CD109

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.42742612
2desmosome organization (GO:0002934)5.79092918
3hemidesmosome assembly (GO:0031581)5.47497836
4chondrocyte proliferation (GO:0035988)5.45517296
5cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.32814139
6chondrocyte development (GO:0002063)5.30786661
7endodermal cell differentiation (GO:0035987)4.79328587
8skin morphogenesis (GO:0043589)4.67946420
9notochord development (GO:0030903)4.66704639
10keratan sulfate catabolic process (GO:0042340)4.43633279
11protein localization to endosome (GO:0036010)4.43117445
12substrate-dependent cell migration (GO:0006929)4.33893205
13positive regulation of extracellular matrix organization (GO:1903055)4.30937414
14protein heterotrimerization (GO:0070208)4.27237678
15collagen metabolic process (GO:0032963)4.22024609
16collagen catabolic process (GO:0030574)4.20741666
17cellular response to vitamin (GO:0071295)4.17696708
18cartilage condensation (GO:0001502)4.13495515
19cell aggregation (GO:0098743)4.13495515
20plasma membrane repair (GO:0001778)3.96717185
21hypotonic response (GO:0006971)3.96002421
22endothelial cell morphogenesis (GO:0001886)3.94817651
23multicellular organismal macromolecule metabolic process (GO:0044259)3.93184947
24basement membrane organization (GO:0071711)3.86386364
25multicellular organismal catabolic process (GO:0044243)3.83086778
26peptidyl-proline hydroxylation (GO:0019511)3.82803513
27membrane raft organization (GO:0031579)3.81380486
28extracellular matrix disassembly (GO:0022617)3.79215307
29dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.79121584
30sequestering of extracellular ligand from receptor (GO:0035581)3.75579173
31multicellular organismal metabolic process (GO:0044236)3.69947400
32keratinocyte proliferation (GO:0043616)3.64284219
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.57657685
34negative regulation of chondrocyte differentiation (GO:0032331)3.57063517
35cell adhesion mediated by integrin (GO:0033627)3.56075508
36limb bud formation (GO:0060174)3.55353547
37axon extension involved in axon guidance (GO:0048846)3.51625036
38neuron projection extension involved in neuron projection guidance (GO:1902284)3.51625036
39negative regulation of keratinocyte proliferation (GO:0010839)3.49334059
40positive regulation of osteoblast proliferation (GO:0033690)3.47135146
41regulation of membrane protein ectodomain proteolysis (GO:0051043)3.43674366
42positive regulation of endothelial cell apoptotic process (GO:2000353)3.41757547
43regulation of early endosome to late endosome transport (GO:2000641)3.39297067
44dermatan sulfate biosynthetic process (GO:0030208)3.37154573
45bone trabecula formation (GO:0060346)3.33683341
46retina vasculature morphogenesis in camera-type eye (GO:0061299)3.33058315
47mesenchymal-epithelial cell signaling (GO:0060638)3.30138570
48negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.29823369
49embryonic skeletal joint morphogenesis (GO:0060272)3.27315287
50epithelial cell-cell adhesion (GO:0090136)3.26989150
51blood vessel maturation (GO:0001955)3.26785104
52wound healing, spreading of epidermal cells (GO:0035313)3.25958286
53negative regulation of fatty acid transport (GO:2000192)3.20910631
54positive regulation of macrophage activation (GO:0043032)3.20657117
55glomerular basement membrane development (GO:0032836)3.19154998
56Golgi transport vesicle coating (GO:0048200)3.17925839
57COPI coating of Golgi vesicle (GO:0048205)3.17925839
58hippo signaling (GO:0035329)3.17219379
59protein hydroxylation (GO:0018126)3.15999598
60regulation of phospholipase A2 activity (GO:0032429)3.12791642
61hyaluronan catabolic process (GO:0030214)3.12732133
62cell-substrate junction assembly (GO:0007044)3.12648997
63cell migration involved in heart development (GO:0060973)3.11678036
64cellular response to interferon-alpha (GO:0035457)3.08326611
65peptide cross-linking (GO:0018149)3.08141911
66regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.06644625
67regulation of integrin-mediated signaling pathway (GO:2001044)3.06622793
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.03880318
69extracellular matrix organization (GO:0030198)3.03867002
70barbed-end actin filament capping (GO:0051016)3.03298857
71keratinocyte differentiation (GO:0030216)3.03211374
72extracellular structure organization (GO:0043062)3.02771654
73regulation of vitamin D biosynthetic process (GO:0060556)3.01866260
74positive regulation of blood vessel endothelial cell migration (GO:0043536)3.01849822
75response to vitamin D (GO:0033280)2.99945910
76negative regulation of cartilage development (GO:0061037)2.99896586
77endothelium development (GO:0003158)2.99870252
78regulation of transforming growth factor beta1 production (GO:0032908)2.99726720
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.99104030
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98672192
81dermatan sulfate metabolic process (GO:0030205)2.98564263
82protein localization to cell surface (GO:0034394)2.96677393
83planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96093641
84negative regulation of nitric oxide biosynthetic process (GO:0045019)2.95689383
85heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.94903706
86positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.94745601
87chondroitin sulfate biosynthetic process (GO:0030206)2.94233710
88negative regulation of anoikis (GO:2000811)2.94022983
89glomerular visceral epithelial cell development (GO:0072015)2.91923459
90virion attachment to host cell (GO:0019062)2.91070222
91adhesion of symbiont to host cell (GO:0044650)2.91070222
92negative regulation of catenin import into nucleus (GO:0035414)2.90906713
93cartilage development (GO:0051216)2.89950149
94G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.89884116
95sprouting angiogenesis (GO:0002040)2.89478508
96endochondral ossification (GO:0001958)2.89242972
97replacement ossification (GO:0036075)2.89242972
98cell migration involved in sprouting angiogenesis (GO:0002042)2.88880791
99positive regulation of cartilage development (GO:0061036)2.88235354
100regulation of metalloenzyme activity (GO:0048552)2.86904060
101regulation of extracellular matrix disassembly (GO:0010715)2.86865850
102outer ear morphogenesis (GO:0042473)2.84417233
103regulation of transforming growth factor beta2 production (GO:0032909)2.84070975
104glomerular epithelial cell development (GO:0072310)2.83867905
105extracellular matrix assembly (GO:0085029)2.83630479
106wound healing, spreading of cells (GO:0044319)2.82043730
107protein retention in ER lumen (GO:0006621)2.82007691
108regulation of heart morphogenesis (GO:2000826)2.81412807
109cellular response to vitamin D (GO:0071305)2.79609444
110neural crest cell development (GO:0014032)2.79532799
111wound healing (GO:0042060)2.79236349
112positive regulation of mesenchymal cell proliferation (GO:0002053)2.78895877
113type B pancreatic cell proliferation (GO:0044342)2.78669218
114mammary gland epithelial cell proliferation (GO:0033598)2.78599446
115regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77672385
116regulation of chondrocyte differentiation (GO:0032330)2.77399811
117vascular endothelial growth factor signaling pathway (GO:0038084)2.76906183
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.76371342
119regulation of cartilage development (GO:0061035)2.75986447
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74429397
121establishment of skin barrier (GO:0061436)2.73844891
122stress fiber assembly (GO:0043149)2.73560500
123gap junction assembly (GO:0016264)2.73377126
124lymphangiogenesis (GO:0001946)2.72971177
125lymph vessel development (GO:0001945)2.72618428
126glycosaminoglycan catabolic process (GO:0006027)2.72103218
127mesodermal cell differentiation (GO:0048333)2.71747959
128substrate adhesion-dependent cell spreading (GO:0034446)2.70617568
129vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.70311613
130negative regulation of nitric-oxide synthase activity (GO:0051001)2.69281692
131regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68067595
132regulation of water loss via skin (GO:0033561)2.67626710
133embryonic cranial skeleton morphogenesis (GO:0048701)2.67258685
134regulation of SMAD protein import into nucleus (GO:0060390)2.67076715
135polarized epithelial cell differentiation (GO:0030859)2.66145589
136regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65867279
137apoptotic cell clearance (GO:0043277)2.65705846
138aminoglycan catabolic process (GO:0006026)2.64966226
139adhesion of symbiont to host (GO:0044406)2.64635612
140embryonic viscerocranium morphogenesis (GO:0048703)2.64319513
141regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.63836456
142positive regulation of epithelial to mesenchymal transition (GO:0010718)2.63350365
143epithelial to mesenchymal transition (GO:0001837)2.61568854
144glomerular filtration (GO:0003094)2.61265943
145regulation of cell fate specification (GO:0042659)2.61258500
146membrane protein ectodomain proteolysis (GO:0006509)2.60680837
147negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.59214272
148negative regulation of adherens junction organization (GO:1903392)2.59004898
149negative regulation of focal adhesion assembly (GO:0051895)2.59004898
150negative regulation of cell junction assembly (GO:1901889)2.59004898
151decidualization (GO:0046697)2.58863777
152renal filtration (GO:0097205)2.58575282
153regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56376469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.40642863
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.66576862
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.98101374
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.81686023
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.77013839
6* CJUN_26792858_Chip-Seq_BT549_Human2.52419193
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46897040
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.45645393
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.36126082
10SOX9_24532713_ChIP-Seq_HFSC_Mouse2.35925098
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.34707124
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.31076380
13* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.31076380
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.22979366
15CLOCK_20551151_ChIP-Seq_293T_Human2.17924719
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.13585293
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.10829003
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.04716547
19AR_21572438_ChIP-Seq_LNCaP_Human2.02196927
20TP63_17297297_ChIP-ChIP_HaCaT_Human11.3657297
21* BRD4_25478319_ChIP-Seq_HGPS_Human1.95802814
22* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.94240582
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85716016
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.81275745
25P63_26484246_Chip-Seq_KERATINOCYTES_Human1.74862442
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70668168
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69859132
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69859132
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69291198
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.65043491
31* TP53_18474530_ChIP-ChIP_U2OS_Human1.64911471
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.60385272
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.58657597
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58545297
35TP53_16413492_ChIP-PET_HCT116_Human1.58410501
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56558296
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54628285
38* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53617327
39* SOX2_20726797_ChIP-Seq_SW620_Human1.53119963
40* UBF1/2_26484160_Chip-Seq_HMECs_Human1.52801639
41* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49891809
42* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49348922
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49276123
44* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.47142146
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43089790
46ATF3_27146783_Chip-Seq_COLON_Human1.39132630
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.39102673
48* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38424985
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36459756
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33404799
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.27455711
52ZNF263_19887448_ChIP-Seq_K562_Human1.26894683
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24004126
54SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22891933
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.21972401
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21483549
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19889637
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17458281
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16875621
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16319628
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14452075
62RXR_22108803_ChIP-Seq_LS180_Human1.12557673
63KLF5_25053715_ChIP-Seq_YYC3_Human1.11751948
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10746472
65* TP63_23658742_ChIP-Seq_EP156T_Human1.10423541
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.06951623
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05640466
68TP53_22127205_ChIP-Seq_IMR90_Human1.05400453
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03803185
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03693926
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03589027
72* TP53_23651856_ChIP-Seq_MEFs_Mouse1.03581127
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02369523
74RACK7_27058665_Chip-Seq_MCF-7_Human1.02152121
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01270202
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01200569
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00099254
78TBX20_22328084_ChIP-Seq_HEART_Mouse0.98069375
79TBX20_22080862_ChIP-Seq_HEART_Mouse0.98069375
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97546855
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97086523
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97004079
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96529760
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94739519
85* GATA3_24758297_ChIP-Seq_MCF-7_Human0.93843810
86CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92086124
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91878501
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.91291425
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90317706
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89925933
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89529958
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88620474
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88490945
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86324626
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.85281368
96* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82322007
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80333029
98RUNX1_27514584_Chip-Seq_MCF-7_Human0.80037910
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.79912846
100* GATA2_21666600_ChIP-Seq_HMVEC_Human0.79199191
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78863409
102SA1_22415368_ChIP-Seq_MEFs_Mouse0.78854660
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78736773
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.78024370
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77925425
106AR_21909140_ChIP-Seq_LNCAP_Human0.76721000
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76047727
108FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74485035
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74394559
110ISL1_27105846_Chip-Seq_CPCs_Mouse0.74321887
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.73941861
112BCAT_22108803_ChIP-Seq_LS180_Human0.73886250
113TFEB_21752829_ChIP-Seq_HELA_Human0.73734555
114* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73551794
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.73021138
116MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.72233772
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71332997
118IRF8_27001747_Chip-Seq_BMDM_Mouse0.70080555
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.69976948
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69295365
121VDR_24787735_ChIP-Seq_THP-1_Human0.68863729
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.68663744
123AHR_22903824_ChIP-Seq_MCF-7_Human0.67841495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.58200311
2MP0005275_abnormal_skin_tensile5.13258836
3MP0003705_abnormal_hypodermis_morpholog4.28986322
4MP0005503_abnormal_tendon_morphology3.65181333
5MP0004272_abnormal_basement_membrane2.64938731
6MP0002282_abnormal_trachea_morphology2.62689726
7MP0002060_abnormal_skin_morphology2.60878743
8MP0003941_abnormal_skin_development2.56072031
9MP0003279_aneurysm2.54105666
10MP0003566_abnormal_cell_adhesion2.48574967
11MP0005623_abnormal_meninges_morphology2.48078847
12MP0002796_impaired_skin_barrier2.38142269
13MP0010352_gastrointestinal_tract_polyps2.37580699
14MP0009384_cardiac_valve_regurgitation2.24638216
15MP0009250_abnormal_appendicular_skeleto2.21348223
16MP0001958_emphysema2.17087274
17MP0002877_abnormal_melanocyte_morpholog2.09183750
18MP0005508_abnormal_skeleton_morphology2.04544175
19MP0010030_abnormal_orbit_morphology2.04003652
20MP0000762_abnormal_tongue_morphology1.94486025
21MP0005023_abnormal_wound_healing1.86614425
22MP0003191_abnormal_cellular_cholesterol1.83979469
23MP0010234_abnormal_vibrissa_follicle1.81721693
24MP0002896_abnormal_bone_mineralization1.81168908
25MP0006054_spinal_hemorrhage1.79454587
26MP0004134_abnormal_chest_morphology1.74461379
27MP0000163_abnormal_cartilage_morphology1.70326136
28MP0003828_pulmonary_edema1.70313762
29MP0005501_abnormal_skin_physiology1.70219305
30MP0003091_abnormal_cell_migration1.66588059
31MP0002933_joint_inflammation1.65845833
32MP0001542_abnormal_bone_strength1.62994160
33MP0001299_abnormal_eye_distance/1.62377185
34MP0005409_darkened_coat_color1.61945096
35MP0005257_abnormal_intraocular_pressure1.61261035
36MP0002254_reproductive_system_inflammat1.54524741
37MP0002115_abnormal_skeleton_extremities1.51626450
38MP0001243_abnormal_dermal_layer1.48150819
39MP0000467_abnormal_esophagus_morphology1.44443849
40MP0000678_abnormal_parathyroid_gland1.42620716
41MP0003950_abnormal_plasma_membrane1.40969071
42MP0003755_abnormal_palate_morphology1.39894928
43MP0003453_abnormal_keratinocyte_physiol1.39546721
44MP0001216_abnormal_epidermal_layer1.38477088
45MP0003385_abnormal_body_wall1.37159605
46MP0009053_abnormal_anal_canal1.36901994
47MP0000733_abnormal_muscle_development1.36105114
48MP0004084_abnormal_cardiac_muscle1.35500273
49MP0002249_abnormal_larynx_morphology1.33504054
50MP0010771_integument_phenotype1.32597218
51MP0005165_increased_susceptibility_to1.30702367
52MP0000383_abnormal_hair_follicle1.30393999
53MP0002089_abnormal_postnatal_growth/wei1.29521543
54MP0005390_skeleton_phenotype1.29037712
55MP0002113_abnormal_skeleton_development1.28209389
56MP0001849_ear_inflammation1.26947109
57MP0009379_abnormal_foot_pigmentation1.25837393
58MP0003448_altered_tumor_morphology1.23151318
59MP0002108_abnormal_muscle_morphology1.22540008
60MP0010678_abnormal_skin_adnexa1.16018570
61MP0000579_abnormal_nail_morphology1.13778989
62MP0005595_abnormal_vascular_smooth1.13539536
63MP0000377_abnormal_hair_follicle1.13379904
64MP0000432_abnormal_head_morphology1.12256267
65MP0005164_abnormal_response_to1.12114404
66MP0001915_intracranial_hemorrhage1.11984245
67MP0000049_abnormal_middle_ear1.11015770
68MP0002109_abnormal_limb_morphology1.09473539
69MP0000428_abnormal_craniofacial_morphol1.08925174
70MP0005076_abnormal_cell_differentiation1.08606642
71MP0000647_abnormal_sebaceous_gland1.05569563
72MP0005197_abnormal_uvea_morphology1.05409474
73MP0003937_abnormal_limbs/digits/tail_de1.01410119
74MP0000427_abnormal_hair_cycle1.00353770
75MP0008004_abnormal_stomach_pH0.99722274
76MP0003942_abnormal_urinary_system0.99484786
77MP0002098_abnormal_vibrissa_morphology0.99299261
78MP0000767_abnormal_smooth_muscle0.98231120
79MP0002233_abnormal_nose_morphology0.98126518
80MP0002295_abnormal_pulmonary_circulatio0.98091541
81MP0003045_fibrosis0.97273094
82MP0003935_abnormal_craniofacial_develop0.96728788
83MP0000013_abnormal_adipose_tissue0.96679998
84MP0003795_abnormal_bone_structure0.95908359
85MP0000569_abnormal_digit_pigmentation0.94469680
86MP0001533_abnormal_skeleton_physiology0.94084627
87MP0005367_renal/urinary_system_phenotyp0.94079173
88MP0000516_abnormal_urinary_system0.94079173
89MP0002998_abnormal_bone_remodeling0.93062208
90MP0002116_abnormal_craniofacial_bone0.91962002
91MP0000750_abnormal_muscle_regeneration0.90920503
92MP0002111_abnormal_tail_morphology0.90821500
93MP0002234_abnormal_pharynx_morphology0.89079927
94MP0005058_abnormal_lysosome_morphology0.88594284
95MP0000537_abnormal_urethra_morphology0.88369092
96MP0002009_preneoplasia0.88270335
97MP0000627_abnormal_mammary_gland0.87489781
98MP0006138_congestive_heart_failure0.87218262
99MP0009780_abnormal_chondrocyte_physiolo0.87201404
100MP0003283_abnormal_digestive_organ0.85656666
101MP0002932_abnormal_joint_morphology0.85654249
102MP0001879_abnormal_lymphatic_vessel0.84318118
103MP0001191_abnormal_skin_condition0.84120506
104MP0001346_abnormal_lacrimal_gland0.83858596
105MP0000858_altered_metastatic_potential0.83607945
106MP0004947_skin_inflammation0.83431697
107MP0000534_abnormal_ureter_morphology0.82913113
108MP0009840_abnormal_foam_cell0.82528350
109MP0003136_yellow_coat_color0.82477796
110MP0002177_abnormal_outer_ear0.81187702
111MP0010368_abnormal_lymphatic_system0.79461249
112MP0003300_gastrointestinal_ulcer0.78471412
113MP0004185_abnormal_adipocyte_glucose0.75505830
114MP0001348_abnormal_lacrimal_gland0.74896929
115MP0002168_other_aberrant_phenotype0.74833020
116MP0005171_absent_coat_pigmentation0.74473639
117MP0001340_abnormal_eyelid_morphology0.73556741
118MP0004197_abnormal_fetal_growth/weight/0.73344344
119MP0009931_abnormal_skin_appearance0.72984584
120MP0001270_distended_abdomen0.72214726
121MP0001614_abnormal_blood_vessel0.71254511
122MP0000343_altered_response_to0.70362578
123MP0000003_abnormal_adipose_tissue0.69923278
124MP0005193_abnormal_anterior_eye0.69647107
125MP0005621_abnormal_cell_physiology0.66622009
126MP0001881_abnormal_mammary_gland0.66321002
127MP0004858_abnormal_nervous_system0.66027378
128MP0005360_urolithiasis0.65391544
129MP0004233_abnormal_muscle_weight0.65373040
130MP0004036_abnormal_muscle_relaxation0.64679833
131MP0004484_altered_response_of0.62468445
132MP0005451_abnormal_body_composition0.62145935
133MP0001851_eye_inflammation0.62059447
134MP0005388_respiratory_system_phenotype0.60555894
135MP0002133_abnormal_respiratory_system0.60555894

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.87772386
2Protrusio acetabuli (HP:0003179)5.37947672
3Neonatal short-limb short stature (HP:0008921)4.88340797
4Epiphyseal dysplasia (HP:0002656)4.57291384
5Onycholysis (HP:0001806)4.56246239
6Cervical subluxation (HP:0003308)4.20619836
7Cupped ribs (HP:0000887)4.09246959
8Hypoplastic ischia (HP:0003175)3.94692081
9Atrophic scars (HP:0001075)3.81537019
10Vitreoretinal degeneration (HP:0000655)3.77263700
11Irregular epiphyses (HP:0010582)3.60476093
12Plantar hyperkeratosis (HP:0007556)3.49590267
13Arterial tortuosity (HP:0005116)3.46704491
14Abnormality of the ischium (HP:0003174)3.45759112
15Ankle contracture (HP:0006466)3.36261143
16Thick nail (HP:0001805)3.35125452
17Flat acetabular roof (HP:0003180)3.29832077
18Alopecia of scalp (HP:0002293)3.29074094
19Shallow orbits (HP:0000586)3.19430549
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.12183714
21Absent frontal sinuses (HP:0002688)3.05159929
22Spondylolisthesis (HP:0003302)3.02370949
23Aortic dissection (HP:0002647)3.01576208
24Abnormality of dentin (HP:0010299)2.99518738
25Abnormality of nail color (HP:0100643)2.93202564
26Soft skin (HP:0000977)2.91072317
27Fragile skin (HP:0001030)2.90029558
28Follicular hyperkeratosis (HP:0007502)2.87483661
29Spinal rigidity (HP:0003306)2.77995247
30Wormian bones (HP:0002645)2.76555787
31Nail dystrophy (HP:0008404)2.76242088
32Peritonitis (HP:0002586)2.73634696
33Osteoarthritis (HP:0002758)2.70534403
34Radial bowing (HP:0002986)2.68980839
35Coxa vara (HP:0002812)2.65850836
36Increased connective tissue (HP:0009025)2.64044753
37Abnormal vertebral ossification (HP:0100569)2.61779816
38Genu recurvatum (HP:0002816)2.59958232
39Mesomelia (HP:0003027)2.57528905
40Dilatation of the ascending aorta (HP:0005111)2.57463913
41Ulnar bowing (HP:0003031)2.55236837
42Cardiovascular calcification (HP:0011915)2.49941682
43Short nail (HP:0001799)2.49207273
44Vertebral hypoplasia (HP:0008417)2.47321427
45Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.47321427
46Abnormal tarsal ossification (HP:0008369)2.46520303
47Abnormality of the acetabulum (HP:0003170)2.46510979
48Palmoplantar hyperkeratosis (HP:0000972)2.45121828
49Blue sclerae (HP:0000592)2.44058147
50Aortic aneurysm (HP:0004942)2.41013351
51Tibial bowing (HP:0002982)2.39872150
52Reduced subcutaneous adipose tissue (HP:0003758)2.39672922
53Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.39486821
54Mitral valve prolapse (HP:0001634)2.38188654
55Ridged nail (HP:0001807)2.37854476
56Osteolytic defects of the hand bones (HP:0009699)2.37135745
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.37135745
58Mild short stature (HP:0003502)2.36465671
59Palmar hyperkeratosis (HP:0010765)2.35448323
60Ankyloglossia (HP:0010296)2.34221472
61Selective tooth agenesis (HP:0001592)2.32584310
62Flat capital femoral epiphysis (HP:0003370)2.32149202
63Spinal cord compression (HP:0002176)2.31816158
64Small epiphyses (HP:0010585)2.30624942
65Abnormality of the 2nd finger (HP:0004100)2.29947442
66Type 1 muscle fiber predominance (HP:0003803)2.29233980
67Abnormal foot bone ossification (HP:0010675)2.28882917
68Delayed epiphyseal ossification (HP:0002663)2.25563396
69Broad metatarsal (HP:0001783)2.24480142
70Platyspondyly (HP:0000926)2.23266995
71Entropion (HP:0000621)2.21699632
72Vertebral compression fractures (HP:0002953)2.20280049
73Natal tooth (HP:0000695)2.19994288
74Cerebral aneurysm (HP:0004944)2.19837422
75Thin ribs (HP:0000883)2.19660193
76Abnormality of oral frenula (HP:0000190)2.18804622
77Hypoplasia of dental enamel (HP:0006297)2.17729497
78Spinal cord lesions (HP:0100561)2.17639493
79Syringomyelia (HP:0003396)2.17639493
80Wide anterior fontanel (HP:0000260)2.16739995
81Mitral stenosis (HP:0001718)2.15484269
82Bladder diverticulum (HP:0000015)2.14056431
83Genu varum (HP:0002970)2.13928627
84Metaphyseal cupping (HP:0003021)2.13225273
85Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10881572
86Elbow flexion contracture (HP:0002987)2.10196567
87Pterygium (HP:0001059)2.10167339
88Vascular tortuosity (HP:0004948)2.09592428
89Fibular hypoplasia (HP:0003038)2.08960188
90Broad long bones (HP:0005622)2.07649536
91Bowing of the arm (HP:0006488)2.07363447
92Bowed forearm bones (HP:0003956)2.07363447
93Abnormality of the proximal phalanges of the hand (HP:0009834)2.06885862
94Right ventricular cardiomyopathy (HP:0011663)2.06664576
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.06314869
96Abnormality of glycolipid metabolism (HP:0010969)2.06314869
97Abnormality of liposaccharide metabolism (HP:0010968)2.06314869
98Abnormal blistering of the skin (HP:0008066)2.06163369
99Thoracolumbar scoliosis (HP:0002944)2.05284613
100Advanced eruption of teeth (HP:0006288)2.04540597
101Aplasia cutis congenita (HP:0001057)2.03722559
102Aortic regurgitation (HP:0001659)2.03404519
103Abnormality of the frontal sinuses (HP:0002687)2.03325288
104Flattened epiphyses (HP:0003071)2.02987083
105Hip contracture (HP:0003273)2.01095119
106Stillbirth (HP:0003826)2.00600831
107Glossoptosis (HP:0000162)2.00172623
108Overgrowth (HP:0001548)1.98058042
109Abnormality of carpal bone ossification (HP:0006257)1.97751889
110Beaking of vertebral bodies (HP:0004568)1.96163118
111Hypotrichosis (HP:0001006)1.95705484
112Abnormality of the distal phalanges of the toes (HP:0010182)1.95320507
113Abnormality of the calcaneus (HP:0008364)1.95086152
114Limited elbow extension (HP:0001377)1.93106547
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92169472
116Milia (HP:0001056)1.91974830
117Abnormal delivery (HP:0001787)1.91789462
118Vertebral clefting (HP:0008428)1.90732396
119Joint laxity (HP:0001388)1.89524729
120Vascular calcification (HP:0004934)1.89264206
121Mildly elevated creatine phosphokinase (HP:0008180)1.89044546
122Hypoplasia of the odontoid process (HP:0003311)1.88707023
123Abnormal ossification of hand bones (HP:0005921)1.88513331
124Hypoplastic scapulae (HP:0000882)1.88267048
125Aplasia/Hypoplasia of the scapulae (HP:0006713)1.88267048
126Limited hip movement (HP:0008800)1.87703604
127Ovoid vertebral bodies (HP:0003300)1.87484398
128Fragile nails (HP:0001808)1.87472891
129Wrist flexion contracture (HP:0001239)1.86802401
130Thin bony cortex (HP:0002753)1.86462184
131Broad phalanx (HP:0006009)1.86445078
132Femoral bowing (HP:0002980)1.86349033
133Distal lower limb muscle weakness (HP:0009053)1.85397625
134Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84909147
135Hypoplasia of the iris (HP:0007676)1.82131779
136Slender build (HP:0001533)1.80982428
137Mitral regurgitation (HP:0001653)1.75774475
138Generalized amyotrophy (HP:0003700)1.74372994
139Aneurysm (HP:0002617)1.74043953
140Aortic valve stenosis (HP:0001650)1.73886499
141Delayed closure of the anterior fontanelle (HP:0001476)1.73633147
142Delayed cranial suture closure (HP:0000270)1.73264750
143Coronal craniosynostosis (HP:0004440)1.72890947
144Hyperextensible skin (HP:0000974)1.70255785
145Joint stiffness (HP:0001387)1.67961882
146Nuclear cataract (HP:0100018)1.67926684
147Distal upper limb amyotrophy (HP:0007149)1.66538132
148Upper limb amyotrophy (HP:0009129)1.66538132
149Thin skin (HP:0000963)1.64748332
150Distal lower limb amyotrophy (HP:0008944)1.63537652
151Tetraparesis (HP:0002273)1.63366989
152Protruding ear (HP:0000411)1.62888190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.99582886
2TTN3.50034465
3LATS13.35165437
4MAP3K33.21951960
5TRPM72.99240466
6TRIB32.95857996
7EEF2K2.90426409
8MST1R2.83383372
9EPHB22.73009742
10IRAK32.37059864
11PKN22.35698188
12PIM22.23951463
13MYLK2.09492832
14PAK22.06606797
15ERBB32.03530355
16NTRK12.02115479
17PDGFRA2.01755946
18FER2.01305734
19MET1.93948185
20LATS21.93860911
21SIK31.93585018
22MAPKAPK31.93263086
23TIE11.88548840
24LRRK21.87973768
25BMX1.66668362
26STK38L1.65024242
27MOS1.62213821
28FLT31.56718267
29STK31.50366775
30TESK11.50112353
31PTK61.39120789
32LMTK21.37093270
33EPHA31.36525236
34ERN11.36116420
35BCR1.34706754
36FGFR11.34172951
37RPS6KA41.30179570
38ARAF1.27619988
39PTK21.27498865
40SIK11.26421288
41LIMK11.24466330
42TRIM281.21582694
43ROCK11.17309601
44STK241.14964314
45EIF2AK31.13415342
46EPHA21.10131782
47PAK31.07648631
48MAP3K141.04714648
49RPS6KB21.04357804
50NME21.02339411
51MAP3K61.02328638
52PRKD30.99748289
53CDK60.96825388
54EIF2AK10.95776795
55PDK20.95381022
56RIPK10.94582710
57PLK20.94065332
58DYRK1B0.93894780
59ILK0.93269481
60ICK0.92386900
61NEK90.91907913
62STK100.90580399
63STK380.90405583
64MAP3K120.90327994
65TGFBR20.88128640
66FGFR20.87670556
67BRSK20.86980267
68PAK40.86836090
69ROCK20.82239298
70PDGFRB0.79499546
71PRKG20.78301230
72TGFBR10.77994950
73PAK60.76795049
74KSR10.75712499
75MTOR0.75700963
76CDK120.74386283
77GRK70.73920311
78PIK3CG0.73269762
79EPHB10.72508977
80MST40.70841359
81MELK0.70279383
82FGFR30.68465893
83FRK0.68321730
84MAPKAPK50.65909293
85DMPK0.62885645
86NUAK10.60422078
87JAK10.59770231
88MAP2K10.59680549
89ERBB40.59409365
90MAPK70.55552172
91GSK3A0.54476308
92PRKD10.52719874
93PBK0.52538013
94INSR0.52089080
95PRKD20.49063235
96RPS6KA20.48909621
97PIK3CA0.48374336
98AURKB0.48225507
99SCYL20.47335507
100PTK2B0.46375718
101MAP3K130.44481165
102JAK30.44135181
103MAP3K20.40878987
104MKNK10.40396185
105RET0.40291207
106AKT30.40189936
107MAP3K80.38810366
108TAOK10.38676180
109WNK10.37486439
110MAP3K100.37190938
111MAPKAPK20.36974061
112KSR20.36749031
113SRC0.35563435
114ABL10.35546067
115CDK80.35437964
116MAP2K30.35420235
117PIM10.35222132
118ZAP700.34771682
119BMPR20.34183333
120IGF1R0.31050489
121PRKCH0.30875676
122ADRBK10.30104775
123ABL20.29291191
124RAF10.28663210
125PAK10.27660637
126TYRO30.27511578
127PRKCE0.24493777
128PDK40.24193110
129PDK30.24193110
130MAPK120.22951560
131MAPK10.22911918
132CDC42BPA0.22364458
133FGFR40.21528638
134PASK0.21272600

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.01029762
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.48152809
3Focal adhesion_Homo sapiens_hsa045103.05436683
4Protein digestion and absorption_Homo sapiens_hsa049742.70619529
5Proteoglycans in cancer_Homo sapiens_hsa052052.65154336
6Adherens junction_Homo sapiens_hsa045202.33637620
7TGF-beta signaling pathway_Homo sapiens_hsa043502.27206778
8Bladder cancer_Homo sapiens_hsa052192.21664564
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.12179474
10Hippo signaling pathway_Homo sapiens_hsa043902.11203560
11Amoebiasis_Homo sapiens_hsa051462.08315990
12MicroRNAs in cancer_Homo sapiens_hsa052062.03452905
13Small cell lung cancer_Homo sapiens_hsa052222.02101346
14p53 signaling pathway_Homo sapiens_hsa041151.91235892
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.84368315
16Basal cell carcinoma_Homo sapiens_hsa052171.79965282
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.76686747
18Malaria_Homo sapiens_hsa051441.74960666
19Other glycan degradation_Homo sapiens_hsa005111.72443521
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.65531809
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.63138488
22Sphingolipid metabolism_Homo sapiens_hsa006001.52525131
23Dilated cardiomyopathy_Homo sapiens_hsa054141.50510611
24Melanoma_Homo sapiens_hsa052181.36853717
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36405117
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34007528
27Chronic myeloid leukemia_Homo sapiens_hsa052201.31363721
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30214665
29Hedgehog signaling pathway_Homo sapiens_hsa043401.29933971
30Ribosome_Homo sapiens_hsa030101.28533864
31Tight junction_Homo sapiens_hsa045301.22906375
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.14702817
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12697568
34Axon guidance_Homo sapiens_hsa043601.12219934
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.09016742
36Glioma_Homo sapiens_hsa052141.06767855
37Viral myocarditis_Homo sapiens_hsa054161.03283323
38Rap1 signaling pathway_Homo sapiens_hsa040151.01619761
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01399360
40Wnt signaling pathway_Homo sapiens_hsa043101.01023621
41Pathways in cancer_Homo sapiens_hsa052000.96380991
42Melanogenesis_Homo sapiens_hsa049160.95977393
43Platelet activation_Homo sapiens_hsa046110.95070182
44Sulfur metabolism_Homo sapiens_hsa009200.94350637
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93938632
46Prostate cancer_Homo sapiens_hsa052150.93782900
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.93755522
48Prion diseases_Homo sapiens_hsa050200.93496089
49HTLV-I infection_Homo sapiens_hsa051660.91894390
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91669172
51Pancreatic cancer_Homo sapiens_hsa052120.89992749
52Shigellosis_Homo sapiens_hsa051310.88849419
53Phagosome_Homo sapiens_hsa041450.86735206
54Toxoplasmosis_Homo sapiens_hsa051450.85172492
55N-Glycan biosynthesis_Homo sapiens_hsa005100.83671696
56Renal cell carcinoma_Homo sapiens_hsa052110.82837392
57HIF-1 signaling pathway_Homo sapiens_hsa040660.82741734
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77805717
59VEGF signaling pathway_Homo sapiens_hsa043700.74791855
60Complement and coagulation cascades_Homo sapiens_hsa046100.74630598
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.74490156
62Thyroid cancer_Homo sapiens_hsa052160.72774911
63Vibrio cholerae infection_Homo sapiens_hsa051100.72377727
64Apoptosis_Homo sapiens_hsa042100.72348166
65Salmonella infection_Homo sapiens_hsa051320.71548318
66Ras signaling pathway_Homo sapiens_hsa040140.70021189
67Endometrial cancer_Homo sapiens_hsa052130.67907518
68Viral carcinogenesis_Homo sapiens_hsa052030.67291485
69Inositol phosphate metabolism_Homo sapiens_hsa005620.66606400
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.66038462
71TNF signaling pathway_Homo sapiens_hsa046680.65681701
72Arachidonic acid metabolism_Homo sapiens_hsa005900.65577938
73Colorectal cancer_Homo sapiens_hsa052100.65515051
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65509525
75Ovarian steroidogenesis_Homo sapiens_hsa049130.65281728
76African trypanosomiasis_Homo sapiens_hsa051430.64707786
77mTOR signaling pathway_Homo sapiens_hsa041500.61907233
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59881315
79Hepatitis C_Homo sapiens_hsa051600.58660083
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58407757
81Gap junction_Homo sapiens_hsa045400.56728458
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.56220719
83Influenza A_Homo sapiens_hsa051640.55025327
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54864014
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53958855
86Hepatitis B_Homo sapiens_hsa051610.52910903
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52850934
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52766870
89GnRH signaling pathway_Homo sapiens_hsa049120.52499149
90Renin-angiotensin system_Homo sapiens_hsa046140.50638890
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50317114
92Notch signaling pathway_Homo sapiens_hsa043300.49650472
93Estrogen signaling pathway_Homo sapiens_hsa049150.48690144
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48668182
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.48554961
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.47410630
97ErbB signaling pathway_Homo sapiens_hsa040120.45488328
98Galactose metabolism_Homo sapiens_hsa000520.44849807
99Acute myeloid leukemia_Homo sapiens_hsa052210.44260222
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.43734193
101Prolactin signaling pathway_Homo sapiens_hsa049170.43583698
102Endocytosis_Homo sapiens_hsa041440.42990621
103Rheumatoid arthritis_Homo sapiens_hsa053230.42675882
104Measles_Homo sapiens_hsa051620.41351647
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.41244914
106Cell cycle_Homo sapiens_hsa041100.41228784
107Pentose phosphate pathway_Homo sapiens_hsa000300.40773658
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39839104
109FoxO signaling pathway_Homo sapiens_hsa040680.37680780
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36023121
111Lysosome_Homo sapiens_hsa041420.34050260
112Thyroid hormone synthesis_Homo sapiens_hsa049180.34003883
113MAPK signaling pathway_Homo sapiens_hsa040100.33676765
114Osteoclast differentiation_Homo sapiens_hsa043800.32744370
115Oxytocin signaling pathway_Homo sapiens_hsa049210.32018252
116Legionellosis_Homo sapiens_hsa051340.30518686
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30358129
118Tuberculosis_Homo sapiens_hsa051520.29290729
119Dorso-ventral axis formation_Homo sapiens_hsa043200.29183409
120Steroid biosynthesis_Homo sapiens_hsa001000.28522090
121Pertussis_Homo sapiens_hsa051330.28458370
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27966908
123Non-small cell lung cancer_Homo sapiens_hsa052230.27640759
124Hematopoietic cell lineage_Homo sapiens_hsa046400.25437292

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