ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein carboxylation (GO:0018214)	6.93850540
2	peptidyl-glutamic acid carboxylation (GO:0017187)	6.93850540
3	regulation of cholesterol esterification (GO:0010872)	6.90306802
4	negative regulation of fibrinolysis (GO:0051918)	6.62228076
5	high-density lipoprotein particle remodeling (GO:0034375)	6.61745424
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.59578465
7	regulation of fibrinolysis (GO:0051917)	6.49912429
8	regulation of protein activation cascade (GO:2000257)	6.47874547
9	L-phenylalanine catabolic process (GO:0006559)	6.40483946
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.40483946
11	regulation of complement activation (GO:0030449)	6.13924200
12	protein-lipid complex remodeling (GO:0034368)	6.02222974
13	macromolecular complex remodeling (GO:0034367)	6.02222974
14	plasma lipoprotein particle remodeling (GO:0034369)	6.02222974
15	reverse cholesterol transport (GO:0043691)	6.00299433
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.97363502
17	L-phenylalanine metabolic process (GO:0006558)	5.97363502
18	plasma lipoprotein particle assembly (GO:0034377)	5.90343731
19	low-density lipoprotein particle remodeling (GO:0034374)	5.82342115
20	cholesterol efflux (GO:0033344)	5.62954178
21	complement activation, alternative pathway (GO:0006957)	5.62023301
22	blood coagulation, intrinsic pathway (GO:0007597)	5.53678151
23	phospholipid efflux (GO:0033700)	5.52815379
24	negative regulation of sterol transport (GO:0032372)	5.29747048
25	negative regulation of cholesterol transport (GO:0032375)	5.29747048
26	protein-lipid complex assembly (GO:0065005)	5.16438512
27	very-low-density lipoprotein particle assembly (GO:0034379)	5.01812903
28	plasma lipoprotein particle organization (GO:0071827)	4.97749863
29	plasma lipoprotein particle clearance (GO:0034381)	4.89094763
30	glyoxylate metabolic process (GO:0046487)	4.83908325
31	intestinal cholesterol absorption (GO:0030299)	4.75294095
32	aromatic amino acid family catabolic process (GO:0009074)	4.71626322
33	protein-lipid complex subunit organization (GO:0071825)	4.63049675
34	acylglycerol homeostasis (GO:0055090)	4.53352847
35	triglyceride homeostasis (GO:0070328)	4.53352847
36	fibrinolysis (GO:0042730)	4.44964849
37	negative regulation of protein activation cascade (GO:2000258)	4.33722034
38	regulation of plasminogen activation (GO:0010755)	4.33660171
39	drug catabolic process (GO:0042737)	4.29484316
40	exogenous drug catabolic process (GO:0042738)	4.21586033
41	epoxygenase P450 pathway (GO:0019373)	4.11679357
42	negative regulation of blood coagulation (GO:0030195)	4.08446067
43	negative regulation of hemostasis (GO:1900047)	4.08446067
44	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.07875366
45	ethanol oxidation (GO:0006069)	4.02619247
46	negative regulation of lipase activity (GO:0060192)	3.97654452
47	regulation of apoptotic cell clearance (GO:2000425)	3.95042726
48	regulation of humoral immune response (GO:0002920)	3.94653379
49	phospholipid homeostasis (GO:0055091)	3.89176890
50	imidazole-containing compound metabolic process (GO:0052803)	3.86080197
51	protein activation cascade (GO:0072376)	3.79880978
52	regulation of triglyceride catabolic process (GO:0010896)	3.76609443
53	S-adenosylmethionine metabolic process (GO:0046500)	3.76254503
54	negative regulation of coagulation (GO:0050819)	3.75528116
55	cytolysis (GO:0019835)	3.73846655
56	regulation of cytokine secretion involved in immune response (GO:0002739)	3.62990935
57	cholesterol homeostasis (GO:0042632)	3.62702907
58	glutamate metabolic process (GO:0006536)	3.61802309
59	acute-phase response (GO:0006953)	3.61317327
60	bile acid biosynthetic process (GO:0006699)	3.58969730
61	cholesterol transport (GO:0030301)	3.57467119
62	sterol transport (GO:0015918)	3.57467119
63	lipoprotein metabolic process (GO:0042157)	3.56744268
64	sterol homeostasis (GO:0055092)	3.55964480
65	positive regulation of blood coagulation (GO:0030194)	3.52880598
66	positive regulation of hemostasis (GO:1900048)	3.52880598
67	negative regulation of wound healing (GO:0061045)	3.51546615
68	peptidyl-glutamic acid modification (GO:0018200)	3.50177064
69	positive regulation of steroid metabolic process (GO:0045940)	3.49675417
70	negative regulation of complement activation (GO:0045916)	3.44240558
71	tyrosine metabolic process (GO:0006570)	3.44172102
72	bile acid metabolic process (GO:0008206)	3.42398544
73	cellular glucuronidation (GO:0052695)	3.41389057
74	L-ascorbic acid metabolic process (GO:0019852)	3.34482003
75	drug metabolic process (GO:0017144)	3.33579742
76	ethanol metabolic process (GO:0006067)	3.33117733
77	omega-hydroxylase P450 pathway (GO:0097267)	3.30361767
78	heme transport (GO:0015886)	3.24463440
79	positive regulation of coagulation (GO:0050820)	3.24338438
80	glucuronate metabolic process (GO:0019585)	3.22766035
81	uronic acid metabolic process (GO:0006063)	3.22766035
82	indole-containing compound catabolic process (GO:0042436)	3.21530657
83	indolalkylamine catabolic process (GO:0046218)	3.21530657
84	tryptophan catabolic process (GO:0006569)	3.21530657
85	drug transmembrane transport (GO:0006855)	3.19878580
86	positive regulation of triglyceride lipase activity (GO:0061365)	3.18239878
87	positive regulation of lipoprotein lipase activity (GO:0051006)	3.18239878
88	regulation of bile acid biosynthetic process (GO:0070857)	3.18170512
89	intestinal absorption (GO:0050892)	3.17614364
90	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.13992777
91	aromatic amino acid family metabolic process (GO:0009072)	3.13482696
92	complement activation, classical pathway (GO:0006958)	3.13108823
93	cellular anion homeostasis (GO:0030002)	3.10571428
94	bile acid and bile salt transport (GO:0015721)	3.10106116
95	serine family amino acid catabolic process (GO:0009071)	3.06664643
96	C4-dicarboxylate transport (GO:0015740)	3.05809209
97	arginine metabolic process (GO:0006525)	3.04446789
98	negative regulation of sodium ion transport (GO:0010766)	3.02900385
99	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.00855241
100	complement activation (GO:0006956)	2.99102334

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	6.33616000
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.52025041
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.83766409
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.38400847
5	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.27988454
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.27570648
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.25020701
8	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.04733443
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.83825704
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.59783117
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.41281287
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.31166818
13	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.28668923
14	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.17651720
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.16978221
16	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.03990747
17	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.01484807
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.92150385
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.86985902
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.84771996
21	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.79574540
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.75350447
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73854344
24	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.66961532
25	VDR_22108803_ChIP-Seq_LS180_Human	1.64563591
26	NANOG_19829295_ChIP-Seq_ESCs_Human	1.52902087
27	SOX2_19829295_ChIP-Seq_ESCs_Human	1.52902087
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49690313
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.49571848
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.48029892
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.47383194
32	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.40774141
33	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.38768707
34	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.38094274
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.37230623
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.34773248
37	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.34608657
38	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.34342445
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.34110693
40	GATA4_25053715_ChIP-Seq_YYC3_Human	1.34091439
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.31932580
42	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.29831955
43	CDX2_22108803_ChIP-Seq_LS180_Human	1.29519651
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27634666
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.26753453
46	P300_19829295_ChIP-Seq_ESCs_Human	1.25875014
47	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24633276
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.24626402
49	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.23707210
50	AR_20517297_ChIP-Seq_VCAP_Human	1.22367748
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21967733
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21688941
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.19798511
54	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.19518207
55	HTT_18923047_ChIP-ChIP_STHdh_Human	1.19124813
56	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.18233882
57	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.17334699
58	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.16750116
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16687922
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16485917
61	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15072052
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14798758
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.14522065
64	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.13947870
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13909179
66	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12747664
67	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11789016
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.11293837
69	P300_18555785_Chip-Seq_ESCs_Mouse	1.11291432
70	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.10835916
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10757334
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10757334
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09405865
74	FUS_26573619_Chip-Seq_HEK293_Human	1.09223497
75	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.08719730
76	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.07084582
77	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.05911629
78	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.04658974
79	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.03534526
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02478911
81	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.02121586
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01506130
83	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.00927018
84	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.00623466
85	PU1_27457419_Chip-Seq_LIVER_Mouse	1.00501233
86	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.00485920
87	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00014393
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99696212
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98934616
90	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98488033
91	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.98479382
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98357537
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98322501
94	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97888375
95	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.97799429
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96897378
97	GATA3_26560356_Chip-Seq_TH2_Human	0.96286434
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96033283
99	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.94510130
100	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.94377060

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.81635108
2	MP0003195_calcinosis	6.70189640
3	MP0005085_abnormal_gallbladder_physiolo	4.85414552
4	MP0005365_abnormal_bile_salt	4.81727504
5	MP0005360_urolithiasis	4.65757259
6	MP0008875_abnormal_xenobiotic_pharmacok	4.53902478
7	MP0002138_abnormal_hepatobiliary_system	3.77652761
8	MP0010329_abnormal_lipoprotein_level	3.37507455
9	MP0001666_abnormal_nutrient_absorption	3.26549076
10	MP0003252_abnormal_bile_duct	3.00446942
11	MP0003122_maternal_imprinting	2.69484498
12	MP0002876_abnormal_thyroid_physiology	2.40646113
13	MP0005408_hypopigmentation	2.33570005
14	MP0009697_abnormal_copulation	2.22219614
15	MP0003868_abnormal_feces_composition	2.15615169
16	MP0005084_abnormal_gallbladder_morpholo	2.08974358
17	MP0005332_abnormal_amino_acid	1.85299997
18	MP0003806_abnormal_nucleotide_metabolis	1.72374214
19	MP0005646_abnormal_pituitary_gland	1.65411195
20	MP0002132_abnormal_respiratory_system	1.61204421
21	MP0005636_abnormal_mineral_homeostasis	1.55104520
22	MP0001764_abnormal_homeostasis	1.53872426
23	MP0004019_abnormal_vitamin_homeostasis	1.53249877
24	MP0002118_abnormal_lipid_homeostasis	1.52261791
25	MP0009840_abnormal_foam_cell	1.51280015
26	MP0009780_abnormal_chondrocyte_physiolo	1.49124269
27	MP0000609_abnormal_liver_physiology	1.43230803
28	MP0003191_abnormal_cellular_cholesterol	1.39549979
29	MP0005464_abnormal_platelet_physiology	1.39041180
30	MP0004264_abnormal_extraembryonic_tissu	1.38965870
31	MP0003011_delayed_dark_adaptation	1.34365603
32	MP0003567_abnormal_fetal_cardiomyocyte	1.31888684
33	MP0005379_endocrine/exocrine_gland_phen	1.25633086
34	MP0006292_abnormal_olfactory_placode	1.21706443
35	MP0008872_abnormal_physiological_respon	1.18941483
36	MP0006036_abnormal_mitochondrial_physio	1.09298697
37	MP0000639_abnormal_adrenal_gland	1.08689587
38	MP0002102_abnormal_ear_morphology	1.06521425
39	MP0005551_abnormal_eye_electrophysiolog	1.06203633
40	MP0001835_abnormal_antigen_presentation	1.04238171
41	MP0002254_reproductive_system_inflammat	1.03655518
42	MP0005451_abnormal_body_composition	0.99427890
43	MP0001661_extended_life_span	0.98503199
44	MP0003123_paternal_imprinting	0.98170034
45	MP0000604_amyloidosis	0.97073840
46	MP0000598_abnormal_liver_morphology	0.96363915
47	MP0009642_abnormal_blood_homeostasis	0.94952526
48	MP0004782_abnormal_surfactant_physiolog	0.94918240
49	MP0001529_abnormal_vocalization	0.94160478
50	MP0003186_abnormal_redox_activity	0.93871271
51	MP0005319_abnormal_enzyme/_coenzyme	0.93668054
52	MP0003172_abnormal_lysosome_physiology	0.92752876
53	MP0006054_spinal_hemorrhage	0.91071146
54	MP0004147_increased_porphyrin_level	0.90027567
55	MP0009643_abnormal_urine_homeostasis	0.86415265
56	MP0005167_abnormal_blood-brain_barrier	0.85249426
57	MP0001915_intracranial_hemorrhage	0.84474683
58	MP0002909_abnormal_adrenal_gland	0.81385840
59	MP0005584_abnormal_enzyme/coenzyme_acti	0.79610451
60	MP0006035_abnormal_mitochondrial_morpho	0.77168642
61	MP0004142_abnormal_muscle_tone	0.76100208
62	MP0008469_abnormal_protein_level	0.75865036
63	MP0003121_genomic_imprinting	0.75612460
64	MP0003718_maternal_effect	0.75547444
65	MP0003638_abnormal_response/metabolism_	0.70183899
66	MP0002078_abnormal_glucose_homeostasis	0.69658429
67	MP0005220_abnormal_exocrine_pancreas	0.69372060
68	MP0000685_abnormal_immune_system	0.69172632
69	MP0005376_homeostasis/metabolism_phenot	0.68714287
70	MP0009785_altered_susceptibility_to	0.67515357
71	MP0000372_irregular_coat_pigmentation	0.66837238
72	MP0003632_abnormal_nervous_system	0.66100597
73	MP0005395_other_phenotype	0.64948852
74	MP0005670_abnormal_white_adipose	0.64781665
75	MP0002837_dystrophic_cardiac_calcinosis	0.64332592
76	MP0005647_abnormal_sex_gland	0.62421095
77	MP0002166_altered_tumor_susceptibility	0.61275182
78	MP0008004_abnormal_stomach_pH	0.59676534
79	MP0002006_tumorigenesis	0.58787124
80	MP0006072_abnormal_retinal_apoptosis	0.58746101
81	MP0009333_abnormal_splenocyte_physiolog	0.57940572
82	MP0002933_joint_inflammation	0.57821349
83	MP0001756_abnormal_urination	0.56491111
84	MP0001324_abnormal_eye_pigmentation	0.53324834
85	MP0004133_heterotaxia	0.50836063
86	MP0003953_abnormal_hormone_level	0.50650892
87	MP0004883_abnormal_blood_vessel	0.50335959
88	MP0009763_increased_sensitivity_to	0.49696770
89	MP0001986_abnormal_taste_sensitivity	0.49016110
90	MP0008873_increased_physiological_sensi	0.48174440
91	MP0004215_abnormal_myocardial_fiber	0.47623330
92	MP0002089_abnormal_postnatal_growth/wei	0.47111134
93	MP0005253_abnormal_eye_physiology	0.43158657
94	MP0002163_abnormal_gland_morphology	0.42724238
95	MP0003119_abnormal_digestive_system	0.42711535
96	MP0002168_other_aberrant_phenotype	0.40652321
97	MP0002277_abnormal_respiratory_mucosa	0.40292141
98	MP0002090_abnormal_vision	0.38276464
99	MP0005410_abnormal_fertilization	0.38257712
100	MP0002938_white_spotting	0.38041184

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	7.88015737
2	Prolonged partial thromboplastin time (HP:0003645)	7.08287467
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	5.91865072
4	Hypobetalipoproteinemia (HP:0003563)	5.74104258
5	Joint hemorrhage (HP:0005261)	5.70659683
6	Complement deficiency (HP:0004431)	5.20513461
7	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.91588653
8	Abnormality of the common coagulation pathway (HP:0010990)	4.81521304
9	Xanthomatosis (HP:0000991)	4.31341696
10	Spontaneous abortion (HP:0005268)	4.19815354
11	Abnormality of complement system (HP:0005339)	4.02433362
12	Glomerulonephritis (HP:0000099)	3.88022545
13	Hypolipoproteinemia (HP:0010981)	3.86915268
14	Hyperlipoproteinemia (HP:0010980)	3.86228965
15	Intrahepatic cholestasis (HP:0001406)	3.51918203
16	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.50527807
17	Systemic lupus erythematosus (HP:0002725)	3.48765747
18	Menorrhagia (HP:0000132)	3.38895202
19	Conjugated hyperbilirubinemia (HP:0002908)	3.37692982
20	Generalized aminoaciduria (HP:0002909)	3.23327429
21	Broad alveolar ridges (HP:0000187)	3.21341588
22	Hypophosphatemic rickets (HP:0004912)	3.20929326
23	Hypoalphalipoproteinemia (HP:0003233)	3.18801792
24	Gingival bleeding (HP:0000225)	3.10335784
25	Abnormality of urine glucose concentration (HP:0011016)	3.07873812
26	Glycosuria (HP:0003076)	3.07873812
27	Epidermoid cyst (HP:0200040)	2.95540252
28	Vascular calcification (HP:0004934)	2.93825649
29	Pancreatic islet-cell hyperplasia (HP:0004510)	2.81026140
30	Hypoglycemic coma (HP:0001325)	2.77430814
31	Hypercholesterolemia (HP:0003124)	2.74715464
32	Hypothermia (HP:0002045)	2.70971641
33	Abnormality of methionine metabolism (HP:0010901)	2.61661933
34	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.56468888
35	Hepatocellular carcinoma (HP:0001402)	2.55151331
36	Purpura (HP:0000979)	2.54251002
37	Nephritis (HP:0000123)	2.52054880
38	Thrombophlebitis (HP:0004418)	2.51960831
39	Fat malabsorption (HP:0002630)	2.51564769
40	Abnormality of pyrimidine metabolism (HP:0004353)	2.50480047
41	Acanthocytosis (HP:0001927)	2.48066071
42	Hyperglycinemia (HP:0002154)	2.44640445
43	Osteomalacia (HP:0002749)	2.44026126
44	Hyperphosphaturia (HP:0003109)	2.41277803
45	Cardiovascular calcification (HP:0011915)	2.41019620
46	Cerebral palsy (HP:0100021)	2.37858746
47	Proximal tubulopathy (HP:0000114)	2.37317552
48	Intestinal atresia (HP:0011100)	2.35446035
49	Abnormality of transition element cation homeostasis (HP:0011030)	2.32161781
50	Myocardial infarction (HP:0001658)	2.29643568
51	Hepatic necrosis (HP:0002605)	2.23709808
52	Renal cortical cysts (HP:0000803)	2.23525528
53	Rickets (HP:0002748)	2.21435507
54	Abnormality of the intrinsic pathway (HP:0010989)	2.20646663
55	Hemorrhage of the eye (HP:0011885)	2.20271491
56	Enlarged kidneys (HP:0000105)	2.15294734
57	Abnormality of serum amino acid levels (HP:0003112)	2.13880264
58	Abnormality of glycine metabolism (HP:0010895)	2.12567669
59	Abnormality of serine family amino acid metabolism (HP:0010894)	2.12567669
60	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.08107163
61	Acute encephalopathy (HP:0006846)	2.05763978
62	Hepatoblastoma (HP:0002884)	2.03819307
63	Cerebral edema (HP:0002181)	2.02909424
64	Pulmonary embolism (HP:0002204)	2.02842770
65	Gout (HP:0001997)	2.01936019
66	Irregular epiphyses (HP:0010582)	2.00884837
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98419149
68	Abnormality of alanine metabolism (HP:0010916)	1.98419149
69	Hyperalaninemia (HP:0003348)	1.98419149
70	Acute necrotizing encephalopathy (HP:0006965)	1.96602666
71	Joint swelling (HP:0001386)	1.96207280
72	Abnormality of the nasal septum (HP:0000419)	1.94838155
73	Epistaxis (HP:0000421)	1.93167028
74	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.92242733
75	Ketosis (HP:0001946)	1.90558446
76	Abnormality of vitamin metabolism (HP:0100508)	1.90550686
77	Hyperglycinuria (HP:0003108)	1.90426032
78	Reduced antithrombin III activity (HP:0001976)	1.88836146
79	Abnormality of nucleobase metabolism (HP:0010932)	1.84794135
80	Neoplasm of the liver (HP:0002896)	1.83040299
81	Hepatocellular necrosis (HP:0001404)	1.81659542
82	Abnormal urine phosphate concentration (HP:0012599)	1.80223343
83	Abnormality of endocrine pancreas physiology (HP:0012093)	1.78265788
84	Abnormality of the pancreatic islet cells (HP:0006476)	1.78265788
85	Mitochondrial inheritance (HP:0001427)	1.76501328
86	Delayed CNS myelination (HP:0002188)	1.75233357
87	Pigmentary retinal degeneration (HP:0001146)	1.74632703
88	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.73287643
89	Poikilocytosis (HP:0004447)	1.72338250
90	Steatorrhea (HP:0002570)	1.72224939
91	Abnormality of iron homeostasis (HP:0011031)	1.72186325
92	Increased CSF lactate (HP:0002490)	1.70781232
93	Gangrene (HP:0100758)	1.69562079
94	Lethargy (HP:0001254)	1.69266415
95	Recurrent gram-negative bacterial infections (HP:0005420)	1.69068173
96	Vaginal fistula (HP:0004320)	1.67964537
97	Amyloidosis (HP:0011034)	1.66501493
98	Abnormal biliary tract physiology (HP:0012439)	1.66386838
99	Bile duct proliferation (HP:0001408)	1.66386838
100	Hydroxyprolinuria (HP:0003080)	1.65462753

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	4.51287046
2	STK16	3.50433846
3	MAP4K2	3.30100095
4	NEK1	3.07779658
5	WNK3	2.97212829
6	BCKDK	2.39357354
7	GRK1	2.23802787
8	PBK	2.17193502
9	FGFR4	2.15079187
10	NLK	2.09763042
11	TNIK	2.08013449
12	FRK	2.05575929
13	ZAK	1.97486220
14	MST4	1.80310349
15	FGFR3	1.78805006
16	MAP3K12	1.77891714
17	PLK4	1.65258390
18	TAOK3	1.64622494
19	AKT3	1.46875868
20	TRIM28	1.42544902
21	TXK	1.40456138
22	BMPR2	1.33373157
23	WNK4	1.31724950
24	INSRR	1.30298997
25	STK39	1.29189808
26	BCR	1.22329939
27	CSNK1G1	1.20595129
28	EIF2AK1	1.19394981
29	MAPKAPK3	1.14426416
30	CSF1R	1.11970289
31	PLK2	1.08672328
32	PIK3CA	1.07016840
33	KIT	1.06420469
34	ITK	1.05057337
35	NEK2	1.01237258
36	ADRBK2	1.00822576
37	STK38L	0.99815827
38	NTRK3	0.98500454
39	GRK7	0.97622339
40	GRK6	0.94559691
41	BUB1	0.93579877
42	TEC	0.93207005
43	CSNK1A1L	0.92473297
44	TGFBR2	0.92077889
45	MAP3K2	0.91204386
46	ACVR1B	0.90260014
47	ERBB3	0.84227397
48	CSNK1G3	0.83271619
49	ERBB4	0.82441482
50	DAPK1	0.82308173
51	MATK	0.81723109
52	FGR	0.79658482
53	BRSK2	0.79321588
54	OBSCN	0.78457334
55	PLK3	0.77400405
56	EIF2AK3	0.75351924
57	TSSK6	0.72892714
58	SYK	0.72220212
59	VRK2	0.71151840
60	FGFR1	0.70553426
61	NUAK1	0.70098527
62	CSNK2A2	0.69229304
63	MYLK	0.68862881
64	IGF1R	0.68766968
65	TLK1	0.66721274
66	PHKG1	0.66372921
67	PHKG2	0.66372921
68	CSNK1G2	0.65777998
69	FLT3	0.65212605
70	PRKCE	0.63941451
71	FGFR2	0.63388945
72	MINK1	0.63362988
73	PRKACG	0.63034110
74	PDK1	0.62475465
75	PRKCG	0.61552940
76	MAP3K4	0.61497144
77	PIK3CG	0.59796338
78	CSNK2A1	0.59618379
79	MAP2K6	0.59462748
80	BMPR1B	0.59167404
81	RPS6KB1	0.58614712
82	ERBB2	0.58234972
83	MAPK13	0.57239652
84	OXSR1	0.56297144
85	DAPK2	0.54591508
86	PRKAA2	0.52602530
87	JAK3	0.52332688
88	KDR	0.51590871
89	WEE1	0.47577528
90	LCK	0.47564123
91	MAPK11	0.47251097
92	CSNK1E	0.46874697
93	LYN	0.46046042
94	CSNK1A1	0.45609938
95	MKNK2	0.45272367
96	SGK2	0.45252734
97	PRKACA	0.44739219
98	PRKACB	0.42784384
99	PRKCA	0.42629159
100	CSNK1D	0.41339387

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	4.11899921
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.71883641
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.04562291
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.93398541
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.73541180
6	Retinol metabolism_Homo sapiens_hsa00830	2.43346621
7	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.29826179
8	Chemical carcinogenesis_Homo sapiens_hsa05204	2.23666876
9	Arginine biosynthesis_Homo sapiens_hsa00220	2.23069375
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.21372394
11	Caffeine metabolism_Homo sapiens_hsa00232	2.19342898
12	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.19088634
13	Fatty acid degradation_Homo sapiens_hsa00071	2.13325555
14	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.08386813
15	Fat digestion and absorption_Homo sapiens_hsa04975	2.06155118
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04972761
17	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.97076575
18	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.96884184
19	Histidine metabolism_Homo sapiens_hsa00340	1.96363412
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.91643710
21	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.90467060
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.85939739
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.84776331
24	Sulfur metabolism_Homo sapiens_hsa00920	1.79617081
25	Tyrosine metabolism_Homo sapiens_hsa00350	1.68454608
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65555252
27	Butanoate metabolism_Homo sapiens_hsa00650	1.65078237
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64802675
29	Protein export_Homo sapiens_hsa03060	1.62234068
30	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.58381068
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.55611357
32	Peroxisome_Homo sapiens_hsa04146	1.51791904
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.44786077
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38191766
35	Proteasome_Homo sapiens_hsa03050	1.36677144
36	Propanoate metabolism_Homo sapiens_hsa00640	1.32813708
37	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31139746
38	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.29776265
39	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.28270107
40	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.20277993
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.14683651
42	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.12246074
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.09326302
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.08580377
45	Bile secretion_Homo sapiens_hsa04976	1.06754427
46	Nitrogen metabolism_Homo sapiens_hsa00910	1.06476019
47	ABC transporters_Homo sapiens_hsa02010	1.03056656
48	Asthma_Homo sapiens_hsa05310	1.02835877
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.97330179
50	Fatty acid elongation_Homo sapiens_hsa00062	0.96030674
51	Steroid biosynthesis_Homo sapiens_hsa00100	0.93818930
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91289297
53	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88407234
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.86806653
55	Allograft rejection_Homo sapiens_hsa05330	0.86035976
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84698039
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84376536
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82981180
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81143987
60	One carbon pool by folate_Homo sapiens_hsa00670	0.78365475
61	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.77596559
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.76422512
63	Graft-versus-host disease_Homo sapiens_hsa05332	0.72482785
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.72275899
65	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.68330970
66	Metabolic pathways_Homo sapiens_hsa01100	0.64437394
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60598382
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.59644878
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58631416
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.55926217
71	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55588356
72	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.55243719
73	Carbon metabolism_Homo sapiens_hsa01200	0.54432335
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.54388715
75	RNA polymerase_Homo sapiens_hsa03020	0.51560096
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43702369
77	Sulfur relay system_Homo sapiens_hsa04122	0.42949831
78	Glutathione metabolism_Homo sapiens_hsa00480	0.42546060
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41613883
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36461406
81	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36043659
82	Parkinsons disease_Homo sapiens_hsa05012	0.35437354
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33936429
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31327691
85	RNA degradation_Homo sapiens_hsa03018	0.28559078
86	Glucagon signaling pathway_Homo sapiens_hsa04922	0.28207468
87	Regulation of autophagy_Homo sapiens_hsa04140	0.27565338
88	Pertussis_Homo sapiens_hsa05133	0.27224931
89	Folate biosynthesis_Homo sapiens_hsa00790	0.25804952
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.24885910
91	Purine metabolism_Homo sapiens_hsa00230	0.23014720
92	Prion diseases_Homo sapiens_hsa05020	0.21346919
93	Mineral absorption_Homo sapiens_hsa04978	0.20242616
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.17966757
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.17945831
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17549581
97	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.17264952
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.16540711
99	Galactose metabolism_Homo sapiens_hsa00052	0.16176912
100	Huntingtons disease_Homo sapiens_hsa05016	0.16086053

CCT8P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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