CD151

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)4.73837238
2plasma membrane repair (GO:0001778)4.27904753
3bundle of His cell to Purkinje myocyte communication (GO:0086069)4.21526057
4skin morphogenesis (GO:0043589)4.19698392
5Golgi transport vesicle coating (GO:0048200)4.10776663
6COPI coating of Golgi vesicle (GO:0048205)4.10776663
7fatty acid transmembrane transport (GO:1902001)4.03173260
8carnitine shuttle (GO:0006853)4.01792210
9type B pancreatic cell proliferation (GO:0044342)3.90403342
10regulation of sequestering of triglyceride (GO:0010889)3.88552503
11protein retention in ER lumen (GO:0006621)3.87977684
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87279886
13regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.85868931
14virion attachment to host cell (GO:0019062)3.85523121
15adhesion of symbiont to host cell (GO:0044650)3.85523121
16sarcomere organization (GO:0045214)3.84759829
17barbed-end actin filament capping (GO:0051016)3.84035607
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.69872747
19adhesion of symbiont to host (GO:0044406)3.69160720
20basement membrane organization (GO:0071711)3.65073077
21vascular endothelial growth factor signaling pathway (GO:0038084)3.62028155
22tricarboxylic acid cycle (GO:0006099)3.58180701
23protein localization to endosome (GO:0036010)3.52949617
24epithelial cell-cell adhesion (GO:0090136)3.52759811
25apoptotic cell clearance (GO:0043277)3.52187674
26fatty acid beta-oxidation (GO:0006635)3.39910578
27extracellular fibril organization (GO:0043206)3.37253778
28regulation of fatty acid oxidation (GO:0046320)3.36153237
29renal filtration (GO:0097205)3.35914071
30valine metabolic process (GO:0006573)3.33857877
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.28352505
32glomerular basement membrane development (GO:0032836)3.25568854
33semaphorin-plexin signaling pathway (GO:0071526)3.21451876
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.21146100
35positive regulation of fatty acid oxidation (GO:0046321)3.20738310
36retina vasculature morphogenesis in camera-type eye (GO:0061299)3.20030400
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.19027951
38regulation of tight junction assembly (GO:2000810)3.18629868
39carnitine transmembrane transport (GO:1902603)3.16645565
40negative regulation of smooth muscle cell migration (GO:0014912)3.14961151
41cell adhesion mediated by integrin (GO:0033627)3.14110149
422-oxoglutarate metabolic process (GO:0006103)3.13140515
43regulation of fatty acid beta-oxidation (GO:0031998)3.09800127
44sequestering of extracellular ligand from receptor (GO:0035581)3.09730162
45positive regulation of blood vessel endothelial cell migration (GO:0043536)3.09599245
46positive regulation of endothelial cell apoptotic process (GO:2000353)3.08169720
47vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.07888201
48negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.07661888
49regulation of cholesterol storage (GO:0010885)3.07484144
50lysine metabolic process (GO:0006553)3.06191835
51lysine catabolic process (GO:0006554)3.06191835
52tricarboxylic acid metabolic process (GO:0072350)3.06071213
53carnitine transport (GO:0015879)3.05880534
54amino-acid betaine transport (GO:0015838)3.05880534
55collagen metabolic process (GO:0032963)3.04249399
56regulation of early endosome to late endosome transport (GO:2000641)3.03865009
57focal adhesion assembly (GO:0048041)3.02881753
58cell-substrate adherens junction assembly (GO:0007045)3.02881753
59lipid particle organization (GO:0034389)3.01821497
60substrate-dependent cell migration (GO:0006929)3.01582666
61fibril organization (GO:0097435)3.01061485
62cardiac myofibril assembly (GO:0055003)2.99737325
63negative regulation of chondrocyte differentiation (GO:0032331)2.99511769
64endothelial cell chemotaxis (GO:0035767)2.99498504
65positive regulation of p38MAPK cascade (GO:1900745)2.98084997
66extracellular matrix disassembly (GO:0022617)2.96050142
67fatty acid oxidation (GO:0019395)2.95356902
68muscle filament sliding (GO:0030049)2.95175640
69actin-myosin filament sliding (GO:0033275)2.95175640
70* hemidesmosome assembly (GO:0031581)2.94948042
71extracellular matrix assembly (GO:0085029)2.94589361
72protein heterotrimerization (GO:0070208)2.94352257
73positive regulation of receptor recycling (GO:0001921)2.93395657
74chondrocyte proliferation (GO:0035988)2.92043541
75cell migration involved in heart development (GO:0060973)2.91289554
76* cell-substrate junction assembly (GO:0007044)2.89852604
77multicellular organismal macromolecule metabolic process (GO:0044259)2.89532914
78lipid oxidation (GO:0034440)2.89256963
79alpha-linolenic acid metabolic process (GO:0036109)2.88035445
80NADH metabolic process (GO:0006734)2.87940816
81regulation of skeletal muscle contraction (GO:0014819)2.86883737
82collagen catabolic process (GO:0030574)2.86318944
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84149279
84regulation of p38MAPK cascade (GO:1900744)2.83326078
85brown fat cell differentiation (GO:0050873)2.83178793
86positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83158210
87biotin metabolic process (GO:0006768)2.83089260
88regulation of extracellular matrix disassembly (GO:0010715)2.83067506
89glomerular filtration (GO:0003094)2.81748358
90positive regulation of osteoblast proliferation (GO:0033690)2.81004558
91fatty acid catabolic process (GO:0009062)2.80961528
92kidney mesenchyme development (GO:0072074)2.79981080
93cell migration involved in sprouting angiogenesis (GO:0002042)2.78417501
94negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78312063
95wound healing, spreading of epidermal cells (GO:0035313)2.76814352
964-hydroxyproline metabolic process (GO:0019471)2.75719027
97multicellular organismal metabolic process (GO:0044236)2.75619183
98cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.75255973
99stress fiber assembly (GO:0043149)2.72975031
100negative regulation of cell size (GO:0045792)2.72682408
101hyaluronan catabolic process (GO:0030214)2.72490164
102regulation of apoptotic process involved in morphogenesis (GO:1902337)2.71965454
103muscle cell migration (GO:0014812)2.71842233
104regulation of integrin-mediated signaling pathway (GO:2001044)2.70281510
105cellular response to vitamin D (GO:0071305)2.69749558
106multicellular organismal catabolic process (GO:0044243)2.69008018
107retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68954278
108mesodermal cell differentiation (GO:0048333)2.68325246
109intracellular lipid transport (GO:0032365)2.68189244
110heart trabecula formation (GO:0060347)2.67597771
111endothelial cell morphogenesis (GO:0001886)2.67298052
112triglyceride catabolic process (GO:0019433)2.67186607
113negative regulation of potassium ion transmembrane transport (GO:1901380)2.66886064
114atrioventricular valve morphogenesis (GO:0003181)2.66217835
115actin filament depolymerization (GO:0030042)2.66108717
116hypotonic response (GO:0006971)2.65695322
117fibroblast migration (GO:0010761)2.64952620
118bone trabecula formation (GO:0060346)2.63630958
119endodermal cell differentiation (GO:0035987)2.62660760
120endocardial cushion development (GO:0003197)2.60838794
121* extracellular matrix organization (GO:0030198)2.60536943
122actomyosin structure organization (GO:0031032)2.59962123
123regulation of plasminogen activation (GO:0010755)2.59447960
124* extracellular structure organization (GO:0043062)2.59355786
125oxaloacetate metabolic process (GO:0006107)2.58956764
126acetyl-CoA metabolic process (GO:0006084)2.57971850
127desmosome organization (GO:0002934)2.57244312
128heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.57215856
129actin-mediated cell contraction (GO:0070252)2.56999662
130cellular response to nutrient (GO:0031670)2.56634157
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.56093442
132ventricular cardiac muscle cell action potential (GO:0086005)2.55431306
133glial cell migration (GO:0008347)2.55364393
134white fat cell differentiation (GO:0050872)2.54919571
135wound healing, spreading of cells (GO:0044319)2.54420535
136adherens junction assembly (GO:0034333)2.53522206
137blood vessel endothelial cell migration (GO:0043534)2.53361058
138regulation of glomerular filtration (GO:0003093)2.52702120
139endocytic recycling (GO:0032456)2.52166174
140protein hydroxylation (GO:0018126)2.51707665
141protein maturation by protein folding (GO:0022417)2.51589546
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50928948
143substrate adhesion-dependent cell spreading (GO:0034446)2.50347376
144venous blood vessel morphogenesis (GO:0048845)2.50170343
145glomerular visceral epithelial cell development (GO:0072015)2.50107472
146cardiac muscle cell development (GO:0055013)2.49792648
147negative regulation of cartilage development (GO:0061037)2.49655073
148regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.49264268
149growth hormone receptor signaling pathway (GO:0060396)2.48912076
150myofibril assembly (GO:0030239)2.48350844
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48282877
152regulation of cardioblast differentiation (GO:0051890)2.47719223
153quaternary ammonium group transport (GO:0015697)2.47438937
154peptidyl-proline hydroxylation (GO:0019511)2.46996821
155protein carboxylation (GO:0018214)2.46788665
156peptidyl-glutamic acid carboxylation (GO:0017187)2.46788665
157collagen fibril organization (GO:0030199)2.46071065
158negative regulation of fatty acid transport (GO:2000192)2.45952440
159positive regulation of lipid storage (GO:0010884)2.43991737
160UV protection (GO:0009650)2.43672459
161branching involved in salivary gland morphogenesis (GO:0060445)2.43496808
162epoxygenase P450 pathway (GO:0019373)2.42439804
163actin filament bundle assembly (GO:0051017)2.42288486
164actin filament bundle organization (GO:0061572)2.42288486
165surfactant homeostasis (GO:0043129)2.41892326
166cellular response to growth hormone stimulus (GO:0071378)2.41588693
167regulation of glucose import in response to insulin stimulus (GO:2001273)2.40384665
168cardiac cell development (GO:0055006)2.39410814
169positive regulation of glycogen biosynthetic process (GO:0045725)2.39257660
170transcytosis (GO:0045056)2.38846819
171neutral lipid catabolic process (GO:0046461)2.38674228
172acylglycerol catabolic process (GO:0046464)2.38674228
173positive regulation of fatty acid metabolic process (GO:0045923)2.38558140
174cellular response to vitamin (GO:0071295)2.38409571
175branched-chain amino acid metabolic process (GO:0009081)2.37937615
176pentose-phosphate shunt (GO:0006098)2.37151611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.88245091
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.29210176
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.23527064
4CLOCK_20551151_ChIP-Seq_293T_Human3.77413759
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.54331525
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.50473329
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.46281596
8ZNF263_19887448_ChIP-Seq_K562_Human2.84545696
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.56534344
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55203838
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.52175199
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.40165110
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33533372
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.23428309
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.21102268
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.20929655
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05614518
18* ELK3_25401928_ChIP-Seq_HUVEC_Human1.92176458
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89242343
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.88792099
21TBX20_22080862_ChIP-Seq_HEART_Mouse1.86850631
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.86850631
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82128987
24* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82121414
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74806852
26RACK7_27058665_Chip-Seq_MCF-7_Human1.73380771
27* ATF3_27146783_Chip-Seq_COLON_Human1.72891655
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71287631
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.64381575
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63931172
31* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62591473
32* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61043343
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60703974
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57394312
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56789298
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.54332145
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.51596860
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48095710
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44500654
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.43358621
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.42488831
42LXR_22292898_ChIP-Seq_THP-1_Human1.41966591
43CJUN_26792858_Chip-Seq_BT549_Human1.40838444
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40727568
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40226941
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39207462
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38880582
48* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38242403
49* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37207073
50* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37207073
51* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.35884879
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35469117
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35147710
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33339829
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32851933
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29368796
57SMC3_22415368_ChIP-Seq_MEFs_Mouse1.28442446
58VDR_21846776_ChIP-Seq_THP-1_Human1.27181441
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26839437
60* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26580308
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26471849
62* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26294374
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26266794
64SOX2_20726797_ChIP-Seq_SW620_Human1.24777751
65* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23388655
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21458027
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21423998
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21199228
69* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20061711
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19591379
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18519380
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18159609
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18109227
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17911416
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.17894412
76* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17738078
77* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16964078
78* SA1_27219007_Chip-Seq_ERYTHROID_Human1.15603262
79* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15276356
80P68_20966046_ChIP-Seq_HELA_Human1.15044007
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13536857
82TET1_21490601_ChIP-Seq_MESCs_Mouse1.13386164
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13047563
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11238753
85CTCF_27219007_Chip-Seq_Bcells_Human1.10574885
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08539212
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08335319
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.07416861
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06881582
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06712411
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05930001
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05629685
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05309677
94* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04129440
95GATA4_25053715_ChIP-Seq_YYC3_Human1.03590599
96* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03521877
97TP53_22127205_ChIP-Seq_IMR90_Human1.03217180
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02232425
99SMC4_20622854_ChIP-Seq_HELA_Human1.01435415
100GATA6_25053715_ChIP-Seq_YYC3_Human1.00887913
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00061272
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99505477
103* TCF7_22412390_ChIP-Seq_EML_Mouse0.99221160
104GATA3_24758297_ChIP-Seq_MCF-7_Human0.99085005
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.97488745
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97402888
107* CREB1_26743006_Chip-Seq_LNCaP_Human0.97116135
108* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95811170
109* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95456964
110KDM2B_26808549_Chip-Seq_K562_Human0.95271283
111* KDM2B_26808549_Chip-Seq_DND41_Human0.94788617
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94739926
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.94615859
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94527410
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93919838
116SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92309930
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91951047
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91804930
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91797118
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91598333
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.90789949
122BRD4_25478319_ChIP-Seq_HGPS_Human0.89598974
123FOXA2_19822575_ChIP-Seq_HepG2_Human0.88760696
124TP63_22573176_ChIP-Seq_HFKS_Human0.88182791
125TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85546953
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84030518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.01572322
2MP0003705_abnormal_hypodermis_morpholog3.59085757
3MP0002837_dystrophic_cardiac_calcinosis3.20398671
4MP0004084_abnormal_cardiac_muscle3.19847671
5MP0004272_abnormal_basement_membrane2.92454243
6MP0005257_abnormal_intraocular_pressure2.90949614
7MP0005275_abnormal_skin_tensile2.80606835
8MP0005670_abnormal_white_adipose2.79933321
9MP0004130_abnormal_muscle_cell2.63044058
10MP0000751_myopathy2.62164954
11MP0005666_abnormal_adipose_tissue2.38657291
12MP0003566_abnormal_cell_adhesion2.33437211
13MP0000750_abnormal_muscle_regeneration2.15649368
14MP0004185_abnormal_adipocyte_glucose2.14148934
15MP0004036_abnormal_muscle_relaxation2.12490521
16MP0003279_aneurysm2.03216382
17MP0010030_abnormal_orbit_morphology2.00852894
18MP0005330_cardiomyopathy1.99038949
19MP0001958_emphysema1.97929674
20MP0000749_muscle_degeneration1.94824794
21MP0010368_abnormal_lymphatic_system1.92275480
22MP0004087_abnormal_muscle_fiber1.92062024
23MP0006138_congestive_heart_failure1.86156764
24MP0005375_adipose_tissue_phenotype1.77913934
25MP0008775_abnormal_heart_ventricle1.77525049
26MP0005623_abnormal_meninges_morphology1.72880305
27MP0003646_muscle_fatigue1.72043452
28MP0001542_abnormal_bone_strength1.70583718
29MP0004215_abnormal_myocardial_fiber1.69198976
30MP0002972_abnormal_cardiac_muscle1.60883351
31MP0001544_abnormal_cardiovascular_syste1.59776257
32MP0005385_cardiovascular_system_phenoty1.59776257
33MP0010630_abnormal_cardiac_muscle1.59319519
34MP0000013_abnormal_adipose_tissue1.54347889
35MP0005508_abnormal_skeleton_morphology1.49632898
36MP0002269_muscular_atrophy1.46874602
37MP0003828_pulmonary_edema1.45115108
38MP0003191_abnormal_cellular_cholesterol1.44062806
39MP0005620_abnormal_muscle_contractility1.43930188
40MP0001879_abnormal_lymphatic_vessel1.43295403
41MP0005409_darkened_coat_color1.39813116
42MP0009384_cardiac_valve_regurgitation1.38880755
43MP0010352_gastrointestinal_tract_polyps1.35298376
44MP0010234_abnormal_vibrissa_follicle1.32116087
45MP0005023_abnormal_wound_healing1.29889725
46MP0005595_abnormal_vascular_smooth1.28563891
47MP0000003_abnormal_adipose_tissue1.28469071
48MP0009780_abnormal_chondrocyte_physiolo1.28110782
49MP0000747_muscle_weakness1.28095978
50MP0009053_abnormal_anal_canal1.27800095
51MP0000343_altered_response_to1.26881961
52MP0000762_abnormal_tongue_morphology1.26778479
53MP0003453_abnormal_keratinocyte_physiol1.26546855
54MP0000759_abnormal_skeletal_muscle1.24984743
55MP0005503_abnormal_tendon_morphology1.23766452
56MP0010329_abnormal_lipoprotein_level1.23472264
57MP0003941_abnormal_skin_development1.22149361
58MP0000733_abnormal_muscle_development1.19210382
59MP0005360_urolithiasis1.16722123
60MP0003300_gastrointestinal_ulcer1.16680391
61MP0000467_abnormal_esophagus_morphology1.16205082
62MP0006054_spinal_hemorrhage1.15722736
63MP0004484_altered_response_of1.15283361
64MP0000858_altered_metastatic_potential1.15082150
65MP0005167_abnormal_blood-brain_barrier1.14368108
66MP0001348_abnormal_lacrimal_gland1.14333393
67MP0009840_abnormal_foam_cell1.13953631
68MP0002139_abnormal_hepatobiliary_system1.13112186
69MP0002060_abnormal_skin_morphology1.12167015
70MP0002106_abnormal_muscle_physiology1.11862865
71MP0004233_abnormal_muscle_weight1.11116514
72MP0001243_abnormal_dermal_layer1.10587502
73MP0003045_fibrosis1.09831311
74MP0002971_abnormal_brown_adipose1.06391171
75MP0002295_abnormal_pulmonary_circulatio1.03676955
76MP0001756_abnormal_urination1.02661116
77MP0004858_abnormal_nervous_system1.02097920
78MP0005451_abnormal_body_composition1.01701602
79MP0005501_abnormal_skin_physiology1.00770032
80MP0003950_abnormal_plasma_membrane0.99928161
81MP0005165_increased_susceptibility_to0.98959053
82MP0003221_abnormal_cardiomyocyte_apopto0.98014794
83MP0000767_abnormal_smooth_muscle0.96741390
84MP0005369_muscle_phenotype0.95238689
85MP0002796_impaired_skin_barrier0.94142489
86MP0005390_skeleton_phenotype0.93858440
87* MP0009643_abnormal_urine_homeostasis0.93568686
88MP0009115_abnormal_fat_cell0.93458995
89MP0003329_amyloid_beta_deposits0.93451120
90* MP0003091_abnormal_cell_migration0.91832270
91MP0002128_abnormal_blood_circulation0.91684409
92MP0001299_abnormal_eye_distance/0.91567088
93MP0002933_joint_inflammation0.90652430
94MP0005076_abnormal_cell_differentiation0.90611721
95MP0005332_abnormal_amino_acid0.90299142
96MP0005319_abnormal_enzyme/_coenzyme0.90095686
97MP0004510_myositis0.90006497
98MP0005083_abnormal_biliary_tract0.89956627
99MP0002118_abnormal_lipid_homeostasis0.89686311
100MP0002877_abnormal_melanocyte_morpholog0.89621016
101MP0005164_abnormal_response_to0.88684770
102MP0005365_abnormal_bile_salt0.87747719
103MP0003806_abnormal_nucleotide_metabolis0.86621512
104MP0002896_abnormal_bone_mineralization0.85383594
105MP0005197_abnormal_uvea_morphology0.83973182
106MP0000537_abnormal_urethra_morphology0.83651941
107MP0002168_other_aberrant_phenotype0.83289270
108MP0000678_abnormal_parathyroid_gland0.83201600
109MP0005058_abnormal_lysosome_morphology0.83178024
110MP0003186_abnormal_redox_activity0.82685503
111MP0000579_abnormal_nail_morphology0.82048218
112MP0002108_abnormal_muscle_morphology0.81798426
113MP0003567_abnormal_fetal_cardiomyocyte0.81785836
114MP0002998_abnormal_bone_remodeling0.80010385
115MP0001661_extended_life_span0.79702138
116MP0000266_abnormal_heart_morphology0.79333026
117MP0000163_abnormal_cartilage_morphology0.79024711
118MP0002089_abnormal_postnatal_growth/wei0.77814578
119MP0001216_abnormal_epidermal_layer0.77650597
120MP0001849_ear_inflammation0.76494018
121MP0000609_abnormal_liver_physiology0.76490947
122MP0010771_integument_phenotype0.75929276
123MP0003448_altered_tumor_morphology0.74975858
124* MP0001614_abnormal_blood_vessel0.74907386
125MP0003252_abnormal_bile_duct0.73919121
126MP0003942_abnormal_urinary_system0.73415421
127MP0005334_abnormal_fat_pad0.72915507
128MP0000462_abnormal_digestive_system0.71466879
129MP0002254_reproductive_system_inflammat0.70245502
130MP0003385_abnormal_body_wall0.70009558
131MP0002113_abnormal_skeleton_development0.69751033
132MP0000230_abnormal_systemic_arterial0.69464886
133MP0000534_abnormal_ureter_morphology0.69090872
134MP0000538_abnormal_urinary_bladder0.69053882
135MP0002970_abnormal_white_adipose0.68731447
136MP0009250_abnormal_appendicular_skeleto0.68723122
137MP0003137_abnormal_impulse_conducting0.68288851
138MP0005085_abnormal_gallbladder_physiolo0.67734634
139MP0008961_abnormal_basal_metabolism0.66724366
140MP0003283_abnormal_digestive_organ0.66504505
141MP0008260_abnormal_autophagy0.65989618
142MP0001533_abnormal_skeleton_physiology0.64690239
143* MP0000249_abnormal_blood_vessel0.64390791

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.62600157
2Increased connective tissue (HP:0009025)4.39061725
3Muscle fiber splitting (HP:0003555)4.07002702
4Hyporeflexia of lower limbs (HP:0002600)4.06781696
5Protrusio acetabuli (HP:0003179)3.93841229
6Premature rupture of membranes (HP:0001788)3.81721705
7Vertebral compression fractures (HP:0002953)3.68481032
8Ventricular tachycardia (HP:0004756)3.57241085
9Vascular tortuosity (HP:0004948)3.54716098
10Sudden death (HP:0001699)3.48931298
11Cerebral aneurysm (HP:0004944)3.47701992
12Arterial tortuosity (HP:0005116)3.34291446
13Ankle contracture (HP:0006466)3.28918496
14Difficulty running (HP:0009046)3.23443405
15Myoglobinuria (HP:0002913)3.19859432
16Wormian bones (HP:0002645)3.16909652
17Broad metatarsal (HP:0001783)3.12212673
18Difficulty climbing stairs (HP:0003551)3.12040629
19Aortic aneurysm (HP:0004942)3.06708816
20Exercise-induced muscle cramps (HP:0003710)2.98705872
21Lipoatrophy (HP:0100578)2.98275313
22Abnormality of dentin (HP:0010299)2.96069369
23Type 1 muscle fiber predominance (HP:0003803)2.92657407
24Spinal rigidity (HP:0003306)2.84690025
25Mesangial abnormality (HP:0001966)2.82137875
26Follicular hyperkeratosis (HP:0007502)2.76901521
27Aortic dissection (HP:0002647)2.75146637
28Increased variability in muscle fiber diameter (HP:0003557)2.74444534
29Asymmetric septal hypertrophy (HP:0001670)2.74279821
30Atrophic scars (HP:0001075)2.72588017
31Distal lower limb amyotrophy (HP:0008944)2.68092986
32Shallow orbits (HP:0000586)2.63024703
33Ulnar bowing (HP:0003031)2.62561172
34Aneurysm (HP:0002617)2.59436335
35Palpitations (HP:0001962)2.57425761
36Mitral regurgitation (HP:0001653)2.56568007
37Hyperacusis (HP:0010780)2.55135059
38Distal lower limb muscle weakness (HP:0009053)2.53323511
39Myotonia (HP:0002486)2.51923998
40Joint stiffness (HP:0001387)2.51758032
41Abnormality of skeletal muscle fiber size (HP:0012084)2.51046818
42Elbow flexion contracture (HP:0002987)2.46827450
43Acanthosis nigricans (HP:0000956)2.46775267
44Genu recurvatum (HP:0002816)2.46693850
45Rhabdomyolysis (HP:0003201)2.46537380
46EMG: myopathic abnormalities (HP:0003458)2.44577659
47Exercise-induced myalgia (HP:0003738)2.43568079
48Lymphangioma (HP:0100764)2.42585563
49Abnormality of the calf musculature (HP:0001430)2.40748516
50Thin bony cortex (HP:0002753)2.39729466
51Biconcave vertebral bodies (HP:0004586)2.38621649
52Broad face (HP:0000283)2.38244305
53Facial diplegia (HP:0001349)2.35875269
54Neonatal short-limb short stature (HP:0008921)2.35672351
55Scapular winging (HP:0003691)2.32060719
56Cervical subluxation (HP:0003308)2.30988957
57Abnormality of the Achilles tendon (HP:0005109)2.30774894
58Atrial fibrillation (HP:0005110)2.30660928
59Aortic regurgitation (HP:0001659)2.30611819
60Calf muscle hypertrophy (HP:0008981)2.27759819
61Upper limb amyotrophy (HP:0009129)2.26445527
62Distal upper limb amyotrophy (HP:0007149)2.26445527
63Mildly elevated creatine phosphokinase (HP:0008180)2.25905051
64Natal tooth (HP:0000695)2.24671597
65Hypoglycemic coma (HP:0001325)2.23939451
66Fragile skin (HP:0001030)2.22306089
67Coxa vara (HP:0002812)2.21919522
68Dilated cardiomyopathy (HP:0001644)2.21673582
69Polycythemia (HP:0001901)2.20204155
70Spondylolisthesis (HP:0003302)2.19876486
71Joint laxity (HP:0001388)2.17305842
72Mitral stenosis (HP:0001718)2.16259641
73Cardiovascular calcification (HP:0011915)2.16223816
74Abnormality of the acetabulum (HP:0003170)2.16012084
75Abnormality of fatty-acid metabolism (HP:0004359)2.15916756
76Primary atrial arrhythmia (HP:0001692)2.15755122
77Hyperextensible skin (HP:0000974)2.15710796
78Supraventricular arrhythmia (HP:0005115)2.15665882
79Hydroxyprolinuria (HP:0003080)2.15637858
80Abnormality of proline metabolism (HP:0010907)2.15637858
81Hyperglycinuria (HP:0003108)2.14740194
82Slender build (HP:0001533)2.13917066
83Peritonitis (HP:0002586)2.12048410
84Rectal prolapse (HP:0002035)2.11120223
85Disproportionate tall stature (HP:0001519)2.11054750
86Hypoalphalipoproteinemia (HP:0003233)2.10263158
87Wrist flexion contracture (HP:0001239)2.08468611
88Atrioventricular block (HP:0001678)2.08084668
89Muscle stiffness (HP:0003552)2.06154660
90Hand muscle atrophy (HP:0009130)2.05532970
91Bundle branch block (HP:0011710)2.05276157
92Supraventricular tachycardia (HP:0004755)2.04655656
93Limb-girdle muscle atrophy (HP:0003797)2.02341935
94Dysostosis multiplex (HP:0000943)2.00473331
95Abnormality of the distal phalanges of the toes (HP:0010182)1.99387363
96Bowel diverticulosis (HP:0005222)1.99143512
97Abnormal delivery (HP:0001787)1.98431494
98Back pain (HP:0003418)1.97999114
99Bowed forearm bones (HP:0003956)1.97723648
100Bowing of the arm (HP:0006488)1.97723648
101Osteolytic defects of the hand bones (HP:0009699)1.97433160
102Osteolytic defects of the phalanges of the hand (HP:0009771)1.97433160
103Multiple enchondromatosis (HP:0005701)1.97394553
104Long toe (HP:0010511)1.95792111
105Abnormal cartilage morphology (HP:0002763)1.95477796
106Mucopolysacchariduria (HP:0008155)1.94544905
107Urinary glycosaminoglycan excretion (HP:0003541)1.94544905
108Ketoacidosis (HP:0001993)1.94047865
109Abnormal atrioventricular conduction (HP:0005150)1.93625783
110Mitral valve prolapse (HP:0001634)1.92766106
111Aortic valve stenosis (HP:0001650)1.92164980
112Dilatation of the ascending aorta (HP:0005111)1.91828792
113Oligomenorrhea (HP:0000876)1.91624368
114Muscle hypertrophy of the lower extremities (HP:0008968)1.91556561
115Conjunctival hamartoma (HP:0100780)1.90572596
116Ventricular arrhythmia (HP:0004308)1.90224897
117Abnormality of polysaccharide metabolism (HP:0011012)1.88630902
118Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88630902
119Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88630902
120Xanthomatosis (HP:0000991)1.88215661
121Focal segmental glomerulosclerosis (HP:0000097)1.87775875
122Distal arthrogryposis (HP:0005684)1.86773479
123Enlarged penis (HP:0000040)1.84908863
124Stridor (HP:0010307)1.83736516
125Nuclear cataract (HP:0100018)1.82247644
126Knee flexion contracture (HP:0006380)1.82221443
127Hematochezia (HP:0002573)1.82105544
128Lower limb amyotrophy (HP:0007210)1.81467216
129Hyperammonemia (HP:0001987)1.80975584
130Ovoid vertebral bodies (HP:0003300)1.80870818
131Ectopia lentis (HP:0001083)1.80704450
132Deep venous thrombosis (HP:0002625)1.80496096
133Congenital glaucoma (HP:0001087)1.80003805
134Syncope (HP:0001279)1.79790035
135Abnormal ossification of hand bones (HP:0005921)1.79752849
136Reduced subcutaneous adipose tissue (HP:0003758)1.79094019
137Abnormality of carpal bone ossification (HP:0006257)1.78618031
138Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78543911
139Generalized amyotrophy (HP:0003700)1.78499366
140Hemorrhage of the eye (HP:0011885)1.78476549
141Testicular atrophy (HP:0000029)1.78164150
142Hypoventilation (HP:0002791)1.77856900
143Heart block (HP:0012722)1.77315923
144Flat acetabular roof (HP:0003180)1.76780749
145Myocardial infarction (HP:0001658)1.76679494
146Bladder diverticulum (HP:0000015)1.76249978
147Esophageal varix (HP:0002040)1.76160552
148Achilles tendon contracture (HP:0001771)1.75662143
149Short nail (HP:0001799)1.75033859
150Spinal cord compression (HP:0002176)1.74740984
151Soft skin (HP:0000977)1.74401034
152Hypertriglyceridemia (HP:0002155)1.73618507
153Axonal loss (HP:0003447)1.73240344
154Blue sclerae (HP:0000592)1.72683290
155Abnormality of glycine metabolism (HP:0010895)1.72675348
156Abnormality of serine family amino acid metabolism (HP:0010894)1.72675348
157J-shaped sella turcica (HP:0002680)1.72530397
158Ketosis (HP:0001946)1.72354547
159Round ear (HP:0100830)1.72028255
160Muscle fiber inclusion bodies (HP:0100299)1.72025837
161Vascular calcification (HP:0004934)1.70399841
162Nonimmune hydrops fetalis (HP:0001790)1.70163299
163Bradycardia (HP:0001662)1.69125830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.86437805
2TTN4.24547345
3PKN23.09528615
4LMTK22.64849117
5IRAK32.59662755
6ERN12.48562869
7BCKDK2.31108590
8TIE12.26496487
9MYLK2.24371526
10RIPK12.22948440
11PDK42.10307349
12PDK32.10307349
13SIK12.02259870
14EPHA22.01013039
15PDGFRA1.94999507
16MAPKAPK31.92238401
17LATS11.71869840
18EPHB21.71313640
19TGFBR21.67725081
20LRRK21.64243758
21FER1.58806749
22LATS21.55335189
23CAMK1D1.54023889
24DDR21.51834320
25ARAF1.51278833
26PTK61.49489540
27NEK11.48147058
28SMG11.46613390
29PDK21.46505397
30PAK41.35847820
31MAP3K31.35506075
32PRKD21.33369876
33MST1R1.33034851
34PHKG21.32499651
35PHKG11.32499651
36EEF2K1.30249160
37DMPK1.29332690
38KDR1.27551035
39MAP2K31.26065647
40PTK21.23878474
41CDC42BPA1.21473361
42FGFR41.16436063
43MAP3K61.15126325
44NEK91.14525381
45MET1.13020983
46NME21.11696074
47EPHB11.10949289
48TESK11.09850329
49ILK1.09345073
50MAP2K11.07540281
51PIK3CA1.06873678
52PAK21.05147910
53TGFBR11.03670018
54FLT30.99487171
55LIMK10.97568922
56STK38L0.95321062
57TAOK20.94425757
58TRPM70.94157633
59PAK30.93667948
60ERBB40.93237959
61RET0.93058976
62WNK40.92137314
63BMX0.91156989
64OBSCN0.90366455
65PRPF4B0.85332177
66CAMK1G0.84740086
67TESK20.80726965
68MTOR0.79679629
69FRK0.76712273
70PTK2B0.76536570
71ROCK10.76096303
72KSR20.75604110
73PRKD10.75557842
74PRKG20.75070673
75RPS6KB20.74903342
76MAP2K20.73396510
77MUSK0.71022881
78NTRK10.64512401
79MAP3K20.64194243
80PIK3CG0.61499749
81CDK60.60973142
82ZAP700.60338495
83EPHA30.59929575
84PIM20.59127853
85PRKAA20.58419953
86PRKD30.58074009
87SCYL20.57682617
88PDGFRB0.57550683
89FGFR10.56114282
90DAPK30.55049339
91MAP3K130.52567971
92MAP3K110.52070050
93BRAF0.50139438
94MAP3K70.49959523
95RPS6KC10.49588311
96RPS6KL10.49588311
97STK100.49456929
98CAMK2G0.49208664
99FGFR30.48785858
100STK30.47931148
101CDK80.46521900
102PAK10.45952103
103ADRBK10.45676561
104RPS6KA60.43818481
105GSK3A0.42363624
106ICK0.41531359
107MAP3K80.41374963
108PRKAA10.38768952
109MARK20.38474557
110PDPK10.38284483
111DYRK1B0.36961124
112MAPKAPK20.36953794
113STK380.36462449
114ROCK20.35461502
115MAP3K100.35368075
116TAOK10.34231524
117MAP3K10.34002161
118ABL20.32991424
119MOS0.31722271
120TBK10.31215240
121MATK0.31038972
122SRC0.30642166
123MAPK120.30520849
124RPS6KA20.29073193
125MAPK150.27719372
126PRKCI0.27274379
127CAMK2D0.26912157
128MAPK110.26883003
129AKT20.22713870
130HIPK20.21927748
131CAMK2B0.21721230

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.91562464
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.25600747
3Fatty acid degradation_Homo sapiens_hsa000712.90641584
4Propanoate metabolism_Homo sapiens_hsa006402.83992675
5Other glycan degradation_Homo sapiens_hsa005112.67117233
6Fatty acid metabolism_Homo sapiens_hsa012122.51009242
7PPAR signaling pathway_Homo sapiens_hsa033202.49104355
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46802059
9ECM-receptor interaction_Homo sapiens_hsa045122.17215153
10Carbon metabolism_Homo sapiens_hsa012002.03129333
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89066555
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86955319
13Pyruvate metabolism_Homo sapiens_hsa006201.86892056
14Dilated cardiomyopathy_Homo sapiens_hsa054141.80873938
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.74430739
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73482494
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73120433
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71944733
19Focal adhesion_Homo sapiens_hsa045101.71331532
20Fatty acid biosynthesis_Homo sapiens_hsa000611.70153096
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.46516784
22Prion diseases_Homo sapiens_hsa050201.34620635
23Fat digestion and absorption_Homo sapiens_hsa049751.34192970
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32539999
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.30417073
26Caffeine metabolism_Homo sapiens_hsa002321.30211503
27Nitrogen metabolism_Homo sapiens_hsa009101.28194540
28Adherens junction_Homo sapiens_hsa045201.26658141
29Arginine biosynthesis_Homo sapiens_hsa002201.26345203
30Tryptophan metabolism_Homo sapiens_hsa003801.26334605
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25775350
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21152129
33Small cell lung cancer_Homo sapiens_hsa052221.19454783
34Insulin resistance_Homo sapiens_hsa049311.17133894
35Amoebiasis_Homo sapiens_hsa051461.17053100
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16968778
37Proteoglycans in cancer_Homo sapiens_hsa052051.16481658
38Notch signaling pathway_Homo sapiens_hsa043301.16264878
39Glycerolipid metabolism_Homo sapiens_hsa005611.15089070
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13083497
41Protein digestion and absorption_Homo sapiens_hsa049741.12172607
42AMPK signaling pathway_Homo sapiens_hsa041521.10001730
43Bladder cancer_Homo sapiens_hsa052191.09220714
44beta-Alanine metabolism_Homo sapiens_hsa004101.08452445
45Biosynthesis of amino acids_Homo sapiens_hsa012301.05305463
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04048131
47Starch and sucrose metabolism_Homo sapiens_hsa005001.03873614
48Viral myocarditis_Homo sapiens_hsa054161.03619813
49N-Glycan biosynthesis_Homo sapiens_hsa005100.99991410
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99917671
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99367726
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.98863725
53Vibrio cholerae infection_Homo sapiens_hsa051100.97650573
54Insulin signaling pathway_Homo sapiens_hsa049100.96017337
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95315407
56Tight junction_Homo sapiens_hsa045300.95266038
57Butanoate metabolism_Homo sapiens_hsa006500.95219029
58Peroxisome_Homo sapiens_hsa041460.92521719
59Bile secretion_Homo sapiens_hsa049760.89575103
60Cardiac muscle contraction_Homo sapiens_hsa042600.89535293
61Complement and coagulation cascades_Homo sapiens_hsa046100.87126006
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87082403
63Axon guidance_Homo sapiens_hsa043600.85989103
64Sphingolipid metabolism_Homo sapiens_hsa006000.80964304
65Phenylalanine metabolism_Homo sapiens_hsa003600.78210619
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.76832330
67HIF-1 signaling pathway_Homo sapiens_hsa040660.76809681
68Tyrosine metabolism_Homo sapiens_hsa003500.76020745
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75399600
70Malaria_Homo sapiens_hsa051440.73276188
71Shigellosis_Homo sapiens_hsa051310.73259769
72Endocytosis_Homo sapiens_hsa041440.72497159
73Thyroid cancer_Homo sapiens_hsa052160.71888131
74Pentose phosphate pathway_Homo sapiens_hsa000300.71152477
75TNF signaling pathway_Homo sapiens_hsa046680.70530804
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68226211
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.68127882
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.67899666
79Hippo signaling pathway_Homo sapiens_hsa043900.66950143
80MicroRNAs in cancer_Homo sapiens_hsa052060.66282929
81Lysine degradation_Homo sapiens_hsa003100.66116026
82Fructose and mannose metabolism_Homo sapiens_hsa000510.65857711
83Glucagon signaling pathway_Homo sapiens_hsa049220.65841923
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65372322
85Galactose metabolism_Homo sapiens_hsa000520.64903034
86Salmonella infection_Homo sapiens_hsa051320.62809009
87Glutathione metabolism_Homo sapiens_hsa004800.62756190
88Basal cell carcinoma_Homo sapiens_hsa052170.62525992
89Pertussis_Homo sapiens_hsa051330.62113170
90Fatty acid elongation_Homo sapiens_hsa000620.61188092
91Renal cell carcinoma_Homo sapiens_hsa052110.61164815
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59450361
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58076422
94GnRH signaling pathway_Homo sapiens_hsa049120.58029385
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.56466220
96Toxoplasmosis_Homo sapiens_hsa051450.56176814
97Chronic myeloid leukemia_Homo sapiens_hsa052200.54844089
98Estrogen signaling pathway_Homo sapiens_hsa049150.54716410
99Gap junction_Homo sapiens_hsa045400.54655342
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54536091
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54285526
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.54273096
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.54259041
104Glioma_Homo sapiens_hsa052140.54213620
105Lysosome_Homo sapiens_hsa041420.53891253
106Arginine and proline metabolism_Homo sapiens_hsa003300.53376520
107TGF-beta signaling pathway_Homo sapiens_hsa043500.52729834
108Melanogenesis_Homo sapiens_hsa049160.52602821
109Sulfur metabolism_Homo sapiens_hsa009200.52551764
110Apoptosis_Homo sapiens_hsa042100.50627968
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50127321
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49975951
113mTOR signaling pathway_Homo sapiens_hsa041500.49194244
114Acute myeloid leukemia_Homo sapiens_hsa052210.48842257
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48763576
116Renin-angiotensin system_Homo sapiens_hsa046140.48401041
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48057573
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47835501
119Chemical carcinogenesis_Homo sapiens_hsa052040.45535223
120VEGF signaling pathway_Homo sapiens_hsa043700.45437532
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43401226
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43241015
123Melanoma_Homo sapiens_hsa052180.42655015
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42599902
125Hepatitis C_Homo sapiens_hsa051600.42306171
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38552881
127Platelet activation_Homo sapiens_hsa046110.36305945
128Thyroid hormone synthesis_Homo sapiens_hsa049180.34585330
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34505469
130Sulfur relay system_Homo sapiens_hsa041220.33318456
131Pathways in cancer_Homo sapiens_hsa052000.32737857
132Mineral absorption_Homo sapiens_hsa049780.32621944
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32506690
134Selenocompound metabolism_Homo sapiens_hsa004500.32304540
135Rap1 signaling pathway_Homo sapiens_hsa040150.32184696
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31889416
137Pancreatic cancer_Homo sapiens_hsa052120.30529381
138Endometrial cancer_Homo sapiens_hsa052130.30416863

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