CCZ1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.06993166
2regulation of meiosis I (GO:0060631)5.60300289
3DNA methylation involved in gamete generation (GO:0043046)4.81194664
4centriole replication (GO:0007099)4.46972317
5regulation of DNA methylation (GO:0044030)4.40382705
6regulation of female gonad development (GO:2000194)4.32815588
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29418288
8meiotic cell cycle (GO:0051321)4.04729792
9multicellular organism reproduction (GO:0032504)3.95174884
10behavioral response to nicotine (GO:0035095)3.91886888
11positive regulation of histone H3-K4 methylation (GO:0051571)3.89214516
12retinal cone cell development (GO:0046549)3.79483442
13female gamete generation (GO:0007292)3.68422712
14cilium movement (GO:0003341)3.63982790
15DNA deamination (GO:0045006)3.54300354
16epithelial cilium movement (GO:0003351)3.48692251
17CENP-A containing nucleosome assembly (GO:0034080)3.47733256
18regulation of histone H3-K9 methylation (GO:0051570)3.46527235
19cilium or flagellum-dependent cell motility (GO:0001539)3.45904376
20synapsis (GO:0007129)3.43568914
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39457114
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.39457114
23NADH dehydrogenase complex assembly (GO:0010257)3.39457114
24chromatin remodeling at centromere (GO:0031055)3.36389319
25centriole assembly (GO:0098534)3.31608287
26proteasome assembly (GO:0043248)3.29451174
27regulation of acrosome reaction (GO:0060046)3.29324980
28gene silencing by RNA (GO:0031047)3.27300902
29male meiosis I (GO:0007141)3.23790876
30protein complex biogenesis (GO:0070271)3.22956763
31DNA double-strand break processing (GO:0000729)3.20489154
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.20003015
33translesion synthesis (GO:0019985)3.15362615
34axonemal dynein complex assembly (GO:0070286)3.12043261
35replication fork processing (GO:0031297)3.08059522
36DNA replication-dependent nucleosome assembly (GO:0006335)3.07901988
37DNA replication-dependent nucleosome organization (GO:0034723)3.07901988
38pseudouridine synthesis (GO:0001522)3.05505731
39mitochondrial respiratory chain complex assembly (GO:0033108)3.04439192
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02405065
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01273449
42regulation of mitotic spindle checkpoint (GO:1903504)2.98436561
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98436561
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97439546
45postreplication repair (GO:0006301)2.93617505
46reciprocal meiotic recombination (GO:0007131)2.89352247
47reciprocal DNA recombination (GO:0035825)2.89352247
48double-strand break repair via homologous recombination (GO:0000724)2.89244141
49rRNA modification (GO:0000154)2.88469809
50establishment of protein localization to mitochondrial membrane (GO:0090151)2.87789637
51axoneme assembly (GO:0035082)2.87490747
52recombinational repair (GO:0000725)2.86778198
53histone exchange (GO:0043486)2.86106901
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86030974
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80998869
56regulation of double-strand break repair via homologous recombination (GO:0010569)2.80916093
57male meiosis (GO:0007140)2.75682665
58transcription elongation from RNA polymerase I promoter (GO:0006362)2.73514908
59regulation of DNA endoreduplication (GO:0032875)2.69402981
60intraciliary transport (GO:0042073)2.69143623
61response to pheromone (GO:0019236)2.67749586
62respiratory chain complex IV assembly (GO:0008535)2.67454117
63indolalkylamine metabolic process (GO:0006586)2.66868071
64rRNA methylation (GO:0031167)2.66242718
65histone mRNA metabolic process (GO:0008334)2.65201992
66positive regulation of uterine smooth muscle contraction (GO:0070474)2.62954316
67tryptophan catabolic process (GO:0006569)2.61379687
68indole-containing compound catabolic process (GO:0042436)2.61379687
69indolalkylamine catabolic process (GO:0046218)2.61379687
70termination of RNA polymerase III transcription (GO:0006386)2.59809070
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.59809070
72L-fucose catabolic process (GO:0042355)2.59068054
73fucose catabolic process (GO:0019317)2.59068054
74L-fucose metabolic process (GO:0042354)2.59068054
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58488058
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58488058
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.58488058
78base-excision repair, AP site formation (GO:0006285)2.58095680
79oocyte development (GO:0048599)2.56703955
80regulation of cell maturation (GO:1903429)2.56633313
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55793489
82meiotic chromosome segregation (GO:0045132)2.55330258
83tryptophan metabolic process (GO:0006568)2.55294397
84meiosis I (GO:0007127)2.55242662
85chromosome organization involved in meiosis (GO:0070192)2.54251631
86pyrimidine dimer repair (GO:0006290)2.53558729
87ubiquinone biosynthetic process (GO:0006744)2.52159372
88positive regulation of prostaglandin secretion (GO:0032308)2.50974512
89DNA replication-independent nucleosome assembly (GO:0006336)2.50705951
90DNA replication-independent nucleosome organization (GO:0034724)2.50705951
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49541999
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49541999
93positive regulation of meiosis (GO:0045836)2.48929643
94negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48379985
95tachykinin receptor signaling pathway (GO:0007217)2.47580073
96detection of light stimulus involved in sensory perception (GO:0050962)2.47387493
97detection of light stimulus involved in visual perception (GO:0050908)2.47387493
98phosphorelay signal transduction system (GO:0000160)2.46996099
99DNA methylation (GO:0006306)2.46407585
100DNA alkylation (GO:0006305)2.46407585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90641493
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.25019703
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75364460
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94968666
5ZNF274_21170338_ChIP-Seq_K562_Hela2.91680157
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.86276932
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70350295
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67431696
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67135139
10IGF1R_20145208_ChIP-Seq_DFB_Human2.61683403
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52842894
12GBX2_23144817_ChIP-Seq_PC3_Human2.45524378
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.45100517
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38638500
15EWS_26573619_Chip-Seq_HEK293_Human2.28597660
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.26495882
17VDR_22108803_ChIP-Seq_LS180_Human2.25931422
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09536898
19ELK1_19687146_ChIP-ChIP_HELA_Human2.06548815
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04543617
21FUS_26573619_Chip-Seq_HEK293_Human2.03042609
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01530211
23VDR_23849224_ChIP-Seq_CD4+_Human1.98038973
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93483104
25ER_23166858_ChIP-Seq_MCF-7_Human1.92253137
26TAF15_26573619_Chip-Seq_HEK293_Human1.75072270
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72310782
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.71220260
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.65993430
30P300_19829295_ChIP-Seq_ESCs_Human1.65773033
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60830902
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59283254
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.57218442
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55433768
35IRF1_19129219_ChIP-ChIP_H3396_Human1.55407338
36TP53_22573176_ChIP-Seq_HFKS_Human1.54429950
37FOXP3_21729870_ChIP-Seq_TREG_Human1.52819725
38MYC_18940864_ChIP-ChIP_HL60_Human1.51962054
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51502591
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46986778
41CBP_20019798_ChIP-Seq_JUKART_Human1.46986778
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46197368
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45787320
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.44431165
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44085969
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43866553
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40938421
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39360348
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39169438
50BCAT_22108803_ChIP-Seq_LS180_Human1.35424868
51TCF4_23295773_ChIP-Seq_U87_Human1.33623407
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31124684
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30193128
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28268744
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27933938
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24963225
57STAT3_23295773_ChIP-Seq_U87_Human1.23975635
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21721384
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18792536
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15476830
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14308613
62SMAD4_21799915_ChIP-Seq_A2780_Human1.14004359
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13562410
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12922876
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12922876
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10942369
67AR_25329375_ChIP-Seq_VCAP_Human1.10614402
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.07471354
69NANOG_19829295_ChIP-Seq_ESCs_Human1.06927277
70SOX2_19829295_ChIP-Seq_ESCs_Human1.06927277
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.04570671
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.03340070
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02472376
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02356695
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01714901
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.01714901
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01686902
78RUNX2_22187159_ChIP-Seq_PCA_Human1.01347385
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00411217
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00229285
81TAL1_26923725_Chip-Seq_HPCs_Mouse0.99218493
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.99175323
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96517844
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95386138
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94900975
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94566702
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94137087
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92716125
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91787195
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.91085870
91TCF4_22108803_ChIP-Seq_LS180_Human0.91025584
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.90481373
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.90282256
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.89927910
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89299989
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.89269587
97AR_20517297_ChIP-Seq_VCAP_Human0.88577258
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88299121
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87125754
100RNF2_27304074_Chip-Seq_NSC_Mouse0.86873538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.64042423
2MP0006292_abnormal_olfactory_placode3.97521668
3MP0008877_abnormal_DNA_methylation3.51679859
4MP0008058_abnormal_DNA_repair2.76546568
5MP0003890_abnormal_embryonic-extraembry2.68861016
6MP0008057_abnormal_DNA_replication2.61620963
7MP0002160_abnormal_reproductive_system2.59478307
8MP0008789_abnormal_olfactory_epithelium2.47017326
9MP0002653_abnormal_ependyma_morphology2.27027211
10MP0000372_irregular_coat_pigmentation2.25255601
11MP0003693_abnormal_embryo_hatching2.23129576
12MP0005389_reproductive_system_phenotype2.05794552
13MP0010094_abnormal_chromosome_stability2.05462328
14MP0005499_abnormal_olfactory_system2.02677251
15MP0005394_taste/olfaction_phenotype2.02677251
16MP0002837_dystrophic_cardiac_calcinosis2.00758521
17MP0003646_muscle_fatigue2.00744364
18MP0000569_abnormal_digit_pigmentation1.95842551
19MP0008875_abnormal_xenobiotic_pharmacok1.90724429
20MP0002210_abnormal_sex_determination1.85745008
21MP0004142_abnormal_muscle_tone1.83418489
22MP0005075_abnormal_melanosome_morpholog1.80903951
23MP0003136_yellow_coat_color1.76940962
24MP0002138_abnormal_hepatobiliary_system1.74754268
25MP0001929_abnormal_gametogenesis1.73590321
26MP0000427_abnormal_hair_cycle1.72467125
27MP0005646_abnormal_pituitary_gland1.66725927
28MP0005410_abnormal_fertilization1.65416022
29MP0008995_early_reproductive_senescence1.65026818
30MP0003806_abnormal_nucleotide_metabolis1.63260968
31MP0001984_abnormal_olfaction1.61628059
32MP0005395_other_phenotype1.61498619
33MP0005551_abnormal_eye_electrophysiolog1.58377528
34MP0006072_abnormal_retinal_apoptosis1.55732168
35MP0000631_abnormal_neuroendocrine_gland1.53254419
36MP0002638_abnormal_pupillary_reflex1.50625410
37MP0000653_abnormal_sex_gland1.48215011
38MP0001919_abnormal_reproductive_system1.40829285
39MP0001188_hyperpigmentation1.34671609
40MP0003077_abnormal_cell_cycle1.32938289
41MP0001145_abnormal_male_reproductive1.30892935
42MP0006276_abnormal_autonomic_nervous1.30530514
43MP0001293_anophthalmia1.28200071
44MP0003195_calcinosis1.28040899
45MP0003698_abnormal_male_reproductive1.26492762
46MP0002095_abnormal_skin_pigmentation1.25323498
47MP0003699_abnormal_female_reproductive1.24662625
48MP0005645_abnormal_hypothalamus_physiol1.23723959
49MP0002735_abnormal_chemical_nociception1.23407649
50MP0003252_abnormal_bile_duct1.21390984
51MP0004043_abnormal_pH_regulation1.20369151
52MP0002272_abnormal_nervous_system1.16398674
53MP0001324_abnormal_eye_pigmentation1.15486756
54MP0001119_abnormal_female_reproductive1.13342793
55MP0001968_abnormal_touch/_nociception1.12889196
56MP0003186_abnormal_redox_activity1.11911342
57MP0002751_abnormal_autonomic_nervous1.08837850
58MP0002161_abnormal_fertility/fecundity1.06135307
59MP0002234_abnormal_pharynx_morphology1.03717009
60MP0003111_abnormal_nucleus_morphology1.02447390
61MP0006035_abnormal_mitochondrial_morpho1.01778393
62MP0008872_abnormal_physiological_respon1.00979010
63MP0001529_abnormal_vocalization1.00594041
64MP0009745_abnormal_behavioral_response0.97699692
65MP0002736_abnormal_nociception_after0.97389313
66MP0002102_abnormal_ear_morphology0.96590149
67MP0005253_abnormal_eye_physiology0.95118341
68MP0000383_abnormal_hair_follicle0.93849563
69MP0009046_muscle_twitch0.93621190
70MP0003121_genomic_imprinting0.92226707
71MP0002277_abnormal_respiratory_mucosa0.91854689
72MP0001986_abnormal_taste_sensitivity0.90912036
73MP0005266_abnormal_metabolism0.90595577
74MP0005085_abnormal_gallbladder_physiolo0.88818174
75MP0005174_abnormal_tail_pigmentation0.88334700
76MP0009697_abnormal_copulation0.87542442
77MP0004957_abnormal_blastocyst_morpholog0.87354345
78MP0002163_abnormal_gland_morphology0.83733187
79MP0000015_abnormal_ear_pigmentation0.80248948
80MP0001485_abnormal_pinna_reflex0.80183571
81MP0006036_abnormal_mitochondrial_physio0.77922392
82MP0003937_abnormal_limbs/digits/tail_de0.73689852
83MP0005195_abnormal_posterior_eye0.73520304
84MP0002876_abnormal_thyroid_physiology0.73258704
85MP0003786_premature_aging0.73241323
86MP0001905_abnormal_dopamine_level0.72581529
87MP0010678_abnormal_skin_adnexa0.71557465
88MP0000358_abnormal_cell_content/0.70792420
89MP0002928_abnormal_bile_duct0.70620624
90MP0002822_catalepsy0.69994533
91MP0001486_abnormal_startle_reflex0.69919626
92MP0001501_abnormal_sleep_pattern0.69540404
93MP0005386_behavior/neurological_phenoty0.67820321
94MP0004924_abnormal_behavior0.67820321
95MP0002938_white_spotting0.67629350
96MP0010307_abnormal_tumor_latency0.67264024
97MP0002233_abnormal_nose_morphology0.66567464
98MP0005647_abnormal_sex_gland0.65735172
99MP0008932_abnormal_embryonic_tissue0.65455806
100MP0002229_neurodegeneration0.65053385

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.40972863
2Abnormality of midbrain morphology (HP:0002418)4.20485730
3Molar tooth sign on MRI (HP:0002419)4.20485730
4Pancreatic fibrosis (HP:0100732)4.10404911
5Pancreatic cysts (HP:0001737)4.02059224
6Abnormal ciliary motility (HP:0012262)3.69919401
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.69629635
8Absent/shortened dynein arms (HP:0200106)3.69629635
9Abnormal respiratory motile cilium physiology (HP:0012261)3.55472904
10Chronic hepatic failure (HP:0100626)3.50680005
11True hermaphroditism (HP:0010459)3.31168670
12Supernumerary spleens (HP:0009799)3.28721449
13Nephronophthisis (HP:0000090)3.27947887
14Lipid accumulation in hepatocytes (HP:0006561)3.21888292
15Increased hepatocellular lipid droplets (HP:0006565)3.12161776
16Rhinitis (HP:0012384)3.07194473
17Abnormal biliary tract physiology (HP:0012439)2.99455245
18Bile duct proliferation (HP:0001408)2.99455245
193-Methylglutaconic aciduria (HP:0003535)2.83966896
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.82836398
21Mitochondrial inheritance (HP:0001427)2.79262441
22Abnormality of the renal medulla (HP:0100957)2.76150705
23Aplasia/Hypoplasia of the tongue (HP:0010295)2.75617443
24Chromsome breakage (HP:0040012)2.73689746
25Abnormality of the renal cortex (HP:0011035)2.73479556
26Hypoplasia of the pons (HP:0012110)2.73367742
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72370193
28Abnormal respiratory epithelium morphology (HP:0012253)2.71983293
29Abnormal respiratory motile cilium morphology (HP:0005938)2.71983293
30Abnormality of the pons (HP:0007361)2.69010439
31Medial flaring of the eyebrow (HP:0010747)2.60818622
32Increased CSF lactate (HP:0002490)2.55368192
33Abnormality of chromosome stability (HP:0003220)2.54983130
34Renal Fanconi syndrome (HP:0001994)2.54649010
35Abnormal number of erythroid precursors (HP:0012131)2.48574022
36Anencephaly (HP:0002323)2.47127101
37Acute necrotizing encephalopathy (HP:0006965)2.41577194
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.39210275
39Median cleft lip (HP:0000161)2.38744054
40Acute encephalopathy (HP:0006846)2.36811150
41Congenital stationary night blindness (HP:0007642)2.36563955
42Hepatocellular necrosis (HP:0001404)2.32274505
43Abnormality of the ileum (HP:0001549)2.31700723
44Cystic liver disease (HP:0006706)2.31541200
45Meckel diverticulum (HP:0002245)2.29735260
46Chronic bronchitis (HP:0004469)2.27975375
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.27698423
48Hypoplasia of the fovea (HP:0007750)2.27698423
49Colon cancer (HP:0003003)2.24482628
50Septo-optic dysplasia (HP:0100842)2.21353478
51Short tibia (HP:0005736)2.19915031
52Progressive macrocephaly (HP:0004481)2.19000636
53Hepatic necrosis (HP:0002605)2.18864952
54Abnormality of cells of the erythroid lineage (HP:0012130)2.18740412
55Increased intramyocellular lipid droplets (HP:0012240)2.17919991
56Congenital hepatic fibrosis (HP:0002612)2.17523611
57Abnormality of renal resorption (HP:0011038)2.14263758
58Occipital encephalocele (HP:0002085)2.11803773
59Tubular atrophy (HP:0000092)2.11651030
60Gaze-evoked nystagmus (HP:0000640)2.11201157
61Abnormal mitochondria in muscle tissue (HP:0008316)2.08748506
62Metaphyseal dysplasia (HP:0100255)2.06437244
63Abnormality of the preputium (HP:0100587)2.05554699
64Abnormal rod and cone electroretinograms (HP:0008323)2.05030508
65Postaxial foot polydactyly (HP:0001830)2.04690541
66Abnormality of the fovea (HP:0000493)2.02992611
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02247175
68Sloping forehead (HP:0000340)2.01481302
69Oligodactyly (hands) (HP:0001180)2.01409542
70Attenuation of retinal blood vessels (HP:0007843)2.01243954
71Type II lissencephaly (HP:0007260)1.99659149
72Exertional dyspnea (HP:0002875)1.98276896
73Clubbing of toes (HP:0100760)1.97048048
74Aplastic anemia (HP:0001915)1.94454077
75Fair hair (HP:0002286)1.92994698
76Sclerocornea (HP:0000647)1.92491785
77Pendular nystagmus (HP:0012043)1.91845148
78Abnormality of the labia minora (HP:0012880)1.91723351
79Increased muscle lipid content (HP:0009058)1.89245559
80Bronchiectasis (HP:0002110)1.87019539
81Osteomalacia (HP:0002749)1.86405115
82Genital tract atresia (HP:0001827)1.84728126
83Oculomotor apraxia (HP:0000657)1.83314003
84Congenital primary aphakia (HP:0007707)1.83066186
85Gait imbalance (HP:0002141)1.82806575
86Absent septum pellucidum (HP:0001331)1.82210909
87Increased serum lactate (HP:0002151)1.79800614
88Protruding tongue (HP:0010808)1.79345142
89Cleft eyelid (HP:0000625)1.79220841
90Nephrogenic diabetes insipidus (HP:0009806)1.77203149
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74889457
92Male pseudohermaphroditism (HP:0000037)1.74805890
93Absent thumb (HP:0009777)1.74727749
94Preaxial hand polydactyly (HP:0001177)1.73174134
95Postaxial hand polydactyly (HP:0001162)1.72187756
96Triphalangeal thumb (HP:0001199)1.70931211
97Polydipsia (HP:0001959)1.68797475
98Abnormal drinking behavior (HP:0030082)1.68797475
99Abnormality of the septum pellucidum (HP:0007375)1.67624788
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67056903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.06463787
2ZAK3.62917407
3FRK3.48629029
4NUAK12.66286424
5EIF2AK32.61774338
6TLK12.48221168
7ACVR1B2.32551951
8VRK12.07897605
9CDC71.92246292
10VRK21.89136610
11TAOK31.88726019
12MAP3K91.84228319
13NEK21.82617378
14MAP3K41.80178267
15MAP4K21.65371644
16ARAF1.64680974
17STK38L1.63007174
18STK391.58818737
19ADRBK21.58242485
20PINK11.53997805
21MAPK131.48858808
22EIF2AK11.47755725
23STK161.44193929
24WNK41.33358142
25TGFBR11.33127767
26GRK11.28982736
27MST41.20245339
28MAPKAPK31.18358974
29TTK1.16640229
30PBK1.15271994
31PLK11.12711974
32MUSK1.08397582
33CDK81.08081890
34CDK91.07720958
35MAP3K131.06867742
36MKNK21.05817845
37TNIK1.05385135
38BRAF1.02281043
39PLK31.00685518
40BRSK21.00249611
41MAP3K120.99144766
42NEK60.99090588
43STK240.98686830
44PRKCI0.98448399
45STK30.98151956
46MAP2K70.97250394
47MAPKAPK50.93313265
48TXK0.92538608
49AURKA0.91979081
50MAPK150.91876036
51MARK30.91683903
52TAF10.89812912
53RPS6KB20.88505172
54DYRK20.87926564
55PIM10.83236987
56PLK20.82642919
57TEC0.80754780
58CSNK1G20.80689480
59RPS6KA50.79958189
60ATR0.79554185
61CDK70.77720812
62WNK30.76831068
63CCNB10.76485616
64MELK0.75666839
65CHEK20.74533299
66CSNK1G10.73492169
67CASK0.72653938
68SRPK10.72299771
69PLK40.71508331
70CSNK1G30.71399399
71OXSR10.70741859
72NME10.70171220
73MKNK10.66574633
74MET0.65931702
75PNCK0.64277660
76BUB10.63093970
77ATM0.61347235
78CHUK0.60355482
79PKN10.55462751
80ADRBK10.51101916
81IKBKB0.48949519
82AKT30.48663724
83AURKB0.47925178
84PRKD30.47891801
85EIF2AK20.47088194
86CSNK1E0.46720521
87CAMKK20.46552628
88CSNK1A1L0.45698960
89DYRK30.45062622
90PRKCE0.43150505
91CHEK10.42841916
92RPS6KA40.42267148
93CSNK1D0.41851830
94CAMK2A0.41539836
95INSRR0.40972754
96LATS10.38956014
97NTRK20.38142893
98RAF10.37342294
99NEK10.36840141
100PRKACB0.36801976

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.74681544
2Oxidative phosphorylation_Homo sapiens_hsa001903.22786041
3Homologous recombination_Homo sapiens_hsa034402.82417895
4Parkinsons disease_Homo sapiens_hsa050122.76901506
5RNA polymerase_Homo sapiens_hsa030202.73107811
6Fanconi anemia pathway_Homo sapiens_hsa034602.60703760
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43175971
8Ribosome_Homo sapiens_hsa030102.42986093
9Huntingtons disease_Homo sapiens_hsa050162.31004488
10Mismatch repair_Homo sapiens_hsa034302.30295452
11RNA degradation_Homo sapiens_hsa030182.25321703
12Nucleotide excision repair_Homo sapiens_hsa034202.03960994
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03469443
14Phototransduction_Homo sapiens_hsa047442.00539386
15Proteasome_Homo sapiens_hsa030501.96353742
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93650824
17Protein export_Homo sapiens_hsa030601.82965898
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74611477
19Base excision repair_Homo sapiens_hsa034101.72615213
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69261449
21Alzheimers disease_Homo sapiens_hsa050101.68968133
22Caffeine metabolism_Homo sapiens_hsa002321.65626153
23Systemic lupus erythematosus_Homo sapiens_hsa053221.57629500
24DNA replication_Homo sapiens_hsa030301.54579990
25Cell cycle_Homo sapiens_hsa041101.54264996
26RNA transport_Homo sapiens_hsa030131.46128516
27Non-homologous end-joining_Homo sapiens_hsa034501.43118426
28Nicotine addiction_Homo sapiens_hsa050331.43037020
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40015160
30Spliceosome_Homo sapiens_hsa030401.37091623
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33043922
32Olfactory transduction_Homo sapiens_hsa047401.29494898
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28658029
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28339658
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28288191
36Selenocompound metabolism_Homo sapiens_hsa004501.27818052
37Pyrimidine metabolism_Homo sapiens_hsa002401.23921864
38Cardiac muscle contraction_Homo sapiens_hsa042601.23662267
39Regulation of autophagy_Homo sapiens_hsa041401.21841345
40One carbon pool by folate_Homo sapiens_hsa006701.21604709
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19854970
42Propanoate metabolism_Homo sapiens_hsa006401.12274601
43Purine metabolism_Homo sapiens_hsa002301.11329045
44Asthma_Homo sapiens_hsa053101.10759822
45Oocyte meiosis_Homo sapiens_hsa041141.10142509
46Tryptophan metabolism_Homo sapiens_hsa003801.07399796
47Taste transduction_Homo sapiens_hsa047421.06571663
48Butanoate metabolism_Homo sapiens_hsa006501.00658563
49p53 signaling pathway_Homo sapiens_hsa041151.00151720
50Circadian rhythm_Homo sapiens_hsa047100.94364916
51Alcoholism_Homo sapiens_hsa050340.91763251
52Dorso-ventral axis formation_Homo sapiens_hsa043200.82996479
53Linoleic acid metabolism_Homo sapiens_hsa005910.82462574
54ABC transporters_Homo sapiens_hsa020100.82410682
55Ovarian steroidogenesis_Homo sapiens_hsa049130.81335105
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.80667224
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79529461
58Nitrogen metabolism_Homo sapiens_hsa009100.73912514
59Chemical carcinogenesis_Homo sapiens_hsa052040.72610090
60Peroxisome_Homo sapiens_hsa041460.72468692
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.70106527
62Morphine addiction_Homo sapiens_hsa050320.69515309
63mRNA surveillance pathway_Homo sapiens_hsa030150.63216431
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62754979
65Primary immunodeficiency_Homo sapiens_hsa053400.60986664
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.60949878
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60691399
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60600140
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57907640
70Metabolic pathways_Homo sapiens_hsa011000.54901002
71Folate biosynthesis_Homo sapiens_hsa007900.53212112
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50568408
73Serotonergic synapse_Homo sapiens_hsa047260.50544351
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.48305575
75Collecting duct acid secretion_Homo sapiens_hsa049660.47268028
76Rheumatoid arthritis_Homo sapiens_hsa053230.45785648
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45642556
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45447582
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44740380
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42556738
81Ether lipid metabolism_Homo sapiens_hsa005650.41228079
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39867953
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38854356
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37216332
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36970210
86GABAergic synapse_Homo sapiens_hsa047270.34926808
87Sulfur metabolism_Homo sapiens_hsa009200.33341658
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32776088
89Glutamatergic synapse_Homo sapiens_hsa047240.32773566
90Viral carcinogenesis_Homo sapiens_hsa052030.32613528
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31923976
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31548072
93TGF-beta signaling pathway_Homo sapiens_hsa043500.30839987
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.30370495
95Retinol metabolism_Homo sapiens_hsa008300.30082922
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29307105
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25272243
98Allograft rejection_Homo sapiens_hsa053300.24570876
99Autoimmune thyroid disease_Homo sapiens_hsa053200.24105702
100Pyruvate metabolism_Homo sapiens_hsa006200.19639970

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