CD164L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.92362415
2left/right pattern formation (GO:0060972)9.29993944
3primary alcohol catabolic process (GO:0034310)7.77376203
4proline biosynthetic process (GO:0006561)7.63821812
5regulation of cilium movement (GO:0003352)7.52524683
6vitamin transmembrane transport (GO:0035461)7.10919442
7base-excision repair, AP site formation (GO:0006285)6.66327253
8ventricular system development (GO:0021591)6.63675884
9left/right axis specification (GO:0070986)6.62928283
10ethanol metabolic process (GO:0006067)6.53099542
11microtubule bundle formation (GO:0001578)6.36857979
12diterpenoid biosynthetic process (GO:0016102)6.34739786
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.33682990
14regulation of female gonad development (GO:2000194)6.31020324
15replication fork processing (GO:0031297)6.28288372
16piRNA metabolic process (GO:0034587)6.20350981
17intraciliary transport (GO:0042073)6.04700585
18one-carbon compound transport (GO:0019755)5.84570330
19cilium organization (GO:0044782)5.71326208
20cilium assembly (GO:0042384)5.55158027
21pyrimidine-containing compound transmembrane transport (GO:0072531)5.52426460
22proline metabolic process (GO:0006560)5.51590173
23tolerance induction (GO:0002507)5.50699672
24transcription from mitochondrial promoter (GO:0006390)5.45030800
25pyrimidine nucleotide catabolic process (GO:0006244)5.43242325
26lung epithelium development (GO:0060428)5.41393954
27centriole assembly (GO:0098534)5.34334721
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.17922503
29negative regulation of T cell differentiation in thymus (GO:0033085)5.14519842
30sperm capacitation (GO:0048240)4.98434429
31response to xenobiotic stimulus (GO:0009410)4.87576320
32glomerular epithelial cell development (GO:0072310)4.86631428
33oxidative demethylation (GO:0070989)4.81391339
34ethanol oxidation (GO:0006069)4.79884075
35regulation of sister chromatid cohesion (GO:0007063)4.78363437
36negative regulation of B cell mediated immunity (GO:0002713)4.72642588
37negative regulation of immunoglobulin mediated immune response (GO:0002890)4.72642588
38protein localization to cilium (GO:0061512)4.68172903
39histone H2A monoubiquitination (GO:0035518)4.55582903
40negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.55001712
41histone H2A ubiquitination (GO:0033522)4.54420104
42microtubule-based movement (GO:0007018)4.51168513
43regulation of meiosis (GO:0040020)4.51110175
44maturation of 5.8S rRNA (GO:0000460)4.49832954
45negative regulation of humoral immune response (GO:0002921)4.49396662
46DNA deamination (GO:0045006)4.46458599
47positive regulation of protein homooligomerization (GO:0032464)4.45414301
48negative regulation of meiosis (GO:0045835)4.43877854
49terpenoid biosynthetic process (GO:0016114)4.43260034
50female gamete generation (GO:0007292)4.42334884
51regulation of interleukin-5 production (GO:0032674)4.38085289
52embryonic process involved in female pregnancy (GO:0060136)4.37922319
53cellular component assembly involved in morphogenesis (GO:0010927)4.36601806
54positive regulation of tolerance induction (GO:0002645)4.35008787
55regulation of microtubule-based movement (GO:0060632)4.33388071
56poly(A)+ mRNA export from nucleus (GO:0016973)4.31817216
57regulation of germinal center formation (GO:0002634)4.31670897
58negative regulation of meiotic cell cycle (GO:0051447)4.21290095
59meiotic chromosome segregation (GO:0045132)4.19125823
60retinoic acid metabolic process (GO:0042573)4.16588080
61protein deneddylation (GO:0000338)4.15391811
62cell projection assembly (GO:0030031)4.10105628
63protein K6-linked ubiquitination (GO:0085020)4.09663421
64nucleoside diphosphate phosphorylation (GO:0006165)4.06418452
65cilium morphogenesis (GO:0060271)3.97749280
66cytoplasmic microtubule organization (GO:0031122)3.97079448
67regulation of interleukin-13 production (GO:0032656)3.93712812
68DNA strand renaturation (GO:0000733)3.92617457
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.91130822
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.91130822
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.91130822
72regulation of integrin activation (GO:0033623)3.89273075
73glandular epithelial cell development (GO:0002068)3.86945891
74mitotic metaphase plate congression (GO:0007080)3.85956520
75establishment of apical/basal cell polarity (GO:0035089)3.85454192
76negative regulation of JAK-STAT cascade (GO:0046426)3.82555519
77mitotic sister chromatid segregation (GO:0000070)3.81912619
78regulation of protein homooligomerization (GO:0032462)3.80010736
79regulation of DNA methylation (GO:0044030)3.79829700
80regulation of meiotic cell cycle (GO:0051445)3.79157213
81DNA methylation involved in gamete generation (GO:0043046)3.69941403
82microtubule depolymerization (GO:0007019)3.69383922
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.68745187
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.68745187
85exogenous drug catabolic process (GO:0042738)3.68520557
86negative regulation of reproductive process (GO:2000242)3.66974115
87negative regulation of cell cycle arrest (GO:0071157)3.63626755
88meiotic cell cycle (GO:0051321)3.62663502
89base-excision repair (GO:0006284)3.60797193
90negative regulation of inclusion body assembly (GO:0090084)3.60219214
91mitochondrial DNA metabolic process (GO:0032042)3.59451079
92establishment of tissue polarity (GO:0007164)3.59164178
93establishment of planar polarity (GO:0001736)3.59164178
94multicellular organismal water homeostasis (GO:0050891)3.58697075
95microtubule polymerization or depolymerization (GO:0031109)3.54453706
96primary alcohol metabolic process (GO:0034308)3.54246873
97pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.51500992
98protein retention in ER lumen (GO:0006621)3.47478621
99positive regulation of chromosome segregation (GO:0051984)3.46943589
100columnar/cuboidal epithelial cell development (GO:0002066)3.44237470
101retinol metabolic process (GO:0042572)3.40681112
102establishment or maintenance of monopolar cell polarity (GO:0061339)3.32596052
103establishment of monopolar cell polarity (GO:0061162)3.32596052
104intestinal epithelial cell development (GO:0060576)3.31794098
105regulation of cAMP-dependent protein kinase activity (GO:2000479)3.31176029
106maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.28303299
107resolution of meiotic recombination intermediates (GO:0000712)3.27080936
108regulation of tolerance induction (GO:0002643)3.26173240
109O-glycan processing (GO:0016266)3.26107469
110regulation of meiosis I (GO:0060631)3.23703162
111oocyte maturation (GO:0001556)3.22581718
112negative regulation of smooth muscle cell differentiation (GO:0051151)3.21907499
113GDP-mannose metabolic process (GO:0019673)3.21201311
114glutathione derivative biosynthetic process (GO:1901687)3.20679178
115glutathione derivative metabolic process (GO:1901685)3.20679178
116lateral ventricle development (GO:0021670)3.20530631
117non-recombinational repair (GO:0000726)3.19448883
118double-strand break repair via nonhomologous end joining (GO:0006303)3.19448883
119regulation of microtubule depolymerization (GO:0031114)3.19334123
120mitotic chromosome condensation (GO:0007076)3.18209808
121attachment of spindle microtubules to kinetochore (GO:0008608)3.18014324
122male meiosis (GO:0007140)3.16687005
123regulation of early endosome to late endosome transport (GO:2000641)3.15980885
124regulation of double-strand break repair via homologous recombination (GO:0010569)3.15111694
125cullin deneddylation (GO:0010388)3.14604032
126protein polyglutamylation (GO:0018095)3.14574415
127aldehyde catabolic process (GO:0046185)3.14327252
128citrulline biosynthetic process (GO:0019240)3.13512667
129metaphase plate congression (GO:0051310)3.12186371
130hydrogen peroxide biosynthetic process (GO:0050665)3.11267248
131kinetochore assembly (GO:0051382)3.10271810
132phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.09833852
133positive regulation of smoothened signaling pathway (GO:0045880)3.08945864
134hypotonic response (GO:0006971)3.06464658
135viral mRNA export from host cell nucleus (GO:0046784)3.02989376
136water homeostasis (GO:0030104)3.02184894
137notochord development (GO:0030903)3.00556662
138axonemal dynein complex assembly (GO:0070286)22.4003232
139hydrogen peroxide catabolic process (GO:0042744)2.99510808
140negative regulation of Ras GTPase activity (GO:0034261)2.99426065
141regulation of response to osmotic stress (GO:0047484)2.99040611
142regulation of exit from mitosis (GO:0007096)2.97374998
143chromosome segregation (GO:0007059)2.96830112
144sister chromatid segregation (GO:0000819)2.91376516
145gene silencing by RNA (GO:0031047)2.91155716
146negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.90372295
147positive regulation of T cell apoptotic process (GO:0070234)2.90133483
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89755847
149carnitine metabolic process (GO:0009437)2.85528694
150oogenesis (GO:0048477)2.85492807
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.85174931
152DNA damage response, signal transduction resulting in transcription (GO:0042772)2.84101169
153convergent extension (GO:0060026)2.83614017
154sperm motility (GO:0030317)2.82735870
155cellular response to ATP (GO:0071318)2.82232566
156mitotic G1 DNA damage checkpoint (GO:0031571)2.81730008
157regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.81524479
158oligosaccharide biosynthetic process (GO:0009312)2.80853126
159DNA integration (GO:0015074)2.80703382
160regulation of spindle checkpoint (GO:0090231)2.80337915
161lateral sprouting from an epithelium (GO:0060601)2.80038247
162negative regulation of chromosome segregation (GO:0051985)2.79583549
163DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.78136404
164drug catabolic process (GO:0042737)2.78125951
165regulation of autophagic vacuole assembly (GO:2000785)2.77076154
166activation of Rac GTPase activity (GO:0032863)2.75722102
167reactive oxygen species biosynthetic process (GO:1903409)2.75541197
168excretion (GO:0007588)2.75493919
169negative regulation of viral release from host cell (GO:1902187)2.74803072
170progesterone metabolic process (GO:0042448)2.73454003
171apical protein localization (GO:0045176)2.72458791
172mRNA polyadenylation (GO:0006378)2.71963524
173establishment of chromosome localization (GO:0051303)2.70872492
174calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.70333768
175microtubule-based process (GO:0007017)2.68038372
176DNA modification (GO:0006304)2.66878439
177negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65580542
178determination of left/right symmetry (GO:0007368)2.64574153
179COPII vesicle coating (GO:0048208)2.64209513
180dosage compensation (GO:0007549)2.63759402
181dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62285119
182establishment or maintenance of bipolar cell polarity (GO:0061245)2.60855477
183establishment or maintenance of apical/basal cell polarity (GO:0035088)2.60855477
184polyol transport (GO:0015791)2.60463210
185hydrogen peroxide metabolic process (GO:0042743)2.59163984
186negative regulation of microtubule depolymerization (GO:0007026)2.57559881
187centriole replication (GO:0007099)2.57552657
188phosphatidylcholine biosynthetic process (GO:0006656)2.56788944
189determination of bilateral symmetry (GO:0009855)2.54844554
190iron ion import (GO:0097286)2.51250967
191specification of symmetry (GO:0009799)2.50742662
192organelle assembly (GO:0070925)2.46731523
193cilium or flagellum-dependent cell motility (GO:0001539)17.5411029
194cilium movement (GO:0003341)15.5051788
195motile cilium assembly (GO:0044458)15.2563443
196epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.7639123
197epithelial cilium movement (GO:0003351)13.5472279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.20735739
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.07998810
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.38663563
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.32344188
5NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.17666525
6DROSHA_22980978_ChIP-Seq_HELA_Human3.13396439
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10524213
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92094570
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.90293081
10DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.53882837
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.42701356
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.34566716
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.34566716
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.34566716
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.33597124
16NANOG_21062744_ChIP-ChIP_HESCs_Human2.33513030
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.32776599
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.23948925
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22381657
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.21866103
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18454007
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.17958433
23RUNX1_27514584_Chip-Seq_MCF-7_Human2.17111011
24SMC4_20622854_ChIP-Seq_HELA_Human2.13741968
25SOX2_27498859_Chip-Seq_STOMACH_Mouse2.12765490
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.09808282
27ESR1_21235772_ChIP-Seq_MCF-7_Human2.09351998
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05116893
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.03106667
30TP63_17297297_ChIP-ChIP_HaCaT_Human2.01195466
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96439973
32FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.90762401
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90250634
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.89809898
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89669894
36GABP_19822575_ChIP-Seq_HepG2_Human1.83542068
37* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83182657
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82515019
39PU.1_20513432_ChIP-Seq_Bcells_Mouse1.82339134
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82056202
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.79521447
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79095916
43* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77299064
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.77218110
45TP63_22573176_ChIP-Seq_HFKS_Human1.76313550
46POU5F1_16518401_ChIP-PET_MESCs_Mouse1.74910594
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70865542
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.70699719
49AHR_22903824_ChIP-Seq_MCF-7_Human1.70418268
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.69637910
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67441652
52KLF5_25053715_ChIP-Seq_YYC3_Human1.67406312
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65011150
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.64175599
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63257159
56SOX2_20726797_ChIP-Seq_SW620_Human1.60973521
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60856010
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58967576
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58216122
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57957532
61RAD21_21589869_ChIP-Seq_MESCs_Mouse1.57364612
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56163399
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55466667
64TP63_23658742_ChIP-Seq_EP156T_Human1.55325200
65P68_20966046_ChIP-Seq_HELA_Human1.51715322
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50299652
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49211514
68* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.48042688
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.47191306
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46860668
71SPI1_26923725_Chip-Seq_HPCs_Mouse1.45978307
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45465260
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45266308
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45254076
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43586067
76GATA1_19941826_ChIP-Seq_K562_Human1.41720957
77TDRD3_21172665_ChIP-Seq_MCF-7_Human1.41539453
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40891822
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40681760
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.40644909
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39707241
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39602618
83CREB1_26743006_Chip-Seq_LNCaP_Human1.38660336
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.37614149
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37552798
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36778843
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.35765474
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.35294259
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34954343
90KDM5A_27292631_Chip-Seq_BREAST_Human1.34341738
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34257790
92KAP1_27257070_Chip-Seq_ESCs_Mouse1.33942917
93LXR_22292898_ChIP-Seq_THP-1_Human1.33685585
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32339455
95TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31778264
96FOXA1_25552417_ChIP-Seq_VCAP_Human1.31581686
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31568781
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31563286
99* CTCF_27219007_Chip-Seq_Bcells_Human1.30828575
100NANOG_18692474_ChIP-Seq_MESCs_Mouse1.30193288
101RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28780694
102PHF8_20622854_ChIP-Seq_HELA_Human1.28598615
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27853145
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.27117094
105GATA3_24758297_ChIP-Seq_MCF-7_Human1.26923134
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26666322
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26215463
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26147134
109FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24712404
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.24133759
111STAT1_20625510_ChIP-Seq_HELA_Human1.23852742
112MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23614646
113ETS1_20019798_ChIP-Seq_JURKAT_Human1.22586794
114MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21603576
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20970035
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20572578
117GATA4_25053715_ChIP-Seq_YYC3_Human1.20195851
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20025459
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19502294
120* CTCF_20526341_ChIP-Seq_ESCs_Human1.19308469
121DCP1A_22483619_ChIP-Seq_HELA_Human1.19142282
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.18958512
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18600527
124TET1_21490601_ChIP-Seq_MESCs_Mouse1.17061403
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.16953810
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16596954
127VDR_21846776_ChIP-Seq_THP-1_Human1.16432646
128ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16063043
129* ETV1_20927104_ChIP-Seq_GIST48_Human1.15741428
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13751732
131AR_21909140_ChIP-Seq_LNCAP_Human1.13542677
132E2F1_21310950_ChIP-Seq_MCF-7_Human1.12622451
133SMRT_27268052_Chip-Seq_Bcells_Human1.10612408
134* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09958061
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09591531
136* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09449361
137ETS1_21867929_ChIP-Seq_TH2_Mouse1.09105725
138YY1_21170310_ChIP-Seq_MESCs_Mouse1.08533343
139P300_27268052_Chip-Seq_Bcells_Human1.08354292
140* HNFA_21074721_ChIP-Seq_CACO-2_Human1.08169652
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08053554
142* PHF8_20622853_ChIP-Seq_HELA_Human1.07796247
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07356103
144E2F1_20622854_ChIP-Seq_HELA_Human1.06754270
145RARB_24833708_ChIP-Seq_LIVER_Mouse1.06196175
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06097659
147RACK7_27058665_Chip-Seq_MCF-7_Human1.05985244
148MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05257728
149FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04594205
150PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03859290
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03513948
152* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03471471
153THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00806896
154CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00387478
155NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00385088
156BCOR_27268052_Chip-Seq_Bcells_Human1.00083701
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99930894
158* RBPJ_21746931_ChIP-Seq_IB4_Human0.99681888
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99600601
160PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99118309
161RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98172845
162TP53_18474530_ChIP-ChIP_U2OS_Human0.97236831
163SOX2_21211035_ChIP-Seq_LN229_Human0.97228251
164CEBPB_22108803_ChIP-Seq_LS180_Human0.97221150
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.96624325
166RARA_24833708_ChIP-Seq_LIVER_Mouse0.95864265
167* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95090329
168VDR_22108803_ChIP-Seq_LS180_Human0.95063811
169SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94878626
170NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94520034
171* GATA6_21074721_ChIP-Seq_CACO-2_Human0.94469506
172SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93786077
173SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93627438
174NANOG_16518401_ChIP-PET_MESCs_Mouse0.93404596
175STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93318976
176FOXA2_19822575_ChIP-Seq_HepG2_Human0.92385535
177STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92115000
178CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91596733
179ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91566802
180CLOCK_20551151_ChIP-Seq_293T_Human0.90979249
181ATF3_27146783_Chip-Seq_COLON_Human0.90578304
182ZNF263_19887448_ChIP-Seq_K562_Human0.89815545
183* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89603163
184SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89125235
185BCL6_27268052_Chip-Seq_Bcells_Human0.88741749
186GATA2_19941826_ChIP-Seq_K562_Human0.88710332
187EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88255705
188SMAD3_21741376_ChIP-Seq_HESCs_Human0.83973859
189MYC_27129775_Chip-Seq_CORNEA_Mouse0.83892879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.51216224
2MP0002132_abnormal_respiratory_system5.39272534
3MP0003718_maternal_effect5.19353187
4MP0004043_abnormal_pH_regulation4.26326416
5MP0008877_abnormal_DNA_methylation4.19602834
6MP0009780_abnormal_chondrocyte_physiolo3.95044682
7MP0001984_abnormal_olfaction3.61909171
8MP0003646_muscle_fatigue3.50043921
9MP0008057_abnormal_DNA_replication3.48058912
10MP0002277_abnormal_respiratory_mucosa3.47073941
11MP0002653_abnormal_ependyma_morphology3.46167671
12MP0000566_synostosis3.45774159
13MP0005623_abnormal_meninges_morphology3.38973578
14MP0008789_abnormal_olfactory_epithelium3.27830358
15MP0003693_abnormal_embryo_hatching2.92999033
16MP0010234_abnormal_vibrissa_follicle2.82219259
17MP0010094_abnormal_chromosome_stability2.81736810
18MP0006072_abnormal_retinal_apoptosis2.69405408
19MP0000579_abnormal_nail_morphology2.60086824
20MP0004233_abnormal_muscle_weight2.57393526
21MP0004957_abnormal_blastocyst_morpholog2.54250330
22MP0010030_abnormal_orbit_morphology2.42531085
23MP0003283_abnormal_digestive_organ2.38094143
24MP0005395_other_phenotype2.35489070
25MP0003878_abnormal_ear_physiology2.34941209
26MP0005377_hearing/vestibular/ear_phenot2.34941209
27MP0005451_abnormal_body_composition2.25814801
28MP0005171_absent_coat_pigmentation2.25398916
29MP0010678_abnormal_skin_adnexa2.20364124
30MP0000383_abnormal_hair_follicle2.20108822
31MP0005646_abnormal_pituitary_gland2.19960182
32MP0003699_abnormal_female_reproductive2.17370519
33MP0003890_abnormal_embryonic-extraembry2.14703971
34MP0005499_abnormal_olfactory_system2.12384178
35MP0005394_taste/olfaction_phenotype2.12384178
36MP0004019_abnormal_vitamin_homeostasis2.09699059
37MP0005083_abnormal_biliary_tract2.07490511
38MP0009278_abnormal_bone_marrow2.05876316
39MP0003111_abnormal_nucleus_morphology2.03008471
40MP0002877_abnormal_melanocyte_morpholog1.98870709
41MP0002249_abnormal_larynx_morphology1.96384485
42MP0003077_abnormal_cell_cycle1.95212158
43MP0003656_abnormal_erythrocyte_physiolo1.95190885
44MP0002168_other_aberrant_phenotype1.93836176
45MP0004264_abnormal_extraembryonic_tissu1.93469584
46MP0000462_abnormal_digestive_system1.92378733
47MP0001119_abnormal_female_reproductive1.89518802
48MP0008932_abnormal_embryonic_tissue1.86277844
49MP0001346_abnormal_lacrimal_gland1.83571456
50MP0001929_abnormal_gametogenesis1.82749109
51MP0008995_early_reproductive_senescence1.81597282
52MP0001765_abnormal_ion_homeostasis1.78721615
53MP0009379_abnormal_foot_pigmentation1.76022548
54MP0002160_abnormal_reproductive_system1.74673317
55MP0000678_abnormal_parathyroid_gland1.73900188
56MP0003119_abnormal_digestive_system1.71053849
57MP0000653_abnormal_sex_gland1.70036350
58MP0000639_abnormal_adrenal_gland1.65881186
59MP0002282_abnormal_trachea_morphology1.56578787
60MP0005220_abnormal_exocrine_pancreas1.56469140
61MP0002210_abnormal_sex_determination1.56097242
62MP0006292_abnormal_olfactory_placode1.49584344
63MP0003786_premature_aging1.49510400
64MP0002084_abnormal_developmental_patter1.48316325
65MP0002085_abnormal_embryonic_tissue1.48306072
66MP0002909_abnormal_adrenal_gland1.48283520
67MP0002009_preneoplasia1.47024521
68MP0003453_abnormal_keratinocyte_physiol1.41561368
69MP0008058_abnormal_DNA_repair1.40326989
70MP0005165_increased_susceptibility_to1.39028110
71MP0000465_gastrointestinal_hemorrhage1.35391445
72MP0010155_abnormal_intestine_physiology1.34682308
73MP0001697_abnormal_embryo_size1.33497965
74MP0001145_abnormal_male_reproductive1.29645993
75MP0005248_abnormal_Harderian_gland1.26930673
76MP0005636_abnormal_mineral_homeostasis1.26790942
77MP0002269_muscular_atrophy1.26345627
78MP0002161_abnormal_fertility/fecundity1.23849445
79MP0002796_impaired_skin_barrier1.20564166
80MP0000613_abnormal_salivary_gland1.19935505
81MP0002098_abnormal_vibrissa_morphology1.19611407
82MP0001849_ear_inflammation1.17417615
83MP0001730_embryonic_growth_arrest1.16508369
84MP0010386_abnormal_urinary_bladder1.09812356
85MP0000467_abnormal_esophagus_morphology1.08544971
86MP0003123_paternal_imprinting1.08405390
87MP0001672_abnormal_embryogenesis/_devel1.06886079
88MP0005380_embryogenesis_phenotype1.06886079
89MP0000350_abnormal_cell_proliferation1.06830703
90MP0001944_abnormal_pancreas_morphology1.04923446
91MP0003315_abnormal_perineum_morphology1.03660970
92MP0002233_abnormal_nose_morphology1.03033414
93MP0003303_peritoneal_inflammation1.01100073
94MP0000681_abnormal_thyroid_gland0.98770953
95MP0002693_abnormal_pancreas_physiology0.97095451
96MP0003755_abnormal_palate_morphology0.96986530
97MP0002086_abnormal_extraembryonic_tissu0.95586428
98MP0002932_abnormal_joint_morphology0.95260498
99MP0002734_abnormal_mechanical_nocicepti0.93497887
100MP0005645_abnormal_hypothalamus_physiol0.93312006
101MP0000858_altered_metastatic_potential0.92988052
102MP0000470_abnormal_stomach_morphology0.91633714
103MP0009643_abnormal_urine_homeostasis0.90631514
104MP0005257_abnormal_intraocular_pressure0.90628850
105MP0005379_endocrine/exocrine_gland_phen0.90441506
106MP0004133_heterotaxia0.90161349
107MP0005409_darkened_coat_color0.90020413
108MP0002163_abnormal_gland_morphology0.89129060
109MP0000490_abnormal_crypts_of0.88739385
110MP0005164_abnormal_response_to0.88270696
111MP0003806_abnormal_nucleotide_metabolis0.87567185
112MP0003937_abnormal_limbs/digits/tail_de0.85467444
113MP0005187_abnormal_penis_morphology0.84894197
114MP0005076_abnormal_cell_differentiation0.84515269
115MP0002295_abnormal_pulmonary_circulatio0.83819504
116MP0001919_abnormal_reproductive_system0.83679273
117MP0001502_abnormal_circadian_rhythm0.83335500
118MP0002116_abnormal_craniofacial_bone0.83298929
119MP0003941_abnormal_skin_development0.82435606
120MP0003935_abnormal_craniofacial_develop0.82061586
121MP0002019_abnormal_tumor_incidence0.81824745
122MP0003787_abnormal_imprinting0.80512604
123MP0002136_abnormal_kidney_physiology0.80205815
124MP0000015_abnormal_ear_pigmentation0.79945559
125MP0002876_abnormal_thyroid_physiology0.79566046
126MP0001340_abnormal_eyelid_morphology0.78916343
127MP0002080_prenatal_lethality0.77938887
128MP0002111_abnormal_tail_morphology0.76318246
129MP0005408_hypopigmentation0.74688968
130MP0003075_altered_response_to0.72807760
131MP0005058_abnormal_lysosome_morphology0.72513253
132MP0002735_abnormal_chemical_nociception0.72373937
133MP0004883_abnormal_blood_vessel0.71888514
134MP0005397_hematopoietic_system_phenotyp0.71194873
135MP0001545_abnormal_hematopoietic_system0.71194873
136MP0005389_reproductive_system_phenotype0.69461438
137MP0002332_abnormal_exercise_endurance0.66864476
138MP0005023_abnormal_wound_healing0.65160950
139MP0009765_abnormal_xenobiotic_induced0.64345473
140MP0001485_abnormal_pinna_reflex0.64184325
141MP0002102_abnormal_ear_morphology0.62710865
142MP0002114_abnormal_axial_skeleton0.61487722
143MP0001188_hyperpigmentation0.61153434
144MP0005310_abnormal_salivary_gland0.60547519
145MP0001186_pigmentation_phenotype0.59843461
146MP0002405_respiratory_system_inflammati0.59836278
147MP0002638_abnormal_pupillary_reflex0.59691211
148MP0003866_abnormal_defecation0.59304074
149MP0004185_abnormal_adipocyte_glucose0.58248064
150MP0004197_abnormal_fetal_growth/weight/0.58171364
151MP0005365_abnormal_bile_salt0.57921545
152MP0003984_embryonic_growth_retardation0.57667539
153MP0004782_abnormal_surfactant_physiolog0.57517836
154MP0003698_abnormal_male_reproductive0.56916707
155MP0006036_abnormal_mitochondrial_physio0.56794342
156MP0003942_abnormal_urinary_system0.56260726
157MP0005501_abnormal_skin_physiology0.55840652
158MP0000631_abnormal_neuroendocrine_gland0.55690812
159MP0001270_distended_abdomen0.55598581
160MP0009703_decreased_birth_body0.55478212
161MP0005085_abnormal_gallbladder_physiolo0.55234046
162MP0009763_increased_sensitivity_to0.54911461
163MP0001664_abnormal_digestion0.53526913
164MP0001293_anophthalmia0.52721084
165MP0003191_abnormal_cellular_cholesterol0.52074034
166MP0002896_abnormal_bone_mineralization0.50592393
167MP0000762_abnormal_tongue_morphology0.50450713
168MP0001216_abnormal_epidermal_layer0.49207088
169MP0001663_abnormal_digestive_system0.48440654
170MP0003566_abnormal_cell_adhesion0.48185052
171MP0005388_respiratory_system_phenotype0.45838296
172MP0002133_abnormal_respiratory_system0.45838296
173MP0010771_integument_phenotype0.45094524
174MP0006082_CNS_inflammation0.44862063
175MP0002139_abnormal_hepatobiliary_system0.43879523
176MP0001666_abnormal_nutrient_absorption0.43647421
177MP0002822_catalepsy0.43633082
178MP0001299_abnormal_eye_distance/0.43259570
179MP0005166_decreased_susceptibility_to0.42736716

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.94338604
2Bronchiectasis (HP:0002110)7.53455854
3Nasal polyposis (HP:0100582)7.02485830
4Abnormality of the nasal mucosa (HP:0000433)5.84669589
5Rib fusion (HP:0000902)4.99120829
6Facial hemangioma (HP:0000329)4.93989142
7Bronchitis (HP:0012387)4.39913266
8Recurrent sinusitis (HP:0011108)4.37945827
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.29271913
10Infertility (HP:0000789)4.17086445
11Chronic sinusitis (HP:0011109)4.13634882
12Recurrent otitis media (HP:0000403)3.98656872
13Premature ovarian failure (HP:0008209)3.58855550
14Occipital encephalocele (HP:0002085)3.49070556
15Concave nail (HP:0001598)3.48729781
16Tongue fasciculations (HP:0001308)3.44555342
17Patellar aplasia (HP:0006443)3.42039791
18Turricephaly (HP:0000262)3.28923581
19Intestinal atresia (HP:0011100)3.26691808
20Abnormality of the labia minora (HP:0012880)3.23672676
21Absent radius (HP:0003974)3.22382367
22Rectovaginal fistula (HP:0000143)3.19553587
23Rectal fistula (HP:0100590)3.19553587
24Annular pancreas (HP:0001734)3.19460104
25Hyperactive renin-angiotensin system (HP:0000841)3.19133586
26Pancreatic fibrosis (HP:0100732)3.14415192
27Chronic otitis media (HP:0000389)3.11761451
28Aplasia/Hypoplasia of the patella (HP:0006498)3.11281743
29Absent forearm bone (HP:0003953)3.09954701
30Aplasia involving forearm bones (HP:0009822)3.09954701
31Pustule (HP:0200039)3.09930595
32True hermaphroditism (HP:0010459)3.09587988
33Poikiloderma (HP:0001029)3.08414802
34Muscle fibrillation (HP:0010546)3.08215678
35Breast hypoplasia (HP:0003187)3.03521843
36Dysautonomia (HP:0002459)2.95964725
37Shawl scrotum (HP:0000049)2.93593351
38Intestinal fistula (HP:0100819)2.89641948
39Vaginal fistula (HP:0004320)2.82158530
40Large for gestational age (HP:0001520)2.80066411
41Capillary hemangiomas (HP:0005306)2.79327251
42Short humerus (HP:0005792)2.75634120
43Flat capital femoral epiphysis (HP:0003370)2.75108091
44Insulin-resistant diabetes mellitus (HP:0000831)2.74921694
45Orthostatic hypotension (HP:0001278)2.69640125
46Growth hormone excess (HP:0000845)2.66949773
47Popliteal pterygium (HP:0009756)2.65547724
48Ulnar bowing (HP:0003031)2.63275486
49Cystic liver disease (HP:0006706)2.63136443
50Aplasia/hypoplasia of the humerus (HP:0006507)2.62857709
51Increased IgM level (HP:0003496)2.62620882
52Pancreatic islet-cell hyperplasia (HP:0004510)2.60749851
53Anteriorly placed anus (HP:0001545)2.57878999
54Secondary amenorrhea (HP:0000869)2.57554035
55Abnormality of polysaccharide metabolism (HP:0011012)2.56458705
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56458705
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56458705
58Alopecia of scalp (HP:0002293)2.54263727
59Hyperglycemia (HP:0003074)2.49943215
60Choanal stenosis (HP:0000452)2.49015209
61Molar tooth sign on MRI (HP:0002419)2.48728107
62Abnormality of midbrain morphology (HP:0002418)2.48728107
63Pancreatic cysts (HP:0001737)2.46801701
64Urinary glycosaminoglycan excretion (HP:0003541)2.46592999
65Mucopolysacchariduria (HP:0008155)2.46592999
66Abnormality of the fovea (HP:0000493)2.43388631
67Nephronophthisis (HP:0000090)2.41307581
68Birth length less than 3rd percentile (HP:0003561)2.40950534
69Hypochromic microcytic anemia (HP:0004840)2.40518732
70Hypogonadotrophic hypogonadism (HP:0000044)2.37877181
71Hypoplasia of the fovea (HP:0007750)2.36990922
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.36990922
73Abnormal hemoglobin (HP:0011902)2.35650344
74Coronal craniosynostosis (HP:0004440)2.27956883
75Abnormality of male internal genitalia (HP:0000022)2.26395755
76Amniotic constriction ring (HP:0009775)2.24604465
77Abnormality of placental membranes (HP:0011409)2.24604465
78Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23940503
79Postaxial foot polydactyly (HP:0001830)2.23421735
80Abnormality of the aortic arch (HP:0012303)2.21359487
81Abnormality of the pancreatic islet cells (HP:0006476)2.20339419
82Abnormality of endocrine pancreas physiology (HP:0012093)2.20339419
83Dysostosis multiplex (HP:0000943)2.19910504
84Muscle fiber atrophy (HP:0100295)2.19522931
85Type 2 muscle fiber atrophy (HP:0003554)2.17846713
86Chronic hepatic failure (HP:0100626)2.17799778
87Aplasia of the musculature (HP:0100854)2.17330612
88Cystic hygroma (HP:0000476)2.16447253
89Fetal akinesia sequence (HP:0001989)2.15602900
90Cortical dysplasia (HP:0002539)2.14200642
91Alacrima (HP:0000522)2.09929540
92Vertebral hypoplasia (HP:0008417)2.09679397
93Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.09679397
94Congenital hip dislocation (HP:0001374)2.07378639
95Bell-shaped thorax (HP:0001591)2.06840835
96Chronic bronchitis (HP:0004469)2.04843366
97Broad alveolar ridges (HP:0000187)2.03729457
98Breast aplasia (HP:0100783)2.00646263
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7179255
100Abnormal respiratory epithelium morphology (HP:0012253)11.3382946
101Abnormal respiratory motile cilium morphology (HP:0005938)11.3382946
102Abnormal respiratory motile cilium physiology (HP:0012261)11.1191146
103Absent/shortened dynein arms (HP:0200106)10.9118285
104Dynein arm defect of respiratory motile cilia (HP:0012255)10.9118285
105Abnormal ciliary motility (HP:0012262)10.7808296
106Rhinitis (HP:0012384)10.3360532
107Pulmonary fibrosis (HP:0002206)1.99359211
108Tubulointerstitial nephritis (HP:0001970)1.99246672
109Exocrine pancreatic insufficiency (HP:0001738)1.98767739
110Adrenal hypoplasia (HP:0000835)1.95183506
111Split hand (HP:0001171)1.94659900
112Renal salt wasting (HP:0000127)1.94550607
113Squamous cell carcinoma (HP:0002860)1.91559656
114Absent frontal sinuses (HP:0002688)1.91340239
115Aplasia/Hypoplasia of the breasts (HP:0010311)1.90874625
116Absent thumb (HP:0009777)1.90539709
117Progressive neurologic deterioration (HP:0002344)1.89551426
118Premature graying of hair (HP:0002216)1.88952304
119Delayed puberty (HP:0000823)1.88349058
120Spinal muscular atrophy (HP:0007269)1.86556248
121Abnormality of the renal medulla (HP:0100957)1.85688786
122Congenital hepatic fibrosis (HP:0002612)1.84475206
123Aplasia/Hypoplasia of the ulna (HP:0006495)1.84362476
124Anencephaly (HP:0002323)1.83752970
125Exertional dyspnea (HP:0002875)1.82478052
126Thin ribs (HP:0000883)1.82362848
127Short thumb (HP:0009778)1.82303061
128Atelectasis (HP:0100750)1.82277383
129Absent hand (HP:0004050)1.80665832
130Hypercortisolism (HP:0001578)1.79759780
131Polycythemia (HP:0001901)1.79573005
132Recurrent bronchitis (HP:0002837)1.79281202
133Joint stiffness (HP:0001387)1.77798537
134Volvulus (HP:0002580)1.77582877
135Decreased circulating renin level (HP:0003351)1.77428873
136Male pseudohermaphroditism (HP:0000037)1.77407089
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.77212411
138Generalized hyperpigmentation (HP:0007440)1.77070592
139Asplenia (HP:0001746)1.73636990
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.71398211
141Hyperkalemia (HP:0002153)1.66606039
142Furrowed tongue (HP:0000221)1.60259172
143Medial flaring of the eyebrow (HP:0010747)1.58947401
144Nephropathy (HP:0000112)1.58594487
145Abnormality of the distal phalanges of the toes (HP:0010182)1.55707188
146Oculomotor apraxia (HP:0000657)1.55444994
147Hyperaldosteronism (HP:0000859)1.53326536
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.49942269
149Sclerocornea (HP:0000647)1.49294744
150Congenital primary aphakia (HP:0007707)1.47905728
151Tubular atrophy (HP:0000092)1.45378076
152Gait imbalance (HP:0002141)1.44046549
153Abnormality of chloride homeostasis (HP:0011422)1.40594897
154Hand muscle atrophy (HP:0009130)1.39481595
155Abnormality of renin-angiotensin system (HP:0000847)1.37602177
156Postaxial hand polydactyly (HP:0001162)1.36110139
157Short nail (HP:0001799)1.32614443
158Abnormality of the dental root (HP:0006486)1.30127090
159Taurodontia (HP:0000679)1.30127090
160Abnormality of permanent molar morphology (HP:0011071)1.30127090
161Bifid scrotum (HP:0000048)1.29402124
162Hyponatremia (HP:0002902)1.27168026
163Nephrogenic diabetes insipidus (HP:0009806)1.26691491
164Median cleft lip (HP:0000161)1.25814627
165Obstructive sleep apnea (HP:0002870)1.25695157
166Glucose intolerance (HP:0000833)1.24843847
167Short thorax (HP:0010306)1.23943301
168Hypokalemic alkalosis (HP:0001949)1.20851069
169Abnormality of the frontal sinuses (HP:0002687)1.20676065
170Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.19307049
171Abnormality of molar morphology (HP:0011070)1.19287453
172Abnormality of molar (HP:0011077)1.19287453
173Preaxial hand polydactyly (HP:0001177)1.18058050
174Lip pit (HP:0100267)1.17037617
175Flat acetabular roof (HP:0003180)1.15573995
176Abnormality of the dental pulp (HP:0006479)1.14169403
177Cone-rod dystrophy (HP:0000548)1.12284553
178Muscle fiber splitting (HP:0003555)1.10068942
179Short femoral neck (HP:0100864)1.08351934
180Stridor (HP:0010307)1.08087888
181Carpal bone hypoplasia (HP:0001498)1.06362002
182Distal lower limb muscle weakness (HP:0009053)1.05945501
183Tubulointerstitial abnormality (HP:0001969)1.05540043
184Spinal cord compression (HP:0002176)1.04608957
185Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.04470201
186Abnormality of monocarboxylic acid metabolism (HP:0010996)1.04373035
187Stage 5 chronic kidney disease (HP:0003774)1.03644733
188Decreased central vision (HP:0007663)1.02795394
189Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.02502884
190Distal upper limb amyotrophy (HP:0007149)1.02178157
191Upper limb amyotrophy (HP:0009129)1.02178157
192Diaphragmatic weakness (HP:0009113)1.00843130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K66.08557284
2MST45.63028413
3MAPK155.00880344
4ICK3.56343910
5DDR23.29749469
6LATS23.06768529
7PINK12.92423137
8SMG12.70329011
9LATS12.58763130
10NME12.53141269
11BMPR22.48705196
12MOS2.36793960
13ERBB42.28557391
14PRKD22.19286987
15TYRO32.15889544
16STK38L2.06167782
17STK242.03420428
18TAOK31.98502567
19MAP3K111.95571413
20PRKD31.95393255
21CDK81.86871710
22MAP3K31.84447761
23KSR21.81954306
24MAP3K91.74747137
25TTK1.72190600
26FGR1.69999548
27MATK1.60330075
28MST1R1.59250493
29BRAF1.59192026
30CHEK21.54950824
31RAF11.41523549
32AKT31.39382040
33HIPK21.38817519
34DAPK11.37498080
35PLK11.30010084
36UHMK11.28919697
37LRRK21.27929901
38DYRK21.27479870
39DYRK1B1.27255636
40PTK2B1.25334391
41EPHB11.24286649
42ARAF1.21003108
43CDK71.20652622
44PLK41.18071145
45PDGFRA1.17926591
46TAOK11.17560205
47CSK1.10975692
48BCR1.09921090
49NEK61.08175363
50TRPM71.07373709
51MUSK1.06609624
52STK31.05463308
53BUB11.05230125
54TESK11.03290943
55PIM21.01451445
56TLK10.98606237
57MAPK110.96644774
58BMX0.94810051
59MAPKAPK30.94467362
60DYRK30.92743324
61MARK20.89820169
62NEK20.88568899
63MAP3K70.88362073
64TBK10.86260183
65MELK0.85282094
66MAP3K120.84129732
67RIPK40.83476931
68PRKAA10.80207711
69AURKA0.80029408
70CSNK1G10.78324947
71PIM10.76394838
72PNCK0.74919540
73YES10.73268733
74RIPK10.71354824
75CDC70.71083151
76CDC42BPA0.69092532
77PBK0.68369474
78STK160.66337871
79EPHA30.66131225
80PAK60.64622605
81STK380.64260641
82STK100.63346725
83RPS6KB20.62407558
84PAK40.59624155
85ERBB30.58364743
86GRK60.58167480
87ERBB20.58073367
88PASK0.57942818
89CAMKK10.54610321
90GSK3A0.52802018
91CAMK2G0.52556887
92AURKB0.49514054
93WNK30.48931122
94EPHA20.47532607
95RPS6KC10.47128256
96RPS6KL10.47128256
97RPS6KA10.46712831
98ACVR1B0.44543316
99PRKCD0.43974864
100BRSK20.43087834
101MET0.42802822
102MAP3K20.41633641
103MAP3K80.40836901
104MTOR0.40524115
105CDK90.40152721
106RPS6KA60.40043130
107CDK60.39931096
108MAP3K130.38806851
109INSRR0.37763258
110PDPK10.37493415
111PTK60.36551951
112PRKCQ0.35993371
113PRKAA20.35654123
114CDK20.35437781
115SGK10.35201395
116FER0.33587756
117PTK20.33422524
118PRPF4B0.32792347
119ATM0.31390212
120CSNK1G30.31083030
121MAP3K40.30522071
122BRSK10.29333386
123EEF2K0.28500522
124CAMK2A0.27834928
125FGFR30.27786764
126PHKG20.27251976
127PHKG10.27251976
128ROCK20.27073349
129MAP2K20.26761069
130TRIB30.26217500
131CDK10.25837627
132CSNK1G20.25758268
133AKT20.25625651
134DMPK0.25279357
135PRKCI0.25002219
136CHEK10.24799202
137MAPK10.24632016
138LMTK20.24447592
139NLK0.24323626
140ATR0.23843934
141MAPK30.23576359
142MAPK130.22601006
143ILK0.22361039
144MAPKAPK50.22045285
145MYLK0.20419812
146MAP3K10.20354200
147ZAP700.20173836
148PAK10.20152737
149RPS6KA20.19005740
150IRAK10.16788109
151TSSK60.16583723
152ABL10.15948721
153PRKCA0.14283889
154ROCK10.14271071
155PRKACA0.14211339
156ABL20.13870812
157SRC0.13643638
158FYN0.12412927
159MAP2K40.11483871
160EGFR0.10779934
161CCNB10.10047107
162RET0.07832273
163TYK20.07798590

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.88299322
2Phenylalanine metabolism_Homo sapiens_hsa003605.39283866
3Histidine metabolism_Homo sapiens_hsa003404.86742052
4Chemical carcinogenesis_Homo sapiens_hsa052044.57539577
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.33856637
6Maturity onset diabetes of the young_Homo sapiens_hsa049504.32544881
7Tyrosine metabolism_Homo sapiens_hsa003504.14017215
8Base excision repair_Homo sapiens_hsa034103.75440655
9Circadian rhythm_Homo sapiens_hsa047103.50355382
10Fatty acid biosynthesis_Homo sapiens_hsa000613.23373253
11beta-Alanine metabolism_Homo sapiens_hsa004103.15479852
12Mismatch repair_Homo sapiens_hsa034303.15063933
13Glutathione metabolism_Homo sapiens_hsa004802.97355827
14Huntingtons disease_Homo sapiens_hsa050162.83060434
15Cell cycle_Homo sapiens_hsa041102.72990340
16Caffeine metabolism_Homo sapiens_hsa002322.39223574
17Basal transcription factors_Homo sapiens_hsa030222.37656628
18Retinol metabolism_Homo sapiens_hsa008302.36915594
19RNA transport_Homo sapiens_hsa030132.25429493
20Vitamin B6 metabolism_Homo sapiens_hsa007502.25159575
21DNA replication_Homo sapiens_hsa030302.12868520
22Folate biosynthesis_Homo sapiens_hsa007902.10918274
23Oocyte meiosis_Homo sapiens_hsa041142.09609265
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08912450
25Homologous recombination_Homo sapiens_hsa034402.05750355
26Fanconi anemia pathway_Homo sapiens_hsa034602.02824987
27RNA degradation_Homo sapiens_hsa030182.00987781
28Ovarian steroidogenesis_Homo sapiens_hsa049131.96605339
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.95911690
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.92890979
31mRNA surveillance pathway_Homo sapiens_hsa030151.90840605
32mTOR signaling pathway_Homo sapiens_hsa041501.88900800
33Nucleotide excision repair_Homo sapiens_hsa034201.82965645
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75895120
35Sphingolipid metabolism_Homo sapiens_hsa006001.74894423
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74583006
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71634674
38Protein export_Homo sapiens_hsa030601.71224750
39RNA polymerase_Homo sapiens_hsa030201.62607385
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61148098
41Hippo signaling pathway_Homo sapiens_hsa043901.58323000
42Arginine and proline metabolism_Homo sapiens_hsa003301.57239183
43TGF-beta signaling pathway_Homo sapiens_hsa043501.51633596
44p53 signaling pathway_Homo sapiens_hsa041151.44462248
45Linoleic acid metabolism_Homo sapiens_hsa005911.43463557
46Notch signaling pathway_Homo sapiens_hsa043301.40381763
47Bladder cancer_Homo sapiens_hsa052191.37272042
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.35474494
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35128790
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32907440
51Fatty acid degradation_Homo sapiens_hsa000711.32007623
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28875099
53Dorso-ventral axis formation_Homo sapiens_hsa043201.28763514
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.28738558
55Hedgehog signaling pathway_Homo sapiens_hsa043401.28641109
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23688895
57Adherens junction_Homo sapiens_hsa045201.18603765
58ABC transporters_Homo sapiens_hsa020101.12135926
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11728834
60Peroxisome_Homo sapiens_hsa041461.08939061
61GnRH signaling pathway_Homo sapiens_hsa049121.05794515
62Colorectal cancer_Homo sapiens_hsa052101.02777059
63Choline metabolism in cancer_Homo sapiens_hsa052310.99319122
64Salivary secretion_Homo sapiens_hsa049700.95491230
65Pancreatic cancer_Homo sapiens_hsa052120.90471153
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.89323705
67VEGF signaling pathway_Homo sapiens_hsa043700.88753413
68Starch and sucrose metabolism_Homo sapiens_hsa005000.85484485
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84896276
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.84372662
71Spliceosome_Homo sapiens_hsa030400.81522554
72Hepatitis C_Homo sapiens_hsa051600.80198925
73Wnt signaling pathway_Homo sapiens_hsa043100.79187030
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.79096507
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.78494400
76Prolactin signaling pathway_Homo sapiens_hsa049170.78165846
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77587897
78Regulation of autophagy_Homo sapiens_hsa041400.77079583
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77034168
80MicroRNAs in cancer_Homo sapiens_hsa052060.74837380
81Sulfur relay system_Homo sapiens_hsa041220.72758330
82Ether lipid metabolism_Homo sapiens_hsa005650.72153612
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71091336
84Fatty acid metabolism_Homo sapiens_hsa012120.70239137
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.65726198
86Lysine degradation_Homo sapiens_hsa003100.63018847
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62490157
88Vibrio cholerae infection_Homo sapiens_hsa051100.61990267
89Collecting duct acid secretion_Homo sapiens_hsa049660.60602551
90Biosynthesis of amino acids_Homo sapiens_hsa012300.59218701
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58516354
92Long-term depression_Homo sapiens_hsa047300.57149626
93Thyroid cancer_Homo sapiens_hsa052160.55769748
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.54324650
95Shigellosis_Homo sapiens_hsa051310.52384482
96Insulin signaling pathway_Homo sapiens_hsa049100.52124916
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51963629
98Pyrimidine metabolism_Homo sapiens_hsa002400.51223667
99Insulin secretion_Homo sapiens_hsa049110.48324051
100Gap junction_Homo sapiens_hsa045400.48156841
101Estrogen signaling pathway_Homo sapiens_hsa049150.47525300
102Tight junction_Homo sapiens_hsa045300.46814967
103Endometrial cancer_Homo sapiens_hsa052130.46208186
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46153306
105Amoebiasis_Homo sapiens_hsa051460.45722664
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44335158
107ErbB signaling pathway_Homo sapiens_hsa040120.42670341
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42564626
109N-Glycan biosynthesis_Homo sapiens_hsa005100.42516107
110Taste transduction_Homo sapiens_hsa047420.42268927
111Hematopoietic cell lineage_Homo sapiens_hsa046400.40338329
112Other glycan degradation_Homo sapiens_hsa005110.40060428
113Non-homologous end-joining_Homo sapiens_hsa034500.39054312
114PPAR signaling pathway_Homo sapiens_hsa033200.37870123
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35418377
116Lysosome_Homo sapiens_hsa041420.35145998
117Glucagon signaling pathway_Homo sapiens_hsa049220.34828197
118Olfactory transduction_Homo sapiens_hsa047400.34120595
119Metabolic pathways_Homo sapiens_hsa011000.33639317
120AMPK signaling pathway_Homo sapiens_hsa041520.32196826
121Pyruvate metabolism_Homo sapiens_hsa006200.31561627
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31353523
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30868403
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30821366
125Complement and coagulation cascades_Homo sapiens_hsa046100.30246480
126Galactose metabolism_Homo sapiens_hsa000520.29313576
127Chronic myeloid leukemia_Homo sapiens_hsa052200.28933826
128MAPK signaling pathway_Homo sapiens_hsa040100.28717424
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27773206
130Vitamin digestion and absorption_Homo sapiens_hsa049770.27009049
131Ras signaling pathway_Homo sapiens_hsa040140.26154900
132Purine metabolism_Homo sapiens_hsa002300.25294814
133FoxO signaling pathway_Homo sapiens_hsa040680.25211242
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24805263
135Prostate cancer_Homo sapiens_hsa052150.23946072
136Fructose and mannose metabolism_Homo sapiens_hsa000510.23870989
137Arginine biosynthesis_Homo sapiens_hsa002200.23397837
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.23261412
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22790722
140Basal cell carcinoma_Homo sapiens_hsa052170.20823702
141Arachidonic acid metabolism_Homo sapiens_hsa005900.20313593
142Insulin resistance_Homo sapiens_hsa049310.17140862
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16727960
144cAMP signaling pathway_Homo sapiens_hsa040240.16477192
145Renal cell carcinoma_Homo sapiens_hsa052110.16126594
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15860995
147Endocytosis_Homo sapiens_hsa041440.15383911
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15029188
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14066005
150Amphetamine addiction_Homo sapiens_hsa050310.14065210
1512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13848909
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.12511274
153Glycerolipid metabolism_Homo sapiens_hsa005610.11323581
154Cocaine addiction_Homo sapiens_hsa050300.10953223
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.09790040
156Pancreatic secretion_Homo sapiens_hsa049720.09569092
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09552697
158Type I diabetes mellitus_Homo sapiens_hsa049400.09487480
159Phagosome_Homo sapiens_hsa041450.08338872
160RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07052959
161Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.05785637
162Bile secretion_Homo sapiens_hsa049760.05104635
163Melanogenesis_Homo sapiens_hsa049160.04319660
164Serotonergic synapse_Homo sapiens_hsa047260.02371776
165Apoptosis_Homo sapiens_hsa042100.02166775
166Axon guidance_Homo sapiens_hsa043600.01845431
167Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.01408654
168Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.01106663
169Calcium signaling pathway_Homo sapiens_hsa040200.00701838
170Allograft rejection_Homo sapiens_hsa053300.00132939

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