurodegeneration | 0.89813011 |
| 69 | MP0002069_abnormal_eating/drinking_beha | 0.89229307 |
| 70 | MP0000427_abnormal_hair_cycle | 0.88874211 |
| 71 | MP0001502_abnormal_circadian_rhythm | 0.88505098 |
| 72 | MP0003698_abnormal_male_reproductive | 0.86550278 |
| 73 | MP0004145_abnormal_muscle_electrophysio | 0.85397475 |
| 74 | MP0004742_abnormal_vestibular_system | 0.85112482 |
| 75 | MP0002009_preneoplasia | 0.83923689 |
| 76 | MP0004215_abnormal_myocardial_fiber | 0.81639501 |
| 77 | MP0005409_darkened_coat_color | 0.79098823 |
| 78 | MP0004085_abnormal_heartbeat | 0.79038166 |
| 79 | MP0003075_altered_response_to | 0.77434359 |
| 80 | MP0005551_abnormal_eye_electrophysiolog | 0.76482900 |
| 81 | MP0000647_abnormal_sebaceous_gland | 0.75328763 |
| 82 | MP0001986_abnormal_taste_sensitivity | 0.75244358 |
| 83 | MP0005623_abnormal_meninges_morphology | 0.74432925 |
| 84 | MP0009697_abnormal_copulation | 0.74005925 |
| 85 | MP0003632_abnormal_nervous_system | 0.73923311 |
| 86 | MP0005379_endocrine/exocrine_gland_phen | 0.73757610 |
| 87 | MP0000920_abnormal_myelination | 0.73511185 |
| 88 | MP0003121_genomic_imprinting | 0.71586579 |
| 89 | MP0001963_abnormal_hearing_physiology | 0.71219304 |
| 90 | MP0000604_amyloidosis | 0.70577022 |
| 91 | MP0003861_abnormal_nervous_system | 0.69943282 |
| 92 | MP0000372_irregular_coat_pigmentation | 0.69583028 |
| 93 | MP0010234_abnormal_vibrissa_follicle | 0.67998904 |
| 94 | MP0005220_abnormal_exocrine_pancreas | 0.66672244 |
| 95 | MP0002877_abnormal_melanocyte_morpholog | 0.66588203 |
| 96 | MP0004233_abnormal_muscle_weight | 0.66478117 |
| 97 | MP0004147_increased_porphyrin_level | 0.66444775 |
| 98 | MP0000751_myopathy | 0.66198560 |
| 99 | MP0000516_abnormal_urinary_system | 0.63543168 |
| 100 | MP0005367_renal/urinary_system_phenotyp | 0.63543168 |
| 101 | MP0005248_abnormal_Harderian_gland | 0.62774917 |
| 102 | MP0002752_abnormal_somatic_nervous | 0.62589902 |
| 103 | MP0002095_abnormal_skin_pigmentation | 0.62182776 |
| 104 | MP0002971_abnormal_brown_adipose | 0.62002849 |
| 105 | MP0002751_abnormal_autonomic_nervous | 0.61220794 |
| 106 | MP0005253_abnormal_eye_physiology | 0.60978627 |
| 107 | MP0010094_abnormal_chromosome_stability | 0.60306942 |
| 108 | MP0003385_abnormal_body_wall | 0.60284560 |
| 109 | MP0003123_paternal_imprinting | 0.59761501 |
| 110 | MP0000631_abnormal_neuroendocrine_gland | 0.59728994 |
| 111 | MP0010769_abnormal_survival | 0.59497191 |
| 112 | MP0001485_abnormal_pinna_reflex | 0.59015689 |
| 113 | MP0000013_abnormal_adipose_tissue | 0.58922196 |
| 114 | MP0001299_abnormal_eye_distance/ | 0.58630470 |
| 115 | MP0004484_altered_response_of | 0.58341763 |
| 116 | MP0001177_atelectasis | 0.58132966 |
| 117 | MP0000015_abnormal_ear_pigmentation | 0.57897885 |
| 118 | MP0002234_abnormal_pharynx_morphology | 0.57454231 |
| 119 | MP0010768_mortality/aging | 0.57024190 |
| 120 | MP0002082_postnatal_lethality | 0.56291151 |
| 121 | MP0010770_preweaning_lethality | 0.56291151 |
| 122 | MP0005535_abnormal_body_temperature | 0.55566058 |
| 123 | MP0003634_abnormal_glial_cell | 0.55038194 |
| 124 | MP0003956_abnormal_body_size | 0.54715590 |
| 125 | MP0003172_abnormal_lysosome_physiology | 0.53455655 |
| 126 | MP0004510_myositis | 0.49830878 |
| 127 | MP0002161_abnormal_fertility/fecundity | 0.49820278 |
| 128 | MP0003122_maternal_imprinting | 0.49766975 |
| 129 | MP0001943_abnormal_respiration | 0.49437652 |
| 130 | MP0001929_abnormal_gametogenesis | 0.47083808 |
| 131 | MP0005167_abnormal_blood-brain_barrier | 0.44243843 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.93622662 |
| 2 | Myokymia (HP:0002411) | 6.53554922 |
| 3 | Epileptic encephalopathy (HP:0200134) | 6.02895137 |
| 4 | Focal seizures (HP:0007359) | 5.58470033 |
| 5 | Visual hallucinations (HP:0002367) | 5.01013085 |
| 6 | Atonic seizures (HP:0010819) | 4.76896289 |
| 7 | Febrile seizures (HP:0002373) | 4.24234596 |
| 8 | Poor eye contact (HP:0000817) | 4.21960810 |
| 9 | Absence seizures (HP:0002121) | 3.93320938 |
| 10 | Progressive cerebellar ataxia (HP:0002073) | 3.82300657 |
| 11 | Dialeptic seizures (HP:0011146) | 3.67336666 |
| 12 | Impaired social interactions (HP:0000735) | 3.61875347 |
| 13 | Abnormal social behavior (HP:0012433) | 3.61875347 |
| 14 | Gaze-evoked nystagmus (HP:0000640) | 3.59643446 |
| 15 | Broad-based gait (HP:0002136) | 3.57793577 |
| 16 | Hyperventilation (HP:0002883) | 3.52111337 |
| 17 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.43369846 |
| 18 | Volvulus (HP:0002580) | 3.36324990 |
| 19 | Generalized tonic-clonic seizures (HP:0002069) | 3.35121653 |
| 20 | Urethral obstruction (HP:0000796) | 3.29410677 |
| 21 | Amblyopia (HP:0000646) | 3.29389377 |
| 22 | Abnormality of the lower motor neuron (HP:0002366) | 3.26127192 |
| 23 | Action tremor (HP:0002345) | 3.18244748 |
| 24 | Impaired smooth pursuit (HP:0007772) | 3.13421691 |
| 25 | Absent/shortened dynein arms (HP:0200106) | 3.05680819 |
| 26 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.05680819 |
| 27 | Dysmetria (HP:0001310) | 3.05024504 |
| 28 | Depression (HP:0000716) | 2.98673661 |
| 29 | Dysdiadochokinesis (HP:0002075) | 2.93471800 |
| 30 | Papilledema (HP:0001085) | 2.92925731 |
| 31 | Supranuclear gaze palsy (HP:0000605) | 2.88871617 |
| 32 | Truncal ataxia (HP:0002078) | 2.87667300 |
| 33 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.84980673 |
| 34 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.80457368 |
| 35 | Renal cortical cysts (HP:0000803) | 2.74956697 |
| 36 | Ankle clonus (HP:0011448) | 2.69565244 |
| 37 | Epileptiform EEG discharges (HP:0011182) | 2.68539698 |
| 38 | Anxiety (HP:0000739) | 2.66397688 |
| 39 | Amyotrophic lateral sclerosis (HP:0007354) | 2.65221388 |
| 40 | Dysmetric saccades (HP:0000641) | 2.63384867 |
| 41 | Urinary urgency (HP:0000012) | 2.58177336 |
| 42 | Drooling (HP:0002307) | 2.56739332 |
| 43 | Excessive salivation (HP:0003781) | 2.56739332 |
| 44 | Cerebral inclusion bodies (HP:0100314) | 2.56338079 |
| 45 | Annular pancreas (HP:0001734) | 2.54582352 |
| 46 | Stereotypic behavior (HP:0000733) | 2.52760464 |
| 47 | Postural instability (HP:0002172) | 2.50512813 |
| 48 | Abnormality of binocular vision (HP:0011514) | 2.50341302 |
| 49 | Diplopia (HP:0000651) | 2.50341302 |
| 50 | EEG with generalized epileptiform discharges (HP:0011198) | 2.49451130 |
| 51 | Disinhibition (HP:0000734) | 2.48718756 |
| 52 | Diminished motivation (HP:0000745) | 2.48281458 |
| 53 | Abnormality of salivation (HP:0100755) | 2.44215816 |
| 54 | Papillary thyroid carcinoma (HP:0002895) | 2.41990149 |
| 55 | Abnormal eating behavior (HP:0100738) | 2.39142617 |
| 56 | Impaired vibratory sensation (HP:0002495) | 2.38778512 |
| 57 | Pointed chin (HP:0000307) | 2.38575750 |
| 58 | Hypsarrhythmia (HP:0002521) | 2.37790483 |
| 59 | Scanning speech (HP:0002168) | 2.32954004 |
| 60 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.31768391 |
| 61 | Spastic gait (HP:0002064) | 2.29759220 |
| 62 | Progressive inability to walk (HP:0002505) | 2.25865799 |
| 63 | Bradykinesia (HP:0002067) | 2.25741929 |
| 64 | Absent speech (HP:0001344) | 2.23659630 |
| 65 | Delusions (HP:0000746) | 2.21679192 |
| 66 | Widely spaced teeth (HP:0000687) | 2.21297235 |
| 67 | Genetic anticipation (HP:0003743) | 2.19332793 |
| 68 | Hemiparesis (HP:0001269) | 2.17610790 |
| 69 | Protruding tongue (HP:0010808) | 2.16934873 |
| 70 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.16681935 |
| 71 | Short chin (HP:0000331) | 2.15929889 |
| 72 | Fetal akinesia sequence (HP:0001989) | 2.15210364 |
| 73 | Neurofibrillary tangles (HP:0002185) | 2.14780663 |
| 74 | Inappropriate behavior (HP:0000719) | 2.14433418 |
| 75 | Polyphagia (HP:0002591) | 2.10449929 |
| 76 | Inability to walk (HP:0002540) | 2.10040121 |
| 77 | Thickened helices (HP:0000391) | 2.08863341 |
| 78 | Insomnia (HP:0100785) | 2.06795499 |
| 79 | Ankyloglossia (HP:0010296) | 2.05729718 |
| 80 | Focal dystonia (HP:0004373) | 2.04703491 |
| 81 | Generalized hypopigmentation of hair (HP:0011358) | 2.01773705 |
| 82 | Clonus (HP:0002169) | 2.01112911 |
| 83 | Insidious onset (HP:0003587) | 2.00194327 |
| 84 | Termporal pattern (HP:0011008) | 2.00194327 |
| 85 | Mutism (HP:0002300) | 1.99032003 |
| 86 | Intention tremor (HP:0002080) | 1.98780346 |
| 87 | Resting tremor (HP:0002322) | 1.97882739 |
| 88 | Progressive external ophthalmoplegia (HP:0000590) | 1.96414227 |
| 89 | Athetosis (HP:0002305) | 1.95992149 |
| 90 | Medial flaring of the eyebrow (HP:0010747) | 1.94924766 |
| 91 | Generalized myoclonic seizures (HP:0002123) | 1.94566043 |
| 92 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.91758235 |
| 93 | Torticollis (HP:0000473) | 1.90172959 |
| 94 | Hemiplegia (HP:0002301) | 1.90025859 |
| 95 | Exotropia (HP:0000577) | 1.89922820 |
| 96 | Gait ataxia (HP:0002066) | 1.89273139 |
| 97 | Tented upper lip vermilion (HP:0010804) | 1.87840545 |
| 98 | Abnormal ciliary motility (HP:0012262) | 1.85588661 |
| 99 | Gastroesophageal reflux (HP:0002020) | 1.85177309 |
| 100 | Spastic paraplegia (HP:0001258) | 1.83645030 |
| 101 | Status epilepticus (HP:0002133) | 1.82827015 |
| 102 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.81455859 |
| 103 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.81455859 |
| 104 | Hepatoblastoma (HP:0002884) | 1.80879587 |
| 105 | Aqueductal stenosis (HP:0002410) | 1.80815766 |
| 106 | Cerebral hypomyelination (HP:0006808) | 1.80809303 |
| 107 | Abnormality of the corticospinal tract (HP:0002492) | 1.80780360 |
| 108 | Limb dystonia (HP:0002451) | 1.80675346 |
| 109 | Paraplegia (HP:0010550) | 1.80448197 |
| 110 | Cupped ear (HP:0000378) | 1.79987633 |
| 111 | Lower limb amyotrophy (HP:0007210) | 1.78711014 |
| 112 | Submucous cleft hard palate (HP:0000176) | 1.78208925 |
| 113 | Abnormality of the astrocytes (HP:0100707) | 1.77535397 |
| 114 | Astrocytoma (HP:0009592) | 1.77535397 |
| 115 | Hypoplasia of the corpus callosum (HP:0002079) | 1.77157399 |
| 116 | Horizontal nystagmus (HP:0000666) | 1.76492776 |
| 117 | Poor coordination (HP:0002370) | 1.76118817 |
| 118 | Incomplete penetrance (HP:0003829) | 1.75142586 |
| 119 | Fair hair (HP:0002286) | 1.74885479 |
| 120 | Intellectual disability, severe (HP:0010864) | 1.73664411 |
| 121 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.73389919 |
| 122 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.73389919 |
| 123 | Specific learning disability (HP:0001328) | 1.73041464 |
| 124 | Lower limb muscle weakness (HP:0007340) | 1.71365860 |
| 125 | Gait imbalance (HP:0002141) | 1.71122301 |
| 126 | Truncus arteriosus (HP:0001660) | 1.70548280 |
| 127 | Abnormality of saccadic eye movements (HP:0000570) | 1.70349820 |
| 128 | Megalencephaly (HP:0001355) | 1.69167881 |
| 129 | Abnormality of oral frenula (HP:0000190) | 1.68554325 |
| 130 | Congenital primary aphakia (HP:0007707) | 1.67194461 |
| 131 | Postural tremor (HP:0002174) | 1.67055439 |
| 132 | Blue irides (HP:0000635) | 1.66854633 |
| 133 | Apathy (HP:0000741) | 1.66351272 |
| 134 | Intellectual disability, moderate (HP:0002342) | 1.65626723 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NEK1 | 9.47910369 |
| 2 | EPHA4 | 5.47480852 |
| 3 | NTRK3 | 4.39713333 |
| 4 | MAP3K9 | 3.55933864 |
| 5 | DAPK2 | 3.46695857 |
| 6 | NEK2 | 3.22831436 |
| 7 | MAP3K4 | 2.92396019 |
| 8 | RIPK4 | 2.72606609 |
| 9 | MARK1 | 2.60567988 |
| 10 | MAP2K7 | 2.59223654 |
| 11 | FRK | 2.53239933 |
| 12 | NTRK2 | 2.38751044 |
| 13 | DAPK1 | 2.30917096 |
| 14 | CASK | 2.28850183 |
| 15 | KSR2 | 2.28324872 |
| 16 | MINK1 | 2.25049662 |
| 17 | MAP3K12 | 2.10285514 |
| 18 | PRKD3 | 2.07871160 |
| 19 | CAMKK1 | 1.93988675 |
| 20 | PAK6 | 1.93865817 |
| 21 | CDK19 | 1.91698041 |
| 22 | SIK2 | 1.86106117 |
| 23 | MAP2K4 | 1.77729245 |
| 24 | KSR1 | 1.76929727 |
| 25 | PLK2 | 1.69389142 |
| 26 | PLK4 | 1.69325193 |
| 27 | FES | 1.62234297 |
| 28 | AKT3 | 1.60267847 |
| 29 | MAP3K13 | 1.58077917 |
| 30 | CAMKK2 | 1.55100226 |
| 31 | WNK3 | 1.55056465 |
| 32 | PNCK | 1.53404060 |
| 33 | ARAF | 1.53300290 |
| 34 | PRPF4B | 1.48218871 |
| 35 | CDK5 | 1.46712086 |
| 36 | LMTK2 | 1.41625613 |
| 37 | BMPR2 | 1.32921620 |
| 38 | RAF1 | 1.28763358 |
| 39 | RIPK1 | 1.27202844 |
| 40 | TYRO3 | 1.26334777 |
| 41 | STK38 | 1.23138305 |
| 42 | PTK2B | 1.18471483 |
| 43 | GRK5 | 1.17851603 |
| 44 | NTRK1 | 1.16608537 |
| 45 | PRKCG | 1.12438810 |
| 46 | UHMK1 | 1.08672445 |
| 47 | MAP3K6 | 1.05386926 |
| 48 | INSRR | 1.00350015 |
| 49 | CDK18 | 0.98705310 |
| 50 | CDK15 | 0.97030783 |
| 51 | CDK11A | 0.92190217 |
| 52 | BRD4 | 0.89677023 |
| 53 | CDK14 | 0.88491389 |
| 54 | CAMK2A | 0.87165215 |
| 55 | STK11 | 0.86794589 |
| 56 | CCNB1 | 0.85512317 |
| 57 | TAOK1 | 0.83328802 |
| 58 | DAPK3 | 0.83151680 |
| 59 | CAMK2B | 0.82976615 |
| 60 | TNIK | 0.82400818 |
| 61 | TNK2 | 0.82200050 |
| 62 | MAPK13 | 0.81043674 |
| 63 | MAPKAPK5 | 0.80233780 |
| 64 | YES1 | 0.80158043 |
| 65 | CAMK1 | 0.79479593 |
| 66 | TYK2 | 0.79234215 |
| 67 | ERBB3 | 0.77373011 |
| 68 | MAP3K2 | 0.76343467 |
| 69 | ALK | 0.75988570 |
| 70 | LATS1 | 0.75630192 |
| 71 | CAMK1D | 0.73303688 |
| 72 | TRIM28 | 0.71608084 |
| 73 | PDK1 | 0.71456869 |
| 74 | PKN1 | 0.71027614 |
| 75 | CDK3 | 0.66867479 |
| 76 | GRK6 | 0.65622981 |
| 77 | FGFR2 | 0.65504183 |
| 78 | ACVR1B | 0.61818827 |
| 79 | LATS2 | 0.59529873 |
| 80 | TAF1 | 0.59199576 |
| 81 | DYRK1A | 0.59005678 |
| 82 | MAP4K2 | 0.58829227 |
| 83 | NUAK1 | 0.58798706 |
| 84 | RET | 0.57638782 |
| 85 | BRSK1 | 0.55249253 |
| 86 | PDPK1 | 0.55221727 |
| 87 | SGK223 | 0.54759605 |
| 88 | SGK494 | 0.54759605 |
| 89 | MAP3K1 | 0.54451572 |
| 90 | OXSR1 | 0.54218558 |
| 91 | NME1 | 0.53841648 |
| 92 | SGK1 | 0.51826325 |
| 93 | MARK2 | 0.46580077 |
| 94 | PRKACB | 0.46177252 |
| 95 | SCYL2 | 0.45932009 |
| 96 | PRKCH | 0.45476147 |
| 97 | PHKG1 | 0.44036208 |
| 98 | PHKG2 | 0.44036208 |
| 99 | FGR | 0.43733977 |
| 100 | MKNK2 | 0.43267333 |
| 101 | SGK2 | 0.41405300 |
| 102 | RPS6KA3 | 0.41065845 |
| 103 | PINK1 | 0.40540211 |
| 104 | MAPK10 | 0.40143374 |
| 105 | SGK3 | 0.39634217 |
| 106 | CSNK1D | 0.38938519 |
| 107 | STK38L | 0.37137131 |
| 108 | BMPR1B | 0.37051658 |
| 109 | FYN | 0.36836444 |
| 110 | STK3 | 0.36824427 |
| 111 | DMPK | 0.36030768 |
| 112 | BRAF | 0.36005286 |
| 113 | PRKD2 | 0.35703610 |
| 114 | MOS | 0.35110153 |
| 115 | MAPK4 | 0.35099821 |
| 116 | CAMK4 | 0.34676279 |
| 117 | NEK6 | 0.34588548 |
| 118 | EIF2AK3 | 0.34128560 |
| 119 | SIK3 | 0.33334494 |
| 120 | PLK3 | 0.33279572 |
| 121 | MUSK | 0.32069054 |
| 122 | CSNK1G2 | 0.32030474 |
| 123 | BUB1 | 0.31537724 |
| 124 | PRKCB | 0.31469267 |
| 125 | PDK3 | 0.31326221 |
| 126 | PDK4 | 0.31326221 |
| 127 | ROCK2 | 0.30171494 |
| 128 | MARK3 | 0.30122261 |
| 129 | ATM | 0.29696429 |
| 130 | BCR | 0.28015531 |
| 131 | PRKG1 | 0.27481937 |
| 132 | PRKCZ | 0.27435883 |
| 133 | ICK | 0.25432075 |
| 134 | CSNK1E | 0.23664553 |
| 135 | MAP2K6 | 0.22180692 |
| 136 | PAK3 | 0.21762951 |
| 137 | CAMK1G | 0.21561007 |
| 138 | MAP2K1 | 0.21253268 |
| 139 | GSK3B | 0.21082490 |
| 140 | MAPK12 | 0.19626668 |
| 141 | MAPK8 | 0.19482953 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.55691000 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.06525155 |
| 3 | Long-term potentiation_Homo sapiens_hsa04720 | 3.05499975 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.84033175 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.79488575 |
| 6 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.73744230 |
| 7 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.72716009 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.65011388 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.63522473 |
| 10 | GABAergic synapse_Homo sapiens_hsa04727 | 2.52706202 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.29274713 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.10763430 |
| 13 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.01817634 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.95862655 |
| 15 | Long-term depression_Homo sapiens_hsa04730 | 1.94238954 |
| 16 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.79935897 |
| 17 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.79823479 |
| 18 | Insulin secretion_Homo sapiens_hsa04911 | 1.79410312 |
| 19 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.75963816 |
| 20 | Taste transduction_Homo sapiens_hsa04742 | 1.70795698 |
| 21 | Renin secretion_Homo sapiens_hsa04924 | 1.68731442 |
| 22 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.67697231 |
| 23 | Cocaine addiction_Homo sapiens_hsa05030 | 1.59675400 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.57656231 |
| 25 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.53341470 |
| 26 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.48891030 |
| 27 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.42526793 |
| 28 | Gap junction_Homo sapiens_hsa04540 | 1.34788820 |
| 29 | Glioma_Homo sapiens_hsa05214 | 1.34713870 |
| 30 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.34384817 |
| 31 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.32086554 |
| 32 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.30710418 |
| 33 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.29314130 |
| 34 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.26130673 |
| 35 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.21753688 |
| 36 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.19900476 |
| 37 | Melanogenesis_Homo sapiens_hsa04916 | 1.09392222 |
| 38 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.05459753 |
| 39 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.04919461 |
| 40 | Alcoholism_Homo sapiens_hsa05034 | 1.00444242 |
| 41 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.99710801 |
| 42 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.99260221 |
| 43 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.98249706 |
| 44 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.92487403 |
| 45 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.90386511 |
| 46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.90232715 |
| 47 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.90145584 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.90019286 |
| 49 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.89594155 |
| 50 | Axon guidance_Homo sapiens_hsa04360 | 0.88934360 |
| 51 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.88379796 |
| 52 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.87842390 |
| 53 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.86714888 |
| 54 | Basal transcription factors_Homo sapiens_hsa03022 | 0.85834494 |
| 55 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.83690085 |
| 56 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.83360522 |
| 57 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.83128332 |
| 58 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.82072619 |
| 59 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.81728331 |
| 60 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.78867210 |
| 61 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.75987013 |
| 62 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.75207563 |
| 63 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.72454315 |
| 64 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.71542262 |
| 65 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.71531689 |
| 66 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.70835456 |
| 67 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.70137676 |
| 68 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.69201626 |
| 69 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.68895623 |
| 70 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.64726251 |
| 71 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.64317840 |
| 72 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.62945634 |
| 73 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.62074394 |
| 74 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.61032852 |
| 75 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.60756099 |
| 76 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.60284313 |
| 77 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.58791393 |
| 78 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.58459844 |
| 79 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.57182057 |
| 80 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.56908270 |
| 81 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.55276234 |
| 82 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.54933304 |
| 83 | Endocytosis_Homo sapiens_hsa04144 | 0.54286659 |
| 84 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.53585034 |
| 85 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.53580299 |
| 86 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.53440211 |
| 87 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.53054026 |
| 88 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.52222164 |
| 89 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.52095514 |
| 90 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.51710321 |
| 91 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.50762454 |
| 92 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.50593195 |
| 93 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.50385385 |
| 94 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.49049044 |
| 95 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.48413180 |
| 96 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.47377456 |
| 97 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.46410774 |
| 98 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.45942945 |
| 99 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.45131920 |
| 100 | Cell cycle_Homo sapiens_hsa04110 | 0.44412171 |
| 101 | Endometrial cancer_Homo sapiens_hsa05213 | 0.43821343 |
| 102 | Colorectal cancer_Homo sapiens_hsa05210 | 0.43718661 |
| 103 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.43399244 |
| 104 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.42309149 |
| 105 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.41725345 |
| 106 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.39468861 |
| 107 | ABC transporters_Homo sapiens_hsa02010 | 0.39071052 |
| 108 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.38793902 |
| 109 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.38495946 |
| 110 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.37883799 |
| 111 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.37866230 |
| 112 | Alzheimers disease_Homo sapiens_hsa05010 | 0.34109596 |
| 113 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.34085178 |
| 114 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.33785982 |
| 115 | Platelet activation_Homo sapiens_hsa04611 | 0.32744668 |
| 116 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.31016205 |
| 117 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.30031381 |
| 118 | Prion diseases_Homo sapiens_hsa05020 | 0.29748251 |
| 119 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.29141974 |
| 120 | Circadian rhythm_Homo sapiens_hsa04710 | 0.26396641 |
| 121 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.24192627 |

