CCT7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of dendrite morphogenesis (GO:0050774)9.95213254
2Rap protein signal transduction (GO:0032486)8.97450780
3protein K11-linked deubiquitination (GO:0035871)6.52896512
4keratinocyte development (GO:0003334)6.16430963
5positive regulation of protein autophosphorylation (GO:0031954)5.98380949
6negative regulation of dendrite development (GO:2000171)5.80961964
7lactate metabolic process (GO:0006089)5.60747318
8pseudouridine synthesis (GO:0001522)5.42963274
9negative regulation of calcium ion transport into cytosol (GO:0010523)5.34651608
10regulation of RIG-I signaling pathway (GO:0039535)5.31165283
11negative regulation of neurological system process (GO:0031645)5.22661866
12single strand break repair (GO:0000012)5.18227924
13amine catabolic process (GO:0009310)4.87716959
14cellular biogenic amine catabolic process (GO:0042402)4.87716959
15polyamine biosynthetic process (GO:0006596)4.86595324
16regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.79068137
17otic vesicle formation (GO:0030916)4.73827406
18negative regulation of JUN kinase activity (GO:0043508)4.45116219
19trophectodermal cell differentiation (GO:0001829)4.43348305
20inositol phosphate-mediated signaling (GO:0048016)4.26203270
21neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.21288010
22nephron tubule formation (GO:0072079)4.19043446
23chemosensory behavior (GO:0007635)4.11113522
24cellular biogenic amine biosynthetic process (GO:0042401)4.07760969
25negative regulation of bone resorption (GO:0045779)4.07666978
26negative regulation of epithelial to mesenchymal transition (GO:0010719)3.99874902
27regulation of dendritic spine morphogenesis (GO:0061001)3.96316313
28amine biosynthetic process (GO:0009309)3.92286948
29detection of temperature stimulus involved in sensory perception (GO:0050961)3.90880005
30detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.90880005
31heart valve morphogenesis (GO:0003179)3.89322569
32G-protein coupled receptor internalization (GO:0002031)3.85184373
33phasic smooth muscle contraction (GO:0014821)3.77370170
34negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.76924079
35pyrimidine dimer repair (GO:0006290)3.75945500
36ER overload response (GO:0006983)3.72826137
37artery smooth muscle contraction (GO:0014824)3.65228494
38regulation of relaxation of muscle (GO:1901077)3.63111865
39negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.60245950
40limb bud formation (GO:0060174)3.56852296
41protein K48-linked deubiquitination (GO:0071108)3.54544640
42DNA catabolic process, exonucleolytic (GO:0000738)3.52132989
43negative regulation of smooth muscle cell differentiation (GO:0051151)3.50621158
44eye photoreceptor cell differentiation (GO:0001754)3.45490448
45photoreceptor cell differentiation (GO:0046530)3.45490448
46DNA double-strand break processing (GO:0000729)3.44565976
47positive regulation of male gonad development (GO:2000020)3.43933262
48positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.37350874
49positive regulation of cell size (GO:0045793)3.30311804
50regulation of protein autophosphorylation (GO:0031952)3.27359406
51ovulation from ovarian follicle (GO:0001542)3.23026010
52negative regulation of DNA-templated transcription, elongation (GO:0032785)3.20401285
53regulation of T cell receptor signaling pathway (GO:0050856)3.18689708
54negative regulation of myoblast differentiation (GO:0045662)3.17570213
55regulation of helicase activity (GO:0051095)3.15168626
56negative regulation of bone remodeling (GO:0046851)3.15003099
57positive regulation of glycoprotein biosynthetic process (GO:0010560)3.12462125
58S-adenosylmethionine metabolic process (GO:0046500)3.12331661
59polyamine metabolic process (GO:0006595)3.12317635
60regulation of male gonad development (GO:2000018)3.11468655
61detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.07986207
62NIK/NF-kappaB signaling (GO:0038061)3.07969156
63cardiac epithelial to mesenchymal transition (GO:0060317)3.07313940
64DNA deamination (GO:0045006)3.06386101
65tonic smooth muscle contraction (GO:0014820)3.06161239
66positive regulation of extracellular matrix organization (GO:1903055)2.99863479
67negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.99572860
68negative regulation of stem cell differentiation (GO:2000737)2.91982733
69notochord development (GO:0030903)2.90755972
70calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.89756437
71negative regulation of smooth muscle contraction (GO:0045986)2.88999742
72piRNA metabolic process (GO:0034587)2.82628549
73proteasome assembly (GO:0043248)2.82303312
74DNA damage response, detection of DNA damage (GO:0042769)2.80021822
75myoblast migration (GO:0051451)2.78575414
76negative regulation of tissue remodeling (GO:0034104)2.76120843
77rRNA methylation (GO:0031167)2.73650286
78peristalsis (GO:0030432)2.73126015
79regulation of hexokinase activity (GO:1903299)2.72732178
80regulation of glucokinase activity (GO:0033131)2.72732178
81cAMP catabolic process (GO:0006198)2.71769110
82protein K63-linked deubiquitination (GO:0070536)2.71726878
83positive regulation of cytokinesis (GO:0032467)2.71237094
84endothelial cell proliferation (GO:0001935)2.71135902
85protein localization to microtubule (GO:0035372)2.70792769
86regulation of cardioblast differentiation (GO:0051890)2.70182977
87neural crest cell development (GO:0014032)2.69143487
88positive regulation of histone methylation (GO:0031062)2.68885990
89protein maturation by protein folding (GO:0022417)2.67959098
90positive regulation of macrophage differentiation (GO:0045651)2.66937894
91negative regulation of signal transduction by p53 class mediator (GO:1901797)2.66633547
92negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.66269349
93male sex determination (GO:0030238)2.63576513
94detection of temperature stimulus (GO:0016048)2.63546476
95SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.63181248
96interferon-gamma production (GO:0032609)2.62068399
97cytokine biosynthetic process (GO:0042089)2.59375094
98negative regulation of T cell receptor signaling pathway (GO:0050860)2.57849501
99regulation of memory T cell differentiation (GO:0043380)2.56992477
100sensory perception of smell (GO:0007608)2.55791496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.73151726
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.71609133
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.21166144
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.20692877
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.10223286
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96173230
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70048642
8FUS_26573619_Chip-Seq_HEK293_Human2.63245308
9ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.51759578
10IGF1R_20145208_ChIP-Seq_DFB_Human2.49525083
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46678982
12PKCTHETA_26484144_Chip-Seq_BREAST_Human2.34044281
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.21471533
14CJUN_26792858_Chip-Seq_BT549_Human2.13695218
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10305814
16ZNF274_21170338_ChIP-Seq_K562_Hela2.02983139
17EWS_26573619_Chip-Seq_HEK293_Human1.94124344
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93338903
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84130582
20VDR_22108803_ChIP-Seq_LS180_Human1.83772177
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.70571354
22CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.68698699
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.68184982
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.67776444
25PHF8_20622853_ChIP-Seq_HELA_Human1.65041088
26ER_23166858_ChIP-Seq_MCF-7_Human1.62170840
27RXR_22108803_ChIP-Seq_LS180_Human1.60660028
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60374249
29P300_19829295_ChIP-Seq_ESCs_Human1.60351684
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.60084801
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56136730
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54444928
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54155574
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54113393
35CDX2_22108803_ChIP-Seq_LS180_Human1.54037642
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53262755
37AR_21572438_ChIP-Seq_LNCaP_Human1.53043349
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52803110
39GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.51503386
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.48601521
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.47881470
42FOXA1_21572438_ChIP-Seq_LNCaP_Human1.47425041
43GATA6_21074721_ChIP-Seq_CACO-2_Human1.46081915
44RBPJ_21746931_ChIP-Seq_IB4_Human1.46049590
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.45858452
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.44315733
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44092295
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.43814989
49GATA3_26560356_Chip-Seq_TH2_Human1.41857010
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40657469
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40014759
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40014759
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38402800
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37614570
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.37515627
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37286735
57RNF2_27304074_Chip-Seq_NSC_Mouse1.35160779
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33389830
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.33063556
60GATA4_25053715_ChIP-Seq_YYC3_Human1.29313814
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.27896705
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27628370
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27455994
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.26859255
65SMRT_27268052_Chip-Seq_Bcells_Human1.26282950
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25296837
67TBL1_22424771_ChIP-Seq_293T_Human1.25073501
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24661215
69HOXB7_26014856_ChIP-Seq_BT474_Human1.24398486
70GATA6_25053715_ChIP-Seq_YYC3_Human1.24178433
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.23546980
72NFYB_21822215_ChIP-Seq_K562_Human1.23541860
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.22802080
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22509221
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.22509221
76IRF1_19129219_ChIP-ChIP_H3396_Human1.22404496
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19870069
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19083555
79GATA1_22025678_ChIP-Seq_K562_Human1.18547710
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18122297
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17835575
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.17051184
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14386975
84NANOG_19829295_ChIP-Seq_ESCs_Human1.13701856
85SOX2_19829295_ChIP-Seq_ESCs_Human1.13701856
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12572085
87TAF15_26573619_Chip-Seq_HEK293_Human1.12430550
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11936223
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11414610
90ELK1_19687146_ChIP-ChIP_HELA_Human1.11283484
91ETV1_20927104_ChIP-Seq_GIST48_Human1.10008672
92BCAT_22108803_ChIP-Seq_LS180_Human1.09325710
93BP1_19119308_ChIP-ChIP_Hs578T_Human1.09234685
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09196906
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06348741
96CBP_21632823_ChIP-Seq_H3396_Human1.05909007
97VDR_23849224_ChIP-Seq_CD4+_Human1.05303714
98TCF4_22108803_ChIP-Seq_LS180_Human1.04924867
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02429216
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.02045403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.16809415
2MP0008057_abnormal_DNA_replication5.13386384
3MP0000569_abnormal_digit_pigmentation3.32156055
4MP0006276_abnormal_autonomic_nervous2.98570808
5MP0008007_abnormal_cellular_replicative2.46903047
6MP0008058_abnormal_DNA_repair2.39378217
7MP0005167_abnormal_blood-brain_barrier2.33980013
8MP0001873_stomach_inflammation2.19293117
9MP0002735_abnormal_chemical_nociception2.17783246
10MP0001853_heart_inflammation2.10606724
11MP0003123_paternal_imprinting2.09225986
12MP0002138_abnormal_hepatobiliary_system2.07595559
13MP0003718_maternal_effect1.97608590
14MP0002282_abnormal_trachea_morphology1.93319603
15MP0006036_abnormal_mitochondrial_physio1.85498900
16MP0005645_abnormal_hypothalamus_physiol1.81232889
17MP0001542_abnormal_bone_strength1.78901924
18MP0002909_abnormal_adrenal_gland1.78144252
19MP0001765_abnormal_ion_homeostasis1.71823704
20MP0000613_abnormal_salivary_gland1.68818513
21MP0001529_abnormal_vocalization1.65506130
22MP0008872_abnormal_physiological_respon1.64241489
23MP0005174_abnormal_tail_pigmentation1.63722311
24MP0008877_abnormal_DNA_methylation1.62416064
25MP0001485_abnormal_pinna_reflex1.57335638
26MP0002638_abnormal_pupillary_reflex1.56681038
27MP0009840_abnormal_foam_cell1.50499449
28MP0005636_abnormal_mineral_homeostasis1.47598977
29MP0003786_premature_aging1.47450144
30MP0003567_abnormal_fetal_cardiomyocyte1.46307660
31MP0004019_abnormal_vitamin_homeostasis1.44655318
32MP0002234_abnormal_pharynx_morphology1.42674928
33MP0003724_increased_susceptibility_to1.39064766
34MP0005671_abnormal_response_to1.38394616
35MP0003693_abnormal_embryo_hatching1.36363732
36MP0006072_abnormal_retinal_apoptosis1.34127685
37MP0005395_other_phenotype1.29857374
38MP0002148_abnormal_hypersensitivity_rea1.28228457
39MP0009046_muscle_twitch1.26327802
40MP0005075_abnormal_melanosome_morpholog1.22936530
41MP0002233_abnormal_nose_morphology1.22710088
42MP0006138_congestive_heart_failure1.22377569
43MP0001501_abnormal_sleep_pattern1.21875392
44MP0000372_irregular_coat_pigmentation1.20977475
45MP0008789_abnormal_olfactory_epithelium1.20030249
46MP0003195_calcinosis1.19510039
47MP0005410_abnormal_fertilization1.12084501
48MP0000015_abnormal_ear_pigmentation1.09977859
49MP0005083_abnormal_biliary_tract1.09793833
50MP0002693_abnormal_pancreas_physiology1.09738703
51MP0004147_increased_porphyrin_level1.08017799
52MP0002166_altered_tumor_susceptibility1.04698737
53MP0008995_early_reproductive_senescence1.03730672
54MP0003828_pulmonary_edema1.03606102
55MP0009643_abnormal_urine_homeostasis1.01634803
56MP0004484_altered_response_of1.01271354
57MP0000537_abnormal_urethra_morphology0.99422299
58MP0008875_abnormal_xenobiotic_pharmacok0.96420063
59MP0004782_abnormal_surfactant_physiolog0.95726561
60MP0004264_abnormal_extraembryonic_tissu0.95293947
61MP0003943_abnormal_hepatobiliary_system0.94851637
62MP0002972_abnormal_cardiac_muscle0.94227215
63MP0002168_other_aberrant_phenotype0.93169418
64MP0005332_abnormal_amino_acid0.92280471
65MP0000538_abnormal_urinary_bladder0.90684167
66MP0005647_abnormal_sex_gland0.89945235
67MP0003303_peritoneal_inflammation0.89494624
68MP0005551_abnormal_eye_electrophysiolog0.87533883
69MP0005620_abnormal_muscle_contractility0.87172118
70MP0003950_abnormal_plasma_membrane0.84584524
71MP0005379_endocrine/exocrine_gland_phen0.84497649
72MP0004270_analgesia0.83741702
73MP0001727_abnormal_embryo_implantation0.83547848
74MP0001666_abnormal_nutrient_absorption0.83031363
75MP0003045_fibrosis0.81314031
76MP0009764_decreased_sensitivity_to0.81119447
77MP0001944_abnormal_pancreas_morphology0.80040129
78MP0009278_abnormal_bone_marrow0.79755381
79MP0010352_gastrointestinal_tract_polyps0.79142914
80MP0001800_abnormal_humoral_immune0.77130992
81MP0003866_abnormal_defecation0.76983960
82MP0002254_reproductive_system_inflammat0.76880203
83MP0000049_abnormal_middle_ear0.76414345
84MP0000013_abnormal_adipose_tissue0.74712422
85MP0005253_abnormal_eye_physiology0.74597033
86MP0002006_tumorigenesis0.73012983
87MP0002102_abnormal_ear_morphology0.70799723
88MP0005000_abnormal_immune_tolerance0.70221123
89MP0002796_impaired_skin_barrier0.69585368
90MP0005084_abnormal_gallbladder_morpholo0.69260600
91MP0002277_abnormal_respiratory_mucosa0.69095989
92MP0002295_abnormal_pulmonary_circulatio0.68314276
93MP0000230_abnormal_systemic_arterial0.67652775
94MP0004085_abnormal_heartbeat0.67540712
95MP0002132_abnormal_respiratory_system0.67114754
96MP0003936_abnormal_reproductive_system0.65363930
97MP0005397_hematopoietic_system_phenotyp0.65326082
98MP0001545_abnormal_hematopoietic_system0.65326082
99MP0000639_abnormal_adrenal_gland0.63876533
100MP0002249_abnormal_larynx_morphology0.63509693

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)6.01942363
2Follicular hyperkeratosis (HP:0007502)5.57036987
3True hermaphroditism (HP:0010459)5.15700883
411 pairs of ribs (HP:0000878)4.95913232
5Abnormal sex determination (HP:0012244)4.79885422
6Sex reversal (HP:0012245)4.79885422
7Congenital stationary night blindness (HP:0007642)4.16370571
8Molar tooth sign on MRI (HP:0002419)3.86932786
9Abnormality of midbrain morphology (HP:0002418)3.86932786
10Sensory axonal neuropathy (HP:0003390)3.72816101
11Elevated erythrocyte sedimentation rate (HP:0003565)3.51469541
12Abnormal biliary tract physiology (HP:0012439)3.50092691
13Bile duct proliferation (HP:0001408)3.50092691
14Abnormality of dental color (HP:0011073)3.49203327
15Nephronophthisis (HP:0000090)3.44220967
16Genetic anticipation (HP:0003743)3.42926999
17Duplicated collecting system (HP:0000081)3.37916392
18Impaired smooth pursuit (HP:0007772)3.33409442
19Vacuolated lymphocytes (HP:0001922)3.32557337
20Atonic seizures (HP:0010819)3.27567295
21Abnormality of the renal collecting system (HP:0004742)3.25211301
22Ureteral duplication (HP:0000073)3.16699467
23Pancreatic cysts (HP:0001737)3.06719732
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.05572002
25Sparse eyelashes (HP:0000653)2.96924850
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92991055
27Stomach cancer (HP:0012126)2.91480853
28Stenosis of the external auditory canal (HP:0000402)2.85677664
29Stomatitis (HP:0010280)2.81113912
30Pancreatic fibrosis (HP:0100732)2.80709745
31Chromsome breakage (HP:0040012)2.73644801
32Slow saccadic eye movements (HP:0000514)2.66661811
33Reticulocytopenia (HP:0001896)2.59505708
34Hypokinesia (HP:0002375)2.57296506
35Glossoptosis (HP:0000162)2.56126133
36Missing ribs (HP:0000921)2.55882602
37Abnormality of the renal medulla (HP:0100957)2.54970705
38Congenital, generalized hypertrichosis (HP:0004540)2.49614960
39Blepharitis (HP:0000498)2.44341707
40Bifid tongue (HP:0010297)2.43628863
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42256298
42Vascular calcification (HP:0004934)2.39233418
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.38132665
44Vertebral hypoplasia (HP:0008417)2.38132665
45Scanning speech (HP:0002168)2.37147406
46Abnormality of pyrimidine metabolism (HP:0004353)2.36413555
47Increased cerebral lipofuscin (HP:0011813)2.31329399
48Parakeratosis (HP:0001036)2.30351945
49Testicular atrophy (HP:0000029)2.29695242
50Clubbing of toes (HP:0100760)2.29071978
51Microretrognathia (HP:0000308)2.26498120
52Abnormality of DNA repair (HP:0003254)2.24918637
53Male pseudohermaphroditism (HP:0000037)2.24356586
54Abnormality of ocular smooth pursuit (HP:0000617)2.24105342
55Optic nerve coloboma (HP:0000588)2.24102287
56Erythema (HP:0010783)2.21743035
57Abolished electroretinogram (ERG) (HP:0000550)2.20022475
58Abnormality of saccadic eye movements (HP:0000570)2.19554136
59Hypoproteinemia (HP:0003075)2.18563839
60Furrowed tongue (HP:0000221)2.15479821
61Ectropion (HP:0000656)2.13298733
62Ectopic kidney (HP:0000086)2.12095811
63Viral hepatitis (HP:0006562)2.10552281
64Panhypogammaglobulinemia (HP:0003139)2.07186442
65Neonatal short-limb short stature (HP:0008921)2.06901464
66Subacute progressive viral hepatitis (HP:0006572)2.06634900
67Urinary bladder sphincter dysfunction (HP:0002839)2.06178337
68Febrile seizures (HP:0002373)2.03252811
69Cardiovascular calcification (HP:0011915)2.01808637
70Exercise-induced muscle cramps (HP:0003710)1.97736211
71Dysmetric saccades (HP:0000641)1.96210636
72Hypoglycemic coma (HP:0001325)1.95181952
73Fibular hypoplasia (HP:0003038)1.92082149
74Hemiparesis (HP:0001269)1.91379144
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.89622158
76Alveolar cell carcinoma (HP:0006519)1.88580236
77Abnormality of male internal genitalia (HP:0000022)1.87266215
78Mesangial abnormality (HP:0001966)1.84957790
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.84821214
80Keratitis (HP:0000491)1.83306250
81Cystic liver disease (HP:0006706)1.83107784
82Progressive macrocephaly (HP:0004481)1.82812954
83Poor speech (HP:0002465)1.82444404
84Attenuation of retinal blood vessels (HP:0007843)1.81745127
85Anhidrosis (HP:0000970)1.81048005
86Breast carcinoma (HP:0003002)1.80973772
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.80245147
88Respiratory distress (HP:0002098)1.79012794
89Limb dystonia (HP:0002451)1.77994278
90Gaze-evoked nystagmus (HP:0000640)1.77908106
91Abnormality of the preputium (HP:0100587)1.76413252
92Decreased central vision (HP:0007663)1.76279094
93Hypoplasia of the pons (HP:0012110)1.75990082
94Optic disc pallor (HP:0000543)1.75367868
95IgG deficiency (HP:0004315)1.74613011
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.72298853
97Asplenia (HP:0001746)1.70888649
98Global brain atrophy (HP:0002283)1.69440139
99Micronodular cirrhosis (HP:0001413)1.68744234
100Absent thumb (HP:0009777)1.68445112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST48.54499810
2GRK16.35247382
3EPHA23.14552506
4ADRBK22.71374319
5TIE12.41076720
6MAP3K32.39408038
7BRSK22.27329030
8WEE11.79021261
9TRIM281.73526046
10BUB11.71968917
11STK101.69906793
12NUAK11.65331378
13DYRK31.63797901
14TLK11.62535365
15TEC1.61325167
16CSNK1A1L1.59002289
17STK31.55788431
18CSNK1G31.53009297
19CASK1.49880741
20IKBKB1.45219769
21BMPR21.41062032
22STK381.36272287
23DYRK1A1.31988168
24ZAK1.31729499
25TSSK61.27827741
26EIF2AK31.27627342
27CSNK1G11.19582453
28OXSR11.17453124
29TAOK11.08817837
30FRK1.07242864
31ITK1.05739182
32CSNK1G21.02274199
33PRKCI1.02023470
34TNIK1.01891481
35MAP3K140.93356605
36BMPR1B0.89774295
37MAP4K20.87635380
38SRPK10.86401253
39STK390.81675230
40MKNK20.80875873
41EIF2AK10.80036437
42TBK10.70574803
43PTK2B0.70524493
44LATS10.70340546
45ADRBK10.69444005
46TAOK30.68347246
47NME20.67433036
48TAOK20.67241856
49BCR0.65550118
50PASK0.61471401
51BRSK10.61108166
52CSNK1A10.59549372
53CLK10.57466978
54VRK20.56453930
55TESK20.56036844
56MAP3K10.54040078
57MKNK10.53755848
58FGFR30.52700601
59DAPK20.52479489
60PHKG20.50319523
61PHKG10.50319523
62CCNB10.49785643
63SIK30.49210029
64VRK10.48038552
65CHUK0.46892323
66NEK10.45227590
67BTK0.41453389
68PRKCG0.41374742
69PIK3CA0.41243929
70PLK30.41022049
71INSRR0.39865625
72PLK10.39202911
73PRKCE0.38700455
74ROCK10.35938633
75FER0.35469060
76GRK50.35104907
77MATK0.34440677
78PBK0.33894534
79PAK10.33693521
80EGFR0.32192589
81EIF2AK20.30841897
82PRKCQ0.30745843
83DAPK10.29926686
84MAP3K40.29808732
85STK38L0.29295973
86AKT20.29118231
87CDK30.28767114
88PRKD20.28391849
89WNK40.27933478
90FES0.26778990
91PRKACG0.26617126
92MAP3K80.25734409
93NLK0.25310287
94PDK20.24717845
95FGFR10.24436777
96PRKCA0.22080567
97TTK0.21837089
98MAPK40.19497717
99ATM0.19147070
100NTRK30.19071864

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.58871176
2Proteasome_Homo sapiens_hsa030503.55230269
3Nitrogen metabolism_Homo sapiens_hsa009102.50130983
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48756858
5Olfactory transduction_Homo sapiens_hsa047402.42046772
6Phototransduction_Homo sapiens_hsa047442.39878078
7Asthma_Homo sapiens_hsa053102.35044592
8Non-homologous end-joining_Homo sapiens_hsa034502.29529679
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15059758
10Type I diabetes mellitus_Homo sapiens_hsa049402.08812671
11Selenocompound metabolism_Homo sapiens_hsa004501.99138525
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.96213374
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94355914
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89482496
15Allograft rejection_Homo sapiens_hsa053301.89171766
16Fanconi anemia pathway_Homo sapiens_hsa034601.85270558
17Autoimmune thyroid disease_Homo sapiens_hsa053201.73462798
18Arginine and proline metabolism_Homo sapiens_hsa003301.73105611
19Base excision repair_Homo sapiens_hsa034101.72900264
20Graft-versus-host disease_Homo sapiens_hsa053321.71395256
21Circadian rhythm_Homo sapiens_hsa047101.59127010
22Basal transcription factors_Homo sapiens_hsa030221.58039250
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56946330
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.54604666
25Vitamin B6 metabolism_Homo sapiens_hsa007501.47960552
26Propanoate metabolism_Homo sapiens_hsa006401.42832404
27RNA degradation_Homo sapiens_hsa030181.42691623
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.38114442
29Linoleic acid metabolism_Homo sapiens_hsa005911.37292012
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34086788
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32081403
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31546662
33One carbon pool by folate_Homo sapiens_hsa006701.31316617
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28629329
35Sphingolipid metabolism_Homo sapiens_hsa006001.22303231
36Homologous recombination_Homo sapiens_hsa034401.22056872
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.14938854
38Chemical carcinogenesis_Homo sapiens_hsa052041.14360951
39Taste transduction_Homo sapiens_hsa047421.13139932
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10033000
41Retinol metabolism_Homo sapiens_hsa008301.09242867
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08608627
43RNA polymerase_Homo sapiens_hsa030201.07453318
44Other glycan degradation_Homo sapiens_hsa005111.06903924
45Protein export_Homo sapiens_hsa030601.02798985
46Tryptophan metabolism_Homo sapiens_hsa003801.02195500
47Purine metabolism_Homo sapiens_hsa002300.99401578
48Antigen processing and presentation_Homo sapiens_hsa046120.95426541
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.92200076
50Caffeine metabolism_Homo sapiens_hsa002320.91869236
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85503031
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83278038
53Primary immunodeficiency_Homo sapiens_hsa053400.80927481
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.79298712
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79053825
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75738164
57Butanoate metabolism_Homo sapiens_hsa006500.74969499
58RNA transport_Homo sapiens_hsa030130.73227591
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72450425
60Folate biosynthesis_Homo sapiens_hsa007900.69319764
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69055005
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68258359
63Dorso-ventral axis formation_Homo sapiens_hsa043200.67082372
64Ovarian steroidogenesis_Homo sapiens_hsa049130.66887565
65Morphine addiction_Homo sapiens_hsa050320.63700893
66Fatty acid elongation_Homo sapiens_hsa000620.60350943
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60128425
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60082628
69Hematopoietic cell lineage_Homo sapiens_hsa046400.59380442
70mRNA surveillance pathway_Homo sapiens_hsa030150.56867314
71T cell receptor signaling pathway_Homo sapiens_hsa046600.55823639
72Parkinsons disease_Homo sapiens_hsa050120.53904808
73Arachidonic acid metabolism_Homo sapiens_hsa005900.53318569
74Oxidative phosphorylation_Homo sapiens_hsa001900.50590587
75Spliceosome_Homo sapiens_hsa030400.49546135
76Regulation of autophagy_Homo sapiens_hsa041400.48564386
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48392950
78Tight junction_Homo sapiens_hsa045300.48013776
79Hepatitis C_Homo sapiens_hsa051600.47326531
80Pyrimidine metabolism_Homo sapiens_hsa002400.47202571
81Measles_Homo sapiens_hsa051620.46641000
82N-Glycan biosynthesis_Homo sapiens_hsa005100.46176702
83Steroid biosynthesis_Homo sapiens_hsa001000.46135422
84Metabolic pathways_Homo sapiens_hsa011000.44212614
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.44164559
86Serotonergic synapse_Homo sapiens_hsa047260.43172688
87Fructose and mannose metabolism_Homo sapiens_hsa000510.41696191
88Viral myocarditis_Homo sapiens_hsa054160.38990183
89Hippo signaling pathway_Homo sapiens_hsa043900.38415837
90Toxoplasmosis_Homo sapiens_hsa051450.34860017
91Ether lipid metabolism_Homo sapiens_hsa005650.34794692
92Pyruvate metabolism_Homo sapiens_hsa006200.34728732
93Sulfur metabolism_Homo sapiens_hsa009200.33555665
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33051671
95Mismatch repair_Homo sapiens_hsa034300.32039042
96beta-Alanine metabolism_Homo sapiens_hsa004100.30441347
97Systemic lupus erythematosus_Homo sapiens_hsa053220.30050498
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28190479
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26883913
100Mineral absorption_Homo sapiens_hsa049780.26635781

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