CD180

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)7.72116265
2modulation by symbiont of host defense response (GO:0052031)7.72116265
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.72116265
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.72116265
5positive regulation by organism of defense response of other organism involved in symbiotic interact7.72116265
6modulation by symbiont of host immune response (GO:0052553)7.72116265
7regulation of interferon-beta biosynthetic process (GO:0045357)7.55945337
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.93326049
9macrophage activation involved in immune response (GO:0002281)5.73087758
10regulation of B cell receptor signaling pathway (GO:0050855)5.67698730
11positive regulation of interferon-alpha production (GO:0032727)5.60090438
12regulation of interferon-alpha production (GO:0032647)5.32981342
13microglial cell activation (GO:0001774)5.25956745
14response to host immune response (GO:0052572)5.01870649
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.01870649
16positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.78613811
17B cell receptor signaling pathway (GO:0050853)4.65439235
18response to host (GO:0075136)4.61498329
19response to host defenses (GO:0052200)4.61498329
20response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.61498329
21positive regulation of gamma-delta T cell activation (GO:0046645)4.53204600
22neutrophil activation involved in immune response (GO:0002283)4.47448787
23positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.44169995
24immunoglobulin mediated immune response (GO:0016064)4.37493175
25detection of other organism (GO:0098543)4.33759197
26I-kappaB phosphorylation (GO:0007252)4.30948970
27detection of bacterium (GO:0016045)4.16060026
28positive regulation of B cell differentiation (GO:0045579)4.07148467
29macrophage activation (GO:0042116)4.04647010
30antigen processing and presentation of endogenous antigen (GO:0019883)3.98723700
31positive regulation of antigen processing and presentation (GO:0002579)3.96830844
32positive regulation of interferon-beta production (GO:0032728)3.96605479
33response to peptidoglycan (GO:0032494)3.90988613
34respiratory burst (GO:0045730)3.87448359
35myeloid cell activation involved in immune response (GO:0002275)3.84816689
36germinal center formation (GO:0002467)3.79924272
37negative regulation of cell killing (GO:0031342)3.78700698
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78700698
39regulation of B cell differentiation (GO:0045577)3.76632838
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.76031015
41detection of external biotic stimulus (GO:0098581)3.75850301
42regulation of interferon-gamma biosynthetic process (GO:0045072)3.75164975
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58436169
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58436169
45pinocytosis (GO:0006907)3.56700519
46positive thymic T cell selection (GO:0045059)3.56258366
47detection of molecule of bacterial origin (GO:0032490)3.54853878
48neutrophil activation (GO:0042119)3.52974529
49B cell homeostasis (GO:0001782)3.50849563
50granulocyte activation (GO:0036230)3.49928318
51cytidine metabolic process (GO:0046087)3.44135727
52cytidine catabolic process (GO:0006216)3.44135727
53cytidine deamination (GO:0009972)3.44135727
54mature B cell differentiation (GO:0002335)3.41885607
55natural killer cell mediated cytotoxicity (GO:0042267)3.41355691
56natural killer cell mediated immunity (GO:0002228)3.41355691
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.41064029
58positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.33753259
59negative regulation of lymphocyte mediated immunity (GO:0002707)3.30270354
60positive regulation of toll-like receptor signaling pathway (GO:0034123)3.28234705
61regulation of antigen processing and presentation (GO:0002577)3.28099412
62negative regulation of B cell proliferation (GO:0030889)3.27265998
63detection of biotic stimulus (GO:0009595)3.26969878
64cellular extravasation (GO:0045123)3.24258953
65T-helper 1 type immune response (GO:0042088)3.23246927
66response to muramyl dipeptide (GO:0032495)3.22049950
67regulation of mast cell degranulation (GO:0043304)3.21576617
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21346414
69neutrophil mediated immunity (GO:0002446)3.19713606
70production of molecular mediator involved in inflammatory response (GO:0002532)3.18508641
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16857041
72positive regulation of leukocyte degranulation (GO:0043302)3.16246159
73defense response to protozoan (GO:0042832)3.16160172
74regulation of mast cell activation (GO:0033003)3.13604685
75B cell mediated immunity (GO:0019724)3.12592044
76response to protozoan (GO:0001562)3.10623507
77negative thymic T cell selection (GO:0045060)3.09262345
78negative regulation of granulocyte differentiation (GO:0030853)3.09233227
79leukocyte aggregation (GO:0070486)3.07827523
80regulation of interleukin-8 biosynthetic process (GO:0045414)3.07662205
81regulation of mast cell activation involved in immune response (GO:0033006)3.07023139
82negative regulation of leukocyte mediated immunity (GO:0002704)3.06642283
83NIK/NF-kappaB signaling (GO:0038061)3.06347826
84negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.06093436
85regulation of interferon-beta production (GO:0032648)3.05382804
86interferon-gamma-mediated signaling pathway (GO:0060333)3.04969498
87response to type I interferon (GO:0034340)3.03946449
88negative regulation of T cell mediated immunity (GO:0002710)3.03927538
89lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03118250
90negative regulation of mast cell activation (GO:0033004)3.02981274
91regulation of interleukin-12 biosynthetic process (GO:0045075)3.02781094
92type I interferon signaling pathway (GO:0060337)3.01812001
93cellular response to type I interferon (GO:0071357)3.01812001
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00216710
95cellular response to interferon-gamma (GO:0071346)2.99309622
96T cell migration (GO:0072678)2.96962780
97positive regulation of type 2 immune response (GO:0002830)2.96698504
98positive regulation of mast cell activation (GO:0033005)2.96019330
99N-acetylneuraminate metabolic process (GO:0006054)2.95743452
100myeloid leukocyte activation (GO:0002274)2.95521620
101regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93862553
102regulation of gamma-delta T cell activation (GO:0046643)2.93091102
103positive T cell selection (GO:0043368)2.92581408
104negative T cell selection (GO:0043383)2.92288854
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89756691
106negative regulation of interleukin-6 production (GO:0032715)2.89587542
107T cell selection (GO:0045058)2.88813215
108regulation of T-helper 2 cell differentiation (GO:0045628)2.87854943
109histamine secretion (GO:0001821)2.86545068
110regulation of gamma-delta T cell differentiation (GO:0045586)2.84406636
111negative regulation of interleukin-17 production (GO:0032700)2.84278250
112regulation of mononuclear cell migration (GO:0071675)2.83282978
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83185402
114regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.82961614
115negative regulation of interleukin-12 production (GO:0032695)2.82721899
116regulation of B cell proliferation (GO:0030888)2.82458716
117antigen receptor-mediated signaling pathway (GO:0050851)2.81598573
118negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81141579
119regulation of T cell tolerance induction (GO:0002664)2.79276346
120interferon-gamma production (GO:0032609)2.78085514
121positive regulation of interleukin-12 production (GO:0032735)2.77943502
122tolerance induction (GO:0002507)2.76923949
123cellular response to exogenous dsRNA (GO:0071360)2.73830816
124* B cell proliferation (GO:0042100)2.73707930
125cellular response to interferon-beta (GO:0035458)2.72926482
126regulation of germinal center formation (GO:0002634)2.72775455
127myeloid dendritic cell activation (GO:0001773)2.72209315
128regulation of leukocyte degranulation (GO:0043300)2.71470164
129adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.70548203
130positive regulation of cellular amide metabolic process (GO:0034250)2.69064997
131cellular response to zinc ion (GO:0071294)2.67743112
132positive regulation of chemokine production (GO:0032722)2.67637992
133positive regulation of mast cell activation involved in immune response (GO:0033008)2.67274606
134positive regulation of mast cell degranulation (GO:0043306)2.67274606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.69601796
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.54671093
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.84041677
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.38962880
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.33586257
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.93826959
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87784909
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.79040948
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64907799
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.33745866
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28926797
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.25936024
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.08519894
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05979954
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89641860
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72848579
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66788416
18SCL_19346495_ChIP-Seq_HPC-7_Human2.63330289
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.41692847
20VDR_21846776_ChIP-Seq_THP-1_Human2.40894682
21SPI1_23547873_ChIP-Seq_NB4_Human2.39243877
22SPI1_23127762_ChIP-Seq_K562_Human2.38409434
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27338570
24MYC_22102868_ChIP-Seq_BL_Human2.27122187
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.24048270
26RUNX_20019798_ChIP-Seq_JUKART_Human2.20772463
27VDR_24763502_ChIP-Seq_THP-1_Human2.15798257
28GATA1_22025678_ChIP-Seq_K562_Human2.14025689
29E2F7_22180533_ChIP-Seq_HELA_Human2.12470750
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05655277
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05038923
32* MYB_26560356_Chip-Seq_TH2_Human1.99961813
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98954256
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97954613
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.96128923
36PU_27001747_Chip-Seq_BMDM_Mouse1.94674762
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93595425
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93576251
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.91780850
40MYB_26560356_Chip-Seq_TH1_Human1.85472151
41* MAF_26560356_Chip-Seq_TH1_Human1.85006264
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72428496
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72194392
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.69698819
45VDR_24787735_ChIP-Seq_THP-1_Human1.65225659
46TCF7_22412390_ChIP-Seq_EML_Mouse1.62135451
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55882103
48UTX_26944678_Chip-Seq_JUKART_Human1.54467042
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51209822
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49005895
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46342424
52* GATA3_27048872_Chip-Seq_THYMUS_Human1.35968435
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34628992
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34326029
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34074958
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31441127
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29262982
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.28746502
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28398809
60* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26553978
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22834714
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20701122
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18274263
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.16681246
65GATA3_26560356_Chip-Seq_TH2_Human1.15891738
66* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15192837
67KDM2B_26808549_Chip-Seq_DND41_Human1.14808970
68TFEB_21752829_ChIP-Seq_HELA_Human1.13796317
69* GATA1_19941827_ChIP-Seq_MEL_Mouse1.12762765
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11736422
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08342804
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06331336
73BCL6_27268052_Chip-Seq_Bcells_Human1.06301258
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06105538
75* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05285449
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04367704
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04150464
78MAF_26560356_Chip-Seq_TH2_Human1.03336346
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.02801759
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95533046
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95373383
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94450100
83* BCOR_27268052_Chip-Seq_Bcells_Human0.92614427
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92274000
85STAT1_20625510_ChIP-Seq_HELA_Human0.88716491
86* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86485741
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83569636
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82817558
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81922375
90P300_27268052_Chip-Seq_Bcells_Human0.81436154
91* GATA3_26560356_Chip-Seq_TH1_Human0.79788875
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77651699
93* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76745427
94* GATA2_19941826_ChIP-Seq_K562_Human0.76633527
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75366987
96GATA1_19941826_ChIP-Seq_K562_Human0.74563731
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.74072402
98LXR_22292898_ChIP-Seq_THP-1_Human0.73731003
99* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73231647
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73000162
101* SMRT_27268052_Chip-Seq_Bcells_Human0.72715778
102RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72238868
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71348438
104SPI1_20517297_ChIP-Seq_HL60_Human0.71270126
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71007827
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.70998622
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.70401722
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.69643490
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66339743
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.63489468
111CIITA_25753668_ChIP-Seq_RAJI_Human0.61173017
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.60166052
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59542246
114NCOR1_26117541_ChIP-Seq_K562_Human0.58470771
115ERG_20887958_ChIP-Seq_HPC-7_Mouse0.58139463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.58182795
2MP0003303_peritoneal_inflammation3.85739554
3MP0005058_abnormal_lysosome_morphology3.58964330
4MP0000569_abnormal_digit_pigmentation3.25956021
5MP0001790_abnormal_immune_system3.23820678
6MP0005387_immune_system_phenotype3.23820678
7MP0006082_CNS_inflammation3.23026019
8MP0003172_abnormal_lysosome_physiology3.21491408
9* MP0001800_abnormal_humoral_immune3.21264583
10MP0003436_decreased_susceptibility_to3.07828162
11* MP0002452_abnormal_antigen_presenting3.00315950
12MP0002419_abnormal_innate_immunity2.93255268
13* MP0005000_abnormal_immune_tolerance2.91096221
14MP0005671_abnormal_response_to2.73357267
15* MP0002723_abnormal_immune_serum2.62363599
16MP0000685_abnormal_immune_system2.61815608
17MP0005464_abnormal_platelet_physiology2.47598280
18MP0005025_abnormal_response_to2.43836376
19* MP0002420_abnormal_adaptive_immunity2.40891519
20* MP0001819_abnormal_immune_cell2.40828751
21MP0002148_abnormal_hypersensitivity_rea2.40503146
22MP0004510_myositis2.24955629
23MP0003300_gastrointestinal_ulcer2.20668809
24MP0009785_altered_susceptibility_to2.19567323
25MP0003191_abnormal_cellular_cholesterol2.04813381
26MP0003183_abnormal_peptide_metabolism1.96321118
27* MP0002398_abnormal_bone_marrow1.93638026
28* MP0000716_abnormal_immune_system1.91698303
29MP0005257_abnormal_intraocular_pressure1.86891465
30* MP0000689_abnormal_spleen_morphology1.85968018
31MP0002138_abnormal_hepatobiliary_system1.85332915
32MP0001853_heart_inflammation1.85303911
33MP0002396_abnormal_hematopoietic_system1.84317637
34MP0002405_respiratory_system_inflammati1.79127329
35MP0004947_skin_inflammation1.74201910
36* MP0001845_abnormal_inflammatory_respons1.70174775
37MP0001533_abnormal_skeleton_physiology1.68564172
38MP0005174_abnormal_tail_pigmentation1.67036631
39MP0002166_altered_tumor_susceptibility1.60375005
40MP0003690_abnormal_glial_cell1.57615303
41* MP0002429_abnormal_blood_cell1.56502578
42MP0005310_abnormal_salivary_gland1.55963869
43* MP0002722_abnormal_immune_system1.54282963
44MP0009840_abnormal_foam_cell1.50566210
45MP0009278_abnormal_bone_marrow1.49611026
46MP0010307_abnormal_tumor_latency1.47275324
47MP0000604_amyloidosis1.43468463
48MP0008469_abnormal_protein_level1.42679581
49MP0003724_increased_susceptibility_to1.37293385
50MP0003448_altered_tumor_morphology1.34254640
51MP0000465_gastrointestinal_hemorrhage1.34131997
52MP0009333_abnormal_splenocyte_physiolog1.32233528
53MP0010155_abnormal_intestine_physiology1.30300882
54MP0000015_abnormal_ear_pigmentation1.29990346
55MP0001873_stomach_inflammation1.29003764
56MP0001851_eye_inflammation1.27918224
57MP0004808_abnormal_hematopoietic_stem1.25544909
58MP0005451_abnormal_body_composition1.21256284
59MP0002006_tumorigenesis1.20985089
60MP0003075_altered_response_to1.20446121
61MP0002998_abnormal_bone_remodeling1.19087175
62MP0001986_abnormal_taste_sensitivity1.15074327
63MP0000343_altered_response_to1.14958892
64MP0002933_joint_inflammation1.12786239
65MP0005397_hematopoietic_system_phenotyp1.12317056
66MP0001545_abnormal_hematopoietic_system1.12317056
67MP0003566_abnormal_cell_adhesion1.10317741
68MP0005166_decreased_susceptibility_to1.09533310
69MP0003828_pulmonary_edema1.05661969
70MP0009764_decreased_sensitivity_to1.01121576
71MP0004883_abnormal_blood_vessel1.00773445
72MP0003763_abnormal_thymus_physiology0.99390139
73MP0000703_abnormal_thymus_morphology0.98331521
74MP0000371_diluted_coat_color0.97588388
75MP0000858_altered_metastatic_potential0.90711909
76MP0002139_abnormal_hepatobiliary_system0.89178076
77MP0008004_abnormal_stomach_pH0.87008434
78MP0002132_abnormal_respiratory_system0.83877683
79MP0005076_abnormal_cell_differentiation0.83515388
80MP0003091_abnormal_cell_migration0.82358917
81MP0000490_abnormal_crypts_of0.78152736
82MP0003656_abnormal_erythrocyte_physiolo0.77303557
83MP0003045_fibrosis0.76390851
84MP0000767_abnormal_smooth_muscle0.76188679
85MP0002277_abnormal_respiratory_mucosa0.75274439
86MP0002928_abnormal_bile_duct0.72912306
87MP0010352_gastrointestinal_tract_polyps0.71997872
88MP0009763_increased_sensitivity_to0.71897315
89MP0005390_skeleton_phenotype0.71078065
90MP0004381_abnormal_hair_follicle0.71015362
91MP0001915_intracranial_hemorrhage0.70107872
92MP0005075_abnormal_melanosome_morpholog0.68879119
93MP0002693_abnormal_pancreas_physiology0.68501472
94* MP0002136_abnormal_kidney_physiology0.66788578
95MP0002090_abnormal_vision0.66173306
96* MP0000249_abnormal_blood_vessel0.66114769
97MP0003866_abnormal_defecation0.63621995
98MP0003806_abnormal_nucleotide_metabolis0.62924962
99MP0005197_abnormal_uvea_morphology0.61021802
100MP0003795_abnormal_bone_structure0.60107842
101MP0002254_reproductive_system_inflammat0.59771434
102MP0008874_decreased_physiological_sensi0.59571450
103MP0003646_muscle_fatigue0.57626523
104MP0002095_abnormal_skin_pigmentation0.56850366
105MP0005164_abnormal_response_to0.56584082
106MP0005167_abnormal_blood-brain_barrier0.56102879
107MP0003252_abnormal_bile_duct0.55619835
108MP0008260_abnormal_autophagy0.55214686
109MP0001958_emphysema0.54976982
110MP0005023_abnormal_wound_healing0.54938966
111MP0005584_abnormal_enzyme/coenzyme_acti0.54894672
112MP0009115_abnormal_fat_cell0.54513001
113MP0002019_abnormal_tumor_incidence0.54152062
114MP0002009_preneoplasia0.53374745
115MP0006054_spinal_hemorrhage0.53321074
116MP0000920_abnormal_myelination0.52708590
117MP0000609_abnormal_liver_physiology0.52142742
118MP0001663_abnormal_digestive_system0.51506335

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.19754199
2Recurrent bacterial skin infections (HP:0005406)5.68075985
3Increased cerebral lipofuscin (HP:0011813)5.40330641
4Eczematoid dermatitis (HP:0000976)4.81647588
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.80094832
6Systemic lupus erythematosus (HP:0002725)4.50627592
7Vacuolated lymphocytes (HP:0001922)4.41766663
8Abnormality of liposaccharide metabolism (HP:0010968)4.29110873
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.29110873
10Abnormality of glycolipid metabolism (HP:0010969)4.29110873
11Recurrent gram-negative bacterial infections (HP:0005420)4.23090157
12Abnormality of macrophages (HP:0004311)4.05567620
13Dysostosis multiplex (HP:0000943)3.91256925
14Disinhibition (HP:0000734)3.85189757
15Mediastinal lymphadenopathy (HP:0100721)3.72527135
16Recurrent skin infections (HP:0001581)3.72106515
17Gastrointestinal stroma tumor (HP:0100723)3.68618217
18Cellulitis (HP:0100658)3.64876058
19Recurrent viral infections (HP:0004429)3.62162154
20Recurrent fungal infections (HP:0002841)3.47640585
21Colitis (HP:0002583)3.46821217
22Autoimmune thrombocytopenia (HP:0001973)3.46178786
23Vasculitis (HP:0002633)3.37903981
24Agammaglobulinemia (HP:0004432)3.36766023
25Obstructive lung disease (HP:0006536)3.33942327
26Chronic obstructive pulmonary disease (HP:0006510)3.33942327
27Mucopolysacchariduria (HP:0008155)3.31492284
28Urinary glycosaminoglycan excretion (HP:0003541)3.31492284
29Abnormality of polysaccharide metabolism (HP:0011012)3.29686409
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29686409
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29686409
32Glomerulonephritis (HP:0000099)3.28005899
33Encephalitis (HP:0002383)3.19432121
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.13058904
35Inflammation of the large intestine (HP:0002037)3.05780526
36Agnosia (HP:0010524)3.04122517
37Myositis (HP:0100614)3.03480341
38Recurrent pneumonia (HP:0006532)3.00351017
39Axonal loss (HP:0003447)2.97314507
40IgM deficiency (HP:0002850)2.97211701
41Gingivitis (HP:0000230)2.94404127
42Chronic mucocutaneous candidiasis (HP:0002728)2.94255653
43Recurrent cutaneous fungal infections (HP:0011370)2.94255653
44Meningitis (HP:0001287)2.93393485
45Hemoptysis (HP:0002105)2.92656082
46Osteomyelitis (HP:0002754)2.90956095
47Loss of speech (HP:0002371)2.88654943
48Gastrointestinal infarctions (HP:0005244)2.87149551
49Gastrointestinal inflammation (HP:0004386)2.85621172
50Elevated erythrocyte sedimentation rate (HP:0003565)2.81765916
51Chronic otitis media (HP:0000389)2.78762252
52Emphysema (HP:0002097)2.77778734
53Myocardial infarction (HP:0001658)2.74794882
54Recurrent lower respiratory tract infections (HP:0002783)2.73913790
55T lymphocytopenia (HP:0005403)2.73025255
56Hematochezia (HP:0002573)2.71934284
57Periodontitis (HP:0000704)2.71370059
58Chest pain (HP:0100749)2.63683029
59Prostate neoplasm (HP:0100787)2.63681719
60Abnormality of T cell number (HP:0011839)2.61570958
61Lymphopenia (HP:0001888)2.59007463
62Petechiae (HP:0000967)2.58599598
63Basal ganglia calcification (HP:0002135)2.55981851
64Keratoconjunctivitis sicca (HP:0001097)2.55585522
65Prolonged bleeding time (HP:0003010)2.52553148
66Epistaxis (HP:0000421)2.50121763
67Recurrent bronchitis (HP:0002837)2.47661779
68Increased IgE level (HP:0003212)2.47634590
69Keratoconjunctivitis (HP:0001096)2.46500746
70Interstitial pulmonary disease (HP:0006530)2.45709961
71Restrictive lung disease (HP:0002091)2.45405003
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.44784144
73Orchitis (HP:0100796)2.43968177
74Pustule (HP:0200039)2.43448395
75Abnormality of T cells (HP:0002843)2.42109222
76Purpura (HP:0000979)2.41188245
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37776347
78Stomatitis (HP:0010280)2.37368166
79Recurrent sinusitis (HP:0011108)2.35660927
80Pulmonary embolism (HP:0002204)2.35200065
81Abnormality of the prostate (HP:0008775)2.32777151
82Pathologic fracture (HP:0002756)2.30641043
83IgA deficiency (HP:0002720)2.29096971
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.25856070
85Optic neuritis (HP:0100653)2.22606003
86Retrobulbar optic neuritis (HP:0100654)2.22606003
87Hepatosplenomegaly (HP:0001433)2.19478930
88Thoracic kyphosis (HP:0002942)2.17744338
89Abnormality of the pleura (HP:0002103)2.17266978
90Thyroiditis (HP:0100646)2.16568224
91Pulmonary infiltrates (HP:0002113)2.15640208
92Spontaneous hematomas (HP:0007420)2.15548111
93Abnormality of T cell physiology (HP:0011840)2.14890953
94Upper motor neuron abnormality (HP:0002127)2.14796228
95Inappropriate behavior (HP:0000719)2.14550487
96Chronic diarrhea (HP:0002028)2.13562158
97Cerebral aneurysm (HP:0004944)2.12239058
98Leukopenia (HP:0001882)2.09706324
99Polyneuropathy (HP:0001271)2.09596963
100Gingival bleeding (HP:0000225)2.09553405
101Leukocytosis (HP:0001974)2.08675656
102Panhypogammaglobulinemia (HP:0003139)2.07438863
103Retinal atrophy (HP:0001105)2.05876564
104Verrucae (HP:0200043)2.04715438
105Papilloma (HP:0012740)2.04715438
106Abnormal platelet function (HP:0011869)2.04361230
107Impaired platelet aggregation (HP:0003540)2.04361230
108Neuronal loss in central nervous system (HP:0002529)2.03955488
109J-shaped sella turcica (HP:0002680)2.03183096
110Urethral obstruction (HP:0000796)1.98444243
111IgG deficiency (HP:0004315)1.98094668
112Eosinophilia (HP:0001880)1.97178552
113Increased IgM level (HP:0003496)1.96699314
114Anorexia (HP:0002039)1.96673973
115Nephritis (HP:0000123)1.96311998
116Sepsis (HP:0100806)1.96134237
117Amyloidosis (HP:0011034)1.96110064
118Viral hepatitis (HP:0006562)1.95949703
119Thick nail (HP:0001805)1.95841614
120Arterial thrombosis (HP:0004420)1.95426339
121Complement deficiency (HP:0004431)1.95221361
122Urticaria (HP:0001025)1.95132289
123Mutism (HP:0002300)1.94139299
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93217857
125Arthralgia (HP:0002829)1.91465800
126Skin rash (HP:0000988)1.90939421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.51094217
2RIPK43.40438962
3TGFBR23.32054531
4KIT3.24818364
5CSF1R2.90851341
6BLK2.90405908
7TYK22.88487626
8ERN12.85535071
9IRAK42.64340693
10IRAK32.59428297
11TBK12.59154039
12MAP3K142.40565994
13CAMK1D2.21245613
14SYK2.13898236
15JAK12.01126045
16SIK21.91959708
17MAP3K131.88575323
18CAMK1G1.85214539
19BTK1.79174048
20HCK1.78464893
21TAOK31.71667461
22STK101.71375697
23CDK121.68461202
24ZAP701.63089787
25FES1.62431517
26IKBKE1.61966107
27IKBKB1.59057689
28BMPR21.55638489
29JAK31.54977705
30LYN1.54137123
31ITK1.51149065
32CSK1.46863340
33PRPF4B1.41872367
34NEK91.31529553
35LCK1.28218066
36GRK71.23555868
37CLK11.23353828
38MARK31.20212284
39TEC1.19151955
40MATK1.16937604
41FRK1.16429095
42MAP3K111.14481116
43PIK3CG1.14458898
44MAP2K31.12159884
45TXK1.11385985
46ACVR1B1.10143235
47GRK61.08149352
48SIK31.05721865
49FGR1.04487078
50RPS6KA40.99255390
51TAOK10.97950786
52LRRK20.94780051
53CDK190.94269808
54EPHB10.91617635
55CDC42BPA0.90315427
56CHUK0.89854828
57FGFR30.86860219
58JAK20.82873953
59MAP3K10.81802601
60MAP3K100.81218559
61EGFR0.78728221
62IRAK10.75090548
63CDK60.74212560
64PIM10.73733350
65PKN20.69099002
66ABL10.65925050
67PRKCQ0.65216725
68SCYL20.62206924
69STK40.61159833
70MAPK120.60886273
71PTK60.59302405
72PDK10.58094930
73TTN0.57832575
74BRD40.57758814
75PRKCH0.54925935
76MAPK70.54122417
77MARK20.53496153
78STK30.51690121
79PRKCD0.50581557
80PTK2B0.50347906
81MAP3K90.48236008
82MAP2K60.48085853
83CAMKK20.46374451
84IRAK20.45859809
85FYN0.44758605
86PDPK10.41716705
87MAPKAPK20.41584780
88TAOK20.40932844
89TRIB30.40427814
90PAK40.40284604
91TESK20.38654030
92YES10.37704916
93ALK0.37343469
94NLK0.36624905
95FGFR40.36149673
96NME20.34759050
97SGK30.34206655
98INSRR0.34201124
99MAP2K20.33922467
100BMX0.33751846
101TRPM70.33643329
102CAMKK10.33376653
103PRKD20.33219963
104IGF1R0.32549165
105HIPK20.32238220
106STK110.32150627
107KSR20.31625542
108DAPK20.30515013
109MAPK40.30290124
110MOS0.29816455
111MAPK110.29429025
112CAMK40.29159306
113ATR0.29016353
114CDK40.28252446
115INSR0.28245391
116MAP3K80.28017470
117RPS6KL10.27034241
118RPS6KC10.27034241
119RPS6KA60.26687260
120ADRBK20.26386451
121MAP3K50.26194242
122CDK90.26135636
123OXSR10.25931399
124SIK10.24597186
125TNK20.23814454
126GRK10.23455292
127DMPK0.23024675
128SRC0.21508664
129MAP3K30.20935723

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.46480368
2B cell receptor signaling pathway_Homo sapiens_hsa046623.36413840
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.23784019
4Staphylococcus aureus infection_Homo sapiens_hsa051503.01930581
5Leishmaniasis_Homo sapiens_hsa051402.89957916
6Type I diabetes mellitus_Homo sapiens_hsa049402.88945636
7Osteoclast differentiation_Homo sapiens_hsa043802.82564534
8Lysosome_Homo sapiens_hsa041422.65919930
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.59500929
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.44597476
11Other glycan degradation_Homo sapiens_hsa005112.39849159
12Primary immunodeficiency_Homo sapiens_hsa053402.25050917
13Tuberculosis_Homo sapiens_hsa051522.18161001
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06584407
15Pertussis_Homo sapiens_hsa051331.96345315
16Hematopoietic cell lineage_Homo sapiens_hsa046401.93585916
17Antigen processing and presentation_Homo sapiens_hsa046121.91626439
18Measles_Homo sapiens_hsa051621.88567515
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.87361036
20Influenza A_Homo sapiens_hsa051641.67329360
21Malaria_Homo sapiens_hsa051441.65002499
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63909388
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61982651
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60068344
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57659713
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56412834
27Toxoplasmosis_Homo sapiens_hsa051451.50186916
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47635349
29Phagosome_Homo sapiens_hsa041451.44634307
30Legionellosis_Homo sapiens_hsa051341.44317307
31Herpes simplex infection_Homo sapiens_hsa051681.40184504
32Chemokine signaling pathway_Homo sapiens_hsa040621.39393237
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37695863
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35117397
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34968975
36Apoptosis_Homo sapiens_hsa042101.33306812
37Hepatitis B_Homo sapiens_hsa051611.31178116
38Rheumatoid arthritis_Homo sapiens_hsa053231.25337107
39Shigellosis_Homo sapiens_hsa051311.25075391
40TNF signaling pathway_Homo sapiens_hsa046681.20888072
41Salmonella infection_Homo sapiens_hsa051321.18897990
42Chronic myeloid leukemia_Homo sapiens_hsa052201.16609268
43Pancreatic cancer_Homo sapiens_hsa052121.14146526
44T cell receptor signaling pathway_Homo sapiens_hsa046601.11281637
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.07719087
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.06744312
47Hepatitis C_Homo sapiens_hsa051601.00062515
48Platelet activation_Homo sapiens_hsa046110.99022605
49African trypanosomiasis_Homo sapiens_hsa051430.95114678
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94990104
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94524753
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.93373720
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92758180
54Allograft rejection_Homo sapiens_hsa053300.90645448
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89606756
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88243416
57Acute myeloid leukemia_Homo sapiens_hsa052210.87478699
58Systemic lupus erythematosus_Homo sapiens_hsa053220.87263997
59Graft-versus-host disease_Homo sapiens_hsa053320.85527248
60Viral myocarditis_Homo sapiens_hsa054160.85338319
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85318564
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84652868
63Complement and coagulation cascades_Homo sapiens_hsa046100.83555906
64Asthma_Homo sapiens_hsa053100.82061092
65Caffeine metabolism_Homo sapiens_hsa002320.77959635
66Epstein-Barr virus infection_Homo sapiens_hsa051690.73677599
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.71690716
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70802237
69Notch signaling pathway_Homo sapiens_hsa043300.69619247
70Endocytosis_Homo sapiens_hsa041440.67030647
71Non-small cell lung cancer_Homo sapiens_hsa052230.64732494
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64094311
73Small cell lung cancer_Homo sapiens_hsa052220.58678649
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58361748
75Viral carcinogenesis_Homo sapiens_hsa052030.57807107
76Amoebiasis_Homo sapiens_hsa051460.56622107
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56552365
78Type II diabetes mellitus_Homo sapiens_hsa049300.56056928
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55234701
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54862932
81VEGF signaling pathway_Homo sapiens_hsa043700.54409340
82Sphingolipid metabolism_Homo sapiens_hsa006000.52376709
83Prolactin signaling pathway_Homo sapiens_hsa049170.52217843
84Inositol phosphate metabolism_Homo sapiens_hsa005620.51940012
85HIF-1 signaling pathway_Homo sapiens_hsa040660.51924530
86Renal cell carcinoma_Homo sapiens_hsa052110.49551687
87HTLV-I infection_Homo sapiens_hsa051660.48803583
88Colorectal cancer_Homo sapiens_hsa052100.48565767
89mTOR signaling pathway_Homo sapiens_hsa041500.42789211
90MicroRNAs in cancer_Homo sapiens_hsa052060.42017925
91Glioma_Homo sapiens_hsa052140.41149191
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40363616
93Proteoglycans in cancer_Homo sapiens_hsa052050.39488425
94Lysine degradation_Homo sapiens_hsa003100.36242886
95FoxO signaling pathway_Homo sapiens_hsa040680.35370590
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.34888610
97Dorso-ventral axis formation_Homo sapiens_hsa043200.34811856
98Renin-angiotensin system_Homo sapiens_hsa046140.33253675
99Insulin resistance_Homo sapiens_hsa049310.32964668
100MAPK signaling pathway_Homo sapiens_hsa040100.32375330
101ABC transporters_Homo sapiens_hsa020100.31547932
102Prostate cancer_Homo sapiens_hsa052150.29319296
103Prion diseases_Homo sapiens_hsa050200.26625107
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26065829
105Collecting duct acid secretion_Homo sapiens_hsa049660.25381899
106GnRH signaling pathway_Homo sapiens_hsa049120.23579843
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.22814416
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21834695
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21805207
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.20943448
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19547064
112Ether lipid metabolism_Homo sapiens_hsa005650.18991078
113Arachidonic acid metabolism_Homo sapiens_hsa005900.18369743
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18160473
115Regulation of autophagy_Homo sapiens_hsa041400.15915361
116Choline metabolism in cancer_Homo sapiens_hsa052310.15700889
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11200674

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