

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chaperone-mediated protein transport (GO:0072321) | 4.72169269 |
| 2 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.72150961 |
| 3 | termination of RNA polymerase III transcription (GO:0006386) | 4.72150961 |
| 4 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.45391804 |
| 5 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.45290697 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.42833850 |
| 7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.42833850 |
| 8 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 4.36376498 |
| 9 | cullin deneddylation (GO:0010388) | 4.24397702 |
| 10 | protein deneddylation (GO:0000338) | 4.23582512 |
| 11 | DNA deamination (GO:0045006) | 4.22232931 |
| 12 | protein complex biogenesis (GO:0070271) | 4.22155993 |
| 13 | proteasome assembly (GO:0043248) | 4.20209790 |
| 14 | inositol phosphate dephosphorylation (GO:0046855) | 4.16454522 |
| 15 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 4.16454522 |
| 16 | protein neddylation (GO:0045116) | 4.12885521 |
| 17 | inositol phosphate catabolic process (GO:0071545) | 4.10688740 |
| 18 | cytochrome complex assembly (GO:0017004) | 4.01223162 |
| 19 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.98768288 |
| 20 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.96597352 |
| 21 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.84350254 |
| 22 | regulation of mitochondrial translation (GO:0070129) | 3.82949199 |
| 23 | organelle disassembly (GO:1903008) | 3.82334145 |
| 24 | respiratory chain complex IV assembly (GO:0008535) | 3.79993740 |
| 25 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.78576265 |
| 26 | NADH dehydrogenase complex assembly (GO:0010257) | 3.78576265 |
| 27 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.78576265 |
| 28 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.77401862 |
| 29 | regulation of cilium movement (GO:0003352) | 3.77080124 |
| 30 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.68527264 |
| 31 | electron transport chain (GO:0022900) | 3.67941305 |
| 32 | response to pheromone (GO:0019236) | 3.67935404 |
| 33 | respiratory electron transport chain (GO:0022904) | 3.64254011 |
| 34 | platelet dense granule organization (GO:0060155) | 3.46592611 |
| 35 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.42617471 |
| 36 | GTP biosynthetic process (GO:0006183) | 3.38670172 |
| 37 | 7-methylguanosine mRNA capping (GO:0006370) | 3.33090109 |
| 38 | 7-methylguanosine RNA capping (GO:0009452) | 3.24504950 |
| 39 | RNA capping (GO:0036260) | 3.24504950 |
| 40 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.23780751 |
| 41 | pseudouridine synthesis (GO:0001522) | 3.23497425 |
| 42 | behavioral response to nicotine (GO:0035095) | 3.23143745 |
| 43 | inner mitochondrial membrane organization (GO:0007007) | 3.19865370 |
| 44 | positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357 | 3.19787099 |
| 45 | viral mRNA export from host cell nucleus (GO:0046784) | 3.16923974 |
| 46 | ribonucleoprotein complex disassembly (GO:0032988) | 3.15852817 |
| 47 | polyol catabolic process (GO:0046174) | 3.12160865 |
| 48 | replication fork processing (GO:0031297) | 3.11848269 |
| 49 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.01671511 |
| 50 | hydrogen ion transmembrane transport (GO:1902600) | 3.01279583 |
| 51 | GPI anchor metabolic process (GO:0006505) | 2.99490353 |
| 52 | artery smooth muscle contraction (GO:0014824) | 2.92509827 |
| 53 | negative regulation of heart rate (GO:0010459) | 2.92154063 |
| 54 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.92135109 |
| 55 | UTP biosynthetic process (GO:0006228) | 2.90836178 |
| 56 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.89898187 |
| 57 | proton transport (GO:0015992) | 2.89653158 |
| 58 | pyrimidine ribonucleoside biosynthetic process (GO:0046132) | 2.88283299 |
| 59 | DNA damage response, detection of DNA damage (GO:0042769) | 2.88163554 |
| 60 | hydrogen transport (GO:0006818) | 2.87117076 |
| 61 | DNA double-strand break processing (GO:0000729) | 2.84504589 |
| 62 | nonmotile primary cilium assembly (GO:0035058) | 2.83813263 |
| 63 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.81355622 |
| 64 | signal peptide processing (GO:0006465) | 2.80596193 |
| 65 | ribosome assembly (GO:0042255) | 2.75475591 |
| 66 | regulation of cellular respiration (GO:0043457) | 2.74880681 |
| 67 | protein targeting to mitochondrion (GO:0006626) | 2.73808683 |
| 68 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.73722009 |
| 69 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.73613549 |
| 70 | nucleotide transmembrane transport (GO:1901679) | 2.72963764 |
| 71 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.71143387 |
| 72 | pyrimidine ribonucleotide biosynthetic process (GO:0009220) | 2.69655163 |
| 73 | pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174) | 2.68632931 |
| 74 | UMP metabolic process (GO:0046049) | 2.68632931 |
| 75 | pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173) | 2.68632931 |
| 76 | UMP biosynthetic process (GO:0006222) | 2.68632931 |
| 77 | maturation of 5.8S rRNA (GO:0000460) | 2.68178290 |
| 78 | protein localization to mitochondrion (GO:0070585) | 2.67636380 |
| 79 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.66157009 |
| 80 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.65949637 |
| 81 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.65717628 |
| 82 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.64789634 |
| 83 | transcription from RNA polymerase I promoter (GO:0006360) | 2.64446225 |
| 84 | ATP biosynthetic process (GO:0006754) | 2.63256291 |
| 85 | regulation of regulatory T cell differentiation (GO:0045589) | 2.61405545 |
| 86 | positive regulation of interleukin-17 production (GO:0032740) | 2.61230474 |
| 87 | regulation of microtubule-based movement (GO:0060632) | 2.60953839 |
| 88 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.60615740 |
| 89 | neuronal action potential propagation (GO:0019227) | 2.60293344 |
| 90 | DNA replication checkpoint (GO:0000076) | 2.60192475 |
| 91 | brain morphogenesis (GO:0048854) | 2.58613191 |
| 92 | termination of RNA polymerase I transcription (GO:0006363) | 2.56601281 |
| 93 | tRNA processing (GO:0008033) | 2.56458328 |
| 94 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.56226130 |
| 95 | UTP metabolic process (GO:0046051) | 2.55792547 |
| 96 | serotonin receptor signaling pathway (GO:0007210) | 2.55788975 |
| 97 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.55324358 |
| 98 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.55324358 |
| 99 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.55324358 |
| 100 | establishment of protein localization to mitochondrion (GO:0072655) | 2.53149498 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.21599373 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.14453565 |
| 3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.66602769 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.23197578 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.13655957 |
| 6 | VDR_22108803_ChIP-Seq_LS180_Human | 3.00888202 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.96941601 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.79178631 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.60956105 |
| 10 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.56482959 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.52943341 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.49541220 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.44841141 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.43772834 |
| 15 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.38229135 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.22342564 |
| 17 | EWS_26573619_Chip-Seq_HEK293_Human | 2.14745415 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.08808611 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.02175400 |
| 20 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.96313680 |
| 21 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.93853757 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.91449086 |
| 23 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.87936728 |
| 24 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.86164338 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.83099261 |
| 26 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.77892830 |
| 27 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.76822509 |
| 28 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.76290645 |
| 29 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.76290645 |
| 30 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.73663192 |
| 31 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.72474847 |
| 32 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.70475398 |
| 33 | P300_19829295_ChIP-Seq_ESCs_Human | 1.68203082 |
| 34 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.67296166 |
| 35 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.66028970 |
| 36 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.65363177 |
| 37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.61950443 |
| 38 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.58745976 |
| 39 | FUS_26573619_Chip-Seq_HEK293_Human | 1.43796250 |
| 40 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.43488382 |
| 41 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.43394996 |
| 42 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.42738768 |
| 43 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.40738478 |
| 44 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.38924297 |
| 45 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.38917555 |
| 46 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.37743518 |
| 47 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.37041930 |
| 48 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.36960704 |
| 49 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.35147997 |
| 50 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.34891816 |
| 51 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.32351355 |
| 52 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.28074042 |
| 53 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.27666532 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.26476392 |
| 55 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.24617442 |
| 56 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.24617442 |
| 57 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.23750863 |
| 58 | AR_20517297_ChIP-Seq_VCAP_Human | 1.21461155 |
| 59 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.21161809 |
| 60 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.19245468 |
| 61 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.14641340 |
| 62 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.14447770 |
| 63 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.14387391 |
| 64 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.12366475 |
| 65 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.10896678 |
| 66 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.10134977 |
| 67 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.09991648 |
| 68 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.09358994 |
| 69 | NCOR_22424771_ChIP-Seq_293T_Human | 1.09114798 |
| 70 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.08485255 |
| 71 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.08138206 |
| 72 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.08085660 |
| 73 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.06318792 |
| 74 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.05829885 |
| 75 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.05387236 |
| 76 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.05262295 |
| 77 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.04645493 |
| 78 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.03680553 |
| 79 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.03645900 |
| 80 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.01133799 |
| 81 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.00237396 |
| 82 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.99203968 |
| 83 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.99117189 |
| 84 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.99117189 |
| 85 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.97672559 |
| 86 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.97346908 |
| 87 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.95736608 |
| 88 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.95358706 |
| 89 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.94850002 |
| 90 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.93712394 |
| 91 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.93470026 |
| 92 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.93451151 |
| 93 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.93248349 |
| 94 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.93137951 |
| 95 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.93119988 |
| 96 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.92888162 |
| 97 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.92505776 |
| 98 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.92389974 |
| 99 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.91884993 |
| 100 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.90905644 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.58451093 |
| 2 | MP0002102_abnormal_ear_morphology | 3.31904170 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.23416039 |
| 4 | MP0003880_abnormal_central_pattern | 2.90874596 |
| 5 | MP0003195_calcinosis | 2.88126055 |
| 6 | MP0006072_abnormal_retinal_apoptosis | 2.84154493 |
| 7 | MP0000569_abnormal_digit_pigmentation | 2.82639417 |
| 8 | MP0001984_abnormal_olfaction | 2.68427797 |
| 9 | MP0003806_abnormal_nucleotide_metabolis | 2.67196155 |
| 10 | MP0005084_abnormal_gallbladder_morpholo | 2.36635121 |
| 11 | MP0010386_abnormal_urinary_bladder | 2.21395162 |
| 12 | MP0006276_abnormal_autonomic_nervous | 2.20527506 |
| 13 | MP0004147_increased_porphyrin_level | 2.18641866 |
| 14 | MP0003787_abnormal_imprinting | 2.16077611 |
| 15 | MP0005645_abnormal_hypothalamus_physiol | 1.98986401 |
| 16 | MP0008872_abnormal_physiological_respon | 1.96814297 |
| 17 | MP0001986_abnormal_taste_sensitivity | 1.92095050 |
| 18 | MP0005551_abnormal_eye_electrophysiolog | 1.89704230 |
| 19 | MP0003718_maternal_effect | 1.78505003 |
| 20 | MP0009046_muscle_twitch | 1.78282947 |
| 21 | MP0001968_abnormal_touch/_nociception | 1.75648861 |
| 22 | MP0003011_delayed_dark_adaptation | 1.75059747 |
| 23 | MP0003693_abnormal_embryo_hatching | 1.71452717 |
| 24 | MP0002254_reproductive_system_inflammat | 1.69931843 |
| 25 | MP0005379_endocrine/exocrine_gland_phen | 1.66297710 |
| 26 | MP0001905_abnormal_dopamine_level | 1.66183936 |
| 27 | MP0002837_dystrophic_cardiac_calcinosis | 1.65451108 |
| 28 | MP0004885_abnormal_endolymph | 1.59296229 |
| 29 | MP0000372_irregular_coat_pigmentation | 1.57042174 |
| 30 | MP0001529_abnormal_vocalization | 1.56735737 |
| 31 | MP0002876_abnormal_thyroid_physiology | 1.54711920 |
| 32 | MP0002234_abnormal_pharynx_morphology | 1.52679626 |
| 33 | MP0008875_abnormal_xenobiotic_pharmacok | 1.49138894 |
| 34 | MP0005389_reproductive_system_phenotype | 1.48578073 |
| 35 | MP0000631_abnormal_neuroendocrine_gland | 1.48534706 |
| 36 | MP0000427_abnormal_hair_cycle | 1.47138279 |
| 37 | MP0004142_abnormal_muscle_tone | 1.43099411 |
| 38 | MP0009697_abnormal_copulation | 1.42195609 |
| 39 | MP0001835_abnormal_antigen_presentation | 1.38883087 |
| 40 | MP0006292_abnormal_olfactory_placode | 1.38098677 |
| 41 | MP0002736_abnormal_nociception_after | 1.37684688 |
| 42 | MP0004742_abnormal_vestibular_system | 1.35908630 |
| 43 | MP0005410_abnormal_fertilization | 1.34533753 |
| 44 | MP0006035_abnormal_mitochondrial_morpho | 1.34329080 |
| 45 | MP0001919_abnormal_reproductive_system | 1.32413347 |
| 46 | MP0006036_abnormal_mitochondrial_physio | 1.29547207 |
| 47 | MP0005636_abnormal_mineral_homeostasis | 1.25197250 |
| 48 | MP0001485_abnormal_pinna_reflex | 1.24970608 |
| 49 | MP0005253_abnormal_eye_physiology | 1.22803460 |
| 50 | MP0002138_abnormal_hepatobiliary_system | 1.21028784 |
| 51 | MP0005075_abnormal_melanosome_morpholog | 1.19073437 |
| 52 | MP0002638_abnormal_pupillary_reflex | 1.17893482 |
| 53 | MP0001486_abnormal_startle_reflex | 1.17440807 |
| 54 | MP0002160_abnormal_reproductive_system | 1.15970826 |
| 55 | MP0010094_abnormal_chromosome_stability | 1.14147153 |
| 56 | MP0004145_abnormal_muscle_electrophysio | 1.11356742 |
| 57 | MP0005167_abnormal_blood-brain_barrier | 1.09839141 |
| 58 | MP0009745_abnormal_behavioral_response | 1.08348230 |
| 59 | MP0003786_premature_aging | 1.03651061 |
| 60 | MP0008789_abnormal_olfactory_epithelium | 1.02275181 |
| 61 | MP0002272_abnormal_nervous_system | 1.01607933 |
| 62 | MP0005310_abnormal_salivary_gland | 0.96488417 |
| 63 | MP0001188_hyperpigmentation | 0.95399287 |
| 64 | MP0003123_paternal_imprinting | 0.94879988 |
| 65 | MP0003121_genomic_imprinting | 0.91060132 |
| 66 | MP0001501_abnormal_sleep_pattern | 0.90143306 |
| 67 | MP0002090_abnormal_vision | 0.87946428 |
| 68 | MP0004084_abnormal_cardiac_muscle | 0.87131749 |
| 69 | MP0004019_abnormal_vitamin_homeostasis | 0.86878146 |
| 70 | MP0004215_abnormal_myocardial_fiber | 0.85957882 |
| 71 | MP0005646_abnormal_pituitary_gland | 0.85787799 |
| 72 | MP0003937_abnormal_limbs/digits/tail_de | 0.85531881 |
| 73 | MP0005332_abnormal_amino_acid | 0.85341206 |
| 74 | MP0003567_abnormal_fetal_cardiomyocyte | 0.82455910 |
| 75 | MP0002734_abnormal_mechanical_nocicepti | 0.82328126 |
| 76 | MP0004782_abnormal_surfactant_physiolog | 0.81591952 |
| 77 | MP0003646_muscle_fatigue | 0.80774152 |
| 78 | MP0004957_abnormal_blastocyst_morpholog | 0.79781743 |
| 79 | MP0009764_decreased_sensitivity_to | 0.77736384 |
| 80 | MP0004043_abnormal_pH_regulation | 0.76229526 |
| 81 | MP0004036_abnormal_muscle_relaxation | 0.75166096 |
| 82 | MP0001970_abnormal_pain_threshold | 0.74251391 |
| 83 | MP0004133_heterotaxia | 0.74105235 |
| 84 | MP0002938_white_spotting | 0.73211216 |
| 85 | MP0005174_abnormal_tail_pigmentation | 0.72858340 |
| 86 | MP0001929_abnormal_gametogenesis | 0.72630522 |
| 87 | MP0002735_abnormal_chemical_nociception | 0.72460643 |
| 88 | MP0008961_abnormal_basal_metabolism | 0.70238438 |
| 89 | MP0000465_gastrointestinal_hemorrhage | 0.68818766 |
| 90 | MP0000538_abnormal_urinary_bladder | 0.68195442 |
| 91 | MP0001764_abnormal_homeostasis | 0.66509281 |
| 92 | MP0003698_abnormal_male_reproductive | 0.65699057 |
| 93 | MP0002064_seizures | 0.65677058 |
| 94 | MP0005394_taste/olfaction_phenotype | 0.65669453 |
| 95 | MP0005499_abnormal_olfactory_system | 0.65669453 |
| 96 | MP0001293_anophthalmia | 0.65430212 |
| 97 | MP0005266_abnormal_metabolism | 0.64134132 |
| 98 | MP0000358_abnormal_cell_content/ | 0.63129030 |
| 99 | MP0005647_abnormal_sex_gland | 0.63006558 |
| 100 | MP0002210_abnormal_sex_determination | 0.62682423 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.18750579 |
| 2 | 3-Methylglutaconic aciduria (HP:0003535) | 3.95681621 |
| 3 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.81692738 |
| 4 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.81692738 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.67625210 |
| 6 | Increased CSF lactate (HP:0002490) | 3.63645760 |
| 7 | Methylmalonic acidemia (HP:0002912) | 3.62162789 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.61026922 |
| 9 | Acute encephalopathy (HP:0006846) | 3.52736738 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.45144753 |
| 11 | Septo-optic dysplasia (HP:0100842) | 3.36306621 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.14640385 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.00986090 |
| 14 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.94356783 |
| 15 | Hepatocellular necrosis (HP:0001404) | 2.92173579 |
| 16 | Abnormality of midbrain morphology (HP:0002418) | 2.84575307 |
| 17 | Molar tooth sign on MRI (HP:0002419) | 2.84575307 |
| 18 | Methylmalonic aciduria (HP:0012120) | 2.82661631 |
| 19 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.82487634 |
| 20 | Medial flaring of the eyebrow (HP:0010747) | 2.79576044 |
| 21 | Progressive inability to walk (HP:0002505) | 2.75938960 |
| 22 | Cerebral edema (HP:0002181) | 2.67328642 |
| 23 | Hepatic necrosis (HP:0002605) | 2.65852756 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.64857436 |
| 25 | Increased serum lactate (HP:0002151) | 2.63628336 |
| 26 | Unilateral renal agenesis (HP:0000122) | 2.60784527 |
| 27 | Lactic acidosis (HP:0003128) | 2.57429506 |
| 28 | Type I transferrin isoform profile (HP:0003642) | 2.56212687 |
| 29 | Agitation (HP:0000713) | 2.54755554 |
| 30 | Abnormality of the pons (HP:0007361) | 2.49327033 |
| 31 | Inability to walk (HP:0002540) | 2.45556386 |
| 32 | Abnormality of vitamin B metabolism (HP:0004340) | 2.35895855 |
| 33 | Microvesicular hepatic steatosis (HP:0001414) | 2.31201891 |
| 34 | Optic disc pallor (HP:0000543) | 2.29500443 |
| 35 | Abnormal protein glycosylation (HP:0012346) | 2.29367239 |
| 36 | Abnormal glycosylation (HP:0012345) | 2.29367239 |
| 37 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.29367239 |
| 38 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.29367239 |
| 39 | Gait imbalance (HP:0002141) | 2.28456765 |
| 40 | Absent/shortened dynein arms (HP:0200106) | 2.24993518 |
| 41 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.24993518 |
| 42 | Congenital primary aphakia (HP:0007707) | 2.22235609 |
| 43 | Adrenal hypoplasia (HP:0000835) | 2.21260100 |
| 44 | Pendular nystagmus (HP:0012043) | 2.19057795 |
| 45 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.18125454 |
| 46 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.18125454 |
| 47 | Abolished electroretinogram (ERG) (HP:0000550) | 2.17960368 |
| 48 | Absent septum pellucidum (HP:0001331) | 2.17537081 |
| 49 | Constricted visual fields (HP:0001133) | 2.15568847 |
| 50 | Congenital, generalized hypertrichosis (HP:0004540) | 2.15329386 |
| 51 | Pancreatic cysts (HP:0001737) | 2.12325783 |
| 52 | Abnormal sex determination (HP:0012244) | 2.09769773 |
| 53 | Sex reversal (HP:0012245) | 2.09769773 |
| 54 | Hypoproteinemia (HP:0003075) | 2.09218939 |
| 55 | Hypomagnesemia (HP:0002917) | 2.07454913 |
| 56 | Lethargy (HP:0001254) | 2.06774193 |
| 57 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.04858607 |
| 58 | True hermaphroditism (HP:0010459) | 2.04633825 |
| 59 | Nephrogenic diabetes insipidus (HP:0009806) | 2.00736825 |
| 60 | Focal motor seizures (HP:0011153) | 1.99095956 |
| 61 | Pancreatic fibrosis (HP:0100732) | 1.98793970 |
| 62 | Abnormality of the prostate (HP:0008775) | 1.98564688 |
| 63 | Cerebral hypomyelination (HP:0006808) | 1.97675626 |
| 64 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.97478042 |
| 65 | Renal Fanconi syndrome (HP:0001994) | 1.97239757 |
| 66 | Keratoconus (HP:0000563) | 1.96624457 |
| 67 | Increased corneal curvature (HP:0100692) | 1.96624457 |
| 68 | Global brain atrophy (HP:0002283) | 1.94940634 |
| 69 | Respiratory failure (HP:0002878) | 1.94892247 |
| 70 | Nephronophthisis (HP:0000090) | 1.91180994 |
| 71 | Abnormal biliary tract physiology (HP:0012439) | 1.90762734 |
| 72 | Bile duct proliferation (HP:0001408) | 1.90762734 |
| 73 | Leukodystrophy (HP:0002415) | 1.90728870 |
| 74 | Hypoplasia of the pons (HP:0012110) | 1.90214334 |
| 75 | Large for gestational age (HP:0001520) | 1.90144453 |
| 76 | Abnormal number of erythroid precursors (HP:0012131) | 1.88854403 |
| 77 | Congenital stationary night blindness (HP:0007642) | 1.87415622 |
| 78 | Overlapping toe (HP:0001845) | 1.86928434 |
| 79 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.86270474 |
| 80 | Prolonged neonatal jaundice (HP:0006579) | 1.86094198 |
| 81 | Exertional dyspnea (HP:0002875) | 1.85213473 |
| 82 | Abnormality of dental color (HP:0011073) | 1.82756205 |
| 83 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.82088312 |
| 84 | Dicarboxylic aciduria (HP:0003215) | 1.82088312 |
| 85 | Exercise intolerance (HP:0003546) | 1.82044541 |
| 86 | Abnormality of the anterior horn cell (HP:0006802) | 1.80940870 |
| 87 | Degeneration of anterior horn cells (HP:0002398) | 1.80940870 |
| 88 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.80456336 |
| 89 | Increased intramyocellular lipid droplets (HP:0012240) | 1.80327239 |
| 90 | Parakeratosis (HP:0001036) | 1.79603493 |
| 91 | Abnormal ciliary motility (HP:0012262) | 1.79577228 |
| 92 | Reduced antithrombin III activity (HP:0001976) | 1.78712862 |
| 93 | Restlessness (HP:0000711) | 1.77556466 |
| 94 | Increased serum pyruvate (HP:0003542) | 1.77347430 |
| 95 | Muscular hypotonia of the trunk (HP:0008936) | 1.76314176 |
| 96 | Male pseudohermaphroditism (HP:0000037) | 1.75374281 |
| 97 | Aplastic anemia (HP:0001915) | 1.75059950 |
| 98 | Renal salt wasting (HP:0000127) | 1.72348278 |
| 99 | Intestinal atresia (HP:0011100) | 1.71443941 |
| 100 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.71422629 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 2.75164799 |
| 2 | MST4 | 2.67929300 |
| 3 | TIE1 | 2.63942103 |
| 4 | PINK1 | 2.59919005 |
| 5 | WNK3 | 2.44686897 |
| 6 | TRIM28 | 2.41275963 |
| 7 | EIF2AK3 | 2.41210375 |
| 8 | ZAK | 2.29682495 |
| 9 | BRSK2 | 2.21953603 |
| 10 | GRK1 | 2.21401023 |
| 11 | OXSR1 | 2.03411783 |
| 12 | SRPK1 | 2.01843596 |
| 13 | MAP4K2 | 1.88925156 |
| 14 | STK39 | 1.86106440 |
| 15 | NUAK1 | 1.84568605 |
| 16 | TXK | 1.77743806 |
| 17 | CDK8 | 1.77509783 |
| 18 | PLK3 | 1.77278045 |
| 19 | CAMKK2 | 1.77091180 |
| 20 | PHKG2 | 1.72719406 |
| 21 | PHKG1 | 1.72719406 |
| 22 | DYRK2 | 1.70064020 |
| 23 | VRK2 | 1.69224566 |
| 24 | CSNK1G3 | 1.64858687 |
| 25 | BMPR1B | 1.64682037 |
| 26 | TEC | 1.64258005 |
| 27 | CSNK1A1L | 1.62770220 |
| 28 | VRK1 | 1.62066035 |
| 29 | TLK1 | 1.55952706 |
| 30 | ADRBK2 | 1.53764584 |
| 31 | BCKDK | 1.51783314 |
| 32 | MAP3K4 | 1.50658292 |
| 33 | CSNK1G2 | 1.47334071 |
| 34 | EIF2AK1 | 1.46987142 |
| 35 | BCR | 1.46470726 |
| 36 | BUB1 | 1.42249728 |
| 37 | MKNK1 | 1.40901668 |
| 38 | MAP2K7 | 1.39652114 |
| 39 | WNK4 | 1.36153615 |
| 40 | MKNK2 | 1.34810586 |
| 41 | CSNK1G1 | 1.33128624 |
| 42 | TSSK6 | 1.32302439 |
| 43 | NEK1 | 1.31010564 |
| 44 | MAP3K12 | 1.22901375 |
| 45 | CDK19 | 1.22624265 |
| 46 | INSRR | 1.21331648 |
| 47 | FGFR2 | 1.07045926 |
| 48 | PLK4 | 1.04336076 |
| 49 | PBK | 0.98437533 |
| 50 | PRKCE | 0.96712670 |
| 51 | MINK1 | 0.94839666 |
| 52 | PAK3 | 0.92055572 |
| 53 | RPS6KA4 | 0.91269265 |
| 54 | PLK2 | 0.89983062 |
| 55 | MAPK13 | 0.86486553 |
| 56 | EIF2AK2 | 0.78895393 |
| 57 | BRSK1 | 0.75528168 |
| 58 | RPS6KA5 | 0.74320029 |
| 59 | PLK1 | 0.73567686 |
| 60 | STK3 | 0.66396408 |
| 61 | KIT | 0.65067778 |
| 62 | STK38L | 0.64343318 |
| 63 | ALK | 0.63527564 |
| 64 | DAPK2 | 0.59362743 |
| 65 | ERBB3 | 0.58843810 |
| 66 | CHEK2 | 0.55764381 |
| 67 | ACVR1B | 0.55218071 |
| 68 | CSNK2A2 | 0.53176335 |
| 69 | PRKCI | 0.53117613 |
| 70 | TNIK | 0.52552780 |
| 71 | CASK | 0.52047440 |
| 72 | RPS6KB2 | 0.51680055 |
| 73 | PRKCG | 0.51219052 |
| 74 | MAP3K14 | 0.51092812 |
| 75 | ITK | 0.49517086 |
| 76 | WEE1 | 0.48734120 |
| 77 | CSNK1A1 | 0.48548273 |
| 78 | TAF1 | 0.46451079 |
| 79 | IGF1R | 0.43253055 |
| 80 | TTK | 0.39675123 |
| 81 | PRKACA | 0.39251061 |
| 82 | YES1 | 0.38818092 |
| 83 | EGFR | 0.38623828 |
| 84 | CSNK2A1 | 0.37543055 |
| 85 | CAMK2A | 0.37436324 |
| 86 | MATK | 0.37331520 |
| 87 | ATR | 0.36572724 |
| 88 | PRKG1 | 0.33571625 |
| 89 | PRKCA | 0.32595763 |
| 90 | DYRK3 | 0.32381661 |
| 91 | ABL1 | 0.32303501 |
| 92 | TGFBR1 | 0.31639252 |
| 93 | PRKCQ | 0.29981344 |
| 94 | ATM | 0.29952002 |
| 95 | LYN | 0.28070742 |
| 96 | FES | 0.28011932 |
| 97 | PRKG2 | 0.27466514 |
| 98 | MYLK | 0.27187137 |
| 99 | ADRBK1 | 0.26929521 |
| 100 | GRK5 | 0.26682852 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protein export_Homo sapiens_hsa03060 | 3.86105491 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.80687884 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.56732621 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.35156349 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.95002482 |
| 6 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.49910953 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.19427605 |
| 8 | Basal transcription factors_Homo sapiens_hsa03022 | 2.17134328 |
| 9 | Asthma_Homo sapiens_hsa05310 | 2.08684658 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.02545208 |
| 11 | Huntingtons disease_Homo sapiens_hsa05016 | 2.00196636 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.99992990 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 1.91751429 |
| 14 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.87135577 |
| 15 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.81050021 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.73592798 |
| 17 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.70877546 |
| 18 | Phototransduction_Homo sapiens_hsa04744 | 1.66638899 |
| 19 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.62005871 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.60878055 |
| 21 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.60582497 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.58680310 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.55467067 |
| 24 | Homologous recombination_Homo sapiens_hsa03440 | 1.51331803 |
| 25 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.45349809 |
| 26 | Allograft rejection_Homo sapiens_hsa05330 | 1.43848479 |
| 27 | RNA transport_Homo sapiens_hsa03013 | 1.42628872 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.41164503 |
| 29 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.38465376 |
| 30 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.33056528 |
| 31 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.29022129 |
| 32 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.28723111 |
| 33 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.28049791 |
| 34 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.20100325 |
| 35 | Base excision repair_Homo sapiens_hsa03410 | 1.19972273 |
| 36 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.19646079 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.14660120 |
| 38 | Spliceosome_Homo sapiens_hsa03040 | 1.14293437 |
| 39 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.11814462 |
| 40 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.11248717 |
| 41 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.09874111 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.08208639 |
| 43 | DNA replication_Homo sapiens_hsa03030 | 1.05693164 |
| 44 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.05605300 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.04904571 |
| 46 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.04411521 |
| 47 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.02653913 |
| 48 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.00269216 |
| 49 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.97761008 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.92408919 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.91879816 |
| 52 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.91666635 |
| 53 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.90775465 |
| 54 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.88005344 |
| 55 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.87369776 |
| 56 | Mismatch repair_Homo sapiens_hsa03430 | 0.77075161 |
| 57 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.75464666 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.73927541 |
| 59 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.73874430 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.73123655 |
| 61 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.70928150 |
| 62 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.69113667 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.67395361 |
| 64 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.66612565 |
| 65 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.63887893 |
| 66 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.63708889 |
| 67 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.61698801 |
| 68 | Retinol metabolism_Homo sapiens_hsa00830 | 0.58743371 |
| 69 | Olfactory transduction_Homo sapiens_hsa04740 | 0.57626018 |
| 70 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.57529087 |
| 71 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.57382715 |
| 72 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.56298459 |
| 73 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.55831874 |
| 74 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.51813304 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.49801724 |
| 76 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.48478235 |
| 77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.45498074 |
| 78 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45468459 |
| 79 | Nicotine addiction_Homo sapiens_hsa05033 | 0.45375486 |
| 80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.41533883 |
| 81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.38916731 |
| 82 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.38512027 |
| 83 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.38180602 |
| 84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.37791715 |
| 85 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.37591725 |
| 86 | Morphine addiction_Homo sapiens_hsa05032 | 0.37347536 |
| 87 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.35365071 |
| 88 | Sulfur relay system_Homo sapiens_hsa04122 | 0.35018381 |
| 89 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.33449595 |
| 90 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.32005522 |
| 91 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.31666877 |
| 92 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.31480533 |
| 93 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.30857099 |
| 94 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.30174986 |
| 95 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.28017192 |
| 96 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.27921500 |
| 97 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.27903108 |
| 98 | Salivary secretion_Homo sapiens_hsa04970 | 0.27695509 |
| 99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.26743523 |
| 100 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.26406169 |

