CCT4P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.96482608
2retinal cone cell development (GO:0046549)5.75489596
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.52426388
4DNA integration (GO:0015074)5.45551397
5peptidyl-histidine modification (GO:0018202)5.24286197
6replication fork processing (GO:0031297)4.88954385
7fucose catabolic process (GO:0019317)4.85689757
8L-fucose metabolic process (GO:0042354)4.85689757
9L-fucose catabolic process (GO:0042355)4.85689757
10C4-dicarboxylate transport (GO:0015740)4.36434577
11epithelial cilium movement (GO:0003351)4.17012341
12limb bud formation (GO:0060174)3.82665090
13regulation of non-canonical Wnt signaling pathway (GO:2000050)3.82439277
14pyrimidine nucleobase catabolic process (GO:0006208)3.80364843
15kinetochore organization (GO:0051383)3.78699169
16nonmotile primary cilium assembly (GO:0035058)3.75254938
17presynaptic membrane assembly (GO:0097105)3.68791896
18regulation of development, heterochronic (GO:0040034)3.63294010
19maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.59771938
20response to pheromone (GO:0019236)3.56692412
21intraciliary transport (GO:0042073)3.51760958
22acrosome assembly (GO:0001675)3.39773119
23S-adenosylmethionine metabolic process (GO:0046500)3.36641248
24viral mRNA export from host cell nucleus (GO:0046784)3.34678771
25cerebral cortex radially oriented cell migration (GO:0021799)3.30735048
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.30054023
27regulation of translation, ncRNA-mediated (GO:0045974)3.30054023
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30054023
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.28966211
30retinal ganglion cell axon guidance (GO:0031290)3.28590515
31appendage development (GO:0048736)3.26949154
32limb development (GO:0060173)3.26949154
33cilium morphogenesis (GO:0060271)3.24196074
34cell proliferation in forebrain (GO:0021846)3.14223385
35meiotic chromosome segregation (GO:0045132)3.12417026
36regulation of timing of cell differentiation (GO:0048505)3.12105647
37homocysteine metabolic process (GO:0050667)3.10043694
38negative regulation of DNA recombination (GO:0045910)3.06658172
39neural tube formation (GO:0001841)3.02572080
40cilium movement (GO:0003341)2.99929402
41nucleobase catabolic process (GO:0046113)2.99151491
42kinetochore assembly (GO:0051382)2.98267891
43regulation of hexokinase activity (GO:1903299)2.91877855
44regulation of glucokinase activity (GO:0033131)2.91877855
45olfactory bulb development (GO:0021772)2.90812758
46centriole replication (GO:0007099)2.89553614
47positive regulation of neuroblast proliferation (GO:0002052)2.89023930
48presynaptic membrane organization (GO:0097090)2.88360330
49double-strand break repair via homologous recombination (GO:0000724)2.86551990
50photoreceptor cell development (GO:0042461)2.86509977
51recombinational repair (GO:0000725)2.85256219
52otic vesicle formation (GO:0030916)2.84500640
53positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.84169461
54dendritic spine morphogenesis (GO:0060997)2.79569843
55regulation of hippo signaling (GO:0035330)2.79519244
56eye photoreceptor cell development (GO:0042462)2.79501858
57forebrain neuron differentiation (GO:0021879)2.79368066
58glycosphingolipid biosynthetic process (GO:0006688)2.75314351
59axonal fasciculation (GO:0007413)2.74189231
60inner ear receptor stereocilium organization (GO:0060122)2.73607166
61fucosylation (GO:0036065)2.73268231
62cilium organization (GO:0044782)2.73009875
63cilium assembly (GO:0042384)2.72369748
64detection of light stimulus involved in sensory perception (GO:0050962)2.72328089
65detection of light stimulus involved in visual perception (GO:0050908)2.72328089
66pyrimidine dimer repair (GO:0006290)2.70687801
67smoothened signaling pathway (GO:0007224)2.69903326
68ventricular system development (GO:0021591)2.68812284
69negative regulation of DNA-dependent DNA replication (GO:2000104)2.67932250
70protein-cofactor linkage (GO:0018065)2.67701569
71kidney morphogenesis (GO:0060993)2.66515488
72somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66124849
73somatic hypermutation of immunoglobulin genes (GO:0016446)2.66124849
74regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.63871639
75intra-S DNA damage checkpoint (GO:0031573)2.60574472
76determination of left/right symmetry (GO:0007368)2.59876974
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.58784451
78positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58158661
79serine family amino acid catabolic process (GO:0009071)2.58146839
80somite development (GO:0061053)2.57624067
81DNA catabolic process, exonucleolytic (GO:0000738)2.57469813
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56849458
83vocalization behavior (GO:0071625)2.53612806
84protein K6-linked ubiquitination (GO:0085020)2.52607132
85embryonic digestive tract morphogenesis (GO:0048557)2.51704317
86lysine metabolic process (GO:0006553)2.49970405
87lysine catabolic process (GO:0006554)2.49970405
88head development (GO:0060322)2.49799377
89platelet dense granule organization (GO:0060155)2.48594467
90reciprocal DNA recombination (GO:0035825)2.47688878
91reciprocal meiotic recombination (GO:0007131)2.47688878
92microtubule polymerization or depolymerization (GO:0031109)2.47592926
93apical protein localization (GO:0045176)2.47486578
94positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.46908580
95cell wall macromolecule catabolic process (GO:0016998)2.46781991
96resolution of meiotic recombination intermediates (GO:0000712)2.44298102
97axoneme assembly (GO:0035082)2.43390089
98negative regulation of astrocyte differentiation (GO:0048712)2.42838038
99positive regulation of DNA repair (GO:0045739)2.42595424
100determination of bilateral symmetry (GO:0009855)2.42103974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.15810803
2ZNF274_21170338_ChIP-Seq_K562_Hela3.54452593
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.52906660
4GBX2_23144817_ChIP-Seq_PC3_Human3.24444160
5FUS_26573619_Chip-Seq_HEK293_Human2.98468766
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87388096
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86088605
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60750739
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47583675
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46279735
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.31262539
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29019221
13VDR_22108803_ChIP-Seq_LS180_Human2.24771389
14EWS_26573619_Chip-Seq_HEK293_Human2.23383291
15P300_19829295_ChIP-Seq_ESCs_Human2.19321467
16IGF1R_20145208_ChIP-Seq_DFB_Human2.15812908
17EZH2_22144423_ChIP-Seq_EOC_Human2.06402230
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.96458704
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92390013
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89749325
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82212605
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81669616
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79027981
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79027981
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76393870
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73716326
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72850075
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69500696
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68156565
30SMAD4_21799915_ChIP-Seq_A2780_Human1.63237233
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.62953589
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59966073
33ER_23166858_ChIP-Seq_MCF-7_Human1.57339502
34BCAT_22108803_ChIP-Seq_LS180_Human1.57193257
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55941560
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.55599755
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55103013
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52591341
39STAT3_23295773_ChIP-Seq_U87_Human1.52485341
40IRF1_19129219_ChIP-ChIP_H3396_Human1.52473593
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49962996
42RNF2_27304074_Chip-Seq_NSC_Mouse1.49023431
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47731815
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43645075
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42145580
46TCF4_23295773_ChIP-Seq_U87_Human1.41835790
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.41350959
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.38974681
49MYC_18940864_ChIP-ChIP_HL60_Human1.37912467
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37671200
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35874157
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34401428
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.34003702
54TAF15_26573619_Chip-Seq_HEK293_Human1.33976021
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31724276
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30959454
57ELK1_19687146_ChIP-ChIP_HELA_Human1.30593912
58TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27278027
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25330664
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24171579
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23990168
62CBP_20019798_ChIP-Seq_JUKART_Human1.19334164
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19334164
64TCF4_22108803_ChIP-Seq_LS180_Human1.18959424
65AR_25329375_ChIP-Seq_VCAP_Human1.18900587
66RUNX2_22187159_ChIP-Seq_PCA_Human1.18594157
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17417173
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.17320858
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16938157
70P53_22387025_ChIP-Seq_ESCs_Mouse1.13045771
71KDM2B_26808549_Chip-Seq_REH_Human1.12267764
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.11977484
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11961964
74SOX2_19829295_ChIP-Seq_ESCs_Human1.11891726
75NANOG_19829295_ChIP-Seq_ESCs_Human1.11891726
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08952287
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08613225
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07631591
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07449666
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.07308824
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06980371
82JUN_21703547_ChIP-Seq_K562_Human1.06885684
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06409646
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.06054980
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.05964327
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.04828212
87REST_21632747_ChIP-Seq_MESCs_Mouse1.03331941
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.02939519
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02905941
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01479252
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01389376
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.00816210
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.00299703
94EZH2_27304074_Chip-Seq_ESCs_Mouse0.99331408
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97757107
96TP53_22573176_ChIP-Seq_HFKS_Human0.96821518
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94986383
98FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93936432
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93690090
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93261001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.53151082
2MP0006292_abnormal_olfactory_placode3.28512371
3MP0002102_abnormal_ear_morphology2.96968371
4MP0008877_abnormal_DNA_methylation2.76025890
5MP0001986_abnormal_taste_sensitivity2.58863165
6MP0008789_abnormal_olfactory_epithelium2.29076546
7MP0003646_muscle_fatigue2.25543913
8MP0005394_taste/olfaction_phenotype2.14231393
9MP0005499_abnormal_olfactory_system2.14231393
10MP0003122_maternal_imprinting2.00959293
11MP0008058_abnormal_DNA_repair1.91685210
12MP0001984_abnormal_olfaction1.91199963
13MP0009046_muscle_twitch1.90817533
14MP0003880_abnormal_central_pattern1.90080000
15MP0003937_abnormal_limbs/digits/tail_de1.89090155
16MP0005551_abnormal_eye_electrophysiolog1.88489636
17MP0001529_abnormal_vocalization1.87161742
18MP0004133_heterotaxia1.81689309
19MP0000049_abnormal_middle_ear1.74343227
20MP0003283_abnormal_digestive_organ1.70199150
21MP0003121_genomic_imprinting1.68901346
22MP0004142_abnormal_muscle_tone1.68739158
23MP0002736_abnormal_nociception_after1.65892167
24MP0002272_abnormal_nervous_system1.63932831
25MP0000569_abnormal_digit_pigmentation1.63031816
26MP0002822_catalepsy1.60587353
27MP0005253_abnormal_eye_physiology1.59947470
28MP0006072_abnormal_retinal_apoptosis1.51840770
29MP0003119_abnormal_digestive_system1.46875678
30MP0001486_abnormal_startle_reflex1.45075049
31MP0002938_white_spotting1.42696066
32MP0000631_abnormal_neuroendocrine_gland1.41047845
33MP0003567_abnormal_fetal_cardiomyocyte1.39688839
34MP0002653_abnormal_ependyma_morphology1.39596613
35MP0002233_abnormal_nose_morphology1.37308459
36MP0003890_abnormal_embryonic-extraembry1.34487379
37MP0005645_abnormal_hypothalamus_physiol1.33747213
38MP0000516_abnormal_urinary_system1.33140114
39MP0005367_renal/urinary_system_phenotyp1.33140114
40MP0005248_abnormal_Harderian_gland1.31006812
41MP0001968_abnormal_touch/_nociception1.29287566
42MP0000778_abnormal_nervous_system1.28237153
43MP0002282_abnormal_trachea_morphology1.25763235
44MP0003755_abnormal_palate_morphology1.24980265
45MP0003011_delayed_dark_adaptation1.23757425
46MP0002751_abnormal_autonomic_nervous1.21450600
47MP0009384_cardiac_valve_regurgitation1.20235874
48MP0003136_yellow_coat_color1.19802188
49MP0002234_abnormal_pharynx_morphology1.19373865
50MP0010030_abnormal_orbit_morphology1.18553894
51MP0002876_abnormal_thyroid_physiology1.17099998
52MP0001764_abnormal_homeostasis1.15225064
53MP0002090_abnormal_vision1.14633935
54MP0003938_abnormal_ear_development1.12791886
55MP0009745_abnormal_behavioral_response1.12545260
56MP0002249_abnormal_larynx_morphology1.11704092
57MP0002734_abnormal_mechanical_nocicepti1.11688807
58MP0002557_abnormal_social/conspecific_i1.11359545
59MP0005365_abnormal_bile_salt1.10503138
60MP0003787_abnormal_imprinting1.10010900
61MP0009250_abnormal_appendicular_skeleto1.09575742
62MP0004145_abnormal_muscle_electrophysio1.09566642
63MP0009697_abnormal_copulation1.09259644
64MP0010094_abnormal_chromosome_stability1.08482705
65MP0001929_abnormal_gametogenesis1.07482750
66MP0001286_abnormal_eye_development1.07189400
67MP0005391_vision/eye_phenotype1.04505289
68MP0008057_abnormal_DNA_replication1.01349543
69MP0001293_anophthalmia1.00764153
70MP0002095_abnormal_skin_pigmentation1.00245607
71MP0003698_abnormal_male_reproductive0.99748865
72MP0003861_abnormal_nervous_system0.99454906
73MP0000462_abnormal_digestive_system0.99406880
74MP0001502_abnormal_circadian_rhythm0.97709999
75MP0002064_seizures0.97401554
76MP0003137_abnormal_impulse_conducting0.96985743
77MP0000566_synostosis0.94548091
78MP0002735_abnormal_chemical_nociception0.93816240
79MP0005195_abnormal_posterior_eye0.93163975
80MP0008995_early_reproductive_senescence0.92308795
81MP0008875_abnormal_xenobiotic_pharmacok0.91512229
82MP0002152_abnormal_brain_morphology0.88529305
83MP0002184_abnormal_innervation0.88512467
84MP0004134_abnormal_chest_morphology0.88469454
85MP0002277_abnormal_respiratory_mucosa0.87604636
86MP0001270_distended_abdomen0.87520224
87MP0002837_dystrophic_cardiac_calcinosis0.86326445
88MP0009053_abnormal_anal_canal0.86296441
89MP0002752_abnormal_somatic_nervous0.85707122
90MP0008961_abnormal_basal_metabolism0.84931933
91MP0000653_abnormal_sex_gland0.82400487
92MP0005670_abnormal_white_adipose0.80631672
93MP0003950_abnormal_plasma_membrane0.77340236
94MP0000026_abnormal_inner_ear0.76838319
95MP0002109_abnormal_limb_morphology0.76371331
96MP0003635_abnormal_synaptic_transmissio0.76338428
97MP0002697_abnormal_eye_size0.75337866
98MP0003718_maternal_effect0.75311413
99MP0002882_abnormal_neuron_morphology0.73601498
100MP0002210_abnormal_sex_determination0.73389559

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)3.85186201
2Abnormality of midbrain morphology (HP:0002418)3.85186201
3Progressive inability to walk (HP:0002505)3.84419699
4Chronic hepatic failure (HP:0100626)3.67304299
5Intestinal atresia (HP:0011100)3.65652598
6Colon cancer (HP:0003003)3.45995625
7Pancreatic cysts (HP:0001737)3.40212244
8Drooling (HP:0002307)3.09429767
9Medial flaring of the eyebrow (HP:0010747)2.92904589
10Pancreatic fibrosis (HP:0100732)2.92166766
11Vitreoretinal degeneration (HP:0000655)2.89680668
12Excessive salivation (HP:0003781)2.83591804
13Gait imbalance (HP:0002141)2.81336510
14Nephronophthisis (HP:0000090)2.74807628
15Congenital primary aphakia (HP:0007707)2.69083558
16True hermaphroditism (HP:0010459)2.69059975
17Neoplasm of the oral cavity (HP:0100649)2.67808753
18Febrile seizures (HP:0002373)2.66572992
19Hyperventilation (HP:0002883)2.65455763
20Abnormality of the renal medulla (HP:0100957)2.65328299
21Hepatocellular necrosis (HP:0001404)2.64267834
22Abolished electroretinogram (ERG) (HP:0000550)2.63070467
23Volvulus (HP:0002580)2.58853326
24Short 4th metacarpal (HP:0010044)2.58536527
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58536527
26Hepatoblastoma (HP:0002884)2.57803230
27Tented upper lip vermilion (HP:0010804)2.57491161
28Abnormality of the renal cortex (HP:0011035)2.55694459
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50686037
30Septo-optic dysplasia (HP:0100842)2.49095571
31Spontaneous abortion (HP:0005268)2.48389685
32Nephrogenic diabetes insipidus (HP:0009806)2.48159531
33Genital tract atresia (HP:0001827)2.45250835
34Optic nerve hypoplasia (HP:0000609)2.44917784
35Inability to walk (HP:0002540)2.40866354
36Tubulointerstitial nephritis (HP:0001970)2.40541511
37Abnormality of the labia minora (HP:0012880)2.35543479
38Epidermoid cyst (HP:0200040)2.33491961
39Vaginal atresia (HP:0000148)2.32341155
40Bile duct proliferation (HP:0001408)2.28119614
41Abnormal biliary tract physiology (HP:0012439)2.28119614
42Cortical dysplasia (HP:0002539)2.26166727
43Renal cortical cysts (HP:0000803)2.25489323
44Abnormal lung lobation (HP:0002101)2.21719495
45Medulloblastoma (HP:0002885)2.20128539
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19410573
47Hepatic necrosis (HP:0002605)2.18599036
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15931153
49Abnormality of alanine metabolism (HP:0010916)2.15931153
50Hyperalaninemia (HP:0003348)2.15931153
51Acute necrotizing encephalopathy (HP:0006965)2.11641893
52Intellectual disability, moderate (HP:0002342)2.07546524
53Gastrointestinal atresia (HP:0002589)2.03236788
54Hyperglycinemia (HP:0002154)2.02823964
55Delayed CNS myelination (HP:0002188)2.00727654
56Split foot (HP:0001839)1.98815324
57Cystic liver disease (HP:0006706)1.98316599
58Bifid tongue (HP:0010297)1.95350035
59Abnormality of the ileum (HP:0001549)1.94990662
60Abnormality of chromosome stability (HP:0003220)1.94680525
61Abnormality of the 4th metacarpal (HP:0010012)1.93721062
62Small hand (HP:0200055)1.91711194
63Attenuation of retinal blood vessels (HP:0007843)1.91684411
64Postaxial hand polydactyly (HP:0001162)1.90885559
65Aplasia/Hypoplasia of the uvula (HP:0010293)1.90782420
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.90591776
67Abnormal rod and cone electroretinograms (HP:0008323)1.90337963
68Sloping forehead (HP:0000340)1.89261637
69Acute encephalopathy (HP:0006846)1.87530416
70Renal hypoplasia (HP:0000089)1.86772405
71Cupped ear (HP:0000378)1.86279705
72Supernumerary spleens (HP:0009799)1.84480757
73Progressive macrocephaly (HP:0004481)1.83584940
74Postaxial foot polydactyly (HP:0001830)1.83436167
75Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80208097
76Asplenia (HP:0001746)1.79912954
77Meckel diverticulum (HP:0002245)1.79157765
78Ulnar claw (HP:0001178)1.78936898
79Micropenis (HP:0000054)1.78170371
80Long clavicles (HP:0000890)1.75612400
81CNS demyelination (HP:0007305)1.72049469
82Astigmatism (HP:0000483)1.72039822
83Tubular atrophy (HP:0000092)1.71448496
84Absent speech (HP:0001344)1.70778352
85Renal dysplasia (HP:0000110)1.70570053
86Poor coordination (HP:0002370)1.70141100
87Abnormality of the duodenum (HP:0002246)1.70069173
88Pancreatic islet-cell hyperplasia (HP:0004510)1.70017737
89Hypoplastic iliac wings (HP:0002866)1.69816548
90Epileptic encephalopathy (HP:0200134)1.69490790
91Absent septum pellucidum (HP:0001331)1.69481312
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.69104808
93Broad-based gait (HP:0002136)1.67656697
94Hypoplastic ischia (HP:0003175)1.67578891
95Mitochondrial inheritance (HP:0001427)1.67419176
96Cerebral edema (HP:0002181)1.66663037
97Ectopic kidney (HP:0000086)1.66041277
98Enlarged kidneys (HP:0000105)1.65501903
99Disproportionate short-trunk short stature (HP:0003521)1.64771279
100Lissencephaly (HP:0001339)1.63875176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.47384975
2CCNB13.17552769
3MAP3K43.06839334
4MAPK132.93876113
5NUAK12.89620407
6WNK32.76867924
7CASK2.56088632
8EPHA42.36441504
9BMPR1B2.35171201
10WEE12.24477722
11GRK12.18678070
12TNIK2.17755890
13MARK11.99691068
14MAP2K71.95591587
15TAF11.77591609
16ACVR1B1.69569116
17NTRK21.65805170
18MKNK21.63167834
19EPHA31.61614504
20MAP4K21.61114206
21PRKD31.59456179
22PLK41.54513968
23PNCK1.54406327
24SRPK11.54266602
25ADRBK21.49693251
26CDC71.46712592
27AKT31.44868301
28PRKCG1.42485818
29PAK31.41185637
30PBK1.37619207
31FGFR21.32816315
32RPS6KA41.30154012
33PLK31.24921512
34PLK21.24023066
35PINK11.17679081
36DYRK21.17111552
37PRKCE1.14830366
38CSNK1G11.13558123
39BCKDK1.10766356
40PLK11.08722474
41VRK11.08086687
42NME11.06491755
43CSNK1G21.05083063
44BCR1.05055933
45DYRK31.01822515
46STK391.01480276
47INSRR0.98642167
48SGK20.97965550
49MKNK10.97493487
50CSNK1A1L0.96090985
51CSNK1G30.94430424
52EPHB20.89752349
53STK38L0.89690576
54ZAK0.89128063
55TTK0.89066686
56OXSR10.86216495
57NEK10.84997052
58WNK40.82993081
59NTRK30.80391356
60PDK20.77989217
61TRIM280.73611539
62LATS10.71335801
63MAP2K40.70634931
64ERBB30.70329473
65NEK20.67186419
66PRKG10.66414148
67SGK2230.66042592
68SGK4940.66042592
69TGFBR10.65806365
70FLT30.65136424
71BUB10.64983514
72ATR0.57860900
73OBSCN0.51348959
74MAPKAPK50.51110043
75CDK90.48224914
76SGK30.45477929
77VRK20.43244492
78ATM0.42933171
79PRKACA0.42746828
80BRSK20.42680859
81CSNK1A10.42360409
82CSNK1D0.42068175
83CAMK2A0.39597173
84PRKCH0.38832543
85STK110.38738462
86PRKACB0.37316907
87RPS6KB10.36779378
88SGK10.36146680
89MINK10.33351349
90PRKAA10.32087235
91CSNK1E0.31423921
92CSNK2A10.31397630
93TIE10.31294083
94CHEK10.31003864
95PRKCZ0.30731646
96RPS6KA10.30688754
97MAPK150.28192249
98MARK30.26862296
99CDK10.26418221
100DYRK1A0.26094882

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.08400485
2Nicotine addiction_Homo sapiens_hsa050332.96061065
3Fanconi anemia pathway_Homo sapiens_hsa034602.75567490
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.72065802
5Caffeine metabolism_Homo sapiens_hsa002322.51445974
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47297057
7Butanoate metabolism_Homo sapiens_hsa006502.36147279
8Protein export_Homo sapiens_hsa030602.29034619
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23370569
10Propanoate metabolism_Homo sapiens_hsa006402.18890693
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17775789
12Linoleic acid metabolism_Homo sapiens_hsa005912.15126783
13Homologous recombination_Homo sapiens_hsa034402.11047210
14Phototransduction_Homo sapiens_hsa047442.08281840
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07144851
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.00709301
17Nitrogen metabolism_Homo sapiens_hsa009101.97913704
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76810490
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70875030
20Basal transcription factors_Homo sapiens_hsa030221.67202012
21Morphine addiction_Homo sapiens_hsa050321.55689128
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49480677
23Ether lipid metabolism_Homo sapiens_hsa005651.39807790
24Taste transduction_Homo sapiens_hsa047421.39168094
25Oxidative phosphorylation_Homo sapiens_hsa001901.36717585
26Peroxisome_Homo sapiens_hsa041461.33046798
27Glutamatergic synapse_Homo sapiens_hsa047241.30132431
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28899239
29Fat digestion and absorption_Homo sapiens_hsa049751.22689608
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21367169
31Hedgehog signaling pathway_Homo sapiens_hsa043401.19684549
32GABAergic synapse_Homo sapiens_hsa047271.19118118
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18657301
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.18246568
35Olfactory transduction_Homo sapiens_hsa047401.18225928
36Chemical carcinogenesis_Homo sapiens_hsa052041.17921318
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13318807
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11888931
39Vitamin digestion and absorption_Homo sapiens_hsa049771.10166241
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09989787
41Base excision repair_Homo sapiens_hsa034101.07497337
42Glutathione metabolism_Homo sapiens_hsa004801.05741171
43Parkinsons disease_Homo sapiens_hsa050121.05161522
44beta-Alanine metabolism_Homo sapiens_hsa004101.03311182
45Fatty acid degradation_Homo sapiens_hsa000711.02491746
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.02468356
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01647427
48Circadian entrainment_Homo sapiens_hsa047130.98448966
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.98228115
50Tryptophan metabolism_Homo sapiens_hsa003800.97666164
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96486864
52RNA degradation_Homo sapiens_hsa030180.95869024
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94501193
54Serotonergic synapse_Homo sapiens_hsa047260.93160315
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92773330
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89574400
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88511594
58Basal cell carcinoma_Homo sapiens_hsa052170.85818133
59RNA transport_Homo sapiens_hsa030130.82883412
60Retinol metabolism_Homo sapiens_hsa008300.82337022
61Nucleotide excision repair_Homo sapiens_hsa034200.81071882
62Arachidonic acid metabolism_Homo sapiens_hsa005900.80520379
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80347608
64Axon guidance_Homo sapiens_hsa043600.79294865
65Lysine degradation_Homo sapiens_hsa003100.77786783
66TGF-beta signaling pathway_Homo sapiens_hsa043500.76909159
67Mismatch repair_Homo sapiens_hsa034300.74591083
68ABC transporters_Homo sapiens_hsa020100.73140922
69Dopaminergic synapse_Homo sapiens_hsa047280.70362692
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66131301
71Huntingtons disease_Homo sapiens_hsa050160.65792953
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64928366
73PPAR signaling pathway_Homo sapiens_hsa033200.62048816
74Purine metabolism_Homo sapiens_hsa002300.61198883
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.61137127
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59212925
77Cardiac muscle contraction_Homo sapiens_hsa042600.58913597
78mRNA surveillance pathway_Homo sapiens_hsa030150.55453510
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54528973
80Metabolic pathways_Homo sapiens_hsa011000.54463096
81Histidine metabolism_Homo sapiens_hsa003400.54281390
82RNA polymerase_Homo sapiens_hsa030200.52306422
83Spliceosome_Homo sapiens_hsa030400.52182501
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52074405
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50450985
86Circadian rhythm_Homo sapiens_hsa047100.49576681
87Ovarian steroidogenesis_Homo sapiens_hsa049130.48382011
88Hippo signaling pathway_Homo sapiens_hsa043900.47891971
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44552408
90Long-term depression_Homo sapiens_hsa047300.43968509
91Insulin secretion_Homo sapiens_hsa049110.43353048
92Fatty acid metabolism_Homo sapiens_hsa012120.43339877
93Amphetamine addiction_Homo sapiens_hsa050310.38983857
94Alzheimers disease_Homo sapiens_hsa050100.37535502
95Cholinergic synapse_Homo sapiens_hsa047250.37508187
96Glycerolipid metabolism_Homo sapiens_hsa005610.36383933
97Cell cycle_Homo sapiens_hsa041100.35635670
98Gastric acid secretion_Homo sapiens_hsa049710.35397979
99Pyruvate metabolism_Homo sapiens_hsa006200.34899316
100Collecting duct acid secretion_Homo sapiens_hsa049660.34023602

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