CD101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)7.58140689
2regulation of B cell receptor signaling pathway (GO:0050855)6.81252066
3cellular extravasation (GO:0045123)6.22297366
4negative regulation of cell killing (GO:0031342)5.95204812
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.95204812
6positive regulation of gamma-delta T cell activation (GO:0046645)5.59799327
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.28174912
8neutrophil activation involved in immune response (GO:0002283)4.97025192
9negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.82916266
10tolerance induction (GO:0002507)4.73692103
11positive regulation of mast cell activation (GO:0033005)4.63164640
12cellular response to interleukin-15 (GO:0071350)4.57996166
13macrophage differentiation (GO:0030225)4.56362434
14response to interleukin-15 (GO:0070672)4.50198336
15negative T cell selection (GO:0043383)4.49267036
16neutrophil activation (GO:0042119)4.47815033
17response to peptidoglycan (GO:0032494)4.47645527
18negative thymic T cell selection (GO:0045060)4.47424718
19neutrophil mediated immunity (GO:0002446)4.40366017
20respiratory burst (GO:0045730)4.37513488
21positive thymic T cell selection (GO:0045059)4.28372377
22detection of molecule of bacterial origin (GO:0032490)4.22607429
23positive regulation by symbiont of host defense response (GO:0052509)4.21082590
24modulation by symbiont of host defense response (GO:0052031)4.21082590
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21082590
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21082590
27positive regulation by organism of defense response of other organism involved in symbiotic interact4.21082590
28modulation by symbiont of host immune response (GO:0052553)4.21082590
29regulation of gamma-delta T cell differentiation (GO:0045586)4.20667838
30detection of external biotic stimulus (GO:0098581)4.18762916
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17092695
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17092695
33regulation of interleukin-12 biosynthetic process (GO:0045075)4.15396492
34response to host immune response (GO:0052572)4.12585865
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.12585865
36regulation of gamma-delta T cell activation (GO:0046643)4.11080005
37granulocyte activation (GO:0036230)4.10950635
38neutrophil chemotaxis (GO:0030593)4.04891081
39antigen processing and presentation of endogenous antigen (GO:0019883)3.94960174
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.94873466
41microglial cell activation (GO:0001774)3.94174409
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.94110288
43neutrophil migration (GO:1990266)3.93436809
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91071934
45response to host (GO:0075136)3.91071934
46response to host defenses (GO:0052200)3.91071934
47leukocyte cell-cell adhesion (GO:0007159)3.88325027
48regulation of interferon-beta biosynthetic process (GO:0045357)3.88116505
49activated T cell proliferation (GO:0050798)3.78274131
50thymic T cell selection (GO:0045061)3.78167922
51detection of biotic stimulus (GO:0009595)3.77305080
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.75499363
53defense response to fungus (GO:0050832)3.75327258
54regulation of B cell differentiation (GO:0045577)3.73569499
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.72877871
56macrophage activation (GO:0042116)3.71224175
57granulocyte chemotaxis (GO:0071621)3.68811755
58negative regulation of T cell mediated immunity (GO:0002710)3.67238360
59positive T cell selection (GO:0043368)3.67088737
60negative regulation of phagocytosis (GO:0050765)3.66064706
61regulation of T cell tolerance induction (GO:0002664)3.62821048
62interferon-gamma production (GO:0032609)3.58333111
63negative regulation of interleukin-12 production (GO:0032695)3.56917990
64granulocyte migration (GO:0097530)3.56404626
65immunoglobulin mediated immune response (GO:0016064)3.56065632
66T cell migration (GO:0072678)3.54069772
67regulation of mast cell activation (GO:0033003)3.53495614
68T cell selection (GO:0045058)3.53272602
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49777064
70regulation of mast cell activation involved in immune response (GO:0033006)3.47109144
71negative regulation of leukocyte mediated immunity (GO:0002704)3.45081859
72response to muramyl dipeptide (GO:0032495)3.41469536
73myeloid leukocyte mediated immunity (GO:0002444)3.41258930
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40162897
75positive regulation of tolerance induction (GO:0002645)3.37953096
76positive regulation of B cell differentiation (GO:0045579)3.37535004
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36700260
78response to fungus (GO:0009620)3.35398580
79positive regulation of mast cell activation involved in immune response (GO:0033008)3.31224563
80positive regulation of mast cell degranulation (GO:0043306)3.31224563
81T cell costimulation (GO:0031295)3.29506233
82production of molecular mediator involved in inflammatory response (GO:0002532)3.28222701
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26241969
84regulation of interleukin-2 biosynthetic process (GO:0045076)3.25784613
85regulation of alpha-beta T cell proliferation (GO:0046640)3.25738332
86detection of other organism (GO:0098543)3.25352231
87lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24849453
88B cell receptor signaling pathway (GO:0050853)3.24065472
89lymphocyte costimulation (GO:0031294)3.23008709
90leukocyte degranulation (GO:0043299)3.22890104
91dendritic cell migration (GO:0036336)3.21879027
92negative regulation of erythrocyte differentiation (GO:0045647)3.17671198
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.17046235
94regulation of receptor binding (GO:1900120)3.16739265
95cellular defense response (GO:0006968)3.16687150
96dendritic cell chemotaxis (GO:0002407)3.16589271
97regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16582240
98T cell receptor signaling pathway (GO:0050852)3.16500416
99antigen processing and presentation via MHC class Ib (GO:0002475)3.15677379
100negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13853141
101interferon-gamma-mediated signaling pathway (GO:0060333)3.13721379
102regulation of tolerance induction (GO:0002643)3.11831913
103positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11760471
104leukocyte migration involved in inflammatory response (GO:0002523)3.11528902
105antigen receptor-mediated signaling pathway (GO:0050851)3.10981577
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.09041752
107detection of bacterium (GO:0016045)3.08420985
108B cell mediated immunity (GO:0019724)3.08276509
109positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05680669
110regulation of isotype switching to IgG isotypes (GO:0048302)3.05043721
111endodermal cell differentiation (GO:0035987)3.00917124
112oxygen transport (GO:0015671)3.00179562
113positive regulation of cellular amide metabolic process (GO:0034250)3.00073297
114defense response to protozoan (GO:0042832)2.99692597
115myeloid cell activation involved in immune response (GO:0002275)2.98885088
116regulation of regulatory T cell differentiation (GO:0045589)2.98706219
117regulation of leukocyte degranulation (GO:0043300)2.98557305
118myeloid leukocyte activation (GO:0002274)2.97164581
119negative regulation of type 2 immune response (GO:0002829)2.93292272
120macrophage activation involved in immune response (GO:0002281)2.92453550
121JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90774152
122positive regulation of interferon-alpha production (GO:0032727)2.89219812
123negative regulation of interleukin-6 production (GO:0032715)2.86383862
124regulation of mast cell degranulation (GO:0043304)2.86316845
125negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85912925
126type I interferon signaling pathway (GO:0060337)2.85867566
127cellular response to type I interferon (GO:0071357)2.85867566
128negative regulation of cytokine production involved in immune response (GO:0002719)2.85642936
129response to type I interferon (GO:0034340)2.85432025
130regulation of regulated secretory pathway (GO:1903305)2.84958960
131regulation of interferon-alpha production (GO:0032647)2.84747070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.53137457
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.37348863
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.82768728
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.10019081
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.06099358
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.62122237
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.59529136
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45125406
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.44569581
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14763401
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09581497
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.02635108
13STAT4_19710469_ChIP-ChIP_TH1__Mouse3.00346801
14RUNX_20019798_ChIP-Seq_JUKART_Human3.00096025
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.88886929
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.86389927
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.83092559
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79790029
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72897669
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.65609692
21* MYB_26560356_Chip-Seq_TH2_Human2.65535110
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.64002550
23MAF_26560356_Chip-Seq_TH1_Human2.57795233
24* SPI1_23547873_ChIP-Seq_NB4_Human2.50714036
25VDR_21846776_ChIP-Seq_THP-1_Human2.40016852
26UTX_26944678_Chip-Seq_JUKART_Human2.38841977
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.29717558
28MYB_26560356_Chip-Seq_TH1_Human2.21904466
29STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20196445
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16075130
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14939287
32VDR_24763502_ChIP-Seq_THP-1_Human2.14444903
33SPI1_23127762_ChIP-Seq_K562_Human2.10492915
34MYC_22102868_ChIP-Seq_BL_Human2.05607626
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04846996
36SCL_19346495_ChIP-Seq_HPC-7_Human1.98593097
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94016406
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93882579
39GATA3_27048872_Chip-Seq_THYMUS_Human1.91610400
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88190385
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86508348
42TCF7_22412390_ChIP-Seq_EML_Mouse1.80585751
43MAF_26560356_Chip-Seq_TH2_Human1.76193928
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74708302
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74155720
46PU_27001747_Chip-Seq_BMDM_Mouse1.71903898
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69051723
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64651176
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61048250
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60975134
51GATA1_22025678_ChIP-Seq_K562_Human1.60825673
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59983011
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.52858043
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52544418
55KDM2B_26808549_Chip-Seq_DND41_Human1.50774234
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49572317
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48280546
58* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44483508
59GATA3_26560356_Chip-Seq_TH2_Human1.44195576
60VDR_24787735_ChIP-Seq_THP-1_Human1.43540284
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.37351185
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36260246
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33492238
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31863359
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27675614
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26175195
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.22653077
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22440164
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21627168
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21111624
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18084168
72* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16592787
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14137039
74EGR1_19032775_ChIP-ChIP_M12_Human1.13646821
75E2F7_22180533_ChIP-Seq_HELA_Human1.12956408
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09193235
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08248821
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.08033683
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07734596
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07039336
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.05749324
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04932728
83LXR_22292898_ChIP-Seq_THP-1_Human1.04432217
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04362672
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03538984
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03220891
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02157138
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01679251
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92667430
90GATA2_19941826_ChIP-Seq_K562_Human0.92195835
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.91440971
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87202095
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86192736
94BCOR_27268052_Chip-Seq_Bcells_Human0.85660616
95SPI1_20517297_ChIP-Seq_HL60_Human0.84646090
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82546163
97TFEB_21752829_ChIP-Seq_HELA_Human0.80695954
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79320101
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79050804
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78065292
101SMRT_27268052_Chip-Seq_Bcells_Human0.75933316
102CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75016759
103BCL6_27268052_Chip-Seq_Bcells_Human0.74738695
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74073751
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74052203
106NCOR1_26117541_ChIP-Seq_K562_Human0.71668440
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68801419
108P300_27268052_Chip-Seq_Bcells_Human0.68691661
109SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.65371776
110ETS1_22383799_ChIP-Seq_G1ME_Mouse0.65310399
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64388346
112GATA1_19941826_ChIP-Seq_K562_Human0.64264229
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.64103893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.55877823
2MP0009278_abnormal_bone_marrow3.40892597
3MP0005671_abnormal_response_to3.40719007
4MP0003303_peritoneal_inflammation3.40258179
5MP0009785_altered_susceptibility_to3.30220795
6MP0001835_abnormal_antigen_presentation3.16110160
7MP0002837_dystrophic_cardiac_calcinosis2.92967548
8MP0002419_abnormal_innate_immunity2.91165514
9MP0001853_heart_inflammation2.86939664
10MP0005000_abnormal_immune_tolerance2.79222894
11MP0001800_abnormal_humoral_immune2.70957709
12MP0000685_abnormal_immune_system2.70532443
13MP0005025_abnormal_response_to2.62829689
14MP0003724_increased_susceptibility_to2.60675738
15MP0002933_joint_inflammation2.56239027
16MP0004510_myositis2.51889958
17MP0001790_abnormal_immune_system2.51539130
18MP0005387_immune_system_phenotype2.51539130
19MP0005167_abnormal_blood-brain_barrier2.48148647
20MP0002452_abnormal_antigen_presenting2.48126317
21MP0002148_abnormal_hypersensitivity_rea2.48049781
22MP0002420_abnormal_adaptive_immunity2.47631724
23MP0001819_abnormal_immune_cell2.46313334
24MP0003763_abnormal_thymus_physiology2.44115110
25MP0002723_abnormal_immune_serum2.41018274
26MP0002405_respiratory_system_inflammati2.39391225
27MP0001533_abnormal_skeleton_physiology2.24803605
28MP0000858_altered_metastatic_potential2.09342841
29MP0008260_abnormal_autophagy2.07997589
30MP0006082_CNS_inflammation2.06279950
31MP0002396_abnormal_hematopoietic_system2.03067816
32MP0003300_gastrointestinal_ulcer2.01072223
33MP0002398_abnormal_bone_marrow1.96618577
34MP0000343_altered_response_to1.94506266
35MP0005397_hematopoietic_system_phenotyp1.93005237
36MP0001545_abnormal_hematopoietic_system1.93005237
37MP0000716_abnormal_immune_system1.90822705
38MP0002166_altered_tumor_susceptibility1.89387542
39MP0001845_abnormal_inflammatory_respons1.85414319
40MP0010155_abnormal_intestine_physiology1.85031517
41MP0005464_abnormal_platelet_physiology1.72202796
42MP0009764_decreased_sensitivity_to1.70114738
43MP0003448_altered_tumor_morphology1.68856198
44MP0009333_abnormal_splenocyte_physiolog1.68492410
45MP0000689_abnormal_spleen_morphology1.67629047
46MP0003279_aneurysm1.66031609
47MP0004947_skin_inflammation1.61924439
48MP0004808_abnormal_hematopoietic_stem1.60904259
49MP0001873_stomach_inflammation1.57642844
50MP0002722_abnormal_immune_system1.57532148
51MP0003075_altered_response_to1.57320850
52MP0003828_pulmonary_edema1.52362689
53MP0002429_abnormal_blood_cell1.51863712
54MP0000569_abnormal_digit_pigmentation1.51804099
55MP0002006_tumorigenesis1.50496643
56MP0003866_abnormal_defecation1.44825258
57MP0003191_abnormal_cellular_cholesterol1.44760138
58MP0004883_abnormal_blood_vessel1.43851992
59MP0003690_abnormal_glial_cell1.39343700
60MP0000703_abnormal_thymus_morphology1.36298621
61MP0001851_eye_inflammation1.35575259
62MP0008469_abnormal_protein_level1.34329715
63MP0005023_abnormal_wound_healing1.31710735
64MP0002277_abnormal_respiratory_mucosa1.30131329
65MP0005166_decreased_susceptibility_to1.28262822
66MP0003183_abnormal_peptide_metabolism1.24133232
67MP0005058_abnormal_lysosome_morphology1.23575200
68MP0003453_abnormal_keratinocyte_physiol1.23453012
69MP0003806_abnormal_nucleotide_metabolis1.19948585
70MP0000465_gastrointestinal_hemorrhage1.17873228
71MP0005310_abnormal_salivary_gland1.14700389
72MP0000015_abnormal_ear_pigmentation1.11632865
73MP0005390_skeleton_phenotype1.05868680
74MP0008004_abnormal_stomach_pH1.04391451
75MP0003656_abnormal_erythrocyte_physiolo1.00524631
76MP0004381_abnormal_hair_follicle0.97184879
77MP0003172_abnormal_lysosome_physiology0.96109251
78MP0009840_abnormal_foam_cell0.95897402
79MP0002998_abnormal_bone_remodeling0.95713529
80MP0005076_abnormal_cell_differentiation0.92756808
81MP0005164_abnormal_response_to0.89522468
82MP0009763_increased_sensitivity_to0.84743546
83MP0008961_abnormal_basal_metabolism0.80608509
84MP0003638_abnormal_response/metabolism_0.78872395
85MP0005075_abnormal_melanosome_morpholog0.78089156
86MP0006054_spinal_hemorrhage0.78026530
87MP0003795_abnormal_bone_structure0.75345597
88MP0009765_abnormal_xenobiotic_induced0.74558822
89MP0005451_abnormal_body_composition0.73977757
90MP0000920_abnormal_myelination0.73767764
91MP0002132_abnormal_respiratory_system0.73185266
92MP0002009_preneoplasia0.72613348
93MP0004130_abnormal_muscle_cell0.71820565
94MP0001663_abnormal_digestive_system0.70214818
95MP0003566_abnormal_cell_adhesion0.69480489
96MP0000249_abnormal_blood_vessel0.68489670
97MP0005174_abnormal_tail_pigmentation0.67404160
98MP0002019_abnormal_tumor_incidence0.66424604
99MP0001764_abnormal_homeostasis0.65939002
100MP0002138_abnormal_hepatobiliary_system0.63437701
101MP0000604_amyloidosis0.63319376
102MP0008874_decreased_physiological_sensi0.61903026
103MP0000490_abnormal_crypts_of0.60219236
104MP0002254_reproductive_system_inflammat0.60098071
105MP0003329_amyloid_beta_deposits0.59662726
106MP0002332_abnormal_exercise_endurance0.58452024
107MP0003221_abnormal_cardiomyocyte_apopto0.55004108
108MP0001216_abnormal_epidermal_layer0.54684211
109MP0001191_abnormal_skin_condition0.51919237
110MP0009115_abnormal_fat_cell0.48908731
111MP0003091_abnormal_cell_migration0.47412771
112MP0005388_respiratory_system_phenotype0.47078443
113MP0002133_abnormal_respiratory_system0.47078443
114MP0003045_fibrosis0.46548366
115MP0006072_abnormal_retinal_apoptosis0.41972060
116MP0000609_abnormal_liver_physiology0.41658633
117MP0002928_abnormal_bile_duct0.40615292

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.47173408
2Eczematoid dermatitis (HP:0000976)7.37215585
3Recurrent bacterial skin infections (HP:0005406)6.17230375
4Recurrent gram-negative bacterial infections (HP:0005420)5.93411450
5Stomatitis (HP:0010280)5.62152379
6Recurrent fungal infections (HP:0002841)4.85099170
7Myositis (HP:0100614)4.55402067
8Abnormality of macrophages (HP:0004311)4.46849317
9Mediastinal lymphadenopathy (HP:0100721)4.44926371
10Recurrent skin infections (HP:0001581)4.38078141
11Chronic obstructive pulmonary disease (HP:0006510)4.35018702
12Obstructive lung disease (HP:0006536)4.35018702
13Elevated erythrocyte sedimentation rate (HP:0003565)4.25006652
14IgM deficiency (HP:0002850)4.20119897
15Gingivitis (HP:0000230)4.09116298
16Abnormality of glycolipid metabolism (HP:0010969)4.02456780
17Abnormality of liposaccharide metabolism (HP:0010968)4.02456780
18Abnormality of glycosphingolipid metabolism (HP:0004343)4.02456780
19Chronic mucocutaneous candidiasis (HP:0002728)4.00475045
20Recurrent cutaneous fungal infections (HP:0011370)4.00475045
21Orchitis (HP:0100796)3.87071505
22Pustule (HP:0200039)3.65280518
23Recurrent viral infections (HP:0004429)3.45744919
24Gastrointestinal infarctions (HP:0005244)3.45391319
25Retrobulbar optic neuritis (HP:0100654)3.42837791
26Optic neuritis (HP:0100653)3.42837791
27Inflammation of the large intestine (HP:0002037)3.37664677
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.37063810
29Meningitis (HP:0001287)3.33818081
30Abnormality of T cell number (HP:0011839)3.29965462
31T lymphocytopenia (HP:0005403)3.26853490
32Spontaneous hematomas (HP:0007420)3.24191327
33Urticaria (HP:0001025)3.18417908
34Periodontitis (HP:0000704)3.16292850
35Colitis (HP:0002583)3.15776949
36Gastrointestinal inflammation (HP:0004386)3.14088721
37Chronic otitis media (HP:0000389)3.07939316
38Chronic diarrhea (HP:0002028)2.93198381
39Abnormality of T cells (HP:0002843)2.92119782
40Vasculitis (HP:0002633)2.89942795
41Cellulitis (HP:0100658)2.87025496
42Short femoral neck (HP:0100864)2.82321315
43Hepatosplenomegaly (HP:0001433)2.82077415
44Disinhibition (HP:0000734)2.80221469
45Amyloidosis (HP:0011034)2.79331032
46Loss of speech (HP:0002371)2.75154509
47Petechiae (HP:0000967)2.74808760
48Leukocytosis (HP:0001974)2.73458617
49Vacuolated lymphocytes (HP:0001922)2.72319204
50Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.67796087
51Metaphyseal irregularity (HP:0003025)2.66340252
52Keratoconjunctivitis sicca (HP:0001097)2.66147771
53Hematochezia (HP:0002573)2.63884680
54Hemoptysis (HP:0002105)2.63228864
55Lymphopenia (HP:0001888)2.61333642
56Nasal polyposis (HP:0100582)2.59447362
57Pulmonary infiltrates (HP:0002113)2.59194583
58Arterial thrombosis (HP:0004420)2.58876449
59Interstitial pulmonary disease (HP:0006530)2.57883269
60Thickened calvaria (HP:0002684)2.57679049
61Episodic fever (HP:0001954)2.54825263
62Joint swelling (HP:0001386)2.54701685
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.53776399
64Panhypogammaglobulinemia (HP:0003139)2.51713807
65Anorexia (HP:0002039)2.48505259
66Recurrent bronchitis (HP:0002837)2.45990443
67Eosinophilia (HP:0001880)2.45307487
68Cheilitis (HP:0100825)2.44642279
69Encephalitis (HP:0002383)2.44569998
70Abnormality of T cell physiology (HP:0011840)2.43106406
71Purpura (HP:0000979)2.43098726
72Keratoconjunctivitis (HP:0001096)2.39792184
73Recurrent sinusitis (HP:0011108)2.39224977
74Increased IgM level (HP:0003496)2.37642000
75Gangrene (HP:0100758)2.37625578
76Autoimmune hemolytic anemia (HP:0001890)2.34850038
77Severe combined immunodeficiency (HP:0004430)2.32627353
78Skin ulcer (HP:0200042)2.31730985
79Autoimmune thrombocytopenia (HP:0001973)2.31589811
80Polyneuropathy (HP:0001271)2.30644168
81Abnormality of the nasal mucosa (HP:0000433)2.30496342
82Abnormality of the fingertips (HP:0001211)2.24847297
83Combined immunodeficiency (HP:0005387)2.24694921
84Abnormal platelet volume (HP:0011876)2.24039739
85Granulocytopenia (HP:0001913)2.21939185
86Thyroiditis (HP:0100646)2.20631190
87Abnormality of eosinophils (HP:0001879)2.19794725
88IgA deficiency (HP:0002720)2.19642318
89Abnormality of the pleura (HP:0002103)2.19051835
90Pulmonary embolism (HP:0002204)2.17382543
91Systemic lupus erythematosus (HP:0002725)2.16555411
92Epistaxis (HP:0000421)2.16327121
93Recurrent pneumonia (HP:0006532)2.16154698
94Increased serum ferritin (HP:0003281)2.13527296
95Gingival bleeding (HP:0000225)2.12111845
96Aplasia/hypoplasia of the femur (HP:0005613)2.10670850
97Osteomyelitis (HP:0002754)2.08925297
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08390902
99Glomerulopathy (HP:0100820)2.07269189
100Increased IgE level (HP:0003212)2.07089073
101Abnormality of polysaccharide metabolism (HP:0011012)2.05926647
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05926647
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05926647
104Chest pain (HP:0100749)2.05698206
105Prolonged bleeding time (HP:0003010)2.05317419
106Dysostosis multiplex (HP:0000943)2.04929502
107Increased cerebral lipofuscin (HP:0011813)2.02602516
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02433538
109Increased neuronal autofluorescent lipopigment (HP:0002074)2.01241535
110Vertigo (HP:0002321)1.99779499
111Papilledema (HP:0001085)1.98547521
112Verrucae (HP:0200043)1.98173402
113Papilloma (HP:0012740)1.98173402
114Mutism (HP:0002300)1.97148363
115Hypergammaglobulinemia (HP:0010702)1.96514705
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96090932
117Hypochromic anemia (HP:0001931)1.94637804
118IgG deficiency (HP:0004315)1.92959638
119Sepsis (HP:0100806)1.92530029
120Amaurosis fugax (HP:0100576)1.92122439
121Recurrent lower respiratory tract infections (HP:0002783)1.89792143
122Peritonitis (HP:0002586)1.89679285
123Hypochromic microcytic anemia (HP:0004840)1.89502769
124Mucopolysacchariduria (HP:0008155)1.89463687
125Urinary glycosaminoglycan excretion (HP:0003541)1.89463687
126Abnormality of iron homeostasis (HP:0011031)1.87941464
127Thoracic kyphosis (HP:0002942)1.86756947
128Spondylolisthesis (HP:0003302)1.85174112
129Increased density of long bones (HP:0006392)1.84632070
130Vertebral compression fractures (HP:0002953)1.82036973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.07077089
2TXK3.61514584
3STK103.04228996
4ITK2.99564405
5IRAK42.98631602
6MAP2K32.84864703
7TYK22.67519754
8BLK2.66472282
9TEC2.57935323
10ZAP702.52129794
11TGFBR22.41644502
12BTK2.41339378
13CSK2.35982792
14CLK12.31520172
15PRPF4B2.28561797
16EPHB12.20765479
17HCK2.01339766
18IKBKE1.99159664
19ERN11.87862420
20JAK31.84502561
21TRPM71.84497903
22MAP3K31.83542705
23GRK61.80235692
24RIPK41.74675348
25FES1.73980166
26FGFR41.64941400
27TBK11.60071540
28JAK11.58184298
29FGR1.56777379
30RPS6KA41.55368403
31MAP3K141.49716143
32LCK1.39802751
33CAMKK21.38257504
34MAP3K121.30886914
35IRAK31.29193591
36TESK21.28674854
37MATK1.26819464
38LRRK21.26628034
39IKBKB1.22389578
40SYK1.20398313
41YES11.16062883
42KIT1.15980416
43FGFR31.13733313
44CDK121.12985983
45ERBB31.07484872
46BMPR21.04714048
47JAK21.01479708
48IRAK21.00227581
49IRAK10.98603000
50MARK30.96302097
51EEF2K0.95635757
52LYN0.95426012
53PRKCH0.93320609
54CSF1R0.92054015
55KDR0.91904995
56NLK0.91458926
57CDK190.91029484
58SIK30.90774886
59PDPK10.90103299
60TAOK10.88207502
61PKN20.87437966
62TRIB30.85608155
63PIM10.85228502
64PRKG20.84727111
65TTN0.79850942
66MAP3K130.74681163
67PIK3CG0.74522806
68PTK60.72240844
69TNK20.71958567
70PRKCQ0.71241840
71MST40.71202105
72TAOK20.71177551
73KSR20.69820606
74CAMK1D0.69153947
75CAMKK10.66980790
76PAK40.66780283
77PTK20.64347693
78MAP3K110.64295265
79ACVR1B0.63595341
80MARK20.63263540
81RAF10.63189352
82GRK70.62948268
83MAP3K90.59220650
84MAP3K20.58277875
85MAP2K60.57547165
86CDC42BPA0.55900735
87MAPKAPK20.54476421
88CHUK0.53932259
89MAP3K50.53269832
90FYN0.52814191
91GRK10.52125343
92SGK30.50659226
93PRKD20.50577102
94CDK90.50426355
95ALK0.49972955
96DMPK0.48787400
97MOS0.46669676
98MAPK70.46003868
99EGFR0.45785769
100RPS6KA60.45763221
101DAPK20.44568808
102FGFR10.44314975
103STK110.43942902
104MAPK40.43697658
105MAP3K60.43045149
106SIK20.42431755
107STK240.42392551
108SGK20.41822373
109MAP3K100.41622532
110KSR10.41610948
111PRKCD0.41031310
112CDK60.38716939
113TAOK30.38592949
114PDK10.38400868
115HIPK20.38022153
116IGF1R0.37449822
117DYRK1B0.36547828
118STK40.36214817
119SMG10.33571139
120NUAK10.33245409
121MAP3K70.33043468
122MAP3K80.32103750
123MELK0.31723831
124BRD40.31478037
125RPS6KL10.29805479
126RPS6KC10.29805479
127CAMK40.28670321
128EPHA30.28664699
129MAPK110.26427426
130MAPK120.26319157
131MAP3K10.25511231
132NEK90.25317324
133ABL10.25009614

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.40029158
2Staphylococcus aureus infection_Homo sapiens_hsa051503.33810204
3Primary immunodeficiency_Homo sapiens_hsa053402.98712645
4Osteoclast differentiation_Homo sapiens_hsa043802.76655330
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63984845
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.54308392
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.42905071
8T cell receptor signaling pathway_Homo sapiens_hsa046602.36707461
9Leukocyte transendothelial migration_Homo sapiens_hsa046702.35185689
10Hematopoietic cell lineage_Homo sapiens_hsa046402.34768194
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.22828394
12Measles_Homo sapiens_hsa051622.12917300
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.11737390
14Asthma_Homo sapiens_hsa053102.11379752
15B cell receptor signaling pathway_Homo sapiens_hsa046622.02754619
16Graft-versus-host disease_Homo sapiens_hsa053321.88518240
17Chemokine signaling pathway_Homo sapiens_hsa040621.87874983
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77651807
19Tuberculosis_Homo sapiens_hsa051521.72532994
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.71594435
21Pertussis_Homo sapiens_hsa051331.71375997
22Shigellosis_Homo sapiens_hsa051311.68095032
23TNF signaling pathway_Homo sapiens_hsa046681.59930195
24Viral myocarditis_Homo sapiens_hsa054161.56828274
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.55982877
26Hepatitis B_Homo sapiens_hsa051611.53738768
27Legionellosis_Homo sapiens_hsa051341.52247468
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50749002
29Toxoplasmosis_Homo sapiens_hsa051451.49401947
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48202227
31Antigen processing and presentation_Homo sapiens_hsa046121.44919018
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44105673
33Other glycan degradation_Homo sapiens_hsa005111.41363931
34Herpes simplex infection_Homo sapiens_hsa051681.40994190
35Salmonella infection_Homo sapiens_hsa051321.39866736
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37998113
37Caffeine metabolism_Homo sapiens_hsa002321.30712501
38Malaria_Homo sapiens_hsa051441.28101118
39Influenza A_Homo sapiens_hsa051641.27701295
40Pancreatic cancer_Homo sapiens_hsa052121.27240770
41Acute myeloid leukemia_Homo sapiens_hsa052211.27185471
42Allograft rejection_Homo sapiens_hsa053301.24627860
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20007374
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18957852
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13716175
46Apoptosis_Homo sapiens_hsa042101.10687737
47Platelet activation_Homo sapiens_hsa046111.10632047
48Chronic myeloid leukemia_Homo sapiens_hsa052201.01864700
49Rheumatoid arthritis_Homo sapiens_hsa053230.97234373
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95799440
51VEGF signaling pathway_Homo sapiens_hsa043700.95578499
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93547464
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92256173
54Bladder cancer_Homo sapiens_hsa052190.88003679
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.86772675
56Hepatitis C_Homo sapiens_hsa051600.85838424
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84607671
58Autoimmune thyroid disease_Homo sapiens_hsa053200.81531953
59Prolactin signaling pathway_Homo sapiens_hsa049170.81235282
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.80962682
61Phagosome_Homo sapiens_hsa041450.79459421
62Lysosome_Homo sapiens_hsa041420.72930271
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72461070
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71388414
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70998678
66Non-small cell lung cancer_Homo sapiens_hsa052230.69560046
67Epstein-Barr virus infection_Homo sapiens_hsa051690.67532911
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.67072134
69Insulin resistance_Homo sapiens_hsa049310.64832703
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63630072
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63527692
72Endocytosis_Homo sapiens_hsa041440.61993977
73Collecting duct acid secretion_Homo sapiens_hsa049660.60424313
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60209232
75HTLV-I infection_Homo sapiens_hsa051660.59760780
76Colorectal cancer_Homo sapiens_hsa052100.59289434
77Amoebiasis_Homo sapiens_hsa051460.58057684
78Dorso-ventral axis formation_Homo sapiens_hsa043200.51648235
79GnRH signaling pathway_Homo sapiens_hsa049120.49667932
80FoxO signaling pathway_Homo sapiens_hsa040680.49160345
81mTOR signaling pathway_Homo sapiens_hsa041500.48781881
82Viral carcinogenesis_Homo sapiens_hsa052030.48493476
83Type I diabetes mellitus_Homo sapiens_hsa049400.48262279
84Rap1 signaling pathway_Homo sapiens_hsa040150.48087054
85Endometrial cancer_Homo sapiens_hsa052130.44868866
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44227457
87Pentose phosphate pathway_Homo sapiens_hsa000300.44179309
88Proteoglycans in cancer_Homo sapiens_hsa052050.43301109
89MAPK signaling pathway_Homo sapiens_hsa040100.42436341
90Choline metabolism in cancer_Homo sapiens_hsa052310.41503632
91p53 signaling pathway_Homo sapiens_hsa041150.40661208
92Type II diabetes mellitus_Homo sapiens_hsa049300.38957915
93Adherens junction_Homo sapiens_hsa045200.38637500
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37953512
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37630009
96Inositol phosphate metabolism_Homo sapiens_hsa005620.36288691
97Galactose metabolism_Homo sapiens_hsa000520.35709408
98Renal cell carcinoma_Homo sapiens_hsa052110.34309972
99Regulation of autophagy_Homo sapiens_hsa041400.33247586
100Pathways in cancer_Homo sapiens_hsa052000.32523821
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32307916
102MicroRNAs in cancer_Homo sapiens_hsa052060.31457135
103HIF-1 signaling pathway_Homo sapiens_hsa040660.31443277
104Small cell lung cancer_Homo sapiens_hsa052220.30040179
105Estrogen signaling pathway_Homo sapiens_hsa049150.29942781
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.28955351
107African trypanosomiasis_Homo sapiens_hsa051430.27334986
108Complement and coagulation cascades_Homo sapiens_hsa046100.25351945
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24756698
110Focal adhesion_Homo sapiens_hsa045100.22702384
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.20661971
112Notch signaling pathway_Homo sapiens_hsa043300.20507546
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.18533043
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18099728

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