CD177

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of metal ion (GO:0051238)8.78444188
2killing of cells in other organism involved in symbiotic interaction (GO:0051883)8.62642947
3disruption of cells of other organism involved in symbiotic interaction (GO:0051818)8.62642947
4response to fungus (GO:0009620)7.96097088
5response to peptidoglycan (GO:0032494)7.88769129
6respiratory burst (GO:0045730)6.82833991
7cellular extravasation (GO:0045123)6.63767916
8neutrophil activation involved in immune response (GO:0002283)6.53076275
9killing of cells of other organism (GO:0031640)6.52108600
10disruption of cells of other organism (GO:0044364)6.52108600
11chronic inflammatory response (GO:0002544)6.45606973
12neutrophil mediated immunity (GO:0002446)6.19764025
13neutrophil activation (GO:0042119)5.79094261
14production of molecular mediator involved in inflammatory response (GO:0002532)5.76605571
15macrophage differentiation (GO:0030225)5.66898129
16detection of bacterium (GO:0016045)5.64769350
17negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.59268230
18neutrophil chemotaxis (GO:0030593)5.50983145
19neutrophil migration (GO:1990266)5.36483255
20detection of other organism (GO:0098543)5.29977055
21granulocyte activation (GO:0036230)5.22102266
22superoxide anion generation (GO:0042554)5.13439483
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.11915333
24negative regulation of cell killing (GO:0031342)5.11915333
25regulation of myeloid leukocyte mediated immunity (GO:0002886)5.11729237
26hydrogen peroxide biosynthetic process (GO:0050665)5.09807346
27positive regulation of mast cell activation (GO:0033005)5.06992404
28phagosome maturation (GO:0090382)4.95286918
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.92904145
30response to host immune response (GO:0052572)4.92904145
31regulation of leukocyte degranulation (GO:0043300)4.88035740
32granulocyte migration (GO:0097530)4.81331716
33reactive oxygen species biosynthetic process (GO:1903409)4.68504230
34innate immune response in mucosa (GO:0002227)4.68377227
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67390939
36myeloid leukocyte mediated immunity (GO:0002444)4.65185579
37granulocyte chemotaxis (GO:0071621)4.64078205
38mucosal immune response (GO:0002385)4.63005243
39mast cell activation (GO:0045576)4.60855190
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.54210778
41response to host (GO:0075136)4.54210778
42response to host defenses (GO:0052200)4.54210778
43antibacterial humoral response (GO:0019731)4.51534959
44regulation of regulated secretory pathway (GO:1903305)4.49751507
45antimicrobial humoral response (GO:0019730)4.46642186
46antigen processing and presentation of endogenous antigen (GO:0019883)4.42563245
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.37714866
48positive regulation of mast cell degranulation (GO:0043306)4.37284967
49positive regulation of mast cell activation involved in immune response (GO:0033008)4.37284967
50organ or tissue specific immune response (GO:0002251)4.37199317
51regulation of mast cell activation (GO:0033003)4.36355229
52pentose-phosphate shunt (GO:0006098)4.33662501
53macrophage activation involved in immune response (GO:0002281)4.31407682
54positive regulation of gamma-delta T cell activation (GO:0046645)4.30272880
55leukocyte cell-cell adhesion (GO:0007159)4.17266711
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.13953004
57regulation of B cell receptor signaling pathway (GO:0050855)4.12066249
58Arp2/3 complex-mediated actin nucleation (GO:0034314)4.10552389
59regulation of mast cell degranulation (GO:0043304)4.10438937
60leukotriene metabolic process (GO:0006691)4.07675861
61leukotriene biosynthetic process (GO:0019370)4.05954048
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99128964
63detection of biotic stimulus (GO:0009595)3.95298664
64regulation of mast cell activation involved in immune response (GO:0033006)3.92220088
65negative regulation of phagocytosis (GO:0050765)3.92070550
66folic acid transport (GO:0015884)3.91334869
67glucose 6-phosphate metabolic process (GO:0051156)3.90578085
68NADPH regeneration (GO:0006740)3.86292043
69positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.85308926
70positive regulation of toll-like receptor signaling pathway (GO:0034123)3.73796751
71negative regulation of lymphocyte mediated immunity (GO:0002707)3.72889291
72defense response to Gram-positive bacterium (GO:0050830)3.71613181
73negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.68329814
74negative regulation of T-helper cell differentiation (GO:0045623)3.68329814
75positive regulation of osteoblast proliferation (GO:0033690)3.65092950
76negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.63326589
77modulation of growth of symbiont involved in interaction with host (GO:0044144)3.63326589
78regulation of growth of symbiont in host (GO:0044126)3.63326589
79negative regulation of growth of symbiont in host (GO:0044130)3.63326589
80cell killing (GO:0001906)3.61221868
81B cell mediated immunity (GO:0019724)3.58811122
82regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.54160370
83myeloid cell activation involved in immune response (GO:0002275)3.51347113
84positive regulation of lamellipodium assembly (GO:0010592)3.50904068
85myeloid leukocyte migration (GO:0097529)3.50076264
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.47761574
87positive regulation of leukocyte degranulation (GO:0043302)3.46482500
88negative regulation of leukocyte mediated immunity (GO:0002704)3.43523880
89regulation of T-helper 2 cell differentiation (GO:0045628)3.42244551
90monocyte chemotaxis (GO:0002548)3.37819517
91adaptation of signaling pathway (GO:0023058)3.36090427
92cytokine secretion (GO:0050663)3.35758631
93defense response to bacterium (GO:0042742)3.35062640
94positive regulation of regulated secretory pathway (GO:1903307)3.28569269
95negative regulation of alpha-beta T cell activation (GO:0046636)3.23331352
96regulation of interferon-beta biosynthetic process (GO:0045357)3.17660767
97detection of molecule of bacterial origin (GO:0032490)3.17032092
98leukocyte degranulation (GO:0043299)3.13347701
99citrulline biosynthetic process (GO:0019240)3.09598871
100leukocyte mediated cytotoxicity (GO:0001909)3.09575340
101actin nucleation (GO:0045010)3.08298610
102regulation of gamma-delta T cell activation (GO:0046643)3.06308918
103macrophage activation (GO:0042116)3.05975130
104type I interferon signaling pathway (GO:0060337)3.05596800
105cellular response to type I interferon (GO:0071357)3.05596800
106positive regulation of interleukin-8 secretion (GO:2000484)3.05329663
107response to zinc ion (GO:0010043)3.05281494
108leukocyte chemotaxis (GO:0030595)3.04543047
109defense response to protozoan (GO:0042832)3.03755149
110microglial cell activation (GO:0001774)3.02291568
111response to type I interferon (GO:0034340)3.01366818
112germinal center formation (GO:0002467)2.97636206
113positive regulation by symbiont of host defense response (GO:0052509)2.97019227
114modulation by symbiont of host defense response (GO:0052031)2.97019227
115modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97019227
116modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97019227
117positive regulation by organism of defense response of other organism involved in symbiotic interact2.97019227
118modulation by symbiont of host immune response (GO:0052553)2.97019227
119response to bacterium (GO:0009617)2.95867588
120myeloid leukocyte activation (GO:0002274)2.95229006
121detection of external biotic stimulus (GO:0098581)2.95174221
122homotypic cell-cell adhesion (GO:0034109)2.93306843
123immunoglobulin mediated immune response (GO:0016064)2.91723734
124tooth mineralization (GO:0034505)2.91369318
125negative regulation of cytokine production involved in immune response (GO:0002719)2.89256589
126dendritic cell migration (GO:0036336)2.89192600
127negative regulation of interleukin-12 production (GO:0032695)2.88460973
128interferon-gamma-mediated signaling pathway (GO:0060333)2.87472037
129negative regulation of innate immune response (GO:0045824)2.85744339
130negative regulation of immunoglobulin mediated immune response (GO:0002890)2.85448153
131negative regulation of B cell mediated immunity (GO:0002713)2.85448153
132cellular response to interleukin-6 (GO:0071354)2.82822046
133negative regulation of interleukin-10 production (GO:0032693)2.82062184
134regulation of toll-like receptor signaling pathway (GO:0034121)2.81732809
135glucose catabolic process (GO:0006007)2.81056991
136response to interleukin-15 (GO:0070672)2.80887866
137positive regulation of inflammatory response (GO:0050729)2.80744337
138positive regulation of lamellipodium organization (GO:1902745)2.80552174
139regulation of natural killer cell differentiation (GO:0032823)2.79997243
140antigen processing and presentation via MHC class Ib (GO:0002475)2.79256992
141leukocyte aggregation (GO:0070486)12.4886118
142leukocyte migration involved in inflammatory response (GO:0002523)12.4386805
143defense response to fungus (GO:0050832)10.6780780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYB_21317192_ChIP-Seq_ERMYB_Mouse4.99883714
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.66618676
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.47456392
4E2F7_22180533_ChIP-Seq_HELA_Human4.16665430
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.68658962
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.64067920
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.60345330
8BRD4_27068464_Chip-Seq_AML-cells_Mouse3.49352024
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40706450
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.30254323
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.27009605
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.16958014
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14299621
14VDR_21846776_ChIP-Seq_THP-1_Human2.87780121
15SPI1_23547873_ChIP-Seq_NB4_Human2.86575828
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64670354
17SCL_19346495_ChIP-Seq_HPC-7_Human2.55382509
18VDR_24763502_ChIP-Seq_THP-1_Human2.41051891
19SPI1_23127762_ChIP-Seq_K562_Human2.26666515
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26101832
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21757478
22UTX_26944678_Chip-Seq_JUKART_Human2.20825409
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.19606369
24ESR1_15608294_ChIP-ChIP_MCF-7_Human2.14181989
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12359163
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09415891
27MAF_26560356_Chip-Seq_TH1_Human2.09142351
28MYB_26560356_Chip-Seq_TH2_Human2.01796084
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95827471
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94753205
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92311057
32TCF7_22412390_ChIP-Seq_EML_Mouse1.90892958
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81845347
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80401981
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.79791644
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73277121
37PU_27001747_Chip-Seq_BMDM_Mouse1.72328221
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71440240
39MYC_22102868_ChIP-Seq_BL_Human1.68234359
40MYB_26560356_Chip-Seq_TH1_Human1.65212619
41VDR_24787735_ChIP-Seq_THP-1_Human1.64882083
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62604433
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60539107
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.59997622
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59265280
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57854533
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53859938
48RUNX_20019798_ChIP-Seq_JUKART_Human1.53327914
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51214334
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50395754
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49331193
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48087828
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.44377527
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41885068
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40887789
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40431529
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34598797
58GATA3_27048872_Chip-Seq_THYMUS_Human1.33904349
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33801754
60KDM2B_26808549_Chip-Seq_DND41_Human1.33051621
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32292058
62GATA1_19941826_ChIP-Seq_K562_Human1.31766603
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29113294
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29110458
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.28710033
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27701694
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27394993
68GATA2_19941826_ChIP-Seq_K562_Human1.25858040
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25141002
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24503596
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22796408
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22637183
73SPI1_20517297_ChIP-Seq_HL60_Human1.17376470
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17317867
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16957472
76GATA3_26560356_Chip-Seq_TH2_Human1.16543466
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15848339
78MAF_26560356_Chip-Seq_TH2_Human1.15297432
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14806787
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13730121
81BCL6_27268052_Chip-Seq_Bcells_Human1.13371597
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12443947
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11666515
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11462124
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10777032
86LXR_22292898_ChIP-Seq_THP-1_Human1.07638290
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07188132
88STAT1_20625510_ChIP-Seq_HELA_Human1.07155159
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06567890
90P68_20966046_ChIP-Seq_HELA_Human1.06341503
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.06040801
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04816492
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.03343993
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03274540
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02583391
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02338877
97DROSHA_22980978_ChIP-Seq_HELA_Human1.02232422
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.01588766
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01535032
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.01460648
101E2F1_20622854_ChIP-Seq_HELA_Human1.00949638
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00717581
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99846325
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99481254
105CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97974350
106BCOR_27268052_Chip-Seq_Bcells_Human0.97076388
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96668627
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96518947
109E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94270470
110SA1_27219007_Chip-Seq_Bcells_Human0.92713426
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92404087
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90448453
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.89491998
114RACK7_27058665_Chip-Seq_MCF-7_Human0.88478230
115AR_21909140_ChIP-Seq_LNCAP_Human0.87987885
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87382355
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86066195
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85861674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.20088311
2MP0003436_decreased_susceptibility_to5.43206411
3MP0009278_abnormal_bone_marrow4.04545049
4MP0009785_altered_susceptibility_to4.02466419
5MP0003183_abnormal_peptide_metabolism3.80897972
6MP0002837_dystrophic_cardiac_calcinosis3.57606651
7MP0002419_abnormal_innate_immunity3.52085440
8MP0001533_abnormal_skeleton_physiology2.80044687
9MP0005167_abnormal_blood-brain_barrier2.70314370
10MP0005025_abnormal_response_to2.66192267
11MP0006082_CNS_inflammation2.63267669
12MP0000343_altered_response_to2.41876246
13MP0003724_increased_susceptibility_to2.27569892
14MP0002405_respiratory_system_inflammati2.20225665
15MP0001851_eye_inflammation2.19184954
16MP0001853_heart_inflammation2.12509441
17MP0003300_gastrointestinal_ulcer2.12031390
18MP0005000_abnormal_immune_tolerance2.11913083
19MP0005464_abnormal_platelet_physiology2.10465275
20MP0005397_hematopoietic_system_phenotyp2.09501306
21MP0001545_abnormal_hematopoietic_system2.09501306
22MP0001819_abnormal_immune_cell2.01073455
23MP0002420_abnormal_adaptive_immunity2.01018402
24MP0003075_altered_response_to1.99730037
25MP0000465_gastrointestinal_hemorrhage1.96292060
26MP0002452_abnormal_antigen_presenting1.94522568
27MP0004883_abnormal_blood_vessel1.93190670
28MP0000685_abnormal_immune_system1.89930059
29MP0002148_abnormal_hypersensitivity_rea1.89711701
30MP0001835_abnormal_antigen_presentation1.88044370
31MP0000858_altered_metastatic_potential1.87458310
32MP0001845_abnormal_inflammatory_respons1.87206315
33MP0001800_abnormal_humoral_immune1.79124410
34MP0009764_decreased_sensitivity_to1.72588603
35MP0004264_abnormal_extraembryonic_tissu1.71431364
36MP0004808_abnormal_hematopoietic_stem1.70962457
37MP0002138_abnormal_hepatobiliary_system1.68595692
38MP0002723_abnormal_immune_serum1.68013898
39MP0001790_abnormal_immune_system1.63280872
40MP0005387_immune_system_phenotype1.63280872
41MP0005023_abnormal_wound_healing1.62051702
42MP0010155_abnormal_intestine_physiology1.58378322
43MP0002933_joint_inflammation1.49828395
44MP0005076_abnormal_cell_differentiation1.45753668
45MP0003566_abnormal_cell_adhesion1.45138243
46MP0002277_abnormal_respiratory_mucosa1.43383578
47MP0002398_abnormal_bone_marrow1.42869010
48MP0000716_abnormal_immune_system1.41179070
49MP0009333_abnormal_splenocyte_physiolog1.36032666
50MP0003763_abnormal_thymus_physiology1.34892872
51MP0002396_abnormal_hematopoietic_system1.33492392
52MP0005671_abnormal_response_to1.32664681
53MP0002998_abnormal_bone_remodeling1.28590600
54MP0003656_abnormal_erythrocyte_physiolo1.28383714
55MP0003279_aneurysm1.28273026
56MP0003828_pulmonary_edema1.26356715
57MP0003191_abnormal_cellular_cholesterol1.26066501
58MP0000569_abnormal_digit_pigmentation1.23669685
59MP0005164_abnormal_response_to1.23204404
60MP0003448_altered_tumor_morphology1.22256213
61MP0002429_abnormal_blood_cell1.20462514
62MP0005390_skeleton_phenotype1.19168706
63MP0001663_abnormal_digestive_system1.18223228
64MP0004947_skin_inflammation1.18054112
65MP0005166_decreased_susceptibility_to1.16638042
66MP0008469_abnormal_protein_level1.14439392
67MP0001873_stomach_inflammation1.12673349
68MP0001958_emphysema1.12176729
69MP0000689_abnormal_spleen_morphology1.11560085
70MP0002722_abnormal_immune_system1.10529668
71MP0005319_abnormal_enzyme/_coenzyme1.10127549
72MP0005083_abnormal_biliary_tract1.03602836
73MP0001542_abnormal_bone_strength1.01350596
74MP0006054_spinal_hemorrhage0.99385600
75MP0001664_abnormal_digestion0.98986153
76MP0002139_abnormal_hepatobiliary_system0.98111506
77MP0000490_abnormal_crypts_of0.97982218
78MP0008004_abnormal_stomach_pH0.97641310
79MP0000477_abnormal_intestine_morphology0.97450682
80MP0005058_abnormal_lysosome_morphology0.96141839
81MP0003172_abnormal_lysosome_physiology0.92342866
82MP0003693_abnormal_embryo_hatching0.88968246
83MP0003453_abnormal_keratinocyte_physiol0.88577568
84MP0001765_abnormal_ion_homeostasis0.88572538
85MP0003866_abnormal_defecation0.86654849
86MP0002132_abnormal_respiratory_system0.86083946
87MP0005388_respiratory_system_phenotype0.85467893
88MP0002133_abnormal_respiratory_system0.85467893
89MP0005085_abnormal_gallbladder_physiolo0.84908630
90MP0002928_abnormal_bile_duct0.79823786
91MP0003806_abnormal_nucleotide_metabolis0.79499738
92MP0005381_digestive/alimentary_phenotyp0.78947814
93MP0003690_abnormal_glial_cell0.77917300
94MP0000920_abnormal_myelination0.77166812
95MP0000470_abnormal_stomach_morphology0.76922145
96MP0002166_altered_tumor_susceptibility0.75423999
97MP0001764_abnormal_homeostasis0.75368784
98MP0005174_abnormal_tail_pigmentation0.73327156
99MP0004510_myositis0.71510931
100MP0009763_increased_sensitivity_to0.71479899
101MP0005451_abnormal_body_composition0.68970083
102MP0010352_gastrointestinal_tract_polyps0.67895113
103MP0000678_abnormal_parathyroid_gland0.67655480
104MP0008260_abnormal_autophagy0.67139335
105MP0002282_abnormal_trachea_morphology0.66412669
106MP0001849_ear_inflammation0.66057198
107MP0000703_abnormal_thymus_morphology0.63581659
108MP0001986_abnormal_taste_sensitivity0.62577101
109MP0009765_abnormal_xenobiotic_induced0.61607376
110MP0000249_abnormal_blood_vessel0.61185374
111MP0003638_abnormal_response/metabolism_0.60427297
112MP0005310_abnormal_salivary_gland0.59682232
113MP0001216_abnormal_epidermal_layer0.58474038
114MP0010234_abnormal_vibrissa_follicle0.57483696
115MP0003795_abnormal_bone_structure0.56858670
116MP0000604_amyloidosis0.56788723
117MP0000747_muscle_weakness0.56669397
118MP0002089_abnormal_postnatal_growth/wei0.56081246
119MP0003123_paternal_imprinting0.55823769
120MP0008874_decreased_physiological_sensi0.54342178
121MP0009931_abnormal_skin_appearance0.53440183
122MP0004858_abnormal_nervous_system0.53330996
123MP0005365_abnormal_bile_salt0.52916115
124MP0005584_abnormal_enzyme/coenzyme_acti0.51938483
125MP0003045_fibrosis0.51148443
126MP0004381_abnormal_hair_follicle0.50808062

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)8.97834922
2Chronic obstructive pulmonary disease (HP:0006510)6.85181894
3Obstructive lung disease (HP:0006536)6.85181894
4Abnormality of macrophages (HP:0004311)6.50706879
5Gingivitis (HP:0000230)6.42184110
6Mediastinal lymphadenopathy (HP:0100721)6.20254351
7Recurrent skin infections (HP:0001581)5.09787643
8Cellulitis (HP:0100658)4.94496746
9Recurrent fungal infections (HP:0002841)4.91024953
10Urticaria (HP:0001025)4.90196446
11Stomatitis (HP:0010280)4.88034476
12Premature loss of primary teeth (HP:0006323)4.05945344
13Meningitis (HP:0001287)3.81256299
14Hyperactive renin-angiotensin system (HP:0000841)3.81144084
15Abnormal vertebral ossification (HP:0100569)3.56487453
16Episodic fever (HP:0001954)3.55207751
17Difficulty running (HP:0009046)3.54124740
18Myositis (HP:0100614)3.44670306
19Papilledema (HP:0001085)3.44101546
20Muscle fiber splitting (HP:0003555)3.28409807
21Osteomalacia (HP:0002749)3.22143477
22Increased connective tissue (HP:0009025)3.21348544
23Spontaneous hematomas (HP:0007420)3.18017987
24Abnormal platelet volume (HP:0011876)3.07772842
25Anorexia (HP:0002039)3.02749397
26Periodontitis (HP:0000704)2.91855358
27Recurrent pneumonia (HP:0006532)2.89226264
28Sepsis (HP:0100806)2.84797353
29Metabolic alkalosis (HP:0200114)2.77566779
30Osteomyelitis (HP:0002754)2.76134277
31Malnutrition (HP:0004395)2.70327832
32Abnormality of the costochondral junction (HP:0000919)2.70070202
33Vertebral clefting (HP:0008428)2.68570510
34Pustule (HP:0200039)2.66322936
35Colitis (HP:0002583)2.62947416
36Flat acetabular roof (HP:0003180)2.62023253
37Recurrent cutaneous fungal infections (HP:0011370)2.61690411
38Chronic mucocutaneous candidiasis (HP:0002728)2.61690411
39Increased mean platelet volume (HP:0011877)2.59499764
40Pathologic fracture (HP:0002756)2.58500555
41Hepatosplenomegaly (HP:0001433)2.52697296
42Orchitis (HP:0100796)2.51801995
43Skin ulcer (HP:0200042)2.50353577
44Widely patent fontanelles and sutures (HP:0004492)2.49031433
45Muscle fibrillation (HP:0010546)2.41378684
46Abnormality of renin-angiotensin system (HP:0000847)2.39390593
47Decreased circulating renin level (HP:0003351)2.36244530
48Increased IgM level (HP:0003496)2.36006909
49Panhypogammaglobulinemia (HP:0003139)2.35679529
50Pulmonary infiltrates (HP:0002113)2.33203321
51Abnormal foot bone ossification (HP:0010675)2.31164950
52IgM deficiency (HP:0002850)2.30811823
53Interstitial pulmonary disease (HP:0006530)2.30572193
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30260919
55Recurrent viral infections (HP:0004429)2.29313398
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.28620885
57Recurrent lower respiratory tract infections (HP:0002783)2.28591339
58Keratoconjunctivitis sicca (HP:0001097)2.26254293
59Increased serum ferritin (HP:0003281)2.25444811
60Slender build (HP:0001533)2.24316624
61Hyporeflexia of lower limbs (HP:0002600)2.18814697
62Hypermelanotic macule (HP:0001034)2.17310997
63Petechiae (HP:0000967)2.15661687
64Leukocytosis (HP:0001974)2.14625700
65Hemorrhage of the eye (HP:0011885)2.14277277
66Short femoral neck (HP:0100864)2.13254534
67Purpura (HP:0000979)2.12669280
68Vacuolated lymphocytes (HP:0001922)2.12441228
69Hypergammaglobulinemia (HP:0010702)2.12326409
70Thickened calvaria (HP:0002684)2.12143374
71Short 4th metacarpal (HP:0010044)2.10880468
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10880468
73Increased variability in muscle fiber diameter (HP:0003557)2.10721503
74Cheilitis (HP:0100825)2.09385576
75Increased IgE level (HP:0003212)2.08577108
76Amyloidosis (HP:0011034)2.08402252
77Chromsome breakage (HP:0040012)2.07761965
78Granulocytopenia (HP:0001913)2.07719565
79Gingival bleeding (HP:0000225)2.07245852
80Hypochromic anemia (HP:0001931)2.05672637
81Epistaxis (HP:0000421)2.04094485
82Keratoconjunctivitis (HP:0001096)2.02776120
83Metaphyseal irregularity (HP:0003025)2.00165382
84Eczematoid dermatitis (HP:0000976)10.9381861
85Recurrent abscess formation (HP:0002722)10.3904568
86Recurrent gram-negative bacterial infections (HP:0005420)10.0367820
87Systemic lupus erythematosus (HP:0002725)1.98354270
88Prolonged bleeding time (HP:0003010)1.98227947
89Cutaneous photosensitivity (HP:0000992)1.97864086
90Abnormality of skeletal muscle fiber size (HP:0012084)1.97050047
91Abnormality of chloride homeostasis (HP:0011422)1.96331699
92Gastrointestinal stroma tumor (HP:0100723)1.95976167
93Vasculitis (HP:0002633)1.95904044
94Hemoptysis (HP:0002105)1.95452955
95Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.93054860
96Agammaglobulinemia (HP:0004432)1.90757946
97Hypertriglyceridemia (HP:0002155)1.90586566
98Pyloric stenosis (HP:0002021)1.90111818
99Difficulty climbing stairs (HP:0003551)1.89802456
100Chest pain (HP:0100749)1.87667973
101Elevated erythrocyte sedimentation rate (HP:0003565)1.85438841
102Abnormality of alkaline phosphatase activity (HP:0004379)1.85216444
103Abnormal enzyme/coenzyme activity (HP:0012379)1.83997490
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81898086
105Autoimmune thrombocytopenia (HP:0001973)1.81855712
106Aplasia/hypoplasia of the femur (HP:0005613)1.80269324
107Inflammation of the large intestine (HP:0002037)1.79946059
108Abnormality of glycolipid metabolism (HP:0010969)1.79908844
109Abnormality of liposaccharide metabolism (HP:0010968)1.79908844
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.79908844
111Abnormality of iron homeostasis (HP:0011031)1.77222376
112Peritonitis (HP:0002586)1.76478021
113Absent frontal sinuses (HP:0002688)1.73304854
114Encephalitis (HP:0002383)1.73138323
115Retrobulbar optic neuritis (HP:0100654)1.70111889
116Optic neuritis (HP:0100653)1.70111889
117Gastrointestinal inflammation (HP:0004386)1.68961854
118Pulmonary embolism (HP:0002204)1.68689415
119Mesomelia (HP:0003027)1.65713530
120Thyroiditis (HP:0100646)1.65603200
121Duplicated collecting system (HP:0000081)1.63992460
122Papilloma (HP:0012740)1.63134901
123Verrucae (HP:0200043)1.63134901
124Recurrent sinusitis (HP:0011108)1.61835358
125Nonimmune hydrops fetalis (HP:0001790)1.60298910
126Abnormality of pyrimidine metabolism (HP:0004353)1.60146375
127Increased cerebral lipofuscin (HP:0011813)1.60126576
128Ectopic kidney (HP:0000086)1.59131271
129Metaphyseal cupping (HP:0003021)1.59120243
130Myelodysplasia (HP:0002863)1.58068582
131Tracheoesophageal fistula (HP:0002575)1.58067983
132Abnormality of cells of the lymphoid lineage (HP:0012140)1.58037542
133Lymphopenia (HP:0001888)1.57753802
134Abnormality of the common coagulation pathway (HP:0010990)1.57737339
135Eosinophilia (HP:0001880)1.57670647
136Chronic otitis media (HP:0000389)1.53583362
137Increased density of long bones (HP:0006392)1.52270881
138Long clavicles (HP:0000890)1.51359872
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.48073019
140Abnormality of T cell physiology (HP:0011840)1.47927211
141Persistence of primary teeth (HP:0006335)1.46364305
142Gastrointestinal infarctions (HP:0005244)1.44782566
143Abnormality of the pleura (HP:0002103)1.44257755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK45.76859732
2EPHB13.67133685
3RIPK43.23639168
4FGR3.07363783
5TRPM73.07098018
6BLK3.06922427
7CSK2.98904691
8TESK22.72111869
9CLK12.65199073
10GRK62.63526877
11FES2.60805041
12ERBB32.45269235
13ERN12.40089189
14MAP3K92.40066979
15MAP3K122.28473155
16BTK2.21419387
17STK102.19104967
18MAP2K32.11734578
19TESK12.10987348
20TTN2.04322582
21MAP4K11.85467588
22HCK1.79300519
23PRPF4B1.69186610
24PIK3CA1.65210854
25TRIB31.61729127
26TEC1.56743224
27PRKG21.52989072
28JAK31.49288676
29LRRK21.46124026
30KSR21.37867113
31PAK41.34561827
32PTK61.31643485
33SIK31.31586093
34MAP2K41.23967995
35ALK1.21662917
36PRKD21.20295371
37BRSK21.18491812
38TAOK11.16577037
39KDR1.16195689
40PTK21.14355123
41LIMK11.11210161
42MAP3K31.09701923
43ZAP701.04843859
44TAOK21.01256876
45MAP3K111.00598332
46MARK20.97811217
47MAP3K50.94561928
48MAPK40.93496765
49CDC42BPA0.93005930
50IKBKE0.91212930
51SMG10.90521989
52CSF1R0.89783063
53MAP2K60.86193634
54ITK0.86084359
55NEK20.85624718
56ACVR1B0.83339986
57TYK20.80893469
58SYK0.80454361
59PKN20.77095404
60LMTK20.76763758
61RET0.76002761
62WEE10.71184544
63MAP3K80.69670780
64JAK10.68865678
65TXK0.66890393
66PTK2B0.65789895
67MAP3K130.65522084
68STK40.64809356
69LYN0.64355219
70SIK10.61322628
71FYN0.59715491
72MAP3K70.59429701
73PIM10.59212870
74CDC70.58233810
75STK110.57555658
76RIPK10.57392688
77EPHA20.56682273
78MAP3K140.56512456
79MAP3K10.56148959
80FRK0.56020888
81BMX0.55587023
82PRKCD0.55412867
83CDK190.55064580
84RPS6KL10.53667596
85RPS6KC10.53667596
86PRKCH0.53524266
87MAPKAPK20.52836420
88JAK20.52163100
89TNK20.52035914
90NEK90.50275330
91GRK10.50128079
92RPS6KA60.50019192
93LCK0.49365781
94DMPK0.49310690
95MST1R0.48255559
96MATK0.47206049
97MAPK120.46293781
98PDPK10.45902513
99IKBKB0.45343291
100MARK30.44628533
101FGFR30.44353809
102ADRBK10.44134919
103EPHA30.42869672
104RPS6KA20.42212298
105PDK10.41710119
106CCNB10.40826098
107SGK30.40036281
108BMPR20.37760354
109DAPK20.35314311
110PRKCZ0.34236387
111MAP2K20.34119845
112PRKAA20.33308095
113FGFR40.33064220
114DYRK1B0.32238293
115IRAK10.32232120
116TGFBR20.31466121
117EGFR0.31406241
118MYLK0.30369627
119MAPK70.29792409
120MAP3K60.29409629
121ABL10.28764687
122TBK10.28552133
123PRKD10.28157257
124RPS6KA10.27546403
125MAPK110.26578767
126BRSK10.25973158
127PIK3CG0.25970742
128NEK10.25652350
129STK380.25587640
130YES10.24843159
131KIT0.23270871
132TAOK30.22659445
133IRAK30.22089835
134FGFR10.21015190
135SIK20.20534463
136MAP3K20.19980066
137PRKACB0.19266731

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051404.30883652
2Staphylococcus aureus infection_Homo sapiens_hsa051503.57816369
3Leukocyte transendothelial migration_Homo sapiens_hsa046703.38833647
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.83673366
5Asthma_Homo sapiens_hsa053102.73088249
6Osteoclast differentiation_Homo sapiens_hsa043802.55602790
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49460700
8Nitrogen metabolism_Homo sapiens_hsa009102.13728993
9Chemokine signaling pathway_Homo sapiens_hsa040622.06669585
10Shigellosis_Homo sapiens_hsa051312.01588732
11Tuberculosis_Homo sapiens_hsa051522.00765557
12Caffeine metabolism_Homo sapiens_hsa002321.97475386
13Pertussis_Homo sapiens_hsa051331.88169774
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.87273006
15B cell receptor signaling pathway_Homo sapiens_hsa046621.72606271
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72221598
17Platelet activation_Homo sapiens_hsa046111.66725439
18Pentose phosphate pathway_Homo sapiens_hsa000301.65552378
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53239271
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52352071
21Phagosome_Homo sapiens_hsa041451.51087598
22Galactose metabolism_Homo sapiens_hsa000521.50216718
23VEGF signaling pathway_Homo sapiens_hsa043701.48315473
24Hematopoietic cell lineage_Homo sapiens_hsa046401.47419989
25Salmonella infection_Homo sapiens_hsa051321.47158816
26Graft-versus-host disease_Homo sapiens_hsa053321.46633360
27Histidine metabolism_Homo sapiens_hsa003401.43020937
28Allograft rejection_Homo sapiens_hsa053301.42469804
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36325192
30Pancreatic cancer_Homo sapiens_hsa052121.35618785
31Primary immunodeficiency_Homo sapiens_hsa053401.33608197
32Autoimmune thyroid disease_Homo sapiens_hsa053201.33265153
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.32499377
34Bladder cancer_Homo sapiens_hsa052191.28308223
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28279500
36Toxoplasmosis_Homo sapiens_hsa051451.26756079
37Fructose and mannose metabolism_Homo sapiens_hsa000511.25502284
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25046883
39Sulfur metabolism_Homo sapiens_hsa009201.22045732
40Legionellosis_Homo sapiens_hsa051341.20902799
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17413013
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16479487
43TNF signaling pathway_Homo sapiens_hsa046681.13234877
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.12861485
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.07646777
46Acute myeloid leukemia_Homo sapiens_hsa052211.06988916
47Amoebiasis_Homo sapiens_hsa051461.06630730
48Hepatitis B_Homo sapiens_hsa051611.03412381
49Insulin resistance_Homo sapiens_hsa049310.98519095
50Type I diabetes mellitus_Homo sapiens_hsa049400.97744427
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.96258977
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95651737
53Viral myocarditis_Homo sapiens_hsa054160.94694632
54Other glycan degradation_Homo sapiens_hsa005110.93911904
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93077552
56Antigen processing and presentation_Homo sapiens_hsa046120.91597090
57Starch and sucrose metabolism_Homo sapiens_hsa005000.89513095
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88036753
59Non-small cell lung cancer_Homo sapiens_hsa052230.86248382
60Folate biosynthesis_Homo sapiens_hsa007900.85973816
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83121124
62Malaria_Homo sapiens_hsa051440.82892082
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.82235479
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81867571
65Chronic myeloid leukemia_Homo sapiens_hsa052200.81049011
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79998305
67Rap1 signaling pathway_Homo sapiens_hsa040150.79768398
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78054317
69Estrogen signaling pathway_Homo sapiens_hsa049150.76408128
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73489521
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73305437
72Endocytosis_Homo sapiens_hsa041440.71197791
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70430043
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69228462
75Influenza A_Homo sapiens_hsa051640.68509389
76Apoptosis_Homo sapiens_hsa042100.68266560
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67781818
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67296713
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.65744571
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65547664
81Dorso-ventral axis formation_Homo sapiens_hsa043200.63260233
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62431170
83Adherens junction_Homo sapiens_hsa045200.60627013
84Hepatitis C_Homo sapiens_hsa051600.60299928
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60101891
86Proteoglycans in cancer_Homo sapiens_hsa052050.59613985
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.58488147
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58155781
89Measles_Homo sapiens_hsa051620.57161529
90T cell receptor signaling pathway_Homo sapiens_hsa046600.53914257
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53364021
92Prolactin signaling pathway_Homo sapiens_hsa049170.52705766
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52396001
94ABC transporters_Homo sapiens_hsa020100.52077286
95Insulin signaling pathway_Homo sapiens_hsa049100.51760559
96Complement and coagulation cascades_Homo sapiens_hsa046100.51198549
97Herpes simplex infection_Homo sapiens_hsa051680.51126326
98Focal adhesion_Homo sapiens_hsa045100.50002470
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.49396060
100Collecting duct acid secretion_Homo sapiens_hsa049660.49039168
101Renal cell carcinoma_Homo sapiens_hsa052110.49023968
102Rheumatoid arthritis_Homo sapiens_hsa053230.48854676
103Inositol phosphate metabolism_Homo sapiens_hsa005620.48001339
104GnRH signaling pathway_Homo sapiens_hsa049120.47947739
105Glutathione metabolism_Homo sapiens_hsa004800.47659462
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.47389215
107FoxO signaling pathway_Homo sapiens_hsa040680.47250830
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45769845
109Glioma_Homo sapiens_hsa052140.45729444
110Pancreatic secretion_Homo sapiens_hsa049720.45405966
111Colorectal cancer_Homo sapiens_hsa052100.45348381
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.43331642
113African trypanosomiasis_Homo sapiens_hsa051430.42985749
114MAPK signaling pathway_Homo sapiens_hsa040100.42334352
115MicroRNAs in cancer_Homo sapiens_hsa052060.42219358
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42198264
117Lysosome_Homo sapiens_hsa041420.42187253
118Mineral absorption_Homo sapiens_hsa049780.39059016
119Choline metabolism in cancer_Homo sapiens_hsa052310.38563457
120Type II diabetes mellitus_Homo sapiens_hsa049300.38515407
121Notch signaling pathway_Homo sapiens_hsa043300.38454473
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37701770
123mTOR signaling pathway_Homo sapiens_hsa041500.37327590
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.35692229
125Salivary secretion_Homo sapiens_hsa049700.34578570
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34370642
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.33592103
128HIF-1 signaling pathway_Homo sapiens_hsa040660.32015156
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31699864
130Pathways in cancer_Homo sapiens_hsa052000.31279453
131Glycerolipid metabolism_Homo sapiens_hsa005610.29931711

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