CCT6P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oocyte development (GO:0048599)5.78863682
2multicellular organism reproduction (GO:0032504)5.73591253
3positive regulation of meiosis (GO:0045836)5.38903485
4gonadal mesoderm development (GO:0007506)5.09364300
5positive regulation of meiotic cell cycle (GO:0051446)5.08141192
6regulation of RIG-I signaling pathway (GO:0039535)5.06640169
7synaptonemal complex organization (GO:0070193)5.04629823
8regulation of exit from mitosis (GO:0007096)5.02292448
9male meiosis I (GO:0007141)5.00492443
10synaptonemal complex assembly (GO:0007130)4.84650988
11regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.70111647
12histone lysine demethylation (GO:0070076)4.62939570
13regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.52058150
14piRNA metabolic process (GO:0034587)4.46767169
15histone demethylation (GO:0016577)4.38710031
16male meiosis (GO:0007140)4.24253917
17regulation of acrosome reaction (GO:0060046)4.23817755
18single fertilization (GO:0007338)4.17151777
19DNA replication-dependent nucleosome assembly (GO:0006335)4.00905165
20DNA replication-dependent nucleosome organization (GO:0034723)4.00905165
21protein dealkylation (GO:0008214)3.97109108
22protein demethylation (GO:0006482)3.97109108
23negative regulation of synaptic transmission, GABAergic (GO:0032229)3.90114797
24negative regulation of Ras GTPase activity (GO:0034261)3.81194966
25behavioral response to nicotine (GO:0035095)3.78546563
26RNA destabilization (GO:0050779)3.73401214
27meiosis I (GO:0007127)3.73260937
28regulation of female receptivity (GO:0045924)3.67814845
29protein K6-linked ubiquitination (GO:0085020)3.66967483
30chromosome organization involved in meiosis (GO:0070192)3.66482947
31acrosome reaction (GO:0007340)3.66085871
32protein K48-linked deubiquitination (GO:0071108)3.63662563
33positive regulation of catecholamine secretion (GO:0033605)3.58876983
34binding of sperm to zona pellucida (GO:0007339)3.48753048
35reproduction (GO:0000003)3.48610660
36epithelial cilium movement (GO:0003351)3.48006638
37regulation of meiosis (GO:0040020)3.46856346
38telomere maintenance via telomerase (GO:0007004)3.40185860
39centriole replication (GO:0007099)3.39578546
40double-strand break repair via homologous recombination (GO:0000724)3.38654103
41recombinational repair (GO:0000725)3.33372261
42positive regulation of uterine smooth muscle contraction (GO:0070474)3.33371287
43female mating behavior (GO:0060180)3.32406226
44sperm-egg recognition (GO:0035036)3.32260329
45DNA double-strand break processing (GO:0000729)3.31519068
46hindbrain development (GO:0030902)3.29284742
47response to UV-C (GO:0010225)3.28537289
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.28365804
49mitochondrial RNA metabolic process (GO:0000959)3.28257862
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.27101581
51cilium movement (GO:0003341)3.22155600
52regulation of meiotic cell cycle (GO:0051445)3.20991111
53endoderm formation (GO:0001706)3.20041723
54fertilization (GO:0009566)3.18091378
55reciprocal DNA recombination (GO:0035825)3.10980797
56reciprocal meiotic recombination (GO:0007131)3.10980797
57mitochondrial respiratory chain complex assembly (GO:0033108)3.10561718
58proteasome assembly (GO:0043248)3.07407311
59postsynaptic membrane organization (GO:0001941)3.05560212
60protein-cofactor linkage (GO:0018065)3.05478916
61meiotic cell cycle process (GO:1903046)3.05210423
62regulation of centriole replication (GO:0046599)3.04058637
63regulation of ruffle assembly (GO:1900027)3.03000979
64kynurenine metabolic process (GO:0070189)3.01635892
65artery development (GO:0060840)3.01579733
66tryptophan catabolic process (GO:0006569)3.01295947
67indole-containing compound catabolic process (GO:0042436)3.01295947
68indolalkylamine catabolic process (GO:0046218)3.01295947
69somite rostral/caudal axis specification (GO:0032525)3.00490440
70indolalkylamine metabolic process (GO:0006586)3.00327429
71phosphorelay signal transduction system (GO:0000160)2.99965917
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.99475666
73NADH dehydrogenase complex assembly (GO:0010257)2.99475666
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99475666
75DNA methylation involved in gamete generation (GO:0043046)2.98604039
76regulation of mRNA splicing, via spliceosome (GO:0048024)2.96036055
77phosphate ion homeostasis (GO:0055062)2.95900946
78trivalent inorganic anion homeostasis (GO:0072506)2.95900946
79meiotic cell cycle (GO:0051321)2.95643475
80positive regulation of prostaglandin secretion (GO:0032308)2.94894162
81regulation of cytokine production involved in inflammatory response (GO:1900015)2.94817843
82regulation of helicase activity (GO:0051095)2.94199738
83regulation of DNA endoreduplication (GO:0032875)2.90789988
84protein K63-linked deubiquitination (GO:0070536)2.89446191
85spermatid development (GO:0007286)2.88870498
86histone mRNA catabolic process (GO:0071044)2.88280997
87aggressive behavior (GO:0002118)2.86897840
88mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.84568979
89cellular anion homeostasis (GO:0030002)2.83832765
90cell-cell recognition (GO:0009988)2.82556403
91N-terminal protein amino acid acetylation (GO:0006474)2.80369310
92peristalsis (GO:0030432)2.77770514
93phasic smooth muscle contraction (GO:0014821)2.77088274
94regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.74064482
95tryptophan metabolic process (GO:0006568)2.72948949
96cell proliferation in forebrain (GO:0021846)2.70979745
97pseudouridine synthesis (GO:0001522)2.68599904
98cochlea development (GO:0090102)2.68473851
99negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67714089
100histone H3-K9 demethylation (GO:0033169)13.5334778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.66722808
2EZH2_22144423_ChIP-Seq_EOC_Human4.95293595
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23232305
4VDR_22108803_ChIP-Seq_LS180_Human4.17766062
5IRF1_19129219_ChIP-ChIP_H3396_Human3.24459009
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88518612
7ZNF274_21170338_ChIP-Seq_K562_Hela2.87348842
8IGF1R_20145208_ChIP-Seq_DFB_Human2.62946880
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62009059
10GBX2_23144817_ChIP-Seq_PC3_Human2.47802217
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30200326
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26122603
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.20007325
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17998656
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07319603
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95780716
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92675105
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92360925
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.84638945
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.82804862
21E2F7_22180533_ChIP-Seq_HELA_Human1.82736810
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.82431125
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79912072
24P300_19829295_ChIP-Seq_ESCs_Human1.77944815
25TOP2B_26459242_ChIP-Seq_MCF-7_Human1.77824242
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76970843
27MYC_18940864_ChIP-ChIP_HL60_Human1.76796395
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76102624
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.69585313
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69122714
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64576856
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63426448
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63136142
34TCF4_23295773_ChIP-Seq_U87_Human1.60190476
35EWS_26573619_Chip-Seq_HEK293_Human1.58693335
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55700396
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55234361
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.54496093
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52623910
40TAF15_26573619_Chip-Seq_HEK293_Human1.50060056
41SMAD4_21799915_ChIP-Seq_A2780_Human1.49916104
42FUS_26573619_Chip-Seq_HEK293_Human1.47001342
43STAT3_23295773_ChIP-Seq_U87_Human1.46937316
44NCOR_22424771_ChIP-Seq_293T_Human1.46839424
45PRDM14_20953172_ChIP-Seq_ESCs_Human1.45140641
46RNF2_27304074_Chip-Seq_NSC_Mouse1.43434722
47AR_25329375_ChIP-Seq_VCAP_Human1.43260603
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.42722986
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40004696
50TCF4_22108803_ChIP-Seq_LS180_Human1.39184758
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36928447
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.36101943
53BCAT_22108803_ChIP-Seq_LS180_Human1.35653066
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35306658
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35016435
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.33220852
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32710280
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32577044
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30206633
60CBP_20019798_ChIP-Seq_JUKART_Human1.30206633
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.29357700
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.28248532
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27485308
64TP53_22573176_ChIP-Seq_HFKS_Human1.22529563
65AR_21909140_ChIP-Seq_LNCAP_Human1.22465521
66CBP_21632823_ChIP-Seq_H3396_Human1.22105197
67RXR_22108803_ChIP-Seq_LS180_Human1.20540761
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18952561
69RUNX2_22187159_ChIP-Seq_PCA_Human1.18414812
70SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.17748968
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.16886343
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15797219
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15567146
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.13188061
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.08578058
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08307425
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07722959
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06677890
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03962272
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.02768230
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02735857
82VDR_23849224_ChIP-Seq_CD4+_Human1.02582684
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02180707
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02174804
85AR_21572438_ChIP-Seq_LNCaP_Human1.01078390
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01020733
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.00918507
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.98901525
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.97875977
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97580504
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94978557
92REST_21632747_ChIP-Seq_MESCs_Mouse0.94410208
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93711154
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.91623649
95HTT_18923047_ChIP-ChIP_STHdh_Human0.89084487
96GATA3_26560356_Chip-Seq_TH1_Human0.88215620
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87426152
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87078969
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.86240080
100SMRT_27268052_Chip-Seq_Bcells_Human0.86234825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.36971910
2MP0003283_abnormal_digestive_organ4.30928669
3MP0002160_abnormal_reproductive_system3.27562552
4MP0005410_abnormal_fertilization3.11992724
5MP0003950_abnormal_plasma_membrane2.99040558
6MP0000427_abnormal_hair_cycle2.94700997
7MP0003693_abnormal_embryo_hatching2.86516230
8MP0008058_abnormal_DNA_repair2.79051677
9MP0003136_yellow_coat_color2.58467701
10MP0008877_abnormal_DNA_methylation2.40250873
11MP0003183_abnormal_peptide_metabolism2.35524331
12MP0001929_abnormal_gametogenesis2.20538831
13MP0000678_abnormal_parathyroid_gland2.15123114
14MP0010094_abnormal_chromosome_stability2.07251537
15MP0002210_abnormal_sex_determination2.06108832
16MP0002751_abnormal_autonomic_nervous2.04185247
17MP0005389_reproductive_system_phenotype1.96507563
18MP0003718_maternal_effect1.96327573
19MP0002277_abnormal_respiratory_mucosa1.94214258
20MP0003119_abnormal_digestive_system1.94096855
21MP0006276_abnormal_autonomic_nervous1.92548421
22MP0005360_urolithiasis1.86925995
23MP0006072_abnormal_retinal_apoptosis1.74808508
24MP0002138_abnormal_hepatobiliary_system1.74447340
25MP0000049_abnormal_middle_ear1.68138380
26MP0001501_abnormal_sleep_pattern1.66124260
27MP0005220_abnormal_exocrine_pancreas1.65766711
28MP0005647_abnormal_sex_gland1.64510560
29MP0004043_abnormal_pH_regulation1.61771032
30MP0001664_abnormal_digestion1.57358622
31MP0001502_abnormal_circadian_rhythm1.56639414
32MP0000653_abnormal_sex_gland1.52507939
33MP0000631_abnormal_neuroendocrine_gland1.49986608
34MP0005253_abnormal_eye_physiology1.44166439
35MP0003890_abnormal_embryonic-extraembry1.43304472
36MP0001986_abnormal_taste_sensitivity1.41013075
37MP0005084_abnormal_gallbladder_morpholo1.39691443
38MP0003698_abnormal_male_reproductive1.39674617
39MP0003699_abnormal_female_reproductive1.37037162
40MP0001145_abnormal_male_reproductive1.35606929
41MP0005646_abnormal_pituitary_gland1.34277061
42MP0002272_abnormal_nervous_system1.31992221
43MP0003938_abnormal_ear_development1.31899966
44MP0002876_abnormal_thyroid_physiology1.30671367
45MP0005551_abnormal_eye_electrophysiolog1.29438617
46MP0004742_abnormal_vestibular_system1.27891066
47MP0001119_abnormal_female_reproductive1.26530567
48MP0003195_calcinosis1.26185722
49MP0008872_abnormal_physiological_respon1.24748502
50MP0000372_irregular_coat_pigmentation1.23491594
51MP0005623_abnormal_meninges_morphology1.22149179
52MP0009379_abnormal_foot_pigmentation1.18461891
53MP0001440_abnormal_grooming_behavior1.17871468
54MP0009745_abnormal_behavioral_response1.16297600
55MP0001666_abnormal_nutrient_absorption1.16164701
56MP0002653_abnormal_ependyma_morphology1.14479100
57MP0003880_abnormal_central_pattern1.13666974
58MP0003936_abnormal_reproductive_system1.12839430
59MP0009046_muscle_twitch1.12654535
60MP0001968_abnormal_touch/_nociception1.11189768
61MP0001485_abnormal_pinna_reflex1.11064196
62MP0000230_abnormal_systemic_arterial1.11063998
63MP0002163_abnormal_gland_morphology1.10049445
64MP0002139_abnormal_hepatobiliary_system1.08822434
65MP0000647_abnormal_sebaceous_gland1.07937403
66MP0002161_abnormal_fertility/fecundity1.07311299
67MP0000462_abnormal_digestive_system1.04524468
68MP0000778_abnormal_nervous_system1.03827885
69MP0001764_abnormal_homeostasis0.99699649
70MP0008875_abnormal_xenobiotic_pharmacok0.95273871
71MP0005167_abnormal_blood-brain_barrier0.94777429
72MP0002090_abnormal_vision0.93723357
73MP0002067_abnormal_sensory_capabilities0.92769910
74MP0003806_abnormal_nucleotide_metabolis0.92259451
75MP0008789_abnormal_olfactory_epithelium0.91123462
76MP0002557_abnormal_social/conspecific_i0.87282134
77MP0003121_genomic_imprinting0.86426196
78MP0002184_abnormal_innervation0.86228154
79MP0002102_abnormal_ear_morphology0.84131697
80MP0003868_abnormal_feces_composition0.83646726
81MP0005499_abnormal_olfactory_system0.82474118
82MP0005394_taste/olfaction_phenotype0.82474118
83MP0002234_abnormal_pharynx_morphology0.79899801
84MP0004885_abnormal_endolymph0.77137867
85MP0001486_abnormal_startle_reflex0.76442917
86MP0003866_abnormal_defecation0.75705669
87MP0001286_abnormal_eye_development0.75000442
88MP0003638_abnormal_response/metabolism_0.74757313
89MP0003937_abnormal_limbs/digits/tail_de0.73110107
90MP0004145_abnormal_muscle_electrophysio0.72616174
91MP0000470_abnormal_stomach_morphology0.69247002
92MP0000026_abnormal_inner_ear0.68513134
93MP0001293_anophthalmia0.67607334
94MP0003959_abnormal_lean_body0.67419996
95MP0008961_abnormal_basal_metabolism0.66819343
96MP0002229_neurodegeneration0.66504432
97MP0003077_abnormal_cell_cycle0.66051292
98MP0009697_abnormal_copulation0.66012160
99MP0002233_abnormal_nose_morphology0.65109608
100MP0009384_cardiac_valve_regurgitation0.64837352

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.23965005
2Oligodactyly (hands) (HP:0001180)4.11992071
3Premature ovarian failure (HP:0008209)4.00487303
4Chromsome breakage (HP:0040012)4.00094021
5Median cleft lip (HP:0000161)3.95674814
6Pancreatic fibrosis (HP:0100732)3.66032980
7Lipid accumulation in hepatocytes (HP:0006561)3.32528525
8Abnormality of alanine metabolism (HP:0010916)3.30585788
9Hyperalaninemia (HP:0003348)3.30585788
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.30585788
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.28784154
12Abnormality of chromosome stability (HP:0003220)3.19612429
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15593576
14Oligodactyly (HP:0012165)3.06238262
15Meckel diverticulum (HP:0002245)3.03571876
16Aplasia/Hypoplasia of the tibia (HP:0005772)3.02155622
17Short tibia (HP:0005736)3.00844412
18Increased hepatocellular lipid droplets (HP:0006565)2.97685120
19Exertional dyspnea (HP:0002875)2.95150385
20Abnormality of the ileum (HP:0001549)2.90648220
21Colon cancer (HP:0003003)2.84748872
22Microglossia (HP:0000171)2.84574261
23Aplasia/Hypoplasia of the tongue (HP:0010295)2.79224886
24Abnormality of the preputium (HP:0100587)2.75184085
25Birth length less than 3rd percentile (HP:0003561)2.75155267
26Medial flaring of the eyebrow (HP:0010747)2.73445617
27Abnormal number of incisors (HP:0011064)2.70535487
28Congenital sensorineural hearing impairment (HP:0008527)2.69943087
29Adrenal hypoplasia (HP:0000835)2.68132470
30Abdominal situs inversus (HP:0003363)2.66421835
31Abnormality of abdominal situs (HP:0011620)2.66421835
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62498725
33Congenital primary aphakia (HP:0007707)2.52519187
34Renal Fanconi syndrome (HP:0001994)2.51118265
35Facial cleft (HP:0002006)2.50888052
36Ectopic kidney (HP:0000086)2.50886328
37Gait imbalance (HP:0002141)2.50253459
38Atonic seizures (HP:0010819)2.48333220
39Abnormality of the nasal septum (HP:0000419)2.47659065
40Abnormality of male internal genitalia (HP:0000022)2.47225627
41Genital tract atresia (HP:0001827)2.46502617
42Abnormality of the labia minora (HP:0012880)2.45099871
43Amelogenesis imperfecta (HP:0000705)2.42303872
44Tetany (HP:0001281)2.42203115
45Clubbing of toes (HP:0100760)2.41040608
46Focal motor seizures (HP:0011153)2.40553763
47Acute encephalopathy (HP:0006846)2.40019466
48True hermaphroditism (HP:0010459)2.36926130
49Acute necrotizing encephalopathy (HP:0006965)2.36083579
50Hypoplasia of the uterus (HP:0000013)2.36016312
51Metaphyseal dysplasia (HP:0100255)2.35122071
52Small intestinal stenosis (HP:0012848)2.32372368
53Duodenal stenosis (HP:0100867)2.32372368
54Mitochondrial inheritance (HP:0001427)2.26411437
55Absent thumb (HP:0009777)2.24016456
56Nephrogenic diabetes insipidus (HP:0009806)2.23941212
57Preaxial hand polydactyly (HP:0001177)2.21449172
58Increased CSF lactate (HP:0002490)2.19927342
59Abnormal auditory evoked potentials (HP:0006958)2.17099350
60Abnormality of the prostate (HP:0008775)2.14105176
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12619124
62Sclerocornea (HP:0000647)2.11807020
63Male infertility (HP:0003251)2.11384130
64Hyperglycinuria (HP:0003108)2.10987769
65Abnormality of the duodenum (HP:0002246)2.10976643
66Abnormality of the renal cortex (HP:0011035)2.09339456
67Abnormality of midbrain morphology (HP:0002418)2.08911469
68Molar tooth sign on MRI (HP:0002419)2.08911469
69Spastic diplegia (HP:0001264)2.08723648
70Aplasia/hypoplasia of the uterus (HP:0008684)2.08218438
71Poor coordination (HP:0002370)2.06037772
72Pancreatic cysts (HP:0001737)2.05823724
73Impulsivity (HP:0100710)2.05112308
74Maternal diabetes (HP:0009800)2.04571746
75Abnormality of renal resorption (HP:0011038)2.04423164
76Hydroxyprolinuria (HP:0003080)2.03963144
77Abnormality of proline metabolism (HP:0010907)2.03963144
78Glycosuria (HP:0003076)2.03548581
79Abnormality of urine glucose concentration (HP:0011016)2.03548581
80Rectal prolapse (HP:0002035)2.03291011
81Abnormal pancreas size (HP:0012094)2.02233508
82Short thumb (HP:0009778)2.00967032
83Optic nerve hypoplasia (HP:0000609)1.99774278
84Postaxial foot polydactyly (HP:0001830)1.98536939
85Horseshoe kidney (HP:0000085)1.96295033
86Abnormality of the carotid arteries (HP:0005344)1.96028847
87Partial agenesis of the corpus callosum (HP:0001338)1.95135179
88High anterior hairline (HP:0009890)1.94534190
89Azoospermia (HP:0000027)1.94284801
90Abnormality of dental color (HP:0011073)1.94078581
91Disproportionate short-trunk short stature (HP:0003521)1.91580411
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88777950
93Anhidrosis (HP:0000970)1.88606669
94Nephronophthisis (HP:0000090)1.87591166
95Hyperphosphatemia (HP:0002905)1.87545837
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87073061
97Hypoplastic iliac wings (HP:0002866)1.86872436
98Vaginal atresia (HP:0000148)1.85536459
99Abnormal mitochondria in muscle tissue (HP:0008316)1.85422475
100Constricted visual fields (HP:0001133)1.85347546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.92355678
2ZAK4.86234951
3VRK13.75785148
4STK163.62863098
5TAOK33.10832405
6PLK43.08258756
7INSRR3.00490304
8TNIK2.94916129
9BMPR1B2.24736132
10AURKA2.16577015
11NUAK12.12732265
12STK391.96208986
13CDK121.75011397
14VRK21.69941842
15CDC71.58043114
16CAMK1D1.56831505
17CAMKK21.54767742
18MAP2K21.37965575
19LMTK21.33326531
20WNK41.22147117
21PLK21.21676475
22MAPK151.21172458
23FRK1.20907593
24OXSR11.20561499
25RPS6KA51.19637075
26PBK1.19603711
27BUB11.12202900
28TEC1.12174568
29GRK11.11851514
30CDK191.11675294
31STK38L1.11536768
32ACVR1B1.10891596
33PTK2B1.08504967
34CHEK21.08041911
35AURKB1.02442402
36MAPK131.00682394
37MAP2K31.00256077
38TSSK60.98837413
39PIK3CA0.94001965
40MAP3K40.90888051
41PLK10.89975228
42ICK0.88656267
43ADRBK20.88169108
44CAMK1G0.81288923
45TTK0.79892505
46PKN10.79604024
47EPHA40.79310682
48PNCK0.78441760
49PRKG20.77671617
50GRK50.73658962
51PLK30.72600140
52WNK10.71785680
53NLK0.71189343
54WNK30.69551161
55CAMK40.67199948
56GRK70.63598300
57MAP2K70.61162032
58PRKD30.61060062
59PDK20.60036800
60MAP4K20.59197638
61ATR0.57328775
62CSNK1G10.56392290
63PRKCQ0.55887733
64IRAK10.55532409
65PINK10.54639087
66TGFBR20.54025491
67ATM0.51893918
68MAP3K60.50649454
69CSNK1E0.49506280
70TYRO30.48702663
71WEE10.47741375
72CSNK1G20.47730078
73CDK70.46135207
74PRKACA0.44788871
75SRPK10.44445740
76TIE10.41852636
77AKT20.41655655
78CAMK2A0.39596647
79TAF10.39006590
80PRKCE0.38490524
81BRD40.37799614
82IGF1R0.36973741
83CHEK10.36469725
84PRKACB0.36072145
85MAP2K60.33827215
86ADRBK10.33012178
87PRKAA10.32992944
88CSNK1D0.31066865
89MAP2K40.31034473
90EIF2AK20.30891543
91CAMKK10.30661851
92CAMK10.29037292
93BRAF0.28977155
94DAPK30.28808784
95MAP3K50.28665213
96CSNK2A10.27737736
97TRIM280.27277441
98CSNK1G30.27000007
99MAP3K30.26861391
100PIM10.26035572

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.20583908
2Systemic lupus erythematosus_Homo sapiens_hsa053223.70983418
3Homologous recombination_Homo sapiens_hsa034403.54210799
4Fanconi anemia pathway_Homo sapiens_hsa034602.91037310
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.88066537
6Mismatch repair_Homo sapiens_hsa034302.81622148
7Alcoholism_Homo sapiens_hsa050342.78073765
8Sulfur metabolism_Homo sapiens_hsa009202.36224872
9Basal transcription factors_Homo sapiens_hsa030222.26950178
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16678936
11Dorso-ventral axis formation_Homo sapiens_hsa043202.02176477
12Non-homologous end-joining_Homo sapiens_hsa034501.99513455
13Linoleic acid metabolism_Homo sapiens_hsa005911.91524844
14Chemical carcinogenesis_Homo sapiens_hsa052041.85043110
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.74486303
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69715914
17Fatty acid biosynthesis_Homo sapiens_hsa000611.68391519
18DNA replication_Homo sapiens_hsa030301.62268522
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57010209
20Tryptophan metabolism_Homo sapiens_hsa003801.52023998
21Phototransduction_Homo sapiens_hsa047441.47059252
22Protein export_Homo sapiens_hsa030601.40456877
23Nicotine addiction_Homo sapiens_hsa050331.39754645
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38854057
25Bile secretion_Homo sapiens_hsa049761.35289053
26Butanoate metabolism_Homo sapiens_hsa006501.34854230
27RNA transport_Homo sapiens_hsa030131.32664835
28Retinol metabolism_Homo sapiens_hsa008301.32523501
29RNA polymerase_Homo sapiens_hsa030201.28127077
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23755502
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23190442
32RNA degradation_Homo sapiens_hsa030181.19914963
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13674027
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06802417
35GABAergic synapse_Homo sapiens_hsa047271.06048557
36Steroid biosynthesis_Homo sapiens_hsa001001.05083031
37Ribosome_Homo sapiens_hsa030101.04042204
38Oxidative phosphorylation_Homo sapiens_hsa001901.03064165
39Parkinsons disease_Homo sapiens_hsa050121.00604891
40Huntingtons disease_Homo sapiens_hsa050160.97575698
41Ether lipid metabolism_Homo sapiens_hsa005650.97303209
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91151139
43Nucleotide excision repair_Homo sapiens_hsa034200.90546046
44Morphine addiction_Homo sapiens_hsa050320.90398774
45Fat digestion and absorption_Homo sapiens_hsa049750.89548053
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.89515439
47Purine metabolism_Homo sapiens_hsa002300.88769678
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.86157420
49Serotonergic synapse_Homo sapiens_hsa047260.86073073
50Nitrogen metabolism_Homo sapiens_hsa009100.84652988
51p53 signaling pathway_Homo sapiens_hsa041150.81897247
52Pyrimidine metabolism_Homo sapiens_hsa002400.80502217
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.79164112
54Olfactory transduction_Homo sapiens_hsa047400.78519573
55Regulation of autophagy_Homo sapiens_hsa041400.78106883
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77972849
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76643162
58Vitamin digestion and absorption_Homo sapiens_hsa049770.76239508
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74249937
60Hedgehog signaling pathway_Homo sapiens_hsa043400.74066217
61Viral carcinogenesis_Homo sapiens_hsa052030.69607888
62Taste transduction_Homo sapiens_hsa047420.69443582
63Collecting duct acid secretion_Homo sapiens_hsa049660.68551025
64Arachidonic acid metabolism_Homo sapiens_hsa005900.68047725
65Base excision repair_Homo sapiens_hsa034100.67635214
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64580480
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63238549
68Oocyte meiosis_Homo sapiens_hsa041140.61003993
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60653981
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59929879
71Insulin secretion_Homo sapiens_hsa049110.59478251
72Caffeine metabolism_Homo sapiens_hsa002320.58896176
73Ovarian steroidogenesis_Homo sapiens_hsa049130.58314451
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55143039
75Selenocompound metabolism_Homo sapiens_hsa004500.54592419
76Fatty acid metabolism_Homo sapiens_hsa012120.52722245
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52046090
78Cocaine addiction_Homo sapiens_hsa050300.51867245
79One carbon pool by folate_Homo sapiens_hsa006700.51629667
80Spliceosome_Homo sapiens_hsa030400.50904763
81Lysine degradation_Homo sapiens_hsa003100.50178327
82Glutathione metabolism_Homo sapiens_hsa004800.50169533
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48840566
84mRNA surveillance pathway_Homo sapiens_hsa030150.47410184
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45497174
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42301093
87cAMP signaling pathway_Homo sapiens_hsa040240.41580310
88Metabolic pathways_Homo sapiens_hsa011000.40710228
89Circadian entrainment_Homo sapiens_hsa047130.40361282
90Cardiac muscle contraction_Homo sapiens_hsa042600.39196530
91Arginine biosynthesis_Homo sapiens_hsa002200.38446693
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38301098
93Propanoate metabolism_Homo sapiens_hsa006400.34435072
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33804311
95Dopaminergic synapse_Homo sapiens_hsa047280.33089741
96Glutamatergic synapse_Homo sapiens_hsa047240.31921239
97Calcium signaling pathway_Homo sapiens_hsa040200.27396615
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27084963
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.27012661
100Tyrosine metabolism_Homo sapiens_hsa003500.26748004

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »