CCT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.12168881
2formation of translation preinitiation complex (GO:0001731)4.84624298
3DNA strand elongation involved in DNA replication (GO:0006271)4.78120480
4nucleobase biosynthetic process (GO:0046112)4.75980641
5DNA replication initiation (GO:0006270)4.71072590
6DNA strand elongation (GO:0022616)4.52661399
7maturation of SSU-rRNA (GO:0030490)4.46489964
8purine nucleobase biosynthetic process (GO:0009113)4.40952243
9IMP biosynthetic process (GO:0006188)4.38498615
10regulation of translational fidelity (GO:0006450)4.28464914
11telomere maintenance via semi-conservative replication (GO:0032201)4.24489005
12folic acid-containing compound biosynthetic process (GO:0009396)4.22327827
13ribosomal small subunit assembly (GO:0000028)4.16661686
14DNA replication-dependent nucleosome assembly (GO:0006335)4.15318764
15DNA replication-dependent nucleosome organization (GO:0034723)4.15318764
16protein localization to kinetochore (GO:0034501)4.12694455
17sister chromatid segregation (GO:0000819)4.06067174
18mitotic nuclear envelope disassembly (GO:0007077)4.05820711
19nuclear pore organization (GO:0006999)4.05713188
20ribosome assembly (GO:0042255)3.98105863
21ribosome biogenesis (GO:0042254)3.93394198
22mitotic metaphase plate congression (GO:0007080)3.92686375
23DNA replication checkpoint (GO:0000076)3.88498450
24IMP metabolic process (GO:0046040)3.84685891
25telomere maintenance via recombination (GO:0000722)3.79095299
26membrane disassembly (GO:0030397)3.77878501
27nuclear envelope disassembly (GO:0051081)3.77878501
28ribosomal large subunit biogenesis (GO:0042273)3.74958145
29nuclear pore complex assembly (GO:0051292)3.74773131
30ribonucleoprotein complex biogenesis (GO:0022613)3.69380565
31mitotic recombination (GO:0006312)3.67044281
32mitotic sister chromatid cohesion (GO:0007064)3.62735059
33establishment of viral latency (GO:0019043)3.61324589
34chromatin remodeling at centromere (GO:0031055)3.55503716
35translational termination (GO:0006415)3.54334777
36viral transcription (GO:0019083)3.54125836
37CENP-A containing nucleosome assembly (GO:0034080)3.53175134
38telomere maintenance via telomere lengthening (GO:0010833)3.50367691
39spliceosomal snRNP assembly (GO:0000387)3.48565208
40protein localization to chromosome, centromeric region (GO:0071459)3.48465155
41translational initiation (GO:0006413)3.47310335
42protein complex localization (GO:0031503)3.44978160
43metaphase plate congression (GO:0051310)3.44120345
44non-recombinational repair (GO:0000726)3.43720552
45double-strand break repair via nonhomologous end joining (GO:0006303)3.43720552
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.40696248
47translational elongation (GO:0006414)3.38767171
48nucleobase-containing small molecule interconversion (GO:0015949)3.38706295
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36870518
50DNA replication-independent nucleosome organization (GO:0034724)3.36677788
51DNA replication-independent nucleosome assembly (GO:0006336)3.36677788
52DNA duplex unwinding (GO:0032508)3.35369844
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35320388
54rRNA processing (GO:0006364)3.34499188
55DNA geometric change (GO:0032392)3.33479169
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30381463
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30325007
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27683766
59establishment of integrated proviral latency (GO:0075713)3.27510259
60mitotic chromosome condensation (GO:0007076)3.24932238
61rRNA metabolic process (GO:0016072)3.23530162
62ribosomal small subunit biogenesis (GO:0042274)3.23043241
63COPI coating of Golgi vesicle (GO:0048205)3.21462240
64Golgi transport vesicle coating (GO:0048200)3.21462240
65proline biosynthetic process (GO:0006561)3.18823034
66nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17144715
67DNA deamination (GO:0045006)3.16433649
68somatic hypermutation of immunoglobulin genes (GO:0016446)3.13213652
69somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13213652
70regulation of spindle organization (GO:0090224)3.12249391
71L-serine metabolic process (GO:0006563)3.11917378
72mitotic sister chromatid segregation (GO:0000070)3.11120208
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11060572
74negative regulation of ligase activity (GO:0051352)3.11060572
75histone exchange (GO:0043486)3.10849646
76DNA ligation (GO:0006266)3.10549271
77G1/S transition of mitotic cell cycle (GO:0000082)3.08954686
78cell cycle G1/S phase transition (GO:0044843)3.08954686
79cellular protein complex localization (GO:0034629)3.08130128
80establishment of chromosome localization (GO:0051303)3.08106530
81folic acid metabolic process (GO:0046655)3.07230161
82regulation of mitotic spindle organization (GO:0060236)3.06899067
83regulation of mitochondrial translation (GO:0070129)3.06117474
84attachment of spindle microtubules to kinetochore (GO:0008608)3.05107614
85peptidyl-arginine omega-N-methylation (GO:0035247)3.04438586
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04102203
87transcription-coupled nucleotide-excision repair (GO:0006283)3.03758330
88negative regulation of chromosome segregation (GO:0051985)3.03428568
89spliceosomal tri-snRNP complex assembly (GO:0000244)3.02328819
90postreplication repair (GO:0006301)3.02200594
91tRNA aminoacylation for protein translation (GO:0006418)3.01940337
92kinetochore organization (GO:0051383)3.01900452
93negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01869959
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01869959
95negative regulation of sister chromatid segregation (GO:0033046)3.01869959
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.01869959
97DNA topological change (GO:0006265)3.01289861
98proteasome assembly (GO:0043248)2.99883743
99positive regulation of chromosome segregation (GO:0051984)2.98878038
100pseudouridine synthesis (GO:0001522)2.98572494
101mitotic spindle assembly checkpoint (GO:0007094)2.96520443
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96065875
103spindle assembly checkpoint (GO:0071173)2.95183575
104viral mRNA export from host cell nucleus (GO:0046784)2.93989503
105tRNA aminoacylation (GO:0043039)2.93880399
106amino acid activation (GO:0043038)2.93880399
107cullin deneddylation (GO:0010388)2.93383993
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92275940
109chromosome condensation (GO:0030261)2.92237207
110spindle checkpoint (GO:0031577)2.92062369
111nuclear envelope organization (GO:0006998)2.91839328
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91819070
113regulation of chromosome segregation (GO:0051983)2.90910572
114histone arginine methylation (GO:0034969)2.90683768
115negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90623154
116pore complex assembly (GO:0046931)2.90606598
117RNA splicing, via transesterification reactions (GO:0000375)2.90424913
118mRNA splicing, via spliceosome (GO:0000398)2.90374500
119RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.90374500
120mitotic spindle checkpoint (GO:0071174)2.90028009
121DNA conformation change (GO:0071103)2.88804775
122DNA synthesis involved in DNA repair (GO:0000731)2.85817644
123chromosome segregation (GO:0007059)2.84157475
124pteridine-containing compound biosynthetic process (GO:0042559)2.82687407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36067068
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57438438
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92257217
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.57128802
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48458846
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21255150
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01894681
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97736652
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94255393
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.91415627
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90519491
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.80008656
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.78277166
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77929071
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64196840
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54866414
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53787429
18XRN2_22483619_ChIP-Seq_HELA_Human2.46130476
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41462007
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32370252
21AR_21909140_ChIP-Seq_LNCAP_Human2.16935632
22VDR_23849224_ChIP-Seq_CD4+_Human2.14705723
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13671910
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08972222
25DCP1A_22483619_ChIP-Seq_HELA_Human2.01382442
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97246451
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97236571
28FOXP3_21729870_ChIP-Seq_TREG_Human1.91572189
29GABP_19822575_ChIP-Seq_HepG2_Human1.91026283
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.90362964
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.89810632
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88610922
33TTF2_22483619_ChIP-Seq_HELA_Human1.88020276
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87803247
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85684312
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79609542
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77098394
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75192573
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72822615
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68964024
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65997999
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62283046
43CIITA_25753668_ChIP-Seq_RAJI_Human1.60675484
44ELK1_19687146_ChIP-ChIP_HELA_Human1.59368080
45ZNF263_19887448_ChIP-Seq_K562_Human1.58937164
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.58226501
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57193532
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56198758
49* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52331893
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50050719
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49598235
52MYC_22102868_ChIP-Seq_BL_Human1.49546907
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47094454
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45782930
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43790607
56* KDM5A_27292631_Chip-Seq_BREAST_Human1.42737244
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42566009
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41689058
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37294086
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33681727
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32644949
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32556316
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.32044871
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30682212
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28956224
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26329095
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19324265
68* TFEB_21752829_ChIP-Seq_HELA_Human1.18264694
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15987491
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15534385
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15166739
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14503382
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13608893
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13375278
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12757207
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09636660
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.09363577
78* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09064519
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08641246
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06431946
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05684411
82* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04531523
83* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03777513
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.03307383
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00643569
86CHD1_26751641_Chip-Seq_LNCaP_Human1.00513347
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97289520
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95554209
89TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94691897
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94652309
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93861127
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92432469
93MYC_18940864_ChIP-ChIP_HL60_Human0.91702452
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.91230873
95* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89766605
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89060969
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88645604
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88562417
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88558925
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88480890
101NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87816692
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87400175
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87314215
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87011492
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86417467
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86406899
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.86299832
108* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84549992
109NOTCH1_21737748_ChIP-Seq_TLL_Human0.84549365
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84357739
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83398818
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82937394
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.81639986
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81314709
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80702160
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80484393
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80213724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.31507897
2MP0010094_abnormal_chromosome_stability4.65105869
3MP0004957_abnormal_blastocyst_morpholog4.64505436
4MP0003111_abnormal_nucleus_morphology4.41315602
5MP0003077_abnormal_cell_cycle4.07059411
6MP0008057_abnormal_DNA_replication3.60404208
7MP0008058_abnormal_DNA_repair3.36996895
8MP0003123_paternal_imprinting3.09286313
9MP0008007_abnormal_cellular_replicative2.99863628
10MP0008932_abnormal_embryonic_tissue2.86179669
11MP0001730_embryonic_growth_arrest2.74942873
12MP0010352_gastrointestinal_tract_polyps2.67904499
13MP0000350_abnormal_cell_proliferation2.39051851
14MP0008877_abnormal_DNA_methylation2.35719034
15MP0002877_abnormal_melanocyte_morpholog2.03730370
16MP0002396_abnormal_hematopoietic_system2.03399494
17MP0010307_abnormal_tumor_latency1.98333008
18MP0003806_abnormal_nucleotide_metabolis1.97137118
19MP0001697_abnormal_embryo_size1.92964701
20MP0003786_premature_aging1.92381295
21MP0005380_embryogenesis_phenotype1.90716649
22MP0001672_abnormal_embryogenesis/_devel1.90716649
23MP0010234_abnormal_vibrissa_follicle1.88788421
24MP0009697_abnormal_copulation1.80518612
25MP0002080_prenatal_lethality1.80197310
26MP0003984_embryonic_growth_retardation1.72824589
27MP0000537_abnormal_urethra_morphology1.72002386
28MP0002085_abnormal_embryonic_tissue1.70179788
29MP0002088_abnormal_embryonic_growth/wei1.68975477
30MP0002084_abnormal_developmental_patter1.67810202
31MP0004197_abnormal_fetal_growth/weight/1.65873788
32MP0010030_abnormal_orbit_morphology1.61264641
33MP0003121_genomic_imprinting1.55299522
34MP0001661_extended_life_span1.52217100
35MP0000490_abnormal_crypts_of1.51696108
36MP0002086_abnormal_extraembryonic_tissu1.50899681
37MP0003718_maternal_effect1.48182757
38MP0000313_abnormal_cell_death1.47648936
39MP0003567_abnormal_fetal_cardiomyocyte1.43804811
40MP0004808_abnormal_hematopoietic_stem1.37195618
41MP0001293_anophthalmia1.35472456
42MP0002019_abnormal_tumor_incidence1.34300971
43MP0002210_abnormal_sex_determination1.32048951
44MP0003890_abnormal_embryonic-extraembry1.29430476
45MP0005501_abnormal_skin_physiology1.27811536
46MP0003315_abnormal_perineum_morphology1.25537623
47MP0006054_spinal_hemorrhage1.24761903
48MP0001145_abnormal_male_reproductive1.19599199
49MP0002796_impaired_skin_barrier1.18789376
50MP0004133_heterotaxia1.18753566
51MP0004185_abnormal_adipocyte_glucose1.17149919
52MP0003119_abnormal_digestive_system1.16771232
53MP0000358_abnormal_cell_content/1.15916623
54MP0001346_abnormal_lacrimal_gland1.14330115
55MP0002653_abnormal_ependyma_morphology1.13744231
56MP0009053_abnormal_anal_canal1.07091922
57MP0005076_abnormal_cell_differentiation1.05448318
58MP0001929_abnormal_gametogenesis1.04589543
59MP0003705_abnormal_hypodermis_morpholog1.03678792
60MP0009333_abnormal_splenocyte_physiolog1.03007577
61MP0003221_abnormal_cardiomyocyte_apopto1.02145525
62MP0005408_hypopigmentation1.01222903
63MP0001545_abnormal_hematopoietic_system0.96948192
64MP0005397_hematopoietic_system_phenotyp0.96948192
65MP0000579_abnormal_nail_morphology0.96762418
66MP0005623_abnormal_meninges_morphology0.96759531
67MP0002160_abnormal_reproductive_system0.96703273
68MP0000653_abnormal_sex_gland0.96669513
69MP0002111_abnormal_tail_morphology0.94104126
70MP0009672_abnormal_birth_weight0.91990005
71MP0005384_cellular_phenotype0.86346870
72MP0005023_abnormal_wound_healing0.84376043
73MP0005451_abnormal_body_composition0.83852735
74MP0003186_abnormal_redox_activity0.83317388
75MP0000703_abnormal_thymus_morphology0.83293041
76MP0000762_abnormal_tongue_morphology0.82741958
77MP0003385_abnormal_body_wall0.80586355
78MP0008260_abnormal_autophagy0.79862421
79MP0000566_synostosis0.78819395
80MP0002060_abnormal_skin_morphology0.78605034
81MP0002938_white_spotting0.78397356
82MP0001915_intracranial_hemorrhage0.78036384
83MP0003937_abnormal_limbs/digits/tail_de0.78009199
84MP0003566_abnormal_cell_adhesion0.77796307
85MP0000678_abnormal_parathyroid_gland0.76846176
86MP0000627_abnormal_mammary_gland0.75867901
87MP0004272_abnormal_basement_membrane0.74681150
88MP0005621_abnormal_cell_physiology0.74475654
89MP0004233_abnormal_muscle_weight0.74395845
90MP0003763_abnormal_thymus_physiology0.74279331
91MP0001849_ear_inflammation0.73792064
92MP0000858_altered_metastatic_potential0.73788243
93MP0000428_abnormal_craniofacial_morphol0.73702688
94MP0002092_abnormal_eye_morphology0.72790485
95MP0002233_abnormal_nose_morphology0.71158180
96MP0003941_abnormal_skin_development0.69958468
97MP0002722_abnormal_immune_system0.69913250
98MP0006035_abnormal_mitochondrial_morpho0.69154578
99MP0009703_decreased_birth_body0.68712163
100MP0001881_abnormal_mammary_gland0.68348540
101MP0005389_reproductive_system_phenotype0.67264574
102MP0002398_abnormal_bone_marrow0.67226526
103MP0006292_abnormal_olfactory_placode0.67132854
104MP0001119_abnormal_female_reproductive0.66440501
105MP0002697_abnormal_eye_size0.66314093
106MP0001529_abnormal_vocalization0.65633438
107MP0002132_abnormal_respiratory_system0.65069371
108MP0001216_abnormal_epidermal_layer0.64769672
109MP0000477_abnormal_intestine_morphology0.63739837
110MP0000689_abnormal_spleen_morphology0.63016985
111MP0001286_abnormal_eye_development0.62949848
112MP0003935_abnormal_craniofacial_develop0.62018742
113MP0003115_abnormal_respiratory_system0.61770414
114MP0003943_abnormal_hepatobiliary_system0.61582134
115MP0000647_abnormal_sebaceous_gland0.61527136
116MP0005266_abnormal_metabolism0.60419464
117MP0000750_abnormal_muscle_regeneration0.59873827
118MP0001727_abnormal_embryo_implantation0.59208875
119MP0000733_abnormal_muscle_development0.58852175
120MP0003942_abnormal_urinary_system0.57734894
121MP0003698_abnormal_male_reproductive0.57646631
122MP0008770_decreased_survivor_rate0.56194789
123MP0002269_muscular_atrophy0.54954205
124MP0006036_abnormal_mitochondrial_physio0.54555430
125MP0002429_abnormal_blood_cell0.54538975
126MP0002161_abnormal_fertility/fecundity0.52932817
127MP0003861_abnormal_nervous_system0.52304542
128MP0004084_abnormal_cardiac_muscle0.52193231

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.89054944
2Abnormality of cells of the erythroid lineage (HP:0012130)4.09923918
3Abnormality of the anterior horn cell (HP:0006802)4.03988467
4Degeneration of anterior horn cells (HP:0002398)4.03988467
5Colon cancer (HP:0003003)4.01646126
6Reticulocytopenia (HP:0001896)3.99134001
7Selective tooth agenesis (HP:0001592)3.96877087
8Abnormal number of erythroid precursors (HP:0012131)3.84168007
9Breast hypoplasia (HP:0003187)3.74566550
10Ependymoma (HP:0002888)3.64566129
11Oral leukoplakia (HP:0002745)3.56242924
12Microvesicular hepatic steatosis (HP:0001414)3.50145459
13Medulloblastoma (HP:0002885)3.39505266
14Patellar aplasia (HP:0006443)3.12518262
15Cerebral hypomyelination (HP:0006808)3.11869867
16Carpal bone hypoplasia (HP:0001498)2.99902989
17Aplasia/Hypoplasia of the patella (HP:0006498)2.93662059
18Agnosia (HP:0010524)2.90590608
1911 pairs of ribs (HP:0000878)2.83262223
20Aplastic anemia (HP:0001915)2.82672843
21Rough bone trabeculation (HP:0100670)2.82191682
22Chromsome breakage (HP:0040012)2.77594371
23Neoplasm of the pancreas (HP:0002894)2.76321393
24Meckel diverticulum (HP:0002245)2.71141605
25Trismus (HP:0000211)2.69357303
26Progressive muscle weakness (HP:0003323)2.66596337
27Absent thumb (HP:0009777)2.63921452
28Macrocytic anemia (HP:0001972)2.63421636
29Rhabdomyosarcoma (HP:0002859)2.61738336
30Abnormality of the ileum (HP:0001549)2.59853152
31Abnormality of the preputium (HP:0100587)2.59283079
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59137499
33Abnormality of the labia minora (HP:0012880)2.58797238
34Multiple enchondromatosis (HP:0005701)2.57952159
35Abnormality of chromosome stability (HP:0003220)2.57298075
36Absent radius (HP:0003974)2.52138579
37Cortical dysplasia (HP:0002539)2.51503448
38Missing ribs (HP:0000921)2.50182000
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.48033854
40Impulsivity (HP:0100710)2.47684605
41Pallor (HP:0000980)2.46974819
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.41018605
43Progressive external ophthalmoplegia (HP:0000590)2.39813355
44Microretrognathia (HP:0000308)2.39145145
45Abnormal number of incisors (HP:0011064)2.38984760
46Premature graying of hair (HP:0002216)2.38613307
47Myelodysplasia (HP:0002863)2.37923257
48Abnormal gallbladder physiology (HP:0012438)2.36744534
49Cholecystitis (HP:0001082)2.36744534
50Abnormality of the astrocytes (HP:0100707)2.35383144
51Astrocytoma (HP:0009592)2.35383144
52Proximal placement of thumb (HP:0009623)2.35206123
53Basal cell carcinoma (HP:0002671)2.34869038
54Aplasia involving forearm bones (HP:0009822)2.34076553
55Absent forearm bone (HP:0003953)2.34076553
56Supernumerary spleens (HP:0009799)2.32895099
57Duodenal stenosis (HP:0100867)2.32562708
58Small intestinal stenosis (HP:0012848)2.32562708
59Abnormality of the umbilical cord (HP:0010881)2.31326445
60Deviation of the thumb (HP:0009603)2.31294109
61Abnormality of glycolysis (HP:0004366)2.30967296
62Increased serum pyruvate (HP:0003542)2.30967296
63Abnormal lung lobation (HP:0002101)2.29940790
64Atresia of the external auditory canal (HP:0000413)2.25697147
65Horseshoe kidney (HP:0000085)2.18729250
66Nephroblastoma (Wilms tumor) (HP:0002667)2.16330190
67Glioma (HP:0009733)2.16013748
68Sloping forehead (HP:0000340)2.14212886
69Angiofibromas (HP:0010615)2.10747636
70Adenoma sebaceum (HP:0009720)2.10747636
71Abnormality of methionine metabolism (HP:0010901)2.10540185
72Slender long bone (HP:0003100)2.09990887
73Glossoptosis (HP:0000162)2.09725554
74Bone marrow hypocellularity (HP:0005528)2.09630829
75Cellular immunodeficiency (HP:0005374)2.09561216
76Amaurosis fugax (HP:0100576)2.08918494
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08091071
78Tracheoesophageal fistula (HP:0002575)2.08084868
79Neoplasm of the colon (HP:0100273)2.05962144
80Ragged-red muscle fibers (HP:0003200)2.04625933
81Abnormality of the fetal cardiovascular system (HP:0010948)2.04369950
82Abnormal umbilical cord blood vessels (HP:0011403)2.04369950
83Single umbilical artery (HP:0001195)2.04369950
84Premature ovarian failure (HP:0008209)2.04342668
85Abnormality of the calcaneus (HP:0008364)2.03446957
86Choanal atresia (HP:0000453)2.03361451
87Abnormality of the carotid arteries (HP:0005344)2.03109856
88Overlapping toe (HP:0001845)2.02844589
89Increased nuchal translucency (HP:0010880)2.00206216
90Aplasia/hypoplasia of the humerus (HP:0006507)1.99535024
91Spastic diplegia (HP:0001264)1.99212932
92Squamous cell carcinoma (HP:0002860)1.99157575
93Insomnia (HP:0100785)1.98268934
94Abnormalities of placenta or umbilical cord (HP:0001194)1.97801641
95Embryonal renal neoplasm (HP:0011794)1.97673215
96Abnormality of the duodenum (HP:0002246)1.97488969
97Thrombocytosis (HP:0001894)1.97312678
98Cutaneous melanoma (HP:0012056)1.97307802
99Hyperacusis (HP:0010780)1.95844880
100Facial cleft (HP:0002006)1.94750783
101High anterior hairline (HP:0009890)1.94577666
102Abnormal trabecular bone morphology (HP:0100671)1.93801430
103Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93797443
104Pelvic girdle muscle weakness (HP:0003749)1.92138077
105Hypoplasia of the pons (HP:0012110)1.91553793
106Biliary tract neoplasm (HP:0100574)1.91153825
107Ovarian neoplasm (HP:0100615)1.90671772
108CNS hypomyelination (HP:0003429)1.90519185
109Spinal muscular atrophy (HP:0007269)1.90321519
110Neoplasm of striated muscle (HP:0009728)1.89627993
111Postnatal microcephaly (HP:0005484)1.89118180
112Microglossia (HP:0000171)1.88584922
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88010984
114Cleft eyelid (HP:0000625)1.87853245
115Cafe-au-lait spot (HP:0000957)1.85944136
116Neoplasm of the oral cavity (HP:0100649)1.85219818
117Freckling (HP:0001480)1.84115481
118Septate vagina (HP:0001153)1.83258187
119Broad distal phalanx of finger (HP:0009836)1.82729172
120Overriding aorta (HP:0002623)1.82250206
121Sparse eyelashes (HP:0000653)1.81581963
122Secondary amenorrhea (HP:0000869)1.80516174
123Triphalangeal thumb (HP:0001199)1.80048015
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.79833898
125Stenosis of the external auditory canal (HP:0000402)1.79749412
126Shoulder girdle muscle weakness (HP:0003547)1.79472876
127Type I transferrin isoform profile (HP:0003642)1.77814805
128Ectopic kidney (HP:0000086)1.76981259
129Increased serum lactate (HP:0002151)1.76976848
130Asymmetry of the thorax (HP:0001555)1.76904225
131Upper limb muscle weakness (HP:0003484)1.73661307
132Gout (HP:0001997)1.73441835
133Increased hepatocellular lipid droplets (HP:0006565)1.71806527
134Abnormality of cochlea (HP:0000375)1.70365411
135Reduced antithrombin III activity (HP:0001976)1.68068367
136Deep philtrum (HP:0002002)1.67164939
137Termporal pattern (HP:0011008)1.66284967
138Insidious onset (HP:0003587)1.66284967
139Duplication of thumb phalanx (HP:0009942)1.65326714
140Abnormality of reticulocytes (HP:0004312)1.65104314
141Entropion (HP:0000621)1.64970764
142Abnormal mitochondria in muscle tissue (HP:0008316)1.63280550
143Cerebral edema (HP:0002181)1.60175671
144Acute encephalopathy (HP:0006846)1.57119688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.46755791
2WEE14.33082498
3CDC74.12026331
4EIF2AK13.15880989
5TSSK62.98477646
6NEK12.63713295
7NEK22.58201690
8PASK2.38346805
9SRPK12.38057606
10VRK22.35091198
11SMG12.34512186
12TTK2.17428698
13ACVR1B2.11836582
14TESK22.04107591
15PLK11.91101066
16MST1R1.90913983
17NME21.89415075
18BRSK21.84674919
19STK161.80963711
20EIF2AK31.80346715
21MKNK11.79044707
22RPS6KB21.74220187
23PLK41.72120575
24SCYL21.70492236
25EEF2K1.68564776
26TGFBR11.66640863
27ATR1.65512421
28EPHA21.63758060
29RPS6KA41.61424906
30CDK71.60120095
31PLK31.58881111
32AURKB1.58590783
33DYRK31.57148432
34VRK11.56453708
35TESK11.44090780
36TLK11.42798355
37TAF11.39456823
38PAK41.38230984
39MAP3K81.36758719
40PKN21.35618888
41AURKA1.30717506
42CDK121.23294757
43CDK41.21301723
44ICK1.20893701
45CHEK21.20763615
46CHEK11.20191107
47IRAK31.17935437
48BRSK11.15410241
49PDK31.12721506
50PDK41.12721506
51STK101.06110382
52MAP3K101.03995147
53CCNB10.99289526
54PNCK0.94166893
55FLT30.93561652
56MKNK20.93013899
57LRRK20.91880539
58PIM20.84634861
59ERBB40.83115624
60ZAK0.81975576
61STK40.80952856
62CDK20.79844705
63ATM0.79521369
64LIMK10.79332413
65PAK10.76559485
66ALK0.75467153
67TRIM280.74859964
68CSNK2A20.73735250
69PIM10.72682526
70KDR0.67676021
71CSNK2A10.64786320
72BRD40.63586333
73CDK80.63301941
74CLK10.62145868
75PBK0.58454945
76CDK10.57032889
77DAPK10.55792325
78MAP3K110.55704628
79PRKCI0.54430414
80MAPKAPK30.53478043
81MAP2K30.53300239
82MELK0.52898876
83CSNK1G30.51454093
84BRAF0.51185692
85ILK0.49690008
86CDK60.49333075
87PDK20.48856534
88PTK20.47392033
89STK38L0.46354015
90LATS20.45557843
91PAK20.45519598
92MTOR0.44846827
93EIF2AK20.44577604
94RPS6KA50.44509616
95MAPKAPK50.44469951
96CDK11A0.44084609
97CDK180.43459066
98CSNK1A1L0.43202917
99CSNK1G10.43021111
100STK30.42802137
101CDK150.41750352
102TAOK20.41745410
103CSNK1E0.41617941
104PDGFRA0.41612401
105AKT20.41581861
106ARAF0.41126221
107FGFR10.40501637
108BCKDK0.40042078
109CDK90.38880367
110CDK140.37028112
111MAP3K90.36971578
112NME10.36863515
113TRIB30.35878894
114NTRK10.32159779
115MST40.31023140
116PRKDC0.30491048
117DYRK20.29563107
118BCR0.29521223
119MAP3K30.27502498
120TTN0.26646987
121ZAP700.25925304
122MAP4K10.23276002
123RAF10.18680171
124MET0.18147090
125RPS6KA10.15707684

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.90178907
2Mismatch repair_Homo sapiens_hsa034304.19040771
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.83133202
4Proteasome_Homo sapiens_hsa030503.77567991
5Spliceosome_Homo sapiens_hsa030403.36195655
6RNA transport_Homo sapiens_hsa030133.32448414
7Ribosome_Homo sapiens_hsa030103.26259072
8RNA polymerase_Homo sapiens_hsa030203.13397042
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.03751734
10Base excision repair_Homo sapiens_hsa034102.91073117
11One carbon pool by folate_Homo sapiens_hsa006702.89674453
12Nucleotide excision repair_Homo sapiens_hsa034202.88053259
13Homologous recombination_Homo sapiens_hsa034402.73376085
14Cell cycle_Homo sapiens_hsa041102.67164712
15Pyrimidine metabolism_Homo sapiens_hsa002402.42222955
16Fanconi anemia pathway_Homo sapiens_hsa034601.96049765
17Non-homologous end-joining_Homo sapiens_hsa034501.92215574
18RNA degradation_Homo sapiens_hsa030181.80347066
19Basal transcription factors_Homo sapiens_hsa030221.79304363
20mRNA surveillance pathway_Homo sapiens_hsa030151.75637945
21p53 signaling pathway_Homo sapiens_hsa041151.44498057
22Purine metabolism_Homo sapiens_hsa002301.27086919
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26589280
24Epstein-Barr virus infection_Homo sapiens_hsa051691.24178553
25Systemic lupus erythematosus_Homo sapiens_hsa053221.21893375
26Biosynthesis of amino acids_Homo sapiens_hsa012301.20397573
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.11317027
28Fatty acid elongation_Homo sapiens_hsa000621.07261746
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03968559
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03218844
31Selenocompound metabolism_Homo sapiens_hsa004501.03121248
32Viral carcinogenesis_Homo sapiens_hsa052031.00884013
33Oocyte meiosis_Homo sapiens_hsa041140.97363823
34Pentose phosphate pathway_Homo sapiens_hsa000300.97270415
35Steroid biosynthesis_Homo sapiens_hsa001000.96355381
36Antigen processing and presentation_Homo sapiens_hsa046120.96010405
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89665491
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89340550
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.86932292
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85917692
41Carbon metabolism_Homo sapiens_hsa012000.83869685
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83715042
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81848206
44Propanoate metabolism_Homo sapiens_hsa006400.78366972
45Herpes simplex infection_Homo sapiens_hsa051680.78269992
46Legionellosis_Homo sapiens_hsa051340.72574772
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72283422
48HTLV-I infection_Homo sapiens_hsa051660.72133746
49Vitamin B6 metabolism_Homo sapiens_hsa007500.71187961
50Folate biosynthesis_Homo sapiens_hsa007900.70918186
51Lysine degradation_Homo sapiens_hsa003100.70112696
52Thyroid cancer_Homo sapiens_hsa052160.70064612
53Sulfur relay system_Homo sapiens_hsa041220.68299485
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.64763355
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63882424
56Huntingtons disease_Homo sapiens_hsa050160.61018407
57Arginine biosynthesis_Homo sapiens_hsa002200.56902156
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56709267
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55152923
60Small cell lung cancer_Homo sapiens_hsa052220.53718773
61Glutathione metabolism_Homo sapiens_hsa004800.51469062
62MicroRNAs in cancer_Homo sapiens_hsa052060.49245532
63Fatty acid metabolism_Homo sapiens_hsa012120.47957814
64Hippo signaling pathway_Homo sapiens_hsa043900.47745608
65N-Glycan biosynthesis_Homo sapiens_hsa005100.46478204
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.46182167
67Alcoholism_Homo sapiens_hsa050340.45973708
68Protein export_Homo sapiens_hsa030600.44744403
69Fructose and mannose metabolism_Homo sapiens_hsa000510.44569901
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43371746
71Parkinsons disease_Homo sapiens_hsa050120.42021744
72Apoptosis_Homo sapiens_hsa042100.38783081
73TGF-beta signaling pathway_Homo sapiens_hsa043500.38469465
74Basal cell carcinoma_Homo sapiens_hsa052170.36384830
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36264584
76Colorectal cancer_Homo sapiens_hsa052100.36185611
77Bladder cancer_Homo sapiens_hsa052190.36004519
78Alzheimers disease_Homo sapiens_hsa050100.35309155
79Shigellosis_Homo sapiens_hsa051310.35181351
80Vibrio cholerae infection_Homo sapiens_hsa051100.32804864
81HIF-1 signaling pathway_Homo sapiens_hsa040660.31211526
82Phenylalanine metabolism_Homo sapiens_hsa003600.31147893
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30984473
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30374069
85Galactose metabolism_Homo sapiens_hsa000520.30139760
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28807251
87Pyruvate metabolism_Homo sapiens_hsa006200.28339398
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28301638
89Sulfur metabolism_Homo sapiens_hsa009200.28029285
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26785141
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25510342
92Chronic myeloid leukemia_Homo sapiens_hsa052200.25507936
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25395651
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24504661
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24438759
96Notch signaling pathway_Homo sapiens_hsa043300.24394915
97Hepatitis B_Homo sapiens_hsa051610.20342394
98Hedgehog signaling pathway_Homo sapiens_hsa043400.20133349
99Viral myocarditis_Homo sapiens_hsa054160.20085930
100Measles_Homo sapiens_hsa051620.20036054
101Tyrosine metabolism_Homo sapiens_hsa003500.19293839
102Metabolic pathways_Homo sapiens_hsa011000.19043989
103Pancreatic cancer_Homo sapiens_hsa052120.17562954
104Pathways in cancer_Homo sapiens_hsa052000.17246995
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17133333
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16665014
107Wnt signaling pathway_Homo sapiens_hsa043100.16576232
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16377938
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16228956
110Adherens junction_Homo sapiens_hsa045200.15267683
111Tight junction_Homo sapiens_hsa045300.14966524
112Non-small cell lung cancer_Homo sapiens_hsa052230.14801118
113mTOR signaling pathway_Homo sapiens_hsa041500.13755218
114Influenza A_Homo sapiens_hsa051640.13248781
115beta-Alanine metabolism_Homo sapiens_hsa004100.12639057
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.10816590
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10633021
118Renin-angiotensin system_Homo sapiens_hsa046140.09507938
119Arginine and proline metabolism_Homo sapiens_hsa003300.08855561
120Acute myeloid leukemia_Homo sapiens_hsa052210.08294424
121Oxidative phosphorylation_Homo sapiens_hsa001900.07963179
122Primary immunodeficiency_Homo sapiens_hsa053400.05895165
123Prostate cancer_Homo sapiens_hsa052150.05783513

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