CCT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.68152867
2DNA unwinding involved in DNA replication (GO:0006268)4.55117785
3maturation of SSU-rRNA (GO:0030490)4.47494892
4DNA strand elongation involved in DNA replication (GO:0006271)4.46665744
5nucleobase biosynthetic process (GO:0046112)4.37680750
6ribosomal small subunit assembly (GO:0000028)4.34058332
7nuclear pore organization (GO:0006999)4.28836401
8DNA replication initiation (GO:0006270)4.27537818
9DNA strand elongation (GO:0022616)4.22312967
10protein localization to kinetochore (GO:0034501)4.20091424
11purine nucleobase biosynthetic process (GO:0009113)4.19387267
12mitotic nuclear envelope disassembly (GO:0007077)4.11655699
13mitotic metaphase plate congression (GO:0007080)4.08445863
14ribosomal large subunit biogenesis (GO:0042273)4.06359535
15nuclear pore complex assembly (GO:0051292)4.05497054
16IMP biosynthetic process (GO:0006188)4.03683048
17DNA replication-dependent nucleosome assembly (GO:0006335)4.02507708
18DNA replication-dependent nucleosome organization (GO:0034723)4.02507708
19viral transcription (GO:0019083)4.00089867
20translational termination (GO:0006415)3.99834918
21telomere maintenance via semi-conservative replication (GO:0032201)3.98755068
22folic acid-containing compound biosynthetic process (GO:0009396)3.97236202
23ribosome assembly (GO:0042255)3.96631884
24membrane disassembly (GO:0030397)3.85046248
25nuclear envelope disassembly (GO:0051081)3.85046248
26establishment of viral latency (GO:0019043)3.78249722
27regulation of translational fidelity (GO:0006450)3.76199170
28mitotic sister chromatid cohesion (GO:0007064)3.75882183
29translational initiation (GO:0006413)3.74683347
30translational elongation (GO:0006414)3.72768411
31chromatin remodeling at centromere (GO:0031055)3.72576570
32DNA replication checkpoint (GO:0000076)3.70160247
33CENP-A containing nucleosome assembly (GO:0034080)3.68976095
34protein localization to chromosome, centromeric region (GO:0071459)3.68432957
35ribosome biogenesis (GO:0042254)3.68238875
36ribonucleoprotein complex biogenesis (GO:0022613)3.66700241
37metaphase plate congression (GO:0051310)3.62093086
38telomere maintenance via recombination (GO:0000722)3.61865232
39IMP metabolic process (GO:0046040)3.59407353
40mitotic recombination (GO:0006312)3.55028195
41regulation of spindle organization (GO:0090224)3.53912857
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51563577
43DNA replication-independent nucleosome organization (GO:0034724)3.47459280
44DNA replication-independent nucleosome assembly (GO:0006336)3.47459280
45kinetochore organization (GO:0051383)3.44543876
46ribosomal small subunit biogenesis (GO:0042274)3.42717614
47non-recombinational repair (GO:0000726)3.41921651
48double-strand break repair via nonhomologous end joining (GO:0006303)3.41921651
49telomere maintenance via telomere lengthening (GO:0010833)3.39776824
50tRNA aminoacylation for protein translation (GO:0006418)3.35698878
51mitotic chromosome condensation (GO:0007076)3.35170266
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.30454298
53tRNA aminoacylation (GO:0043039)3.28113792
54amino acid activation (GO:0043038)3.28113792
55protein complex localization (GO:0031503)3.26894528
56histone exchange (GO:0043486)3.25280958
57spliceosomal snRNP assembly (GO:0000387)3.24900105
58DNA ligation (GO:0006266)3.24806795
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24176882
60attachment of spindle microtubules to kinetochore (GO:0008608)3.22232036
61rRNA processing (GO:0006364)3.22201190
62heterochromatin organization (GO:0070828)3.21515489
63cotranslational protein targeting to membrane (GO:0006613)3.21170573
64establishment of chromosome localization (GO:0051303)3.21118318
65mitotic sister chromatid segregation (GO:0000070)3.20637665
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20423940
67protein targeting to ER (GO:0045047)3.20217885
68DNA duplex unwinding (GO:0032508)3.19750923
69cellular protein complex disassembly (GO:0043624)3.19423605
70DNA geometric change (GO:0032392)3.18355373
71regulation of mitochondrial translation (GO:0070129)3.17484970
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.16757305
73negative regulation of chromosome segregation (GO:0051985)3.15763335
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15113364
75negative regulation of sister chromatid segregation (GO:0033046)3.15113364
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.15113364
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15113364
78nucleobase-containing small molecule interconversion (GO:0015949)3.14488360
79viral life cycle (GO:0019058)3.13157331
80rRNA metabolic process (GO:0016072)3.12201273
81negative regulation of ligase activity (GO:0051352)3.11053568
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11053568
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10507981
84pore complex assembly (GO:0046931)3.10348348
85spindle assembly checkpoint (GO:0071173)3.09611895
86mitotic spindle assembly checkpoint (GO:0007094)3.09363391
87L-serine metabolic process (GO:0006563)3.08882138
88spindle checkpoint (GO:0031577)3.08711560
89synapsis (GO:0007129)3.07561882
90regulation of centrosome cycle (GO:0046605)3.04971889
91regulation of mitotic spindle organization (GO:0060236)3.04657546
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04417175
93establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03853841
94regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03782791
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03427277
96regulation of chromosome segregation (GO:0051983)3.03308365
97mitotic spindle checkpoint (GO:0071174)3.02506789
98DNA deamination (GO:0045006)3.02154319
99sister chromatid segregation (GO:0000819)3.01079023
100DNA synthesis involved in DNA repair (GO:0000731)3.00120091
101protein localization to endoplasmic reticulum (GO:0070972)3.00082935
102DNA topological change (GO:0006265)2.99564670
103kinetochore assembly (GO:0051382)2.99535007
104nuclear envelope organization (GO:0006998)2.99274571
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.99222794
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99222794
107regulation of helicase activity (GO:0051095)2.98178956
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97240557
109peptidyl-arginine omega-N-methylation (GO:0035247)2.96882559
110postreplication repair (GO:0006301)2.95957695
111regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95775067
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95694475
113protein complex disassembly (GO:0043241)2.94880456
114ATP-dependent chromatin remodeling (GO:0043044)2.94007855
115regulation of mitotic sister chromatid segregation (GO:0033047)2.93320443
116regulation of sister chromatid segregation (GO:0033045)2.93320443
117regulation of mitotic sister chromatid separation (GO:0010965)2.93320443
118regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92650169
119cellular protein complex localization (GO:0034629)2.92642260
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91845135
121regulation of sister chromatid cohesion (GO:0007063)2.91165354
122negative regulation of mRNA processing (GO:0050686)2.89815699
123chromatin assembly or disassembly (GO:0006333)2.89452651
124folic acid metabolic process (GO:0046655)2.89058915
125establishment of integrated proviral latency (GO:0075713)2.88218654
126proteasome assembly (GO:0043248)2.86552436
127positive regulation of chromosome segregation (GO:0051984)2.86545358
128nuclear-transcribed mRNA catabolic process (GO:0000956)2.86073011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.18850417
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.51073568
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.04611358
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68712642
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62220430
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17073497
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06097609
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90646629
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80206871
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77267047
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.72129928
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62685053
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.61370423
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.61326173
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53083221
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51661381
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51542012
18* XRN2_22483619_ChIP-Seq_HELA_Human2.41152246
19AR_21909140_ChIP-Seq_LNCAP_Human2.27556356
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26026066
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24309943
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.22897579
23* VDR_23849224_ChIP-Seq_CD4+_Human2.13468200
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03736177
25* DCP1A_22483619_ChIP-Seq_HELA_Human1.98283049
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95737430
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94979346
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94964632
29* E2F1_21310950_ChIP-Seq_MCF-7_Human1.91694005
30FOXP3_21729870_ChIP-Seq_TREG_Human1.90168683
31* TTF2_22483619_ChIP-Seq_HELA_Human1.85889026
32GABP_19822575_ChIP-Seq_HepG2_Human1.82451757
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81404125
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81071569
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80284539
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76868012
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72557689
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68325744
39ELK1_19687146_ChIP-ChIP_HELA_Human1.64023643
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60119206
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58854495
42MYC_22102868_ChIP-Seq_BL_Human1.58841849
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58404544
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57695078
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54499658
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52423800
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51613402
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51277725
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48203641
50ZNF263_19887448_ChIP-Seq_K562_Human1.47321067
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47208534
52CIITA_25753668_ChIP-Seq_RAJI_Human1.46562045
53KDM5A_27292631_Chip-Seq_BREAST_Human1.45776354
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42894133
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41894552
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40199649
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.32656618
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32241904
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31863940
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31195964
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31036069
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29981521
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29421605
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26534150
65TFEB_21752829_ChIP-Seq_HELA_Human1.24535966
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22139041
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20821728
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18384774
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17046574
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15382435
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14101855
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.13784860
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13225677
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13022634
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12195033
76SOX17_20123909_ChIP-Seq_XEN_Mouse1.11261443
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08809815
78* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06282020
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05812829
80* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05311460
81* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04069748
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03446224
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02571194
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02004260
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98389642
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97404324
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.97021617
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.96083860
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95652856
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95578335
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.94670431
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94176787
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.92814090
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.91384138
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91056924
96* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90450362
97MYC_18940864_ChIP-ChIP_HL60_Human0.90316088
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90228128
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90228128
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90228128
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89920674
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88541791
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88268275
104CHD1_26751641_Chip-Seq_LNCaP_Human0.87819634
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87014781
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85683681
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85182706
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84827814
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84666839
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84599220
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84586914
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83205955
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.81602251
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81048043
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80963619
116* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80888465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.03388765
2MP0004957_abnormal_blastocyst_morpholog4.46798761
3MP0010094_abnormal_chromosome_stability4.39218796
4MP0003111_abnormal_nucleus_morphology4.26337516
5MP0003077_abnormal_cell_cycle3.88177100
6MP0008057_abnormal_DNA_replication3.32224562
7MP0008058_abnormal_DNA_repair3.16870518
8MP0008007_abnormal_cellular_replicative2.99875182
9MP0010352_gastrointestinal_tract_polyps2.75751572
10MP0008932_abnormal_embryonic_tissue2.63640236
11MP0003123_paternal_imprinting2.50102192
12MP0001730_embryonic_growth_arrest2.49438250
13MP0000350_abnormal_cell_proliferation2.28604360
14MP0009697_abnormal_copulation2.17250672
15MP0002396_abnormal_hematopoietic_system2.04764645
16MP0010307_abnormal_tumor_latency1.91460636
17MP0003786_premature_aging1.88394695
18MP0001697_abnormal_embryo_size1.86973827
19MP0005380_embryogenesis_phenotype1.85069803
20MP0001672_abnormal_embryogenesis/_devel1.85069803
21MP0008877_abnormal_DNA_methylation1.83847437
22MP0002877_abnormal_melanocyte_morpholog1.78343758
23MP0010030_abnormal_orbit_morphology1.74238519
24MP0002080_prenatal_lethality1.70802652
25MP0003984_embryonic_growth_retardation1.69082092
26MP0000490_abnormal_crypts_of1.67121119
27MP0002088_abnormal_embryonic_growth/wei1.66162623
28MP0003567_abnormal_fetal_cardiomyocyte1.65104056
29MP0004197_abnormal_fetal_growth/weight/1.62655396
30MP0002084_abnormal_developmental_patter1.62039704
31MP0002085_abnormal_embryonic_tissue1.60808122
32MP0003806_abnormal_nucleotide_metabolis1.58317542
33MP0002086_abnormal_extraembryonic_tissu1.52694613
34MP0004808_abnormal_hematopoietic_stem1.52088588
35MP0006035_abnormal_mitochondrial_morpho1.50869150
36MP0003705_abnormal_hypodermis_morpholog1.44819105
37MP0000537_abnormal_urethra_morphology1.40778569
38MP0000313_abnormal_cell_death1.38638561
39MP0005076_abnormal_cell_differentiation1.36720943
40MP0002019_abnormal_tumor_incidence1.35206029
41MP0001293_anophthalmia1.32558890
42MP0001661_extended_life_span1.28210887
43MP0002210_abnormal_sex_determination1.26172472
44MP0009053_abnormal_anal_canal1.26136493
45MP0003718_maternal_effect1.25405084
46MP0006054_spinal_hemorrhage1.25098152
47MP0006292_abnormal_olfactory_placode1.24318784
48MP0003890_abnormal_embryonic-extraembry1.18948877
49MP0003121_genomic_imprinting1.16239104
50MP0003941_abnormal_skin_development1.15211716
51MP0001145_abnormal_male_reproductive1.14615502
52MP0003315_abnormal_perineum_morphology1.05980468
53MP0000358_abnormal_cell_content/1.02884718
54MP0005397_hematopoietic_system_phenotyp1.02381574
55MP0001545_abnormal_hematopoietic_system1.02381574
56MP0010234_abnormal_vibrissa_follicle1.01713508
57MP0003119_abnormal_digestive_system1.01625029
58MP0005023_abnormal_wound_healing1.00650916
59MP0001929_abnormal_gametogenesis1.00426288
60MP0009333_abnormal_splenocyte_physiolog0.99925938
61MP0001188_hyperpigmentation0.99736671
62MP0001529_abnormal_vocalization0.99125641
63MP0002796_impaired_skin_barrier0.98659710
64MP0005623_abnormal_meninges_morphology0.96291888
65MP0002938_white_spotting0.95387706
66MP0009672_abnormal_birth_weight0.95074085
67MP0003385_abnormal_body_wall0.95027597
68MP0006036_abnormal_mitochondrial_physio0.94369745
69MP0000703_abnormal_thymus_morphology0.94011802
70MP0009379_abnormal_foot_pigmentation0.93281939
71MP0003566_abnormal_cell_adhesion0.92325816
72MP0000653_abnormal_sex_gland0.92298175
73MP0001346_abnormal_lacrimal_gland0.92130821
74MP0004133_heterotaxia0.90328778
75MP0000858_altered_metastatic_potential0.89218266
76MP0003221_abnormal_cardiomyocyte_apopto0.89211972
77MP0004185_abnormal_adipocyte_glucose0.89006398
78MP0003763_abnormal_thymus_physiology0.88958154
79MP0002233_abnormal_nose_morphology0.88069835
80MP0002111_abnormal_tail_morphology0.87574156
81MP0002160_abnormal_reproductive_system0.86178553
82MP0001915_intracranial_hemorrhage0.84167013
83MP0000678_abnormal_parathyroid_gland0.83135097
84MP0000579_abnormal_nail_morphology0.82391874
85MP0002722_abnormal_immune_system0.81085781
86MP0005384_cellular_phenotype0.77856176
87MP0002398_abnormal_bone_marrow0.77485344
88MP0000428_abnormal_craniofacial_morphol0.76368308
89MP0003937_abnormal_limbs/digits/tail_de0.75581471
90MP0000762_abnormal_tongue_morphology0.74983407
91MP0003186_abnormal_redox_activity0.74703418
92MP0001727_abnormal_embryo_implantation0.74000620
93MP0000689_abnormal_spleen_morphology0.73886077
94MP0003861_abnormal_nervous_system0.73482852
95MP0008789_abnormal_olfactory_epithelium0.72162821
96MP0004782_abnormal_surfactant_physiolog0.71359595
97MP0008260_abnormal_autophagy0.71095697
98MP0005621_abnormal_cell_physiology0.70074839
99MP0000477_abnormal_intestine_morphology0.70069598
100MP0005389_reproductive_system_phenotype0.69759677
101MP0004272_abnormal_basement_membrane0.68895489
102MP0001119_abnormal_female_reproductive0.68492696
103MP0002653_abnormal_ependyma_morphology0.68492013
104MP0002092_abnormal_eye_morphology0.68463278
105MP0002161_abnormal_fertility/fecundity0.68250282
106MP0009703_decreased_birth_body0.67348545
107MP0003942_abnormal_urinary_system0.66864468
108MP0000733_abnormal_muscle_development0.66831896
109MP0000647_abnormal_sebaceous_gland0.65947286
110MP0001299_abnormal_eye_distance/0.65300108
111MP0001286_abnormal_eye_development0.65224634
112MP0001849_ear_inflammation0.64663906
113MP0005501_abnormal_skin_physiology0.62601957
114MP0003699_abnormal_female_reproductive0.61883194
115MP0002429_abnormal_blood_cell0.61524170
116MP0008995_early_reproductive_senescence0.61359322
117MP0002269_muscular_atrophy0.60833573
118MP0009278_abnormal_bone_marrow0.59101733
119MP0003115_abnormal_respiratory_system0.58606479
120MP0004084_abnormal_cardiac_muscle0.57550126
121MP0002282_abnormal_trachea_morphology0.56973528
122MP0001919_abnormal_reproductive_system0.56609992
123MP0004233_abnormal_muscle_weight0.56514013
124MP0002697_abnormal_eye_size0.55674008
125MP0002132_abnormal_respiratory_system0.55559958
126MP0001853_heart_inflammation0.54823863
127MP0000750_abnormal_muscle_regeneration0.54790218
128MP0000432_abnormal_head_morphology0.53763134
129MP0003448_altered_tumor_morphology0.53304706
130MP0002925_abnormal_cardiovascular_devel0.52668207
131MP0003698_abnormal_male_reproductive0.50964344
132MP0008770_decreased_survivor_rate0.48128701

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.46886944
2Colon cancer (HP:0003003)4.32075188
3Reticulocytopenia (HP:0001896)4.26367664
4Abnormality of cells of the erythroid lineage (HP:0012130)3.85681784
5Abnormality of the anterior horn cell (HP:0006802)3.82186820
6Degeneration of anterior horn cells (HP:0002398)3.82186820
7Ependymoma (HP:0002888)3.61833759
8Selective tooth agenesis (HP:0001592)3.58512465
9Abnormal number of erythroid precursors (HP:0012131)3.56550593
10Microvesicular hepatic steatosis (HP:0001414)3.55088651
11Breast hypoplasia (HP:0003187)3.52913325
12Abnormality of glycolysis (HP:0004366)3.49984491
13Oral leukoplakia (HP:0002745)3.48839736
14Medulloblastoma (HP:0002885)3.37092849
15Increased serum pyruvate (HP:0003542)3.35144191
16Carpal bone hypoplasia (HP:0001498)3.00943015
17Agnosia (HP:0010524)2.98800306
18Rough bone trabeculation (HP:0100670)2.92230675
19Patellar aplasia (HP:0006443)2.90191854
20Aplastic anemia (HP:0001915)2.82676274
21Trismus (HP:0000211)2.77405850
22Macrocytic anemia (HP:0001972)2.75524879
23Neoplasm of the pancreas (HP:0002894)2.74901428
24Chromsome breakage (HP:0040012)2.74842276
25Rhabdomyosarcoma (HP:0002859)2.73705291
26Aplasia/Hypoplasia of the patella (HP:0006498)2.72962619
27Supernumerary spleens (HP:0009799)2.69341720
28Absent thumb (HP:0009777)2.67695788
29Abnormality of chromosome stability (HP:0003220)2.67341872
30Nephroblastoma (Wilms tumor) (HP:0002667)2.62350932
31Pallor (HP:0000980)2.61381186
32Meckel diverticulum (HP:0002245)2.60905603
3311 pairs of ribs (HP:0000878)2.56984013
34Cortical dysplasia (HP:0002539)2.54921802
35Microretrognathia (HP:0000308)2.49719709
36Progressive muscle weakness (HP:0003323)2.49227648
37Basal cell carcinoma (HP:0002671)2.49209195
38Proximal placement of thumb (HP:0009623)2.47507223
39Progressive external ophthalmoplegia (HP:0000590)2.47131784
40Embryonal renal neoplasm (HP:0011794)2.46798015
41Abnormality of the ileum (HP:0001549)2.45088424
42Abnormality of the preputium (HP:0100587)2.44486981
43Myelodysplasia (HP:0002863)2.41664673
44Deviation of the thumb (HP:0009603)2.40933385
45Multiple enchondromatosis (HP:0005701)2.40444352
46Abnormality of the labia minora (HP:0012880)2.39976801
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35588431
48Absent radius (HP:0003974)2.34280444
49Small intestinal stenosis (HP:0012848)2.31780817
50Duodenal stenosis (HP:0100867)2.31780817
51Biliary tract neoplasm (HP:0100574)2.31191811
52Impulsivity (HP:0100710)2.30412191
53Atresia of the external auditory canal (HP:0000413)2.28354032
54Missing ribs (HP:0000921)2.26361679
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.26216185
56Abnormality of the astrocytes (HP:0100707)2.24965949
57Astrocytoma (HP:0009592)2.24965949
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.24260928
59Pelvic girdle muscle weakness (HP:0003749)2.22985437
60Abnormal lung lobation (HP:0002101)2.22880233
61Neoplasm of the colon (HP:0100273)2.22794021
62Premature graying of hair (HP:0002216)2.20135046
63Cerebral hypomyelination (HP:0006808)2.18223187
64Increased nuchal translucency (HP:0010880)2.16166759
65Abnormal trabecular bone morphology (HP:0100671)2.14956695
66Abnormality of methionine metabolism (HP:0010901)2.14587720
67Sloping forehead (HP:0000340)2.14526809
68Absent forearm bone (HP:0003953)2.14161414
69Aplasia involving forearm bones (HP:0009822)2.14161414
70Amaurosis fugax (HP:0100576)2.11059140
71Glioma (HP:0009733)2.10999266
72Thrombocytosis (HP:0001894)2.10142309
73Overlapping toe (HP:0001845)2.05610963
74Shoulder girdle muscle weakness (HP:0003547)2.04975740
75Glossoptosis (HP:0000162)2.04646262
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03822580
77Spastic diplegia (HP:0001264)2.02112905
78Horseshoe kidney (HP:0000085)2.01626117
79Increased hepatocellular lipid droplets (HP:0006565)2.00912639
80Abnormality of the calcaneus (HP:0008364)1.98860273
81Postnatal microcephaly (HP:0005484)1.96111229
82Abnormality of the duodenum (HP:0002246)1.95417211
83Slender long bone (HP:0003100)1.95325026
84Tracheoesophageal fistula (HP:0002575)1.94984859
85Neoplasm of striated muscle (HP:0009728)1.94031951
86Abnormality of the umbilical cord (HP:0010881)1.93640325
87Abnormality of the carotid arteries (HP:0005344)1.93488347
88Neoplasm of the oral cavity (HP:0100649)1.93453156
89Bone marrow hypocellularity (HP:0005528)1.93262816
90Angiofibromas (HP:0010615)1.93049135
91Adenoma sebaceum (HP:0009720)1.93049135
92Squamous cell carcinoma (HP:0002860)1.92042813
93Ovarian neoplasm (HP:0100615)1.91918012
94Type I transferrin isoform profile (HP:0003642)1.91426756
95Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91251137
96Abdominal situs inversus (HP:0003363)1.90377453
97Abnormality of abdominal situs (HP:0011620)1.90377453
98Choanal atresia (HP:0000453)1.90321129
99Increased serum lactate (HP:0002151)1.88806002
100Cellular immunodeficiency (HP:0005374)1.88789727
101High anterior hairline (HP:0009890)1.88228643
102Microglossia (HP:0000171)1.87570877
103Premature ovarian failure (HP:0008209)1.86234536
104Gout (HP:0001997)1.86000690
105Triphalangeal thumb (HP:0001199)1.83402272
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.83264410
107Volvulus (HP:0002580)1.83066034
108Abnormal number of incisors (HP:0011064)1.82932979
109Reduced antithrombin III activity (HP:0001976)1.82433778
110Cleft eyelid (HP:0000625)1.82218410
111Cholecystitis (HP:0001082)1.81303330
112Abnormal gallbladder physiology (HP:0012438)1.81303330
113Abnormality of cochlea (HP:0000375)1.80408566
114Neoplasm of the rectum (HP:0100743)1.80051552
115Insomnia (HP:0100785)1.79251916
116Ectopic kidney (HP:0000086)1.78809721
117Secondary amenorrhea (HP:0000869)1.78459645
118Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78234035
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78234035
120Cafe-au-lait spot (HP:0000957)1.78175592
121High pitched voice (HP:0001620)1.77860581
122Aplasia/hypoplasia of the humerus (HP:0006507)1.77704786
123Overriding aorta (HP:0002623)1.77529891
124Lipid accumulation in hepatocytes (HP:0006561)1.75503752
125Abnormality of the musculature of the pelvis (HP:0001469)1.75102415
126Abnormality of the hip-girdle musculature (HP:0001445)1.75102415
127Abnormal mitochondria in muscle tissue (HP:0008316)1.74583022
128Abnormality of the fetal cardiovascular system (HP:0010948)1.74103902
129Abnormal umbilical cord blood vessels (HP:0011403)1.74103902
130Single umbilical artery (HP:0001195)1.74103902
131Acute encephalopathy (HP:0006846)1.72292400
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72094096
133Abnormality of alanine metabolism (HP:0010916)1.72094096
134Hyperalaninemia (HP:0003348)1.72094096
135Ragged-red muscle fibers (HP:0003200)1.71204835
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70571106
137Abnormality of reticulocytes (HP:0004312)1.69749083
138Facial cleft (HP:0002006)1.68893909
139Intestinal polyp (HP:0005266)1.68391757
140Facial hemangioma (HP:0000329)1.67197391
141Duplication of thumb phalanx (HP:0009942)1.65688370
142Acute necrotizing encephalopathy (HP:0006965)1.64970774
143Cerebral edema (HP:0002181)1.64166263
144Abnormalities of placenta or umbilical cord (HP:0001194)1.63383844
145Short middle phalanx of the 5th finger (HP:0004220)1.62484783
146Megaloblastic anemia (HP:0001889)1.61056580
147Broad distal phalanx of finger (HP:0009836)1.59991074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44559399
2WEE14.28201591
3CDC73.81556548
4EIF2AK13.45372532
5NEK22.89758793
6NEK12.63146969
7TSSK62.42789928
8SRPK12.24017998
9TTK2.23615109
10VRK22.21706231
11NME22.13806602
12PASK2.13198137
13ACVR1B2.05165024
14BRSK22.01573557
15RPS6KB21.90917918
16PLK11.90316041
17PLK41.83312123
18TESK21.80901111
19RPS6KA41.80391521
20EIF2AK31.79698160
21MKNK11.76410875
22SCYL21.76277349
23TGFBR11.74235046
24EEF2K1.72238493
25SMG11.69006256
26TLK11.68748866
27EPHA21.67853307
28AURKB1.62002807
29CDK191.61693658
30DYRK31.59364292
31PLK31.56240416
32ATR1.55119962
33CDK71.53221464
34PKN21.44884178
35CDK121.41505669
36VRK11.38595989
37PAK41.37354409
38MAP3K81.35110307
39TRIM281.33232981
40STK161.31915146
41TAF11.31110164
42CHEK21.28967411
43CDK41.26829354
44AURKA1.21487348
45STK101.19996894
46TESK11.17081074
47MST41.15080737
48FLT31.14864484
49MST1R1.13593165
50PDK31.10311913
51PDK41.10311913
52CHEK11.09887973
53MKNK21.09343909
54BRSK11.04720693
55NME11.02789207
56ZAK0.89462293
57MAP3K100.88830530
58ALK0.88168146
59CDK60.86322135
60STK40.85332299
61ATM0.83816488
62BCR0.80425331
63MET0.79941806
64LRRK20.79811120
65ERBB40.79083778
66CCNB10.78839617
67PBK0.76768291
68CDK20.75065980
69PIM10.74066022
70ARAF0.72293566
71MAP2K30.70275594
72CLK10.68726528
73PAK10.67107266
74MAPKAPK30.66187326
75CSNK2A20.66123940
76KDR0.65463260
77MELK0.64751854
78CSNK1G30.64585324
79IRAK30.62357454
80TAOK20.60773121
81NEK90.60687258
82CSNK1G10.60120498
83PDK20.60091619
84CSNK2A10.59820484
85PIM20.59771747
86MAP3K110.59648349
87BRD40.59183224
88BCKDK0.55095960
89CDK11A0.55026111
90MAPKAPK50.53940487
91STK30.53819787
92CDK10.53266100
93CDK140.52110402
94CDK80.51185457
95CDK180.50960937
96CSNK1A1L0.50357763
97LIMK10.49692165
98DAPK10.49580641
99EIF2AK20.49363576
100RAF10.49275274
101CDK150.48817330
102MAP3K30.48431789
103RPS6KA50.47456826
104STK38L0.46153587
105PRKCI0.45729238
106MAP4K10.45456995
107ICK0.42331724
108PAK20.42230152
109MTOR0.40374380
110PNCK0.39254201
111CDK90.39002239
112CSNK1G20.38192471
113MAP3K90.37728490
114TRIB30.36205803
115FGFR10.35218244
116AKT20.34380338
117ZAP700.33582657
118ILK0.33053708
119PRKDC0.32862933
120CSNK1E0.30759759
121BRAF0.30485206
122LATS10.30066126
123LATS20.29310156
124MAP3K50.23134300
125JAK30.21643932
126MARK30.21419489
127DYRK20.21120362
128TTN0.20482694
129BTK0.18019710

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.71522626
2Mismatch repair_Homo sapiens_hsa034304.14696046
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69568998
4Ribosome_Homo sapiens_hsa030103.55295279
5RNA transport_Homo sapiens_hsa030133.34613218
6Spliceosome_Homo sapiens_hsa030403.34074564
7Proteasome_Homo sapiens_hsa030503.26302442
8Base excision repair_Homo sapiens_hsa034102.87173547
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.85228767
10One carbon pool by folate_Homo sapiens_hsa006702.83441245
11Homologous recombination_Homo sapiens_hsa034402.80301071
12Nucleotide excision repair_Homo sapiens_hsa034202.80105074
13RNA polymerase_Homo sapiens_hsa030202.79731589
14Cell cycle_Homo sapiens_hsa041102.73075090
15Pyrimidine metabolism_Homo sapiens_hsa002402.27611549
16Fanconi anemia pathway_Homo sapiens_hsa034602.03040806
17Non-homologous end-joining_Homo sapiens_hsa034501.96644538
18mRNA surveillance pathway_Homo sapiens_hsa030151.81909298
19RNA degradation_Homo sapiens_hsa030181.81353205
20Basal transcription factors_Homo sapiens_hsa030221.79389357
21p53 signaling pathway_Homo sapiens_hsa041151.67049323
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36094058
23Epstein-Barr virus infection_Homo sapiens_hsa051691.27264966
24Systemic lupus erythematosus_Homo sapiens_hsa053221.25879208
25Fatty acid elongation_Homo sapiens_hsa000621.18149765
26Purine metabolism_Homo sapiens_hsa002301.17952215
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16762956
28Steroid biosynthesis_Homo sapiens_hsa001001.09913552
29Selenocompound metabolism_Homo sapiens_hsa004501.09025990
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.08627927
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07931816
32Antigen processing and presentation_Homo sapiens_hsa046121.07354801
33Parkinsons disease_Homo sapiens_hsa050121.06476048
34Biosynthesis of amino acids_Homo sapiens_hsa012301.06281465
35Viral carcinogenesis_Homo sapiens_hsa052031.04390763
36Oocyte meiosis_Homo sapiens_hsa041141.03150225
37Propanoate metabolism_Homo sapiens_hsa006400.96786664
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.96645864
39Herpes simplex infection_Homo sapiens_hsa051680.92249974
40Pentose phosphate pathway_Homo sapiens_hsa000300.91544809
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90845157
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89941716
43Folate biosynthesis_Homo sapiens_hsa007900.86274429
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84735565
45Oxidative phosphorylation_Homo sapiens_hsa001900.83538008
46HTLV-I infection_Homo sapiens_hsa051660.82134356
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80076039
48Legionellosis_Homo sapiens_hsa051340.79524963
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75730762
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.72675366
51Carbon metabolism_Homo sapiens_hsa012000.72205182
52Thyroid cancer_Homo sapiens_hsa052160.71915974
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70195186
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64539423
55Sulfur relay system_Homo sapiens_hsa041220.64350012
56Small cell lung cancer_Homo sapiens_hsa052220.61939845
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61842713
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60777510
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60694066
60MicroRNAs in cancer_Homo sapiens_hsa052060.60511033
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56991448
62Vitamin B6 metabolism_Homo sapiens_hsa007500.55953989
63Hippo signaling pathway_Homo sapiens_hsa043900.54673636
64Protein export_Homo sapiens_hsa030600.52370453
65TGF-beta signaling pathway_Homo sapiens_hsa043500.52358316
66Glutathione metabolism_Homo sapiens_hsa004800.50019567
67Arginine and proline metabolism_Homo sapiens_hsa003300.48982188
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47437868
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46946422
70Lysine degradation_Homo sapiens_hsa003100.46587413
71Fatty acid metabolism_Homo sapiens_hsa012120.45179023
72Apoptosis_Homo sapiens_hsa042100.44540366
73Shigellosis_Homo sapiens_hsa051310.43964779
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43682246
75Alzheimers disease_Homo sapiens_hsa050100.43416634
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.43230239
77Colorectal cancer_Homo sapiens_hsa052100.42922465
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40525435
79Alcoholism_Homo sapiens_hsa050340.40235783
80Fructose and mannose metabolism_Homo sapiens_hsa000510.40011506
81N-Glycan biosynthesis_Homo sapiens_hsa005100.39920908
82Basal cell carcinoma_Homo sapiens_hsa052170.39154454
83Bladder cancer_Homo sapiens_hsa052190.37649449
84Arginine biosynthesis_Homo sapiens_hsa002200.36846557
85HIF-1 signaling pathway_Homo sapiens_hsa040660.36094517
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34823785
87Chronic myeloid leukemia_Homo sapiens_hsa052200.32241257
88Hepatitis B_Homo sapiens_hsa051610.32211526
89Measles_Homo sapiens_hsa051620.31187581
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30628549
91Adherens junction_Homo sapiens_hsa045200.30169933
92Galactose metabolism_Homo sapiens_hsa000520.28769969
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28630971
94Viral myocarditis_Homo sapiens_hsa054160.28320976
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27706970
96Huntingtons disease_Homo sapiens_hsa050160.26596725
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24107650
98Notch signaling pathway_Homo sapiens_hsa043300.23693126
99Pathways in cancer_Homo sapiens_hsa052000.23117940
100Influenza A_Homo sapiens_hsa051640.22440856
101Primary immunodeficiency_Homo sapiens_hsa053400.22252432
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20501393
103Renin-angiotensin system_Homo sapiens_hsa046140.20467121
104Hedgehog signaling pathway_Homo sapiens_hsa043400.19493457
105mTOR signaling pathway_Homo sapiens_hsa041500.19262377
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18497652
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.16624492
108Tight junction_Homo sapiens_hsa045300.16059626
109Acute myeloid leukemia_Homo sapiens_hsa052210.15879874
110Vibrio cholerae infection_Homo sapiens_hsa051100.15716917
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14939192
112Pyruvate metabolism_Homo sapiens_hsa006200.14858725
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14319413
114Proteoglycans in cancer_Homo sapiens_hsa052050.12630820
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12596729
116Metabolic pathways_Homo sapiens_hsa011000.11834825
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11346495
118Prostate cancer_Homo sapiens_hsa052150.09953743
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.07907314
120Hematopoietic cell lineage_Homo sapiens_hsa046400.07854896
121Pancreatic cancer_Homo sapiens_hsa052120.06605040
122Wnt signaling pathway_Homo sapiens_hsa043100.05512966

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