CCT6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.17331663
2establishment of integrated proviral latency (GO:0075713)5.16369157
3nuclear pore organization (GO:0006999)4.71471977
4DNA strand elongation involved in DNA replication (GO:0006271)4.66617157
5DNA unwinding involved in DNA replication (GO:0006268)4.63648539
6ribosome assembly (GO:0042255)4.62525679
7DNA strand elongation (GO:0022616)4.50507333
8mitotic metaphase plate congression (GO:0007080)4.47773699
9formation of translation preinitiation complex (GO:0001731)4.31084581
10telomere maintenance via semi-conservative replication (GO:0032201)4.25076268
11mitotic sister chromatid segregation (GO:0000070)4.14215557
12protein localization to kinetochore (GO:0034501)4.06618841
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.05205640
14mitotic chromosome condensation (GO:0007076)4.03862206
15establishment of viral latency (GO:0019043)4.03638416
16CENP-A containing nucleosome assembly (GO:0034080)4.01922430
17DNA replication checkpoint (GO:0000076)4.01891394
18chromatin remodeling at centromere (GO:0031055)3.96170880
19proteasome assembly (GO:0043248)3.92501520
20sister chromatid segregation (GO:0000819)3.89880449
21IMP biosynthetic process (GO:0006188)3.89346414
22mitotic sister chromatid cohesion (GO:0007064)3.89274341
23metaphase plate congression (GO:0051310)3.88078704
24protein localization to chromosome, centromeric region (GO:0071459)3.87094536
25pore complex assembly (GO:0046931)3.83248482
26mitotic nuclear envelope disassembly (GO:0007077)3.73720747
27purine nucleobase biosynthetic process (GO:0009113)3.66037756
28telomere maintenance via recombination (GO:0000722)3.63232307
29DNA replication initiation (GO:0006270)3.61229871
30regulation of translational fidelity (GO:0006450)3.60271404
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59952395
32mitotic recombination (GO:0006312)3.56774549
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54565936
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.54405137
35nucleobase biosynthetic process (GO:0046112)3.49763914
36nuclear envelope disassembly (GO:0051081)3.49758241
37membrane disassembly (GO:0030397)3.49758241
38non-recombinational repair (GO:0000726)3.48669862
39double-strand break repair via nonhomologous end joining (GO:0006303)3.48669862
40IMP metabolic process (GO:0046040)3.43757706
41tRNA aminoacylation for protein translation (GO:0006418)3.43322459
42DNA ligation (GO:0006266)3.40869749
43DNA replication-independent nucleosome assembly (GO:0006336)3.39576946
44DNA replication-independent nucleosome organization (GO:0034724)3.39576946
45ribosome biogenesis (GO:0042254)3.37209857
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.36963499
47ribosomal large subunit biogenesis (GO:0042273)3.35900191
48negative regulation of ligase activity (GO:0051352)3.35753515
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35753515
50amino acid activation (GO:0043038)3.35139879
51tRNA aminoacylation (GO:0043039)3.35139879
52protein complex localization (GO:0031503)3.31443723
53histone exchange (GO:0043486)3.30570018
54establishment of chromosome localization (GO:0051303)3.29007047
55folic acid-containing compound biosynthetic process (GO:0009396)3.28758530
56spindle checkpoint (GO:0031577)3.26312585
57nucleobase-containing small molecule interconversion (GO:0015949)3.25590711
58regulation of mitochondrial translation (GO:0070129)3.24171279
59regulation of chromosome segregation (GO:0051983)3.23745277
60mitotic spindle checkpoint (GO:0071174)3.21542032
61regulation of centriole replication (GO:0046599)3.20263959
62regulation of mitotic spindle organization (GO:0060236)3.19740786
63negative regulation of chromosome segregation (GO:0051985)3.18627831
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.14505020
65negative regulation of sister chromatid segregation (GO:0033046)3.14505020
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14505020
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14505020
68negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14505020
69ribonucleoprotein complex biogenesis (GO:0022613)3.09893523
70telomere maintenance via telomere lengthening (GO:0010833)3.09834201
71DNA topological change (GO:0006265)3.07148914
72regulation of spindle organization (GO:0090224)3.06728882
73cellular protein complex localization (GO:0034629)3.06648918
74L-serine metabolic process (GO:0006563)3.06646765
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.06280488
76mitotic spindle assembly checkpoint (GO:0007094)3.06208675
77DNA replication-dependent nucleosome organization (GO:0034723)3.05437521
78DNA replication-dependent nucleosome assembly (GO:0006335)3.05437521
79spliceosomal snRNP assembly (GO:0000387)3.04456671
80kinetochore organization (GO:0051383)3.03500763
81spindle assembly checkpoint (GO:0071173)3.03025789
82positive regulation of chromosome segregation (GO:0051984)3.03025203
83cell cycle G1/S phase transition (GO:0044843)2.99602695
84G1/S transition of mitotic cell cycle (GO:0000082)2.99602695
85regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98441801
86regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98441801
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95597768
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92921944
89DNA duplex unwinding (GO:0032508)2.92831607
90DNA damage response, detection of DNA damage (GO:0042769)2.91806434
91regulation of centrosome cycle (GO:0046605)2.88253435
92ATP-dependent chromatin remodeling (GO:0043044)2.88190599
93regulation of mitotic sister chromatid separation (GO:0010965)2.87295246
94regulation of mitotic sister chromatid segregation (GO:0033047)2.87295246
95regulation of sister chromatid segregation (GO:0033045)2.87295246
96regulation of ubiquitin-protein transferase activity (GO:0051438)2.86476709
97DNA geometric change (GO:0032392)2.85646607
98rRNA processing (GO:0006364)2.85579544
99regulation of translational termination (GO:0006449)2.84644119
100chromosome segregation (GO:0007059)2.83945836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.39801382
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.46172010
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.15770223
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05994177
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96965633
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53668614
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.46087881
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21590425
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.07794655
10* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04707109
11AR_21909140_ChIP-Seq_LNCAP_Human3.02048040
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98432317
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93559685
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86997614
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85052659
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.84499942
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.61893799
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.61348204
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58854928
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57102032
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.46006548
22DCP1A_22483619_ChIP-Seq_HELA_Human2.38729412
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.28024234
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26550654
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.25483015
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24100598
27* XRN2_22483619_ChIP-Seq_HELA_Human2.22354003
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18755841
29ELK1_19687146_ChIP-ChIP_HELA_Human2.18554987
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14906528
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11010973
32* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.09465787
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02922430
34TTF2_22483619_ChIP-Seq_HELA_Human2.02072368
35* POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.01999558
36GABP_19822575_ChIP-Seq_HepG2_Human1.91187873
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87101629
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80871168
39FOXP3_21729870_ChIP-Seq_TREG_Human1.80608283
40VDR_23849224_ChIP-Seq_CD4+_Human1.76756681
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74673190
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74530675
43* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69553620
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66831636
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62980482
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62957307
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56964058
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52218378
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42901700
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41869836
51KDM5A_27292631_Chip-Seq_BREAST_Human1.41551817
52* SRF_21415370_ChIP-Seq_HL-1_Mouse1.34094600
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.33626970
54* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33493899
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31037746
56ZNF263_19887448_ChIP-Seq_K562_Human1.31025236
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30901643
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29809738
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29553061
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.29118743
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28670036
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22371077
63* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19763529
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19305720
65SOX17_20123909_ChIP-Seq_XEN_Mouse1.17796768
66* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17427723
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17386818
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09681134
69TFEB_21752829_ChIP-Seq_HELA_Human1.07158098
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.06567863
71MYC_18940864_ChIP-ChIP_HL60_Human1.06424933
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06243447
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03506449
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02899312
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01773266
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01550961
77TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00486303
78SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99861178
79* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98439647
80NANOG_16153702_ChIP-ChIP_HESCs_Human0.95730203
81* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93196037
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92884212
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92347232
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91599506
85CHD1_26751641_Chip-Seq_LNCaP_Human0.91581808
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89529459
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87667173
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87499023
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85835779
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85590918
91* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83064842
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.82880793
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82392242
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80405893
95CIITA_25753668_ChIP-Seq_RAJI_Human0.79884979
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79617200
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.78682141
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78622404
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.78614000
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76454436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.82550949
2MP0003693_abnormal_embryo_hatching4.76295346
3MP0004957_abnormal_blastocyst_morpholog4.48209553
4MP0003111_abnormal_nucleus_morphology4.20370406
5MP0008058_abnormal_DNA_repair3.80682023
6MP0003077_abnormal_cell_cycle3.62217245
7MP0008057_abnormal_DNA_replication3.28333999
8MP0008932_abnormal_embryonic_tissue3.16541093
9MP0008007_abnormal_cellular_replicative2.90653683
10MP0001730_embryonic_growth_arrest2.45262013
11MP0003941_abnormal_skin_development2.41003013
12MP0009697_abnormal_copulation2.37298390
13MP0010352_gastrointestinal_tract_polyps2.13003290
14MP0000350_abnormal_cell_proliferation2.12592694
15MP0003806_abnormal_nucleotide_metabolis1.89208069
16MP0003718_maternal_effect1.88996105
17MP0002877_abnormal_melanocyte_morpholog1.84310536
18MP0001672_abnormal_embryogenesis/_devel1.83706288
19MP0005380_embryogenesis_phenotype1.83706288
20MP0001697_abnormal_embryo_size1.81950835
21MP0003786_premature_aging1.80713136
22MP0010234_abnormal_vibrissa_follicle1.71661794
23MP0002080_prenatal_lethality1.68092790
24MP0002084_abnormal_developmental_patter1.62819443
25MP0003984_embryonic_growth_retardation1.59787806
26MP0002085_abnormal_embryonic_tissue1.58375375
27MP0003890_abnormal_embryonic-extraembry1.57976796
28MP0002088_abnormal_embryonic_growth/wei1.53358781
29MP0006035_abnormal_mitochondrial_morpho1.52013855
30MP0009672_abnormal_birth_weight1.51652383
31MP0010307_abnormal_tumor_latency1.46174166
32MP0000537_abnormal_urethra_morphology1.45067779
33MP0010030_abnormal_orbit_morphology1.40332350
34MP0003937_abnormal_limbs/digits/tail_de1.37696054
35MP0000358_abnormal_cell_content/1.35243175
36MP0004197_abnormal_fetal_growth/weight/1.32328757
37MP0000313_abnormal_cell_death1.31512155
38MP0004233_abnormal_muscle_weight1.28107096
39MP0003186_abnormal_redox_activity1.26848227
40MP0002086_abnormal_extraembryonic_tissu1.26308070
41MP0005501_abnormal_skin_physiology1.25184485
42MP0003315_abnormal_perineum_morphology1.24250584
43MP0003123_paternal_imprinting1.22785405
44MP0002697_abnormal_eye_size1.22453055
45MP0001293_anophthalmia1.22426531
46MP0002796_impaired_skin_barrier1.19228656
47MP0003567_abnormal_fetal_cardiomyocyte1.16497012
48MP0000579_abnormal_nail_morphology1.12496829
49MP0003221_abnormal_cardiomyocyte_apopto1.05992088
50MP0002210_abnormal_sex_determination1.00597516
51MP0008877_abnormal_DNA_methylation0.99617663
52MP0001529_abnormal_vocalization0.98322806
53MP0002938_white_spotting0.98051220
54MP0002111_abnormal_tail_morphology0.97154007
55MP0006036_abnormal_mitochondrial_physio0.97104496
56MP0001661_extended_life_span0.96580462
57MP0001286_abnormal_eye_development0.94960509
58MP0004185_abnormal_adipocyte_glucose0.93209498
59MP0009703_decreased_birth_body0.92941860
60MP0000762_abnormal_tongue_morphology0.90649001
61MP0005623_abnormal_meninges_morphology0.89466717
62MP0003385_abnormal_body_wall0.88983634
63MP0003950_abnormal_plasma_membrane0.88509173
64MP0000647_abnormal_sebaceous_gland0.87181672
65MP0002233_abnormal_nose_morphology0.86884259
66MP0002396_abnormal_hematopoietic_system0.85599603
67MP0001929_abnormal_gametogenesis0.85559589
68MP0000490_abnormal_crypts_of0.85502492
69MP0005384_cellular_phenotype0.84690507
70MP0001145_abnormal_male_reproductive0.81875808
71MP0002060_abnormal_skin_morphology0.81691491
72MP0002092_abnormal_eye_morphology0.81505622
73MP0005408_hypopigmentation0.81302214
74MP0006292_abnormal_olfactory_placode0.80013377
75MP0003119_abnormal_digestive_system0.79626439
76MP0003566_abnormal_cell_adhesion0.79596665
77MP0001188_hyperpigmentation0.79590318
78MP0002019_abnormal_tumor_incidence0.77796145
79MP0003755_abnormal_palate_morphology0.77287156
80MP0004272_abnormal_basement_membrane0.75975390
81MP0003705_abnormal_hypodermis_morpholog0.74866991
82MP0001727_abnormal_embryo_implantation0.74566635
83MP0002234_abnormal_pharynx_morphology0.73083681
84MP0000627_abnormal_mammary_gland0.70958243
85MP0000653_abnormal_sex_gland0.70836341
86MP0001881_abnormal_mammary_gland0.70550911
87MP0005621_abnormal_cell_physiology0.70313773
88MP0003861_abnormal_nervous_system0.69823023
89MP0002160_abnormal_reproductive_system0.69574490
90MP0009053_abnormal_anal_canal0.67304622
91MP0000428_abnormal_craniofacial_morphol0.67131657
92MP0003935_abnormal_craniofacial_develop0.67090726
93MP0004782_abnormal_surfactant_physiolog0.66818001
94MP0003943_abnormal_hepatobiliary_system0.66792306
95MP0009379_abnormal_foot_pigmentation0.65836167
96MP0001346_abnormal_lacrimal_gland0.65189080
97MP0005076_abnormal_cell_differentiation0.64325826
98MP0008789_abnormal_olfactory_epithelium0.64261197
99MP0003115_abnormal_respiratory_system0.63274268
100MP0001216_abnormal_epidermal_layer0.61860244

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.49105626
2Chromsome breakage (HP:0040012)4.32883714
3Abnormality of glycolysis (HP:0004366)3.60095062
4Microvesicular hepatic steatosis (HP:0001414)3.47069846
5Increased serum pyruvate (HP:0003542)3.42245641
6Abnormality of the preputium (HP:0100587)3.14040156
7Multiple enchondromatosis (HP:0005701)3.10114368
8Increased nuchal translucency (HP:0010880)3.08499046
9Cortical dysplasia (HP:0002539)2.99058233
10Birth length less than 3rd percentile (HP:0003561)2.97190559
11Meckel diverticulum (HP:0002245)2.94359591
12Abnormality of chromosome stability (HP:0003220)2.92171024
13Abnormality of the ileum (HP:0001549)2.74878909
14Ependymoma (HP:0002888)2.66035891
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.61352765
16Abnormal lung lobation (HP:0002101)2.60830264
17Reticulocytopenia (HP:0001896)2.59525901
18Selective tooth agenesis (HP:0001592)2.58085344
19Small intestinal stenosis (HP:0012848)2.53988042
20Duodenal stenosis (HP:0100867)2.53988042
21Nephroblastoma (Wilms tumor) (HP:0002667)2.47134782
22Embryonal renal neoplasm (HP:0011794)2.38818625
23Abnormality of methionine metabolism (HP:0010901)2.36431641
24Proximal placement of thumb (HP:0009623)2.34258321
25Deviation of the thumb (HP:0009603)2.30966981
26Progressive muscle weakness (HP:0003323)2.27880297
27Myelodysplasia (HP:0002863)2.26932377
28Colon cancer (HP:0003003)2.23438513
29Rhabdomyosarcoma (HP:0002859)2.22759106
30Abnormality of the anterior horn cell (HP:0006802)2.22586460
31Degeneration of anterior horn cells (HP:0002398)2.22586460
32Medulloblastoma (HP:0002885)2.22391914
33Increased hepatocellular lipid droplets (HP:0006565)2.19913968
34Spastic diplegia (HP:0001264)2.18869707
35Horseshoe kidney (HP:0000085)2.17069610
36Abnormality of the duodenum (HP:0002246)2.14533813
37Postnatal microcephaly (HP:0005484)2.14202241
38Abnormality of the umbilical cord (HP:0010881)2.14135258
39Abnormality of the carotid arteries (HP:0005344)2.13572610
40Secondary amenorrhea (HP:0000869)2.12311353
41Progressive external ophthalmoplegia (HP:0000590)2.11408433
42Absent radius (HP:0003974)2.09335167
43Volvulus (HP:0002580)2.08488441
44Shoulder girdle muscle weakness (HP:0003547)2.07447680
45Abnormality of the labia minora (HP:0012880)2.04615651
46Cerebral hypomyelination (HP:0006808)2.02126854
47Facial cleft (HP:0002006)2.01914016
48Acute encephalopathy (HP:0006846)2.00272923
49Type I transferrin isoform profile (HP:0003642)1.98673004
50Abnormalities of placenta or umbilical cord (HP:0001194)1.97254952
51Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96011104
52Choanal atresia (HP:0000453)1.95128927
53Aplasia involving forearm bones (HP:0009822)1.94903191
54Absent forearm bone (HP:0003953)1.94903191
55Abnormality of the astrocytes (HP:0100707)1.93926872
56Astrocytoma (HP:0009592)1.93926872
57Increased serum lactate (HP:0002151)1.93740859
58Abnormal mitochondria in muscle tissue (HP:0008316)1.92749042
59Trismus (HP:0000211)1.92373745
60Glioma (HP:0009733)1.92123312
61Acute necrotizing encephalopathy (HP:0006965)1.92018413
62Abnormal umbilical cord blood vessels (HP:0011403)1.91154951
63Single umbilical artery (HP:0001195)1.91154951
64Abnormality of the fetal cardiovascular system (HP:0010948)1.91154951
65Lipid accumulation in hepatocytes (HP:0006561)1.90053484
66Reduced antithrombin III activity (HP:0001976)1.89707356
67Rough bone trabeculation (HP:0100670)1.88998126
68Cerebral edema (HP:0002181)1.88430952
69Neoplasm of the colon (HP:0100273)1.86014197
70Sparse eyelashes (HP:0000653)1.85654921
71Microglossia (HP:0000171)1.84470792
72Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83004889
73Increased CSF lactate (HP:0002490)1.81813267
74Gout (HP:0001997)1.80527936
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80382647
76Abnormality of alanine metabolism (HP:0010916)1.80382647
77Hyperalaninemia (HP:0003348)1.80382647
78Macrocytic anemia (HP:0001972)1.77939278
79Sloping forehead (HP:0000340)1.77736460
80Premature ovarian failure (HP:0008209)1.76107592
81Overriding aorta (HP:0002623)1.76055847
82Cafe-au-lait spot (HP:0000957)1.76031636
83Triphalangeal thumb (HP:0001199)1.75609594
84Abnormality of serum amino acid levels (HP:0003112)1.72600509
85Insomnia (HP:0100785)1.68537616
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67727169
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67727169
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66558021
89Abnormal protein N-linked glycosylation (HP:0012347)1.66558021
90Abnormal protein glycosylation (HP:0012346)1.66558021
91Abnormal glycosylation (HP:0012345)1.66558021
92Upper limb muscle weakness (HP:0003484)1.66553494
93Squamous cell carcinoma (HP:0002860)1.66286018
94Megaloblastic anemia (HP:0001889)1.65475602
95Missing ribs (HP:0000921)1.64855218
96Overlapping toe (HP:0001845)1.64040557
97Insidious onset (HP:0003587)1.61030472
98Termporal pattern (HP:0011008)1.61030472
99Abnormality of placental membranes (HP:0011409)1.60572422
100Amniotic constriction ring (HP:0009775)1.60572422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.56352722
2TSSK63.70966031
3PBK3.57648493
4NEK13.39507451
5SRPK13.37566128
6CDC73.33411876
7TTK3.23938675
8EIF2AK13.16758542
9WEE12.36225633
10VRK22.35441891
11EIF2AK32.35329463
12PLK42.10990253
13NME22.10955166
14MST42.06178127
15PLK31.97648173
16MKNK11.92108985
17SCYL21.87973120
18TRIM281.83155622
19MST1R1.79685968
20BRSK21.66945399
21MKNK21.63597992
22PLK11.63419043
23TAF11.58589701
24ERBB41.57039685
25BRSK11.42928711
26SMG11.42015820
27PAK41.33386432
28CHEK21.32264516
29ZAK1.30334597
30AURKB1.30213190
31PDK21.26517232
32STK161.26488213
33ATR1.21740962
34PNCK1.16865344
35CDK71.12454992
36NEK21.11584265
37NME11.09544849
38VRK11.08754882
39CHEK11.07090420
40BCR1.06426327
41MET1.00863539
42RPS6KB21.00627096
43CDK80.98040983
44EIF2AK20.97508367
45PASK0.96367359
46EPHA20.96356102
47ALK0.89399226
48AURKA0.87508853
49LATS20.84876882
50MAP3K80.84448702
51CCNB10.80136474
52RPS6KA40.79430913
53ATM0.77023109
54IRAK30.75766949
55ERBB30.74516131
56BRAF0.68357186
57MAP3K100.65915658
58CLK10.64839277
59CDK60.64528676
60CDK120.63447835
61STK40.60528559
62CDK40.60100314
63CDK10.59610247
64MAP3K120.59534755
65CSNK2A20.58529731
66CSNK1G30.57024933
67NUAK10.56811489
68STK100.56346880
69STK30.55998447
70CDK20.55020126
71CSNK1E0.54887348
72CSNK1G10.54244817
73LATS10.51987050
74BRD40.51513268
75CSNK1A1L0.51435894
76FGFR10.51376100
77EEF2K0.49971349
78CSNK2A10.49194612
79AKT20.47430637
80DAPK10.47307201
81SIK30.45493672
82STK38L0.44208119
83PRKCI0.44097971
84LIMK10.43547461
85CDK180.42685561
86CDK90.41932962
87CDK140.39409868
88PTK20.38471406
89CDK11A0.37536812
90PRKDC0.37480304
91PLK20.36596972
92CDK150.36411667
93DYRK30.35969172
94MAPKAPK50.34972287
95CSNK1G20.34768455
96PAK20.31828078
97TESK10.31319556
98MELK0.31121177
99KSR10.30355146
100PAK10.29157190

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29976526
2Proteasome_Homo sapiens_hsa030503.83033588
3Mismatch repair_Homo sapiens_hsa034303.75584400
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36992681
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.26322661
6Non-homologous end-joining_Homo sapiens_hsa034503.00173115
7RNA transport_Homo sapiens_hsa030132.69737710
8Spliceosome_Homo sapiens_hsa030402.68694081
9Base excision repair_Homo sapiens_hsa034102.63880020
10Cell cycle_Homo sapiens_hsa041102.44415465
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.40343447
12Nucleotide excision repair_Homo sapiens_hsa034202.38545690
13Homologous recombination_Homo sapiens_hsa034402.32453815
14One carbon pool by folate_Homo sapiens_hsa006702.18509262
15RNA polymerase_Homo sapiens_hsa030202.12038876
16Ribosome_Homo sapiens_hsa030102.10276436
17Fanconi anemia pathway_Homo sapiens_hsa034601.87109469
18Protein export_Homo sapiens_hsa030601.82025265
19Pyrimidine metabolism_Homo sapiens_hsa002401.81336191
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80670617
21Biosynthesis of amino acids_Homo sapiens_hsa012301.76598266
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.72998117
23Pyruvate metabolism_Homo sapiens_hsa006201.57932063
24mRNA surveillance pathway_Homo sapiens_hsa030151.56687770
25RNA degradation_Homo sapiens_hsa030181.52937549
26Basal transcription factors_Homo sapiens_hsa030221.51628961
27Carbon metabolism_Homo sapiens_hsa012001.48088611
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45815553
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37405566
30Vitamin B6 metabolism_Homo sapiens_hsa007501.31526635
31Selenocompound metabolism_Homo sapiens_hsa004501.21821620
32Steroid biosynthesis_Homo sapiens_hsa001001.17599086
33Fatty acid elongation_Homo sapiens_hsa000621.15472046
34Folate biosynthesis_Homo sapiens_hsa007901.11213884
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10802362
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08493859
37Purine metabolism_Homo sapiens_hsa002301.08079868
38Propanoate metabolism_Homo sapiens_hsa006401.06377367
39Parkinsons disease_Homo sapiens_hsa050121.05842395
40Pentose phosphate pathway_Homo sapiens_hsa000301.05651855
41Oocyte meiosis_Homo sapiens_hsa041140.98547407
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98310597
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97104700
44p53 signaling pathway_Homo sapiens_hsa041150.96621537
45Oxidative phosphorylation_Homo sapiens_hsa001900.95278989
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94348617
47Huntingtons disease_Homo sapiens_hsa050160.93137234
48Glutathione metabolism_Homo sapiens_hsa004800.85456717
49N-Glycan biosynthesis_Homo sapiens_hsa005100.84062727
50Sulfur relay system_Homo sapiens_hsa041220.83095532
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81882696
52Thyroid cancer_Homo sapiens_hsa052160.78018317
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75820691
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72489753
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62483749
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.61064886
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60427944
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59853922
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59374382
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55059050
61Epstein-Barr virus infection_Homo sapiens_hsa051690.53414459
62Sulfur metabolism_Homo sapiens_hsa009200.50938179
63Hippo signaling pathway_Homo sapiens_hsa043900.50881947
64Alzheimers disease_Homo sapiens_hsa050100.49892657
65Fatty acid metabolism_Homo sapiens_hsa012120.49751920
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49652912
67Metabolic pathways_Homo sapiens_hsa011000.49396337
68Galactose metabolism_Homo sapiens_hsa000520.49108440
69Fructose and mannose metabolism_Homo sapiens_hsa000510.48437278
70Arginine and proline metabolism_Homo sapiens_hsa003300.47943286
71Adherens junction_Homo sapiens_hsa045200.47915685
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45585085
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.44841838
74Lysine degradation_Homo sapiens_hsa003100.43033785
75TGF-beta signaling pathway_Homo sapiens_hsa043500.39981209
76Viral carcinogenesis_Homo sapiens_hsa052030.39197805
77Vibrio cholerae infection_Homo sapiens_hsa051100.35276391
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35245945
79Arginine biosynthesis_Homo sapiens_hsa002200.35036630
80MicroRNAs in cancer_Homo sapiens_hsa052060.34191082
81Bladder cancer_Homo sapiens_hsa052190.32501134
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30043389
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27216645
84Small cell lung cancer_Homo sapiens_hsa052220.27113275
85Wnt signaling pathway_Homo sapiens_hsa043100.26431776
86Tight junction_Homo sapiens_hsa045300.25241573
87Colorectal cancer_Homo sapiens_hsa052100.24422289
88Basal cell carcinoma_Homo sapiens_hsa052170.23587981
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23134161
90Alcoholism_Homo sapiens_hsa050340.22587017
91beta-Alanine metabolism_Homo sapiens_hsa004100.20559325
92Shigellosis_Homo sapiens_hsa051310.19615917
93Systemic lupus erythematosus_Homo sapiens_hsa053220.16826469
94Phenylalanine metabolism_Homo sapiens_hsa003600.15663290
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.14719809
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12089942
97HTLV-I infection_Homo sapiens_hsa051660.10966547
98Chronic myeloid leukemia_Homo sapiens_hsa052200.10562905
99Fatty acid degradation_Homo sapiens_hsa000710.09942916
100Hedgehog signaling pathway_Homo sapiens_hsa043400.09629141

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