ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.21198566
2	chaperone-mediated protein transport (GO:0072321)	8.02236637
3	viral transcription (GO:0019083)	7.71693238
4	translational termination (GO:0006415)	7.33301218
5	ribosomal small subunit assembly (GO:0000028)	6.97092589
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.93641929
7	ATP synthesis coupled proton transport (GO:0015986)	6.93641929
8	maturation of SSU-rRNA (GO:0030490)	6.79797224
9	translational elongation (GO:0006414)	6.42066635
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.36584890
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.34414567
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.27714883
13	cotranslational protein targeting to membrane (GO:0006613)	6.22289310
14	protein targeting to ER (GO:0045047)	6.19408689
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.00165262
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.93087053
17	protein localization to endoplasmic reticulum (GO:0070972)	5.83505400
18	respiratory electron transport chain (GO:0022904)	5.59078026
19	cellular protein complex disassembly (GO:0043624)	5.58750880
20	viral life cycle (GO:0019058)	5.55299697
21	electron transport chain (GO:0022900)	5.47151529
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.43028701
23	NADH dehydrogenase complex assembly (GO:0010257)	5.43028701
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.43028701
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.41938239
26	protein neddylation (GO:0045116)	5.22876379
27	translational initiation (GO:0006413)	5.17805633
28	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.13607384
29	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.05478974
30	protein complex biogenesis (GO:0070271)	4.89937648
31	ribonucleoprotein complex biogenesis (GO:0022613)	4.88158661
32	translation (GO:0006412)	4.78098993
33	GTP biosynthetic process (GO:0006183)	4.77814704
34	protein complex disassembly (GO:0043241)	4.73145972
35	mitochondrial respiratory chain complex assembly (GO:0033108)	4.69693667
36	cellular component biogenesis (GO:0044085)	4.64305592
37	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.55889305
38	ATP biosynthetic process (GO:0006754)	4.48965494
39	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.47923380
40	macromolecular complex disassembly (GO:0032984)	4.44362596
41	pyrimidine nucleotide catabolic process (GO:0006244)	4.41967721
42	ribosomal large subunit biogenesis (GO:0042273)	4.40898746
43	protein targeting to mitochondrion (GO:0006626)	4.34597381
44	pseudouridine synthesis (GO:0001522)	4.31576195
45	UTP biosynthetic process (GO:0006228)	4.31080681
46	DNA deamination (GO:0045006)	4.30450015
47	protein targeting to membrane (GO:0006612)	4.23428864
48	ribonucleoside triphosphate biosynthetic process (GO:0009201)	4.20467828
49	establishment of protein localization to mitochondrion (GO:0072655)	4.00093698
50	UTP metabolic process (GO:0046051)	3.97584289
51	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.94899175
52	guanosine-containing compound biosynthetic process (GO:1901070)	3.93018331
53	CTP biosynthetic process (GO:0006241)	3.89131600
54	CTP metabolic process (GO:0046036)	3.89131600
55	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.85770218
56	protein localization to mitochondrion (GO:0070585)	3.79125295
57	termination of RNA polymerase III transcription (GO:0006386)	3.78743865
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.78743865
59	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.73032025
60	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.72556007
61	hydrogen ion transmembrane transport (GO:1902600)	3.68489939
62	nucleoside triphosphate biosynthetic process (GO:0009142)	3.67061409
63	mRNA catabolic process (GO:0006402)	3.63517523
64	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.62765794
65	substrate-independent telencephalic tangential migration (GO:0021826)	3.62765794
66	behavioral response to nicotine (GO:0035095)	3.62528839
67	ribosome biogenesis (GO:0042254)	3.61654775
68	rRNA processing (GO:0006364)	3.60343623
69	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.60306089
70	ncRNA 3-end processing (GO:0043628)	3.53542114
71	water-soluble vitamin biosynthetic process (GO:0042364)	3.52301271
72	rRNA metabolic process (GO:0016072)	3.46595575
73	intracellular protein transmembrane import (GO:0044743)	3.41365769
74	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.39349515
75	peptidyl-histidine modification (GO:0018202)	3.34149738
76	RNA catabolic process (GO:0006401)	3.24891790
77	protein-cofactor linkage (GO:0018065)	3.24038899
78	iron-sulfur cluster assembly (GO:0016226)	3.22768507
79	metallo-sulfur cluster assembly (GO:0031163)	3.22768507
80	respiratory chain complex IV assembly (GO:0008535)	3.22128178
81	mitochondrial transport (GO:0006839)	3.19396349
82	protein targeting (GO:0006605)	3.17179625
83	oxidative phosphorylation (GO:0006119)	3.16045993
84	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.15221151
85	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	3.14053766
86	purine nucleoside monophosphate biosynthetic process (GO:0009127)	3.14053766
87	proton transport (GO:0015992)	3.11247165
88	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.07028476
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04070560
90	hydrogen transport (GO:0006818)	3.04014652
91	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.03047363
92	proteasome assembly (GO:0043248)	3.01970587
93	establishment of protein localization to membrane (GO:0090150)	2.97388722
94	protein transmembrane transport (GO:0071806)	2.89414237
95	deoxyribonucleotide catabolic process (GO:0009264)	2.87494163
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.87390075
97	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.87390075
98	nucleoside monophosphate biosynthetic process (GO:0009124)	2.83346944
99	cytochrome complex assembly (GO:0017004)	2.81702878
100	establishment of protein localization to organelle (GO:0072594)	2.81585171

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.63367871
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.58313060
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.19114802
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.81205474
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.81143470
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.68218240
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.66742818
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.46068186
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.37424825
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.37088197
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.83898533
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.79957428
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.78591893
14	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.65678431
15	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.63202657
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.58994783
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.55779321
18	EZH2_22144423_ChIP-Seq_EOC_Human	2.49285864
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.48884271
20	TTF2_22483619_ChIP-Seq_HELA_Human	2.26668857
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.19607948
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.15121823
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.12471215
24	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.07768048
25	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.07529801
26	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.01007118
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98806520
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.98797062
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.92401521
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91943005
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.81422898
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71989465
33	DCP1A_22483619_ChIP-Seq_HELA_Human	1.68184969
34	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.66231318
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.62749215
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.60207778
37	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.58650597
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55265548
39	VDR_22108803_ChIP-Seq_LS180_Human	1.50769968
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.43034974
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43013914
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42188343
43	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.39032905
44	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.38692566
45	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.37643718
46	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.34631246
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33340070
48	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32958794
49	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.32429021
50	ZNF263_19887448_ChIP-Seq_K562_Human	1.29737668
51	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.27916729
52	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26681767
53	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.25656748
54	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.23792571
55	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19792170
56	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.19720039
57	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.19253284
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.17104557
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.11456166
60	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.09594727
61	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.08337454
62	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07194618
63	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.04727909
64	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.02991748
65	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02708446
66	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.02570140
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01969829
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00535017
69	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.00456440
70	NCOR_22424771_ChIP-Seq_293T_Human	0.97980033
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97311831
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96237049
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.90952481
74	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.90097120
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89876542
76	CTCF_20526341_ChIP-Seq_ESCs_Human	0.87999566
77	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.87346852
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87308947
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.87154321
80	BCL6_27268052_Chip-Seq_Bcells_Human	0.86434425
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.86117063
82	CIITA_25753668_ChIP-Seq_RAJI_Human	0.85544761
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.85493137
84	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.85008559
85	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.84860437
86	SA1_27219007_Chip-Seq_Bcells_Human	0.84478180
87	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.83998846
88	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.83663842
89	ZNF274_21170338_ChIP-Seq_K562_Hela	0.82968818
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.82935443
91	ERA_21632823_ChIP-Seq_H3396_Human	0.82824721
92	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.82266569
93	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.81220244
94	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.80714306
95	TP53_22573176_ChIP-Seq_HFKS_Human	0.80525929
96	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.80522559
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.80354618
98	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.80252323
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.78943908
100	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.78635362

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.00643423
2	MP0006292_abnormal_olfactory_placode	4.71292408
3	MP0003123_paternal_imprinting	3.62270347
4	MP0002163_abnormal_gland_morphology	3.36468793
5	MP0002160_abnormal_reproductive_system	2.33107574
6	MP0006276_abnormal_autonomic_nervous	2.24169972
7	MP0001348_abnormal_lacrimal_gland	2.17948851
8	MP0002653_abnormal_ependyma_morphology	2.17038692
9	MP0004145_abnormal_muscle_electrophysio	2.16226558
10	MP0001529_abnormal_vocalization	2.10770097
11	MP0008789_abnormal_olfactory_epithelium	2.09020400
12	MP0005646_abnormal_pituitary_gland	2.03360992
13	MP0003186_abnormal_redox_activity	1.96866695
14	MP0000049_abnormal_middle_ear	1.95079222
15	MP0004142_abnormal_muscle_tone	1.94975161
16	MP0003787_abnormal_imprinting	1.88008229
17	MP0005379_endocrine/exocrine_gland_phen	1.87333841
18	MP0004885_abnormal_endolymph	1.81469372
19	MP0006036_abnormal_mitochondrial_physio	1.74541008
20	MP0005394_taste/olfaction_phenotype	1.72961631
21	MP0005499_abnormal_olfactory_system	1.72961631
22	MP0003880_abnormal_central_pattern	1.72907339
23	MP0004858_abnormal_nervous_system	1.72112677
24	MP0005389_reproductive_system_phenotype	1.71463714
25	MP0000678_abnormal_parathyroid_gland	1.70296614
26	MP0004147_increased_porphyrin_level	1.66471314
27	MP0003122_maternal_imprinting	1.60269837
28	MP0003693_abnormal_embryo_hatching	1.59576240
29	MP0003121_genomic_imprinting	1.56884841
30	MP0001188_hyperpigmentation	1.51674681
31	MP0008877_abnormal_DNA_methylation	1.51268856
32	MP0001905_abnormal_dopamine_level	1.44201881
33	MP0002095_abnormal_skin_pigmentation	1.43604561
34	MP0001542_abnormal_bone_strength	1.42393340
35	MP0009046_muscle_twitch	1.29179805
36	MP0002184_abnormal_innervation	1.25260203
37	MP0001293_anophthalmia	1.23870622
38	MP0008875_abnormal_xenobiotic_pharmacok	1.23350567
39	MP0001919_abnormal_reproductive_system	1.23305432
40	MP0002638_abnormal_pupillary_reflex	1.23179134
41	MP0002132_abnormal_respiratory_system	1.23133618
42	MP0003646_muscle_fatigue	1.22710193
43	MP0000955_abnormal_spinal_cord	1.19291645
44	MP0000631_abnormal_neuroendocrine_gland	1.14318998
45	MP0000372_irregular_coat_pigmentation	1.14228400
46	MP0002837_dystrophic_cardiac_calcinosis	1.13769470
47	MP0002277_abnormal_respiratory_mucosa	1.13561139
48	MP0009745_abnormal_behavioral_response	1.08025444
49	MP0003806_abnormal_nucleotide_metabolis	1.07718388
50	MP0002736_abnormal_nociception_after	1.04570647
51	MP0003938_abnormal_ear_development	1.02352806
52	MP0002752_abnormal_somatic_nervous	1.02304104
53	MP0008058_abnormal_DNA_repair	1.01598673
54	MP0002938_white_spotting	1.00978440
55	MP0004133_heterotaxia	0.99484607
56	MP0003942_abnormal_urinary_system	0.98940642
57	MP0001968_abnormal_touch/_nociception	0.98833777
58	MP0009053_abnormal_anal_canal	0.98025335
59	MP0002234_abnormal_pharynx_morphology	0.97806443
60	MP0003937_abnormal_limbs/digits/tail_de	0.97731958
61	MP0006072_abnormal_retinal_apoptosis	0.97683657
62	MP0008932_abnormal_embryonic_tissue	0.95857426
63	MP0004742_abnormal_vestibular_system	0.95259652
64	MP0001440_abnormal_grooming_behavior	0.95234658
65	MP0000778_abnormal_nervous_system	0.93989106
66	MP0005670_abnormal_white_adipose	0.92785162
67	MP0005377_hearing/vestibular/ear_phenot	0.91897710
68	MP0003878_abnormal_ear_physiology	0.91897710
69	MP0001270_distended_abdomen	0.91853516
70	MP0002557_abnormal_social/conspecific_i	0.91258083
71	MP0002272_abnormal_nervous_system	0.91095198
72	MP0003136_yellow_coat_color	0.88012922
73	MP0005187_abnormal_penis_morphology	0.87747443
74	MP0002210_abnormal_sex_determination	0.86786729
75	MP0006035_abnormal_mitochondrial_morpho	0.86337492
76	MP0005195_abnormal_posterior_eye	0.85190331
77	MP0003567_abnormal_fetal_cardiomyocyte	0.85078559
78	MP0005551_abnormal_eye_electrophysiolog	0.83610231
79	MP0001485_abnormal_pinna_reflex	0.82584153
80	MP0002751_abnormal_autonomic_nervous	0.82058697
81	MP0000026_abnormal_inner_ear	0.81701579
82	MP0003119_abnormal_digestive_system	0.80920314
83	MP0002876_abnormal_thyroid_physiology	0.79709904
84	MP0008775_abnormal_heart_ventricle	0.78257688
85	MP0005636_abnormal_mineral_homeostasis	0.77798201
86	MP0003786_premature_aging	0.77705062
87	MP0002233_abnormal_nose_morphology	0.77187431
88	MP0003011_delayed_dark_adaptation	0.76400063
89	MP0010030_abnormal_orbit_morphology	0.73991159
90	MP0001970_abnormal_pain_threshold	0.73722080
91	MP0004957_abnormal_blastocyst_morpholog	0.72222528
92	MP0003755_abnormal_palate_morphology	0.71129259
93	MP0003861_abnormal_nervous_system	0.69738301
94	MP0001984_abnormal_olfaction	0.68600450
95	MP0003635_abnormal_synaptic_transmissio	0.68480569
96	MP0002102_abnormal_ear_morphology	0.68291973
97	MP0000343_altered_response_to	0.67784023
98	MP0002177_abnormal_outer_ear	0.67531910
99	MP0003936_abnormal_reproductive_system	0.67077192
100	MP0002064_seizures	0.66468485

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.23552329
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.81505215
3	Acute encephalopathy (HP:0006846)	5.37085618
4	Mitochondrial inheritance (HP:0001427)	5.30058870
5	Progressive macrocephaly (HP:0004481)	5.05035808
6	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	5.05009997
7	Decreased activity of mitochondrial respiratory chain (HP:0008972)	5.05009997
8	Increased CSF lactate (HP:0002490)	4.86912353
9	Abnormality of cells of the erythroid lineage (HP:0012130)	4.85468908
10	Abnormal number of erythroid precursors (HP:0012131)	4.68996861
11	Reticulocytopenia (HP:0001896)	4.47834210
12	Increased hepatocellular lipid droplets (HP:0006565)	4.45690205
13	Renal Fanconi syndrome (HP:0001994)	4.38532634
14	Increased intramyocellular lipid droplets (HP:0012240)	4.12883778
15	Cerebral edema (HP:0002181)	4.07546010
16	Hepatocellular necrosis (HP:0001404)	4.00827307
17	Macrocytic anemia (HP:0001972)	3.91654070
18	Lipid accumulation in hepatocytes (HP:0006561)	3.89660287
19	3-Methylglutaconic aciduria (HP:0003535)	3.73454701
20	Hepatic necrosis (HP:0002605)	3.66596626
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.45193973
22	Increased muscle lipid content (HP:0009058)	3.44442191
23	Abnormality of renal resorption (HP:0011038)	3.29803806
24	Pallor (HP:0000980)	3.24865976
25	Increased serum lactate (HP:0002151)	3.22392883
26	Lactic acidosis (HP:0003128)	3.22043747
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.12858277
28	Exertional dyspnea (HP:0002875)	3.10078798
29	Exercise intolerance (HP:0003546)	3.03081980
30	Respiratory failure (HP:0002878)	3.02885845
31	Optic disc pallor (HP:0000543)	2.94563799
32	Abnormality of midbrain morphology (HP:0002418)	2.92023922
33	Molar tooth sign on MRI (HP:0002419)	2.92023922
34	Respiratory difficulties (HP:0002880)	2.87987095
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.80900571
36	Microretrognathia (HP:0000308)	2.80571225
37	Leukodystrophy (HP:0002415)	2.67809454
38	Anencephaly (HP:0002323)	2.56656130
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.46632066
40	Myokymia (HP:0002411)	2.46022477
41	Hyperphosphaturia (HP:0003109)	2.43920352
42	Pendular nystagmus (HP:0012043)	2.43105453
43	Hyperglycinemia (HP:0002154)	2.42891808
44	Pancreatic fibrosis (HP:0100732)	2.40664223
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.36223245
46	Abnormal urine phosphate concentration (HP:0012599)	2.33498489
47	Lethargy (HP:0001254)	2.30883378
48	Abnormal hemoglobin (HP:0011902)	2.28803659
49	Glycosuria (HP:0003076)	2.25660302
50	Abnormality of urine glucose concentration (HP:0011016)	2.25660302
51	Hyperalaninemia (HP:0003348)	2.24422195
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24422195
53	Abnormality of alanine metabolism (HP:0010916)	2.24422195
54	Sclerocornea (HP:0000647)	2.22860412
55	Adrenal hypoplasia (HP:0000835)	2.20776564
56	Abnormality of magnesium homeostasis (HP:0004921)	2.19335713
57	Pancreatic cysts (HP:0001737)	2.19179837
58	Testicular atrophy (HP:0000029)	2.17805191
59	Congenital stationary night blindness (HP:0007642)	2.09148963
60	Hyperthyroidism (HP:0000836)	2.04020295
61	Cleft eyelid (HP:0000625)	2.02797054
62	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.02555849
63	Poor suck (HP:0002033)	2.01855898
64	True hermaphroditism (HP:0010459)	2.00022689
65	Occipital encephalocele (HP:0002085)	1.98849098
66	X-linked dominant inheritance (HP:0001423)	1.98500050
67	Double outlet right ventricle (HP:0001719)	1.95373583
68	Congenital malformation of the right heart (HP:0011723)	1.95373583
69	Colon cancer (HP:0003003)	1.92433931
70	Degeneration of anterior horn cells (HP:0002398)	1.91954130
71	Abnormality of the anterior horn cell (HP:0006802)	1.91954130
72	Absent thumb (HP:0009777)	1.88723013
73	Abnormal number of incisors (HP:0011064)	1.88231011
74	Cerebral hypomyelination (HP:0006808)	1.85108493
75	Generalized aminoaciduria (HP:0002909)	1.81624873
76	Depressed nasal ridge (HP:0000457)	1.81463827
77	Type 2 muscle fiber atrophy (HP:0003554)	1.81366499
78	Metaphyseal dysplasia (HP:0100255)	1.81014233
79	Muscle fiber atrophy (HP:0100295)	1.80310292
80	Rectal prolapse (HP:0002035)	1.78259317
81	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.77538336
82	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.77538336
83	Neoplasm of head and neck (HP:0012288)	1.72114859
84	Esophageal neoplasm (HP:0100751)	1.72114859
85	Partial duplication of thumb phalanx (HP:0009944)	1.70997846
86	Triphalangeal thumb (HP:0001199)	1.70162054
87	Truncus arteriosus (HP:0001660)	1.69693850
88	Blindness (HP:0000618)	1.69128570
89	Absent/shortened dynein arms (HP:0200106)	1.69123657
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.69123657
91	CNS demyelination (HP:0007305)	1.68756335
92	Hypomagnesemia (HP:0002917)	1.68140859
93	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.66638624
94	Progressive microcephaly (HP:0000253)	1.65984505
95	Asplenia (HP:0001746)	1.65702237
96	Medial flaring of the eyebrow (HP:0010747)	1.65338633
97	Postaxial foot polydactyly (HP:0001830)	1.64326202
98	Osteomalacia (HP:0002749)	1.63417838
99	Concave nail (HP:0001598)	1.63223945
100	Increased serum pyruvate (HP:0003542)	1.61480101

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	7.07070677
2	BCKDK	4.25857960
3	PDK2	3.76284818
4	WNK4	3.40318007
5	ABL2	2.18781967
6	DYRK2	2.13510943
7	ARAF	2.11502989
8	BUB1	1.99636871
9	MAP3K9	1.90805724
10	NEK1	1.88685903
11	GRK1	1.85822090
12	LRRK2	1.82985505
13	EIF2AK1	1.75231885
14	ADRBK2	1.60425352
15	TIE1	1.55351075
16	PIM2	1.50901575
17	DYRK3	1.48376113
18	STK39	1.38724022
19	ZAK	1.33723116
20	BRAF	1.31435355
21	STK16	1.30302042
22	PINK1	1.29404325
23	CAMK1D	1.26984207
24	NUAK1	1.25080585
25	AURKA	1.23742706
26	MAP3K11	1.20148160
27	CDC7	1.18200799
28	EPHA4	1.17358021
29	PIK3CA	1.15381486
30	ILK	1.13296954
31	PLK4	1.13009883
32	MAP4K2	1.11021897
33	LIMK1	1.07680604
34	TLK1	1.04263718
35	VRK2	0.99624909
36	PRKCG	0.98566637
37	NME1	0.97665138
38	WNK3	0.96004621
39	CSNK2A2	0.93043479
40	CAMKK2	0.89604964
41	MINK1	0.83775646
42	RPS6KA5	0.83733413
43	NTRK2	0.83643745
44	CSNK2A1	0.82964491
45	BRSK1	0.82747679
46	CAMK1	0.80671321
47	AURKB	0.79886980
48	PLK1	0.78654606
49	MAP2K7	0.78314326
50	CHEK2	0.75196517
51	CSNK1G2	0.74233460
52	STK4	0.73173193
53	PRKCI	0.67961585
54	PAK1	0.67502582
55	NTRK3	0.65461920
56	CSNK1G3	0.64122293
57	CAMK1G	0.63895686
58	PRKACA	0.63541529
59	ADRBK1	0.62364995
60	INSRR	0.62215712
61	RPS6KA4	0.61616022
62	OBSCN	0.59775773
63	STK11	0.58843029
64	PHKG1	0.58623970
65	PHKG2	0.58623970
66	PBK	0.58549819
67	CSNK1E	0.58420452
68	BMPR1B	0.57880633
69	CASK	0.56684449
70	ATR	0.54384473
71	MAP2K2	0.53384821
72	CDK8	0.51653160
73	SRPK1	0.51436768
74	MAPK13	0.51436137
75	PLK3	0.50841540
76	CHEK1	0.50781498
77	RPS6KA2	0.47566523
78	DMPK	0.46720535
79	RPS6KA6	0.46511084
80	CDK14	0.44936972
81	PRKCH	0.41184698
82	CSNK1A1	0.40627058
83	MAP2K6	0.40099616
84	VRK1	0.38892862
85	CAMKK1	0.38182520
86	CAMK2A	0.37639014
87	CDK11A	0.36406614
88	GRK5	0.36175044
89	CDK15	0.36032750
90	WNK1	0.35714822
91	CSNK1G1	0.35641444
92	EPHB2	0.35002656
93	PRKCQ	0.34765360
94	PRKCA	0.33974815
95	RPS6KC1	0.33503397
96	RPS6KL1	0.33503397
97	CAMK4	0.33440208
98	MAP3K4	0.31765477
99	IKBKB	0.31659270
100	DYRK1B	0.31612147

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.77051645
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.30307002
3	Parkinsons disease_Homo sapiens_hsa05012	4.60868539
4	Huntingtons disease_Homo sapiens_hsa05016	3.41775143
5	RNA polymerase_Homo sapiens_hsa03020	3.21798965
6	Alzheimers disease_Homo sapiens_hsa05010	3.20028427
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	3.01681793
8	Sulfur relay system_Homo sapiens_hsa04122	2.56922345
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.55733743
10	Proteasome_Homo sapiens_hsa03050	2.26543896
11	One carbon pool by folate_Homo sapiens_hsa00670	2.12679569
12	Pyrimidine metabolism_Homo sapiens_hsa00240	2.09601808
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91266192
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79712887
15	DNA replication_Homo sapiens_hsa03030	1.76235924
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74400140
17	Homologous recombination_Homo sapiens_hsa03440	1.68130778
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.66834854
19	Protein export_Homo sapiens_hsa03060	1.64097418
20	Folate biosynthesis_Homo sapiens_hsa00790	1.62957014
21	Spliceosome_Homo sapiens_hsa03040	1.33786028
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30922287
23	Base excision repair_Homo sapiens_hsa03410	1.28469933
24	Purine metabolism_Homo sapiens_hsa00230	1.22752787
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.20663677
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.15275712
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15069401
28	Mismatch repair_Homo sapiens_hsa03430	1.13555997
29	RNA degradation_Homo sapiens_hsa03018	1.11412705
30	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06125613
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.03867854
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.02504198
33	Nucleotide excision repair_Homo sapiens_hsa03420	0.99996130
34	Metabolic pathways_Homo sapiens_hsa01100	0.97785735
35	Pyruvate metabolism_Homo sapiens_hsa00620	0.94804928
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89375302
37	RNA transport_Homo sapiens_hsa03013	0.88576253
38	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84505331
39	Sulfur metabolism_Homo sapiens_hsa00920	0.83590039
40	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.79996715
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79044332
42	Propanoate metabolism_Homo sapiens_hsa00640	0.75124033
43	Basal transcription factors_Homo sapiens_hsa03022	0.72041006
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70284574
45	Phototransduction_Homo sapiens_hsa04744	0.67165936
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63380804
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.63147686
48	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.62314862
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.61080558
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.58584823
51	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58459854
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58339380
53	Peroxisome_Homo sapiens_hsa04146	0.58199294
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56957256
55	Fatty acid elongation_Homo sapiens_hsa00062	0.53815406
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53126833
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.52578849
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51412564
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.50422459
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50211214
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.47375552
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40079406
63	Nicotine addiction_Homo sapiens_hsa05033	0.38957712
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37324209
65	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.36817975
66	Carbon metabolism_Homo sapiens_hsa01200	0.35594900
67	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.35456708
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.35189529
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35133848
70	Caffeine metabolism_Homo sapiens_hsa00232	0.34910222
71	Glutathione metabolism_Homo sapiens_hsa00480	0.33849200
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.31658379
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29630281
74	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29290111
75	Butanoate metabolism_Homo sapiens_hsa00650	0.28030279
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27413427
77	Morphine addiction_Homo sapiens_hsa05032	0.26788711
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.26099337
79	p53 signaling pathway_Homo sapiens_hsa04115	0.25237621
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24478679
81	Olfactory transduction_Homo sapiens_hsa04740	0.24464433
82	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.23653599
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22082345
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.21881562
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.21838765
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.20642849
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20143012
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.19302697
89	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.19091398
90	Cell cycle_Homo sapiens_hsa04110	0.17812685
91	Retinol metabolism_Homo sapiens_hsa00830	0.17525597
92	Fatty acid degradation_Homo sapiens_hsa00071	0.15333763
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.13741484
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.13158653
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.11296409
96	Galactose metabolism_Homo sapiens_hsa00052	0.11216001
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.10795209
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.10488305
99	Melanoma_Homo sapiens_hsa05218	0.05753630
100	GABAergic synapse_Homo sapiens_hsa04727	0.04928843

CCT5P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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