CD163L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)8.78653995
2positive thymic T cell selection (GO:0045059)7.96292244
3regulation of gamma-delta T cell differentiation (GO:0045586)7.94503743
4positive T cell selection (GO:0043368)7.63276558
5interferon-gamma production (GO:0032609)7.44710746
6negative T cell selection (GO:0043383)7.13213813
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.02797720
8regulation of gamma-delta T cell activation (GO:0046643)6.95306438
9negative thymic T cell selection (GO:0045060)6.83067788
10T cell migration (GO:0072678)6.55806842
11thymic T cell selection (GO:0045061)6.55092356
12response to interleukin-15 (GO:0070672)6.16273414
13leukocyte aggregation (GO:0070486)6.03915861
14T cell selection (GO:0045058)5.78157213
15T cell receptor signaling pathway (GO:0050852)5.64374913
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.43737239
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.43737239
18glycosphingolipid catabolic process (GO:0046479)5.16955295
19cellular response to interleukin-15 (GO:0071350)5.10566248
20regulation of isotype switching to IgG isotypes (GO:0048302)5.04111619
21regulation of mononuclear cell migration (GO:0071675)4.92915825
22activated T cell proliferation (GO:0050798)4.88127269
23virion attachment to host cell (GO:0019062)4.70607880
24adhesion of symbiont to host cell (GO:0044650)4.70607880
25glycolipid catabolic process (GO:0019377)4.67643067
26regulation of cytokine secretion involved in immune response (GO:0002739)4.66818258
27antigen receptor-mediated signaling pathway (GO:0050851)4.60267955
28oligosaccharide catabolic process (GO:0009313)4.57287916
29negative regulation of interleukin-12 production (GO:0032695)4.48296462
30antigen processing and presentation of endogenous antigen (GO:0019883)4.43353859
31T cell costimulation (GO:0031295)4.39956510
32lymphocyte costimulation (GO:0031294)4.32396019
33regulation of B cell receptor signaling pathway (GO:0050855)4.29930160
34regulation of vitamin D biosynthetic process (GO:0060556)4.24323090
35positive regulation of chemokine biosynthetic process (GO:0045080)4.19090767
36adhesion of symbiont to host (GO:0044406)4.10683632
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.09258069
38ceramide catabolic process (GO:0046514)4.07006560
39regulation of vitamin metabolic process (GO:0030656)4.05046150
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.00668339
41amino sugar catabolic process (GO:0046348)3.99907317
42regulation of regulatory T cell differentiation (GO:0045589)3.97402519
43regulation of T cell receptor signaling pathway (GO:0050856)3.93358489
44macrophage activation involved in immune response (GO:0002281)3.93356732
45response to peptidoglycan (GO:0032494)3.92259155
46heterotypic cell-cell adhesion (GO:0034113)3.91491489
47leukocyte cell-cell adhesion (GO:0007159)3.91385804
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.91083715
49mast cell degranulation (GO:0043303)3.85121604
50mast cell activation involved in immune response (GO:0002279)3.85121604
51neutrophil activation involved in immune response (GO:0002283)3.83511073
52angiotensin maturation (GO:0002003)3.82964177
53positive regulation of isotype switching (GO:0045830)3.76518050
54natural killer cell differentiation (GO:0001779)3.73921243
55T-helper 1 type immune response (GO:0042088)3.73169215
56response to acidic pH (GO:0010447)3.73145373
57regulation of podosome assembly (GO:0071801)3.70233688
58T cell differentiation (GO:0030217)3.69582002
59negative regulation of nitric oxide biosynthetic process (GO:0045019)3.69422439
60membrane lipid catabolic process (GO:0046466)3.69207175
61positive regulation of histone deacetylation (GO:0031065)3.66532399
62mast cell activation (GO:0045576)3.66071566
63positive regulation of interleukin-2 production (GO:0032743)3.63631028
64negative regulation of erythrocyte differentiation (GO:0045647)3.62257030
65lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62207946
66sphingolipid catabolic process (GO:0030149)3.60029697
67immunoglobulin mediated immune response (GO:0016064)3.59826443
68regulation of T cell tolerance induction (GO:0002664)3.56377457
69cellular response to thyroid hormone stimulus (GO:0097067)3.55159558
70viral transcription (GO:0019083)3.53627819
71regulation of chemokine biosynthetic process (GO:0045073)3.52209953
72positive regulation of heat generation (GO:0031652)3.50353693
73megakaryocyte development (GO:0035855)3.49792919
74alpha-beta T cell activation (GO:0046631)3.49495648
75regulation of B cell differentiation (GO:0045577)3.49372954
76NIK/NF-kappaB signaling (GO:0038061)3.46663513
77V(D)J recombination (GO:0033151)3.43610116
78eosinophil chemotaxis (GO:0048245)3.39729209
79ribosomal small subunit assembly (GO:0000028)3.37906453
80lymphocyte migration (GO:0072676)3.37331812
81cellular response to interleukin-4 (GO:0071353)3.36732121
82immune response-activating cell surface receptor signaling pathway (GO:0002429)3.34075673
83positive regulation of Rap GTPase activity (GO:0032854)3.33432932
84positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.33109054
85regulation of membrane protein ectodomain proteolysis (GO:0051043)3.32089768
86regulation of fever generation (GO:0031620)3.31204339
87cell wall macromolecule catabolic process (GO:0016998)3.31153454
88N-acetylneuraminate metabolic process (GO:0006054)3.28503133
89translational termination (GO:0006415)3.27880903
90negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.27848350
91Arp2/3 complex-mediated actin nucleation (GO:0034314)3.27713076
92regulation of interferon-beta biosynthetic process (GO:0045357)3.24627074
93T cell activation (GO:0042110)3.22827893
94signal complex assembly (GO:0007172)3.21106548
95regulation of macrophage chemotaxis (GO:0010758)3.20631807
96positive regulation of monocyte chemotaxis (GO:0090026)3.20102820
97Peyers patch development (GO:0048541)3.18801039
98mucosal-associated lymphoid tissue development (GO:0048537)3.18801039
99regulation of natural killer cell mediated immunity (GO:0002715)3.17693889
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.17693889
101sequestering of actin monomers (GO:0042989)3.17626997
102T cell homeostasis (GO:0043029)3.17335473
103regulation of isotype switching (GO:0045191)3.17059301
104monocyte chemotaxis (GO:0002548)3.16924759
105peptide catabolic process (GO:0043171)3.16203441
106barbed-end actin filament capping (GO:0051016)3.16161826
107leukocyte tethering or rolling (GO:0050901)3.15815544
108alpha-beta T cell differentiation (GO:0046632)3.15803374
109regulation of interferon-alpha production (GO:0032647)3.14878871
110response to interleukin-4 (GO:0070670)3.14560943
111low-density lipoprotein particle clearance (GO:0034383)3.12235224
112regulation of chronic inflammatory response (GO:0002676)3.11538397
113negative regulation of T cell mediated immunity (GO:0002710)3.11293341
114B cell receptor signaling pathway (GO:0050853)3.11132417
115positive regulation of leukocyte degranulation (GO:0043302)3.10428075
116myeloid dendritic cell differentiation (GO:0043011)3.10268436
117negative regulation of lymphocyte mediated immunity (GO:0002707)3.10208943
118natural killer cell activation (GO:0030101)3.08931677
119fat-soluble vitamin biosynthetic process (GO:0042362)3.08298973
120cellular response to arsenic-containing substance (GO:0071243)3.05801673
121platelet formation (GO:0030220)3.03577280
122response to thyroid hormone (GO:0097066)3.01609967
123positive regulation of DNA recombination (GO:0045911)3.00816853
124adaptation of signaling pathway (GO:0023058)3.00332270
125negative regulation of T cell receptor signaling pathway (GO:0050860)2.99785961
126T cell proliferation (GO:0042098)2.99737320
127eosinophil migration (GO:0072677)2.99094647
128interferon-gamma-mediated signaling pathway (GO:0060333)2.98636008
129branching involved in labyrinthine layer morphogenesis (GO:0060670)2.98427461
130regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.97267613
131negative regulation of cytokine production involved in immune response (GO:0002719)2.96860415
132positive regulation of T cell differentiation (GO:0045582)2.95447484
133regulation of response to interferon-gamma (GO:0060330)2.93937476
134fusion of sperm to egg plasma membrane (GO:0007342)2.91285545
135positive regulation of lamellipodium assembly (GO:0010592)2.91245020
136regulation of mast cell degranulation (GO:0043304)2.89861075
137mature B cell differentiation involved in immune response (GO:0002313)2.88441900
138negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.87235542
139alternative mRNA splicing, via spliceosome (GO:0000380)2.87073234
140positive regulation of mRNA catabolic process (GO:0061014)2.85711781
141cellular extravasation (GO:0045123)2.84421901
142regulation of alpha-beta T cell proliferation (GO:0046640)2.84218868
143regulation of cholesterol storage (GO:0010885)2.83960482
144positive regulation of T cell activation (GO:0050870)2.82223612
145negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.82204071
146positive regulation by symbiont of host defense response (GO:0052509)2.82202138
147modulation by symbiont of host defense response (GO:0052031)2.82202138
148modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82202138
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82202138
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.82202138
151modulation by symbiont of host immune response (GO:0052553)2.82202138
152positive regulation of B cell mediated immunity (GO:0002714)2.82127221
153positive regulation of immunoglobulin mediated immune response (GO:0002891)2.82127221
154negative regulation of leukocyte mediated immunity (GO:0002704)2.80835618
155JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.80355588
156negative regulation of phagocytosis (GO:0050765)2.80244686
157nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80014596
158positive regulation of mast cell activation involved in immune response (GO:0033008)2.79958106
159positive regulation of mast cell degranulation (GO:0043306)2.79958106
160protein localization to endosome (GO:0036010)2.79909350
161DNA unwinding involved in DNA replication (GO:0006268)2.79473444
162positive regulation of protein deacetylation (GO:0090312)2.79070050
163translational elongation (GO:0006414)2.78983653
164regulation of Rap GTPase activity (GO:0032317)2.77378459
165positive regulation of tolerance induction (GO:0002645)2.76952279
166macrophage differentiation (GO:0030225)2.76183796
167regulation of leukocyte mediated cytotoxicity (GO:0001910)2.75938489
168lymphocyte homeostasis (GO:0002260)2.75676100
169positive regulation of humoral immune response (GO:0002922)2.75165950
170cell wall macromolecule metabolic process (GO:0044036)2.75091876
171sexual reproduction (GO:0019953)2.74561364
172regulation of superoxide anion generation (GO:0032928)2.71492256
173cellular response to lipopolysaccharide (GO:0071222)2.70578753
174regulation of T-helper 1 cell differentiation (GO:0045625)2.70282851
175regulation of T-helper 2 cell differentiation (GO:0045628)2.70221862
176granulocyte activation (GO:0036230)2.69353159
177regulation of monocyte chemotaxis (GO:0090025)2.69241359
178regulation of interleukin-8 biosynthetic process (GO:0045414)2.69076539
179hyaluronan catabolic process (GO:0030214)2.68783716
180pinocytosis (GO:0006907)2.68745926
181adenosine receptor signaling pathway (GO:0001973)2.68070756
182regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.67590363
183positive regulation of interleukin-6 production (GO:0032755)2.67123325
184cellular response to type I interferon (GO:0071357)2.67017514
185type I interferon signaling pathway (GO:0060337)2.67017514
186regulation of nitric oxide biosynthetic process (GO:0045428)2.66006280
187regulation of mast cell activation involved in immune response (GO:0033006)2.65997332
188negative regulation of myeloid cell apoptotic process (GO:0033033)2.63366243
189positive regulation of interferon-alpha production (GO:0032727)2.62564834
190germinal center formation (GO:0002467)2.62538047
191response to type I interferon (GO:0034340)2.61873798
192dendritic cell differentiation (GO:0097028)2.61724815
193myeloid dendritic cell activation (GO:0001773)2.61546602
194positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61365185
195regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.60821152
196cyclooxygenase pathway (GO:0019371)2.60692508
197cellular response to molecule of bacterial origin (GO:0071219)2.59061988
198regulation of leukocyte degranulation (GO:0043300)2.56092402
199negative regulation of cell killing (GO:0031342)10.0040581
200negative regulation of leukocyte mediated cytotoxicity (GO:0001911)10.0040581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.37960652
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.28498908
3E2F7_22180533_ChIP-Seq_HELA_Human5.26383130
4MYC_22102868_ChIP-Seq_BL_Human4.83293298
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.33009224
6* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.45538967
7RUNX_20019798_ChIP-Seq_JUKART_Human3.38827179
8VDR_21846776_ChIP-Seq_THP-1_Human3.36752849
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.31443112
10UTX_26944678_Chip-Seq_JUKART_Human3.25415972
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.18499401
12MYB_26560356_Chip-Seq_TH2_Human3.15072301
13MAF_26560356_Chip-Seq_TH1_Human3.07925061
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.00587154
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92229374
16TCF7_22412390_ChIP-Seq_EML_Mouse2.90604640
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86020132
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.82196104
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81700934
20KDM2B_26808549_Chip-Seq_DND41_Human2.65821271
21MYB_26560356_Chip-Seq_TH1_Human2.65432674
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61571059
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.61266985
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.55927981
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47176150
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.43740861
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24494186
28SCL_19346495_ChIP-Seq_HPC-7_Human2.22284777
29VDR_24763502_ChIP-Seq_THP-1_Human2.20596549
30MAF_26560356_Chip-Seq_TH2_Human2.15262797
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13452726
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12791039
33RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12283209
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.07925029
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04145821
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02001171
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00524626
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98861810
39VDR_24787735_ChIP-Seq_THP-1_Human1.95127003
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92993596
41GATA3_27048872_Chip-Seq_THYMUS_Human1.89322018
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.87611009
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.81816751
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80308550
45CIITA_25753668_ChIP-Seq_RAJI_Human1.76176098
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75460613
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74735735
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.71700318
49SPI1_23127762_ChIP-Seq_K562_Human1.65799848
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64026091
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61312655
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60808102
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.53910169
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52159622
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51615480
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51343990
57SPI1_23547873_ChIP-Seq_NB4_Human1.51041192
58LXR_22292898_ChIP-Seq_THP-1_Human1.49824298
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.48704533
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48599442
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48338027
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48068424
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47485892
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46813560
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45516877
66* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44759140
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43230391
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43082961
69BCOR_27268052_Chip-Seq_Bcells_Human1.41609909
70* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41467550
71BCL6_27268052_Chip-Seq_Bcells_Human1.41301658
72STAT1_20625510_ChIP-Seq_HELA_Human1.39406998
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37478880
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36071423
75TFEB_21752829_ChIP-Seq_HELA_Human1.35441207
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30894307
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.30005920
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28993550
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28942631
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.28493203
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27777445
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26044079
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.25473841
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23574940
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22005651
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21495554
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19536288
88NCOR1_26117541_ChIP-Seq_K562_Human1.18863248
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18385232
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.17244986
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16663808
92* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16286908
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15283706
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12853593
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12484266
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12112619
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10391412
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10297365
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.09899471
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07211975
101GATA1_19941826_ChIP-Seq_K562_Human1.07066756
102RACK7_27058665_Chip-Seq_MCF-7_Human1.06141599
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05933711
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05756681
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05644937
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.04120511
107* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03769886
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03228957
109LXR_22158963_ChIP-Seq_LIVER_Mouse1.03100225
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02964014
111IRF8_27001747_Chip-Seq_BMDM_Mouse1.01646874
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00968149
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99654024
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99475144
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.98739028
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98382991
117ATF3_27146783_Chip-Seq_COLON_Human0.98318481
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97693365
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96592628
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96592628
121GATA2_19941826_ChIP-Seq_K562_Human0.96374899
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96296576
123STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95894905
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95766992
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95492149
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94956600
127CTCF_21964334_Chip-Seq_Bcells_Human0.94724882
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94673429
129* SOX2_20726797_ChIP-Seq_SW620_Human0.93073916
130CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92957797
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91091605
132LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91017371
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90576036
134CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89853065
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89682976
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89590270
137CJUN_26792858_Chip-Seq_BT549_Human0.89013857
138PU_27001747_Chip-Seq_BMDM_Mouse0.88926405
139P68_20966046_ChIP-Seq_HELA_Human0.88656843
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87677600
141GATA3_26560356_Chip-Seq_TH2_Human0.87503381
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.87037296
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86898446
144SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.86617113
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85174015
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84888937
147ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84600322
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83300524
149MYC_19079543_ChIP-ChIP_MESCs_Mouse0.83281768
150EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83134770
151CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83025218
152WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82258678
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81400472
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80130447
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79244348
156CLOCK_20551151_ChIP-Seq_293T_Human0.79169702
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78990744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.76744149
2MP0005058_abnormal_lysosome_morphology4.97090485
3MP0000685_abnormal_immune_system3.43487361
4MP0005671_abnormal_response_to3.43372336
5MP0002396_abnormal_hematopoietic_system3.34858737
6MP0002139_abnormal_hepatobiliary_system3.26902305
7MP0000703_abnormal_thymus_morphology3.13650808
8MP0002398_abnormal_bone_marrow3.01208674
9MP0001800_abnormal_humoral_immune2.91458945
10MP0001873_stomach_inflammation2.81295317
11MP0009278_abnormal_bone_marrow2.75729604
12MP0002420_abnormal_adaptive_immunity2.74085781
13MP0001819_abnormal_immune_cell2.70285115
14MP0003300_gastrointestinal_ulcer2.63979370
15MP0002723_abnormal_immune_serum2.55172914
16MP0005451_abnormal_body_composition2.54082513
17MP0002722_abnormal_immune_system2.53944180
18MP0000343_altered_response_to2.51685368
19MP0000716_abnormal_immune_system2.49906920
20MP0003806_abnormal_nucleotide_metabolis2.40841324
21MP0005464_abnormal_platelet_physiology2.40817212
22MP0003866_abnormal_defecation2.37555182
23MP0002452_abnormal_antigen_presenting2.28593354
24MP0005410_abnormal_fertilization2.28289735
25MP0001790_abnormal_immune_system2.25188929
26MP0005387_immune_system_phenotype2.25188929
27MP0009333_abnormal_splenocyte_physiolog2.25092690
28MP0002405_respiratory_system_inflammati2.24720532
29MP0003172_abnormal_lysosome_physiology2.23701012
30MP0003075_altered_response_to2.22272076
31MP0005397_hematopoietic_system_phenotyp2.18466048
32MP0001545_abnormal_hematopoietic_system2.18466048
33MP0000689_abnormal_spleen_morphology2.17242474
34MP0009764_decreased_sensitivity_to2.14199014
35MP0004808_abnormal_hematopoietic_stem2.12032378
36MP0005000_abnormal_immune_tolerance2.11375782
37MP0008961_abnormal_basal_metabolism2.09928837
38MP0002166_altered_tumor_susceptibility2.05035967
39MP0003303_peritoneal_inflammation2.03473356
40MP0002429_abnormal_blood_cell2.02975899
41MP0010352_gastrointestinal_tract_polyps2.00210703
42MP0010155_abnormal_intestine_physiology1.96413961
43MP0005025_abnormal_response_to1.94826408
44MP0004947_skin_inflammation1.90365909
45MP0001835_abnormal_antigen_presentation1.84369029
46MP0003436_decreased_susceptibility_to1.76087534
47MP0002006_tumorigenesis1.75965860
48MP0002419_abnormal_innate_immunity1.71775257
49MP0005167_abnormal_blood-brain_barrier1.64137952
50MP0008004_abnormal_stomach_pH1.63693751
51MP0002933_joint_inflammation1.61332022
52MP0000858_altered_metastatic_potential1.61039471
53MP0003724_increased_susceptibility_to1.60308087
54MP0005166_decreased_susceptibility_to1.58561949
55MP0002998_abnormal_bone_remodeling1.57150233
56MP0004185_abnormal_adipocyte_glucose1.53332428
57MP0000465_gastrointestinal_hemorrhage1.52370707
58MP0001845_abnormal_inflammatory_respons1.49934208
59MP0006054_spinal_hemorrhage1.49147555
60MP0005365_abnormal_bile_salt1.46278166
61MP0005023_abnormal_wound_healing1.45238998
62MP0004510_myositis1.38669940
63MP0008260_abnormal_autophagy1.28571673
64MP0003183_abnormal_peptide_metabolism1.28401063
65MP0004381_abnormal_hair_follicle1.28270511
66MP0001542_abnormal_bone_strength1.27824949
67MP0005165_increased_susceptibility_to1.25454184
68MP0005076_abnormal_cell_differentiation1.21670628
69MP0005174_abnormal_tail_pigmentation1.21198180
70MP0009785_altered_susceptibility_to1.16593877
71MP0003690_abnormal_glial_cell1.15712406
72MP0002138_abnormal_hepatobiliary_system1.15431706
73MP0000490_abnormal_crypts_of1.13286811
74MP0003566_abnormal_cell_adhesion1.11869423
75MP0002332_abnormal_exercise_endurance1.09553948
76MP0003329_amyloid_beta_deposits1.08596877
77MP0005310_abnormal_salivary_gland1.06278753
78MP0002148_abnormal_hypersensitivity_rea1.06275047
79MP0002254_reproductive_system_inflammat1.04124117
80MP0005164_abnormal_response_to1.03699083
81MP0003656_abnormal_erythrocyte_physiolo1.03065065
82MP0003448_altered_tumor_morphology1.01857841
83MP0010307_abnormal_tumor_latency1.00477762
84MP0002019_abnormal_tumor_incidence1.00187680
85MP0001853_heart_inflammation0.99044080
86MP0005257_abnormal_intraocular_pressure0.98734201
87MP0008874_decreased_physiological_sensi0.97096255
88MP0003279_aneurysm0.92932478
89MP0006082_CNS_inflammation0.92049940
90MP0001730_embryonic_growth_arrest0.90233071
91MP0003879_abnormal_hair_cell0.88277407
92MP0003191_abnormal_cellular_cholesterol0.86954233
93MP0003091_abnormal_cell_migration0.85447350
94MP0005666_abnormal_adipose_tissue0.84401226
95MP0000609_abnormal_liver_physiology0.82924800
96MP0008469_abnormal_protein_level0.82131067
97MP0005390_skeleton_phenotype0.81290308
98MP0003950_abnormal_plasma_membrane0.81014518
99MP0005584_abnormal_enzyme/coenzyme_acti0.79080567
100MP0005375_adipose_tissue_phenotype0.77485711
101MP0009115_abnormal_fat_cell0.76348975
102MP0003705_abnormal_hypodermis_morpholog0.75828334
103MP0000249_abnormal_blood_vessel0.75042335
104MP0005595_abnormal_vascular_smooth0.75008496
105MP0005319_abnormal_enzyme/_coenzyme0.74786782
106MP0005360_urolithiasis0.74668844
107MP0000477_abnormal_intestine_morphology0.73323135
108MP0004130_abnormal_muscle_cell0.72637095
109MP0008770_decreased_survivor_rate0.72609840
110MP0005075_abnormal_melanosome_morpholog0.70347529
111MP0009763_increased_sensitivity_to0.70255839
112MP0010234_abnormal_vibrissa_follicle0.69754822
113MP0003186_abnormal_redox_activity0.68962111
114MP0005670_abnormal_white_adipose0.68920427
115MP0008057_abnormal_DNA_replication0.66952614
116MP0001533_abnormal_skeleton_physiology0.66910705
117MP0005647_abnormal_sex_gland0.66903132
118MP0001243_abnormal_dermal_layer0.66467402
119MP0003795_abnormal_bone_structure0.66301837
120MP0002877_abnormal_melanocyte_morpholog0.65314268
121MP0001764_abnormal_homeostasis0.65262854
122MP0002136_abnormal_kidney_physiology0.65133367
123MP0003077_abnormal_cell_cycle0.65012974
124MP0009643_abnormal_urine_homeostasis0.63603489
125MP0002132_abnormal_respiratory_system0.62571979
126MP0004019_abnormal_vitamin_homeostasis0.62358619
127MP0005535_abnormal_body_temperature0.62206995
128MP0000920_abnormal_myelination0.61429303
129MP0002970_abnormal_white_adipose0.61016033
130MP0001663_abnormal_digestive_system0.60980748
131MP0003453_abnormal_keratinocyte_physiol0.60532183
132MP0002089_abnormal_postnatal_growth/wei0.59959002
133MP0009765_abnormal_xenobiotic_induced0.59263062
134MP0004957_abnormal_blastocyst_morpholog0.57455483
135MP0000003_abnormal_adipose_tissue0.54409950
136MP0002086_abnormal_extraembryonic_tissu0.54400172
137MP0003787_abnormal_imprinting0.53113405
138MP0000350_abnormal_cell_proliferation0.53033355
139MP0003828_pulmonary_edema0.52025526
140MP0008873_increased_physiological_sensi0.48908616
141MP0009840_abnormal_foam_cell0.48030071
142MP0008877_abnormal_DNA_methylation0.47343503
143MP0002083_premature_death0.46069370
144MP0001784_abnormal_fluid_regulation0.45916400
145MP0000598_abnormal_liver_morphology0.45407867
146MP0000604_amyloidosis0.44926996

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.88100594
2Abnormality of T cell number (HP:0011839)8.32999349
3Abnormality of glycolipid metabolism (HP:0010969)7.78678887
4Abnormality of liposaccharide metabolism (HP:0010968)7.78678887
5Abnormality of glycosphingolipid metabolism (HP:0004343)7.78678887
6Systemic lupus erythematosus (HP:0002725)6.10345371
7Vacuolated lymphocytes (HP:0001922)5.84404341
8Abnormality of the fingertips (HP:0001211)5.39837605
9Abnormality of T cells (HP:0002843)5.27704014
10Disinhibition (HP:0000734)4.91696145
11Prolonged bleeding time (HP:0003010)4.89854845
12Dysostosis multiplex (HP:0000943)4.89390490
13Increased cerebral lipofuscin (HP:0011813)4.66435693
14Mutism (HP:0002300)4.58048023
15Pustule (HP:0200039)4.54658685
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.51078049
17Combined immunodeficiency (HP:0005387)4.47275909
18Recurrent viral infections (HP:0004429)4.41939884
19Severe combined immunodeficiency (HP:0004430)4.37180741
20Loss of speech (HP:0002371)4.35121690
21Abnormal platelet volume (HP:0011876)4.19579026
22Nuclear cataract (HP:0100018)4.14821828
23Panhypogammaglobulinemia (HP:0003139)4.11455698
24Axonal loss (HP:0003447)4.09403500
25IgM deficiency (HP:0002850)4.03788914
26Abnormality of macrophages (HP:0004311)3.99961613
27Elevated erythrocyte sedimentation rate (HP:0003565)3.98786219
28Glomerulonephritis (HP:0000099)3.96570782
29Autoimmune thrombocytopenia (HP:0001973)3.93284565
30Abnormality of polysaccharide metabolism (HP:0011012)3.76224074
31Abnormality of glycosaminoglycan metabolism (HP:0004371)3.76224074
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.76224074
33Increased neuronal autofluorescent lipopigment (HP:0002074)3.70424993
34Nasal polyposis (HP:0100582)3.68433423
35Increased mean platelet volume (HP:0011877)3.62999619
36Recurrent fungal infections (HP:0002841)3.59998926
37Mucopolysacchariduria (HP:0008155)3.53269650
38Urinary glycosaminoglycan excretion (HP:0003541)3.53269650
39Neurofibrillary tangles (HP:0002185)3.40454610
40Complement deficiency (HP:0004431)3.39954005
41Spontaneous hematomas (HP:0007420)3.35419181
42Menorrhagia (HP:0000132)3.34312176
43Thyroiditis (HP:0100646)3.24180363
44Abnormality of the vasculature of the conjunctiva (HP:0008054)3.23758024
45Epistaxis (HP:0000421)3.14290367
46Basal cell carcinoma (HP:0002671)3.13766164
47Chronic otitis media (HP:0000389)3.10340352
48Abnormality of the nasal mucosa (HP:0000433)3.09276990
49Recurrent abscess formation (HP:0002722)3.06282120
50Amyloidosis (HP:0011034)3.06266112
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.05774993
52Recurrent bacterial skin infections (HP:0005406)3.02612470
53Abnormality of complement system (HP:0005339)2.99846593
54Hyperacusis (HP:0010780)2.96389428
55Recurrent bronchitis (HP:0002837)2.94776754
56Abnormality of eosinophils (HP:0001879)2.94469011
57Asymmetric septal hypertrophy (HP:0001670)2.89154755
58Apathy (HP:0000741)2.88722494
59Increased IgE level (HP:0003212)2.88253315
60Broad palm (HP:0001169)2.85801127
61Verrucae (HP:0200043)2.83388600
62Papilloma (HP:0012740)2.83388600
63Diminished motivation (HP:0000745)2.74678492
64Prolonged neonatal jaundice (HP:0006579)2.71656346
65Eosinophilia (HP:0001880)2.67924652
66Orchitis (HP:0100796)2.64719578
67Progressive neurologic deterioration (HP:0002344)2.62652392
68Joint swelling (HP:0001386)2.59025790
69Bilateral sensorineural hearing impairment (HP:0008619)2.58050588
70Aortic aneurysm (HP:0004942)2.56182745
71Impaired platelet aggregation (HP:0003540)2.55251741
72Abnormal platelet function (HP:0011869)2.55251741
73Gastrointestinal inflammation (HP:0004386)2.54711474
74Upper motor neuron abnormality (HP:0002127)2.54397489
75Leukocytosis (HP:0001974)2.54189241
76Purpura (HP:0000979)2.52142568
77Inappropriate behavior (HP:0000719)2.50523333
78Inflammation of the large intestine (HP:0002037)2.50199785
79Thin bony cortex (HP:0002753)2.49992053
80Nephritis (HP:0000123)2.46645481
81Eczematoid dermatitis (HP:0000976)2.46292571
82Increased density of long bones (HP:0006392)2.45674363
83Personality changes (HP:0000751)2.45520916
84Malnutrition (HP:0004395)2.44813155
85Hypoplasia of the thymus (HP:0000778)2.44601092
86Cerebral inclusion bodies (HP:0100314)2.42285417
87Abnormality of oral frenula (HP:0000190)2.42284399
88Neuronal loss in central nervous system (HP:0002529)2.39602314
89Agnosia (HP:0010524)2.38832378
90Myositis (HP:0100614)2.38492650
91Abnormality of T cell physiology (HP:0011840)2.37894194
92Increased serum ferritin (HP:0003281)2.37131556
93Vertebral compression fractures (HP:0002953)2.35749098
94Granulocytopenia (HP:0001913)2.35354007
95Progressive hearing impairment (HP:0001730)2.34373352
96Metaphyseal irregularity (HP:0003025)2.33400033
97Lymphopenia (HP:0001888)2.30736955
98Hematochezia (HP:0002573)2.29253127
99Nausea (HP:0002018)2.27971662
100Seborrheic dermatitis (HP:0001051)2.27282497
101Bicuspid aortic valve (HP:0001647)2.27256494
102Retrobulbar optic neuritis (HP:0100654)2.26897999
103Optic neuritis (HP:0100653)2.26897999
104Dementia (HP:0000726)2.26637692
105Cardiomegaly (HP:0001640)2.26586149
106Macroorchidism (HP:0000053)2.26251632
107Gingivitis (HP:0000230)2.22898964
108Abnormality of cells of the lymphoid lineage (HP:0012140)2.22776426
109Frequent falls (HP:0002359)2.22400818
110Myocardial infarction (HP:0001658)2.20501619
111IgG deficiency (HP:0004315)2.20227737
112Mediastinal lymphadenopathy (HP:0100721)2.19876488
113Hepatosplenomegaly (HP:0001433)2.19740321
114Peripheral demyelination (HP:0011096)2.17356459
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15618463
116Ureteral stenosis (HP:0000071)2.12785324
117Gingival bleeding (HP:0000225)2.09318428
118Recurrent gram-negative bacterial infections (HP:0005420)2.06187578
119Obstructive lung disease (HP:0006536)2.06107348
120Chronic obstructive pulmonary disease (HP:0006510)2.06107348
121Conjunctival telangiectasia (HP:0000524)2.05439440
122Narrow palate (HP:0000189)2.02456830
123Chronic mucocutaneous candidiasis (HP:0002728)2.01658345
124Recurrent cutaneous fungal infections (HP:0011370)2.01658345
125Subcapsular cataract (HP:0000523)2.01325416
126Broad metatarsal (HP:0001783)1.98708032
127Premature skin wrinkling (HP:0100678)1.97423166
128Bone pain (HP:0002653)1.96756443
129Meningitis (HP:0001287)1.96433527
130Polyneuropathy (HP:0001271)1.94428833
131Pathologic fracture (HP:0002756)1.94050630
132Interstitial pulmonary disease (HP:0006530)1.93002224
133Stomatitis (HP:0010280)1.92639772
134Basal ganglia calcification (HP:0002135)1.92629610
135Supranuclear gaze palsy (HP:0000605)1.91599128
136Chronic diarrhea (HP:0002028)1.90823230
137Persistence of primary teeth (HP:0006335)1.89584841
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.87266118
139Skin tags (HP:0010609)1.87219702
140Anal stenosis (HP:0002025)1.86492303
141Thrombocytosis (HP:0001894)1.86343171
142Pulmonary embolism (HP:0002204)1.85933875
143Tetraparesis (HP:0002273)1.84534580
144Pulmonary infiltrates (HP:0002113)1.84311871
145Zonular cataract (HP:0010920)1.83669364
146Ureteral obstruction (HP:0006000)1.83365376
147Abnormal number of erythroid precursors (HP:0012131)1.82572581
148Abnormality of glutamine family amino acid metabolism (HP:0010902)1.82474903
149Retinal atrophy (HP:0001105)1.81575431
150Hypertensive crisis (HP:0100735)1.81558282
151Spinal canal stenosis (HP:0003416)1.80401076
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80089373
153Abnormality of cells of the erythroid lineage (HP:0012130)1.79708140
154Hypokinesia (HP:0002375)1.79549664
155Abnormality of iron homeostasis (HP:0011031)1.79392827
156Prominent nose (HP:0000448)1.77712588
157Hypochromic anemia (HP:0001931)1.76999513
158Hypoalphalipoproteinemia (HP:0003233)1.76497443
159High pitched voice (HP:0001620)1.75708331
160Cerebral aneurysm (HP:0004944)1.75268579
161Urinary urgency (HP:0000012)1.74769929
162Mitral regurgitation (HP:0001653)1.73830799
163Hydroxyprolinuria (HP:0003080)1.73324322
164Abnormality of proline metabolism (HP:0010907)1.73324322
165Beaking of vertebral bodies (HP:0004568)1.73058072
166Thoracolumbar scoliosis (HP:0002944)1.72282260
167Heterotopia (HP:0002282)1.71452052
168Sparse lateral eyebrow (HP:0005338)1.71296986
169Vertebral arch anomaly (HP:0008438)1.70903205
170Abnormality of lateral ventricle (HP:0030047)1.69836824
171Abnormality of the basal ganglia (HP:0002134)1.69163445
172Depressed nasal tip (HP:0000437)1.67590588
173Autoimmune hemolytic anemia (HP:0001890)1.66976287
174Encephalitis (HP:0002383)1.66568346
175Pseudobulbar signs (HP:0002200)1.65973477
176Mucosal telangiectasiae (HP:0100579)1.65626117
177Lymphoma (HP:0002665)1.65331605
178Increased CSF protein (HP:0002922)1.63544810
179Protuberant abdomen (HP:0001538)1.63349782
180Microcytic anemia (HP:0001935)1.63240314
181Dilatation of the ascending aorta (HP:0005111)1.63075142
182Generalized aminoaciduria (HP:0002909)1.62739767
183Petechiae (HP:0000967)1.62353065
184Recurrent otitis media (HP:0000403)1.61951245
185Delayed closure of the anterior fontanelle (HP:0001476)1.60984867
186Striae distensae (HP:0001065)1.60626224
187B lymphocytopenia (HP:0010976)1.60402216
188Global brain atrophy (HP:0002283)1.60158386
189Severe visual impairment (HP:0001141)1.60073224
190Bone cyst (HP:0012062)1.59176686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.49896871
2IRAK34.47756186
3EEF2K4.30368165
4TXK4.01014125
5MAP3K103.57955242
6STK103.45417559
7DDR23.27385200
8GRK62.99808880
9RIPK12.94211838
10GRK72.73085676
11MST1R2.65388882
12ITK2.59337561
13TAOK22.57038155
14ERN12.50561566
15MAP3K32.48254762
16ACVR1B2.39415095
17JAK32.37847739
18PIM22.35116427
19SIK22.29830837
20MAP3K112.19691073
21ARAF2.16447162
22MOS2.15046674
23ZAP702.11678287
24TRPM72.05666298
25PKN21.93581839
26MAP3K71.91785726
27ABL21.88663116
28MAP3K131.86082647
29FGFR41.83933734
30MARK31.71973018
31PRKCH1.69695068
32CSK1.68103612
33TRIB31.61351204
34MATK1.59540201
35TYK21.56617786
36TNK21.56291461
37TESK21.53928564
38LRRK21.53061179
39FGFR31.49033648
40EPHB11.48880088
41LCK1.39931339
42FGFR21.36580071
43MARK21.36229397
44MAP3K11.35996325
45TTN1.34228511
46MST41.31091800
47CLK11.29197767
48ALK1.28990117
49PRPF4B1.28840717
50RIPK41.28831437
51SYK1.28664148
52PAK41.27478580
53FES1.25218011
54BTK1.23168236
55TYRO31.22573644
56HCK1.22065956
57MAP2K31.19217042
58EPHB21.17137814
59PLK41.15394753
60CAMKK21.14677665
61CDC42BPA1.14041131
62FGR1.12748834
63RPS6KB21.09413225
64EPHA21.09179169
65CDK121.08142543
66KDR1.07048787
67MAP3K141.05239662
68PTK60.99791143
69PIM10.97854252
70CDK40.96450556
71IRAK40.95306354
72JAK20.93880231
73PRKCQ0.93449656
74IKBKE0.91688141
75BLK0.90133647
76TAOK10.89294051
77PRKD20.88788794
78NLK0.86249905
79PRKG20.85218843
80PDGFRB0.84879311
81HIPK20.84441638
82CHUK0.79194296
83JAK10.78798136
84PDK10.77565923
85BRAF0.76913261
86MAP3K120.76321957
87LATS20.76311547
88SIK10.74733646
89ADRBK20.73492376
90CAMK1D0.71397822
91BMPR20.70533848
92MAP3K50.66415444
93TEC0.66250828
94PDPK10.66062118
95STK110.65068673
96PBK0.63304207
97MAP2K60.60001375
98MET0.57318841
99NME20.57241899
100NEK20.55828586
101DMPK0.53744394
102ICK0.51280819
103MAP3K90.49722900
104STK40.49596409
105MYLK0.49199755
106PDGFRA0.48659567
107FYN0.47517537
108MAPK40.47264667
109NTRK20.47223383
110CSF1R0.46800442
111LYN0.46221241
112TAOK30.46107597
113INSRR0.45719930
114PRKD10.45178877
115TBK10.43717604
116TGFBR20.42362079
117MAPK120.42320089
118LIMK10.42095681
119RET0.41747582
120KSR20.41255301
121MELK0.41254867
122CDK60.40461803
123TGFBR10.39502232
124CDK190.38127331
125FGFR10.37310840
126SRC0.37012942
127BMX0.36864359
128DAPK30.35648271
129MAP3K80.35597293
130TESK10.34765423
131PASK0.32724741
132CDC70.32263174
133UHMK10.32035996
134SIK30.31615820
135SCYL20.30971209
136ABL10.29385547
137INSR0.29293721
138PAK10.28889351
139LMTK20.28510642
140PRKAA20.28070664
141MTOR0.27553358
142DYRK1B0.26830576
143MAPKAPK20.25294337
144RPS6KA40.24251964
145IKBKB0.23264267
146MAPK90.22851799
147MAPK70.22750679
148CAMK1G0.22680684
149PRKCB0.21987122
150RPS6KA60.21444788
151CAMK2G0.21076660
152ROCK20.20886952
153MAPK110.20309774
154RPS6KC10.20262113
155STK380.19402804
156DAPK10.17808396
157IRAK20.15953754
158CDK140.15184708
159EGFR0.15069299
160BCKDK0.14667422
161NEK90.12605872

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.25297478
2Other glycan degradation_Homo sapiens_hsa005114.75221424
3T cell receptor signaling pathway_Homo sapiens_hsa046604.33387062
4Lysosome_Homo sapiens_hsa041423.48134508
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.30624291
6Asthma_Homo sapiens_hsa053102.68476621
7Rheumatoid arthritis_Homo sapiens_hsa053232.55663511
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.49583092
9Allograft rejection_Homo sapiens_hsa053302.48406793
10Measles_Homo sapiens_hsa051622.20095551
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.19203815
12Pertussis_Homo sapiens_hsa051332.12920724
13B cell receptor signaling pathway_Homo sapiens_hsa046622.10147134
14Antigen processing and presentation_Homo sapiens_hsa046122.03072193
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02649527
16Leukocyte transendothelial migration_Homo sapiens_hsa046702.01627463
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98612748
18Autoimmune thyroid disease_Homo sapiens_hsa053201.95122466
19Osteoclast differentiation_Homo sapiens_hsa043801.94674904
20Tuberculosis_Homo sapiens_hsa051521.93472582
21Acute myeloid leukemia_Homo sapiens_hsa052211.88418576
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86861328
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.85594957
24Platelet activation_Homo sapiens_hsa046111.77664659
25Phagosome_Homo sapiens_hsa041451.75254332
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.73119855
27Legionellosis_Homo sapiens_hsa051341.69742489
28Malaria_Homo sapiens_hsa051441.67881892
29Chemokine signaling pathway_Homo sapiens_hsa040621.64856695
30Sulfur metabolism_Homo sapiens_hsa009201.63934315
31Mineral absorption_Homo sapiens_hsa049781.62818257
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61073908
33Ribosome_Homo sapiens_hsa030101.59284445
34Chronic myeloid leukemia_Homo sapiens_hsa052201.57236796
35Viral myocarditis_Homo sapiens_hsa054161.52830966
36Type I diabetes mellitus_Homo sapiens_hsa049401.52822173
37Leishmaniasis_Homo sapiens_hsa051401.48570167
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48166165
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44847107
40Hematopoietic cell lineage_Homo sapiens_hsa046401.42978411
41Colorectal cancer_Homo sapiens_hsa052101.41317237
42Non-small cell lung cancer_Homo sapiens_hsa052231.40854273
43Prion diseases_Homo sapiens_hsa050201.39870795
44Complement and coagulation cascades_Homo sapiens_hsa046101.35761405
45HTLV-I infection_Homo sapiens_hsa051661.31260395
46VEGF signaling pathway_Homo sapiens_hsa043701.29867461
47Pancreatic cancer_Homo sapiens_hsa052121.27677747
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24099394
49Renin-angiotensin system_Homo sapiens_hsa046141.23415830
50Lysine degradation_Homo sapiens_hsa003101.21579459
51Hepatitis B_Homo sapiens_hsa051611.20420087
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.18729739
53Galactose metabolism_Homo sapiens_hsa000521.16259127
54African trypanosomiasis_Homo sapiens_hsa051431.15416968
55Staphylococcus aureus infection_Homo sapiens_hsa051501.14659489
56Sphingolipid metabolism_Homo sapiens_hsa006001.13202197
57Graft-versus-host disease_Homo sapiens_hsa053321.12098189
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09803618
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09261278
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06721198
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04218712
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03295147
63PPAR signaling pathway_Homo sapiens_hsa033201.01842910
64Shigellosis_Homo sapiens_hsa051310.96760126
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.95596958
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95218982
67Spliceosome_Homo sapiens_hsa030400.94422489
68Fructose and mannose metabolism_Homo sapiens_hsa000510.93755142
69Bladder cancer_Homo sapiens_hsa052190.93074602
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93059373
71Herpes simplex infection_Homo sapiens_hsa051680.91536210
72Long-term potentiation_Homo sapiens_hsa047200.91146472
73Collecting duct acid secretion_Homo sapiens_hsa049660.90728935
74mTOR signaling pathway_Homo sapiens_hsa041500.89807856
75Notch signaling pathway_Homo sapiens_hsa043300.89624682
76Toxoplasmosis_Homo sapiens_hsa051450.88045434
77Vibrio cholerae infection_Homo sapiens_hsa051100.85832300
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85045781
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84803193
80Endometrial cancer_Homo sapiens_hsa052130.83690959
81Insulin resistance_Homo sapiens_hsa049310.83473945
82Rap1 signaling pathway_Homo sapiens_hsa040150.82889421
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82009832
84Gastric acid secretion_Homo sapiens_hsa049710.79007701
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.78119466
86Glutathione metabolism_Homo sapiens_hsa004800.76885791
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76266401
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.76140780
89Estrogen signaling pathway_Homo sapiens_hsa049150.76076337
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75561393
91Choline metabolism in cancer_Homo sapiens_hsa052310.75011081
92Fatty acid biosynthesis_Homo sapiens_hsa000610.74811297
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.73708835
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.73318935
95Apoptosis_Homo sapiens_hsa042100.72530866
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71409132
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.70956973
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70890747
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70316496
100Salmonella infection_Homo sapiens_hsa051320.68384379
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68130145
102Viral carcinogenesis_Homo sapiens_hsa052030.67688173
103Glioma_Homo sapiens_hsa052140.67514295
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66768239
105MAPK signaling pathway_Homo sapiens_hsa040100.66638333
106mRNA surveillance pathway_Homo sapiens_hsa030150.64168421
107Amoebiasis_Homo sapiens_hsa051460.64051404
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62861813
109Influenza A_Homo sapiens_hsa051640.62566019
110Thyroid cancer_Homo sapiens_hsa052160.59620070
111Endocytosis_Homo sapiens_hsa041440.59298407
112Proteoglycans in cancer_Homo sapiens_hsa052050.59159145
113FoxO signaling pathway_Homo sapiens_hsa040680.59004368
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58196388
115Renal cell carcinoma_Homo sapiens_hsa052110.58032436
116Epstein-Barr virus infection_Homo sapiens_hsa051690.56646195
117Hepatitis C_Homo sapiens_hsa051600.55186658
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55041748
119Dorso-ventral axis formation_Homo sapiens_hsa043200.54731220
120Non-homologous end-joining_Homo sapiens_hsa034500.54634014
121Focal adhesion_Homo sapiens_hsa045100.54444599
122ErbB signaling pathway_Homo sapiens_hsa040120.54217206
123Tryptophan metabolism_Homo sapiens_hsa003800.53521490
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53375930
125DNA replication_Homo sapiens_hsa030300.52717601
126Oxytocin signaling pathway_Homo sapiens_hsa049210.51535616
127TNF signaling pathway_Homo sapiens_hsa046680.50653026
128Prolactin signaling pathway_Homo sapiens_hsa049170.50605382
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50153776
130Prostate cancer_Homo sapiens_hsa052150.48274902
131Vitamin digestion and absorption_Homo sapiens_hsa049770.47637387
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45913960
133MicroRNAs in cancer_Homo sapiens_hsa052060.45412735
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45118054
135Pathways in cancer_Homo sapiens_hsa052000.44925801
136Glucagon signaling pathway_Homo sapiens_hsa049220.43000296
137Starch and sucrose metabolism_Homo sapiens_hsa005000.42964490
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.42657335
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.42549279
140Chemical carcinogenesis_Homo sapiens_hsa052040.41876964
141Renin secretion_Homo sapiens_hsa049240.41374133
142Type II diabetes mellitus_Homo sapiens_hsa049300.41135973
143Morphine addiction_Homo sapiens_hsa050320.39543278
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38913509
145Small cell lung cancer_Homo sapiens_hsa052220.38896275
146Cholinergic synapse_Homo sapiens_hsa047250.37704094
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37534448
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35807964
149Proteasome_Homo sapiens_hsa030500.29833345
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28992899
151HIF-1 signaling pathway_Homo sapiens_hsa040660.27801742
152Fat digestion and absorption_Homo sapiens_hsa049750.23884787
153Synaptic vesicle cycle_Homo sapiens_hsa047210.23841644
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.23612057
155Folate biosynthesis_Homo sapiens_hsa007900.21267904
156Systemic lupus erythematosus_Homo sapiens_hsa053220.19661070
157Arachidonic acid metabolism_Homo sapiens_hsa005900.18318315
158Protein digestion and absorption_Homo sapiens_hsa049740.14826147

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »