CCT5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.29821623
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.29821623
3homocysteine metabolic process (GO:0050667)5.71306533
4folic acid-containing compound biosynthetic process (GO:0009396)5.36160721
5rRNA methylation (GO:0031167)5.25908102
6epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.25466493
7mitochondrial RNA metabolic process (GO:0000959)4.89943016
8DNA deamination (GO:0045006)4.75962873
9rRNA modification (GO:0000154)4.71142971
10purine nucleotide salvage (GO:0032261)4.59810952
11proteasome assembly (GO:0043248)4.59362604
12regulation of plasminogen activation (GO:0010755)4.28911447
13negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)4.28599605
14microtubule nucleation (GO:0007020)4.20136932
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.17540782
16adenosine metabolic process (GO:0046085)4.11521002
17water-soluble vitamin biosynthetic process (GO:0042364)3.94656245
18behavioral response to nicotine (GO:0035095)3.89166259
19L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.87547202
20white fat cell differentiation (GO:0050872)3.81962132
21alternative mRNA splicing, via spliceosome (GO:0000380)3.77545776
22regulation of helicase activity (GO:0051095)3.76609975
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67618338
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.67618338
25NADH dehydrogenase complex assembly (GO:0010257)3.67618338
26CENP-A containing nucleosome assembly (GO:0034080)3.66164371
27negative regulation of DNA biosynthetic process (GO:2000279)3.64888882
28pteridine-containing compound biosynthetic process (GO:0042559)3.60021234
29ribosome biogenesis (GO:0042254)3.60013958
30cysteine metabolic process (GO:0006534)3.57600940
31negative regulation of signal transduction by p53 class mediator (GO:1901797)3.54677965
32IMP biosynthetic process (GO:0006188)3.53725058
33chromatin remodeling at centromere (GO:0031055)3.51209841
34DNA double-strand break processing (GO:0000729)3.49994432
35basic amino acid transport (GO:0015802)3.47361454
36regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.42033585
37negative regulation of keratinocyte proliferation (GO:0010839)3.40514276
38protein complex biogenesis (GO:0070271)3.37173822
39sulfur amino acid catabolic process (GO:0000098)3.32823218
40protein-chromophore linkage (GO:0018298)3.29432253
41sulfur amino acid biosynthetic process (GO:0000097)3.22611972
42amino acid salvage (GO:0043102)3.21640859
43L-methionine salvage (GO:0071267)3.21640859
44L-methionine biosynthetic process (GO:0071265)3.21640859
45mitochondrial respiratory chain complex assembly (GO:0033108)3.19309435
46cytidine metabolic process (GO:0046087)3.18783325
47cytidine catabolic process (GO:0006216)3.18783325
48cytidine deamination (GO:0009972)3.18783325
49termination of RNA polymerase III transcription (GO:0006386)3.15980156
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.15980156
51sulfation (GO:0051923)3.14249647
52cellular response to ATP (GO:0071318)3.10040676
53positive regulation of endothelial cell differentiation (GO:0045603)3.08290815
54tRNA modification (GO:0006400)3.05854396
55cartilage morphogenesis (GO:0060536)3.05676030
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05456910
57platelet dense granule organization (GO:0060155)3.04128933
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03698925
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02171779
60indolalkylamine metabolic process (GO:0006586)3.00574224
61inner ear receptor cell development (GO:0060119)2.98716735
62pseudouridine synthesis (GO:0001522)2.98578611
63histone exchange (GO:0043486)2.98337051
64regulation of sequestering of triglyceride (GO:0010889)2.98216810
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97577753
66kynurenine metabolic process (GO:0070189)2.96602880
67protein-cofactor linkage (GO:0018065)2.94013234
68tRNA processing (GO:0008033)2.93792762
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93730965
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93730965
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93730965
72L-serine metabolic process (GO:0006563)2.92963571
73primary amino compound metabolic process (GO:1901160)2.92289747
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92268087
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92268087
76tetrahydrofolate metabolic process (GO:0046653)2.91614784
77galactose metabolic process (GO:0006012)2.91414987
78regulation of tight junction assembly (GO:2000810)2.90607884
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88574453
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84708524
81folic acid-containing compound metabolic process (GO:0006760)2.84551874
82rRNA catabolic process (GO:0016075)2.83999472
83muscle atrophy (GO:0014889)2.83871063
84IMP metabolic process (GO:0046040)2.83686887
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.83564981
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.83564981
87signal transduction involved in cell cycle checkpoint (GO:0072395)2.81562845
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80737934
89tryptophan catabolic process (GO:0006569)2.76979989
90indole-containing compound catabolic process (GO:0042436)2.76979989
91indolalkylamine catabolic process (GO:0046218)2.76979989
92negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.75302143
93regulation of cellular amino acid metabolic process (GO:0006521)2.73468344
94cardiac epithelial to mesenchymal transition (GO:0060317)2.72552266
95protein neddylation (GO:0045116)2.72537899
96cellular response to zinc ion (GO:0071294)2.71355358
97cullin deneddylation (GO:0010388)2.70164975
98transcription from mitochondrial promoter (GO:0006390)2.68996868
99organic cation transport (GO:0015695)2.67391231
100negative regulation of ligase activity (GO:0051352)2.67368708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.99949032
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.81800003
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31181588
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.86059331
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84025283
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75262172
7ELK1_19687146_ChIP-ChIP_HELA_Human2.57964566
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50067682
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32868141
10ZNF274_21170338_ChIP-Seq_K562_Hela2.29244870
11EWS_26573619_Chip-Seq_HEK293_Human2.22910397
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse10.0306887
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93899170
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90771530
15VDR_23849224_ChIP-Seq_CD4+_Human1.90756008
16PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90685905
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.88620968
18FUS_26573619_Chip-Seq_HEK293_Human1.86098354
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.83659160
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81935800
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.79375601
22E2F7_22180533_ChIP-Seq_HELA_Human1.78863962
23EZH2_22144423_ChIP-Seq_EOC_Human1.78802008
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71188559
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61980193
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61368609
27TAF15_26573619_Chip-Seq_HEK293_Human1.59313288
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58476612
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57358922
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52476069
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.48109183
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47965990
33NCOR_22424771_ChIP-Seq_293T_Human1.46564704
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45635363
35FOXP3_21729870_ChIP-Seq_TREG_Human1.45168726
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43592160
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.43574852
38CDX2_22108803_ChIP-Seq_LS180_Human1.43496182
39P300_19829295_ChIP-Seq_ESCs_Human1.42183802
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41348123
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41316024
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32409084
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31879275
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31183373
45TP53_22573176_ChIP-Seq_HFKS_Human1.30592115
46BCAT_22108803_ChIP-Seq_LS180_Human1.27797603
47MYC_18940864_ChIP-ChIP_HL60_Human1.24911460
48CBP_20019798_ChIP-Seq_JUKART_Human1.21703299
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21703299
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21097624
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19639056
52TCF4_22108803_ChIP-Seq_LS180_Human1.18850332
53GABP_19822575_ChIP-Seq_HepG2_Human1.16715500
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16031521
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15424869
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14097247
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12451564
58ER_23166858_ChIP-Seq_MCF-7_Human1.12085433
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.09833082
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05115781
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.05057905
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04970260
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04785677
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04170894
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.02883379
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02436333
67NANOG_19829295_ChIP-Seq_ESCs_Human1.02188704
68SOX2_19829295_ChIP-Seq_ESCs_Human1.02188704
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00566052
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99898012
71YY1_21170310_ChIP-Seq_MESCs_Mouse0.97471022
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96923256
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95547326
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94095910
75NFE2_27457419_Chip-Seq_LIVER_Mouse0.93043726
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93012225
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.92995071
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90290188
79MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90042881
80DCP1A_22483619_ChIP-Seq_HELA_Human0.89351726
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89133945
82CRX_20693478_ChIP-Seq_RETINA_Mouse0.87981359
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87499567
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87223759
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86830109
86AR_20517297_ChIP-Seq_VCAP_Human0.85701042
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84824650
88HOXB7_26014856_ChIP-Seq_BT474_Human0.84433213
89E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81080709
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80729713
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.80729713
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80552335
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.79484117
94GBX2_23144817_ChIP-Seq_PC3_Human0.79397094
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78849857
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78179110
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.77968199
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77581065
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.77490293
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.76926599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph3.68318231
2MP0005670_abnormal_white_adipose3.16941898
3MP0005360_urolithiasis2.97135366
4MP0008058_abnormal_DNA_repair2.86636811
5MP0005646_abnormal_pituitary_gland2.81684846
6MP0002138_abnormal_hepatobiliary_system2.58089317
7MP0004147_increased_porphyrin_level2.52752769
8MP0002736_abnormal_nociception_after2.44486790
9MP0008995_early_reproductive_senescence2.32835592
10MP0003646_muscle_fatigue2.27822947
11MP0001968_abnormal_touch/_nociception2.19237040
12MP0003195_calcinosis2.18264478
13MP0009697_abnormal_copulation2.09267271
14MP0003786_premature_aging2.07161197
15MP0004145_abnormal_muscle_electrophysio2.05286329
16MP0002160_abnormal_reproductive_system2.01961108
17MP0008872_abnormal_physiological_respon2.00951276
18MP0004134_abnormal_chest_morphology1.93559011
19MP0003693_abnormal_embryo_hatching1.90523153
20MP0003806_abnormal_nucleotide_metabolis1.86811103
21MP0002095_abnormal_skin_pigmentation1.81084260
22MP0000747_muscle_weakness1.75940252
23MP0000372_irregular_coat_pigmentation1.74358524
24MP0005083_abnormal_biliary_tract1.67266472
25MP0008057_abnormal_DNA_replication1.66760010
26MP0005551_abnormal_eye_electrophysiolog1.66452482
27MP0006054_spinal_hemorrhage1.58549797
28MP0000013_abnormal_adipose_tissue1.57632412
29MP0010094_abnormal_chromosome_stability1.54784920
30MP0003705_abnormal_hypodermis_morpholog1.50105071
31MP0006072_abnormal_retinal_apoptosis1.49284486
32MP0002735_abnormal_chemical_nociception1.47362693
33MP0002938_white_spotting1.45073192
34MP0005367_renal/urinary_system_phenotyp1.45051805
35MP0000516_abnormal_urinary_system1.45051805
36MP0001661_extended_life_span1.43419313
37MP0002396_abnormal_hematopoietic_system1.42370655
38MP0003111_abnormal_nucleus_morphology1.39155630
39MP0004043_abnormal_pH_regulation1.34443079
40MP0001119_abnormal_female_reproductive1.34151162
41MP0003186_abnormal_redox_activity1.32496155
42MP0005410_abnormal_fertilization1.28608592
43MP0003880_abnormal_central_pattern1.28141749
44MP0003718_maternal_effect1.26662830
45MP0002210_abnormal_sex_determination1.26043095
46MP0006276_abnormal_autonomic_nervous1.25770320
47MP0001486_abnormal_startle_reflex1.25560108
48MP0003077_abnormal_cell_cycle1.22237067
49MP0002102_abnormal_ear_morphology1.21033967
50MP0005253_abnormal_eye_physiology1.20304962
51MP0003950_abnormal_plasma_membrane1.19855793
52MP0005171_absent_coat_pigmentation1.19239789
53MP0000653_abnormal_sex_gland1.19019666
54MP0004957_abnormal_blastocyst_morpholog1.18625915
55MP0000749_muscle_degeneration1.18447222
56MP0005389_reproductive_system_phenotype1.18091728
57MP0000631_abnormal_neuroendocrine_gland1.16550880
58MP0000647_abnormal_sebaceous_gland1.16327471
59MP0002269_muscular_atrophy1.11202045
60MP0008877_abnormal_DNA_methylation1.10688794
61MP0002638_abnormal_pupillary_reflex1.07061125
62MP0008789_abnormal_olfactory_epithelium1.07035402
63MP0006292_abnormal_olfactory_placode1.06760069
64MP0001485_abnormal_pinna_reflex1.04388517
65MP0009333_abnormal_splenocyte_physiolog1.00086092
66MP0004215_abnormal_myocardial_fiber0.99757134
67MP0009250_abnormal_appendicular_skeleto0.98226260
68MP0005332_abnormal_amino_acid0.97838938
69MP0004185_abnormal_adipocyte_glucose0.97261969
70MP0001929_abnormal_gametogenesis0.94966026
71MP0002295_abnormal_pulmonary_circulatio0.94619119
72MP0000026_abnormal_inner_ear0.94416590
73MP0001145_abnormal_male_reproductive0.92026367
74MP0009745_abnormal_behavioral_response0.91167835
75MP0004142_abnormal_muscle_tone0.91144251
76MP0003890_abnormal_embryonic-extraembry0.90224218
77MP0005671_abnormal_response_to0.88789537
78MP0006035_abnormal_mitochondrial_morpho0.85672518
79MP0001502_abnormal_circadian_rhythm0.84188843
80MP0005084_abnormal_gallbladder_morpholo0.84036118
81MP0001963_abnormal_hearing_physiology0.81294016
82MP0000049_abnormal_middle_ear0.80506559
83MP0006036_abnormal_mitochondrial_physio0.78930226
84MP0001440_abnormal_grooming_behavior0.78412196
85MP0003638_abnormal_response/metabolism_0.78261755
86MP0009046_muscle_twitch0.77945003
87MP0003315_abnormal_perineum_morphology0.77656246
88MP0003942_abnormal_urinary_system0.77558805
89MP0002272_abnormal_nervous_system0.76789616
90MP0003936_abnormal_reproductive_system0.71814582
91MP0004130_abnormal_muscle_cell0.70758630
92MP0002733_abnormal_thermal_nociception0.70170015
93MP0000371_diluted_coat_color0.69318548
94MP0001986_abnormal_taste_sensitivity0.69246831
95MP0002653_abnormal_ependyma_morphology0.67853864
96MP0002184_abnormal_innervation0.64993615
97MP0003045_fibrosis0.63046590
98MP0003011_delayed_dark_adaptation0.61857368
99MP0003698_abnormal_male_reproductive0.59276835
100MP0008775_abnormal_heart_ventricle0.58999207

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)7.46434975
2Hyperalaninemia (HP:0003348)7.46434975
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.46434975
4Congenital sensorineural hearing impairment (HP:0008527)4.60329740
5Constricted visual fields (HP:0001133)4.56817338
6Decreased electroretinogram (ERG) amplitude (HP:0000654)4.09442730
7Attenuation of retinal blood vessels (HP:0007843)3.90012403
8Abnormality of serum amino acid levels (HP:0003112)3.41680288
9Pendular nystagmus (HP:0012043)3.37679258
10Abnormality of homocysteine metabolism (HP:0010919)3.34551091
11Homocystinuria (HP:0002156)3.34551091
12Action tremor (HP:0002345)3.33878187
13Conjugated hyperbilirubinemia (HP:0002908)3.12501405
14Birth length less than 3rd percentile (HP:0003561)3.02069834
15Increased serum lactate (HP:0002151)2.83889664
16Abnormal umbilical cord blood vessels (HP:0011403)2.78410489
17Single umbilical artery (HP:0001195)2.78410489
18Abnormality of the fetal cardiovascular system (HP:0010948)2.78410489
19Ileus (HP:0002595)2.77666199
20Anorexia (HP:0002039)2.76896601
21Reduced subcutaneous adipose tissue (HP:0003758)2.76444147
22Pancreatic cysts (HP:0001737)2.75699439
23Small hand (HP:0200055)2.72408170
24Esophageal varix (HP:0002040)2.66102759
25Decreased central vision (HP:0007663)2.63379986
26White forelock (HP:0002211)2.57433589
27Patchy hypopigmentation of hair (HP:0011365)2.56202272
28Increased CSF lactate (HP:0002490)2.56048828
29Methylmalonic acidemia (HP:0002912)2.55299612
30Acute necrotizing encephalopathy (HP:0006965)2.39297017
31Abolished electroretinogram (ERG) (HP:0000550)2.37225682
32Congenital stationary night blindness (HP:0007642)2.37179308
33Poor speech (HP:0002465)2.36058030
34Aplasia/hypoplasia of the uterus (HP:0008684)2.33959150
35Spontaneous hematomas (HP:0007420)2.31648015
36Abnormality of midbrain morphology (HP:0002418)2.30638974
37Molar tooth sign on MRI (HP:0002419)2.30638974
38Increased corneal curvature (HP:0100692)2.29975018
39Keratoconus (HP:0000563)2.29975018
40Hypoplasia of the uterus (HP:0000013)2.28318362
41Pancreatic fibrosis (HP:0100732)2.25445407
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.25327561
43Chorioretinal atrophy (HP:0000533)2.25051226
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22123442
45Aplastic anemia (HP:0001915)2.19436219
46Limb dystonia (HP:0002451)2.16439768
47Abnormality of the umbilical cord (HP:0010881)2.15375463
48Abnormality of the labia minora (HP:0012880)2.14211289
49Conjunctival telangiectasia (HP:0000524)2.13825967
503-Methylglutaconic aciduria (HP:0003535)2.13453656
51Conjunctival hamartoma (HP:0100780)2.12571253
52True hermaphroditism (HP:0010459)2.10495736
53Progressive macrocephaly (HP:0004481)2.09411359
54Mitochondrial inheritance (HP:0001427)2.09257336
55Abnormal mitochondria in muscle tissue (HP:0008316)2.06593651
56Cerebral hypomyelination (HP:0006808)2.03250180
57Optic disc pallor (HP:0000543)2.02082986
58Chronic hepatic failure (HP:0100626)2.01258535
59Pigmentary retinal degeneration (HP:0001146)2.00303226
60Cavernous hemangioma (HP:0001048)1.97516699
61Insulin-resistant diabetes mellitus (HP:0000831)1.93536553
62Metabolic acidosis (HP:0001942)1.93333258
63Progressive cerebellar ataxia (HP:0002073)1.92804607
64Acute encephalopathy (HP:0006846)1.90404102
65Myocardial infarction (HP:0001658)1.89211043
66Hepatocellular necrosis (HP:0001404)1.86864748
67Arteriovenous malformation (HP:0100026)1.85389905
68Pulmonary embolism (HP:0002204)1.85326662
69Aplasia/Hypoplasia of the patella (HP:0006498)1.85094117
70Abnormality of the renal collecting system (HP:0004742)1.83322199
71Colon cancer (HP:0003003)1.83162987
72Premature ovarian failure (HP:0008209)1.83104440
73Stenosis of the external auditory canal (HP:0000402)1.82693589
74Decreased circulating renin level (HP:0003351)1.81943987
75Lethargy (HP:0001254)1.80184254
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77330990
77Lactic acidosis (HP:0003128)1.77252063
78Anencephaly (HP:0002323)1.76350235
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.75080926
80Nausea (HP:0002018)1.74417439
81Delayed CNS myelination (HP:0002188)1.73034631
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72871818
83Hyperglycinemia (HP:0002154)1.72334161
84Increased serum pyruvate (HP:0003542)1.71340417
85Amniotic constriction ring (HP:0009775)1.71334159
86Abnormality of placental membranes (HP:0011409)1.71334159
87Cerebral edema (HP:0002181)1.71326207
88Abnormalities of placenta or umbilical cord (HP:0001194)1.70691483
89Bony spicule pigmentary retinopathy (HP:0007737)1.69547077
90Unsteady gait (HP:0002317)1.68605418
91Short tibia (HP:0005736)1.67832543
92Decreased subcutaneous fat (HP:0001002)1.67493560
93Methylmalonic aciduria (HP:0012120)1.66520122
94Hypothermia (HP:0002045)1.66145085
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.64783435
96Patellar aplasia (HP:0006443)1.63758849
97Ectopic kidney (HP:0000086)1.63650905
98Microretrognathia (HP:0000308)1.63349448
99Abnormality of methionine metabolism (HP:0010901)1.61674432
100Abnormal rod and cone electroretinograms (HP:0008323)1.61056883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.42280921
2VRK23.77557259
3NUAK13.49265658
4EIF2AK32.87761938
5BUB12.79195387
6TAF12.43201691
7MST42.28384366
8WNK32.18808806
9TXK2.15391182
10VRK12.02797607
11CDK91.93988468
12MKNK21.92674080
13FRK1.79562446
14MAP3K31.74936795
15NEK11.74077571
16ACVR1B1.65485509
17MAP3K111.65279946
18MUSK1.62874456
19CCNB11.62711985
20PDK21.56431834
21PLK31.50391065
22ZAK1.48416120
23PLK41.45273326
24GRK11.31368076
25BMPR1B1.26989355
26TIE11.24868179
27EIF2AK11.23312692
28ADRBK21.21721744
29OXSR11.20296054
30CSNK1G31.14652191
31PLK21.13309847
32MKNK11.10285636
33DYRK21.06310213
34CSNK1G21.03022133
35MAPKAPK51.02534583
36EPHB21.01875568
37PHKG11.01521412
38PHKG21.01521412
39TRIM281.00312717
40KDR0.97742881
41PBK0.95425962
42JAK30.93697600
43ADRBK10.93475943
44CSNK1A1L0.92557839
45MAP2K30.92489581
46CSNK1G10.90817539
47MAP2K60.88763049
48TSSK60.88678596
49BCKDK0.84202499
50SRPK10.81929973
51STK160.78993608
52CSNK1A10.76939241
53MAP2K40.74681094
54AURKA0.74077091
55EIF2AK20.72995206
56STK390.72909133
57MAPK130.72780432
58DAPK10.72431184
59WNK40.71171017
60MAP3K50.63464708
61ATR0.63380411
62BRSK10.61551827
63PLK10.61175049
64AKT30.61074116
65TTK0.60612736
66FGR0.60530892
67GRK50.58657234
68OBSCN0.58389947
69CHEK20.56416970
70INSRR0.52238502
71SGK20.51710096
72CAMK2A0.51472769
73SGK4940.51248369
74SGK2230.51248369
75NTRK20.51156975
76BRD40.50467817
77TNIK0.48904582
78BRSK20.48274497
79PRKCE0.46517765
80CASK0.46474934
81TLK10.43974195
82PRKCI0.43878918
83CSNK2A10.39496164
84STK100.39223027
85RPS6KB20.38778174
86DYRK1A0.36224585
87WEE10.35654586
88AURKB0.35584626
89TESK20.33734126
90PRKCQ0.33701628
91MAP4K20.33432617
92NEK90.33011600
93PINK10.32976695
94PRKACA0.32096199
95PAK10.30506903
96PRKCA0.29378582
97TAOK30.28121246
98MAPKAPK30.28115185
99PIM10.27424643
100DYRK30.27177803

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.67927676
2One carbon pool by folate_Homo sapiens_hsa006703.38484991
3RNA polymerase_Homo sapiens_hsa030202.76460138
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.56440532
5Basal transcription factors_Homo sapiens_hsa030222.55633035
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37338370
7Sulfur metabolism_Homo sapiens_hsa009202.37172525
8Protein export_Homo sapiens_hsa030602.34284705
9Oxidative phosphorylation_Homo sapiens_hsa001902.22539128
10RNA degradation_Homo sapiens_hsa030181.85993609
11Cysteine and methionine metabolism_Homo sapiens_hsa002701.84984893
12Nicotine addiction_Homo sapiens_hsa050331.81905758
13Sulfur relay system_Homo sapiens_hsa041221.79636826
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77990377
15Parkinsons disease_Homo sapiens_hsa050121.77839076
16Nitrogen metabolism_Homo sapiens_hsa009101.65277116
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61693838
18Arginine biosynthesis_Homo sapiens_hsa002201.50517337
19Homologous recombination_Homo sapiens_hsa034401.49560131
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48981985
21Fanconi anemia pathway_Homo sapiens_hsa034601.46764693
22Selenocompound metabolism_Homo sapiens_hsa004501.46011156
23Spliceosome_Homo sapiens_hsa030401.44092894
24RNA transport_Homo sapiens_hsa030131.41787151
25Morphine addiction_Homo sapiens_hsa050321.40506322
26Huntingtons disease_Homo sapiens_hsa050161.31405163
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.28324932
28DNA replication_Homo sapiens_hsa030301.25202592
29Collecting duct acid secretion_Homo sapiens_hsa049661.24021099
30Mismatch repair_Homo sapiens_hsa034301.23479915
31Regulation of autophagy_Homo sapiens_hsa041401.21581212
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19054957
33Alzheimers disease_Homo sapiens_hsa050101.13154207
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12858011
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11861261
36GABAergic synapse_Homo sapiens_hsa047271.11278609
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10683387
38Phototransduction_Homo sapiens_hsa047441.09770612
39Propanoate metabolism_Homo sapiens_hsa006401.07667152
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06737660
41Fatty acid elongation_Homo sapiens_hsa000621.06346692
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05694266
43Steroid biosynthesis_Homo sapiens_hsa001001.05167618
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03238090
45Fatty acid biosynthesis_Homo sapiens_hsa000610.98704857
46Tryptophan metabolism_Homo sapiens_hsa003800.98092676
47Fatty acid metabolism_Homo sapiens_hsa012120.95895227
48Serotonergic synapse_Homo sapiens_hsa047260.95070746
49Purine metabolism_Homo sapiens_hsa002300.89452153
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89257690
51Chemical carcinogenesis_Homo sapiens_hsa052040.86560234
52mRNA surveillance pathway_Homo sapiens_hsa030150.86346428
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84595638
54Olfactory transduction_Homo sapiens_hsa047400.84545554
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84306959
56Rheumatoid arthritis_Homo sapiens_hsa053230.84301473
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83004184
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82249268
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81115613
60Pyrimidine metabolism_Homo sapiens_hsa002400.77855379
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73993090
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73321216
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70609988
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70599204
65Nucleotide excision repair_Homo sapiens_hsa034200.69549476
66Linoleic acid metabolism_Homo sapiens_hsa005910.68574749
67Biosynthesis of amino acids_Homo sapiens_hsa012300.67349220
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66900892
69Metabolic pathways_Homo sapiens_hsa011000.63648641
70Ether lipid metabolism_Homo sapiens_hsa005650.63612820
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.62105282
72Retinol metabolism_Homo sapiens_hsa008300.61162018
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60246087
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59724052
75Systemic lupus erythematosus_Homo sapiens_hsa053220.58619207
76Peroxisome_Homo sapiens_hsa041460.58513137
77Butanoate metabolism_Homo sapiens_hsa006500.56820059
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.56522833
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54556159
80Taste transduction_Homo sapiens_hsa047420.53600271
81Asthma_Homo sapiens_hsa053100.52582986
82Non-homologous end-joining_Homo sapiens_hsa034500.52161792
83Dopaminergic synapse_Homo sapiens_hsa047280.51426034
84Synaptic vesicle cycle_Homo sapiens_hsa047210.51361806
85Fatty acid degradation_Homo sapiens_hsa000710.50500092
86Vitamin digestion and absorption_Homo sapiens_hsa049770.49597947
87Base excision repair_Homo sapiens_hsa034100.48885798
88Pyruvate metabolism_Homo sapiens_hsa006200.48833408
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48250079
90Glutamatergic synapse_Homo sapiens_hsa047240.47894757
91Folate biosynthesis_Homo sapiens_hsa007900.46310866
92Galactose metabolism_Homo sapiens_hsa000520.45551623
93Arginine and proline metabolism_Homo sapiens_hsa003300.45052189
94Cell cycle_Homo sapiens_hsa041100.44248530
95Epstein-Barr virus infection_Homo sapiens_hsa051690.42291800
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41867409
97Alcoholism_Homo sapiens_hsa050340.40273238
98Cardiac muscle contraction_Homo sapiens_hsa042600.38621755
99Primary immunodeficiency_Homo sapiens_hsa053400.37428452
100Mineral absorption_Homo sapiens_hsa049780.36252044

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